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biomedical-topic-categorization-validation

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36,274,477
studi dose profil ct fluoroscopi work aim contribut descript dose profil comput tomographi fluoroscopi ctf approach use function model fit singl slice dose profil ssdp point insid gantri ct unit special attent point rotat axi function model success test measur perform use gafchrom film paramet ssdp rotat axi isocent cm cm isocent determin model allow estim slice thick isocent point cm cm isocent differ slice thick result overestim comput tomographi dose index ctdi valu high nomin slice thick instead model estim valu use result obtain work provid good descript dose profil use studi comparison measur perform phantom patient
D014057
T060
36,274,476
comparison studi geant mcnp neutron induc gamma simul neutron induc gamma simul multipl applic various field radiat therapi imag nuclear well log among mont carlo code mcnp geant suitabl solut nuclear detect sinc publish comparison geant mcnp especi simul neutron induc gamma spectra therefor aim paper compar geant mcnp simul low energi less mev neutron induc inelast captur gamma spectra feasibl could help provid altern approach research mcnp avail two repres model pertain nuclear well log applic design employ purpos comparison base neutron induc inelast captur gamma spectra analyz use differ method associ code specif time window energi cutoff physic track base cross section librari endfb vii result obtain mcnp geant match well demonstr feasibl use either code applic
D009502
T167
36,274,473
preval demograph clinic featur neuroimag inter ethnic differ mogad malaysia global perspect cns iidd test posit anti mog known distinct clinic profil better overal prognosi
D009471
T047
36,274,447
spatio tempor segment imag sequenc non invas analysi cardiovascular structur function whitefish embryo label free quantit analysi cardiovascular structur function wild fish high import still unsolv problem develop robust algorithm bright field microscopi data process allow reliabl detect quantif circulatori system across whole anim verifi techniqu vivo experi broad whitefish coregonus nasus embryo calcul morphofunct featur heart vessel quit specif due low temperatur embryon develop fish correspond well refer data obtain ex vivo techniqu research highlight feasibl non invas cardiovascular imag measur valuabl behavior environment toxicolog drug discoveri mani studi
D012487;D002319
T022;T013
36,274,423
preval seizur brain tumor meta analysi preval seizur brain tumor vari substanti studi even similar histopatholog type aim identifi seizur preval commonest type brain tumor
D018303;D009837;D001932;D001254
T191
36,274,387
substitut phenethylamin base lactam deriv antimicrobi anticanc lactamas inhibitori properti studi seri novel lactam deriv synthes yield rang antimicrobi activ investig bacteri fungal isol caus nosocomi infect result reveal novel lactam deriv especi compound show antibacteri activ rang gml contrast compound show antifung activ fungal isol follow biochem nitrocefin investig compound antibacteri activ carri well effect lactamas enzym accord result compound inhibit lactamas enzym bacteri isol furthermor anticanc activ toxic profil lactam deriv also studi colorect cancer caco common type cancer non human dermal fibroblast cell line result reveal compound shown best anticanc activ lowest toxic profil among compound therefor compound especi compound could use treatment colorect cancer relat nosocomi infect furthermor potenti antibiot put forward investig resist mechan pharmacolog studi
D003428;D015179
T047;T191
36,274,386
recent advanc transit metal catalyz reaction chloroquinoxalin applic bioorgan chemistri import quinoxalin framework exemplifi presenc well known drug vareniclin brimonidin quinacillin etc past year prepar varieti organ compound contain quinoxalin framework report sever research group chloroquinoxalin success use substrat mani synthet approach due easi avail along reactiv especi toward divers rang metal transit metal catalyz transform includ sonogashira suzuki heck type cross coupl reaction transit metal eg pd cu fe nb catalyst play key role transform construct various cx eg cc cn co cs cp cse etc bond approach classifi base catalyst employ type reaction perform natur cx bond format reaction sever result quinoxalin deriv shown divers biolog activ includ apoptosi induc activ sirt inhibit inhibit luciferac enzym antibacteri antifung activ cytotox toward cancer cell inhibit pde phosphodiesteras potenti use covid etc notabl review articl cover literatur base transit metal catalyz reaction chloroquinoxalin time summar relev biolog activ result product rather uncommon therefor attempt made current review articl summar recent advanc note transit metal catalyz reaction chloroquinoxalin ii relev mechanist discuss iii along vitro silico biolog studi wherev report iv includ structur activ relationship sar within particular seri product report
D000086382
T047;T067
36,274,385
antibacteri mechan star anis essenti oil microcapsul encapsul rice protein depolymer pectin electrostat complex applic crab meatbal mix solid matrix depolymer pectin dp rice protein rp investig improv antibacteri activ star anis essenti oil saeo microencapsul encapsul undertaken via electrostat complex method follow spray dri optim condit saeo microcapsul encapsul effici acquir dp rp dp saeo ph dp rpsaeo microcapsul exhibit spheric shape particl smaller particl size sustain releas ftir morpholog analysi confirm saeo success encapsul solid matrix microcapsul dp rpsaeo microcapsul caus destruct cytomembran reduct membran protein led alter cell membran fluiditi integr meanwhil dp rpsaeo microcapsul repress key enzym tricarboxyl acid tca hexos monophosph pathway hmp cycl pathway e coli aureus applic experi indic dp rpsaeo microcapsul effect control growth e coli aureus crab meatbal
D029523;D012275;D003386;D009822
T168;T204;T002;T109
36,274,384
parameter asymmetr model fungal spore germin asymmetr model dantigni et al new model germin fungi intern journal food microbiolog capabl fit symmetr asymmetr curv fungal spore germin howev shape paramet asymmetr model must deriv regress model experiment data fungal spore germin thus asymmetr model fit spore germin test condit paper solv limit previous propos shape paramet base asymmetr model replac use pure biolog paramet base asymmetr model formula see text p percentag germin spore time p max maximum percentag germin spore germin time time p p max slope fungal spore germin repres rate fungal spore germin modifi asymmetr model valid germin data six fungal speci collect literatur result show modifi asymmetr model describ spore germin fungi studi well moreov modifi asymmetr model various environment condit estim proper via cardin model inflect solv limit previous asymmetr model conclud modifi asymmetr model improv previous asymmetr model predict fungal spore germin
D008954;D013171
T007;T075
36,274,359
hydroxyapatit nanoparticl cell interact new approach disclos fate membran bound internalis nanoparticl hydroxyapatit nanoparticl popular tool bone regener also use gene deliveri anticanc drug understand mechan action particular latter applic crucial predict toxic end aim elucid import nanoparticl membran interact cytotox mg cell use two differ type nanoparticl addit convent techniqu studi nanoparticl internalis evalu compar newer less exploit approach hydroxyapatit magnesium dope hydroxyapatit nanoparticl use suspens compact specular disc comparison cell seed disc supplement nanoparticl allow direct interact cell membran materi rule main mechan toxic addit standard techniqu flow cytometri inconclus use assess nanoparticl toxic interest use intracellular calcium fluoresc probe reveal presenc high number calcium rich vesicl nanoparticl supplement cell cultur structur could detect transmiss electron microscopi due liquid content howev use cryo soft x ray imag use visualis cellular ultrastructur without treatment vitrif quantifi linear absorpt coeffici organell possibl identifi multivesicular bodi potenti act calcium store studi advanc state degrad hydroxyapatit magnesium dope hydroxyapatit nanoparticl within mg cell observ overal demonstr combin fluoresc calcium probe togeth cryo sxt excel approach investig intracellular calcium especi found solubl form
D017886;D053758
T121;T122;T073;T197
36,274,355
influenc deep subtrop reservoir karstic riverin carbon cycl regulatori factor insight season hydrolog chang reservoir wide establish worldwid consider environment impact especi riverin carbon cycl howev influenc reservoir cycl differ form carbon regul factor eg season variat versus hydrolog manag simultan studi fill knowledg gap season water sampl deep subtrop reservoir longtan reservoir pearl river collect concentr stabl carbon isotop dissolv inorgan carbon dic dissolv organ carbon doc particul organ carbon poc determin variat stabl carbon isotop dic doc poc river reservoir system indic activ product degrad process differ layer estim dic doc poc intercept degrad within reservoir result illustr hydrolog manag water storag regul season variat differ perspect control cycl differ form carbon reservoir addit gradual increas number reservoir hydrolog manag consid potenti effect strategi adjust carbon biogeochem cycl reservoir futur
D004784;D045483
T070;T057
36,274,354
