PMID
int64 35.7M
36.4M
| Title/Abstract
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101
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36,279,465
|
mammalian octopus cell direct select frequenc sweep excitatori synapt sequenc detect octopus cell remark project neuron mammalian cochlear nucleus extrem fast membran wide frequenc tune consid prime exampl coincid detector poor character vivo discov octopus cell select frequenc sweep direct featur absent auditori nerv input vivo intracellular record reveal direct select deriv across frequenc coincid detect hing amplitud activ sequenc auditori nerv input tune cluster hot spot frequenc simpl biophys octopus cell model excit real nerv spike train recreat direct select interact intrins membran conduct activ sequenc cluster excitatori input conclud octopus cell sequenc detector sensit tempor pattern across cochlear frequenc channel detect sequenc rather coincid much simpler power oper extract tempor inform
|
D049831;D017626
|
T023;T204
|
36,279,464
|
hoip modul stabil gpx linear ubiquitin lubac mediat linear ubiquitin play pivot role regul cell death inflammatori pathway genet defici lubac compon lead sever immun dysfunct embryon lethal lubac extens studi role mediat tnf signal howev tnfr knockout abl fulli rescu embryon lethal lubac defici suggest lubac may modifi addit key cellular substrat promot cell surviv gpx import selenoprotein involv regul cellular redox homeostasi defens lipid peroxid mediat cell death known ferroptosi demonstr lubac defici sensit ferroptosi promot gpx degrad downstream lipid peroxid lubac bind stabil gpx modul linear ubiquitin normal condit oxid stress find identifi gpx key substrat lubac previous unrecogn role lubac mediat linear ubiquitin regul cellular redox status cell death
|
D047888;D025801
|
T129;T123;T116;T192
|
36,279,463
|
estim total treatment effect random experi unknown network structur random experi wide use estim causal effect propos treatment mani area scienc medicin healthcar physic biolog scienc social scienc engin public polici technolog industri consid situat classic method estim total treatment effect target popul consider bias due confound network effect ie fact treatment individu may impact neighbor outcom issu refer network interfer nonindividu treatment respons key challeng situat network often unknown difficult cost measur assum potenti outcom model heterogen addit network effect encompass broad class network interfer sourc includ spillov peer effect contagion first character limit estim total treatment effect without knowledg network drive interfer contrast subsequ develop simpl estim effici random design output unbias estim low varianc situat one given access averag histor baselin measur prior experi solut requir knowledg under network structur come statist guarante broad class model due eas interpret implement theoret guarante believ result signific impact design random experi
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D016032
|
T062;T170
|
36,279,462
|
influenc molecular design structur properti relationship supramolecular polym prodrug supramolecular self assembl hydrophil macromolecul function hydrophob structur direct compon long use drug deliveri system load poor solubl compound typic achiev physic encapsul format supramolecular assembl result low encapsul effici limit control releas kinet predomin govern diffus carrier degrad overcom limit amphiphil prodrug leverag hydrophob drug therapeut structur direct compon use creat supramolecular materi higher load control releas kinet use biodegrad enzymat cleavabl linker report design synthesi character librari supramolecular polym prodrug base poli ethylen glycol peg proregen drug dihydrophenonthrolin one carboxyl acid dpca structur properti relationship elucid experiment character prodrug behavior wet dri state use scatter techniqu electron microscopi corrobor coars grain model molecular architectur hydrophob hydrophil ratio peg dpca conjug strong influenc physic state water rang fulli solubl supramolecular spheric assembl nanofib molecular design supramolecular structur turn shown dramat alter hydrolyt enzymat releas cellular transport dpca addit potenti expand therapeut option dpca control supramolecular assembl design principl elabor may inform develop supramolecular prodrug base hydrophob small molecul compound
|
D011355
|
T120
|
36,279,461
|
energi effici network activ dispar circuit paramet neural circuit produc similar activ pattern vast differ combin channel synapt conduct conduct tune specif activ pattern might also reflect addit constraint metabol cost robust perturb constraint influenc rang permiss conduct investig metabol cost affect paramet neural circuit similar activ model pylor network crab cancer boreali present machin learn method identifi rang network model generat activ pattern match experiment data find neural circuit consum larg differ amount energi despit similar circuit activ furthermor reduc still signific rang circuit paramet give rise energi effici circuit examin space paramet energi effici circuit identifi potenti tune strategi low metabol cost final investig interact metabol cost temperatur robust show metabol cost vari across temperatur robust temperatur chang necessarili incur increas metabol cost analys show despit metabol effici temperatur robust constrain circuit paramet neural system generat function effici robust network activ wide dispar set conduct
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D011708
|
T023
|
36,279,460
|
electrophysiolog marker memori consolid human brain memori reactiv sleep human accomplish depend learn effect learn depend consolid consolid process wherebi new memori gradual store endur way brain avail need factual event knowledg consolid thought progress sleep well wake state mediat interact hippocamp neocort network howev consolid difficult observ direct rather infer behavior observ investig overnight memori chang measur electr activ near hippocampus electroencephalograph eeg record made five patient electrod implant determin whether surgic treatment could reliev seizur disord one night patient slept hospit monitor room record electrophysiolog respons specif sound present quiet avoid arous half sound associ object precis spatial locat patient learn sleep sleep found systemat improv spatial recal replic prior result assum sound present sleep reactiv strengthen correspond spatial memori notabl sound also elicit oscillatori intracrani eeg activ includ increas theta sigma gamma eeg band gamma respons particular consist associ degre improv spatial memori exhibit sleep thus conclud electrophysiolog activ hippocampus adjac medial tempor cortex reflect sleep base enhanc memori storag
|
D000069077
|
T041
|
36,279,459
|
predict code multisensori integr attent control multicompon framework lucid dream lucid dream ld mental state realiz awak dream asleep often involv vivid perceptu intens dream imag well peculiar kinesthet sensat fli levit bodi experi ld cross spotlight cognit neurosci sleep research particular case studi conscious cognit neural background dream experi present multicompon framework studi understand neurocognit mechan phenomenolog aspect ld propos ld associ predict error signal aris sleep occur higher lower level process hierarchi predict error resolv generat superordin self model abl integr ambigu stimuli arriv sensori peripheri higher order cortic region multisensori integr enabl lucid mainten contribut peculiar kinesthet experi attent control facilit multisensori integr dynam regul balanc influenc top mental model precis weight bottom sensori input novel framework aim link neural correl ld current concept sleep arous regul provid testabl predict interindividu differ ld well neurocognit mechan induc lucid dream
|
D012895;D004325
|
T184;T041;T042
|
36,279,456
|
neuron signatur spatial decis make navig freeli move rat use calcium imag challeng spatial memori understand place cell fire contribut decis make navig spatial recenc task creat freeli move rat first becam familiar spatial context sever day thereaft requir encod select recal one three specif locat within chosen reward day calcium imag use record cell area ca hippocampus five rat explor sampl choic phase daili task key find neural activ startbox rose steadili short period prior entri arena select popul cell fire predict daili chang goal correct trial trial anim made error singl cell popul activ measur converg idea prospect code neural activ involv navig decis make
|
D000071037;D065854
|
T025;T041
|
36,279,454
|
predict network dynam without requir knowledg interact graph network consist two interdepend part network topolog graph consist link node network dynam specifi govern equat crucial challeng predict dynam network forecast spread infecti diseas human contact network unfortun accur predict dynam seem hard feasibl network often complic unknown work given past observ dynam fix graph show contrari even without know network topolog predict dynam specif general class determinist govern equat propos two step predict algorithm first obtain surrog network fit past observ everi nodal state dynam model second iter govern equat surrog network predict dynam surpris even though similar surrog topolog true topolog predict accur consider predict time horizon broad rang observ time presenc reason nois level true topolog need predict dynam network sinc dynam evolv subspac astonish low dimens compar size heterogen graph result constitut fresh perspect broad field nonlinear dynam complex network
|
D000465;D017711
|
T077;T170
|
36,279,453
|
reconstruct biblic militari campaign use geomagnet field data hebrew bibl ancient near eastern text describ egyptian aramean assyrian babylonian militari campaign southern levant th sixth centuri bce inde mani destruct layer date period unearth archaeolog excav sever layer secur link specif campaign wide accept chronolog anchor howev date mani destruct layer often debat challeng abil accur reconstruct differ militari campaign rais question regard histor biblic narrat present synchron histor date chronolog anchor destruct layer artifact use direct andor intens ancient geomagnet field record mud brick burnt destruct layer two ceram assemblag period question geomagnet field region extrem anomal rapid chang high intens valu includ spike twice intens today field data use effort pinpoint short term variat timescal resolv chronolog debat regard campaign kingdom israel judah relationship two kingdom administr
|
D001633;D008889
|
T170;T073;T097
|
36,279,452
|
bovin human endometrium deriv hydrogel support organoid cultur healthi cancer tissu organoid technolog provid uniqu insight human organ develop function diseas patient deriv organoid increas use drug screen model rare disord design regen therapi understand diseas pathogenesi howev use matrigel grow organoid repres major challeng clinic translat organoid technolog matrigel poor defin mixtur extracellular matrix protein growth factor extract engelbreth holm swarm mous tumor extracellular matrix major driver multipl cellular process differ signific tissu well healthi diseas state tissu therefor envis extracellular matrix deriv nativ healthi tissu would abl support organoid growth akin organogenesi vivo develop hydrogel decellular human bovin endometrium hydrogel support growth mous human endometri organoid compar matrigel organoid grown endometri hydrogel proteom similar nativ tissu cultur matrigel proteom raman microspectroscopi analys show method decellular affect biochem composit hydrogel subsequ abil support organoid growth amount laminin hydrogel correl number shape organoid also demonstr util endometri hydrogel develop solid scaffold support high throughput cell cultur base applic summari endometri hydrogel overcom major limit organoid technolog great expand applic organoid understand endometri biolog associ patholog
|
D009940;D009369
|
T191;T024
|
36,279,451
|
