PMID
int64 35.7M
36.4M
| Title/Abstract
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36,271,206
|
risk advers outcom inflammatori bowel diseas patient infect sar cov systemat review meta analysi peopl without inflammatori bowel diseas ibd statist signific differ probabl contract sever acut respiratori syndrom coronavirus sar cov howev risk advers outcom ibd patient virus infect remain unclear
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D000086382;D015212;D003093
|
T047;T067
|
36,271,196
|
nitric oxid allevi salt stress protein nitrosyl transcript regul tomato seedl enhanc resist tomato seedl salt stress protein nitrosyl transcript regul involv regul mapk signal carbohydr metabol nitric oxid regul various physiolog biochem process stress respons plant found nitrosoglutathion gsno treatment signific promot growth tomato seedl nacl stress indic play posit role salt stress resist moreov gsno pretreat result increas endogen level nitrosothiol sno content nitrosoglutathion reductas gsnor activ gsnor express salt stress implic nitrosyl might involv allevi salt stress explor whether nitrosyl key molecular mechan allevi salt stress biotin switch techniqu liquid chromatographymass spectrometrymass spectrometri lc msms conduct total putat nitrosyl protein identifi main enrich chloroplast cytoplasm mitochondrion among nitrosyl protein involv mitogen activ protein kinas mapk signal transduct carbohydr metabol respect mapk signal various nitrosyl protein sam sam sam ppc snrk regul mapk mapkk mapkk regul transcript level gsno treatment salt stress compar nacl treatment alon gsno pretreat could reduc ethylen product aba content nacl stress addit activ enzym identifi carbohydr metabol express transcript level metabolit content regul gsno supplic salt stress result activ glycolysi tricarboxyl acid cycl tca cycl thus result demonstr might benefici regul mapk signal transcript level activ carbohydr metabol post translat transcript level protect seedl energi defici salin therebi allevi salt stress induc damag tomato seedl provid initi insight regulatori mechan respons salt stress
|
D018551;D026403
|
T121;T123;T109;T168;T002
|
36,271,172
|
silenc egfr upregul express cd cd activ complement system sensit lung cancer checkpoint blockad complement system critic immun compon yet role tumor immun evas cd cell activ clear defin demonstr epiderm growth factor receptor egfr wnt signal induc catenin mediat long noncod rna lncrna linc express spong cd target mir b cd target mir consequ upregul cdcd express suppress complement system cytokin secret requir cd cell activ cdcd neutral antibodi treatment mutat linc promot activ complement cd cell inhibit tumor growth import combin anti cdcd anti program death anti pd antibodi treatment elicit synergist tumor inhibit effect addit cdcd level invers correl infiltr macrophag cd cell human lung cancer specimen predict patient outcom find underscor critic role egfrwnt catenin upregul cdcd express inhibit complement cd cell activ tumor immun evas immun checkpoint blockad resist identifi potenti combin therapi overcom effect
|
D062085;D008175;D035683
|
T123;T191;T114
|
36,271,163
|
mobil trace element sediment lake hawassa koka ziway ethiopian rift valley present work focus total concentr trace element chromium cr manganes mn cobalt co nickel ni copper cu zinc zn arsenic selenium se cadmium cd lead pb oper defin speciat surfac sediment three ethiopian rift valley lake hawassa koka ziway total concentr determin use induct coupl plasma mass spectromet icp ms six step sequenti extract also appli evalu mobil potenti element compar consensus base sediment qualiti guidelin sqgs develop freshwat ecosystem total zn concentr sediment lake hawassa ziway well cr ni zn sediment lake koka higher probabl effect concentr pec suggest element could negat effect benthic organ sequenti extract result show cd mn se certain extent associ revers fraction f f sediment therebi mobil investig trace element predict mobil trace element use distribut coeffici k valu also agreement sequenti extract result furthermor multivari statist analys show redox sensit fraction f f residu fraction f domin factor control trace element mobil final appli risk assess code rac classif system result show mn lake koka could pose high risk cd mn lake hawassa well cd mn se lake ziway sediment could pose medium risk benthic organ
|
D014131;D019216;D001151;D012643;D014874
|
T123;T196;T121;T131
|
36,271,143
|
adapt host cell environ experiment evolut zika virus zika virus zikv infect caus import development neurolog defect human type iiii interferon respons control zikv infect patholog process yet virus evolv various mechan defeat host respons establish pipelin delin high resolut genet evolut zikv control host cell environ uncov serial passag zikv acquir increas infect simultan develop resist tlr induc restrict built mathemat model suggest increas infect due reduc time lag infect viral replic found adapt cell type specif suggest differ cell environ may drive viral evolut along differ rout deep sequenc zikv popul pinpoint mutat whose increas frequenc tempor coincid acquisit adapt phenotyp function valid sl substitut zikv envelop e protein recapitul adapt phenotyp posit e structur suggest putat function protein refoldingst taken togeth result uncov zikv adapt cellular environ lead acceler replic onset coupl resist tlr induc antivir respons work provid insight zika virus adapt host cell immun escap mechan
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D000071244;D000071243
|
T005;T047
|
36,271,137
|
comparison art outcom patient poor ovarian respons accord poseidon criteria aim studi evalu whether patient orient strategi encompass individu oocyt number poseidon criteria reflect prognosi control ovarian stimul cos compar result assist reproduct technolog art four poseidon normal respond nr group total patient includ retrospect observ studi patient underw various cos protocol vitro fertil intracytoplasm sperm inject follow fresh frozen embryo transfer base clinic demograph data patient divid four group accord poseidon classif art outcom evalu statist analys perform use r version p valu consid signific nr group highest number total oocyt retriev total embryo obtain well best art outcom term clinic pregnanc rate cpr poseidon group better cos art outcom group cpr group respect patient group younger group definit cpr lower patient group compar young old women low anti mllerian hormon amh level younger group poseidon group better cos art outcom older counterpart especi poseidon group binari logist regress adjust bodi mass index bmi compar art outcom patient get pregnant poseidon group compar nr group show odd ratio or confid interv group respect ovarian reserv still seem outweigh patient age predict art outcom low respond infertil women suggest result poseidon group howev differ ovarian reserv poseidon group younger women low amh higher probabl pregnanc amh match older counterpart
|
D007247;D065851
|
T033;T047;T046;T042
|
36,271,136
|
effect covid vaccin healthcar worker shiga prefectur japan studi includ serolog cellular immun test evalu whether coronavirus diseas covid vaccin adequ protect healthcar worker hcws covid serolog investig conduct among hcws mean standard deviat month last covid vaccin anti sar cov antibodi n ig spike ig roch n igg spike igm igg abbott evalu use questionnair health condit hcws analyz cellular immun use spot sar cov kit hcws follow day third vaccin spike igg valu auml forti nine hcws pre exist sar cov infect none infecti seroposit hcws requir hospit spot valu sfu cell third vaccin increas sfu cell immedi attenu later sfu cell poor count sfu cell present hcws third vaccin respect find provid insight humor cellular immun respons repeat covid vaccin covid vaccin effect protect hcws serious ill origin wuhan alpha delta also ongo omicron predomin period howev repeat vaccin use current vaccin version may induc suffici cellular immun hcws
|
D000086382
|
T047;T067
|
36,271,135
|
urin stabil normal strategi favor unbias analysi urinari ev content urin featur ideal sourc non invas diagnost marker intrins methodolog issu still pose barrier full potenti liquid biopsi substrat unlik blood urin concentr vari nutrit hydrat environment factor urin enrich ev urinari genit tract conserv purif normal introduc bias analysi ev subset inter intra individu comparison present studi evalu method decreas bias appropri feasibl urin storag optim singl step ev purif method recoveri protein rnas small urin volum normal method quantit analysi urin ev rnas ultracentrifug chemic precipit immuno affin use isol ev healthi donor urin store frozen room temperatur month multipl urin biochem ev paramet includ particl count protein content compar across urin sampl purpos nanoparticl track analysi nta protein assess bca elisa wb assay perform measur correl relat abund select ev mrnas mirna assess rt pcr rank abil reflect correct ev content variat longitudin urin sampl purif method enabl recoveri downstream analysi ev ml urin find highlight long term stabil ev rnas upon urin storag rt well excel correl ev content urin routin measur biochem featur total urin protein albumin creatinin convent use urin normal compar evalu mrna mirna ev isol reveal specif rnas particular rni small mirna panel level well reflect inter sampl ev variat therefor use possibl post analyt normal ev rna content describ realist urin process normal solut unbias readout ev biomark studi routin clinic sampl diagnost provid input design larger valid studi employ urin ev biomark particular condit diseas
|
D000067128;D035683
|
T026;T123;T114
|
36,271,134
|
paleo perspect west antarct ice sheet retreat geolog record ice sheet collaps provid perspect ongo retreat ground float ice abrupt retreat west antarct ice sheet wai occur earli deglaci well record eastern ross sea continent shelf ice shelf breakup cal calibr kyr bp caus acceler ice mass loss bindschadl ice stream bis acceler mass loss led signific negat mass balanc organ wai flow across central eastern ross sea cal kyr bp dynam thin ground ice trigger retreat open km ground line embay whale deep basin wdb middl continent shelf reconstruct pattern durat rate retreat backstep success small scale ground zone ridg form embay eastern flank use two end member paleo sediment flux ie accumul rate convert cumul sediment volum ridg field elaps time measur distanc ground line retreat end member flux correspond deposit rate buttress unbuttress ice stream flow scenario requir sustain rapid retreat exceed sever centuri ground line retreat estim averag evid favor latter scenario iceberg furrow cross cut ridg deep water requir weak buttress flow embay open comparison modern ground zone dynam paleo perspect provid confid model project larg scale sustain contract ground ice underway sever pacif ocean sector wai
|
D046448;D057232
|
T070;T069
|
36,271,133
|
refin stress gradient hypothesi mix speci group african mammal speci interact facilit predat influenc food web yet unclear mediat environment gradient test stress gradient hypothesi predict posit speci interact increas stress draw upon spatial explicit data larg mammal african savanna test predat risk primari product mediat occurr mix speci group control habitat structur predat risk lion primari product affect frequenc mix speci group speci specif way like reflect distinct stress percept test whether mix speci group indic posit interact conduct network analys specif scenario predat risk dyadic associ giraff pronounc metric anim network chang mark howev dyadic associ network metric weak mediat primari product composit mix speci group associ similar prey suscept similar feed habit herbivor especi predat risk favour frequenc mix speci group pronounc dyadic associ dilut predat risk increas predat detect result provid support stress gradient hypothesi also highlight relat import stressor context depend
|
D020387;D008045
|
T070;T015
|
36,271,132
|
self report visual impair sarcopenia among older peopl cameroon age clear associ declin visual physic perform alter visual function associ negat health outcom includ physic frailti assess relationship visual impair vi sarcopenia older person cameroon cross section survey conduct douala sarcopenia assess use sppb short physic perform batteri test score diagnosi sarcopenia base sppb test score vi self report particip male mean age year report vi preval sarcopenia ci adjust sever factor vi signific associ sarcopenia ci sppb subtest chair stand test negat associ vi ci studi support associ vi sarcopenia confirm cohort studi result would suggest vi could consid earli indic sarcopenia among older peopl sub saharan africa