role ammonia oxid microorgan remov organ micropollut simul riverbank filtrat biodegrad play import role remov organ micropollut omp riverbank filtrat rbf drink water product abil ammonia oxid microorgan aom remov omp attract increas attent howev distribut aom rbf role degrad omp remain unknown studi behavior select omp distribut aom role degrad omp rbf explor column batch experi simul first meter riverbank result show select omp effect remov omp remov primarili biodegrad part adsorpt ineffici remov omp tend low molecular weight low log p contain secondari amid secondari sulfonamid secondari ketimin benzyl term microbi communiti relat abund aom increas inlet sand outlet sand domin ammonia oxid archaea whose relat abund increas inlet sand outlet sand comammox account inlet sand outlet sand abund aom amoa gene kept stabl inlet sand control column decreas treatment column suggest inhibit effect allylthiourea atu aom observ aom play import role degrad omp inhibit led correspond inhibit omp complet suppress particular omp low molecular weight contain primari amid secondari amid benzyl secondari sulfonamid like remov aom studi reveal vital role aom remov omp deepen understand degrad omp rbf offer valuabl insight physiochem properti omp aom co metabol potenti
D014874;D018508
T131;T052;T057
36,274,353
hydrochem evolut characterist genesi groundwat long term infiltr reclaim water chaobai river beij reus reclaim water rw river ecolog restor global water shortag region inevit brought potenti risk groundwat howev littl known effect reclaim water hydrochem evolut groundwat especi long term infiltr condit herein year monitor data reclaim water groundwat adopt analyz characterist genesi groundwat hydrochem evolut long term infiltr reclaim water jian river chaobai river beij result show hydrochem compon groundwat total perform signific increas na cl k decreas ca mg hco concentr long term infiltr reclaim water meanwhil signific hydrochem evolut differ groundwat jian river chaobai river observ jian river hydrochem type groundwat shift gradual hco camg type hco cl naca approach reclaim water contrast hydrochem evolut chaobai river show obvious opposit trend hco camg hco cl namg final deviat reclaim water type clhco na phreeqc simul indic differ hydrochem evolut mediat synerg sediment thick geochem process eg mix sulfat reduct mediat thinner sediment strong mix jian river confirm genesi groundwat hydrochem evolut progress approach reclaim water differ jian river multipl regress analys reveal genesi groundwat hydrochem evolut chaobai river divid two stage accord increas sediment thick reclaim water qualiti infiltr amount lead propos caus initi stage due thinner sediment format contribut within confid interv respect subsequ rise sediment thick prove play crucial role groundwat hydrochem evolut trend away reclaim water contribut within confid interv main attribut reduc reclaim water infiltr rate favor sulfat reduct condit find advanc understand groundwat hydrochem evolut long term infiltr reclaim water also guid futur predict evolut trend
D014874;D060587
T081;T131;T070;T082
36,274,352
p model periop psycholog prepar pre surgic pre medic procedur psycholog prepar psychophysiolog intervent appli psychophysiolog psycholog intervent support success post surgic outcom among patient undergo surgic medic procedur howev translat research need extend current understand practic evid base evid inform behavior intervent improv outcom surgic medic procedur healthcar becom increas integr biopsychosoci orient practition eg health psychologist neuropsychologist pain psychologist psychiatrist nurs play integr role surgic intervent profession eg neurosurgeon bariatr surgeon anesthesiologist transplant surgeon interventionalist radiologist role includ pre surgic evalu identifi pre emptiv concern implement behavior intervent ultim act improv outcom surgeri medic procedur paper author review status broader practic periop behavior intervent review pre surgic pre procedur behavior risk factor translat psychophysiolog behavior intervent optim post surgic post procedur outcom provid general framework p model use periop practic carri pre surgic pre procedur behavior intervent specif role behavior biofeedback intervent prepar patient undergo surgeri medic procedur detail psycholog prepar address pre surgic pre medic procedur behavior risk factor help periop healthcar provid patient maxim post oper success
D010146;D006282
T184;T097
36,274,351
rapid uhplc qda method quantif human salivari amino acid profil abnorm salivari amino acid aa level may indic dysfunct bodi noninvas sampl easili cost effect saliva rapid precis simpl analysi method becom import quantit salivari aa profil one step precipit protein result extract deriv aminoquinolyl n hydroxysuccinimidyl carbam aqc within min quantit aa profil achiev within min singl run ultra high perform liquid chromatographi coupl singl quadrupol mass spectrometri uhplc qda detector method valid accept accuraci rang appropri linear coeffici r good intra inter day precis repeat stabil rsd recoveri three differ spike concentr rang matrix effect simpl rapid robust method success appli quantifi human salivari amino acid level taurin aminobutyr acid methionin tryptophan healthi peopl close loq besid level histidin cystin abl measur due relat high loq consid limit develop method
D000596;D013654
T123;T121;T116
36,274,333
character lncrnas mycorrhiz tomato elucid role lncrna diseas resist long noncod rnas lncrnas attract widespread attent meaning role various plant biolog process howev potenti function lncrnas plant benefici microorgan interact fulli explor arbuscular mycorrhiza symbiosi accompani system induct defens respons host leav present studi global profil lncrna express explor potenti regulatori role fungi inocul tomato leav among differenti express lncrnas novel lncrna lncrna signific downregul leav fungi inocul tomato affect tomato resist pathogen infect one compet endogen rna network lncrna sli mirc verifi use coexpress system silenc lncrna overexpress sli mirc enhanc tomato resist phytophthora infestan wherea overexpress lncrna decreas reactiv oxygen speci scaveng specul lncrna may involv mycorrhiza induc defens respons find broaden knowledg potenti regulatori role ncrnas symbiosi
D018551;D062085;D038821
T123;T168;T004;T114;T002
36,274,289
model respons urban lichen broad scale chang air pollut climat creat resili citi import understand effect global chang driver citi biodivers base ecolog indic ei use biodivers basi ecosystem structur composit function previous studi lichen use ei monitor effect global chang driver urban context singl citi studi thus current understand lichen affect driver work broader scale therefor aim quantifi varianc lichen biodivers base metric taxonom trait base explain environment driver work broad spatial scale urban context local driver superimpos end perform unpreced effort sampl epiphyt lichen green space across continent gradient portug estonia twenti six broad scale driver retriev includ air pollut bio climat variabl dimension reduc mean princip compon analysi pca thirti eight lichen metric model score first two axe pca varianc partit pollut climat compon first time determin metric varianc explain broad scale driver broad scale air pollut show import climat across major metric taxonom metric better explain air pollut expect climat surpass air pollut trait base metric group consequ metric varianc shown occur local scale suggest work necessari deciph effect climat chang furthermor although driver work within citi prevail spatial scale must consid simultan use lichen ei citi continent global scale
D008011;D000397;D000393
T131;T069;T002;T080
36,274,265
helic structur cyclic peptid effect n methyl amid versus ester alpha helic turn reproduc cyclic pentapeptid first fifth amino acid sidechain correct join structur studi cd nmr silico reveal n methyl posit involv hydrogen bond disrupt helic wherea ester bond maintain helic promot greater cell uptak
D000577;D010456
T116;T109
36,274,257
role transepitheli electr resist mechan retin pigment epitheli barrier retin disord transepithelialtransendotheli electr resist teer wide accept quantit techniqu measur integr tight junction dynam cell cultur model endotheli epitheli monolay valu teer reflect physic structur characterist epithelialendotheli cell teer valu prefer physiolog indic reflect transport rate ion macromolecul paracellular pathway use evalu permeabl paracellular pathway teer valu high specif permeabl reactiv tight connect complex teer valu effect indic evalu integr cell barrier cell barrier control diffus penetr various substanc adjac intercellular space also regul transport ion macromolecul across one hand cell barrier protect bodi harm substanc hand restrict entri therapeut drug therefor increas permeabl paraepitheli pathway teer valu decreas otherwis increas review articl compar advantag disadvantag exist method measur teer summar factor affect teer accuraci well role teer mechan retin pigment epitheli barrier retin disord prolif vitreoretinopathi pvr age relat macular degener amd diabet retinopathi retin pigmentosa
D012168;D012164
T123;T047;T109
36,274,256
