PMID
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36.4M
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36,273,887
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identif channelrhodopsin gene green cryptophyt alga white black sea due uniqu capabl modul cell membran potenti upon photoactiv channelrhodopsin green chlorophyta cryptophyt cryptophyta alga wide employ optogenet modern method light depend regul biolog process enabl search new gene perspect optogenet develop pcr test presenc gene cation anion channelrhodopsin six isol green alga haematococcus bracteacoccus white sea region specimen rhodomona sp cryptophyta region white black sea analyz use pcr test demonstr known haematococcus rhodopsin gene discov novel rhodopsin gene genus bracteacoccus two distant homolog gene anion channelrhodopsin also identifi cryptophyt rhodomona sp white black sea result indic develop pcr test might use tool broad rang screen chlorophyta cryptophyta alga identifi uniqu channelrhodopsin gene
|
D044785;D012243
|
T123;T116;T204
|
36,273,886
|
compar absorpt dynam singlet excit state chlorophyl transient absorpt dynam chlorophyl dissolv tetrahydrofuran measur broadband femtosecond laser pump probe spectroscopi spectral rang nm absorpt spectra excit singlet state chlorophyl record dynam q band shift stimul emiss stoke shift fluoresc determin time rang fs ps kinet intramolecular convers q x q electron transit measur characterist relax time fs chlorophyl respect
|
D002734;D005663
|
T123;T109
|
36,273,885
|
caroten generat quench singlet oxygen comparison phytofluen known c carotenoid short chain conjug doubl bond cdb respect univers precursor biosynthesi color carotenoid plant cell previous use main stationari measur photosensit phosphoresc singlet oxygen discov phytofluen effici generat aerat solut therefor serv sourc uv photodynam stress live cell ashikhmin et al biochemistri moscow present paper use novel puls light emit diod led aerat hexafluorobenzen solvent time resolv measur phosphoresc confirm phytofluen effici photosensit format quantum yield process accord novel experi abil generat also found aerat solut caroten although quantum yield process fold lower phytofluen solut carotenoid found quench dark quench rate constant equal respect knowledg rate constant quench caroten report present paper first time follow data obtain rate constant quench carotenoid much order magnitud smaller rate constant diffus limit biomolecular reaction henc carotenoid weak protector oxid activ like potenti promot photodynam stress live cell
|
D026082;D024321
|
T123;T196;T109
|
36,273,884
|
lh complex sulfur bacteria allochromatium vinosum natur singlet oxygen sensor establish heterogen model system consist two type complex reaction center core complex photosystem higher plant lh complex sulfur bacterium alc vinosum bchl oxid lh complex could observ illumin light wavelength nm red absorpt band chl shown process induc releas singlet oxygen generat photosystem ii complex partial diffus lh complex oxid bchl establish hplc result format product bchl oxid acetylchlorophyl process bchl oxid inhibit singlet oxygen quencher trolox na ascorb suggest lh complex sulfur bacterium alc vinosum could use detect generat singlet oxygen chlorophyl contain sampl
|
D045342;D002841
|
T123;T007;T116
|
36,273,883
|
properti mutant photosynthet reaction center purpl non sulfur bacteria cereibact sphaeroid ilegln substitut structur photosynthet reaction center rc purpl bacterium cereibact sphaeroid high conserv amino acid residu ile locat near bacteriochlorophyl dimer p primari electron donor monomer bacteriochlorophyl b nearest electron acceptor sinc ile close c acetyl group bacteriochlorophyl p b hydroxyl group tyr c keto group bacteriochlorophyl b well water molecul near latter group site use introduc mutat order studi mechan primari photochem process rc previous shown ileglu substitut posit analog rc c sphaeroid rc close relat purpl non sulfur bacterium rhodobact capsulatus signific affect kinet p h state format wherea ilegln substitut led loss bchl b molecul complex structur present work shown singl q doubl q f amino acid substitut rc c sphaeroid chang pigment composit mark influenc redox potenti primari electron donor howev substitut ile gln affect posit amplitud absorpt band bacteriochlorophyl increas lifetim primari electron donor p excit state ps ps decreas quantum yield p q state format data suggest signific chang pigment protein interact vicin primari electron donor p nearest electron acceptor b consider decreas also notic resist mutant rc thermal denatur pronounc rc doubl substitut q f like associ disrupt dens pack protein near bacteriochlorophyl p b b possibl reason differ effect ident mutat properti two high homolog rcs close relat purpl non sulfur bacteria discuss
|
D045322;D012242
|
T123;T007;T116
|
36,273,882
|
effect dipyridamol membran energ energi transfer chromatophor rba sphaeroid effect dipyridamol dip concentr mm fluoresc characterist light harvest complex lh lh well condit photosynthet electron transport chain bacteri chromatophor rba sphaeroid investig dip found affect effici energi transfer light harvest complex lh lh reaction center core complex produc long wavelength red shift absorpt band light harvest bacteriochlorophyl molecul ir spectral region nm shift associ membran transit energ state shown dip abl reduc photooxid bacteriochlorophyl reaction center acceler electron flow along electron transport chain therebi stimul generat transmembran potenti chromatophor membran result import clarifi possibl mechan dip influenc activ membran bound function protein particular might signific interpret numer therapeut effect dip
|
D012242;D002856
|
T007;T025
|
36,273,881
|
select excit carotenoid allochromatium vinosum light harvest lh complex lead oxid bacteriochlorophyl mechan bacteriochlorophyl photooxid light harvest complex number purpl photosynthet bacteria complex excit carotenoid absorpt band remain unclear mani year use narrow band laser illumin measur action spectrum process spectral rang carotenoid bacteriochlorophyl shown bacteriochlorophyl excit result almost photooxid molecul carotenoid excit lead oxid quantum yield low valu yield enabl assumpt studi process initi triplet state main carotenoid complex number conjug doubl bond chain length n interact state oxygen facilit format though low effici excit singlet oxygen oxid bacteriochlorophyl carotenoid triplet state form process earlier studi singlet triplet fission obtain result point necess reconsid function carotenoid light harvest complex purpl bacteria
|
D001429;D002338
|
T123;T121;T109
|
36,273,880
|
mechan select chemic exchang bacteriopheophytin reaction center rhodobact sphaeroid r elucid mechan site select chemic replac chromophor reaction center rcs photosynthet bacteria extern pigment investig effici incorpor plant pheophytin pheo bind site bacteriopheophytin molecul bpheo isol rhodobact sphaeroid r rcs depend incub medium temperatur pheo aggreg state presenc organ solvent aceton pheo form monom free deterg micell water deterg incub medium degre select replac photochem inact bpheo h b molecul upon incub rcpheo mixtur c exchang effici increas upon incub c reach temperatur aceton ad incub medium c degre pigment exchang increas approxim twice mixtur pheo monom dimer presenc aceton use incub medium remov aceton medium preserv pigment form led signific decreas effici pheo incorpor effect aceton pigment exchang also observ elev incub temperatur c function activ bpheo h molecul partial replac result discuss term mechan accord temperatur depend intern movement rc protein facilit releas bpheo molecul bind site simultan insert pheo molecul site coupl process ii role temperatur larg depend steric access bind pocket rc protein iii incorpor pheo occur pool monomer molecul includ rc deterg micell iv presenc aceton incub medium facilit exchang pheo monom micell solut deterg belt rc complex
|
D012242;D045322
|
T123;T007;T116
|
36,273,879
|
chang electron transfer symmetri photosystem reaction center upon remov iron sulfur cluster photosynthet reaction center intact photosystem psi complex cyanobacteria electron transfer room temperatur occur along two symmetr branch redox cofactor b ratio favor branch previous indirect demonstr use puls absorpt spectroscopi direct measur decay modul frequenc electron spin echo signal electron spin echo envelop modul eseem allow determin distanc separ charg primari electron donor p phylloquinon acceptor b symmetr redox cofactor branch b present work distanc determin use eseem psi complex lack three fe cluster f x f f b psac protein subunit call p core phylloquinon molecul b serv termin electron acceptor shown p core prepar averag distanc center p ion radic pair temperatur k aqueous glycerol solut dri trehalos matrix well trehalos matrix k correspond symmetr electron transfer along b branch redox cofactor ratio possibl reason chang electron transfer symmetri psi upon remov psac subunit fe cluster f x f f b discuss
|
D045331;D007506
|
T026;T123;T126;T116
|
36,273,878
|
hydrogen product co depriv photoautotroph chlamydomona reinhardtii cultur light depend hydrogen product microalga attract attent research potenti practic applic general recogn calvin benson bassham cycl compet hydrogen product process electron substrat co limit cycl increas hydrogen product rate furthermor photosystem ii destroy co defici studi photoautotroph cultur chlamydomona reimhardtii co defici flow air remov co cultur reach stationari phase growth photosystem ii downregul due overreduct plastoquinon pool follow degrad entir photosynthet machineri ar flow absenc co cultur brought microaerob condit produc small amount hydrogen ml h day liter cultur similar case incub air atmospher prolong incub cultur microaerob condit result regul photosystem ii due overreduct plastoquinon pool follow degrad whole photosynthet machineri follow remov co transfer cultur dark anaerob condit h illumin low intens light result cultur produc h high initi rate total microalg hydrogen product condit ml h liter cultur thus co depriv photoautotroph cultur produc hydrogen hydrogen product limit toxic effect oxygen hydrogenas calvin benson bassham cycl competit hydrogen product process
|
D016825;D006864
|
T126;T116;T204
|
36,273,877
|