|
D055948;D015354
|
T047
|
36,271,128
|
interim fdg petct therapi monitor prognost hodgkin lymphoma aim studi assess predict valu interim fdg petct ipet patient hodgkin lymphoma hl treat adriamycin bleomycin vinblastin dacarbazin abvd chemotherapi total consecut patient de novo hl evalu retrospect patient treat upfront abvd perform petct scan baselin cycl interim pet ipet cycl ipet end therapi follow least month therapi respons status ipet defin accord standard five point deauvill score ds follow complet metabol respons cmr ds non complet metabol respons ncmr ds end treatment eot respons assess fdg petct need biopsi confirm pet posit find associ ipet eot respons investig use logist regress analysi surviv analysi perform use cox regress hazard model kaplan meier method sixti nine patient underw ipet ipet associ found time ipet ipet respons status p valu two hundr one patient ipet cmr ipet ncmr ipet strong associ eot respons status ipet cmr complet respons eot patient ipet ncmr present complet respons eot p valu median follow month rang patient ipet cmr present better outcom event free surviv ef overal surviv os ipet ncmr respect p valu multivari analys ipet retain independ prognost factor ef os p valu p valu respect ipet high predict outcom hl patient treat abvd allow tailor therapi individu patient
|
D006689
|
T191
|
36,271,127
|
biosensor base novel nonlinear delta function photon crystal compris weak nonlinear research propos novel nonlinear delta function photon crystal detect sodium iodid nai solut differ concentr suggest structur compris delta stack gap aqueous solut nai stack consid weak defocus nonlinear order vm due nonlinear design defect like reson form within photon band gap thus detect nai differ concentr easili investig without inclus defect photon crystal structur effect linear part refract index gap layer nonlinear coeffici transmitt valu thorough discuss numer find investig reson peak begin split critic nonlinear propos structur split occur vm regard suggest sensor provid high sensit nmriu wonder detect limit
|
D012974;D015374
|
T121;T075;T197;T059;T130
|
36,271,126
|
advers event profil microscop coliti japanes advers drug event report jader databas microscop coliti mc chronic inflammatori bowel diseas character nonbloodi wateri diarrhea epidemiolog japan differ europ unit state littl inform avail epidemiolog survey mc japan studi aim provid new hypothesi regard factor associ mc use japanes advers drug event report jader databas coliti microscop prefer term code case enter jader databas analyz case jader databas case observ associ mc weibul analysi reveal median onset durat mc interquartil rang day lansoprazol user day aspirin user multipl logist regress analysi reveal mc signific associ femal sex well age year drug includ lansoprazol aspirin nicorandil subset analysi reveal mc posit associ obes femal case studi demonstr causal infer mc drug howev find suggest mc associ nicorandil well lansoprazol aspirin
|
D046728;D064420
|
T047;T046;T037
|
36,271,125
|
vitamin status chimpanze human care europ wide studi vitamin defici public health concern human compar littl known vitamin level non human primat vitamin play crucial role overal health defici associ rang disord includ cardiovascular diseas lead caus death great ape serum sampl n chimpanze pan troglodyt hous european zoo measur hydroxyvitamin hydroxyvitamin total hydroxyvitamin ohd use liquid chromatographi tandem mass spectrometri sampl indic inadequ vitamin status use human refer interv ohd nmoll season year health status anim provis daili outdoor access signific effect vitamin status first larg scale studi vitamin status non human great ape human care inadequ ohd serum concentr widespread chimpanze popul europ could risk factor develop idiopath myocardi fibrosi major caus mortal speci well diseas review husbandri nutrit practic recommend ensur optim vitamin suppli endang anim
|
D002679;D014808
|
T047;T015
|
36,271,124
|
chang express nuclear factor kappa b subunit ovin thymus earli pregnanc pregnant matern immunolog toler protect fetus promot growth nuclear factor kappa b nf b famili particip regul innat immun adapt immun respons thymus relat establish central toler earli pregnanc effect express good number gene protein matern thymus sheep howev unclear whether earli pregnanc chang express nf b subunit ovin thymus studi thymic sampl collect day non pregnant ewe day pregnant ewe express nf b member nf b nf b rela relb c rel analyz real time quantit pcr western blot immunohistochem analysi result show c rel mrna protein upregul day pregnanc nf b mrna protein increas day pregnanc relb mrna protein enhanc earli pregnanc howev express level nf b rela decreas earli pregnanc upregul day pregnanc addit rela protein locat epitheli reticular cell capillari thymic corpuscl paper report first time earli pregnanc induc express nf b relb c rel inhibit express nf b rela matern thymus earli pregnanc involv central immun toler help success pregnanc sheep
|
D016328;D052003
|
T129;T123;T116
|
36,271,123
|
novel variant tle associ embryon development arrest eda famili femal infertil studi aim identifi genet caus famili femal infertil character embryon development arrest eda repeat implant failur rif oocyt donat ivf cycl use whole exom sequenc sanger valid find causat gene iranian consanguin famili infertil daughter fertil daughter fertil son patient consanguin famili exhibit typic manifest unexplain rif eda genet analysi identifi homozyg missens variant cgc pgr exon tle gene cosegreg eda phenotyp autosom recess pattern member famili gene carrier remain clinic asymptomat fertil find identifi novel nonsynonym variant cgc pgr tle gene within consanguin iranian famili autosom recess femal infertil broaden genet spectrum tle associ eda
|
D007247
|
T033;T047;T046
|
36,271,122
|
person risk predictor acut cellular reject lung transplant use solubl cd evalu contribut artifici intellig predict risk acut cellular reject acr use earli plasma level solubl cd scd combin recipi haematosi measur ratio arteri oxygen partial pressur fraction oxygen inspir pao fio respiratori sofa sequenti organ failur assess within day lung transplant ltx cd express endotheli cell leukocyt platelet act peac maker bloodvessel interfac upon nonspecif activ cd cleav releas detect plasma scd studi includ lung transplant recipi seven experienc acr model plasma level scd nonlinear depend variabl pao fio respiratori sofa time use multivari multimod model deep convolut network classifi time seri model individu associ risk acr individu cohort
|
D042783;D016040
|
T061;T025
|
36,271,121
|
gadolinium dope fluoresc carbon quantum dot mri contrast agent fluoresc probe research passiv gadolinium dope carbon quantum dot gd dope cqds synthes starch hydrotherm method x ray diffract xrd pattern gd dope cqds show format high amorph carbon fourier transform infrar spectroscopi ftir result suggest cqds function c n n h bond synthes cqds size distribut nm absorpt peak nm uv visibl spectroscopi uv vis photoluminesc pl cqds depend excit wavelength qy synthes cqds calcul gd dope cqds exhibit sustain pl ionic solut differ ionic strength differ temperatur c fluoresc imag mous c connect tissu l cell confirm gd dope cqds could well distribut cytoplasm magnet reson imag mri show gd dope cqds extrem high longitudin transvers relax valu high mm mm synthes gd dope cqds promis candid multifunct imag probe mri contrast agent biomed diagnosi brain map applic
|
D045663
|
T073
|
36,271,118
|
differ antibodi associ autoimmun diseas distinct pattern follicular cell dysregul autoantibodi produc within germin center gc process regul interact b follicular helper tfh follicular regulatori tfr cell gc dysregul human autoimmun infer circul cell albeit conflict result due divers experiment approach appli consist approach compar circul tfr tfh subset patient differ autoimmun diseas recruit particip includ patient hashimoto thyroid ht n rheumatoid arthriti ra n system lupus erythematosus sle n match healthi donor hd found frequenc circul follicular subset differ across diseas patient ht increas frequenc blood tfh cell p reduc tfrtfh ratio p compar hd observ patient system autoimmun rheumat diseas ra sle reduct tfh p p respect tfr p p respect cell result unchang tfrtfh ratio activ pd ico tfh cd pd cxcr tph cell rais patient sle p p without associ diseas activ data suggest gc dysregul assess follicular subset uniform human autoimmun specif pattern dysregul may becom potenti biomark diseas patient stratif
|
D008180;D050031
|
T047
|
36,271,117
|
glut express glial fibrillari acid protein posit tanycyt requir promot feed respons fast feed behavior complex process depend abil brain integr hormon nutrit signal glucos one glucosens mechan reli glucos transport glut hypothalamus especi radial glia like cell call tanycyt analyz whether glut depend glucosens mechan requir normal regul feed behavior gfap posit tanycyt genet inactiv glut gfap express tanycyt perform use crelox technolog effici gfap tanycyt target analyz anteroposterior dorsoventr axe evalu gfp fluoresc feed behavior hormon level neuron activ use c fos neuropeptid express also analyz fast refeed transit basal condit glut inactiv mice normal food intak meal pattern implement preceed fast period led decreas total food intak delay meal initi refeed addit glut inactiv increas number c fos posit cell ventromedi nucleus respons fast deregul pomc express fast refeed transit thus glut depend glucos sens mechan gfap tanycyt requir control food consumpt promot meal initi fast period
|
D063928;D051273;D005247
|
T123;T116;T025;T055;T040;T018
|
36,271,116
|
silico investig identifi butyl xanalter compet target ck csnka therapi chronic lymphocyt leukemia chronic lymphocyt leukemia cll incur malign b cell studi bioinformat analys conduct identifi possibl pathogen role ck protein encod csnka progress aggress cll furthermor various comput tool use search compet inhibitor ck fungal metabolit could propos cll therapi cll patient high express csnka associ earli need therapi n p short overal surviv os n p consist bioinformat analys show csnka associ withplay role cll prolifer surviv depend pathway furthermor ppi network analysi identifi interact partner ck ppi enrich p valu associ earli need therapi n p known heavili impact progress cll find construct ration target ck cll therapi consequ comput analys report fungal metabolit filter metabolit lower bind energi g kcalmol better bind affin kd compar nativ ligand g kd furthermor molecular dynam simul studi establish butyl xanalter ck complex continu remain stabl throughout simul time ns moreov butyl xanalter interact catalyt residu complex stabil hydrogen bond interact signific hydrophob interact residu phe high express csnka implic progress poor prognosi cll make potenti therapeut target diseas butyl xanalter show stabl strong interact ck thus propos competit inhibitor ck cll therapi
|
D015451
|
T191
|
36,271,115
|
u dynam neuron activ neuron convert extern stimuli action potenti spike encod contain inform biolog nervous system despit complex neuron synapt interact rate model often adapt describ neural encod modest success howev clear whether fire rate reciproc time interv spike suffici captur essenti featur neuron dynam go beyond usual relax dynam ginzburg landau theori statist system propos neural activ captur u dynam integr action potenti phase neuron togeth gain function hodgkin huxley neuron correspond dynam phase transit describ within u neuron framework addit phase depend synapt interact illustr map kinouchi copelli neuron establish suggest u neuron minim model singl neuron activ serv build block neuron network inform process
|
D008959;D009474
|
T170;T025
|
36,271,114
|