microrna irrit bowel syndrom systemat review irrit bowel syndrom ib common gastrointestin disord report contribut abdomin pain decreas qualiti life work product affect individu lead cachexia frailti howev molecul regul irrit bowel syndrom fulli clarifi microrna mirna small non code rnas inhibit translat target messeng rnas previous studi shown mirna critic role regul pathogen irrit bowel syndrom therefor systemat review focus mirna regul irrit bowel syndrom pubm web scienc search retriev refer list elig articl relat review origin articl review report util mirna potenti biomark target specif therapi ib publish english includ among identifi studi elig studi includ systemat review result suggest mirna potenti biomark target gene therapi ib studi includ clinic studi necessari confirm util mirna biomark target gene therapi ib
D043183;D035683
T123;T047;T114
36,274,249
compar metabolom analysi pericarp four varieti zanthoxylum bungeanum maxim qualit quantit analysi metabolit perform metabolom compar pericarp four varieti zanthoxylum bungeanum maxim zanthoxylum bunganum scion combin three rootstock varieti zanthoxylum piasezkii maxim yj juli zanthoxylum bunganum maxim qj august zanthoxylum bunganum maxim bj time zanthoxylum bungeanum seedl breed compar control mj total metabolit identifi zanthoxylum bungeanum maxim pericarp base chromatographi mass spectrometri dual detect platform metabolit four varieti z bungeanum vari identifi regul regul differenti metabolit mj bj mj qj mj yj qj bj yj bj yj qj meanwhil differenti metabolit composit distinct among various varieti z bungeanum domin phenol compound flavonoid phenol acid especi highest varieti juli zanthoxylum bunganum maxim highlight compar metabolom analyz four varieti zanthoxylum bungeanum pericarptot metabolit identifi main flavonoid phenol acidjuli august zanthoxylum bunganum maxim highest antioxid capacityth rootstock juli zanthoxylum bunganum maxim recommend loess plateau
D032106
T002
36,274,242
acut kidney injuri induc immun checkpoint inhibitor lung cancer patient immun checkpoint inhibitor ici novel immunotherapi drug signific improv outcom varieti cancer includ lung cancer howev ici could induc immun relat advers effect ira character clinic manifest resembl autoimmun disord main type ira kidney acut kidney injuri aki review describ type ici target lung cancer especi approv us food drug administr clinic trial lung cancer patient next summar current understand mechan involv ici induc aki final highlight direct address ici associ aki benefit lung cancer patient clinic
D008175;D064420;D058186
T047;T191;T037;T046
36,274,241
applic quantit flow ratio via dimension coronari angiographi clinic cardiolog review fraction flow reserv ffr gold standard assess hemodynam chang coronari stenosi sever limit high cost requir invas pressur wire advers drug reaction limit wide applic ffr clinic practic contrast quantit flow ratio qfr recent develop method rapid calcul ffr dimension quantit coronari angiographi without use vasodil pressur wire review provid updat summari principl qfr correl qfr ffr current applic qfr clinic cardiolog conclus qfr provid platform function evalu coronari stenos base angiograph data without invas procedur develop optim qfr techniqu expand applic qfr clinic cardiolog rang diagnosi coronari intervent cardiac surgeri benefit patient
D053805;D023921;D002309
T201;T047;T091
36,274,240
metabol bariatr surgeri treatment obes complic hypertens mechanist insight increas dietari fat energi suppli ratio led gradual increas obes risk hypertens patient obes much higher normal popul weight loss becom popular method control obes hypertens metabol bariatr surgeri mbs also call weight loss surgeri signific effect weight bodi metabol patient recent studi shown blood pressur obes patient hypertens signific improv mbs therefor review briefli describ relationship obes hypertens summar effect mbs hypertens focus mechan mbs achiev satisfactori efficaci treat hypertens
D050110;D006973
T061;T047
36,274,222
high luminesc mof situ fabric sustain corn starch gel composit fluoro switchabl revers sensor trigger antibiot oxo anion frequent use antibiot growth industri lead pollut sever natur resourc one major consequ fatal human health explor smart sens materi high anticip ultrasensit detect hazard organ robust porous hydrogen bond network encompass free nh moieti zn ii base metal organ framework mof use select detect antibiot toxic oxo anion ppb level framework abl detect electron dissimilar antibiot sulfadiazin nitrofurazon via fluoresc turn turn process respect antibiot trigger revers fluoro switch phenomena fluoresc also observ use fluorimetr method extens theoret investig perform establish fluoro switch respons trigger class antibiot also sens oxo anion investig reveal interchang homo lumo energi level fluorophor analyt respons fluoro switchabl sens activ sensor show versatil detect abil reflect detect carcinogen nitro group contain drug roxarson view sustain environ along quick respons merit situ mof gel composit cs cs corn starch prepar use cs due use potenti featur biocompat toxicolog innocu good flexibl low commerci price mof composit exhibit visual detect analyt well antibiot trigger revers fluoro switchabl colorimetr respons therefor cs repres promis smart sens materi monitor antibiot oxo anion particular appropri real field analysi carcinogen drug molecul roxarson food specimen
D000073396;D012406;D000080745
T121;T073;T109
36,274,219
year old woman remot histori breast cancer present low back pain chiropract clinic hong kong imag find consist vertebr hemangioma vertebr metastat lesion background patient common visit chiropract clinic treatment low back pain often due injuri degen spinal condit rare serious under patholog may identifi report describ year old woman remot histori breast cancer present low back pain chiropract clinic hong kong imag find consist vertebr hemangioma vertebr metastat lesion case report year old woman histori breast cancer status chemotherapi mastectomi year prior present chiropractor acut exacerb chronic low back pain lower extrem paresthesia previous visit general practition underw radiographi support diagnos degen lumbar spondylosi hemangioma fifth lumbar vertebra given patient worsen status previous cancer chiropractor order lumbar magnet reson imag initi visit consist multilevel spinal metastasi chiropractor refer patient oncologist perform positron emiss tomographycomput tomographi suggest breast cancer recurr metastasi greatest hypermetabol activ evid within level suspect vertebr hemangioma suggest find initi appear innocu plain radiographi contain under metastasi conclus case illustr patient fail respond treatment low back pain clinic referr undertaken investig identifi possibl serious under patholog
D017116;D001943;D013125;D002684;D006391
T184;T047;T191;T091
36,274,217
effect antilog platelet rich plasma revascular rabbit prefabr flap background aim investig effect local applic autolog platelet rich plasma prp angiogenesi rabbit prefabr flap materi method femor arterioven bundl prefabr flap construct side abdomen new zealand white rabbit random divid experiment side control side side total autolog prp inject around prefabr femor vascular bundl experiment side amount salin inject control side day stage ii surgeri perform lift island flap implant femor vascular bundl tip preconfigur flap marker line sutur situ twenti rabbit divid equal group group day stage surgeri group b day stage surgeri group c day stage ii surgeri group day stage ii surgeri surviv neovascular flap group compar microscop observ histolog immunohistochemistri result densiti neovascular much higher experiment side control side group statist signific increas time p seven day stage ii surgeri flap surviv better experiment side control side conclus prp effect promot revascular prefabr flap vascular densiti increas time
D053657;D013524
T023;T031
36,274,210
nanoclay modul cation occup manganes ferrit catalyt antibacteri treatment control prepar current frontier field inorgan nanomateri base artifici enzym nanozym ferrit factor affect cation occup complex make modul cation occup extrem challeng herein report new strategi modul cation occup manganes ferrit mfo base structur properti nanoclay ie montmorillonit k demonstr montmorillonit k main chang valenc state occup manganes ion manganes ferrit iron ion k increas proport mn ii manganes ferrit caus manganes ion migrat tetrahedr site expect prepar new inorgan compound possess excel enzym like catalyt activ antibacteri function properti attribut mn ii acceler fe iii reduct hydroxyl radic format furthermor steadi state kinet assay use studi reaction mechan detail vitro vivo antibacteri experi show synthes inorgan compound exhibit satisfactori disinfect wound skin recoveri effici work emphas control prepar new inorgan compound biomimet activ provid novel insight biolog effect inorgan nanomateri
D008345;D001546
T123;T196;T121;T197
36,274,188
mechan properti degre sclerotis element composit gastric mill red swamp crayfish procambarus clarkii decapoda crustacea gastric mill decapoda uniqu featur compris teeth stabil ossicl particl sort seta involv fragment sort food structur serv interfac organ environ materi properti complement morpholog hold inform function trophic prefer provid basi compar research gastric mill gastric mill compon adult red swamp crayfish procambarus clarkii studi micro structur via scan electron microscopi b element composit energi dispers x ray spectroscopi c heterogen materi properti degre tan autofluoresc confoc laser scan microscopi mechan properti hard elast nanoindent techniqu morpholog micro structur previous describ speci mechan properti autofluoresc studi epicuticl exocuticl could analyz individu materi properti gradient valu decreas interact surfac toward interior could determin final abl relat mechan properti data element composit degre tan found epicuticl teeth among hardest stiffest biolog materi invertebr due incorpor high proport silicon