us embassi air qualiti tweet led global health benefit world health organ estim world popul expos hazard level local air pollut air pollut mark wors low middl incom countri yet air qualiti monitor typic spars us embassi beij began tweet hour air qualiti inform newli instal pollut monitor dramat improv inform air qualiti avail beij resid sinc unit state instal monitor around world tweet real time report air qualiti locat use spatial granular measur local air pollut satellit data span globe employ variat whether us embassi instal monitor evalu impact air qualiti inform pollut estim embassi monitor led reduct fine particul concentr level host countri gm central estim annual monet benefit decreas prematur mortal due reduct pollut million median citi find point substanti benefit improv avail salienc air qualiti inform low middl incom countri
|
D052638;D000397
|
T131;T069;T167;T080
|
36,279,450
|
input integr circadian clock exhibit nonaddit fold chang detect circadian clock synchron extern time cue align one anoth environ various signal pathway shown independ reset phase clock howev bodi circadian clock expos multitud potenti time cue complex tempor dynam rais question clock integr inform respons multipl signal investig differ mode signal integr circadian clock use circa scope method recent develop high throughput phase reset analysi found simultan exposur differ combin known pharmacolog reset agent elicit divers rang respons often respons nonaddit could readili predict respons individu signal instanc observ dexamethason domin test input case signal administ sequenti background level signal attenu subsequ reset signal signal act differ pathway led us examin whether circadian clock sensit relat rather absolut level signal import analysi reveal involv signal specif fold chang detect mechan clock respons mechan like stem properti signal pathway upstream clock overal find elucid mode input integr circadian clock potenti relev clock reset physiolog patholog condit
|
D057906
|
T040
|
36,279,449
|
shape overnight consolid via slow oscil close loop target memori reactiv sleep constitut privileg state new memori reactiv consolid previous work demonstr consolid bolster experiment either via deliveri remind cue target memori reactiv tmr via noninvas brain stimul gear toward enhanc endogen sleep rhythm combin approach control time tmr cue respect ongo slow oscil phase prior sleep particip learn associ uniqu word set repeat imag eg car hear prototyp imag sound eg engin start memori perform immedi test vs test next morn quantifi overnight memori consolid import two imag sound design tmr cue one cue deliv state deliv state novel sound use tmr control condit behavior result reveal signific reduct overnight forget word associ state tmr compar word associ state tmr electrophysiolog result show state cue led enhanc ongo state follow greater spindl power state cue moreov state state cue led reinstat target imag represent togeth result unveil behavior mechanist effect deliv remind cue specif phase endogen sleep rhythm mark import step endeavor experiment modul memori sleep
|
D000069077
|
T041
|
36,279,448
|
sea ice fluctuat baffin bay labrador sea glacial abrupt climat chang sea ice declin north atlant nordic sea propos contribut repeat abrupt atmospher warm record greenland ice core last glacial period known dansgaard oeschger event howev understand sea ice chang coupl abrupt climat chang event remain incomplet due lack suitabl high resolut sea ice proxi record northwestern north atlant region present subdecad scale bromin enrich br enr record neem ice core northwest greenland sediment core biomark record reconstruct variabl season sea ice baffin bay labrador sea suit event ka result reveal repeat shift stabl multiyear sea ice mysi condit cold stadial unstabl season sea ice condit warmer interstadi shift stadial interstadi sea ice condit occur rapid synchron atmospher warm greenland amplitud high frequenc sea ice fluctuat increas interstadi find suggest rapid replac widespread mysi season sea ice amplifi abrupt climat warm cours event highlight role feedback associ late interstadi season sea ice expans drive north atlant ocean climat system back stadial condit
|
D046448;D057231
|
T070
|
36,279,447
|
vitro evolut ribonucleas expand genet alphabet abil nucleic acid catalyz reaction well store transmit inform import basic appli scienc first context molecular evolut origin life second biomed applic howev catalyt power standard nucleic acid nas assembl four nucleotid build block limit compar protein assess evolutionari potenti librari nucleic acid six nucleotid build block reservoir catalysi compar outcom vitro select experi toward rna cleavag activ two nucleic acid librari one built standard four independ replic nucleotid six two ad nucleotid come artifici expand genet inform system aegi result compar experi suggest dna librari increas chemic divers higher inform densiti larger searchabl sequenc space one order magnitud richer reservoir molecul catalyz cleavag phosphodiest bond rna dna librari built standard four nucleotid alphabet evolv aegiszym nitro carri nucleobas z appear exploit general acid base catalyt mechan cleav bond analog mechan ribonucleas famili protein enzym heavili modifi dnazym aegiszym describ repres new type catalyst evolv librari built expand genet alphabet
|
D021881
|
T126;T116;T114
|
36,279,446
|
multipl trace alter signal nois system consolid evid fmri natur scene dataset brain mechan memori consolid remain elus examin blood oxygen level depend bold correl imag recognit scope multipl influenti system consolid theori util longitudin natur scene dataset tesla function magnet reson imag human studi trial imag recognit conduct span year among eight subject find earli late stage imag recognit associ medial tempor lobe mtl visual cortex evalu region activ multivari classifi support multipl trace theori mtt part mtl activ time cours show remark fit old mtt time dynam model predict earli trace intens increas slight subsequ interfer r find contrast simplist yet common view memori trace transfer mtl cortex next test hypothesi mtl trace signatur memori consolid also reflect synapt desatur evidenc increas signal nois ratio find magnitud relat bold enhanc among surviv memori posit link rate remov ie forget compet trace moreov imag featur time interact mtl visual cortex function connect suggest consolid mechan improv specif distribut trace neurobiolog effect replic shorter timescal within session implic prolong offlin process recognit potenti involv cognit process outsid memori retriev eg encod work larg favor mtt desatur perhap complementari consolid memori mechan
|
D008279;D001931
|
T060;T062;T170;T059
|
36,279,445
|
function sleep cognit neurosci perspect special featur explor various purpos serv sleep describ current attempt understand mani function sleep instanti neural circuit cognit structur featur reflect current expert opinion insight dynam process sleep last decad technolog advanc support updat view sleep play activ role cognit health howev role far understood collect articl evalu dynam natur sleep evolv across lifespan becom competit arena memori system influenc autonom system support consolid integr new memori lucid dream might origin set paper highlight new approach insight lay groundwork eventu understand full rang function support sleep
|
D000066494
|
T090
|
36,279,444
|
sleep depriv hippocamp rippl disrupt one session learn elimin memori express next day memori reactiv non rapid eye movement rippl thought communic new inform system wide network thus key player mediat posit effect sleep memori consolid causal experi disrupt rippl perform multiday train paradigm decreas elimin memori perform comparison sleep depriv made enabl investig develop one session learn paradigm plusmaz show disrupt either sleep gentl handl hippocamp rippl electr stimul impair long term memori furthermor detect hippocamp rippl pariet high frequenc oscil differ behavior bimod frequenc distribut cortic event observ faster cortic high frequenc oscil increas normal learn chang seen hippocamp rippl disrupt condit consist role memori consolid
|
D012892;D000069077
|
T033;T047;T046;T041
|
36,279,443
|
locat specif strategi elimin us nation racial ethnic formula see text exposur inequ air pollut level unit state decreas dramat past decad yet nation racial ethnic exposur dispar persist ambient fine particul matter formula see text investig three emiss reduct approach compar optim abil address two goal reduc overal popul averag exposur overal averag reduc differ averag exposur expos racial ethnic group versus overal popul nation inequ show nation inequ exposur elimin minor emiss reduct optim total emiss target specif locat contrast achiev outcom use exist regulatori strategi would requir elimin essenti emiss target specif econom sector possibl requir urban region meet concentr standard last find trade two goal ie reduc overal averag reduc nation inequ rather approach best reduc nation inequ ie locat specif strategi also well better two approach ie sector specif meet concentr standard reduc overal averag overal find suggest incorpor locat specif emiss reduct us air qualiti regulatori framework crucial elimin long stand nation averag exposur dispar race ethnic benefit overal averag exposur much sector specif concentr standard approach
|
D000393;D000397
|
T131;T069;T080
|
36,279,442
|
rheolog debri flow materi control distanc jam debri flow dens fast move complex suspens soil water threaten live infrastructur assess hazard potenti debri flow requir predict yield flow behavior report measur rheolog debri flow slurri high variabl sometim contradictori due heterogen particl composit volum fraction formula see text also inconsist measur method examin composit flow behavior sourc materi form postwildfir debri flow montecito ca wide rang formula see text encapsul debri flow format overland flow find shear viscos yield stress control distanc jam formula see text jam fraction formula see text materi paramet depend grain size polydispers friction rescal shear viscous stress account effect data collaps onto simpl nondimension flow curv indic bingham plastic viscoplast fluid given high nonlinear depend rheolog formula see text find suggest determin jam fraction natur materi signific improv flow model geophys suspens hyperconcentr flow debri flow
|
D012987;D014867
|
T121;T197;T167
|
36,279,441
|
definit saxitoxin stx bind code enabl discoveri character anuran saxiphilin famili american bullfrog rana castesbeiana saxiphilin rc sxph high affin toxin spong protein thought prevent intox saxitoxin stx lethal bis guanidinium neurotoxin caus paralyt shellfish poison psp block voltag gate sodium channel na v specif rc sxph interact contribut stx bind defin whether organ similar protein unclear use mutagenesi ligand bind structur studi defin energet basi sxph stx recognit result stx recognit code enabl engin rc sxph improv abil rescu na v stx facilit discoveri new frog toad sxphs definit stx bind code sxph famili expans among divers anuran separ evolut provid molecular basi understand role toxin spong protein toxin resist develop novel protein sens neutral stx relat psp toxin
|
D012530;D009498
|
T123;T131;T109
|
36,279,440
|
mercuri isotop evid import particl sourc mercuri marin organ origin methylmercuri pelag fish remain unclear mani unansw question regard product degrad neurotoxin water column use mercuri hg stabl isotop ratio marin particl biota elucid cycl methylmercuri prior incorpor marin food web hg isotop composit particl zooplankton fish reveal preferenti methyl hg within small collect equatori ocean distinct small particl resembl fecal pellet addit evid hg methyl within small particl provid statist mix model even mass independ hg hg isotop valu demonstr hg within near surfac marin organ origin combin rainfal marin particl contrast meso upper bathypelag organ major hg origin marin particl littl input wet deposit occurr methyl within marin particl support correl hg hg valu demonstr greater overlap hg isotop composit marin organ marin particl total gaseous hg wet deposit
|
D008628;D008767;D014874
|
T131;T196;T109
|
36,279,439
|