stack base artifici intellig framework effect detect local colon polyp polyp detect colonoscopi wide use method prevent colorect cancer autom process aid artifici intellig allow faster improv detect polyp miss standard colonoscopi work propos implement various object detect algorithm polyp detect improv mean averag precis map detect combin baselin model stack approach experi demonstr potenti new methodolog reduc workload oncologist increas precis local polyp propos achiev map translat improv compar best baselin model respect weight box fusion ensembl techniqu
|
D003111;D015179
|
T191;T190
|
36,271,113
|
genet introgress differ group reveal differenti process asian cultiv rice asian cultiv rice consist two major subspeci indica japonica alreadi mani report exist genet introgress two subspeci propos possibl introgress relat gene comparison popul paramet studi use genom wide variat data asia cultiv rice investig genet introgress whole genom level detect total signific high introgress loci tropic japonica indica popul two differ method use identifi genet introgress region detect introgress region general get consist result previous known introgress gene detect identifi introgress loci heat resist gene tt glw biolog function genet introgress region annot publish qtl map result find genet introgress play vital role determin phenotyp domest process differ group studi also provid use inform resourc studi rice gene function domest process
|
D012275
|
T168;T002
|
36,271,111
|
clinic frailti assess might associ mortal incid dialysi patient frailti associ mortal mainten dialysi patient incid dialysi patient use clinic frailti scale cfs investig frailti relat mortal hospit within year retrospect review medic record patient initi hemodialysi periton dialysi base record two dialysi nurs independ use point cfs fit termin ill assess patient frailti dialysi initi patient mean cfs valu higher classifi frail group year surviv rate hospit free rate initi dialysi compar frail mean cfs score non frail mean cfs score group analysi includ incid dialysi patient mean age male frailti infer patient dialysi initi kaplan meier analys show surviv rate hospit free rate within year signific lower frail group non frail group p cox proport hazard regress analys reveal cfs score associ occurr composit outcom independ age hazard ratio confid interv frailti assess base clinic judgment use cfs might predict advers outcom dialysi initi patient
|
D000073496;D015673
|
T033;T184;T047;T046
|
36,271,110
|
predict decreas estim glomerular filtrat rate use liver fibrosi marker renal biopsi base studi non alcohol fatti liver diseas common chronic liver diseas associ chronic kidney diseas fibrosi index non alcohol fatti liver diseas score wide use non invas diagnost method non alcohol fatti liver diseas howev relationship marker specif renal histopatholog chronic kidney diseas remain unclear studi includ patient age year underw renal biopsi examin associ fibrosi index non alcohol fatti liver diseas score chang estim glomerular filtrat rate month kidney biopsi renal histopatholog renal histopatholog determin renal biopsi result show signific negat correl fibrosi index estim glomerular filtrat rate nephrosclerosi non alcohol fatti liver diseas score estim glomerular filtrat rate tend negat correl albeit without signific iga nephropathi fibrosi index non alcohol fatti liver diseas score signific negat correl estim glomerular filtrat rate furthermor fibrosi index associ urinari protein creatinin ratio renal function marker urinari b microglobulin urinari n acetyl glucosamin kidney biopsi base studi show liver fibrosi marker fibrosi index non alcohol fatti liver diseas score negat correl estim glomerular filtrat rate nephrosclerosi iga nephropathi
|
D009400;D065626;D005922;D051436
|
T047
|
36,271,109
|
pharmacolog effect caffein ventil adult zebrafish free swim condit zebrafish wide use model biolog studi particular heart rate cortisol level zebrafish common measur elucid pharmacolog effect chemic substanc meanwhil although ventil also import physiolog index reflect emot like state studi evalu effect chemic ventil adult zebrafish studi assess whether possibl evalu pharmacolog effect elicit caffein adult zebrafish free swim condit measur ventil adult zebrafish expos multipl concentr caffein restraint free swim condit evalu pharmacolog effect caffein use linear mix model analysi addit result electrocardiogram analysi swim speed compar previous report ensur appropri dose caffein administ restraint condit caffein signific decreas heart rate increas ventil concentr depend manner free swim condit ventil rate signific increas increas caffein concentr result indic pharmacolog effect elicit chemic ventil evalu free swim zebrafish
|
D015027;D002110
|
T121;T109;T013
|
36,271,108
|
femal bonobo show social swell synchron maximum swell increas bond differ old world primat show conspicu anogenit swell maximum swell phase msp signal ovulatori phase msp synchron femal link social dynam bonobo character femal domin msp fulli reliabl signal fertil may cover anovulatori period investig whether bonobo femal synchron msp whether phenomenon modul social factor data collect la vall des sing franc period swell cycl data collect daili bonobo femal n period etholog data aggressionaffiliationsocio sexual behavior also collect found femal synchron msp like experienc msp onset follow msp onset femal ii synchron increas year spent togeth femal increas iii synchron preferenti occur femal affili less iv synchron msp link increas femal femal socio sexual contact probabl favor msp synchron mainten henc bonobo msp modul social factor synchron possibl under autonom contagion might posit select evolut relat benefit femal obtain term intra group cohes
|
D019974;D012726
|
T015;T054
|
36,271,107
|
compost willow biomass salix viminali l horticultur substrat altern peat product veget transplant willow salix viminali l speci well adapt environ condit central europ main cultiv energi purpos solid fuel studi evalu suitabl purpos made use year old short rotat coppic src willow regrowth produc chip biomass compost four compost method use without addit wc addit nitrogen narrow c n ratio wn addit mycelium wpg addit mycelium nitrogen wpgn mixtur wc wpgn compost also prepar volum compost differ proport peat sm evalu suitabl substrat tomato cucumb transplant product tomato transplant produc medium prepar mixtur willow compost wpgn wc wpgn wc mixtur peat wpgn wc sm wpgn wc sm characteris best paramet plant height later leaf span number leav similar cucumb transplant better growth condit peat substrat obtain variant wpgn wc wpgn wc sm addit nitrogen compost biomass posit influenc compost process n concentr substrat high toxic growth tomato cucumb transplant end tomato cucumb experi nitrat content mg dm respect wn substrat similar high n content compost willow substrat addit nitrogen mycelium promot growth tomato cucumb base research least mass peat replac differ willow compost without advers impact seedl growth willow compost mixtur could high
|
D032108;D000076282;D018551;D018553
|
T068;T167;T168;T002
|
36,271,106
|
structur pre mrna leakag kda protein reveal singl domain integr zf chc rsm modul saccharomyc cerevisia pre mrna leakag kda protein scpml report retain unsplic pre mrna prior export nuclear pore complex npcs pml homolog outsid saccharomycetacea famili current unknown mechanist insight pml function lack determin crystal structur scpml resolut facilit discoveri ortholog beyond saccharomycetacea eg schizosaccharomyc pomb human crystal structur reveal integr zf chc rsm modul tight associ hydrophob interfac form singl domain zf chc rsm modul belong zn contain bir baculovirus iap repeat like super famili key residu canon bir domain conserv featur uniqu pml modul refer space zn coordin residu give rise substanti tilt helix c zf chc rsm modul extra helix ab rsm modul conserv key residu respons distinct featur identifi pomb rsm homo sapien nipazchc structur ortholog scpml base recent function character nipazchc scaffold protein stabil nuclear basket npc data suggest analog function scpml cerevisia
|
D009687;D029701
|
T123;T116
|
36,271,105
|
variat characterist impact urban extrem precipit shanghai rapid develop urban characterist extrem precipit urban area chang signific reveal spatial tempor distribut extrem precipit chang environ basi scientif respons urban flood trend extrem precipit threshold shanghai influenc urban analyz result show precipit threshold limit valu site mm variat factor mm variat factor precipit threshold condit signific differ among station extrem precipit site increas past year growth rate extrem precipit respect growth rate extrem precipit signific higher averag precipit extrem part precipit probabl distribut increas consider strong variabl extrem precipit region threshold precipit vari extrem precipit shanghai signific posit correl urban area around site urban increas effect region extrem precipit extrem precipit greater growth rate high urban area
|
D014507;D055868
|
T068;T083;T070
|
36,271,104
|
contrast volum hospit outcom dialysi patient undergo percutan coronari intervent toxic result retain contrast media may caus advers cardiovascular outcom eg heart failur cardiogen shock dialysi patient howev associ administ contrast volum outcom dialysi patient percutan coronari intervent pci suffici investig evalu consecut dialysi patient age year acut coronari syndrom underw pci septemb march patient divid two group contrast volum ml contrast volum ml cutoff ml ml increment contrast volum known rais risk acut kidney injuri ml averag volum use pci center primari endpoint composit hospit death post pci cardiogen shock post pci heart failur multivari logist regress model smooth spline curv construct assess associ contrast volum primari endpoint median contrast volum ml interquartil rang ml overal primari endpoint incid n contrast volum ml associ higher risk primari endpoint odd ratio confid interv p smooth spline curv demonstr linear relationship contrast volum primari endpoint conclus contrast volum associ advers hospit outcom dialysi patient undergo pci attent focus contrast volum use dialysi patient undergo pci
|
D062645;D006333
|
T061;T047;T046
|
36,271,103
|
efflux suscept antibiot adjuv system efficaci mous infect scarciti effect treatment sepsi daunt especi contemporari standpoint antibiot resist entail develop altern treatment strategi describ design antibiot adjuv properti new lipopeptid like pentam decanoyl bisdiaminobutyr aminododecanoyl diaminobutyr amid c bbc b whose sub maxim toler dose combin ineffici antibiot demonstr system efficaci murin model periton sepsi urinari tract infect attempt shed light mechan action use membran activ fluoresc probe suggest outer membran interact domin pentam adjuv properti associ typic inner membran damag delay bacteri growth yet checkerboard titrat low micromolar concentr c bbc b exhibit unpreced capac potenti hydrophob antibiot toward gram negat eskap pathogen appar low propens prompt resist antibiot assess pentam potenti activ upon efflux inhibit incit submiss hitherto unreport probabl action mechan implic pentam de facto capac hijack bacteri efflux pump boost adjuv activ repetit step includ outer membran adhes transloc subsequ expuls
|
D000900;D018805
|
T121;T047;T046;T195
|
36,271,102
|
transcript target senataxin e promot bind factor associ neuro degen pathway increas autophag flux autophagi intracellular recycl process degrad harm molecul enabl surviv starvat implic diseas includ dementia cancer atherosclerosi previous studi demonstr limit number transcript factor tfs increas autophagi howev knowledg result translat therapi thus gain understand suitabl target util system biolog approach induc autophagi amino acid starvat mtor inhibit hela hek sh syy cell measur tempor gene express use rna seq observ differenti express gene due starvat gene due mtor inhibit p fdr everi cell line pathway analys implic alzheim parkinson diseas p fdr sh syy hela amyotroph later sclerosi al p fdr mtor inhibit experi differenti express senataxin setx target gene set predict activ multipl neurodegen pathway p fdr sh syy cell neuron origin ef transcript famili predict activ alzheim diseas pathway p fdr exploratori analys suggest setx ef may mediat transcript regul autophagi investig possibl role neuro degener warrant
|
D004265;D064251;D020365
|
T126;T116
|
36,271,101
|