D003400;D000070559
T023;T204
36,274,185
smartphon assist guid self help cognit behavior therapi young peopl distress voic smartvoic studi protocol random control trial long stand view auditori verbal hallucin avh hear voic sign schizophrenia challeng research demonstr lie continuum rang normal patholog experi relat distress need care hear voic preval adolesc later life hear voic adolesc indic risk sever psychopatholog function impair suicid later life increas evid efficaci cognit behavior therapi voic cbtv adult schizophrenia research psycholog treatment youth distress voic scarc aim current studi examin efficaci cbtv deliv use smartphon base ecolog momentari assess intervent emi transdiagnost sampl youth
D015928;D014831
T061;T040
36,274,183
contact trace reveal communiti transmiss covid new york citi understand sar cov transmiss within among communiti critic tailor public health polici local context howev analysi communiti transmiss challeng due lack high resolut surveil test data use contact trace record case contact new york citi second pandem wave provid detail character oper perform contact trace reconstruct exposur transmiss network individu zip code scale find consider heterogen report close contact secondari infect evid extens transmiss across zip code area analysi reveal spatial pattern sar cov spread communiti tight interconnect exposur transmiss find locat higher vaccin coverag lower number visitor point interest reduc within cross zip code transmiss event highlight potenti measur curtail sar cov spread urban set
D016358;D000086382
T058;T067;T047
36,274,179
pv ire cre mous line target excitatori granul neuron cerebellum parvalbumin express inhibitori neuron pv in critic balanc fine tune complex neuron circuit studi pv biolog requir tool specif label target manipul among creloxp system popular mice two common use pv cre line cite time report mous cerebellar cortex pv cre activ restrict inhibitori neuron imag cre activ report demonstr recombin excitatori granul cell present evid pv cre recombin spatial regul lobul specif detect granul cell extern intern granul cell layer aris strong transient pvalb express progenitor e e delay subset inhibitori interneuron asynchron pv protein express togeth find establish spatio tempor pattern pv cre activ mous cerebellum rais consider condit target pvalb express inhibitori popul
D010320;D007395
T123;T116;T025
36,274,176
efficaci ketogen diet cdkl relat epilepsi singl arm meta analysi drug resist epilepsi one import featur cyclin depend kinas like cdkl defici disord ketogen diet kd may effect patient cdkl relat epilepsi littl high qualiti evid confirm efficaci meta analysi investig efficaci safeti kd cdkl relat epilepsi
D055423;D004827;D000069279
T061;T047;T033
36,274,174
ivabradin toxic case report describ case symptomat bradycardia result ivabradin toxic measur ivabradin level limit report literatur
D001919;D001552
T033;T121;T109
36,274,172
effect rapid fluid infus hemoglobin concentr systemat review meta analysi rapid fluid administr may decreas hemoglobin concentr hb dilut effect could limit increas oxygen deliveri expect posit respons fluid challeng critic ill patient aim quantifi decreas hb rapid fluid administr
D016638;D018805
T047;T046
36,274,170
high resolut transcriptom inform glial patholog human tempor lobe epilepsi pathophysiolog epilepsi under complex network dysfunct neuron glia molecular cell type specif contribut remain poor defin human diseas studi valid method simultan isol neuron neun astrocyt pax neun oligodendrogli progenitor opc olig neun enrich nuclei popul non diseas fresh frozen human neocortex appli character distinct transcriptom popul isol electrod map tempor lobe epilepsi tle surgic sampl nuclear rna seq confirm cell type specif inform common distinct pathway associ tle astrocyt opc neuron compar postmortem control transcriptom epilepsi astrocyt show downregul matur astrocyt function upregul develop relat gene gain insight glial heterogen tle perform singl cell transcriptom scrna seq four addit human tle sampl analysi integr tle dataset uncov promin subpopul glia express hybrid signatur reactiv astrocyt opc marker includ mani cell mix gfap olig phenotyp integr analysi tle scrna seq dataset previous publish normal human tempor lobe scrna seq dataset confirm uniqu presenc hybrid glia tle pseudotim analysi reveal cell transit trajectori stem hybrid popul toward opc reactiv astrocyt immunofluoresc studi human tle sampl confirm rare presenc gfap olig glia includ cell prolif activ function analysi cell isol direct sampl disclos abnorm neurospher format vitro overal cell type specif isol glia surgic epilepsi sampl combin transcriptom analys uncov abnorm glial subpopul de differenti phenotyp motiv studi dysfunct role reactiv glia tempor lobe epilepsi
D004833
T047
36,274,167
product first function antibodi mimet higher plant chloroplast make darpin g imag oncolog design mimet molecul attract tool biopharmaceut synthet biolog requir mass function product assess upcom challeng near futur darpin famili consid mimet pharmaceut peptid group high affin bind specif target darpin g design bind human epiderm growth factor receptor tyrosin kinas receptor overexpress common cancer includ breast cancer use prognost predict tool cancer chloroplast cost effect altern equal sometim better bacteri yeast mammalian express system research examin possibl product first antibodi mimet darpin g tobacco chloroplast imag oncolog
D000090922;D001688
T123;T121;T116
36,274,166
use ceram block graft compar autogen block graft rehabilit atroph maxilla random control clinic trial dental implant placement may requir bone graft vertic horizont alveolar ridg augment due osteoconduct osteoinduct osteogenesi autogen bone graft characterist consid standard gold treatment howev autograft promot postop morbid implic difficulti concern graft adapt recipi bone sinc eventu avoid gap overcom issu trial compar perform plenum oss fit alloplast graft print patient specif graft base tricalcium phosphat autograft procedur
D018786;D015921
T122;T074
36,274,163
phase ii trial daratumumab dcep relapsedrefractori multipl myeloma patient extramedullari diseas extramedullari multipl myeloma emd aggress subent multipl myeloma mm poor prognosi innov therapeut approach need treatment mm emd conduct multicent non random phase ii trial daratumumab combin dexamethason cyclophosphamid etoposid cisplatin dara dcep total patient median age rang treat dara dcep base best respons studi complet remiss cr rate overal respons rate orr median follow month median progress free surviv pfs month median overal surviv os month long term respond whose median pfs reach common grade hematolog ae thrombocytopenia common non hematolog ae nausea follow dyspepsia diarrhea stomat grade daratumumab infus relat reaction note patient except plan dose adjust cycl patient requir dcep dose reduct one prospect trial focus emd success laid ground implement immunochemotherapi mm treatment
D000971;D009101;D009364
T061;T191
36,274,162
plastic leachat impair picophytoplankton dramat reshap marin microbiom year approxim million metric ton plastic wast enter ocean potenti advers impact trophic level understand impact plastic pollut marin microorgan larg restrict microbi assemblag colon plastic particl howev plastic debri also leach consider amount chemic addit water potenti impact key group plankton marin microb organ attach plastic surfac
D014874;D064307
T001;T131;T032;T028
36,274,161
revers cancer gene express identifi repurpos drug diffus intrins pontin glioma diffus intrins pontin glioma dipg aggress incur brainstem tumor target young children complet resect possibl chemotherapi radiotherapi current palliat studi aim identifi potenti therapeut agent use comput pipelin perform silico screen novel drug test identifi drug panel patient deriv dipg cell line use systemat comput approach public avail databas gene signatur dipg patient cancer cell line treat librari clinic avail drug identifi drug hit abil revers dipg gene signatur one match normal tissu background biolog molecular effect drug treatment analyz cell viabil assay rna sequenc vivo dipg mous model surviv studi also conduct result two three identifi drug show potenc dipg cell line triptolid mycophenol mofetil mmf demonstr signific inhibit cell viabil dipg cell line guanosin rescu reduc cell viabil induc mmf vivo mmf treatment signific inhibit tumor growth subcutan xenograft mice model conclus identifi clinic avail drug abil revers dipg gene signatur anti dipg activ vitro vivo novel approach repurpos drug signific decreas cost time normal requir drug discoveri
D000080443;D005910;D020295;D001254
T191
36,274,158
effect progesteron administr male femal smoker nicotin withdraw neural respons smoke cue role progesteron convers allopregnanolon progesteron administr therapeut effect tobacco use disord tud femal benefit male convers progesteron neurosteroid allopregnanolon hypothes part underli therapeut effect progesteron howev investig clinic
D000081227;D013375
T123;T184;T048;T109
36,274,157
ecolog driver dog heartworm transmiss california effect control heartworm diseas major parasit diseas threaten anim health us global requir understand local ecolog mosquito vector involv transmiss howev key vector speci given region often unknown challeng identifi investig key vector speci associ transmiss parasit dirofilaria immiti california ii climat land cover driver vector presenc