earth moon system form new insight geodynamo wide accept scenario format earth moon system involv dramat impact proto earth cosmic bodi mani featur present day earth moon system provid constraint natur impact model histori earth must account physic geochem petrolog dynam evid constraint notwithstand sever radic differ impact model could principl account evid thus absenc constraint may never know sure earth moon system form put forward idea addit constraint inde provid fact earth strong magnet univers accept earth magnet field maintain dynamo oper outer liquid core howev rapid rotat earth dynamo peculiar properti maintain strong field amplifi weak one therefor earth must magnet earli epoch either preimpact result impact either way realist model format earth moon system must includ magnet field evolut requir may ultim constrain model suffici discrimin various candid
|
D016081;D018534
|
T083;T079
|
36,279,437
|
model autonom interact hippocampus neocortex drive sleep depend memori consolid build knowledg world time mani theori memori format consolid posit hippocampus store new inform teach inform neocortex time especi sleep unclear mechanist actual work system abl interact period virtual environment input accomplish use learn shift represent provid framework think question neural network model simul serv demonstr model compos hippocampus neocort area replay memori interact one anoth complet autonom simul sleep oscil leverag support error driven learn lead use chang memori represent behavior model non rapid eye movement nrem sleep stage dynam hippocampus neocortex tight coupl hippocampus help neocortex reinstat high fidel version new attractor rem sleep stage neocortex abl freeli explor exist attractor find altern nrem rem sleep stage altern focus model replay recent remot inform facilit grace continu learn thus provid account hippocampus neocortex interact without extern input sleep drive use new cortic learn protect old knowledg new inform integr
|
D019579;D000069077
|
T041;T023;T024
|
36,279,436
|
contribut memori brain develop bioregul nap nap transit earli childhood transit multipl sleep bout day singl overnight sleep bout ie nap transit univers process human develop nap import infanc earli childhood enhanc learn memori consolid howev normal part develop transit nap understand nap transit essenti order maxim earli learn promot posit long term cognit outcom propos novel hypothesi regard cognit physiolog neural chang accompani nap transit specif posit matur hippocamp depend memori network result effici memori storag reduc buildup homeostat sleep pressur across cortex reflect slow wave activ eventu contribut nap transit hypothesi synthes evid bioregulatori mechan under nap transit shed new light import window chang develop framework use evalu multipl untest predict field sleep scienc ultim yield scienc base guidelin polici regard nap childcar earli educ set
|
D012890;D000069077
|
T033;T040;T041
|
36,279,435
|
yin yang regul stress granul caprin stress granul sgs cytoplasm biomolecular condens contain protein rnas respons stress ras gtpase activ protein bind protein gbp core sg protein caprin ubiquitin specif peptidas usp interact gbp facilit suppress sg format respect crystal structur nuclear transport factor like ntfl domain gbp complex gbp interact motif gim caprin usp show gim bind hydrophob pocket gbp moreov gim suppress liquid liquid phase separ llps gbp suggest caprin like facilit sg format via mechan thus dissect various domain caprin investig role llps vitro sg format cell c termin domain caprin underw spontan llps wherea n termin domain gim caprin suppress llps gbp oppos effect n c termin domain caprin sg format demonstr cell without endogen caprin propos n c termin domain caprin regul sg format yin yang fashion mediat dynam revers assembl sgs
|
D020365;D004265
|
T126;T116
|
36,279,434
|
sleep preferenti consolid negat aspect human memori well power evid two larg onlin experi research suggest sleep benefit memori moreov often claim sleep select benefit memori emot salient inform neutral inform howev scientist convinc relationship eg j siegel curr sleep med rep one critic overal sleep memori literatur like literatur mani studi underpow lack generaliz j cordi b rasch curr opin neurobiol thus leav evid mix confus interpret larg replic studi sore need recruit particip span various age rang background effort confirm sleep preferenti emot memori consolid benefit use well establish task found sleep select benefit memori negat emot object expens pair neutral background confirm prior work clear demonstr role sleep emot memori format second experi also use larg sampl examin whether effect general posit emot memori found particip demonstr better memori posit object compar neutral background sleep modul effect research provid strong support sleep specif benefit memori consolid specif negat inform broad affirm benefit sleep cognit
|
D008568;D000069077
|
T041
|
36,279,433
|
neural signatur vivid prospect thought modul tempor proxim intertempor decis make peopl discount futur reward multipl theori psycholog argu one reason futur event imagin less vivid immedi event therebi diminish perceiv valu provid neuroscientif evid propos first construct neural signatur vivid prospect thought use fmri dataset vivid imagin futur event orthogon valenc design appli neural signatur two addit fmri dataset use differ delay discount task show neural measur vivid declin reward delay farther futur
|
D065786
|
T055;T041
|
36,279,432
|
gaba signal enforc intestin germin center b cell differenti recent compel result indic possibl link neurotransmitt intestin mucos iga b cell respons immunoglobulin nephropathi igan pathogenesi demonstr amino butyr acid gaba transport gat defici induc intestin germin center gc b cell differenti worsen symptom igan mous model mechanist gat defici enhanc gc b cell differenti activ gaba mammalian target rapamycin complex mtorc signal addit igan patient lower gat express higher activ mtorc blood b cell correl kidney function igan patient collect studi describ gaba signal mediat intestin mucos immun previous unstudi pathogenesi mechan igan challeng current paradigm igan
|
D005922
|
T047
|
36,279,431
|
mechan aminopyridin inhibit lysosom channel tmem transmembran protein tmem evolutionarili distinct lysosom cation channel whose mutat associ develop parkinson diseas present cryoelectron microscopi structur molecular simul tmem bound aminopyridin ap known small molecul inhibitor tmem broad k channel inhibitor well drug approv food drug administr multipl sclerosi structur show ap whose mode action previous visual bind near center ion conduct pathway open state channel molecular dynam simul reveal bind site near middl transmembran potenti gradient provid rational voltag depend dissoci ap tmem interest bound ap rapid switch three predomin bind pose stabil altern interact pattern dictat twofold symmetri channel despit high dynam bind mode bound ap prevent ion permeat also water flow togeth studi provid framework ration design novel small molecul inhibitor tmem might reveal role channel human lysosom physiolog health diseas
|
D015761;D015221
|
T121;T116;T123;T109
|
36,279,430
|
plate motion dipolar geomagnet field ga paleomagnet record archiv earth geophys histori inform reconstruct ancient plate motion probe core via geodynamo report robust billion year old ga paleomagnet pole east pilbara craton western australia togeth previous result east pilbara ga pole enabl oldest reconstruct time resolv lithospher motion document latitudin drift rotat rate least motion style rate durat difficult reconcil true polar wander stagnant lid geodynam argu strong mobil lid geodynam ga addit pole includ oldest document geomagnet revers reflect stabli dipolar core generat archean dynamo
|
D055593
|
T070
|
36,279,429
|
genom wide chromatin access analysi unveil open chromatin converg evolut polyploid cotton allopolyploid result diverg genom cell believ trigger genom shock lead broad genet epigenet chang howev littl understood chromatin gene express dynam under drive forc allopolyploid examin genom wide dnase hypersensit site dhs variat domest allotetraploid cotton gossypium hirsutum gossypium barbadens aadd extant aa gossypium arboreum dd gossypium raimondii progenitor observ distinct dhs distribut g arboreum g raimondii contrast dhss two subgenom g hirsutum g barbadens show converg distribut converg distribut dhs also present wild allotetraploid gossypium darwinii g hirsutum var yucatanens absent resynthes hybrid g arboreum g raimondii suggest may common featur polyploid consequ domest polyploid reveal putat cis regulatori element cres deriv polyploid relat dhss domin sever famili includ dof erf bpc strike polyploid relat dhss deriv transpos element tes moreov observ posit correl dhs access histon mark hkme hkme hkme hkac hkac indic coordin interplay among histon modif tes cres drive dhs landscap dynam polyploid collect find advanc understand regulatori architectur plant underscor complex regulom evolut polyploid
|
D003368;D006657
|
T123;T116;T002
|
36,279,428
|
understand role central autonom activ sleep improv work memori episod memori last decad seen signific progress identifi sleep mechan support cognit studi focus link electrophysiolog event central nervous system sleep improv differ cognit domain dynam shift autonom nervous system across sleep larg overlook recent studi howev identifi signific contribut autonom input sleep cognit yet remain consider gap understand central autonom system work togeth sleep facilit cognit improv articl examin evid independ interact role central autonom activ sleep wake cognit process specif focus prefront subcort structur support work memori mechan under format hippocamp depend episod memori slow oscil switch model identifi separ compet under mechan support two memori domain synapt system behavior level propos sleep competit arena memori domain vie limit resourc experiment demonstr boost one system lead function trade electrophysiolog behavior outcom find inevit lead question suggest area futur research better understand brain bodi interact support wide rang cognit domain singl sleep episod
|
D008570;D061212
|
T041
|
36,279,427
|
biochronolog south african hominin bear site reassess use cercopithecid primat despit recent advanc chronometr techniqu eg uranium lead u pb cosmogen nuclid electron spin reson spectroscopi esr consider uncertainti remain regard age mani plio pleistocen hominin site includ sever south africa consequ biochronolog remain import assess plio pleistocen geochronolog provid direct age estim fossil histor cercopithecid monkey among use taxa biochronolog earli hominin wide present abund african plio pleistocen record last major studi use cercopithecid publish ago sinc new hominin site discov radiometr age estim refin mani chang occur cercopithecid taxonomi systemat thus biochronolog reassess use cercopithecid long overdu provid revis base recent studi everi major cercopithecid collect african plio pleistocen site addit correl base share faunal element present analysi base dentit abund cercopithecid theropithecus oswaldi increas size manner strong correl geolog age r therebi provid high accur age estim tool previous util combin paleomagnet u pb data result provid revis age estim suggest hominin site south africa signific older conflict age estim exist suggest addit data need recal faunal estim ultim prove reliabl past eg age kbs tuff
|
D015186;D014501;D016671
|
T196;T015
|
36,279,426
|
ornithin decarboxylas support ilc respons infecti autoimmun coliti posit regul il transcript group innat lymphoid cell ilc rort lymphocyt predomin enrich mucos tissu produc il il innat counterpart th cell th lymphocyt util uniqu metabol pathway differenti program unknown whether ilc make similar metabol adapt employ singl cell rna sequenc metabolom profil intestin ilc subset identifi enrich polyamin biosynthesi ilc converg rate limit enzym ornithin decarboxylas odc vitro vivo studi demonstr exogen supplement polyamin putrescin biosynthet substrat ornithin enhanc ilc product il condit delet odc ilc impair mous antibacteri defens citrobact rodentium infect associ decreas anti microbi peptid product intestin epithelium furthermor model anti cd coliti defici odc ilc mark reduc product il sever inflammatori coliti conclud ilc intrins polyamin biosynthesi facilit effici defens enter pathogen well exacerb autoimmun coliti thus repres attract target modul ilc function intestin diseas
|
D003092;D004756
|
T047
|
36,279,425
|