cannabidiol improv nile tilapia cichlid fish welfar cannabidiol cbd substanc deriv cannabi sativa wide studi medicin control neural diseas human besid posit effect human also present anxiolyt proprieti decreas aggress stress mammal therefor cbd potenti increas welfar rear anim seem reduc negat state common experienc artifici environ test effect differ cbd dose mgkg aggress stress reproduct develop nile tilapia oreochromi niloticus fish rear worldwid farm research purpos cbd mix fish food offer isol fish week mgkg dose decreas fish aggress time wherea mgkg attenu non social stress dose decreas baselin cortisol level fish increas gonadosomat index howev cbd mgkg dose decreas spermatozoa number cbd dose affect feed ingest growth variabl show harm meat product amount despit effect spermatozoa cbd supplement exhibit high potenti benefit anim live artifici environ therefor show first time cbd could use tool increas non mammal welfar present great potenti explor husbandri captiv speci
|
D023681;D002185;D014151;D002188
|
T121;T109;T002;T039;T167;T013
|
36,271,100
|
spontan symmetri break propuls chemic coat magnet microparticl chemic coat micronanoparticl often use medicin enhanc drug deliveri increas drug take specif area bodi use recent discov spontan symmetri break propuls mechan demonstr chemic coat microparticl swim mucus solut precis navig certain function dynam chang propuls behavior investig biotin bitotin peg amin biotin chitosan chemic function onto surfac magnet microparticl use avidin biotin complex chemic chosen use prolif drug deliveri applic peg chitosan well known mucoadhes effect coat microparticl suspend mucus synthes porcin stomach mucin propel use rotat magnet field relationship differ chemic coat microparticl veloc control thorough explor discuss result indic biotinyl surfac coat alter propuls behavior microparticl perform differ interlink magnet field properti local mucus properti precis control drug carri microparticl envis help supplant tradit drug deliveri method enhanc exist medic techniqu util micronanoparticl
|
D048271
|
T121;T109
|
36,271,099
|
map periplasm bind protein oligosaccharid recognit neutron crystallographi numer studi shown periplasm bind protein pbps bind substrat exquisit specif even distinguish sugar epim anom structur similar ion yet mark substrat promiscu also featur encod pbps except three sub ngstrm crystal structur report hydrogen atom posit remain pbp structur previous x ray crystal structur maltodextrin periplasm bind protein thermotoga maritima tmmbp complex oligosaccharid show larg network interconnect water molecul stretch one end substrat bind pocket water molecul posit form multipl hydrogen bond well form interact protein substrat present neutron crystal structur tmmbp resolut first neutron crystal structur pbp superfamili unambigu identifi natur orient hydrogen bond water mediat interact involv stabil tetrasaccharid bind site broad result demonstr conserv intric mechan underli substrat specif affin pbps
|
D033902
|
T123;T116
|
36,271,098
|
cell sort microbead novel contrast agent magnet reson imag success sever cell base therapi preval use magnet reson imag mri clinic fuel develop contrast agent specif cell track applic safe effici label non phagocyt cell type cell nonetheless remain challeng develop one stop shop approach cell sort agent also label cell subsequ depict use non invas mri compar mr signal effect magnet assist cell sort microbead cd current preclin gold standard ferumoxytol investig vitro label effici regulatori cell treg mri histopatholog confirm thereaft treg cell label cd microbead vitro deliv via intraven inject liver mris pre h post inject perform determin vivo track feasibl show cd microbead exhibit signal decay properti similar iron oxid contrast agent cd microbead readili intern treg detect non invas mri dose depend signal suppress system inject label treg detect liver h post inject contrari cell control cd microbead base label method effect tool treg tag yield detect mr signal chang cell phantom vivo novel cellular track method key track fate treg inflammatori patholog solid organ transplant
|
D003287;D052203
|
T121;T197;T130
|
36,271,097
|
high resolut crop yield water product dataset generat use random forest remot sens accur high resolut crop yield crop water product cwp dataset requir understand predict spatiotempor variat agricultur product capac howev dataset maiz wheat two key stapl dryland crop china current lack studi generat evalu long term data seri km resolut crop yield cwp maiz wheat across china base multipl remot sens indic random forest algorithm result show mod product accur altern eddi covari flux tower data describ crop evapotranspir maiz wheat rmse mmd respect propos yield estim model show accuraci local maiz wheat rrmse respect region maiz wheat rrmse respect scale analys show spatiotempor pattern maiz wheat yield cwp across china use optim agricultur product strategi context maintain food secur
|
D018556;D062066
|
T070;T002
|
36,271,096
|
machin learn model identifi predictor clinic outcom first line immun checkpoint inhibitor therapi advanc non small cell lung cancer immun checkpoint inhibitor ici standard care first line l therapi advanc non small cell lung cancer ansclc without action oncogen driver mutat clinic trial demonstr benefit ici chemotherapi variat outcom across patient observ trial popul may repres clinic practic predict model help understand heterogen treatment effect identifi predictor meaning clinic outcom may inform treatment decis appli machin learn ml base surviv model real world cohort patient ansclc receiv l ici therapi extract us base electron health record databas model perform evalu use metric includ concord index c index use explain techniqu identifi signific predictor overal surviv os progress free surviv pfs ml model achiev c indic os pfs respect kaplan meier surviv curv show signific differ low high risk group os pfs log rank test p identifi predictor most consist publish literatur andor clinic expect larg overlap os pfs eastern cooper oncolog group perform status program cell death ligand express level serum albumin among top predictor outcom prospect independ data set evalu requir confirm result
|
D002289;D000082082;D008175
|
T121;T129;T191;T043
|
36,271,093
|
sever test high dimension omic data enhanc biomed scientif discoveri high throughput omic experi provid wealth data explor biomed question advanc translat research howev despit great potenti result enter clinic practic scarc even twenti year complet human genom project reason paper revisit problem scientif discoveri common summar term reproduc crisi argu major problem hamper progress translat research threefold first order establish biolog foundat disord general complex phenotyp one need embrac emerg second seem confus under hypothes test omic studi third contemporari omic studi design perform seen increment corrobor hypothesi order improv upon shortcom defin sever test framework stf appli larg number omic studi enhanc scientif discoveri biomed scienc briefli stf provid systemat mean trim wild grown omic studi construct way
|
D057170
|
T062
|
36,271,092
|
singl cell transcriptom profil neuron astrocyt assembloid tauopathi model use ipsc deriv brain organoid model studi neurodegen diseas hamper lack system accur expediti recapitul pathogenesi context neuron glial interact report develop system term asttau propag toxic human tau oligom ipsc deriv neuron astrocyt assembloid asttau system develop much neuron astrocyt patholog observ tauopathi includ misfold phosphoryl oligomer fibrillar tau strong neurodegener reactiv astrogliosi singl cell transcriptom profil combin immunochemistri character model system close recapitul late stage chang adult neurodegener transcriptom studi demonstr strike chang neuroinflammatori heat shock protein hsp chaperon system diseas process treatment hsp inhibitor pu h use address putat dysfunct hsp chaperon system produc strong reduct patholog neurodegener highlight potenti asttau rapid reproduc tool drug discoveri
|
D019636;D024801
|
T047
|
36,271,085
|
document smoke schedul asthma contact primari health care year follow studi smoke among asthmat common associ poorer asthma control rapid lung function declin higher health care cost dose depend manner previous real life studi exist howev smoke status pack year document schedul asthma contact primari health care phc long term follow often patient advis quit smoke real life year follow studi show schedul phc asthma contact n smoke mention pack year smoke data record even never smoker ex smoker current smoker smoke includ pack year mention often nurs took part schedul contact current smoker smoke cessat recommend schedul contact current smoker use antibiot unschedul health care contact follow
|
D012907;D001249
|
T055;T047
|
36,271,083
|
wash activ control endosom recycl egfr hippo signal tumor suppress cell competit cell competit conserv homeostat mechan wherebi epitheli cell elimin neighbor lower fit cell communic interfac wild type winner cell polar defici scrib loser establish sas mediat ptpd activ polar defici cell tumor suppress cell competit restrain egfr hippo signal enabl eiger jnk mediat apoptosi scrib clone show activ state endosom actin regul wash central node link egfr hippo signal activ tyrosin kinas btka substrat wash requir downstream ptpd loser cell elimin constitut activ phosphomimet wash suffici induc egfr yki activ lead overgrowth mechanist level show ptpd recycl washretrom complex egfr recycl washretriev complex constitut wash activ select interfer retrom function lead ptpd mistarget promot egfr recycl signal activ phospho wash also activ aberr arp actin polymer lead cytoskelet imbal yki activ reduc apoptosi select manipul wash phosphoryl sort endosom may restrict epitheli tumor growth
|
D000084502;D009369
|
T191;T043
|
36,271,079
|
web social media search highlight menstrual irregular global concern covid vaccin delin public concern prevent vaccin complianc major step generat assur enhanc success covid prevent program therefor sought identifi public concern associ covid vaccin reflect web social media search focus menstrual irregular use trajectori analys web social media search data combin global covid data reveal time depend correl vaccin rate relat volum vaccin period relat search surg period vaccin relat googl search follow introduct covid vaccin around world commenc vaccin program english speak countri across unit state relat volum search covid vaccin menstrual irregular covid vaccin menstrual period pfizer vaccin menstruat moderna vaccin menstruat signific correl vaccin rate spearman r p signific differ introduct covid vaccin mann whitney p tiktok user engag period problem ever intern nation state level correl covid vaccin onlin activ demonstr global major concern vaccin relat menstrual irregular whether potenti side effect unfound worri monitor web social media activ could reveal public percept covid prevent effort could direct address translat insight public health strategi
|
D061108;D000086382;D014612
|
T121;T129;T116;T067;T170;T047
|
36,271,078
|
reduc rotat flow enabl translat surfac roll microrobot confin space biolog microorgan overcom brownian motion low reynold number util symmetri break mechan inspir various microrobot locomot method develop microscal break hydrodynam symmetri although boundari effect extens studi microswimm employ surfac roll microrobot behavior microrobot proxim multipl wall base confin yet elucid studi confin effect motion surfac roll microrobot experi demonstr locomot effici spheric microrol drastic decreas confin space due plane rotat flow generat locomot henc slender microrol design generat smaller rotat flow shown outperform spheric microrol confin space result elucid under physic surfac roll base locomot confin space present design strategi optim flow generat effici propuls area includ blood vessel microchannel
|
D012371
|
T090
|
36,271,077
|
popul genom puccinia gramini fsp tritici highlight role admixtur origin virul wheat rust race puccinia gramini fsp tritici pgt caus stem rust diseas wheat result sever yield loss factor drive evolut virul adapt remain poor character util long read sequenc develop haplotyp resolv genom assembl us isol pgt use pgt haplotyp refer character structur variant svs singl nucleotid polymorph divers panel isol svs impact repertoir predict effector secret protein involv host pathogen interact show evid purifi select analyz global local genom ancestri demonstr origin pgt clade link either somat hybrid sexual recombin diverg donor popul studi show svs admixtur event appear play import role broaden pgt virul origin high virul race creat resourc studi evolut pgt virul prevent futur epidem outbreak