D004183;D004283;D000330
T047;T204
36,274,155
improv upper limb function non ambul children sma type nusinersen treatment prospect year smartcar registri studi develop approv diseas modifi treatment dramat chang diseas progress patient spinal muscular atrophi sma nusinersen approv europ treatment sma patient irrespect age diseas sever data therapeut efficaci avail infantil onset sma patient sma type type still lack suffici evid long term experi nusinersen treatment report data smartcar registri non ambul children sma type typen nusinersen treatment follow period month
D014897;D009134
T047
36,274,154
bile acid distribut sex specif prognosi colorect cancer bile acid known genotox contribut colorect cancer crc howev link crc tumor bile acid tumor locat patient sex microbiom immun regulatori cell prognosi clear
D015179;D003110
T191
36,274,153
hope express birth plan women diagnos fetal anomali qualit studi japan recent advanc prenat screen diagnosi result increas number women receiv diagnosi fetal anomali studi aim clarifi hope childbirth parent women diagnos fetal anomali suggest famili center care tailor situat perinat set
D065026;D000013;D011296
T060;T019;T041
36,274,151
tempor associ leukocyt dna methyl blood lipid longitudin studi associ blood lipid dna methyl investig epigenom wide associ studi main among european ancestri popul sever studi explor direct associ use cross section data evid longitudin data still lack
D019175;D044127
T045;T044
36,274,150
trajectori h movement guidelin middl adolesc adulthood depress suicid ideat year follow studi h movement guidelin youth adult recommend specif durat physic activ sedentari time sleep durat ensur optim health littl known relationship mental health indic aim studi explor associ h movement guidelin adolesc trajectori middl adolesc year old adulthood year old depress suicid ideat adulthood
D059020;D003863
T033;T184;T048
36,274,149
isol giant renal hydatid cyst simpl renal cyst appear case report isol renal hydatid cyst kidney rare occurr account hydatidos stay asymptomat year could variabl present imag techniqu result challeng diagnost process
D004443;D007680;D052177;D003560
T047;T191;T190
36,274,148
potenti contribut earli endotheli progenitor cell eepc macrophag switch develop pulmonari plexogen lesion plexiform lesion dynam appear structur cellular composit histolog hallmark sever pulmonari arteri hypertens human pathogenesi lesion develop remain larg unknown although may relat local inflamm dysfunct earli progenitor endotheli cell eepc test hypothesi eepc contribut develop plexiform lesion differenti macrophag set chronic inflamm
D066026;D006976
T046;T025
36,274,147
solubl cd biomark target prevent resist anti angiogen therapi glioblastoma glioblastoma multiform gbm primari brain tumor poor prognosi us food drug administr approv use anti vegf antibodi bevacizumab recurr gbm howev resist treatment frequent fail enhanc overal surviv patient studi aim identifi novel mechan respons bevacizumab resist cd posit glioblastoma
D005909;D001932
T191
36,274,146
attitud train relat substanc use pediatr emerg depart recent year pediatr emerg depart ped seen increas present relat substanc use among adolesc patient popul aim examin pediatr emerg medicin pem physician knowledg attitud belief care adolesc substanc use
D004635;D019966;D002047;D013375
T121;T184;T091;T109;T033;T048
36,274,145
retrospect review vaccin wastag associ risk factor littor region cameroon immun effect prevent health intervent cameroon expand program immun epi aim vaccin children year age free vaccin coverag consist remain nation target vaccin distribut base target popul size factor wastag norm howev vaccin wastag rate vwr may differ among various set studi aim assess vaccin wastag differ site set season vaccin type comparison vaccin coverag order provid comprehens insight vaccin wastag
D001500;D017589
T129;T058;T121;T116
36,274,144
myocyt androgen receptor overexpress affect sex differ adapt chronic endur exercis muscl specif androgen receptor ar overexpress hsaar transgen sedentari male rat result reduc adipos increas mitochondri enzym activ select increas type b myofib size test chronic endur exercis interact phenotyp sex across week rat ran week motor run wheel increas speed durat exercis reduc fat mass group sex affect endur exercis outcom absolut lean mass increas femal total bodi mass decreas male expect sex differ observ male exhibit greater total bodi lean mass absolut relat fat mass bone miner densiti extensor digitorum longus edl myofib size glycolyt proport lesser type type myosin express tibiali anterior observ hsaar outcom alter sex transgen rat greater lean mass type myosin express soleus glycolyt myofib size edl tibiali ar content independ affect sex hsaar exercis sex differ observ tibiali ar express wild type rat although hsaar male greater ar content hsaar femal identifi moder correl ar express glycolyt myofib size whole bodi composit overal result suggest myocyt ar overexpress chronic exercis despit share similar phenotyp adapt mediat distinct mechan studi illustr sex differ adapt chronic endur exercis suggest sex similar relationship muscl ar exercis respons
D010805
T038
36,274,143
health insur status cross border migrant children associ factor studi thai myanmar border area although polici thailand migrant health protect inclus migrant group due exist constraint practic polici implement mani migrant children still lack protect studi aim assess health insur status children age whose parent cross border migrant worker thailand factor relat status
D014171
T098
36,274,142
new anti cancer explor base metal ion due urgent demand anti cancer method new applic metal ion cancer attract increas attent especi three kind new mode cell death includ ferroptosi calcicoptosi cuproptosi great concern meanwhil mani metal ion found induc cell death differ approach interf osmot pressur trigger biocatalysi activ immun pathway generat prooxid effect therefor varieti new strategi base approach studi appli anti cancer applic moreov mani contrast agent base metal ion gradual becom core compon bioimag technolog mri ct fluoresc imag exhibit guid signific cancer diagnosi besid new nano theranost platform base metal ion experiment shown effici respons endogen exogen stimuli realiz simultan cancer therapi diagnosi control nano system howev metal base agent still earli stage control clinic trial necessari confirm current expect articl focus new explor base metal ion hope provid theoret support anti cancer idea
D003287;D009369
T191;T130
36,274,141
sub chronic oral toxic screen quercetin mice quercetin organ flavonoid present sever fruit veget anti inflammatori antivir antioxid cardio protect anti carcinogen neuroprotect properti demonstr dietari supplement endors possibl treatment inflammatori diseas cancer unfortun conflict research cast uncertainti toxic quercetin main purpos studi determin quercetin toxic properti mice dose shown efficaci pre clinic studi regard cancer cancer therapi target effect
D011794;D000975
T121;T123;T127;T109;T039;T044
36,274,140
evalu effect gentamicin surgic perfus solut cataract postop endophthalm evalu effect gentamicin surgic perfus solut endophthalm incid cataract surgeri
D009877;D013203;D002386
T033;T047;T190
36,274,139
compar studi antimicrobi activ mono rhamnolipid di rhamnolipid explor cost effect antimicrobi agent agricultur applic chemic pesticid defect crop diseas control narrow antimicrobi spectrum chemic residu risk harm farmland ecosystem antimicrobi agent microbi sourc high interest agricultur studi show rhamnolipid biosurfact possess certain antimicrobi activ structur differ rhamnolipid inevit affect activ antimicrobi effect mono rhamnolipid di rhamnolipid unknown rhamnolipid uniqu structur produc use specif microbi cell factori
D000890;D010575
T121;T131
36,274,138
tempor trend burden non communic diseas countri highest malaria burden evalu doubl burden non communic communic diseas epidemiolog transit non communic diseas ncds rapid increas sub saharan african countri global malaria death occur studi aim investig diseas burden ncds countri current highest malaria mortal
D000073296;D000544;D003924;D003141;D008288
T047;T048
36,274,137
inbreed pedigre analysi european red dairi cattl red dairi cattl breed import role european dairi sector function characterist good health extens pedigre inform avail breed provid uniqu opportun examin popul structur effect popul size depth pedigre effect number founder ancestor inbreed level anim highest genet contribut identifi pedigre data includ anim born denmark finland germani latvia lithuania netherland norway poland sweden cover breed numer largest breed red dairi cattl meus rhine yssel
D007178;D014644
T040;T070
36,274,136
multidisciplinari manag dissemin exophiala dermatitidi mycosi infant mix phenotyp acut leukemia case report exophiala dermatitidi dematiac fungus isol various environment sourc system e dermatitidi infect lead fatal outcom treatment yet standard although e dermatitidi also known caus cutan infect previous report appear ecthyma gangrenosum eg uncommon cutan lesion neutropen patient main caus pseudomona aeruginosa
D009181;D004473;D007938
T047;T191
36,274,135