baboon perspect ecolog behavior earli human ancestor research look baboon monkey genus papio sourc hypothes ecolog behavior earli hominin earli human ancestor close relat approach undergon resurg last decad result rapid increas knowledg experiment field studi baboon archeolog paleontolog studi hominin result rich array analog scenario stimuli thought ecolog behavior earli hominin main intent illustr baboon perspect earli hominin emphasi recent develop begin discuss baboon hominin know current explain reason draw comparison includ occup divers environ combin arbor terrestri capabl relat larg bodi size sexual dimorph remaind paper illustr main point small number exampl drawn divers area interest diet grass fish danger leopard crocodil social organ troop multilevel societi social relationship male male male femal femal femal communic possibl foundat languag cognit use social inform comparison self other biped specul development hypothesi neurolog basi conclus optimist futur baboon perspect earli hominin
|
D015186
|
T015
|
36,279,424
|
decad migrat phenolog long live arctic icon keep pace climat chang anim migrat respons season environ reproduc benefit resourc puls avoid fluctuat hazard although climat chang predict modifi migrat studi date demonstr phenolog shift marin mammal arctic marin mammal consid among sensit ongo climat chang due narrow habitat prefer long life span longev may prove obstacl speci evolutionarili respond speci exhibit high site fidel strong associ migrat rout adjust time migrat one recours avail respond chang climat demonstr evid signific delay time narwhal autumn migrat satellit track data span canadian arctic measur migrat phenolog vari annual explain sex climat driver associ ice condit suggest narwhal adopt strateg migrat tactic male narwhal found lead migrat summer area femal potenti depend young depart later narwhal remain longer summer area rate per decad similar rate observ climat driven sea ice loss across region consequ alter space use time yet evalu expos individu increas natur chang anthropogen activ summer area
|
D057231;D046448
|
T070
|
36,279,419
|
character ultrapot chemogenet ligand research applic nonhuman primat chemogenet techniqu obtain select pharmacolog control cell popul express engin receptor select activ exogen administ ligand promis approach neuron modul involv use pharmacolog select actuat modul psam chemogenet receptor select activ ultrapot pharmacolog select effector molecul upsem extend use psampsem studi nonhuman primat necessari thorough character efficaci safeti tool describ time cours brain penetr rhesus monkey two compound promis bind specif efficaci profil vitro studi upsem upsem system administr rhesus monkey receiv subcutan sc intraven iv administr upsem mgkg upsem mgkg plasma cerebrospin fluid sampl collect h compound exhibit good brain penetr relat slow washout neglig convers potenti metabolitesvareniclin hydroxyvareniclin addit found neither upsem signific alter heart rate sleep result indic compound suitabl candid neurosci studi use psam nonhuman primat
|
D009474;D001921
|
T023;T025
|
36,279,418
|
algorithm differenti autom model machin learn forc field reconstruct forc field ffs atomist simul data challeng sinc accur data high expens machin learn ml model help data econom success constrain use under symmetri conserv law physic howev far everi descriptor newli propos ml model requir cumbersom mathemat tedious remodel therefor propos use modern techniqu algorithm differenti within ml model process effect enabl usag novel descriptor model fulli automat order magnitud higher comput effici paradigmat approach enabl versatil usag novel represent effici comput larger systemsal high valu ff communitybut also simpl inclus physic knowledg higher order inform eg hessian complex partial differenti equat constraint etc even beyond present ff domain
|
D000069550
|
T066
|
36,279,412
|
preferenti adsorpt promin amino acid ureas enzym sporosarcina pasteurii arid soil compon period dft studi ureas enzym common use microbi induc carbon precipit micp enzym induc carbon precipit eicp heal strengthen soil improv understand adsorpt ureas enzym various soil surfac lead advanc micp eicp engin method well area soil scienc work use densiti function theori dft investig ureas enzym bind abil four common arid soil compon quartz corundum albit hematit ureas enzym direct simul dft due size amino acid compris least ureas enzym simul instead adsorpt model incorpor gibb free energi use determin exist amino acid miner bind mode found nine simul amino acid bind preferenti differ soil compon alanin favor corundum glycin threonin favor hematit aspart acid favor albit found standard environment condit consid amino acid bind quartz unfavor polymer form side chain would domin bind interact hematit favor aspart acid r oh group corundum favor glutam acid r ket group overal model predict ureas enzym produc sporosarcina pasteurii bind various oxid found arid soil alanin glycin asparticglutam acid threonin residu
|
D014510;D012987
|
T126;T116;T167
|
36,279,406
|
salt effect donnan equilibrium montmorillonit demonstr molecular dynam simul donnan equilibrium govern distribut ion mani system ion exchang membran biolog cell contact extern electrolyt herein donnan equilibrium bulk salt solut bihydr montmorillonit investig system great import mani nuclear wast dispos concept specif use molecular dynam simul determin partit coeffici chlorid achiev calcul free energi differ chlorid interlay bulk use enhanc sampl methodolog montmorillonit equilibrium either nacl cacl examin elucid general differ salt concentr depend partit coeffici salt determin use three four concentr nacl cacl respect case nacl found partit coeffici increas linear concentr cacl increas proport squar root concentr deriv partit coeffici use general donnan theori includ excess free energi contribut beyond electrostat donnan potenti also present salt agreement partit coeffici simul donnan theori excel although donnan theori continuum theori deriv without refer atomist detail present result justifi applic system nanoscal pore
|
D012965;D012492
|
T121;T104;T196;T197;T130
|
36,279,405
|
fast electron detach dissoci oligonucleotid electron nitrogen plasma store magneto radio frequenc ion trap report plasma electron detach dissoci edd novel electron activ dissoci ead method fast sequenc oligonucleotid high sequenc coverag reduc repuls coulomb forc deproton oligonucleotid electron beam perform edd neutral electron nitrogen n plasma store magneto radio frequenc ion trap confirm plasma edd accomplish high sequenc coverag rna mer reaction time ms use electron beam kinet energi ev new techniqu appli various modif oligonucleotid therapeut ont phosphorothio ps posit show extrem high dissoci effici ie time higher standard phosphat po dna lock nucleotid show intens dissoci edd howev collis induc dissoci cid help sequenc portion liquid chromatographi tandem mass spectrometri lc msms use zenotof mass spectromet equip plasma edd techniqu success identifi impur degrad sampl
|
D004583;D009841
|
T081;T196;T114
|
36,279,403
|
comput thermodynam properti fluid augment nanoconfin applic pressur methan nanoconfin fluid exhibit remark differ thermodynam behavior compar bulk phase confin effect render predict thermodynam quantiti nanoconfin fluid challeng particular confin creat spatial vari densiti profil near wall primarili respons adsorpt capillari condens behavior signific fluctuat thermodynam quantiti inher nanoscal system coupl strong fluid wall interact give rise near wall densiti profil empir model propos explain model effect yet first principl base formul develop present statist mechan framework emb coupl describ effect fluid wall interact amplifi near wall densiti behavior compress gase elev pressur pressur methan confin show propos theori predict accur adsorb layer thick obtain small angl neutron scatter measur furthermor predict densiti confin propos theori shown excel agreement avail experiment atomist simul data rang temperatur nanoconfin methan framework present evalu near wall densiti owe rigor foundat statist mechan propos theori also general predict phase transit nonequilibrium transport nanoconfin fluid
|
D008697
|
T109
|
36,279,398
|
pediatr septic shock recognit manag emerg depart sepsi lead caus morbid mortal children earli recognit time initi empir broadspectrum antibiot crystalloid fluid administr associ better outcom although evid diagnosi treatment septic shock first generat adult studi clear pediatr studi need manag septic shock children issu provid guidanc manag septic shock children focus earli recognit appropri resuscit
|
D012772;D018805
|
T047;T046
|
36,279,397
|
differenti activ desensit state promot noncanon nicotin acetylcholin receptor agonist seri dipicolyl amin pyrimidin dpps previous identifi potenti agonist mean calcium influx assay presenc posit alloster modul pam chloro dimethoxi phenyl methyl isoxazol yl urea pnu compound lack quaternari strong basic nitrogen typic nicotin agonist although differ structur typic nicotin agonist base crystallograph data acetylcholin bind protein appear engag site share typic orthoster agonist use oocyt express human receptor found dpps efficaci activ receptor current show rapid desensit characterist receptor howev note rate recoveri desensit depend strong structur featur within dpp famili although activ receptor dpp block competit antagonist methyllycaconitin mla mla effect dpp induc desensit suggest multipl mode dpp bind expect desensit conform state could reactiv pam mutant made insensit acetylcholin ca mutat agonist bind site weak activ dpps observ activ ca mutant dpp compound resist alloster antagonist cis tran tetramethylphenyl ab tetrahydro h cyclopenta c quinolin sulfonamid support hypothesi activ noncanon agonist orthoster bind site entir depend classic epitop control activ typic agonist perhap may access altern mode promot conform chang associ activ desensit signific statement studi report famili nicotin acetylcholin receptor agonist break rule structur nicotin acetylcholin receptor agonist show activ noncanon agonist orthoster bind site depend classic epitop control activ typic agonist differ bind pose promot uniqu conform chang associ receptor activ desensit
|
D011804;D011978
|
T192;T116;T109
|
36,279,396
|
renoprotect effect tanshinon iia kidney injuri induc ischemia reperfus obes rat obes enhanc frequenc sever acut kidney injuri aki induc renal ischemia reperfus ir tanshinon iia tiia pre treatment use allevi renal injuri induc renal ir whether tiia attenu renal cell apoptosi via modul mitochondri function pikaktbad pathway obes rat examin
|
D058186;D015428
|
T047;T046;T037
|
36,279,395
|
identif circrna mirna mrna network explor molecular mechan immun regul postop neurocognit disord postop neurocognit disord pnd common complic older patient howev pathogenesi still remain elus recent studi shown circular rna circrna play import role develop neurodegen diseas pnd surgeri circrna competit endogen rna cerna main act molecular spong mirna adsorb microrna mirna reduc inhibitori effect mirna target mrna sequenc data circrna obtain gene express omnibus geo databas bioinformat method circatla mirdb mirtarbas mirwalk databas appli construct circrna mirna mrna network screen differenti express mrnas improv accuraci data random divid age mice control non pnd group pnd group use high throughput sequenc analyz brain hippocamp tissu analysi three key gene cross detect data group uncc tbx stsia hub gene provid new target pnd treatment accord result gene ontolog go kyoto encyclopedia gene genom kegg pathway enrich analys immun cell infiltr analysi gene set enrich analysi gsea connect map cmap analysi quantit real time polymeras chain reaction qrt pcr gene relat central nervous system remov final mmucircmir puncc mmucircmir pstsia cerna network identifi addit cmap method use select top activ compound largest negat correl absolut valu includ cimaterol rucaparib fg hydrocortison
|
D000079962;D035683
|
T123;T114
|
36,279,394
|