|
D014908;D001487
|
T168;T004;T002
|
36,271,076
|
crisprca mediat excis alsftd caus hexanucleotid repeat expans corf rescu major diseas mechan vivo vitro ggggcc hexanucleotid repeat expans hre corf gene common genet caus amyotroph later sclerosi al frontotempor dementia ftd fatal neurodegen diseas cure approv treatment substanti slow diseas progress extend surviv mechanist underpin neuron death includ corf haploinsuffici sequestr rna bind protein nucleus product dipeptid repeat protein use adeno associ viral vector system deliv crisprca gene edit machineri effectu remov hre corf genom locus demonstr success excis hre primari cortic neuron brain three mous model contain expans repeat well patient deriv ipsc motor neuron brain organoid repeat result reduct rna foci poli dipeptid haploinsuffici major hallmark c alsftd make promis therapeut approach diseas
|
D057180;D000690
|
T047;T048
|
36,271,075
|
incorpor evolutionari threat process crop wild relat conserv crop wild relat cwr intra interspecif divers essenti crop breed food secur howev intraspecif genet divers central given idiosyncrat threat speci landscap usual consid plan framework introduc approach develop proxi genet differenti identifi conserv area appli systemat conserv plan tool produc hierarch priorit landscap account evolutionari process includ histor environment driver genet divers ii threat process consid taxa specif toler human modifi habitat extinct risk status analys use input develop nation action plan conserv use cwr result also inform public polici mitig threat process cwr like crop live modifi organ agricultur subsidi could advis futur research eg potenti germplasm collect although focus mesoamerican cwr within mexico methodolog offer opportun effect guid conserv monitor strategi safeguard evolutionari resili taxa includ region complex evolutionari histori mosaic landscap
|
D003247;D000069600
|
T078;T040;T069;T081;T064
|
36,271,074
|
singl nuclei bulk tissu gene express analysi pheochromocytoma paraganglioma link diseas subtyp tumor microenviron pheochromocytoma pc paraganglioma pg rare neuroendocrin tumor associ autonom nerv use singl nuclei rna seq bulk tissu gene express data character cellular composit pcpg normal adren tissu refin tumor gene express subtyp make clinic genotyp associ confirm seven pcpg gene express subtyp signific genotyp clinic associ tumor mutat vhl sdh encod gene sdhx maml fusion character hypoxia induc factor signal neoangiogenesi pcpg infiltr lymphocyt abund macrophag neoplast cell transcript resembl matur chromaffin cell earli chromaffin neuroblast marker also featur pcpg subtyp gene express profil metastat sdhx relat pcpg indic tumor elev cellular prolifer lower number non neoplast schwann cell like cell gpr potenti theranost target find therefor clarifi divers transcript program cellular composit pcpg identifi biomark potenti clinic signific
|
D010673;D010235;D000310
|
T191
|
36,271,073
|
dna methyltransferas control intestin epitheli barrier function regener colon genet variant dna methyltransferas dnmta locus associ inflammatori bowel diseas ibd dnmta part epigenet machineri physiolog involv dna methyl show dnmta play critic role maintain intestin homeostasi gut barrier function dnmta express downregul intestin epitheli cell ibd patient upon tumor necrosi factor treatment murin intestin organoid ablat dnmta caco cell result global dna hypomethyl link impair regen capac transepitheli resist intercellular junction format genet delet dnmta intestin epitheli cell dnmta iec mice confirm phenotyp alter epitheli ultrastructur shorten apic junction complex reduc goblet cell number increas intestin permeabl colon vivo dnmta iec mice suffer increas suscept experiment coliti character reduc epitheli regener data demonstr critic role dnmta orchestr intestin epitheli homeostasi respons tissu damag suggest involv impair epitheli dnmta function etiolog ibd
|
D000090205;D015212
|
T047;T126;T116
|
36,271,072
|
experiment valid memrist memori augment neural network effici hash similar search lifelong devic learn key challeng machin intellig requir learn often singl sampl memori augment neural network propos achiev goal memori modul must store chip memori heavili limit practic use work experiment valid differ structur memori augment neural network implement fulli integr memrist crossbar platform accuraci close match digit hardwar success demonstr support implement new function crossbar includ crossbar base content address memori local sensit hash exploit intrins stochast memristor devic simul show implement effici scale one shot learn complex task success demonstr pave way practic devic lifelong learn open possibl novel attent base algorithm possibl convent hardwar
|
D016571;D000465
|
T170
|
36,271,063
|
multiparamet optim system dcnn precis agricultur advanc irrig plan schedul base soil moistur estim agricultur distinct sector countri economi recent year new pattern evolv agricultur industri conjunct sensor scale precis agricultur field remot sensor network wireless sensor network wsn develop major purpos make horticultur oper simpler identifi assess manag paper use propos dcnn predict soil moistur plan irrig precis agricultur farmer reduc water consumpt use cultiv increas product yield compar water content various stage plant growth integr iot applic agricultur also optim water level futur irrig decis maintain crop growth water stabil data must serv store form grid view accord apriori gru gate recurr unit use numer sensor paramet model methodolog system assist predict irrig plan base irrig need predict paramet includ soil moistur temperatur humid observ experiment data support smart irrig crop product high yield littl water use dcnn experiment result accuraci rate mse valu predict dcnn time
|
D012987;D004784
|
T167;T057
|
36,271,053
|
splice factor bud promot ovarian cancer progress sustain express anti apoptot bcll dysregul express splice factor import role cancer develop progress howev remain challeng identifi cancer specif splice variant demonstr spliceosom compon bud increas ovarian cancer higher express predict wors prognosi character bud bind motif find bud preferenti bind exon intron region near splice site analysi reveal bud inhibit result extens exon skip reduc product long isoform contain full code sequenc particular identifi bcll anti apoptot bcl famili member one function splice target bud bud stimul inclus exon generat full length bcll promot ovarian cancer progress knockdown bud splice switch antisens oligonucleotid treatment promot exon skip result truncat isoform bcll undergo nonsens mediat mrna decay cell subsequ undergo apoptosi find reveal bud regul exon inclus critic factor ovarian cancer cell surviv cancer progress
|
D017398;D010051
|
T045;T191;T123;T114
|
36,271,051
|
function architectur execut control associ event relat potenti macaqu medial frontal cortex mfc enabl execut control monitor relev inform use adapt behavior macaqu perform saccad countermand stop signal task simultan record electr potenti mfc neural spike across layer supplementari eye field sef report laminar organ neuron enabl execut control monitor conflict incompat respons time event sustain goal mainten neuron mix narrow spike broad spike found layer predict durat control sustain task goal releas oper control common narrow spike neuron confin layer l complement result evid monkey homolog np event relat potenti erp complex associ respons inhibit n polar vari error likelihood p polar vari durat expect control amplitud n p predict spike rate differ class neuron locat l l find reveal featur cortic microcircuitri support execut control produc associ erp
|
D056344;D008251
|
T015;T041
|
36,271,049
|
wnt heterogen activ matur cell control calcium signal metabol function diabet multifactori disord character loss dysfunct pancreat cell cell heterogen exhibit differ glucos sens insulin secret gene express communic endocrin cell type via paracrin signal cell via gap junction identifi import signal cell via extracellular signal wnt show heterogen wnt express strike postnat matur period wnt posit cell matur wnt negat cell prolif knock adult cell show wnt control activ calcium signal respons glucos challeng well metabol pathway converg lower atpadp ratio therebi reduc insulin secret result reveal paracrin signal cell import addit gap junction control insulin secret togeth previous report wnt regul obes observ suggest adapt insulin respons coordin cell
|
D020013;D061385
|
T121;T043
|
36,271,048
|
reward avers process input defin parallel nucleus accumben circuit mice nucleus accumben nac critic mediat reward seek also involv negat emot process cellular circuitri mechan under oppos behavior remain elus use recent develop aav mediat anterograd transsynapt tag techniqu mice show nac neuron receiv basolater amygdala input nac bla promot posit reinforc via disinhibit dopamin neuron ventral tegment area vta contrast nac neuron receiv paraventricular thalam input nac pvt innerv gabaerg neuron later hypothalamus lh mediat avers silenc synapt output nac bla neuron impair reward seek behavior silenc nac pvt nac pvt lh pathway abolish avers symptom opiat withdraw result elucid affer specif circuit architectur nac control reward avers
|
D009714;D053610
|
T121;T023;T131;T109
|
36,271,047
|
prime condit shape breadth neutral antibodi respons sarbecovirus vaccin broad cross protect current futur sar cov variant concern voc across sarbecovirus subgenus remain prioriti public health virus neutral best avail correl protect defin magnitud breadth cross neutral individu differ exposur sar cov infect vaccin use multiplex surrog neutral assay base virus spike receptor bind domain multipl sar cov voc well relat bat pangolin virus includ sera cohort individu vaccin two three dose mrna bntb inactiv sar cov coronavac sinopharm vaccin without histori previous sar cov sar cov infect sar cov sar cov infect follow bntb vaccin omicron ba breakthrough infect follow bntb vaccin third dose bntb follow two dose bntb coronavac elicit highest broadest neutral across voc breadth magnitud neutral across sarbecovirus infect sar cov immun bntb outperform combin infect andor vaccin data may inform vaccin design strategi generat broad neutral antibodi sar cov variant across sarbecovirus subgenus
|
D057134;D000086382
|
T129;T047;T116;T067
|
36,271,046
|
influenza virus pb protein evad antivir innat immun inhibit jakstat signal influenza virus iav polymeras protein pb shown partial inhibit host immun respons block induct interferon ifn howev iav pb protein regul downstream signal pathway ifn well character report iav pb protein reduc cellular sensit ifn suppress activ statstat isg furthermor iav pb protein target mammalian jak lysin ubiquitin degrad notabl h subtyp high pathogen avian influenza virus imkr mutat pb increas abil degrad mammalian jak exhibit higher replic effici mammalian avian cell mous lung tissu caus greater mortal infect mice altogeth data describ negat regulatori mechan involv pb jak provid insight evas strategi host antivir immun employ iav
|
D000998;D009980
|
T121;T005
|
36,271,045
|
tempor program polym solvent interact use chemic reaction network equilibrium oper chemic reaction network crns enabl artifici materi autonom respond environ activ deactiv intermolecular interact general activ driven various chemic convers yet deactiv non interact build block remain larg limit hydrolysi intern ph chang achiev control deactiv present new modular crn enabl revers format posit charg tertiari amin substrat remov use nucleophil signal control deactiv kinet modular natur crn enabl incorpor divers polym materi lead tempor program transit collaps hydrophob solvat hydrophil polym chain control polym solvent interact depend layout crn creat stimuli respons autonom respond materi concept offer new opportun molecular cargo deliveri also pave way next generat interact materi
|
D011108;D020100
|
T104;T122
|
36,271,044
|