plastoquinol oxid rate limit stage electron transport chain chloroplast work devot theoret studi function cytochrom cyt b f complex plastoquinol plastocyanin oxidoreductas electron transport chain etc oxygen photosynthesi composit chloroplast etc molecular mechan function cyt b f complex stand photosystem ii psii psi briefli review cyt b f complex oxid plastoquinol pqh molecul form psii reduc plastocyanin serv electron donor psi pqh oxid rate limit step chain electron transfer process psii psi use densiti function theori dft method analyz two electron bifurc oxid pqh catalyt center q cyt b f complex result dft calcul consist fact first step pqh oxid electron transfer fes cluster iron sulfur protein isp endergon energi accept process e kjmol limit turnov cyt b f complex second stage bifurc oxid pqh electron transfer semiquinon pqh form first step pqh oxid heme b l exergon energi donat process e dft model stage reveal semiquinon oxid acceler pqh radic shift toward heme b l electron acceptor carboxi group glu proton acceptor data obtain discuss within framework mitchel q cycl model describ pqh oxid q site cyt b f complex
|
D010970;D007506
|
T123;T116
|
36,273,876
|
mathemat simul electron transport primari photosynthet process summar result investig regul electron transport associ process photosynthet membran use method mathemat comput model carri depart biophys faculti biolog lomonosov moscow state univers present review detail kinet model process thylakoid membran develop use apparatus differenti equat fit model curv data spectral measur allow us estim valu paramet determin direct experi probabilist method agent base mont carlo model provid ampl opportun studi dynam heterogen system base rule behavior individu element system algorithm simplifi represent big data make possibl monitor chang photosynthet apparatus cours cultur growth photobioreactor purpos environment monitor brownian molecular model describ movement interact individu electron carrier protein make possibl studi electrostat hydrophob interact lead regul conform chang reaction complex direct multiparticl model explicit simul brownian diffus mobil protein carrier electrostat interact multienzym complex solut heterogen interior biomembran combin use method kinet brownian multiparticl molecular model make possibl studi mechan regul integr system electron transport process plant alga molecular subcellular level
|
D010788;D010944
|
T039;T070;T002;T044
|
36,273,850
|
impact differ endometri prepar protocol frozen embryo transfer pregnanc outcom review use frozen embryo transfer cycl exponenti increas last year optim endometri prepar protocol frozen embryo transfer mandatori improv pregnanc outcom review focus exist literatur regard differ avail endometri prepar protocol impact pregnanc outcom specif focus program natur stimul frozen embryo transfer cycl studi perform topic general low qualiti well perform random control trial publish date strong evid avail support use prepar method anoth term pregnanc outcom howev robust data shown clear protect effect natur frozen embryo transfer cycl long term obstetr complic main hypertens disord pregnanc larg gestat age infant introduct individu luteal phase support differ endometri prepar protocol actual gain lot attent requir investig
|
D015925;D004624
|
T061;T059
|
36,273,831
|
aga clinic practic guidelin pharmacolog intervent adult obes pharmacolog manag obes improv outcom decreas risk obes relat complic american gastroenterolog associ guidelin intend support practition decis pharmacolog intervent overweight obes
|
D019440
|
T121
|
36,273,819
|
dazl regul prolifer human primordi germ cell direct bind precursor mirna enhanc dicer process activ understand molecular cellular mechan human primordi germ cell hpgcs essenti studi infertil germ cell tumorigenesi mani rna bind protein rbps non code rnas specif express function hpgc develop howev role regulatori mechan rbps non code rnas microrna mirna hpgcs remain elus studi report new regulatori function dazl germ cell specif rbp mirna biogenesi cell prolifer first dazl co local mirna let human pgcs regul level gt matur mirna includ eight nine let famili mir mir mir mir mir purifi dazl direct bound loop precursor mirna sequenc specif guu bind dazl precursor mirna increas matur mirna enhanc cleavag activ dicer furthermor cell prolifer assay cell cycl analysi confirm dazl inhibit prolifer vitro pgcs promot matur mirna evid matur mirna regul dazl silenc cell prolifer regul includ trim moreov dazl inhibit germlin tumor cell prolifer teratoma format result demonstr dazl regul hpgc prolifer enhanc mirna process
|
D035683
|
T123;T114
|
36,273,767
|
attenu level pro inflammatori cytokin prevent depress like behavior ethanol withdraw mice clinic studi indic alcohol depend patient may develop depress symptom abstin may increas likelihood relaps known alcohol exposur depress increas level pro inflammatori cytokin brain howev putat contribut increas level pro inflammatori cytokin develop depress like behavior ethanol withdraw evalu present studi aim investig ethanol withdraw induc depress like behavior relat increas level pro inflammatori cytokin brain male mice treat vehicl salin vo ethanol gkg vo day day cessat ethanol treatment mice subject forc swim test fst tail suspens test tst open field test oft sacrif brain analyz level pro inflammatori cytokin ethanol withdraw mice show increas immobl time fst tst control group indic increas depress like behavior alter oft observ ethanol withdraw increas level tumor necrosi factor alpha tnf hippocampus striatum interleukin beta il hippocampus il prefront cortex hippocampus treatment mice nimesulid mgkgday cyclooxygenas inhibitor ethanol withdraw prevent increas immobl time tst similar result observ fst upon nimesulid treatment although higher dose nimesulid treatment mgkg prevent ethanol withdraw induc alter level tnf il il hippocampus prefront cortex striatum treatment mice atyp antidepress drug vilazodon mgkg prevent increas depress like behavior induc ethanol withdraw tst fst increas immobl time prevent mgkg vilazodon treatment vilazodon prevent increas level tnf il il hippocampus il prefront cortex tnf striatum conclus data indic increas level pro inflammatori cytokin may play role develop depress like behavior ethanol withdraw mice
|
D016207;D000437
|
T129;T116;T048
|
36,273,766
|
pilot scale studi biomethan biolog trickl bed reactor convert impur co full scale bioga plant research within biolog methan great develop use biotrickl filter btf power x solut research within scale miss studi investig commerci potenti biomethan btf oper two reactor implement full scale bioga plant sever area investig enrich start long term steadi state oper serial oper intermitt feed methan product formula see text product gas ch obtain parallel oper wherea serial oper methan product formula see text ch achiev flexibl biomethan demonstr unintent loss h feed period h initi perform regain within h result studi demonstr potenti commerci use biomethan btf futur power x solut
|
D056804;D008697
|
T109
|
36,273,748
|
tubiechong patch promot tibia fractur heal rat regul angiogenesi vegferk signal pathway extern use tradit chines medicin tcm treat fractur long histori clinic applic theoret basi also one characterist treatment method tcm signific efficaci mani advantag among common use extern chines medicin tubiechong noteworthi
|
D017102;D042461
|
T123;T116;T042
|
36,273,747
|
qi gong wan amelior adipocyt hypertrophi inflamm adipos tissu pcos mous model nrfho cypb pathway integr network pharmacolog experiment valid vivo initi record yifang jiji ancient chines text qi gong wan qgw use treat obes women infertil qgw help promot follicular develop matur regul balanc serum hormon testosteron estradiol enhanc endometri recept improv waist circumfer amelior insulin resist contain eight herb pinellia ternata thunb makino banxia citrus maxima burm juhong poria coco schw wolf fule atractylod macrocephala koidz baizhu cyperus rotundus l xiangfu conioselinum anthriscoid chuanxiong chuanxiong massa medicata fermentata shenqu glycyrrhiza uralensi fisch ex dc gancao howev under mechan qgw affect women pcos remain unclear
|
D007333;D011085;D064906
|
T061;T047;T046
|
36,273,695
|
exposur environment relev dose plastic alter matern behavior relat neuroendocrin process primipar multipar femal mice phthalat organ pollut frequent detect environ effect substanc male reproduct extens studi potenti impact femal reproduct behavior particular environment dose still remain document present studi examin effect chronic exposur di ethylhexyl phthalat dehp alon gkgd environment phthalat mixtur matern behavior lactat femal mice first primipar second gestat multipar exposur dehp alon phthalat mixtur reduc pup direct behavior increas self care forc nurs behavior alter nest qualiti primipar multipar dam pup retriev test primipar multipar dam expos dehp alon phthalat mixtur retriev pup rapid probabl due higher emiss ultrason vocal pup lactat day follow third last gestat period neural circuitri matern behavior analyz lower number oxytocin immunoreact neuron paraventricular anterior commissur nuclei found dam expos dehp alon phthalat mixtur chang observ number arginin vasopressin immunoreact cell medial preoptic area exposur dehp alon phthalat mixtur reduc er immunoreact cell number dendrit spine densiti assess dehp gkgd also reduc thus exposur dehp alon phthalat mixtur alter matern behavior probabl neuroendocrin mode action involv oxytocin estrogen er key pathway necessari neuroplast behavior process
|
D004051;D011297;D052244
|
T109;T131;T122;T037;T039
|
36,273,692
|
polystyren microplast ingest induc damag digest gland amphioctopus fangsiao physiolog inflammatori metabolom transcriptom level microplast ubiquit aquat terrestri ecosystem increas becom serious concern aquat organ health howev inform regard effect microplast cephalopod remain limit date amphioctopus fangsiao import econom speci cephalopod serv potenti indic environment pollut due short life expect high metabol rate explor toxic effect microplast stress respons analyz growth perform histopatholog damag oxid stress biomark metabolom transcriptom respons digest gland fangsiao differ concentr gl commerci polystyren microplast mps exposur sphere day result show mps exert huge influenc growth perform fangsiao oxid stress inflamm digest gland fangsiao also detect exposur mps addit alter metabolit observ metabol analysi relat inflamm oxid stress glucolipid metabol transcriptom analysi detect differenti express gene deg signific enrich kegg pathway associ glycolipid metabol inflamm dna damag collect result indic excess environment microplast exposur caus toxic damag initi detoxif mechan fangsiao digest gland maintain homeostasi studi reveal microplast caus advers consequ cephalopod provid novel insight toxicolog effect microplast exposur