network analysi identif hub gene relat molecul potenti biomark associ differenti bone marrow deriv stem cell hepatocyt incid liver diseas increas steadili howev shortcom high cost organ donor scarciti applic stem cell research brought new idea treatment liver diseas therefor particular import clarifi molecular regulatori mechan differenti bone marrow deriv stem cell bmscs liver cell herein screen differenti express gene hepatocyt untreat bmscs identifi gene respons differenti bmscs hepatocyt gse gene microarray data bmscs gse gene microarray data primari hepatocyt obtain gene express omnibus databas transcriptom analysi consol softwar show gene upregul downregul hepatocyt compar bmscs hub gene analyz use string cytoscap v reveal twenti four hub gene play pivot role differenti bmscs hepatocyt express hub gene bmscs hepatocyt verifi revers transcript quantit pcr rt qpcr next target mirna hub gene predict lncrnas regul mirna discov thus form lncrna mirna mrna interact chain result indic lncrna mirna mrna interact chain may play import role differenti bmscs hepatocyt provid new therapeut target liver diseas treatment
|
D062085;D035683
|
T123;T114
|
36,279,393
|
associ epstein barr virus serolog reactiv psycholog distress cross section studi japanes communiti dwell older adult reactiv epstein barr virus ebv associ etiopathogenesi broad spectrum diseas studi aim investig associ psycholog distress ebv serolog reactiv among communiti dwell older peopl assess role sex differ associ popul base cross section survey conduct among individu underw annual health checkup n median age year ebv serolog reactiv defin elev ebv earli antigen immunoglobulin g titer psycholog distress defin kessler score multivari logist regress analysi perform calcul odd ratio confid interv ci ebv serolog reactiv psycholog distress ebv serolog reactiv psycholog distress detect particip respect women account ebv serolog reactiv multivari logist regress analysi show psycholog distress signific associ ebv serolog reactiv among particip ci p sex stratifi multivari analysi show posit associ among women ci p associ among men ebv serolog reactiv independ associ psycholog distress communiti dwell older women sex differ result warrant investig clarifi physiolog mechan under associ
|
D004854;D020031
|
T005;T047
|
36,279,392
|
murin central nervous system bone marrow distribut aurora kinas inhibitor alisertib pharmacokinet exposur site efficaci toxic import challeng develop drug target central nervous system cns tumor includ overcom barrier cns deliveri reduc system side effect alisertib aurora kinas inhibitor examin treatment sever cns tumor preclin clinic studi studi investig distribut alisertib cns site efficaci brain tumor bone marrow site dose limit toxic lead myelosuppress mechan influenc site specif distribut activ transport mediat efflux protein p glycoprotein p gp breast cancer resist protein bcrp examin alisertib exposur brain wild type mice less plasma even distribut throughout various brain region spinal cord studi use transport knockout mice pharmacolog inhibit show alisertib cns distribut influenc p gp bcrp convers upon system administr alisertib distribut bone marrow occur rapid signific limit efflux transport reach higher concentr cns studi demonstr given equival distribut drive forc exposur plasma exposur alisertib brain signific less bone marrow suggest target deliveri may necessari guarante therapeut efficaci minim risk advers eventstherefor data suggest improv therapeut index use alisertib brain tumor local region deliveri convect enhanc deliveri may warrant signific statement cns penetr alisertib limit uniform distribut various region brain p gp efflux import mechan limit cns distribut alisertib rapid distribut bone marrow site toxic greater exposur cns possibl site efficaci result suggest need design local deliveri strategi improv cns exposur alisertib limit system toxic treatment brain tumor
|
D064096;D001932
|
T191;T126;T116
|
36,279,379
|
emerg depart manag surgic airway complic emerg clinician often respons acut manag complic pertain acut difficult airway chronic surgic airway howev clinic knowledg andor experi may lack review provid overview surgic airway complic result mechan infecti hematolog caus provid best practic recommend current consensus guidelin manag difficult airway indic surgic airway discuss
|
D058109;D004636
|
T061;T073;T093
|
36,279,314
|
activ integr conjug element tn caus growth arrest death host bacteria integr conjug element ice serv major driver bacteri evolut element often confer benefit host cell includ antibiot resist metabol capabl pathogen determin ice also negat effect host cell investig effect ice conjug transposon tn host cell tn activ relat small subpopul host cell develop fluoresc report system monitor activ tn singl cell use report found cell divis arrest cell bacillus subtili enterococcus faecali natur host tn contain activ excis tn furthermor cell activ tn subsequ die also observ phenotyp popul level b subtili util modifi version tn activ major cell identifi two gene orf orf tn suffici caus growth defect b subtili identifi singl gene yqar defect phage skin b subtili chromosom requir phenotyp three gene partial respons growth defect caus tn indic tn possess multipl mechan affect growth viabil host cell result highlight complex relationship conjug element host cell interplay mobil genet element
|
D003227;D004251
|
T045;T123;T114;T086
|
36,279,312
|
phosphoinositid speci filament actin format mediat engulf senesc tumor cell cancer cell surviv chemotherapi caus lethal relaps enter senesc state facilit express mani phagocytosismacrophag relat gene engend novel cannib phenotyp use biosensor live cell imag reveal basic step mechan engulf senesc human mous tumor cell show filament actin predat cell local prey cell throughout process engulf biosensor various phosphoinositid pi speci reveal increas concentr distinct local predat pi p pi p prey cell earli stage engulf follow transient burst pi p follow intern pikcb kinas respons generat pi p requir complet engulf inhibit knockdown clathrin known associ pikcb pi p sever impair engulf sum data reveal fundament cellular process senesc cell engulf includ precis local dynam actin pi speci throughout entir process
|
D000199;D008841
|
T026;T123;T116
|
36,279,310
|
stromal homeostasi restor nanomedicin enhanc pancreat cancer chemotherapi desmoplast stroma impos fatal physic deliveri barrier pancreat ductal adenocarcinoma pdac therapi deconstruct stroma compon henc predomin stroma target approach conflict outcom sometim occur due multifacet natur stroma construct two sub nm nanomedicin base call next wave antifibrot halofuginon hf tumoricid paclitaxel ptx enhanc pdac chemotherapi achiev coassembl methoxi poli ethylen glycol b poli caprolacton ketal link hf ptx deriv prodrug hf nanomedicin ptx nanomedicin excel prodrug nanocarri compat exhibit great improv pharmacokinet profil high tumor accumul hf nanomedicin pretreat restor stromal homeostasi consider facilit distribut ptx nanomedicin penetr carcinoma cell lead posit modul infiltr cytotox cell signific regress tumor growth two pdac model nanomedicin base stromal remodel strategi appear promis treat desmoplast malign
|
D010190;D021441;D011355
|
T120;T191
|
36,279,309
|
mechan lung cancer finit element model show strain amplif earli tumorigenesi earli lung cancer lesion develop within uniqu microenviron undergo constant cyclic stretch respir tumor stiffen establish driver tumor progress contribut stress strain lung cancer unknown develop tissu scale finit element model lung tissu test earli lesion alter respir induc strain found earli tumor repres alveolar fill amplifi strain experienc adjac alveolar wall tumor stiffen increas amplitud strain adjac alveolar wall extend strain amplif deeper normal lung contrast strain experienc tumor proper less appli strain although region amplif appear tumor edg measur alveolar wall thick clinic mous model sampl lung adenocarcinoma luad show wall thicken adjac tumor consist cellular respons strain model alveolar wall thicken encircl tumor thicken wall move strain amplif radial outward next adjac alveolus simul iter thicken respons amplifi strain produc track thicken wall observ track earli stage clinic sampl track popul invad tumor cell suggest strain amplif earli lung lesion could guid pro invas remodel tumor microenviron simul result tumor measur suggest cell edg lung tumor surround alveolar wall experi increas strain respir could promot tumor progress
|
D011650;D008175
|
T023;T191
|
36,279,308
|
mutagenesi structur model implic rme iwn domain conform control point endocytosi transmembran cargo differenti sort degrad recycl pathway process facilit recruit physic distinct degrad recycl microdomain limit membran individu endosom endosom sort complex requir transport escrt mark degrad microdomain recycl domain mark retrom complex associ protein rme snx separ endosom microdomain also control rme snx least part via remov degrad compon hrshgrs recycl microdomain activ like due recruit activ chaperon hsc endosom rme dnaj domain better understand mechan rme function perform new phylogenet analysi rme identifi new conserv sequenc featur complementari approach perform structur function analysi identifi c terminus import microdomain local like substrat bind n termin sequenc beyond known singl n termin ph like domain import endosom recruit random mutagenesi identifi iwn analog iwn import autoinhibitori dnaj domain bind iwn play critic role hrs uncoat activ combin alphafold structur predict vivo mutat analysi rme propos model wherebi snx iwn domain control conform rme henc product exposur dnaj domain furthermor propos activ rme cyclic snx act activ target rme uncoat activ
|
D011992;D004705
|
T026;T043
|
36,279,307
|
stream potenti hyaluron acid hydrogel film stream potenti hyaluron acid ha hydrogel film measur theoret interpret systemat vari ha concentr stream electrolyt ph ionic strength donnan potenti expect vanish suffici ad salt appar potenti helmholtz smoluchowski interpret remain order mv theoret interpret data deriv electrokinet model valid deby hckel regim account ionic hydrodynam permeabl gel film could ascrib effect acid dissoci constant p k specif ha charg e mmol g brinkmanhydrodynam permeabl l l l brinkman length ha solut prepar refer state hydrogel swell ratio ionic strength mmol l exampl ha surfac potenti mv donnan potenti consider lower potenti furnish helmholtz smoluchowski interpret insight signific chang film expect interact surfac colloid via derjaguin landau vervey overbeek type forc analysi furnish formula swell ratio hydrodynam permeabl l express explicit simpl power law function prepar ha concentr c ha wt consist independ assess ha solut permeabl polyelectrolyt hydrogel swell theori may prove valuabl extrapol result combin ionic strength ph ha cross link concentr
|
D006820;D008756
|
T123;T122;T121;T109
|
36,279,305
|
chronic deplet vertebr lipid aed aegypti cell dysregul lipid metabol inhibit innat immun without alter dengu infect aed aegypti primari vector dengu virus denv arbovirus previous literatur suggest vertebr invertebr lipid nutrit status mosquito modifi virus infect develop vertebr lipid deplet ae aegypti cell line investig chronic deplet vertebr lipid normal present blood meal insect cell cultur medium would impact cell growth virus infect chronic deplet vertebr lipid reduc cell size prolifer although cell retain equival total intracellular lipid per cell reduc lipolysi modifi gene express relat sugar lipid metabol downregul innat immun gene also observ hypothes chronic deplet vertebr lipid would impact virus infect howev amount denv produc per cell studi reveal ae aegypti cell adapt absenc vertebr lipid denv replic equal well cell contain predomin vertebr invertebr lipid
|
D000330;D003716;D003715
|
T005;T204;T047
|
36,279,303
|
structur spine plastic learn forget odor specif subnetwork olfactori bulb learn discrimin differ sensori stimuli essenti surviv rodent olfactori bulb contribut odor discrimin via pattern separ exhibit extens structur synapt plastic involv format remov synapt spine even adult anim network connect result plastic still poor understood gain insight connect present comput model structur plastic reciproc synaps domin popul excitatori princip neuron inhibitori interneuron incorpor observ modul spine stabil odor exposur model captur strike experiment observ exposur odor alway enhanc discrimin train similar odor enhanc discrimin train dissimilar odor actual reduc discrimin train stimuli strike differenti learn requir activ depend spine stabil occur also model pure random spine dynam spine densiti chang homogen eg due global signal howev experiment observ odor specif reduct respons princip cell result extend odor exposur concurr disinhibit subset princip cell aris activ depend model moreov model predict experiment testabl recoveri odor respons weak strong odor exposur forget odor via exposur interf odor combin experiment observ comput model provid strong support predict odor exposur lead format odor specif subnetwork olfactori bulb