transcriptom wide stratifi genom structur equat model identifi neurobiolog pathway share across divers cognit trait function genom method need consid multipl genet correl trait develop valid transcriptom wide structur equat model sem multivari method studi effect tissu specif gene express across genet overlap trait sem allow model effect broad dimens span constel trait safeguard fals posit aris effect gene express specif subset trait appli sem investig biolog mechan share across seven distinct cognit trait n index general dimens genet share g identifi gene whose tissu specif express associ g includ gene identifi univari analysi individu cognit trait tissu type three gene whose express explain signific portion genet share across g differ subclust psychiatr disord go appli stratifi genom sem identifi enrich g within function categori includ categori index intersect protein truncat variant intoler pi gene specif neuron cell type also find enrich genet covari g psychot disord factor
|
D055106;D059467
|
T063;T081;T086
|
36,271,035
|
refer gene develop mous lung consider biolog technic experiment confound gene express analysi raw data obtain rt qpcr prefer normal refer gene constant express regardless experiment condit select refer gene particular challeng develop lung complex transcript epigenet regul gene organ matur injuri repair date limit experiment data address reliabl refer gene biolog circumst studi evalu refer gene lung neonat cbl mice consider biolog technic experiment condit thorough select candid common use refer gene side side novel one analyz public avail microarray dataset perform rt qpcr select candid gene analyz express variabl use genorm normfind cell specif express candid gene analyz use singl cell rna sequenc data develop mous lung depend investig condit ie development stage sex rna qualiti experiment condit hyperoxia cell type distinct candid gene demonstr stabl express confirm elig reliabl refer gene result provid valuabl inform select proper refer gene studi investig neonat mous lung
|
D020869;D044127
|
T063;T045;T059
|
36,271,027
|
adsorpt characterist mechan cd aqueous solut biochar deriv corn stover corn stover could pyrolys prepar biochar remov pollut water realiz resourc util biomass aim present studi investig optim prepar adsorpt condit biochar reveal adsorpt characterist mechan cd water biochar purpos cd target pollut pyrolysi condit involv pyrolysi temperatur retent time heat rate evalu optim addit characterist mechan optim adsorpt condit cd biochar determin seri character techniqu employ includ scan electron microscopi sem fourier transform infrar spectroscopi ftir x ray diffract xrd specif surfac area analysi bet optimum pyrolysi paramet pyrolysi temperatur c retent time h heat rate cmin acidbas modif improv adsorpt capac biochar langmuir elovich model suitabl isotherm kinet model equilibrium data respect maximum adsorpt capac fit langmuir model mgg furthermor miner precipit electron interact shown main adsorpt mechan cd optimum adsorpt condit cd water cacl electrolyt solut moll ph level biochar dosag g result indic corn stover biochar appropri approach improv status water cd contamin short term promot new perspect ration util corn stover low cost pollut control heavi metal water
|
D014874;D019216
|
T131;T196
|
36,271,026
|
data set distribut global popul water withdraw popul water withdraw data set current face difficulti collect process verifi multi sourc time seri spatial distribut characterist long seri also relat lack time seri basic guarante accuraci data set product long seri spatial distribut realist requir expand applic scope data set time consum labori basic process work research focus popul water intak time seri interpol extend specif land use ensur accuraci time seri demand spatial distribut data set research provid set popul densiti water intens product distribut administr unit correspond region data set fill gap multi year data set accuraci popul densiti intens water withdraw
|
D062066;D011157
|
T078;T081;T070;T052
|
36,271,025
|
one pot synthesi naphtho e oxazin presenc fnaosipamp cu ii almond shell base nanocatalyst present research work novel catalyst base natur materi name fe nano almondshel osi ch nhch pyridinecu ii abbrevi fnaosipampcu ii design prepar properti catalyst identifi fourier transform infrar spectroscopi ft ir thermogravimetri ananlysi tg x ray diffract xrd energi dispers x ray spectroscopi ed field emiss scan electron microscopi fesem transmiss electron microscopi tem map furthermor evalu catalyt activ done cours naphtho oxazin synthesi solvent free condit simplic oper easi work use eco friend catalyst advantag protocol
|
D010078;D000068181
|
T168;T002;T109
|
36,271,022
|
bullet impact build stone excav approxim conic crater dimens control target materi bullet impact ubiquit form damag built environ result arm conflict bullet impact stone build result surfici crater fractur chang materi properti permeabl surfac hard control experi two differ sedimentari stone conduct characteris surfac damag investig relationship impact energi function engag distanc crater volum simplifi geometri crater volum use depth diamet measur show volum simpl cone provid best approxim within crater volum measur photogrammetri model result suggest quick effici method estim crater volum field assess damag impact energi littl consist effect crater volum engag distanc studi differ target materi result order magnitud variat measur crater volum bullet impact experi similar appear damag caus hyperveloc experi crater excav driven momentum transfer target rather hemispher shock wave therefor contrast predict impact scale relationship hyperveloc experi target materi play domin role control damag projectil energi
|
D019110;D002137
|
T072;T031
|
36,271,021
|
differ time risk factor caus specif pancrea graft loss simultan pancrea kidney transplant case pancrea transplant ptx pancrea graft might lost various reason includ pancreatoduoden graft relat complic patient death function graft although caus seem distinct characterist caus pancrea graft loss character studi aim character caus pancrea graft loss analyz data japanes nationwid registri studi includ patient receiv simultan pancrea kidney transplant among patient ptx studi period approv institut japan character caus term time caus specif graft loss preoper factor associ graft loss base nationwid data japanes nationwid registri among case lost pancrea graft due patient death function graft dwfg n graft thrombus n chronic reject cr n averag standard deviat time ptx graft loss due dwfg graft thrombus cr year respect durat type diabet mellitus donor bodi mass index signific associ pancrea graft loss due dwfg graft thrombus respect character show time preoper factor associ pancrea graft loss signific differ differ caus graft loss result may inform ptx follow protocol ensur appropri care base caus graft loss
|
D016035;D016030
|
T061
|
36,271,020
|
machin learn approach explor predictor graft detach follow posterior lamellar keratoplasti nationwid registri studi machin learn use explor complex multifactori pattern under postsurg graft detach endotheli corneal transplant surgeri evalu margin effect various practic pattern modul includ posterior lamellar keratoplasti procedur record dutch cornea transplant registri collect center specif practic pattern use questionnair avail data regard donor recipi surgeri practic pattern code factor might associ occurr graft detach research use three machin learn method regular logist regress lasso classif tree analysi cta random forest classif rfc select predict subset variabl graft detach total transplant includ analysi overal preval graft detach independ test set area curv lasso cta rfc respect identifi risk factor includ descemet membran endotheli keratoplasti procedur prior graft failur use sulfur hexafluorid gas factor reduc risk includ perform combin procedur use pre cut donor tissu pre oper laser iridotomi result help surgeon review practic pattern generat hypothes empir research regard origin graft detach
|
D005642;D057111
|
T061;T047
|
36,271,018
|
picomolar fluoresc probe compound affin determin carbon anhydras ix express live cancer cell numer human cancer especi hypox solid tumor express carbon anhydras ix caix transmembran protein catalyt domain locat extracellular space caix acidifi tumor microenviron promot metastas invas therefor consid promis anticanc target design seri high affin high select fluorescein label compound target caix visual quantifi caix express cancer cell competit bind model enabl determin common ca inhibitor dissoci constant caix express exponenti grow cancer cell test sulfonamid compound bound prolifer cell similar affin recombin purifi caix probe applic design select drug like compound caix competit strategi could appli drug target
|
D002256;D009369
|
T191;T126;T116
|
36,271,017
|
distanc distribut human microrna mirgenedb databas microrna mirna small singl strand non code rnas around nucleotid length found organ play import role cell differenti develop gene regul apoptosi distanc diseas mirna biomark use explor associ various diseas well associ virus diseas literatur date studi deriv distribut pairwis distanc human mirna pairwis distanc mirna biomark might use tool studi diseas associ paper distanc distribut human mirna deriv could use measur close mirna two distanc model use calcul pairwis distanc homo sapien mirna gene access mirgenedb databas mirna pairwis distanc fit normal distribut gamma distribut empir cumul distribut kernel densiti estim method first studi provid distanc distribut human mirna similar mirna biomark sever diseas examin use deriv distribut
|
D035683
|
T123;T114
|
36,271,016
|
microbi communiti resist suscept churra sheep infect teladorsagia circumcincta gastrointestin nematod gin major threat health welfar small rumin worldwid teladorsagia circumcincta nematod inhabit abomasum sheep especi temper region caus import econom loss given circumcincta microbiom share nich interact host expect although known within sheep breed anim resist other infect gin known microbiom influenc phenotyp anim condit sheep classifi accord cumul faecal egg count cfec end first experiment infect resist group rg suscept group sg circumcincta infect sheep experiment infect l circumcincta day day post infect euthan necropsi gastric mucosa gastric content abomasum collect extract bacteri dna sequenc v v region rrna gene use ilumina technolog bioanalysi perform result show divers divers remain similar group howev resist phenotyp sheep show higher number bacteria butyr ferment speci clostridium sensu stricto abund rg sg p turicibact abund rg sg p gastric content also serratia spp gastric mucosa abund rg sg p trend toward signific negat correl cfec clostridium sensu stricto abund gastric content detect r p data suggest microbiom composit could anoth factor associ develop resist phenotyp modifi interact host last instanc affect individu risk infect
|
D012757;D009348;D064307
|
T032;T204;T028;T047;T001
|
36,271,015
|
epigallocatechin gallat egcg allevi vascular dysfunct angiotensin ii infus hypertens mice modul oxid stress eno epigallocatechin gallat egcg shown antihypertens activ howev role epigallocatechin gallat egcg improv vascular function via modul endotheli nitric oxid synthas eno hypertens subject well research angiotensin ii infus hypertens mice week old receiv egcg mgkgday day via oral gavag arteri systol blood pressur sbp measur use tail cuff method everi three day end treatment vascular reactiv isol aorta studi use wire myograph level nitric oxid cyclic guanosin monophosph cgmp tetrahydrobiopterin bh determin use assay kit presenc protein nos p eno nox determin use western blot vivo treatment egcg day signific attenu increas sbp allevi vascular dysfunct increas vascular cgmp bh level well express p eno decreas elev ros level nox protein angiotensin ii infus hypertens mice collect treatment egcg hypertens mice exert blood pressur lower effect part attribut improv vascular function due abil reduc vascular oxid stress aortic tissu lead decreas eno uncoupl thus increas bioavail
|
D052250;D006973
|
T047;T126;T116
|
36,271,013
|