|
D000080545;D014874
|
T131;T122
|
36,273,689
|
microplast exposur aquat invertebr caus signific negat effect compar natur particl meta analysi mani studi report advers effect exposur microplast aquat organ still relat studi compar effect mps natur particl control make difficult separ particl effect chemic effect studi carri meta analysi studi compar effect mps natur particl aquat anim use three differ endpoint growth reproduct mortal analysi show mps capac induc advers effect growth reproduct mortal taxonom group howev effect exposur mps consist across endpoint taxonom group abl clear discern differ impact result exposur specif polym type shape though negat effect associ polylact acid polyethylen well fragment oppos bead fibr addit meta regress indic larger mp size higher experiment temperatur longer exposur period general associ advers effect futur studi continu make use negat particl control allow better risk assess microplast nanoplast aquat ecosystem
|
D000080545;D014874
|
T131;T122
|
36,273,622
|
fluorescenceelectrochemiluminesc approach instant detect glycat hemoglobin index percentag glycat hemoglobin hbac total hemoglobin hb import index diagnosi type ii diabet td reflect long term glucos level blood herein employ one pot co reduct approach use glutathion gsh structur direct agent cluster like auag nanoparticl auag nps materi synthes therefor electrochemiluminesc ecl aptam sensor hbac detect develop base function electrod materi meanwhil quantit determin total hb realiz base quench effect hb fluoresc fl luminol compat condit result index satisfactorili acquir multimod detect system good linear respons toward hb hbac blood test prove strategi capabl accur hb hbac detect thus obtain percentag hbac total hb hbac potenti applic clinic diagnosi diabet mellitus
|
D003924
|
T047
|
36,273,621
|
glh vasa repress neuropeptid express drive spermiogenesi c elegan germlin germ granul harbor process maintain germlin integr germlin stem cell capac deplet core germ granul compon c elegan lead reprogram germ cell caus express marker somat differenti day two adult somat reprogram associ complet steril stage result germ cell atrophi pleiotrop defect complic understand initi reprogram process within germ granul safeguard totipot immort potenti germlin stem cell better understand initi event somat reprogram examin total mrna transcriptom polysom associ mrna translatom chang precis full length delet glh encod homolog germlin specif vasaddx dead box rna helicas fertil anim permiss temperatur analyz young adult stage preced h previous determin onset somat report gene express germlin two signific chang observ earli stage first major neuropeptid encod transcript increas total polysom mrna fraction suggest glh effector suppress express second signific decreas major sperm protein msp domain mrnas glh delet find presenc glh help repress spermatogen express oogenesi boost msp express drive spermiogenesi sperm motil insight defin earli role glh repress somat reprogram maintain germlin integr
|
D029742;D009479
|
T123;T116
|
36,273,620
|
kinesin spindl protein inhibitor exacerb cisplatin induc hair cell damag emerg evid indic kinesin famili play vital role influenc growth axon interfer progress tumor howev function kinesin member auditori organ remain unknown sb kinesin spindl protein ksp inhibitor appli mous organ corti hous ear institut organ corti hei oc cell line examin role ksp auditori system without cisplatin damag cell count kit cck lactas dehydrogenas ldh releas assay conduct evalu cell activ toxic pretreat sb increas sensit hei oc cell cisplatin ototox promot cell apoptosi deterior superoxid generat mediat damag cisplatin sb also enhanc cisplatin induc hair cell damag explant mous cochlea vitro furthermor combin n acetylcystein nac treatment cisplatin cisplatin sb complet rescu reduc number hair cell impair cisplatin confirm strengthen function superoxid accumul sb cisplatin treatment inhibit kinesin spindl protein enhanc suscept hair cell cisplatin induc damag mous cochlear explant hei oc cell indic kinesin spindl protein might unpreced target weaken ototox platinum medica
|
D000081015;D000970
|
T121;T047;T046;T109
|
36,273,619
|
valid mapk signal pathway key role paeoniflorin treatment intrahepat cholestasi pregnanc base network pharmacolog metabolom numer studi clarifi effect paeoniflorin treatment cholestasi howev therapeut efficaci mechan action paeoniflorin intrahepat cholestasi pregnanc icp still unknown studi aim investig molecular biolog mechan paeoniflorin icp combin network pharmacolog metabolom effect paeoniflorin investig icp rat model induc ethinylestradiol show improv liver indic liver histopatholog chang bile flow rate serum level tba alp under mechan metabol pathway paeoniflorin reveal network pharmacolog untarget metabolom show paeoniflorin exert curat effect icp induc ferroptosi pikakt mapk signal pathway conclus paeoniflorin protect icp induc liver injuri mapk signal pathway
|
D002780;D011248
|
T047;T046
|
36,273,615
|
joint effect microplast zno nanoparticl life histori paramet rotif abil rotif elimin harm phaeocysti rise concentr microplast nanoparticl coexist simultan marin may bring joint harm zooplankton rotif import function group marin zooplankton play import role energi flow marin ecosystem evalu comprehens effect nano size microplast metal oxid nanoparticl life histori paramet rotif popul dynam rotif elimin harm alga phaeocysti expos rotif brachionus plicatili multipl combin differ concentr nanoplast zno nanoparticl result show rotif matur time prolong total offspr decreas signific rise zno nanoparticl microplast concentr microplast zno nanoparticl signific interact brought serious joint deleteri effect surviv develop reproduct popul level zno nanoparticl exacerb delay effect microplast elimin phaeocysti rotif although eventu rotif also complet elimin phaeocysti close system studi provid new insight reveal comprehens impact microplast zno nanoparticl zooplankton perspect life histori paramet rotif also perspect popul dynam rotif control harm alga great signific understand impact mix pollut marin ecosystem
|
D058087;D015034;D012403;D014874
|
T121;T131;T197;T204;T002
|
36,273,608
|
mno x n dope carbon nanosheet deriv mn mof g c n peroxymonosulf activ electron rich mn center induc n dope fabric metal carbon hybrid heteroatom dope manganes metal organ framework mof rare report peroxymonosulf pms activ work novel mno x n dope carbon mno x nc nanosheet prepar use manganes benzenedicarboxyl acid base mof mn mof differ proport graphit carbon nitrid g c n addit n sourc carbon sourc activ pms sulfamethoxazol smx remov polar differ induc mn n coordin carbon process made c electron poor center mn electron rich center thus provid mn ii pms activ benefit highest mn ii content uniform expos mno x activ site abund n activ speci rich defect site mno x nc show excel degrad within min miner perform within min smx nonrad radic process work togeth mno x nc pmssmx system singlet oxygen domin degrad smx n dope carbon exhibit drag protect effect mno x also provid adsorpt site pms pollut thus reduc migrat distanc moreov electron organ substrat could captur electron poor carbon layer transport electron rich mn center thus improv util effici pms redox mn studi provid facil optim method prepar mof deriv carbon catalyst improv stabil catalyt perform
|
D002244;D000073396
|
T121;T196;T109
|
36,273,607
|
dual layer janus charg nanofiltr membran construct sequenti electrospray polymer effici water soften separ hard ion calcium magnesium hard water improv water qualiti import technic challeng nanofiltr nf attract much attent effici environment friendli low cost howev common nf membran singl either posit negat charg layer insuffici water soften capac work two type dual layer janus charg polyamid nf membran compos opposit charg inner outer layer develop first time sequenti electrospray polymer strategi effici water soften effect microstructur dualli charg barrier layer separ perform dival salt ion explor detail mechanist studi reveal microstructur outer layer barrier layer play crucial role ion separ janus membran due control revers transport ion janus charg polyamid nf membran loos outer layer exhibit better water soften perform hard remov compar singl charg nf membran due simultan dual electrostat effect ion revers transport confin janus charg nf membran also possess good antifoul perform main due negat charg outer layer mechanist insight gain studi reveal huge potenti microstructur design toward high perform janus charg nf membran provid import guidanc futur develop high effici water soften nf membran
|
D009757;D008567
|
T122;T074;T109
|
36,273,593
|
rsc base differenti model correl remov improv multi omic cluster multi omic cluster play import role cancer subtyp howev data differ kind omic often relat correl may reduc cluster algorithm perform crucial elimin unexpect redund inform caus correl differ omic propos rsc base differenti model correl remov improv multi omic cluster rsc mcr method first introduc rsc calcul pairwis correl featur decompos obtain pairwis correl differ omic featur thus built connect differ omic base pairwis correl differ omic featur remov redund correl design differenti model calcul degre differ origin featur matrix correl matrix contain relev inform differ omic compar perform rsc mcr decorrel method differ cluster method cc fcm snf nmf lraclust experiment result five cancer dataset show effici rsc mcr well improv decorrel method
|
D000465;D009369
|
T170;T191
|
36,273,495
|