|
D009830;D009812
|
T120;T023;T070
|
36,279,302
|
understand impact third parti speci pairwis coexist persist virtual everi singl speci depend presenc speci specif environment condit given locat natur set mani condit unknown research center find fraction possibl condit probabl lead speci coexist focus persist probabl entir multispeci communiti form either two speci howev methodolog philosoph question alway whether observ entir communiti condit observ subset communiti persist part larger multispeci system deriv long term use analyt calcul short term use simul experiment data system level indic effect third parti speci coexist probabl pair subset speci unknown environment condit demonstr fraction condit incompat possibl coexist pair speci tend becom vanish small within system increas number speci yet probabl pairwis coexist isol remain approxim expect probabl pairwis coexist divers assemblag addit found third parti speci tend reduc resp increas coexist probabl pair tend exhibit slower resp faster rate competit exclus long term short term effect remain third parti speci possibl specif pair system equal distribut differ map anticip environment uncertainti
|
D017753;D008954
|
T075;T070;T082
|
36,279,301
|
total synthesi principinol c achiev first total synthesi principinol c possess intrigu complex tetracycl skeleton eight contigu stereocent tetracycl skeleton principinol c assembl use intramolecular pauson khand reaction key step synthet rout repres first applic intramolecular pauson khand reaction enyn construct bicycl ring system natur product synthesi
|
D001688
|
T123;T121
|
36,279,300
|
accept ambit cm treatment regimen hiv associ cryptococc mening find qualit method studi particip research botswana uganda ambit cm trial hiv associ cryptococc mening demonstr singl high dose liposom amphotericin ambisom plus day oral flucytosin fluconazol non inferior term caus mortal day amphotericin b deoxychol flucytosin follow day fluconazol control ambisom regimen associ fewer advers event explor accept ambisom regimen perspect particip provid
|
D016919;D015658
|
T047
|
36,279,299
|
effect integr care older adult depress hypertens rural china cluster random control trial effect integr care manag common comorbid physic mental disord insuffici examin low middl incom countri lmic test hypothes older adult treat rural chines primari care clinic integr care manag comorbid depress hypertens htn would show greater improv depress symptom sever htn control receiv usual care
|
D006973;D019033
|
T047;T058;T093
|
36,279,298
|
systemat review meta analysi human zoonot dog soil transmit helminth infect australian indigen communiti soil transmit helminth sth infect billion peopl countless anim worldwid australian indigen communiti sth infect larg remain endem despit control effort suggest reservoir infect may exist dog fulfil various import cultur social occup role australian indigen communiti popul set dog may also harbour zoonot sths capabl produc morbid mortal dog human review provid overview human zoonot sth infect identifi australian indigen locat affect parasit speci host involv meta analysi provid estim individu studi pool true preval sth infect australian indigen communiti identifi knowledg gap research zoonot anthroponot potenti systemat literatur search identifi elig studi document presenc strongyloid stercorali trichuri trichiura ancylostoma caninum ancylostoma duodenal ancylostoma ceylanicum undifferenti hookworm ascari lumbricoid studi also elig inclus meta analysi establish true preval light imperfect diagnost test sensit specif rogan gladen bayesian method studi reveal pool true preval estim ci human canin stercorali infect ci canin caninum infect indic continu endem consider heterogen pool estim canin ceylanicum infect duodenal undifferenti hookworm trichiura human review suggest preval sths australian indigen communiti like underestim princip base imperfect diagnost test potenti misclassif hookworm speci human dog due outdat methodolog also obscur pictur high qualiti contemporari studi requir establish current true preval parasit speci relev host guid futur polici develop control decis cultur sound one health framework
|
D006376;D006373;D006725
|
T047;T204
|
36,279,296
|
tort tradeoff case pesticid drift legal econom analysi widespread pesticid drift issu ensu advent dicamba toler crop system late result million acr damag farmland farmer suffer drift relat loss crop yield seek recoveri state court howev state court vari approach drift lawsuit remedi award could includ damag award injunct demonstr need transpar judici process paper identifi three tort common advanc caus action drift case creat theoret game model evalu tort impact farmer decis make econom outcom
|
D016365;D010575
|
T078;T131;T089;T080
|
36,279,295
|
variant apol protein plasma associ larger particl human mous model kidney injuri genet variant apolipoprotein l apol protein protect human infect african trypanosom explain substanti proport excess risk chronic kidney diseas affect individu sub saharan ancestri mechan risk variant damag kidney cell remain incomplet understood preclin model apol express podocyt lead signific kidney injuri human studi kidney transplant suggest effect apol variant predomin driven donor genotyp less attent paid possibl role circul apol kidney injuri
|
D000075944;D051436
|
T047;T116
|
36,279,294
|
intracellular acidif hallmark thymineless death e coli thymidin starvat caus rapid cell death enigmat process known thymineless death tld under kill mechan divers antimicrobi antineoplast drug despit decad investig still lack mechanist understand causal sequenc event culmin tld use divers set unbias approach systemat determin genet regulatori underpin tld escherichia coli addit discov novel gene previous implic pathway studi reveal critic previous unknown role intracellular acidif tld observ decreas cytoplasm ph robust earli event tld across differ genet background furthermor show acidif causal event death process chemic genet perturb increas intracellular ph substanti reduc kill also observ decreas intracellular ph respons exposur antibiot gentamicin suggest intracellular acidif may common mechanist step bactericid effect antibiot
|
D004926;D013941
|
T123;T007;T114
|
36,279,293
|
isol barcod trace pollen free dna authent honey adulter mislabel honey mask true origin becom global concern pollen microscopi current gold standard identifi honey geograph plant origin labori requir extens train fail identifi filter honey honey spike pollen favor plant disguis origin success isol pollen free dna filter honey use three type adsorb anti dsdna antibodi coupl magnet microspher ii anion exchang adsorb iii ceram hydroxyapatit intern transcrib spacer region captur pollen free dna polymeras chain reaction amplifi subject next generat sequenc use hous bioinformat pipelin initi experi show anion exchang greatest capac captur trace pollen free dna success appli isol dna five honey sampl enrich trace pollen free dna filter honey sampl open new approach identifi true origin honey
|
D006722
|
T168
|
36,279,292
|
model covid pandem vaccin mutant virus paper propos compart model sveihrm model base system ordinari differenti equat simul pandem sever acut respiratori syndrom coronavirus sar cov emerg mutant virus gave rise multipl peak number confirm case vaccin develop suggest individu receiv multipl vaccin primari secondari vaccin booster shot mitig transmiss covid take account includ compart multipl vaccin mutant virus covid model particular model consid breakthrough infect accord antibodi format rate follow multipl vaccin obtain effect reproduct number origin virus delta omicron variant fit model data korea addit provid various simul adjust daili vaccin rate time vaccin investig effect two vaccin relat measur number infect individu also show start vaccin earli key reduc number infect individu delay start date requir increas substanti rate vaccin achiev similar target result sensit analysi vaccin rate korean data shown increas decreas vaccin rate reduc increas number confirm case respect
|
D000086382;D014765
|
T129;T047;T121;T067
|
36,279,291
|
genom wide meta analysi qtl morpholog relat trait flag leaf bread wheat flag leaf import organ photosynthesi wheat plant key factor affect wheat yield studi quantit trait loci qtl flag leaf morpholog trait wheat report sinc collect investig genet mechan trait integr qtls various map popul high densiti consensus map compos various type molecular marker well qtl meta analysi discov meta qtls mqtl control morpholog trait flag leav mqtls confirm gwas four high confid mqtls mqtl mqtl mqtl mqtl screen mqtls averag confid interv cm physic distanc mb accord definit hcmqtl ten wheat ortholog rice arabidopsi regul leaf angl develop morphogenesi trait identifi hcmqtl region use compar genom specul potenti candid gene regul flag leaf morpholog trait wheat result studi provid valuabl inform fine map molecular marker assist select improv morpholog charact wheat flag leaf
|
D040641;D014908
|
T168;T002;T028
|
36,279,290
|
catalysi enabl step total synthesi peyssonnosid report step enantioselect stereoselect total synthesi peyssonnosid uniqu diterpen glucosid rare high congest pentasubstitut cyclopropan promis antimicrobi activ among step synthes peyssonnosol aglycon peyssonnosid eight transit metal catalyz transform enabl construct new c c bond stereocent without involv protect group notabl palladium catalyz dearom cyclize use build c spiro carbon quaternari center counterintuit hydrogen atom transfer hat initi reduct olefin cross coupl realiz forg pentasubstitut cyclopropan ring excel stereoselect
|
D003521;D010165
|
T196;T109
|
36,279,289
|
apprehens educ outcom among hispan student unit state impact secur communiti prior research suggest disrupt event shock induc famili instabl neighborhood violenc reloc tend detriment children educ outcom find heterogen depend type event limit evid avail shock result immigr enforc impact educ outcom among target minor group studi contribut literatur assess polici implement us secur communiti relat school district level achiev hispan student secur communiti program nation level immigr enforc polici roll counti counti basi program increas risk deport led rise apprehens insecur among undocu migrant wider hispan communiti use detail inform implement secur communiti data stanford educ data archiv current popul survey studi estim dynam differ differ exploit region variat time polici chang assess impact educ outcom result show activ secur communiti negat associ hispan student subsequ english languag art achiev white black student achiev chang find suggest hispan student live south rural area area high proport like undocu migrant disproportion impact program activ wherea hispan student sanctuari jurisdict reduc likelihood deport impact find indic immigr enforc negat consequ educ social inequ unit state
|
D006630;D014171
|
T098
|
36,279,288
|
model first wave covid india estim burden covid india difficult extent case death undercount hard assess use compon age stratifi contact structur epidemiolog compartment model call indsci sim model analys first wave covid spread india use indsci sim togeth bayesian method obtain optim fit daili report case death across span first wave indian pandem period jan feb account lock down non pharmaceut intervent npis overal increas test function time count case death rang age specif infect fatal ratio first use model describ data individu district state karnataka benchmark calcul use data serolog survey extend approach aggreg data karnataka state model progress pandem across citi delhi mumbai pune bengaluru chennai india whole estim death undercount factor across span first wave converg repres multipli account urban rural gradient also estim overal count case factor toward end first wave estim infect fatal ratio ifr rang broad consist previous estim substanti lower valu estim lmic countri find approxim india infect overal end first wave result broad consist serosurvey result contribut understand long term trajectori covid india