import set therapeut relationship deliv chiropract care live disadvantag chiropract most privatis health profess within australia peopl experienc disadvantag typic limit access due financi barrier howev univers within australia offer communiti outreach clinic student provid chiropract care peopl live disadvantag demograph experi higher rate chronic condit includ musculoskelet complaint requir subsidis access privatis care need also offer opportun chiropract profess work within communiti healthcar team mix method observ studi use investig uniqu set student chiropract communiti clinic may influenc experi outcom attend
D002684;D026882
T061;T091
36,274,134
lncrna pcedb knockdown inhibit osteosarcoma via methyl mediat mir downregul lncrna pcedb pcedb promot glioma studi aim investig role osteosarcoma os
D001859;D035683;D012516;D062085
T123;T191;T114
36,274,133
feasibl outcom reproduc clinic interpret high dimension molecular data comparison two molecular tumor board structur harmon implement molecular tumor board mtb clinic interpret molecular data present current challeng precis oncolog heterogen interpret molecular data shown patient even limit number molecular alter integr high dimension molecular data includ rna rna seq whole exom sequenc wes expect complic clinic applic analyz challeng mtb harmon base complex molecular dataset retrospect compar clinic interpret wes rna seq data two independ molecular tumor board
D059014;D009369
T063;T191;T059
36,274,132
downregul tusc promot emt hepatocellular carcinoma progress lipcakt axi hepatocellular carcinoma hcc one common malign tumor digest tract tumor suppressor candid tusc one subunit endoplasm reticulum oligosaccharyl transferas ost complex play import role n glycosyl protein fold process howev role tusc initi progress hcc mention yet present studi aim investig effect tusc initi progress hcc
D006528;D058750;D008113
T191;T043
36,274,131
empir evalu impact scenario pool bodi evid random control trial cohort studi medic research random control trial rcts cohort studi common studi design type use assess treatment effect medic intervent aim hypothet pool bodi evid boe rcts match boe cohort studi includ systemat review
D035843
T062
36,274,130
strengthen vaccin deliveri system resili context protract humanitarian crisi realist inform systemat review childhood vaccin among effect public health intervent avail prevent communic diseas coverag mani humanitarian set sub optim systemat review critic evalu peer review grey literatur evid effect system level intervent improv vaccin coverag protract crise focus work better inform prepared respons futur crise
D014611;D017589
T061;T058
36,274,129
echinodb updat web base applic genom transcriptom data echinoderm releas new version echinodb echinodb v https echinodbunccedu echinodb databas genom transcriptom data echinoderm initi databas consist group ortholog paralog transcript arrang orthoclust sequenc similar
D059467;D004447
T081;T204;T086
36,274,127
cluster characterist associ unplan pregnanc generat r studi unplan unintend pregnanc form major public health concern associ unfavor birth outcom well social advers stress depress among parent sever risk factor unplan pregnanc women previous identifi studi usual take unidimension approach focus one factor disregard possibl predictor might cluster furthermor data predictor men larg overlook purpos studi determin predictor unplan versus plan pregnanc determin predictor ambival feel regard pregnanc investig characterist men women unplan pregnanc cluster togeth
D049168;D005193
T033;T058
36,274,126
impact flood undernutrit among children five year age low middl incom countri systemat review weather climat relat disast includ flood impact undernutrit multipl pathway includ food secur inadequ child care practic water sanit review aim provid systemat evid impact flood undernutrit children five year age low middl incom countri lmic
D003906;D044342
T047;T080
36,274,125
studi design interdisciplinari participatori natur base palliat rehabilit intervent danish nurs home peopl sever dementia limit amount research examin natur base palliat rehabilit implement nurs home peopl dementia even though evid suggest garden underus paper present studi protocol intervent studi co design interdisciplinari collabor nurs home peopl dementia develop tailor natur base palliat rehabilit program increas qualifi use garden purpos promot rang health outcom
D009735;D003704
T073;T093;T048
36,274,124
addison diseas trigger infect mycobacterium abscessus adren tuberculosi mac pulmonari diseas subject type diabet mellitus case report addison diseas primari adren dysfunct character decreas cortisol level increas adrenocorticotrop hormon acth level known infect one main caus addison diseas among various infect tubercul infect account major recent number subject non tubercul mycobacteri infect increas infect also bring addison diseas mycobacterium avium complex mac pulmonari diseas account major non tubercul mycobacteri infect
D000224;D000073358;D003924;D014376;D008171
T047;T007
36,274,123
medium develop product carotenoid exopolysaccharid extremophil rhodothermus marinus dsm glucos base defin media marin thermophil bacterium rhodothermus marinus degrad mani polysaccharid make interest futur cell factori progress use bacterium howev hamper limit knowledg media condit biomass product often result low cell yield low product highlight need develop condit allow studi microb molecular level studi present develop defin condit support growth combin evalu product carotenoid exopolysaccharid epss r marinus strain dsm
D000071825;D014131
T123;T196;T121;T001
36,274,122
clinskat r packag conduct associ analysi use function relev variant avail next generat sequenc data allow low frequenc rare variant studi strategi common use genom wide associ studi gwas rare variant import key toward explain herit complex diseas remain explain common variant due low effect size howev analysi strategi struggl keep huge amount data dispos therefor creat bottleneck studi describ clinskat r packag provid user easili implement analysi pipelin goal extract clinic relev variant rare common follow ii gene base associ analysi group select variant
D055106;D059472
T063;T028
36,274,121
polyhaplotyp haplotyp polyploid base bi allel marker dosag data genet analys multi allel marker advantag bi allel marker like snps singl nucleotid polymorph carri inform genet constitut individu especi case polyploid individu carri two allel locus haploblock multi allel marker deriv phase set close link snp marker phase haploblock similar multi allel marker therefor advantag genet task like linkag map qtl map genom wide associ studi
D055106;D011123
T063;T049;T025
36,274,120
silver nano report enabl simpl ultrasensit profil microrna nanoflow like microelectrod array glass microrna mirna small non code rnas nucleotid play import role post transcript regul gene express express profil mani mirna close relat occurr progress cancer use biomark cancer diagnosi prognosi howev intrins properti short length low abund high sequenc homolog repres great challeng mirna detect clinic sampl overcom challeng develop simpl ultrasensit detect platform electrochem mirna chip e mirchip novel signal amplif strategi use silver nanoparticl report agnr multiplex direct electron profil mirna two step hybrid strategi use detect mirna target mirna hybrid stem loop probe unlock probe first open stem loop hybrid agnr signal amplif enhanc detect sensit gold nanoflow electrod gnes construct microapertur array e mirchip electropl optim size gnes e mirchip show excel perform mir detect detect limit fm linear rang extend fm pm e mirchip also exhibit good specif differenti base mismatch sequenc target mirna addit e mirchip abl direct detect mir express total rna extract cell lysat collect lung cancer cell normal cell work demonstr develop e mirchip effici promis miniatur point care diagnost devic earli diagnosi prognosi cancer
D035683;D053768;D015374
T123;T073;T075;T059;T114
36,274,119
iranian multi center osteoporosi studi imo studi protocol paper present protocol th round iranian multi center osteoporosi studi imo nation survey primari object estim preval osteoporosi sarcopenia risk factor repres sampl urban rural popul
D010024;D055948
T047
36,274,118
human resourc need cost hiv pre exposur prophylaxi provis nurs led primari care eswatini opportun task share global expans hiv pre exposur prophylaxi prep includ health system face shortag skill health care worker hcws estim human resourc need cost provid prep nurs led primari care clinic eswatini furthermor assess potenti cost save task share nurs hcw cadr
D065129;D019380;D015658
T061;T121;T047
36,274,116
target denv nsb ns proteas activ antivir phytocompound structur base virtual screen molecular dock molecular dynam simul studi dengu fever global health concern mitig challeng problem due non avail workabl treatment difficult object design perfect anti dengu agent capabl inhibit infect caus four serotyp various tactic employ past discov dengu antivir includ screen chemic compound dengu virus enzym object current studi investig phytocompound anti dengu remedi target non structur b non structur proteas nsb ns pro possibl therapeut target dengu fever initi antivir phytocompound collect duke phytochem ethnobotan databas phytocompound anti dengu properti identifi previous report studi virtual screen nsb ns pro use molecular dock toxic evalu top five screen ligand naringin hesperidin gossypol maslin acid rhodiolin bind affin kcalmol kcalmol kcalmol kcalmol kcalmol respect finest dock compound complex nsb ns pro subject molecular dynam md simul bind free energi estim molecular mechan general born surfac area base calcul result studi intrigu context comput aid screen bind affin phytocompound propos maslin acid mas potent bioactiv antivir develop phytocompound base anti dengu agent