sarcopenia definit diagnosi treatment consensus grow sarcopenia skelet muscl disord common occur advanc age well number long term condit recognit clinic practic relat recent import associ sarcopenia rang advers effect health includ impair mobil increas morbid mortal origin characteris loss muscl mass definit evolv focus loss skelet muscl function particular strength number intern definit european work group sarcopenia older peopl recent revis progress decad ahead like seen regard use routin health data prescript resist exercis translat biolog epidemiolog first man studi new treatment focus sarcopenia low middl incom countri immedi next step includ newli form global leadership initi sarcopenia develop intern consensus definit diagnosi
|
D055948
|
T047
|
36,273,494
|
smgsmg heterodim loss modul smg kinas drive atr inhibitor resist gastric cancer repres third lead caus global cancer mortal area unmet clinic need drug target dna damag respons includ atr inhibitor atri propos novel target agent gastric cancer sought evalu efficaci atri preclin model gastric cancer understand atri resist might emerg mean identifi predictor atri respons posit select genom wide crispr cas screen identifi candid regul atri resist gastric cancer loss function mutat either smg smg caus atri resist smg mediat mechan although atri still impair atrchk signal smg defect cell characterist respons atri exposur seen chang atmchk hax phospho rpa bp status chang proport cell g phase cell cycl transcriptionrepl conflict trc elicit atri exposur like caus atri sensit smg defect cell exhibit reduc level atri induc trcs could contribut atri resist observ suggest atri elicit antitumor efficaci gastric cancer drug resist could emerg via alter smg pathway
|
D000970;D013274
|
T121;T191;T109
|
36,273,492
|
resist atr inhibitor mediat loss nonsens mediat decay factor upf one million case gastric cancer diagnos year global metastat diseas continu poor prognosi signific proport gastric tumor defect dna damag respons pathway creat therapeut opportun synthet lethal approach sever small molecul inhibitor atr key regul dna damag respons clinic develop target agent gastric cancer perform larg scale crispr interfer screen discov genet determin respons resist atr inhibitor atri gastric cancer cell among top hit identifi mediat atri respons upf compon nonsens mediat decay nmd pathway loss upf caus atri resist across multipl gastric cancer cell line global proteom phosphoproteom transcript profil experi reveal cell cycl progress dna damag respons alter upf mutant cell studi demonstr upf deplet cell fail accumul g follow treatment atri upf loss also reduc transcript replic collis previous associ atri respons therebi suggest possibl mechan resist result uncov novel role nmd factor modul respons atri gastric cancer highlight previous unknown mechan resist may inform clinic use drug
|
D013274
|
T191
|
36,273,481
|
monofila sutur versus braid sutur thread improv pregnanc outcom vagin cervic cerclag c stich pragmat randomis control phase superior trial miscarriag second trimest preterm birth signific global problem vagin cervic cerclag perform prevent pregnanc loss preterm birth aim determin effect monofila sutur thread compar braid sutur thread pregnanc loss rate women undergo cervic cerclag
|
D023802;D047928;D000022
|
T061;T047;T046;T033
|
36,273,456
|
effect thymoquinon oxid stress paramet apolipoprotein e alzheim model rat studi aim investig effect thymoquinon tq oxid stress apolipoprotein e apo experiment alzheim model creat alcl galactos rat
|
D000975;D000544
|
T123;T121;T048;T039;T044;T047
|
36,273,428
|
select inhibit periodont pathogen porphyromona gingivali third generat zafirlukast deriv periodont diseas inflammatori diseas trigger pathogen oral bacteri speci porphyromona gingivali zafirlukast zaf display antibacteri activ p gingivali herein report design synthesi select antibacteri activ novel third generat zaf deriv two second generat zaf deriv test previous test p gingivali atcc third generat deriv display superiorselect antibacteri activ p gingivali compar zaf second generat deriv compound display bactericid activ p gingivali inhibit biofilm growth display hemolyt activ display less cytotox mammalian cell zaf superiorselect antibacteri activ zaf deriv p gingivali increas safeti profil inhibit biofilm growth compar zaf indic compound especi b g show promis antibacteri agent futur studi test potenti prevent treat p gingivali induc periodont diseas
|
D016966;D010510
|
T047;T007
|
36,273,391
|
medic earli treatment covid australia earli treatment sever acut respiratori syndrom coronavirus sar cov infect prevent hospitalis death patient coronavirus diseas covid one risk factor serious covid progress earli treatment present rang logist challeng clinician nevertheless aid grow number approv medic earli treatment covid medic includ drug inhibit sar cov viral replic anti sar cov monoclon antibodi formul provid passiv immunis immunomodulatori drug suppress bodi inflammatori respons sever drug differ mode action approv australia earli treatment covid includ nirmatrelvir plus ritonavir molnupiravir monoclon antibodi formul although drug recommend clinician encourag remain date current indic contraind clinic efficaci drug sar cov variant current circul communiti treatment includ hydroxychloroquin ivermectin dietari supplement popularis recommend earli treatment covid new drug new data use exist approv drug becom avail clinician face grow challeng determin optim treatment array option stand earli treatment covid need individualis depend age pregnanc status exist medic renal liver diseas status futur treatment develop might role patient lower risk profil reduc transmiss learn live sar cov
|
D000086382;D011251
|
T047;T067
|
36,273,385
|
existenti obsess case report postpartum obsess compuls disord existenti obsess eo uncommon type obsess thought also describ philosoph rumin obsess obsess compuls disord ocd postpartum onset clinic pictur frequent count intrus thought infant harm compuls verif
|
D009770;D009771
|
T055;T048
|
36,273,384
|
anti suicid effect lithium infratherapeut dose case report anti suicid effect well document prolong lithium treatment high qualiti evid bipolar disord unipolar depress shown signific superior mood stabil reduct suicid risk
|
D013405;D001714;D003866
|
T033;T048
|
36,273,383
|
variabl associ success group cognit behavior therapi insomnia preliminari result insomnia disord id defin predomin dissatisfact quantiti qualiti sleep associ difficulti initi maintain sleep earli morn awaken inabl go back sleep
|
D007319;D015928
|
T061;T184;T047;T048
|
36,273,382
|
burden satisfact experienc relat patient home hospitalis psychiatri role caregiv essenti home hospit sinc act co therapist level respons experienc higher usual
|
D010549;D011570
|
T033;T097;T091;T041
|
36,273,381
|
implic stigma toward mental health problem suicid risk peopl mental health problem systemat review stigma associ psycholog problem major concern negat affect peopl live differ symptomatolog sometim serious consequ health
|
D001523;D013405
|
T033;T048
|
36,273,380
|
confirmatori factor analysi item toronto alexithymia scale spanish patient substanc use disord alexithymia high preval patient substanc use disord sud impli sud pathogenesi treatment outcom howev psychometr properti use instrument evalu alexithymia item toronto alexithymia scale tas scarc studi relat sud patient
|
D000342;D019966
|
T033;T184;T048
|
36,273,372
|
algebra geometri topolog erk kinet mekerk signal pathway involv cell divis cell specialis surviv cell death shaul seger biochim biophi acta bba mol cell res studi polynomi dynam system describ dynam mekerk propos yeung et al curr biol https doiorgjcub experiment setup data known biolog inform experiment dataset time cours erk measur differ phosphoryl state follow activ either wild type mek mek mutat associ cancer development defect demonstr method comput algebra geometri differenti algebra bayesian statist comput algebra topolog inform model reduct identif paramet infer mek variant respect throughout show algebra viewpoint offer rigor systemat analysi model
|
D008954;D055641
|
T081;T075
|
36,273,358
|
prognosi effect chemotherapi medullari breast carcinoma aim determin prognosi potenti benefit postop chemotherapi accord subtyp medullari breast carcinoma medbc rare invas breast cancer
|
D001943;D018270
|
T191
|
36,273,356
|
masszv haemothorax modern kezels hemothorax umbrella term patholog extrem wide rang etiolog sever common tramuat origin frequent iatrogen intervent blood coagul alter therapi rare unknown depend caus volum dynam requir patient adapt treament determin access certain therapeut method aim provid practic overview
|
D006491;D013898
|
T046;T037
|
36,273,355
|
c reaktvprotein prokalcitoninszintek szrumkinetikja klinikai kimenetellel val kapcsolata kzssgben szerzett szepszisben communiti acquir sepsi life threaten system reaction infect start hour within hospit admitt data concern kinet serum c reactiv protein crp procalcitonin pct level diseas progress spars aim analyz kinet crp pct among adult communiti acquir sepsi
|
D000077740;D018805
|
T123;T047;T046;T116
|
36,273,354
|
panaszment vrandsok artri nyomsrtk vrandssg el msodik trimeszterben cardiovascular system women adapt pregnanc maintain growth fetus
|
D063177;D006973
|
T060;T081;T047
|
36,273,353
|
daganato betegek evidencia alap gondozsi stratgiinak irodalmi ttekints increas proport cancer patient remain perman tumor free primari care due modern curat treatment howev life expect qualiti life deterior signific relaps case spite differ palliat therapi detect earli relaps asymptomat stage patient undergo pre plan care process target primarili improv surviv sever studi review conduct recent decad determin optim ration frequenc method control examin data differ follow strategi analyz sever perspect recommend follow protocol differ signific base origin histolog characterist stage prognost factor typic site recurr local oligometastat system relaps tumor addit detect recurr import qualiti life monitor psycholog status psychosomat complaint well cost effect protocol also came focus involv famili doctor qualifi nurs routin oncolog follow may function altern option reduc workload specialist covid pandem result use telemedicin method evalu examin follow strategi come fore time made evalu control care algorithm even import paper review result studi compar differ follow strategi highlight protocol help optim use health care capac preserv surviv chanc cancer patient relaps orv hetil
|
D011788;D000086382
|
T078;T047;T067
|
36,273,352
|