|
D000086382
|
T047;T067
|
36,279,287
|
use compress sens expedit high throughput diagnost test covid beyond rapid spread sar cov place signific burden public health system provid swift accur diagnost test highlight critic need innov test approach futur pandem studi present novel sampl pool procedur base compress sens theori accur identifi viral infect patient high preval rate util innov viral rna extract process minim sampl dilut preval rate rang number test requir identifi infect status patient reduc compar convent test primari human sar cov nasopharyng swab coronavirus model system method provid quantif individu sampl viral load within pool well binari posit negat result addit modifi pool rna extract process minim sampl dilut remain constant pool size increas compress sens adapt wide varieti diagnost test applic increas throughput routin laboratori test well mean increas test capac combat futur pandem
|
D000086382
|
T047;T067
|
36,279,286
|
three fold util supplementari inform mean estim median rank set sampl scheme rank set sampl rss creat broad interest among research still uniqu research topic long last begun find way practic applic beyond initi horticultur base birth fundament paper mcintyr nineteenth centuri one extens rss median rank set sampl mrss mrss sampl procedur normal util measur variabl interest troublesom expens wherea might easi rank unit use inexpens sort criterion sever research introduc ratio regress exponenti differ type estim mean estim mrss design paper propos three new mean estim mrss scheme idea base three fold util supplementari inform specif util rank second raw moment supplementari inform origin valu supplementari variabl appropri propos group estim demonstr light real artifici data set base mont carlo simul addit perform comparison also conduct regard review famili estim result empow predomin execut propos group estim seen throughout paper
|
D015233
|
T081;T170
|
36,279,285
|
cd mediat restrict sar cov infect macrophag induc pro inflammatori respons exacerb persist innat immun respons mark pro inflammatori cytokin express thought major driver chronic covid patholog although macrophag primari target cell sar cov infect human viral rna antigen activ monocyt macrophag detect post mortem sampl dysfunct monocyt macrophag hypothes contribut protract hyper inflammatori state covid patient studi demonstr cd myeloid cell specif type lectin facilit ace independ sar cov fusion entri macrophag cd mediat sar cov entri macrophag result express viral genom subgenom rnas minim viral protein express infecti viral particl releas suggest post entri restrict sar cov replic cycl intrigu post entri replic block allevi exogen ace express macrophag restrict express viral genom subgenom rna cd macrophag elicit pro inflammatori cytokin express tnf il il rig mda mav depend manner suppress remdesivir treatment find suggest de novo express sar cov rna macrophag contribut pro inflammatori cytokin signatur block cd mediat ace independ infect subsequ activ macrophag viral rna might allevi covid associ hyperinflammatori respons
|
D000086382
|
T047;T067
|
36,279,284
|
ican interpret cross attent network identifi drug target protein interact drug target protein interact dti identif fundament drug discoveri drug reposit therapeut drug act diseas caus protein howev dti identif process often requir expens time consum task includ biolog experi involv larg number candid compound thus varieti comput approach develop mani approach avail chemo genom featur base method attract consider attent method comput featur descriptor drug protein input data train machin deep learn model enabl accur predict unknown dtis addit attent base learn method propos identifi interpret dti mechan howev improv need enhanc predict perform dti mechan elucid address problem develop attent base method design interpret cross attent network ican predict dtis use simplifi molecular input line entri system drug amino acid sequenc target protein optim attent mechan architectur explor cross attent self attent attent layer depth select context matrix attent mechan found plain attent mechan decod drug relat protein context featur without protein relat drug context featur effect achiev high perform ican outperform state art method sever metric davi dataset first reveal statist signific weight site cross attent weight matrix repres experiment bind site thus demonstr high interpret result program freeli avail https githubcomkuratahiroyukiican
|
D011506;D055808
|
T062;T123;T116
|
36,279,283
|
agmk cell model neoplasia evolut dna copi number aberr mirna express transit normal metastat cancer cell studi neoplasia tissu cultur cell line repres evolut normal cell tumor cell need produc cell develop agmk cell line establish cell bank passag interv character biolog properti examin evolut chromosom dna copi number aberr mirna express cell line passag acquisit tumorigen phenotyp passag demonstr use human microarray platform dna copi number profil agmk cell use knowledg synteni recod data human chromosom coordin african green monkey approach reveal accumul dna copi number gain loss agmk cell passag passag span period neoplast transform occur alter occur sequenc gene regul dna copi number imbal sever gene regul endotheli cell angiogenesi surviv migrat prolifer regard mirna express mirna regul passag level appear biolog relev ie log fold chang q passag number updown regul mirna fell number increas passag princip compon analysi group mirna cluster mirna sub cluster group could correl initi promot progress stage describ neoplast develop thirti four agmk mirna associ stage human cancer base data propos evolut agmk cell repres detail model neoplasia vitro
|
D035683;D009369;D016609
|
T123;T191;T114
|
36,279,282
|
explor multipl electr layer over coal seam use transient electromagnet method transient electromagnet method tem wide appli coal hydrogeolog explor owe sensit low resist bodi howev coal seam buri deep particular multipl electr layer vertic direct over stratum result calcul use late channel empir formula tem may longer reflect actual situat studi evalu principl one dimension occam algorithm step perform invers propos various two three four layer electr model invers use occam algorithm result consist electr distribut model thus indic effect algorithm test project larg depth transient electromagnet explor datong coalfield shanxi china select experiment verif occam invers use success identifi various electr strata over coal seam
|
D003031;D003032
|
T090;T121;T167;T109
|
36,279,281
|
cohesin requir meiotic spindl assembl independ role cohes c elegan accur chromosom segreg requir cohesin mediat physic attach chromosom segreg apart bipolar spindl microtubul plus end eman exact two pole toward pair chromosom ask whether strike bipolar structur c elegan meiotic chromosom requir bipolar acentriolar femal meiotic spindl time laps imag mutant lack cohes chromosom spo rec coh coh quadrupl mutant spo rec doubl mutant enter phase separ sister chromatid lack cohes howev quadrupl mutant form apolar spindl wherea doubl mutant form bipolar spindl segreg chromatid two rough equal mass residu non cohes coh depend cohesin separ sister chromatid doubl mutant suffici recruit haspin depend aurora b kinas mediat bipolar spindl assembl appar absenc chromosom bipolar hypothes cohesin depend aurora b might activ inhibit spindl assembl factor manner would affect local chromosom found chromosom local pattern klp cls correl aurora b load chromosom result demonstr cohesin essenti spindl assembl chromosom segreg independ role sister chromatid cohes
|
D017173;D002868
|
T123;T116;T204
|
36,279,280
|
gut microbi metabol capac microbiom human vs wild type rodent reveal like dual role intestin bacteria hepato intestin schistosomiasi increas evid show host gut microbiota might involv immunolog cascad culmin format tissu granuloma under pathophysiolog hepato intestin schistosomiasi studi investig impact schistosoma mansoni infect gut microbi composit function potenti wild type microbiom human mice spite substanti differ microbiom composit baselin select pathway consist affect parasit infect gut microbiom infect mice line display amongst featur enhanc capac tryptophan butyr product might link activ mechan aim prevent excess injuri caus migrat parasit egg complement data previous studi find suggest host gut microbiom might play dual role pathophysiolog schistosomiasi intestin bacteria may contribut egg associ patholog turn protect host uncontrol tissu damag
|
D012555;D000069196;D064307;D012552
|
T032;T007;T028;T047;T001
|
36,279,279
|
novel method estim instantan overal covid case fatal risk among care home resid england covid pandem high mortal rate elder frail worldwid particular care home driven difficulti isol care home wider communiti larg popul size within care facil relat typic household agefrailti resid quantifi mortal risk pose diseas case fatal risk cfr import tool quantifi proport case result death throughout pandem cfr amongst care home resid england monitor close estim cfr appli novel exist method data death care home collect public health england care qualiti commiss compar differ method evalu relat strength weak use method estim tempor trend instantan cfr daili week resolut overal cfr across whole england dis aggreg region level also investig cfr vari base age type care requir dis aggreg whether care home includ nurs staff age resid work contribut summari measur use monitor uk epidem
|
D000086382
|
T047;T067
|
36,279,278
|
cask farp local two class post synapt ach receptor therebi promot cholinerg transmiss chang neurotransmitt receptor abund post synapt element play pivot role regul synapt strength reason signific interest identifi character scaffold requir receptor local differ synaps analyz role two c elegan post synapt scaffold protein lin cask frm farp cholinerg neuromuscular junction constitut knockout muscl specif inactiv lin frm dramat reduc spontan evok post synapt current synapt defect result decreas abund two class post synapt ionotrop acetylcholin receptor acr chrna levamisol activ achr lin achr scaffold function mediat sh pdz domain interact achr frm farp respect thus find show post synapt lin frm complex promot cholinerg synapt transmiss recruit achr post synapt element
|
D017173;D029742
|
T116;T204
|
36,279,277
|
physio biochem analysi molecular character induc lentil mutant line len culinari proteinac food crop consum worldwid protein requir mutat breed use improv protein content yield relat trait well select high desir mutant econom signific investig genotyp variat lentil germplasm carri use induc mutagenesi caffein ethyl methan sulfon em lead nitrat cadmium nitrat mutagen result mutant line generat present studi analyz genet divers lentil mutant line use sodium dodecyl sulfat polyacrylamid gel electrophoresi random amplifi polymorph dna marker rapd heterozygos rapd marker per primer rang averag genet diverg analysi perform use hierarch cluster upgma exhibit mutant line classifi main five subpopul cluster close resembl highest genet coeffici similar observ control mutant h mutant e mutant q j diverg mutant n mutant b mutant r mutant jwith least genet coeffici similar protein miner content fe zn cu increas signific high yield mutant line concern control plant show polymorph variat polypeptid chain term band pattern stomat morpholog high yield mutant perceiv util scan electron microscopi sem exhibit variat stomat size stomat open number stomata present studi promis mutant line biolog physiolog molecular profil provid foundat forthcom preserv consumpt strategi broaden genet divers breed popul lentil
|
D027806
|
T168;T002
|
36,279,276
|