sleep decreas neuron activ control microgli dynam mice microglia brain resid immun cell high ramifi dynam process transient contact synaps contact report activ depend thorough studi yet especi physiolog condit investig neuron microglia contact microglia morphodynam mice activ depend context vigil state report microgli morphodynam microglia spine contact regul spontan evok neuron activ also found sleep modul microgli morphodynam cxcr signal synapt level microgli process attract toward activ spine wake relationship hinder sleep final microgli contact increas spine activ main nrem sleep altogeth result indic microgli function synaps depend neuron activ vigil state provid evid microglia could import synapt homeostasi plastic
|
D017628;D009474
|
T025
|
36,271,012
|
urban ecosystem drive genet divers feral honey bee urban chang biodivers direct posit negat despit rise global trend urban beekeep littl known impact urban genet divers honey bee investig urban affect genet variabl feral manag honey bee coloni spread throughout entir citi even high urban area genet analysi worker bee found convinc evid high genet differenti two group addit compar citi sampl sampl apiari rural part countri variat mitochondri trnaleu cox intergen region microsatellit loci indic feral coloni distinct pattern genet divers result evid feral honey bee find nich within high modifi human domin urban landscap lead us conclud urban driver genet divers feral honey bee citi
|
D017753;D012356
|
T123;T070;T082;T114
|
36,271,011
|
phase ii trial week nab paclitaxel progress symptomat desmoid tumor desmoid fibromatosi df mesenchym neoplasm potenti aggress cours relev clinic impact new system therapi modal need symptomaticprogress popul multicent phase ii trial nct patient symptomaticprogress df receiv three cycl week nab paclitaxel brief pain inventori short form bpi sf collect baselin everi visit mri perform everi month primari composit endpoint recist overal respons rate orr andor clinic respons improv point bpi sf patient achiev clinicalradiolog respons investig would warrant toxic progress free surviv pfs pattern respons correl clinic best respons bpi variat physic function analges consumpt secondari endpoint translat research report pre specifi secondari outcom forti elig patient start therapi radiolog clinic evalu studi achiev primari endpoint patient obtain recist partial respons wherea experienc pain reduct point bpi sf worst pain therapi well toler median follow month median month pfs rate ci ci clinic progress month pfs rate ci ci respect short cours nab paclitaxel activ safe achiev quick durabl respons progressingsymptomat df patient
|
D018222
|
T191
|
36,271,010
|
micro scale function modul human tempor lobe sensori cortic mani mammal often organ modul form cortic column yet whether modular organ spatial scale general properti human neocortex unknown strongest evid modular aris measur connect structur function converg use microelectrod record human examin function connect neuron spike respons order assess modular submillimet scale network find human tempor lobe consist tempor persist spatial compact modul approxim mm diamet function inform code singl neuron imag categor task similar neuron belong modul neuron differ modul geometri connect spike respons local cortic network provid converg evid human tempor lobe organ function modul micro scale
|
D013702;D010296
|
T023;T029;T030
|
36,271,009
|
investig lytic polysaccharid monooxygenas assist wood cell wall degrad microsensor lytic polysaccharid monooxygenas lpmo support biomass hydrolysi increas saccharif effici rate recent studi demonstr h rather cosubstr lpmo catalyz depolymer polysaccharid studi question physiolog relev h base mechan plant cell wall degrad studi report local time resolv determin lpmo activ poplar wood cell wall measur h concentr vicin piezo control h microsensor investig neurospora crassa lpmo bind inner cell wall layer consum enzymat generat h result point toward high catalyt effici lpmo low h concentr auxiliari oxidoreductas fungal secretom easili generat measur glucos microbiosensor addit demonstr lpmo promot cellobiohydrolas activ wood cell wall play synergist role fungal extracellular catabol industri biomass degrad
|
D006899;D014934
|
T126;T116;T167
|
36,271,008
|
develop cross nation investig model explain particip recommend placebo behaviour prevent covid infect protect covid peopl follow recommend author also resort placebo stop virus import understand factor under type prevent behaviour studi examin whether model develop base health belief model transact model stress explain particip recommend placebo action pandem model test sampl particip itali japan poland korea sweden us broad support object risk cue action show direct indirect perceiv threat associ prevent behaviour moreov locus control decis balanc health anxieti prevent cope moder relationship numer differ also found countri conclud belief control health perceiv benefit action critic develop intervent improv adher recommend
|
D000086382
|
T047;T067
|
36,271,007
|
retain kdo glycosyltransferas wbbb use doubl displac mechan intermedi adduct rearrang step wbbb lipopolysaccharid antigen synthesi enzym raoultella terrigena contain n termin glycosyltransferas domain high modifi architectur add termin kdo deoxi manno oct uloson acid residu antigen saccharid retent stereochemistri show use mass spectrometri wbbb form coval adduct catalyt nucleophil asp kdo also determin x ray structur cmp kdo donor complex kdo adduct dn dc wbbb variant synthet disaccharid acceptor complex ternari complex kdo adduct acceptor togeth structur show enzym link asp kdo adduct rotat reposit kdo second sub site transfer kdo acceptor retain glycosyltransferas thought use front side n substitut mechan show retain glycosyltransferas also potenti use doubl displac mechan incorpor addit catalyt subsit requir rearrang protein architectur
|
D016695;D008070
|
T126;T116;T109
|
36,271,006
|
spheroplast prepar boost catalyt potenti squalen hopen cyclas squalen hopen cyclas high valuabl attract class membran bound enzym sustain biotechnolog tool produc aroma bioactiv compound industri scale howev applic whole cell biocatalyst suffer outer cell membran act diffus barrier high hydrophob substrateproduct use purifi enzym lead dramat loss stabil present unexplor strategi biocatalysi applic squalen hopen cyclas spheroplast remov outer cell membran produc stabl substrat access biocatalyst spheroplast exhibit fold higher activ whole cell counterpart biotransform squalen geranyl aceton farnesol farnesyl aceton catalyt abil also higher purifi enzym high molecular weight terpen addit introduc concept carrier free immobil spheroplast via crosslink crosslink spheroplast crosslink spheroplast maintain catalyt activ spheroplast offer addit advantag recycl reus time solut contribut har catalyt potenti squalen hopen cyclas also make biocatalyt process even greener cost effici
|
D013185;D019751
|
T121;T116;T109;T126;T130
|
36,271,004
|
molecular insight distinct signal durat peptid induc pthr activ parathyroid hormon type receptor pthr class b g protein coupl receptor play critic role bone turnov ca homeostasi teriparatid pth abaloparatid abl term long act short act peptid respect regard mark durat distinct downstream signal howev mechanist detail remain obscur report cryo electron microscopi structur pth abl bound pthr gs complex adapt similar overal conform yet notabl differ receptor ecd region peptid c termin portion variabl analysi site direct mutagenesi studi uncov pth bound pthr gs complex display less motion toler mutat affect receptor signal abl bound complex furthermor combin structur analysi signal assay delin molecular basi differenti signal durat induc peptid studi deepen mechanist understand ligand mediat prolong transient signal
|
D044168;D019379
|
T125;T121;T116;T192
|
36,271,003
|
antibiot polymyxin arrang lipopolysaccharid crystallin structur solidifi bacteri membran polymyxin last resort antibiot potent activ multi drug resist pathogen interact lipopolysaccharid lps bacteri membran mechanist detail molecular level remain unclear character interact polymyxin nativ lps contain outer membran patch escherichia coli high resolut atom forc microscopi imag along structur biochem assay find polymyxin arrang lps hexagon assembl form crystallin structur format crystallin structur correl antibiot activ absent polymyxin resist strain crystal lattic paramet alter variat lps polymyxin molecul quantit measur show crystallin structur decreas membran thick increas membran area well stiff togeth find suggest format rigid lps polymyxin crystal subsequ membran disrupt mechan polymyxin action provid benchmark optim de novo design lps target antimicrobi
|
D011113;D004927
|
T047;T195;T116
|
36,271,001
|
long term monitor dataset fish assemblag rocki tidepool southern coast taiwan long term data fish assemblag collect rocki intertid zone provid valuabl resourc elucid tempor variat speci divers intertid ecosystem studi describ long term time seri dataset fish collect count number anesthet fish sampl station rocki tidepool southern coast taiwan speci assemblag monitor season two station total sampl contain individu belong speci record data use elucid tempor variat fish assemblag intertid ecosystem background inform resili fish communiti conserv coastal area current studi present valuabl data research understand tempor spatial variat speci abund rich divers composit relat climat chang environment factor human activ
|
D017753;D005399
|
T070;T082;T013
|
36,271,000
|
ct cone beam ct ablat radiat therapi pancreat cancer expert organ risk contour describ dataset patient receiv ablat radiat therapi local advanc pancreat cancer lapc consist comput tomographi ct cone beam ct cbct imag physician drawn organ risk oar contour imag dataset one ct treatment plan two cbct scan time treatment per patient collect patient scan acquir patient treatment posit deep inspir breath hold state six radiat oncologist delin gastrointestin oar consist small bowel stomach duodenum physician delin imag set belong patient two train medic physicist edit contour ensur adher delin guidelin imag contour file avail dicom format public avail cancer imag archiv https doiorgtciaeshq version dataset serv criterion standard evalu accuraci reliabl deform imag registr auto segment algorithm well train set deep learn base method
|
D010190;D011880
|
T061;T191
|
36,270,999
|
understand relationship asthma medic use outcom sabina primari care databas studi adher inhal corticosteroid ic asthma suboptim patient may reli short act beta agonist saba control symptom may increas risk exacerb uncontrol asthma object describ ic adher saba use among dutch primari care patient asthma relat exacerb self report asthma control patient age year diagnos asthma receiv inhal medic prescript select nivel primari care databas ic adher continu measur medic avail saba use number prescript exacerb short cours oral corticosteroid daili dose mg asthma control self report asthma control questionnair acq comput multilevel logist regress analys account cluster patient within practic use model associ ic adher saba use asthma outcom prescript data patient includ ic adher averag sd patient receiv saba prescript patient experienc exacerb self report asthma control avail patient report control asthma acq score ic adher associ exacerb whilst poor ic adher associ uncontrol asthma conclus increas saba use import easili identifi signal general practition discuss asthma self manag behavior patient
|
D001249;D018927
|
T121;T047
|
36,270,998
|
ten year databas cancer mortal rate itali itali approxim new case malign tumor record everi year averag annual death caus tumor accord italian cancer regist death per men women respect total death everi peopl long term least decad spatial detail data municip scale neither easili access fulli avail public consult citizen scientist research group associ therefor present ten year databas cancer mortal rate form standard mortal ratio smr cancer macro type itali municip provinci region scale aim make easili access comprehens readi use open access sourc data updat status cancer mortal itali local nation stakehold research policymak provid research readi use data perform specif studi
|
D009369
|
T191
|
36,270,994
|