az autoantitest vizsglatok jelentsg szisztm lupus erythematosusban system lupus erythematosus sle system autoimmun diseas charachter patholog immun complex various autoantibodi detect patholog autoantibodi produc plasma cell differenci b cell play signific role establish clinic diagnosi classif differenti diagnosi well assess diseas activ patient follow autoantibodi determin import risk assess essenti separ subgroup differ risk diseas cours set appropri therapi therapeut goal may possibl assess activ organ involv assess risk threaten event anti sm antiphospholipid antibodi play key role determin common prognost subgroup sle depend risk organ involv associ less common autoantibodi monitor treatment follow may vari review primarili assess diagnost prognost signific autoantibodi common sle orv hetil
|
D000936;D008180
|
T129;T047;T116
|
36,273,347
|
clinic heterogen subject cognit declin data driven approach popul base sampl subject cognit declin scd refer subject experi cognit declin absenc detect cognit impair scd larg studi risk condit cognit declin empir observ suggest person scd heterogen includ individu earli alzheim diseas other psycholog vulner andor physic comorbid semiolog scd still infanc featur predict cognit declin poor defin present studi aim identifi subgroup scd use data driven approach studi clinic evolut across year
|
D000544;D060825
|
T047;T048
|
36,273,346
|
neglect barrier medic use systemat review difficulti associ open medic packag difficulti open medic packag serious consequ lead patient harm via medic mismanag poor adher howev qualiti literatur pertain issu yet collat critiqu systemat review examin cross section studi object examin abil particip open differ medic packag studi identifi met inclus criteria direct observ studi given prior research identifi mismatch self report actual abil score via apprais tool cross section studi reveal methodolog qualiti includ studi typic low studi sampl most consist older adult studi report non neglig proport particip unabl open packag difficulti associ child resist contain sever studi examin associ howev factor consist found signific associ abil open packag despit studi span year packag type examin remain larg suggest despit decad research demonstr packag problemat stagnat medic packag develop whether attribut pauciti high qualiti research therefor lack strong evid chang need unclear futur research strive better methodolog qualiti generalis cohort assess via observ home problem identifi prior research persist may provid impetus chang overdu medic packag industri
|
D004349;D055118
|
T073;T055;T033;T081;T074
|
36,273,345
|
complex implement nationwid advanc care plan program result qualit evalu evalu singapor nation advanc care plan acp program understand challeng implement within multipl clinic set
|
D032722
|
T058
|
36,273,344
|
use recommend summari plan emerg care treatment respect care home qualit interview studi recommend summari plan emerg care treatment respect advanc care plan process design facilit discuss document prefer care medic emerg advanc care plan import residenti nurs home
|
D032722;D004632
|
T061;T058;T093
|
36,273,341
|
hydrolyt stabl cytotox ono n ti iv type octahedr complex new famili titanium iv complex base onon diaminobi phenolato ligand br cl f ortho substitut synthes character x ray structur three deriv reveal homolept l ti type compound exhibit octahedr geometri without bind dangl amin unit dft calcul demonstr prefer l ti complex driven solvent ligand substitut rather entrop effect except fluorin deriv hydrolyz immedi follow water addit room temperatur lowest biolog activ seri test complex show cytotox activ compar higher fold cisplatin toward human ovarian colon ht cancer cell line ic valu incub h activ general higher fold toward sensit ovarian line similar activ complex wherea differ record toward colon line attribut bioavail variat among complex analyz particular high hydrolyt stabil record bromin deriv day ligand hydrolysi room temperatur relat h measur chlorin methyl deriv respect altogeth seri compound repres promis famili anticanc agent chlorin deriv show best combin stabil cytotox bioavail
|
D010051;D000970;D003110;D056831
|
T121;T191;T104;T109
|
36,273,338
|
light activ reactiv oxygen speci respons nanocarri enhanc photodynam immunotherapi cancer explor polymer nanoplatform combin reactiv oxygen speci ros respons mitochondria target emerg effect strategi enhanc photodynam therapi pdt amphiphil copolym synthes react acrylamid thioket tk linker amino termin triphenylphosphonium polyethylen glycol dodecylamin encapsul chlorin e ce via self assembl anion clad tumor target deshel tumor acid microenviron surfac anchor electrostat forc biopegdma rm sequenti target mitochondria cancer cell biopegdma rm could light activ ce releas upon ros cleavag tk linkag found ce load biopegdma rm exhibit higher cytotox ct cell perform stronger abil product ros without tk linker moreov minimum illumin min could requir achiev maximum releas ce high vitro cytotox ce load biopegdma rm respect furthermor ce load biopegdma rm show fold fold higher tumor inhibit balbc nude mice kunm mice stimul immunolog reaction generat ifn tnf activ cd cd cd lymphocyt dcs ce load nanoparticl without tk bond work provid academ refer develop ros respons drug deliveri system advanc pdt effici
|
D011166;D010778;D053758;D009369
|
T061;T123;T073;T109;T191
|
36,273,333
|
natur cation critic affect water negat charg silica interfac understand collect behavior ion charg surfac paramount import geolog electrochem process ion screen surfac charg interfaci field break centro symmetri near surfac probe use second order nonlinear spectroscopi effect electrolyt concentr nonlinear optic respons semi quantit explain mean field model base poisson boltzmann equat yet explain previous report ion specif effect spectroscop respons drastic ion specif chang interfaci properti includ surfac acid dielectr permitt strong ion adsorptiondesorpt invok use sum frequenc generat sfg spectroscopi probe symmetri break water molecul charg silica surfac contact alkalin metal chlorid solut licl nacl kcl cscl various concentr find water respons vari cation sfg respons mark enhanc licl compar cscl show within mean field model neither specif ion surfac interact reduc dielectr constant water near interfac account variat spectral intens cation natur molecular dynam simul confirm decay electrochem potenti weak depend salt type instead effect differ salt optic respons indirect reorgan interfaci water salt type depend align water direct interfac explain observ
|
D012822;D014867
|
T121;T197
|
36,273,308
|
crisprca mediat gene knockout sj schistosoma japonicum egg upregul host egg immun respons schistosomiasi import neglect tropic diseas schistosoma japonicum evad host attack regul host immun caus continu infect howev interact host immun system japonicum unclear previous research found sj protein isol japonicum anti inflammatori effect host howev role sj regul host immun japonicum infect clear appli crisprca techniqu knockout sj japonicum egg investig effect sj regul host immun found egg viabil decreas sj knockout addit found granulomat inflamm increas cell immun respons enhanc immun microenviron chang mice model inject sj knockout egg tail vein find suggest japonicum could regul host immun sj evad host immun attack caus continu infect addit confirm applic crisprca mediat gene reprogram function genom japonicum
|
D012549
|
T204
|
36,273,279
|
contribut communiti health system resili case studi respons drought ethiopia ethiopia exposur el nio drought result high malnutrit intern displac peopl epidem communic diseas strain health system drought especi challeng mother children aim identifi salient factor improv health system resili explor success challeng experienc communiti base health system drought respons
|
D018672;D055864
|
T078;T058;T070;T093
|
36,273,278
|
epidemiolog factor affect outpati depart servic util hospit patient diabet time seri analysi ethiopian hospit burden diabet relat death reach two million global access health care servic adher follow therapi key improv outcom diabet patient aim assess outpati depart opd servic util diabet relat hospit period month
|
D003924;D000086382
|
T047;T067
|
36,273,261
|
year old woman primari biliari cholang crohn ileiti follow suspens ursodeoxychol acid background recogn associ inflammatori bowel diseas ibd hepatobiliari autoimmun diseas particular primari scleros cholang psc fewer report case ibd primari biliari cholang pbc treat ursodeoxychol acid udca report present case year old woman pbc diagnos crohn ileiti suspens udca treatment case report year old femal patient pbc admit depart irrepress chronic diarrhea recurr abdomin pain pbc diagnos basi serolog data chronic month increas alkalin phosphatas alp associ posit specif anti nuclear antibodi sp gp without requir liver biopsi magnet reson cholangiopancreatographi rule psc given intoler non respons accord toronto criteria alp time normal limit year udca mgkgday oral monotherapi treatment use obetichol acid mgday prescrib patient complain abdomin pain upper gastrointestin symptom endoscopichistolog radiolog examin support diagnosi crohn ileiti given potenti benefit pbc patient describ label therapi budesonid dosag mgday po also administ one month discharg improv observ cholestasi indic gastrointestin symptom conclus report present case pbc patient diagnos crohn ileiti cessat treatment udca highlight import recogn associ autoimmun hepatobiliari diseas ibd
|
D008105;D001327;D003424;D015212;D007079
|
T047
|
36,273,260
|
effect superdisintegr disintegr oral disintegr tablet determin simul wet test vitro disintegr test disintegr time critic character oral disintegr tablet odt accord regulatori standard current studi aim assess effect superdisintegr sodium starch glycol croscarmellos sodium crospovidon disintegr odt use simul wet vitro disintegr test result show wet time odt contain sodium starch glycol croscarmellos sodium wet time odt contain crospovidon contrast signific differ vitro disintegr time among odt use differ disintegr ca quick wet time odt crospovidon may attribut strong capillari characterist crospovidon suggest determin disintegr time odt simul wet test insuffici may lead bias result find recommend addit disintegr test imit saliva fluid absorpt tablet break provid precis evalu odt
|
D011205;D002266