D003716;D006072;D006569;D003715
T123;T121;T127;T109;T131;T005;T047
36,274,114
qualit quantit three dimension evalu maxillari basal dentoalveolar dimens patient without maxillari impact canin studi aim three dimension evalu qualit quantit maxillari basal dentoalveolar dental dimens patient unilater bilater maxillari impact canin relat normal peer
D003481;D014095
T023;T047
36,274,113
variabl noninvas mri biolog marker compens cirrhosi insight assess diseas progress annual monitor stabl compens cirrhosi cc patient evalu serial variat blood serum liver stiff multiparametr magnet reson imag mpmri measur provid refer chang valu rcv sampl size measur futur studi
D008103;D008279
T060;T047;T170;T059
36,274,112
cd cd express predictor ovarian cancer chemoresist immunohistochemistri flow cytometri studi convent standard treatment ovarian cancer effect diseas fatal women cancer stem cell cscs express cd cd contribut chemoresist poor prognosi seek investig express cscs cd cd ovarian cancer predict signific
D000077216;D019008;D010051
T191;T038;T042
36,274,105
intracrani direct electr map reveal function architectur human basal ganglia basal ganglia play key role integr varieti human behavior cortico basal ganglia thalamo cortic loop accord basal ganglia disturb implic broad rang debilit neuropsychiatr disord despit accumul knowledg basal ganglia function organ neural substrat circuitri subserv function direct map human direct electr stimul distinct basal ganglia region refractori epilepsi patient undergo stereoelectroencephalographi record offer current complet overview basal ganglia function character extend expect sensorimotor respons also vestibular sensat autonom respons cognit multimod effect specif locat identifi respons nt predict model deriv larg scale meta analys work may mark import step toward understand function architectur human basal ganglia provid mechanist explan non motor symptom brain circuit disord
D001479;D012677
T023;T042
36,274,104
slip mechan walk along curv path depend biomechan context slip onset curvilinear walk common caus limb radius depend asymmetri distinguish straight walk elev friction demand increas slip fall risk howev unclear aspect curvilinear walk influenc slip perturb experienc cross section examin three biomechan slip context slip onset phase slip foot relat path path radius influenc slip direct distanc peak veloc eighteen young adult experienc unconstrain insid outsid foot slip earli mid late stanc follow radius semicircular path deriv slip mechan motion captur data assess depend slip context use mix effect model slip onset phase progress slip direct exhibit anterior posterior transit shorten mediolater acceler anteroposterior slip foot modifi direct transit insid outsid foot slip move contralater ipsilater respect insid foot slip shorter slower mediolater longer anteroposterior outsid foot slip increas path radius caus slip greater mediolater direct compon show rang context depend slip possibl like due instantan magnitud orient shear ground reaction forc result contribut comprehens understand walk slip fall prevent method leverag
D005684;D016138
T033;T056;T169
36,274,096
retinoblastoma protein intrins brd inhibitor modul small molecul bet inhibitor sensit cancer bromodomain extratermin bet protein includ brd play import role oncogenesi immun inflamm demonstr cancer cell loss retinoblastoma rb tumor suppressor becam resist small molecul bromodomain inhibitor bet protein find rb bind bromodomain bd brd bind imped cdk mediat rb phosphoryl serin threonin st chip seq analysi show rb knockdown increas brd occup genom loci gene enrich cancer relat pathway includ gpcr gnbil creb axi st phosphoryl rb posit correl gnbil protein level prostat cancer patient sampl bet inhibitor resist rb defici cell abolish co administr creb inhibitor studi identifi rb protein bona fide intrins inhibitor brd demonstr rb inactiv confer resist small molecul bet inhibitor therebi reveal regulatori hub converg rb upstream signal onto brd function diseas cancer
D009369;D016160
T123;T191;T116
36,274,095
engin helicas replac thermocycl dna amplif retain desir pcr characterist polymeras chain reaction pcr essenti method molecular diagnost life scienc pcr requir thermal cycl heat dna strand separ cool replic process use special hardwar expos biomolecul temperatur c engin pcra helicas enhanc speed process replac heat step enzymat dna unwind retain desir pcr characterist name isotherm amplif method sharp ssb helicas assist rapid pcr use engin helicas singl strand dna bind protein ssb addit standard pcr reagent sharp generat amplicon length base pair sharp produc function dna plasmid impart cell antibiot resist amplifi specif fragment genom dna human cell use sharp assess outcom crispr cas edit endogen genom site
D004265;D021141
T059;T063;T126;T116
36,274,090
autom unsupervis deep learn base approach diabet retinopathi detect per intern diabet feder idf report peopl suffer diabet retinopathi dr histori diabet dr one primari reason blind visual impair worldwid among adult age year therefor research aim develop autom techniqu detect retin abnorm associ dr microaneurysm unsupervis learn high potenti data classif propos work accomplish follow object k mean fuzzi cluster method discuss object function revis offer modifi version name modifi fuzzi cluster method mdfcm b modifi convolut neural network propos consolid mdfcm featur better outcom c result compar three divers dataset diaretdb apto liverpool fuzzi cluster method deep embed cluster k mean generaliz best knowledg propos algorithm first detect dr use hybrid approach unsupervis deep learn methodolog propos system achiev improv accuraci rate result show propos method outperform state art algorithm intend design tool use propos system diabet retinopathi detect earli stage complet system flow architectur diabet retinopathi detect use unsupervis deep learn approach
D003930;D000077321;D003920
T047;T066
36,274,088
noncanon function eif limit aldhb activ increas suscept ferroptosi ferroptosi type lipid peroxid depend cell death emerg therapeut target cancer howev mechan ferroptosi generat detoxif lipid peroxid product remain rather poor defin report unexpect role eukaryot translat initi factor eif determin ferroptot sensit control lipid peroxid drug screen identifi egi ercat previous known eif eifg interact inhibitor power inhibitor ferroptosi genet function studi show eif eifg promot ferroptosi translat independ manner use mass spectrometri subsequ protein protein interact analysi identifi eif endogen repressor aldhb mitochondria aldhb belong famili aldehyd dehydrogenas may metabol aldehyd substrat hydroxynonen hne high concentr supraphysiolog level hne trigger ferroptosi low concentr hne increas cell suscept classic ferroptosi induc activ nox pathway accord eif depend aldhb inhibit enhanc anticanc activ ferroptosi induc vitro vivo result support key function eif orchestr lipid peroxid ignit ferroptosi
D039561;D000079403
T123;T116;T043
36,274,085
breadth sar cov neutral protect induc nanoparticl vaccin coronavirus vaccin high effect current anticip sar cov variant need control covid previous report receptor bind domain rbd sortas conjug ferritin nanoparticl scnp vaccin induc neutral antibodi sar cov pre emerg sarbecovirus protect non human primat nhps sar cov wa infect find rbd scnp induc neutral antibodi nhps pseudovirus sar cov sar cov variant includ g beta delta omicron ba ba ba baba design variant escap mutat pms adjuv studi demonstr variant neutral titer highest aqueous formul af immun twice rbd scnps protect nhps sar cov wa beta delta variant challeng protect mice challeng sar cov beta variant two heterolog sarbecovirus result demonstr abil rbd scnps induc broad neutral sar cov variant protect anim multipl differ sar relat virus vaccin could provid broad immun sar cov variant
D045473;D000086382;D014765;D053758
T129;T121;T073;T067;T005;T047
36,274,066
metabol control cd express lat mediat amino acid uptak promot tumor immun evas chemotherapi elicit tumor immun evas poor character mechan demonstr chemotherapi mark enhanc express level cd osteosarcoma tissu posit associ patient mortal reveal macrophag respons chemotherapi secret interleukin turn upregul express l amino acid transport lat tumor cell substanti enhanc uptak leucin glutamin two potent stimul mtorc increas level leucin enhanc glutaminolysi activ mtorc subsequ c myc mediat transcript cd deplet lat treatment tumor cell lat inhibitor downregul cd enhanc macrophag infiltr phagocytosi tumor cell sensit osteosarcoma doxorubicin treatment mice find unveil mutual regul macrophag tumor cell play critic role tumor immun evas underscor potenti interven lat mediat amino acid uptak improv cancer therapi
D001859;D051928;D012516;D027182
T129;T191;T123;T116
36,274,065