pathobiolog dysbiosi respiratori intestin microbiota month old golden syrian hamster infect sar cov pandem sever acut respiratori syndrom coronavirus sar affect geriatr popul among research model golden syrian hamster gsh one repres studi sar pathogenesi host respons howev anim studi recapitul effect sar human geriatr popul lack address gap inocul month old gsh prototyp ancestr strain sar studi effect virus pathogenesi virus shed respiratori gastrointestin microbiom chang sar infect led high vrna load nasal turbin nt lung trachea well higher pulmonari lesion score later infect dysbiosi throughout sar diseas progress observ pulmonari microbi dynam enrich opportunist pathogen haemophilus fusobacterium streptococcus campylobact johnsonella microb associ inflamm prevotella chang gut microbi communiti also reflect increas multipl genera previous associ intestin inflamm diseas helicobact mucispirillum streptococcus unclassifi erysipelotrichacea spirochaetacea influenza virus fluav pre exposur result slight pronounc patholog nt lung earli dpc notabl chang lung compar gut microbiom dynam similar among age gsh microbiom critic ill covid patient particular lower respiratori tract suggest gshs repres model investig microbi chang sar infect relationship residenti microbiom confound factor sar infect wide use anim model contribut better understand complex associ host respons viral infect
|
D000069196;D000086382
|
T067;T047;T007;T001
|
36,279,275
|
uniqu estim eeg analysi order ica independ compon analysi ica method solv blind sourc separ problem ica need weak assumpt estim unknown sourc observ signal suitabl electroencephalographi eeg analysi serious disadvantag tradit ica algorithm result often fluctuat converg uniqu global optim solut run mani local optima permut ambigu recent propos new ica algorithm name order ica simpl extens fast ica order ica theoret guarante extract independ compon uniqu order avoid local optima practic paper investig use order ica eeg analysi experi show order ica could give uniqu solut signal larg non gaussian eas parallel could reduc comput time
|
D012815;D004569
|
T060;T034;T066
|
36,279,274
|
engin indel substitut variant divers ancient enzym use graphic represent ancestr sequenc predict grasp ancestr sequenc reconstruct techniqu gain widespread use molecular evolut studi protein engin accur reconstruct requir abil handl appropri larg number sequenc well insert delet indel event avail approach exhibit limit address limit develop graphic represent ancestr sequenc predict grasp effici implement maximum likelihood method enabl infer ancestor famili member grasp implement partial order graph pog repres infer insert delet event across ancestor enabl identif build block protein engin valid capac engin novel protein realist data predict ancestor sequenc across three distinct enzym famili glucos methanol cholin gmc oxidoreductas cytochrom p dihydroxysugar acid dehydratas dhad test ancestor demonstr enzymat activ studi demonstr abil grasp support larg data set sequenc employ insert delet identifi build block engin biolog activ ancestor explor variat evolutionari time
|
D019143;D054643
|
T045;T038
|
36,279,273
|
competit analysi onlin revenu manag two hierarch resourc multipl fare class resourc alloc problem one key issu field revenu manag tradit model usual reli restrict assumpt demand inform arriv process sometim line realiti overcom shortcom method competit analysi onlin algorithm elimin need assumpt demand arriv adopt deal quantiti base revenu manag problem current model paper consid two downgrad compat level resourc given capac fare level resourc object accept appropri custom assign appropri resourc maxim revenu compar exist literatur paper general concern resourc alloc problem consid multipl fare level resourc perspect onlin algorithm competit analysi upper bound optim onlin strategi deriv paper
|
D000465;D040841
|
T081;T170
|
36,279,272
|
grief reaction depress anxieti cope relat palliat patient death thailand grief normal psycholog respons relat loss love one shown associ psycholog reaction like depress anxieti signific stress mani relat cope thailand limit research studi grief especi palliat set studi aim examin grief reaction depress anxieti cope relat palliat patient death
|
D003863;D006117
|
T184;T041;T048
|
36,279,270
|
hsv influenza infect induc linear circular splice long neat isoform herp simplex virus hsv virion host shut vhs protein cleav cellular viral mrnas translat initi depend mechan spare circular rnas circrna show vhs mediat degrad linear mrnas lead enrich circrna relat linear mrnas hsv infect also observ influenza virus iav infect like due degrad linear host mrnas mediat iav pa x protein cap snatch rna depend rna polymeras circrna enrich due increas circrna synthesi due general loss linear rnas contrast biogenesi circrna origin long isoform neat nuclear paraspeckl assembl transcript neat induc hsv infect vhs independ manner iav infect associ induct novel linear splice neat within downstream circrna neat form scaffold paraspeckl nuclear bodi locat interchromatin space must like remain unsplic paraspeckl assembl regul hsv iav infect show neat splice regul induc ectop co express hsv immedi earli protein icp icp potenti link increas express splice neat identifi condit neat splice perform larg scale screen publish rna seq data uncov induct neat splice poli read similar hsv iav infect cancer cell upon inhibit knockdown cdk med subunit mediat complex phosphoryl cdk summari studi reveal induct novel circular linear neat splice isoform common characterist hsv iav infect highlight potenti role cdk hsv iav infect
|
D018259;D017874;D007251;D006561
|
T123;T005;T116;T047
|
36,279,269
|
develop preoper questionnair improv satisfact hallux valgus repair delphi studi satisfact hallux valgus repair often poor despit good surgic outcom mani tool develop assess outcom procedur howev none evalu associ initi motiv repair reason post surgic dissatisfact aim studi develop new tool analys subject object expect individu pre oper consult hallux valgus repair order improv post surgic satisfact
|
D006215
|
T190
|
36,279,265
|
tlr control myeloid deriv suppressor cell expans function lung cbl mice infect schistosoma japonicum toll like receptor tlrs play import role induct innat adapt immun respons schistosoma japonicum japonicum infect howev role toll like receptor tlr mous lung japonicum infect myeloid deriv suppressor cell mdscs affect absenc tlr clear understood studi result indic mdscs accumul proport activ cd cd cell decreas lung mice week japonicum infect express tlr detect isol pulmonari mdscs result show express tlr mdscs increas infect furthermor tlr agonist r could regul induct effect solubl egg antigen sea pulmonari mdscs vitro meanwhil tlr defici could promot pulmonari mdscs expans function regul express pd l secret il mice infect japonicum mechanist studi reveal japonicum infect antigen effect mediat nf b signal moreov tlr defici aggrav japonicum infect induc damag lung inflammatori cell infiltr interstiti dilat granuloma tissu summari studi indic tlr signal inhibit accumul function mdscs japonicum infect mous lung regul express pd l secret il via nf b signal
|
D000072737;D012554;D051199
|
T129;T116;T025;T192;T047
|
36,279,262
|
agoni mystic practic susuk case report background charm needl otherwis known susuk needl shape pin insert subcutan various bodi part common insert shaman orofaci region grant magic power wearer health wealth beauti benefit talisman preval among women south east asia countri case report year old woman present recurr musculoskelet symptom multipl site physic assess reveal mild tender right hip joint plain pelvic radiograph show incident find susuk around genit region older skull pelvic radiograph display similar find patient susuk insert year ago marriag stabil beauti incident discoveri patient repeat visit clinic request imag determin whether susuk still present shaman attempt mystic remov also develop persist preoccup worri guilt relat susuk presenc refer psychiatri assess diagnos general anxieti disord start psychotherapi pharmacolog treatment simultan spiritu therapi conclus case report describ link susuk implant psycholog ill even though report specif correl susuk general anxieti disord establish guilt shame strong relationship anxieti
|
D005547
|
T020;T037;T072
|
36,279,260
|
evalu dri eye symptom risk factor among medic student serbia dri eye multifactori diseas defin less year ago relat common disord affect number well known risk factor dri eye challeng diagnos possibl discrep patient symptom clinic sign overlap ocular surfac diseas literatur wise dri eye usual associ age therefor investig within older popul recent studi focus young adult student popul demonstr higher preval dri eye previous expect
|
D013337;D015352;D006967
|
T184;T047;T046;T097
|
36,279,259
|
influenc asp isomer trypsin trypsin like proteolysi long live protein llps although less common short live counterpart increas recogn play import role age relat diseas alzheim particular spontan chemic modif accru time serv indic contributor disrupt autophagi exampl isomer llps common occur absenc protein turnov simultan interf protein turnov imped proteolysi addit biolog implic creat isomer may also interfer analysi clarifi bottom proteom experi reli protein digest proteas common trypsin extent isomer might interfer trypsin digest unknown use combin liquid chromatographi mass spectrometri examin effect isomer proteolysi trypsin chymotrypsin isomer aspart acid serin residu repres common site isomer llps place various locat relat prefer proteas cleavag point evalu influenc digest effici trypsin found relat toler isomer except present residu immedi c termin arg chymotrypsin influenc isomer digest less predict result long rang interfer isomerpeptid combin given trypsin chymotrypsin like behavior proteasom establish biolog relev isomer llps substrat isomer site also test proteasom degrad signific disrupt proteolysi observ suggest llps persist long enough isomer difficult cell digest
|
D002918;D011506
|
T123;T121;T126;T116
|
36,279,257
|
character transient protein protein interact trp cys quench comput simul transient protein protein interact occur frequent crowd condit encount biolog environ tryptophan cystein quench introduc experiment approach minim label character interact protein due sensit nano microsecond dynam subnanomet length scale experi pair comput model differ resolut includ fulli atomist molecular dynam simul interpret experiment observ gain molecular level insight approach appli model system villin variant drkn sh domain presenc protein g crowder demonstr trp cys quench experi differenti overal attract repuls interact differ protein discern variat interact prefer differ protein surfac locat close integr experi simul also provid opportun evalu differ molecular forc field simul concentr protein solut
|
D003545;D056004
|
T123;T121;T116;T066;T044
|
36,279,255
|
periodont chang follow distract osteogenesi patient cleft lip palat clinic trial evalu inflammatori mediat level periodont chang follow distract osteogenesi patient cleft lip palat clp use mid maxillari distract mmd
|
D002971;D002972;D019857
|
T061;T019
|
36,279,246
|
case year old boy present asthenia low back pain abdomin distent onset symptom slow progress month patient contribut past medic histori physic examin vital sign normal pallor posit fluid wave test result note lower limb edema mucocutan lesion palpabl lymph node enlarg laboratori work reveal decreas hemoglobin concentr gdl normal rang gdl decreas hematocrit level normal rang laboratori valu normal contrast enhanc ct chest abdomen pelvi perform fig
|
D010808;D006454
|
T060;T123;T058;T116
|
36,279,245
|
case heterotop pancrea jejun mesenteri year old woman present emerg depart acut worsen prolong unexplain nausea nonbili vomit mild upper abdomin pain year durat bowel habit regular histori diarrhea fresh alter blood stool inquiri histori facial flush excess diaphoresi asthmalik symptom histori unrev particular histori known malign clinic examin vital sign stabl abdomen soft focal tender palpabl mass routin blood investig includ complet blood count liver kidney thyroid function test yield result within normal limit hydroxyindoleacet acid chromogranin level elev initi evalu contrast enhanc ct abdomen pelvi perform subsequ indium octreotid scan perform recommend radiologist month ct
|
D007204;D015282
|
T125;T121;T196;T116
|
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