|
T121;T122;T109
|
36,273,259
|
associ levothyroxin replac therapi osteoporosi riyadh saudi arabia match case control studi hypothyroid common health problem among elder women howev conflict result observ regard associ levothyroxin treatment osteoporosi risk therefor current studi aim evalu effect levothyroxin replac therapi osteoporosi risk saudi popul studi match case control studi conduct june august data extract electron medic record includ sociodemograph clinic characterist comorbid condit levothyroxin replac therapi dose durat concomit therapi bone miner densiti case match control basi age studi includ case control multivari condit logist regress analysi thyroxin use independ associ increas likelihood osteoporosi therefor levothyroxin use elder femal associ increas risk osteoporosi henc clinician must awar levothyroxin replac therapi outcom postmenopaus femal risk osteoporosi
|
D013974;D010024
|
T121;T116;T109;T125;T047
|
36,273,258
|
new medic base predict score postop delirium surgic patient develop proof feasibl retrospect patient cohort structur risk screen postop delirium pod consid prehospit medic establish aim develop pod risk predict score base known risk factor delirium risk increas drug use pharmacist medic reconcili hospit admiss test feasibl retrospect cohort surgic patient therefor establish pod risk factor drug extract literatur score generat follow score test feasibl retrospect month cohort surgic patient patient higher score suggest higher probabl pod patient chart screen document pod develop score follow pod risk factor defin point assign score calcul age year point year male sex renal insuffici ri hepat impair hi model endstag liver diseas meld delirium risk increas drug point per drug class anticholinerg drug burden acb retrospect test cohort surgic patient factor concern age year patient year male ri meld delirium risk increas drug acb median pod risk predict score rang patient score pod document evid pod data inconclus score pod document patient suffici pod document overal pod document poor summar develop success test feasibl pod predict score assess pharmacist medic reconcili hospit admiss
|
D011183;D003693
|
T046;T048
|
36,273,257
|
effect cyasteron intestin flora braf mutant mous model colorect cancer braf mutat colorect cancer crc aggress respond poor standard treatment studi brafv mutant mice crc treat intragastr cyasteron compound common use tradit chines herbal medicin day microbi dna extract mous intestin content ribosom rna gene amplicon sequenc analyz result indic cyasteron enhanc divers gut microbiota abund benefici bacteria prevotellacea muribaculacea ruminococcacea signific higher cyasteron treat mice control abund erysipelotrichacea famili bacteria promot inflamm gut signific posit correl tumor weight cyasteron potenti inhibitor brafv mutant crc via effect intestin flora
|
D015179;D000069196;D004365
|
T121;T123;T007;T191;T001
|
36,273,256
|
drug induc weight gain last year descript studi medic induc weight gain frustrat patient health care provid drug induc weight gain profound side effect numer common use medic present studi aim investig faer report drug induc weight gain last ten year use us fda advers event report system faer retrospect descript analysi conduct analyz major report advers event weight gain last ten year report submit faer drug induc weight gain common drug report patient associ weight gain risperidon adalimumab pregabalin aripiprazol etanercept prednison conclus present studi show drug induc weight gain common side effect sever medic frequent use treat chronic diseas healthcar provid educ patient medicin may caus weight gain
|
D016907;D064420
|
T170;T037;T046
|
36,273,255
|
evalu impact de escal antimicrobi therapi burn patient retrospect cohort studi antimicrobi use appropri minimis risk resist strain aris associ overus de escal antimicrobi therapi one strategi use ensur appropri use safeti efficaci burn patient unclear aim studi evalu safeti efficaci de escal therapi treat infect burn patient retrospect cohort studi investig patient admit intens care unit burn treat infect octob septemb patient classifi de escal group group compris patient treat empir antimicrobi therapi follow de escal non de escal group group nd compris patient undergo de escal characterist outcom compar group forti three patient met inclus criteria includ patient group patient group nd bacteri speci common detect patient corynebacterium spp pseudomona aeruginosa staphylococcus aureus inter group differ seen day mortal vs p multidrug resist strain detect signific less frequent group group nd p de escal associ use two antimicrobi empir antimicrobi therapi use de escal infect treatment impact day mortal de escal might safe treat infect burn patient
|
D000890;D002056
|
T121;T037
|
36,273,254
|
occurr voriconazol induc cutan squamous cell carcinoma japan data mine differ nation pharmacovigil databas long term voriconazol use may increas risk cutan squamous cell carcinoma cscc especi immunocompromis patient howev relat littl known regard voriconazol induc cscc japan thus purpos studi evalu associ voriconazol use cscc japan use differ nation pharmacovigil databas first use japanes advers drug event report jader databas evalu associ voriconazol use cscc japan second use u food drug administr advers event report system faer databas examin region differ occurr voriconazol induc cscc japan countri calcul report odd ratio ror disproport analysi evalu voriconazol induc cscc studi case one bowen diseas carcinoma situ skin keratoacanthoma squamous cell carcinoma skin squamous cell carcinoma report advers event consid cscc case analysi base jader databas show associ voriconazol use cscc japan ror confid interv analysi base faer databas reveal signal detect japan well western countri australia studi first associ voriconazol use cscc japan assess use nation pharmacovigil databas healthcar provid need fulli awar potenti cscc develop owe voriconazol use countri includ japan ensur care follow patient skin
|
D002294;D012878;D064420
|
T191;T037;T046
|
36,273,251
|
demonstr optic dentin hard measur devic use bovin dentin differ deminer time significanceth increas root cari serious problem societi age root cari diagnos inspect palpat qualit method object quantit evalu progress root cari clinic set strong desir root cari could diagnos measur hard dentin becom softer cari progress vicker hard customarili use indic tooth hard howev method use vivo teeth teeth must dri prior measur make indent hard meter use indent light tooth monitor hamiltom propos optic devic hamiltom could measur hard teeth wet condit dark area appli load dentin without dri therefor hamiltom may realiz hard measur vivo teeth clinic set quantitativelyaimth aim studi demonstr optic dentin hard measur devic hamiltom use bovin dentin differ deminer time evalu correl dark area measur hamiltom vicker hard measur vicker hard testerapproachth sampl bovin dentin deminer lactic acid solut differ time divid group sampl group dark area vicker hard measur sampl group use obtain calibr curv calcul vicker hard dark area group use valid calibr curv obtain dentin sampl group resultsth area appear black without total intern reflect indent measur hamiltom increas deminer time increas addit vicker hard group calcul dark area group calibr curv obtain group vicker hard group measur vicker hard tester strong correl determin coeffici conclusionsth result demonstr hamiltom may suitabl altern convent method unlik convent method use vivo teeth hamiltom hold potenti quantit evalu progress cari vivo teeth
|
D017213;D055096;D017001;D003731
|
T033;T047;T073
|
36,273,250
|
high accur autom quantif dd orient cerebrovasculatur use window optim method significancedeep imag cerebr vessel accur organiz character vital understand relationship tissu structur functionaimw aim larg depth imag mous brain vessel base aggreg induc emiss luminogen aiegen creat new algorithm character spatial orient adapt superior accuracyapproachassist aiegen near infrar ii excit three photon fluoresc pf imag larg depth cerebr blood vessel captur window optim wo method develop high accur autom dd orient determin applic system demonstr establish orient architectur mous cerebrovasculatur millimet level depthresultsth wo method prove signific higher accuraci case method fix window size depth diamet depend orient inform acquir base vivo pf imag wo analysi cerebr vessel imag penetr depth miceconclusionsw built imag analysi system cerebrovasculatur conduc applic neurosci clinic field
|
D017785;D003952
|
T060;T167
|
36,273,244
|
relat letter word sentenc level process read much prior research read focus specif level process often letter word sentenc first time adult reader provid combin investig three key compon process read comprehens test group particip three task thought reflect process level alphabet decis lexic decis grammat decis particip also perform non read classif task aim partial common binari decis process correl across three main task examin pairwis partial correl respons time rts three read task result reveal strong signific correl across adjac level process ie letter word word sentenc non signific correl non adjac level letter sentenc result provid import new benchmark evalu comput model describ letter word sentenc contribut read comprehens
|
D007802
|
T171
|
36,273,243
|
sub terahertz silicon base chip absorpt spectroscopi use thin film model biolog applic spectroscopi sub terahertz sub thz rang frequenc util studi picosecond dynam interact biomolecul howev wide use free space thz spectromet typic limit function due low signal nois ratio complex setup chip spectromet revolution thz spectroscopi allow integr compact low cost fabric paper low loss silicon base platform propos chip sub thz spectroscopi function silicon chip immobil bio particl demonstr abil character low loss nano scale biomolecul across g band thz also introduc electromagnet thin film model account load effect immobil biomolecul ie dehydr streptavidin immunoglobulin antibodi two key molecul biosens disciplin propos platform fabric use singl mask micro fabric process measur vector network analyz vna offer high dynam rang high spectral resolut measur propos planar platform general pave way toward low loss cost effect integr sub thz biosensor detect character biomolecul
|
D012825;D055068