cholesterol transport protein gramdc regul autophagi initi mitochondri bioenerget autophagi cytosol cargo sequest doubl membran vesicl call autophagosom contribut specif lipid cholesterol membran form autophagosom remain fulli character demonstr short term cholesterol deplet lead rapid induct autophagi correspond increas autophagi initi event show er local cholesterol transport protein gramdc function negat regul starvat induc autophagi cholesterol transport vast domain membran bind gram domain requir gramdc mediat suppress autophagi initi similar yeast orthologu gramdc associ mitochondria gram domain cell lack gramdc vast domain show increas mitochondri cholesterol level mitochondri oxid phosphoryl suggest gramdc may facilit cholesterol transfer er mitochondria contact site final demonstr express gramd famili protein link clear cell renal carcinoma surviv highlight pathophysiolog relev cholesterol transport protein
|
D002352;D001343
|
T123;T116;T043
|
36,270,993
|
translat reprogram respons accumul stressor ensur critic threshold level hsp mammalian life cytosol molecular chaperon hsp essenti eukaryot life although reduc hsp level correl age unknown whether eukaryot cell organ tune basal hsp level allevi physiolog accumul stress investig whether mice adapt delet three four allel two gene encod cytosol hsp one hsp allel remain one vast major mous embryo die gestat survivor appar manag increas hsp protein least wild type level studi reveal intern ribosom entri site untransl region hsp mrna allow translat reprogram compens genet loss hsp allel respons stress find minimum amount total hsp requir support viabil mammalian cell organ normal fail maintain threshold level subject acceler senesc proteostat collaps ultim death therefor consid hsp level reduc fold unicellular bud yeast critic threshold level hsp mark increas eukaryot evolut
|
D000067556;D018841
|
T123;T116;T086
|
36,270,992
|
lactos azocalixaren drug deliveri system treatment multidrug resist pseudomona aeruginosa infect diabet ulcer diabet wound one intract chronic wound prone bacteri infect hypoxia import featur microenviron howev challeng antimicrobi therapi direct appli exist hypoxia respons drug deliveri system due activ target defici biofilm obstacl herein custom hypoxia respons carrier lactos modifi azocalix aren lacaca abil activ target inhibit biofilm load ciprofloxacin cip result supramolecular nanoformul cip lacaca demonstr enhanc antibacteri efficaci result increas drug accumul control releas site infect appli diabet wound togeth multidrug resist pseudomona aeruginosa infect vivo cip lacaca induc definit less inflammatori infiltr free cip translat high wound heal perform import design principl provid direct develop antimicrobi drug deliveri system
|
D000890;D011552;D003920
|
T121;T047
|
36,270,991
|
long term whole blood dna preserv cost effici cryosilicif deoxyribonucl acid dna blueprint life cost effect method long term storag could mani potenti benefit societi present method situ cryosilicif whole blood cell allow long term preserv dna import straightforward approach inexpens reliabl yield cryosilicifi sampl fulfil essenti criteria safe long term dna preserv name robust extern stressor radic oxygen speci ultraviolet radiat long term stabil humid condit elev temperatur approach could enabl room temperatur storag genom inform book size format one thousand year thermal equival cost person addit demonstr print dna bank artefact could potenti allow artifici fossil
|
D014466;D004247
|
T123;T070;T114
|
36,270,990
|
global map galnac isoform specif glycosyl site occup tissu form human cell line mucin type glycosyl protein integr involv human health diseas coordin enzym famili n acetylgalactosaminyltransferas galnac ts detail knowledg biolog effect site specif glycosyl limit due lack inform specif glycosyl enzym activ glycosyl site occup present systemat analysi isoform specif target galnac ts express within tissu form human skin cell line demonstr biolog signific effect glycan initi epitheli format find uniqu glycosyl site across divers set protein specif regul one galnac isoform consist impact tissu phenotyp notabl discov high variabl glycosyl site occup glycosyl region secret protein find revisit relev individu glycosyl site proteom provid approach establish site drive biolog function
|
D020543;D017350
|
T123;T126;T116
|
36,270,989
|
e ubiquitin ligas rnf attenu patholog cardiac hypertrophi sting ring finger protein rnf e ubiquitin ligas express varieti human tissu rnf involv regul endoplasm reticulum stress inflamm innat immun play import role occurr develop various tumor howev role rnf cardiac hypertrophi report studi found express rnf increas heart mice patholog cardiac hypertrophi loss function research demonstr rnf defici exacerb cardiac hypertrophi wherea gain function studi reveal overexpress rnf opposit effect stimul interferon gene sting signal molecul activ type interferon immun medit inflamm immun respons mani diseas protein protein interact experi confirm sting interact rnf studi show rnf inhibit cardiac hypertrophi promot sting degrad k link polyubiquitin therefor defin rnf import regul signal cardiac hypertrophi
|
D007370;D044767
|
T129;T121;T126;T116
|
36,270,986
|
hdac depend deacetyl tak enhanc sil r releas promot macrophag polar colon cancer histon deacetylas hdac member hdac famili identifi potenti therapeut target tumor therapi function under mechan hdac colon cancer incomplet character studi show infiltr ratio macrophag increas colon cancer tissu high hdac express similar knockdown hdac colon cancer cell inhibit cocultur macrophag polar vitro analysi antibodi chip reveal hdac promot sil r releas enhanc macrophag polar mass spectrometri immunoprecipit demonstr mechanist hdac interact transform growth factor activ kinas tak deacetyl tak promot tak phosphoryl tak p mapk signal could increas phosphoryl activ adam respons shed il r notabl express phosphoryl tak posit correl hdac express macrophag polar human colon cancer tissu studi reveal new hdac tak adam regulatori axi mediat sil r releas macrophag polar colon cancer
|
D003110
|
T191
|
36,270,985
|
divers matur depend complementari anti apoptot brake safeguard human ipsc deriv neuron cell death human neuron born embryon develop persist throughout entir lifespan individu thus human neuron develop elabor surviv strategi protect accident cell death set deciph development adapt result neuron resili demonstr time cours matur human neuron instal complex complementari anti apoptot signal network includ downregul central protein intrins apoptosi pathway includ sever caspas ii shift ratio pro anti apoptot bcl famili protein iii elabor regulatori network result upregul inhibitor apoptosi protein iap xiap togeth adapt strong increas threshold apoptosi initi confront wide rang cellular stressor result highlight human neuron endow complex redund preemptiv strategi protect stress cell death
|
D057026
|
T025
|
36,270,984
|
histon methyltransferas smyd drive adipogenesi via regul stat phosphoryl adipogenesi complex cascad involv preadipocyt differenti toward matur adipocyt acceler onset obes histon methyltransferas set mynd domain contain protein smyd involv varieti cellular biolog function epigenet regul smyd adipogenesi adipocyt differenti remain unclear smyd sirna lli inhibitor smyd use examin effect smyd adipogenesi adipocyt differenti vitro smyd heterozyg knockout smyd mice also construct valid relationship smyd adipogenesi vivo found smyd abund white adipos tissu close correl adipocyt differenti knockdown inhibit smyd restrain adipocyt differenti vitro requir phosphoryl stat vivo function valid smyd mice exert signific fat loss suscept hfd induc obes taken togeth find reveal smyd novel regul adipocyt differenti regul phosphoryl stat provid insight effect epigenet regul adipogenesi inhibit smyd might repres viabl strategi anti adipogenesi mayb allevi obes relat diseas human
|
D044127;D009765
|
T045;T047
|
36,270,983
|
nlrp requir cancer deriv exosom modifi macrophag polar promot metastasi small cell lung cancer metastasi remain primari caus small cell lung cancer sclc relat death grow evid link tumor metastasi pre metastat microenviron character anti inflammatori respons immunosuppress presenc tumor deriv exosom clarifi relationship among factor sclc analyz sclc patient sampl well mous model among infiltr immun cell studi focus tumor associ macrophag tam well known promot tumor progress metastasi found high express altern activ tam marker cd associ clinic poorer prognosi metastasi state patient sclc moreov infiltr macrophag found metastat foci sclc mous model addit observ domin switch phenotyp accompani increas nlrp express sinc tumor deriv exosom key link tumor immun microenviron investig whether sclc deriv exosom contribut phenotyp switch find show first time sclc deriv exosom induc switch via nlrpnf b pathway thus promot sclc metastasi vitro vivo collect result indic novel mechan sclc deriv exosom induc immunosuppress distant promot system metastasi activ nlrp highlight close relationship tumor deriv exosom inflammasom immun microenviron sclc metastasi
|
D055354;D008175;D055752
|
T026;T191
|
36,270,982
|
tnfr ubch axi drive lung squamous cell carcinoma dedifferenti metastasi cell autonom signal loop tumor necrosi factor receptor tnfr encod tnfrsfa critic transduc inflammatori pathway physiolog role human cancer complet understood observ high express tnfr mani human lung squamous cell carcinoma sccs sampl spontan lung sccs deriv kinas dead ikk knock kaka mice knock tnfrfa kaka mice block lung scc format inject via tail vein kal lu lung scc cell high express tnfrtnf sox c myc twist bcl ubch generat dedifferenti spindl cell carcinoma epitheli mesenchym transit marker mous lung contrast kal lu cell silenc tnfr kal lu cell express low level tnfr generat well differenti lung sccs less tumorigen metastat identifi downstream effector tnfr oncogen ubch e ubiquitin conjug enzym target includ twist c myc sox enhanc scc cell dedifferenti furthermor tg ktnfr kaka mice express transgen tnfr keratin positv epitheli cell develop poor differenti metastat lung sccs found kaka mice find demonstr overexpress tnfr ubch axi advanc lung carcinogenesi metastasi dedifferenti mechan constitu pathway may contribut develop differenti relat therapi lung scc
|
D002294;D002289;D008175
|
T191
|
36,270,981
|
epstein barr virus mediat transform b cell xiap defici patient lead increas express tumor suppressor cadm x link lymphoprolif diseas xlp either caus loss slam associ protein sap xlp x link inhibitor apoptosi xiap xlp instanc infect oncogen human epstein barr virus ebv lead patholog ebv associ lymphoma emerg xlp patient therefor investig role xiap b cell transform ebv use human mice iap inhibit ebv infect mice led loss b cell tendenc lower viral titer lymphomagenesi loss memori b cell also observ four newli describ patient xiap defici ebv abl transform b cell lymphoblastoid cell line lcls similar growth characterist patient mother lcls vitro vivo gene express analysi reveal modest elev lytic ebv gene transcript well express tumor suppressor cell adhes molecul cadm cadm express ebv infect b cell might therefor inhibit ebv associ lymphomagenesi patient result absenc ebv associ malign xlp patient
|
D020031;D008232
|
T047;T191
|
36,270,980
|
accumul mir b p indispens effici erythroblast enucl erythroblast enucl precis regul clear understood process polycythemia show patholog erythroblast enucl discov low mir b p level termin erythroblast patient polycythemia vera pv compar healthi control exogen upregul mir b p level restor enucl rate normal level direct downregul mir b p mous erythroblast simul enucl issu found patient pv mir b p accumul found enucl erythroblast collect suggest import mir b p accumul erythroblast enucl elucid role mir b p enucl gain loss function studi perform overexpress mir b p improv enucl erythroleukemia cell primari erythroblast infus erythroblast higher level mir b p also exhibit acceler enucl contrast mir b p inhibitor signific suppress erythrocyt enucl intracellular imag reveal addit cytoskelet assembl nuclear condens mir b p overexpress result mitochondri reduct depolar real time pcr western blot analysi luciferas report assay small molecul inhibitor supplement gene rescu assay reveal bcl direct target mir b p one key mediat mir b p enucl follow suppress bcl activ caspas subsequ activ rock result cytoskelet rearrang enucl conclus studi first reveal pivot role mir b p erythroblast enucl
|
D035683
|
T123;T114
|
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