explor situ pair human galectin toward synthet mannosyl core glycopeptid dystroglycan dystroglycan dg constitut part dystrophin glycoprotein complex connect extracellular matrix cytoskeleton matriglycan present extracellular dg serv contact point extracellular matrix protein ecm contain laminin g like domain provid cellular stabil howev remain unknown whether core glcnac man structur serv ligand among various mannosyl glycan therefor base presenc n acetyllactosamin lacnac glycan follow core extens bind interact adhesiongrowth regulatori galectin explor elucid process interact galectin gal dg fragment trgaiiqtptlgpiqptrv core base glycopeptid librari profil use glycan microarray nuclear magnet reson studi bind galectin reveal irrespect modular architectur ad galectin list possibl bind partner dg core glycoconjug cis bind via peptid carbohydr protein interact abrog sialyl lacnac unit lacnac termin dg glycopeptid interact simultan f face gal therebi induc oligomer furthermor gal tran bridg dg core structur laminin propos possibl mechan gal amelior muscular dystrophi howev propos warrant investig
D049030;D006020
T123;T116
36,274,064
cryomicroscopi reveal structur basi flexibl hing motion immunoglobulin pentam immunoglobulin igm ancient five isotyp immunoglobulin ig molecul serv first line defenc pathogen use cryo em imag structur human full length igm pentam reveal antigen bind domain flexibl attach asymmetr rigid core form c c constant region j chain hing locat cc domain interfac allow fab c pivot unit plane plane motion differ observ igg iga two fab arm abl swing independ bias orient one pair fab arm result asymmetri constant domain c igm subunit interact extens j chain may influenc multi valent bind surfac associ antigen complement pathway activ comparison structur fc fragment igm monom similar pentam dynam c domain
D007141;D007070
T129;T116
36,274,063
purif structur character na transloc ferredoxin nad reductas rnf complex clostridium tetanomorphum various microbi metabol use h na transloc ferredoxin nad reductas rnf either exergon oxid reduc ferredoxin nad generat transmembran electrochem potenti revers exploit latter produc reduc ferredoxin cryo em structur analysi elabor quick four step purif protocol rnf complex clostridium tetanomorphum integr homogen activ enzym nanodisc obtain densiti map larg allow chain trace redox cofactor identif complement biochem data entir rnf singl subunit rnfb rnfc rnfg basi postul electron transfer rout ferredoxin nad via eight fe cluster one fe ion four flavin cross cell membran twice relat pathway nadh ubiquinon reductas redox coupl na transloc provid orchestr na uptakereleas electrostat effect assum membran integr fmn semiquinon anion accompani polypeptid rearrang mediat differ redox step
D005288;D048012
T123;T007;T116
36,274,062
detect preval sar cov co infect omicron variant circul franc decemb februari intens unpreced co circul sar cov variant high genet divers rais question possibl co infect variant detect use mix delta omicron isol differ ratio evalu perform differ set primer use whole genom sequenc develop unbias bioinformat method detect co infect involv genet distinct sar cov lineag appli sampl collect decemb februari random genom surveil franc detect co infect differ lineag preval delta omicron ba co infect omicron lineag ba ba co infect estim respect among hospit patient intens care unit icu admiss rate omicron delta deltaomicron patient respect baba co infect report among icu admit patient among co infect patient total patient vaccin although sar cov co infect rare studi proper detect crucial evalu clinic impact risk emerg potenti recombin
D000086382;D060085
T047;T067
36,274,061
mmp cleavag amino termin cd death receptor switch signal toward non apoptot pathway cd death receptor promot oncogenesi molecular mechan fulli elucid although matur cd membran receptor consid start arginin posit elimin signal peptid receptor also cleav mmp upstream leucin posit post translat modif occur cancer cell also normal cell peripher blood leukocyt non cleav cd amino termin region consist disord domain silico reconstitut suggest might contribut receptor aggreg therebi regul downstream death signal pathway agreement molecular model analysi comparison cd defici cell reconstitut full length n termin truncat cd reveal loss amino termin region cd impair initi step apoptot signal favor induct pro surviv signal includ pik mapk pathway
D019014;D020783
T129;T126;T116;T192
36,274,060
dysregul ceramid metabol fatti acid hydroxylas expos metabol vulner target cancer metastasi wherea appreci cancer cell rewir lipid metabol surviv propag role lipid metabol metastasi remain larg unknown studi use esophag squamous cell carcinoma escc pulmonari metastasi model find enzym fatti acid hydroxylas fah catalyz hydroxyl free fatti acid fas enrich subpopul escc cell high metastat potenti fah knockdown mark mitig metastat lesion moreov increas fah express posit associ poor surviv patient escc lipidom analysi identifi two dihydroceramid cer cer increas fah deplet metastas escc cell upon administr cer cer impair format overt metastas mous experiment metastasi model forkhead box protein c foxc fah found co upregul metastat escc cell popul escc specimen fah express experiment verifi transcript induc foxc boost per se tumour necrosi factor tnf critic pro metastasi cytokin tumour microenviron metastas cell togeth result demonstr tnf foxc fah novel signal axi promot metastasi downstream dihydroceramid product could promis drug interven metastasi
D000077277;D004938
T191
36,273,989
report nd workshop intern collabor advanc vaccinolog train workshop march leader advanc vaccinolog cours invit meet partner aim intern collabor advanc vaccinolog train icavt initi assist cours address challeng prioriti area facilit interact exchang inform includ updat landscap analysi advanc vaccinolog cours conduct share experi good practic implement virtual train review train need target audienc inform cours principl challeng ad valu accredit discuss cours evalu measur cours impact review principl support need qualiti cascad train review covid impact train identifi remain relat train need identifi solut facilit refresh cours way facilit network cours alumni particular virtual cours aim identifi need impedi implement necessari action facilit share inform resourc cours identifi need develop e portal collabor icavtorg establish facilit communic differ cours assist futur cours particip identifi suitabl cours discuss formal collabor workshop particip look sever report survey complet cours cours alumni partner covid pandem impact deliveri vaccinolog cours lead postpon deliveri onlin hybrid train event lack sustain fund remain major constraint advanc vaccinolog train need address collabor consolid respons benefit member better defin strong support collabor continu organ educ session futur workshop meet enforc view much enthusiasm commit global collabor core valu
D000078782;D000086382
T047;T091;T067
36,273,889
effect ccdafreud knockdown hippocampus btbr mice autist like behavior express serotonin ht dopamin receptor creb nf kb intracellular signal mechan autism extrem interest due high preval disord human popul regard special attent given transcript factor freud encod ccda gene regul numer intracellular signal pathway act silenc ht serotonin dopamin receptor disrupt freud function lead develop various psychopatholog studi found increas express ccdafreud gene hippocampus btbr mice model autist like behavior comparison cblj mice examin restor ccdafreud express hippocampus btbr mice affect behavior express ht serotonin dopamin receptor creb nf b intracellular signal pathway anim five week administr adeno associ viral vector aav carri paavh shrna freud synegfp plasmid encod small hairpin rna shrna suppress express ccdafreud gene observ elev anxieti level well increas escap latenc path length platform morri water maze test probabl associ strengthen activ stress avoid strategi howev ccdafreud knockdown affect spatial memori phosphoryl creb transcript factor although effect found cblj mice previous studi result suggest impair creb depend effector pathway btbr mice may play import role develop autist like phenotyp knockdown ccdafreud hippocampus btbr mice affect express ht serotonin dopamin receptor key nf b signal gene nfkb rela data suggest transcript factor freud play signific role pathogenesi anxieti activ stress avoid autism
D001321;D006624
T026;T023;T048
36,273,888
signific notch express progress human lung colorect cancer lung colorect cancer common type cancer character poor prognosi high mortal rate mutat gene encod compon main intra extracellular signal pathway particular notch gene notch member notch famili receptor play one key role progress malign notch signal involv maintain homeostasi intestin epithelium structur function lung element therefor surpris constitut activ hyperact notch signal due somat mutat gene code product direct involv activ could lead progress cancer type aim studi investig notch downregul via rna interfer rnai affect phenotyp characterist notch depend signal human lung hct colorect carcinoma cell sever small harpin rnas shrnas select use bioinformat analysi test abil suppress notch express effici one use produc hct cell notch knockdown obtain cell line demonstr decreas prolifer rate reduc coloni form capac adhes condit decreas migrat activ boyden chamber notch knockdown also signific decreas express notch signal target gene potenti involv acquisit mainten invas malign cell phenotyp vivo experi immunodefici athym femal balbc nunu mice confirm result obtain vitro notch inhibit decreas growth rate subcutan xenograft form hct tumor cell therefor downregul gene encod notch receptor potenti reduc malign characterist human lung colorect carcinoma cell
D015179;D008175;D051881
T191;T116;T192