|
T196;T059
|
36,273,240
|
semi supervis adapt markov gaussian embed process samgep predict phenotyp event time use electron health record exist numer method identifi binari phenotyp ie copd use electron health record ehr data exist ascertain time phenotyp event ie copd onset exacerb estim event time could enabl power use ehr data longitudin risk model includ surviv analysi introduc semi supervis adapt markov gaussian embed process samgep semi supervis machin learn algorithm estim phenotyp event time use ehr data limit observ label requir resourc intens chart review obtain samgep model latent phenotyp state binari markov process employ adapt weight strategi map timestamp ehr featur embed function model state depend gaussian process samgep featur weight achiev meaning featur select predict signific improv auc f score exist approach divers simul real world set particular adept predict cumul risk event count process function robust divers generat model paramet moreov achiev high accuraci label effici leverag unlabel ehr data maxim inform gain cost obtain event time label samgep use estim accur phenotyp state function risk model research
|
D057286;D029424
|
T047;T170;T073
|
36,273,239
|
character bind mrtx avenu discoveri potenti kras gd inhibitor cancer therapi kirsten rat sarcoma kras oncoprotein drug hunter list decad initi consid undrugg recent advanc success broken jinx coval inhibit exploit mutat cys switch ii bind pocket kras gc though approach achiev level success patient mutat cys still uncat kras gd frequent kras mutat oncoprotein recent mrtx discov potenti inhibitor kras gd studi seek unravel structur bind mechan mrtx well identifi potenti drug lead kras gd base structur bind characterist mrtx reveal mrtx bind stabil bind site increas hydrophob result induc posit correl movement switch ii could disrupt interact effector regulatori protein furthermor mrtx interact critic residu asp kcalmol kcalmol met kcalmol thr kcalmol gln kcalmol arg kcalmol tyr kcalmol tyr kcalmol gli kcalmol asp kcalmol val kcalmol contribut signific total free bind energi kcalmol pharmacophor base virtual screen base structur bind mechan mrtx identifi zinc zinc zinc potenti kras gd inhibitor structur optimis biochem test compound would assist discoveri effect kras gd inhibitor
|
D016283;D009369
|
T191;T126;T116
|
36,273,238
|
pre diabet glycemia daili glucos variabl associ retin nerv fiber layer thick maastricht studi retinopathi neuropathi type diabet preced retin nerv fibr layer rnfl thin index neurodegener investig whether glucos metabol status gms measur glycaemia daili glucos variabl gv associ rnfl thick entir rang glucos toler use cross section data maastricht studi particip men mean age year type diabet investig associ gms measur glycaemia fast plasma glucos fpg h post load glucos h pg hbac advanc glycat endproduct age assess skin autofluoresc saf indic daili gv increment glucos peak igp continu glucos monitor cgm assess standard deviat sd mean rnfl thick use linear regress analys gms p trend analys adjust associ demograph cardiovascular risk lifestyl factor measur gv indic mean glycaemia full adjust type diabet prediabet versus normal glucos metabol associ lower rnfl thick standard beta ci respect p trend greater fpg h pg hbac saf igp cgm assess sd also associ lower rnfl thick per sd respect popul base studi advers gms entir rang glucos toler greater glycaemia daili gv associ lower rnfl thick henc earli identif individu hyperglycaemia earli glucos lower treatment earli monitor daili gv may contribut prevent rnfl thin index neurodegener precursor retinopathi neuropathi
|
D011236;D003924;D012164
|
T047
|
36,273,237
|
rela requir cd express stem like characterist hypopharyng cancer cd also refer nerv growth factor receptor p ntr express cancer stem cell hypopharyng cancer hpc regul cell prolifer elev express cd increas cancer malign correl poor prognosi cd could promis therapeut target howev littl known induct cd express especi promot activ studi screen transcript factor found rela p subunit nuclear factor kappab nf b critic cd transcript cancer cell specif found rela promot cd transcript squamous cell carcinoma cell line normal epithelium neuroblastoma cell line within cd promot sequenc region import rela bind cell harbor delet proxim region decreas cd express sphere format activ addit found clinic tissu sampl show elev cd express enrich rela bind site hpc tissu show elev level cd phosphoryl rela data suggest rela increas cd express inhibit rela bind cd promot could effect therapeut target
|
D007012
|
T191
|
36,273,235
|
investig turn point effect covid social distanc covid first digit document pandem histori present uniqu opportun learn best deal similar crise futur studi carri model base evalu effect social distanc use austria slovenia exampl wherea major compar studi postul negat relationship stringenc social distanc reduct social contact scale epidem model suggest vari relationship turn point system chang predomin regim less social distanc cumul death infect less social distanc fewer cumul death infect relationship found persist scenario distinct season variat transmiss limit nation intens care capabl situat relax social distanc low transmiss season spring summer found reliev pressur high transmiss season fall winter thus reduc total number infect fatal strategi take account relationship could particular benefici situat long term contain feasibl
|
D000085762;D000086382
|
T047;T067;T054
|
36,273,234
|
geometr learn function brain network correl manifold correl matrix typic represent node interact function brain network analysi analysi correl matrix character brain network observ sever neuroimag modal conduct predomin euclidean space assum pairwis interact mutual independ one way take account interact network whole analyz correl matrix geometr structur recent studi focus space correl matric strict subset symmetr posit definit spd matric form uniqu mathemat structur known riemannian manifold howev mathemat oper correl matrix spd geometri may necessarili coher ie structur correl matrix may preserv necessit post hoc normal contribut current paper twofold devis set inferenti method correl manifold demonstr applic function network analysi present sever algorithm correl manifold includ measur central tendenc cluster analysi hypothesi test low dimension embed simul real data analysi support applic propos framework brain network analysi
|
D000465;D001921
|
T023;T170
|
36,273,233
|
circrna express profil breast cancer construct circrna mirna mrna network circrna group endogen small noncod rnas involv multipl diseas includ cancer present function circrna breast cancer need explor studi pair breast cancer paracanc tissu axillari lymph node metastasi collect circrna high throughput sequenc identifi distinct circrna candid signific differenti express found circrna breast cancer tissu relat match paracanc tissu aslo identifi differenti express mirna mrnas breast cancer tissu normal breast tissu public databas construct regulatori cerna network mrnas associ prognosi breast cancer also construct circrna mediat subnetwork might relat prognosi breast cancer articl provid better understand circrna mediat cerna regulatori network circrna compet endogen rnas breast cancer
|
D035683;D001943
|
T123;T191;T114
|
36,273,232
|
person ctdna micro panel monitor predict clinic outcom patient tripl negat breast cancer circul tumor dna ctdna peripher blood use predict prognosi therapeut respons tripl negat breast cancer tnbc patient howev previous approach typic use larg comprehens panel gene common mutat across breast cancer given reduct sequenc cost decreas turnaround time associ panel generat object studi assess use custom micro panel track diseas predict clinic outcom patient tnbc pair tumor normal sampl patient tnbc obtain diagnosi whole exom sequenc wes perform identifi somat variant associ individu tumor custom micro panel variant creat individu enrol studi peripher blood obtain baselin cycl day time surgeri month interv surgeri assess variant allel fraction vaf differ timepoint diseas cours vaf compar clinic outcom evalu abil custom micro panel predict patholog respons diseas free interv patient relaps cohort individu evalu month post diagnosi tnbc total patient achiev patholog complet respons pcr seven patient develop clinic relaps patient develop clinic relaps peripher blood obtain month prior relaps n custom ctdna micro panel identifi molecular relaps averag month prior clinic relaps custom ctdna panel result moder associ pcr diseas monitor patient pcr molecular relaps wherea patient without pcr molecular relaps chi squar p valu studi show custom micro panel marker effect use predict outcom monitor remiss patient tnbc custom micro panel show high sensit detect molecular relaps advanc clinic relaps use panel could improv patient outcom earli detect relaps preemptiv intervent prior symptom onset
|
D000074141;D064726
|
T191;T114
|
36,273,231
|
high effici hybridoma generat screen strategi anti pd monoclon antibodi develop program cell death protein pd play signific role suppress antitumor immun respons cancer treatment immun checkpoint inhibitor ici target pd approv treat numer cancer backbon cancer immunotherapi anti pd molecul necessari next generat cancer immunotherapi improv clinic efficaci safeti well integr novel treatment combin platform develop high effici hybridoma generat screen strategi generat high potenc chimer anti pd molecul use strategi success generat sever mous hybridoma mousehuman chimer clone produc high affin antibodi human pd high qualiti vitro pd pd l bind blockad cell activ activ lead chimer prototyp exhibit overal vitro perform compar commerci avail anti pd antibodi could qualifi promis therapeut candid develop toward immuno oncolog applic
|
D061026;D009369
|
T129;T191;T116;T192
|
36,273,230
|
epigenet control chromosom associ lncrna gene essenti replic stabil asar long noncod rna gene control replic time entir human chromosom cis three known asar gene locat human chromosom essenti chromosom integr identifi asar human chromosom util set distinct asar characterist allow identif hundr autosom loci epigenet control allel restrict behavior express replic time code noncod gene distinct genom imprint disrupt noncod rna gene five five test loci result chromosom wide delay replic chromosom instabl valid asar activ addit three known essenti cis act chromosom loci origin centromer telomer propos mammalian chromosom also contain inactivationst center display allel restrict epigenet regul protein code noncod asar gene essenti replic stabil chromosom
|
D062085
|
T123;T114
|
36,273,229
|
reward salienc spatial attent domin valu represent orbitofront cortex orbitofront cortex ofc encod valu play key role valu base decis make howev attent modul ofc valu encod poor understood train two monkey detect lumin chang cu locat pair visual stimuli train pictur associ differ amount juic reward thus differ reward salienc monkey behavior dorsolater prefront cortex neuron activ indic monkey activ direct spatial attent toward cu stimulus task howev ofc neuron respons domin stimulus higher reward salienc encod valu valu less salient stimulus weak repres regardless spatial attent result demonstr reward spatial attent distinct repres prefront cortex ofc maintain stabl represent reward salienc minim affect attent
|
D012201;D017397
|
T023;T029;T041;T030
|
36,273,220
|
mesenchym stem cell aggreg mediat integrin vcam intrathec transplant mcao rat mesenchym stem cell mscs shown immens therapeut potenti various brain diseas intrathec administr mscs may enhanc recruit lesion central nervous system impact cerebrospin fluid csf flow remain unclear
|
D020244;D039441;D045164;D059630;D019010
|
T061;T129;T116;T025;T192;T020;T047
|
36,273,219
|
plasma proteom profil identifi chang associ ad ftd frontotempor dementia ftd caus frontotempor lobar degener ftld character main inclus tau ftld tau tar dna bind ftld tdp protein plasma biomark strong need specif diagnosi potenti treatment monitor ftd aim identifi specif ftd plasma biomark profil discrimin ftd ad control ftd patholog subtyp addit compar plasma result result post mortem frontal cortex ftd case understand under process
|
D057180;D057174;D020774
|
T047;T048
|
36,273,218
|
effect vitamin supplement brain wave behavior perform nitric oxid malondialdehyd high sensit c reactiv protein children attent deficithyperact disord studi protocol random clinic trial attent deficithyperact disord adhd common chronic mental behavior disord among children studi show lower level vitamin patient adhd compar healthi peopl clinic trial conduct field present studi perform examin effect vitamin supplement children adhd
|
D001289;D019587;D014807
|
T061;T121;T127;T168;T048
|
36,273,217
|
effect exosom deriv trichinella spirali infect larva intestin epitheli barrier function muscl larva trichinella spirali parasit host intestin epithelium mechan exosom particip invas spirali muscl larva unclear henc purpos studi explor effect exosom deriv spirali infect larva tsexo barrier function porcin small intestin epitheli cell ipec j first tsexo success obtain ingest epitheli cell valid furthermor optim induct condit determin cck kit found exposur gml tsexo h decreas viabil ipec j cell base outcom effect tsexo cell biolog process tight junction studi coincub tsexo ipec j cell result show signific increas content fitc dextran level lactat dehydrogenas ldh reactiv oxygen speci ros rate apoptosi increas nuclear pyknosi nuclear ruptur observ cell induc tsexo express il upregul express il tgf tlr muc muc downregul tsexo induct also led decreas level zo cldn ocln conclus tsexo involv sever cellular biolog process function disrupt physiolog biochem process hyperactiv innat immun damag tight junction
|
D017160;D055354
|
T026;T204
|
36,273,216
|
enrich enrol random doubl blind placebo control cross trial phenytoin cream pain chronic idiopath axon polyneuropathi ephen studi protocol patient chronic idiopath axon polyneuropathi ciap neuropath pain signific impact qualiti life oral neuropath pain medic often insuffici pain relief side effect topic phenytoin cream could circumv limit primari object trial evalu efficaci pain reduct safeti phenytoin cream patient pain ciap main secondari object explor use doubl blind placebo control respons test dobret identifi respond sustain pain relief phenytoin cream
|
D009437;D011115
|
T184;T047
|
36,273,214
|
risk transmiss foot mouth diseas wild anim infect dynam japanes wild boar follow direct inocul contact exposur understand diseas dynam viral shed wild boar potenti diseas spread within wild boar domest pig popul critic develop effect control erad measur foot mouth diseas fmd accord infect experiment wild boar domest pig fmd virus fmdv strain otai amog studi suscept viral transmiss popul similar fmdv infect pig wild boar inocul virus exhibit vesicular lesion feet snout tongu lip although show lame inocul wild boar equal capabl transmit virus contact anim contact pig develop vesicular lesion contact inocul anim contrast wild boar expos infect anim show obvious clinic sign result use understand critic role occur sustain fmd outbreak use establish epidemiolog surveil program effect countermeasur wild boar
|
D005536;D029544;D013553
|
T047;T005
|
36,273,213
|
assess perform key indic one health evid base one health index zoonos sub saharan africa zoonos public health threat caus sever damag worldwid zoonos constitut key indic one health oh oh approach appli zoonosi control programm zoonot diseas recent studi develop evalu system oh perform global oh index gohi studi appli gohi evalu oh perform zoonos sub saharan africa
|
D000074823
|
T078
|
36,273,212
|
synergist effect silybin curcumin virul carbapenemas gene express multidrug resist klebsiella oxytoca silybin curcumin potenti antimicrobi effect studi aim evalu synergist antimicrobi effect silybin curcumin virul carbapenemas gene express among multidrug resist mdr klebsiella oxytoca
|
D041121;D003474
|
T121;T007;T130;T109
|
36,273,211
|
diagnost reliabl serum activ b holo transcobalamin true evalu vitamin b defici relev current perspect measur total vitamin b vit b concentr rais concern earli detect vit b defici due clinic unreli present articl aim assess efficaci holo transcobolamin activ vit b true evalu vit b defici
|
D014155;D014806
|
T123;T047;T116
|
36,273,210
|
home base intens treatment chronic radiat associ dysphagia head neck cancer survivor hit crad trial chronic radiat associ dysphagia c rad consid one sever function impair head neck cancer survivor treat radiat rt chemoradi crt given major impact late toxic patient health qualiti life strong need evid base dysphagia manag although studi report benefit strengthen exercis transfer chang muscl strength chang swallow function often remain limit therefor combin isol strengthen exercis function train patient c rad may lead greater function gain
|
D003680;D006258
|
T047;T191
|
36,273,209
|
feasibl point care test prevent manag breast cancer therapi associ comorbid african countri short communic obes mediat inflamm identifi import risk predict factor postmenopaus breast cancer bc survivor use aromatas inhibitor ai studi conduct assess impact point care technolog pcot part patholog support genet test psgt prevent bc therapi associ comorbid african set
|
D047072;D001943
|
T121;T191
|
36,273,208
|
compar sensit social media data accept use research social media data offer rich resourc research interest public health labor econom polit social behavior topic howev scale anonym mean research often direct get permiss user collect analyz social media data articl appli basic ethic principl respect person consid individu percept accept use data compar individu percept accept use type sensit data health record individu identifi percept accept use social media data survey peopl show individu think social media data moder sensit agre protect respond general okay research use data social research prefer research clear articul benefit seek explicit consent conduct research argu research must ensur research provid social benefit worthi individu risk must address risk throughout research process
|
D061108
|
T170
|
36,273,204
|
layer specif retinotop diffus modul human visual cortex respons view emot express face view face perceiv emot express evok enhanc neural respons multipl brain region phenomenon thought depend critic amygdala emot relat modul evid even primari visual cortex v provid potenti neural substrat emot salient stimuli affect percept emot valenc inform comput amygdala reach v use high resolut function mri investig layer profil retinotop distribut neural activ specif emot facial express across three experi human particip view central present face stimuli vari emot express perform gender judgment task found facial valenc sensit evid superfici cortic layer restrict retinotop locat stimuli consist diffus feedback like project amygdala togeth result provid feedback mechan amygdala direct modul activ earliest stage visual process
|
D005149;D014793
|
T033;T023;T029
|
36,273,203
|
use real time risk predict model identifi pediatr patient risk thromboembol event studi protocol children likelihood thrombosi clot trial pediatr patient increas rate hospit associ venous thromboembol ha vte sever risk predict model develop design assess general pediatr patient none shown improv patient outcom implement routin clinic care
|
D013927;D054556
|
T047;T046
|
36,273,202
|
analges efficaci safeti nalbuphin versus morphin periop tumor ablat random control multicent trial studi compar efficaci safeti nalbuphin hydrochlorid inject morphin hydrochlorid inject periop analgesia tumor ablat differ two group regard durat surgeri averag daili dose patient satisfact analgesia qualiti life indic furthermor evalu clinic applic nalbuphin morphin periop analgesia ablat surgeri provid import refer guidanc clinic practic
|
D009266;D009369
|
T121;T191;T109
|
36,273,201
|
biallel mutat ttc ttcb identifi chines patient multisystem ciliopathi syndrom abnorm cilia ultrastructur function lead rang human phenotyp term ciliopathi mani tetratricopeptid repeat domain ttc famili member report play critic role cilium organ function
|
D000072661;D004398
|
T019;T116;T126;T123
|
36,273,200
|
quantit paramet dynam contrast enhanc magnet reson imag predict lymphovascular invas surviv outcom breast cancer lymphovascular invas lvi predict poor outcom breast cancer bc lvi postop diagnos histopatholog aim determin whether quantit paramet dynam contrast enhanc magnet reson imag dce mri preoper predict lvi clinic outcom bc patient
|
D001943
|
T191
|
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