PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,270,508
|
protein prefer elev plasma fgf induc dietari protein restrict similar male femal mice anim moder protein restrict respond dietari stress increas consumpt protein contain food true mani speci includ rodent rodent model protein restrict typic reli male subject plausibl reason femal rodent may respond differ dietari protein restrict address gap knowledg current experi examin protein prefer two week protein diet protein control diet male femal mice found femal protein restrict mice like male protein restrict mice increas consumpt casein protein relat maltodextrin carbohydr present simultan interest increas consumpt due burst femal lick per burst male indic possibl differ mechan increas intak achiev stage estrous cycl affect femal respons moreov measur plasma fibroblast growth factor fgf hormon induc protein restrict necessari protein prefer male femal mice found statist differ protein restrict male femal diestrus femal proestrus non restrict mice fgf level low signific higher femal proestrus femal diestrus male overal experi highlight import includ femal subject studi food choic macronutri restrict
|
D018753;D005346
|
T061;T123;T116
|
36,270,506
|
contactless skin perfus monitor video camera track pharmacolog vasoconstrict vasodil use photoplethysmograph chang object clinic assess skin perfus inform prognosi critic ill patient video camera monitor could provid object continu method monitor skin perfus prospect intervent studi healthi volunt test whether video camera deriv photoplethysmographi imag colour measur could detect drug induc skin perfus chang approach monitor lower limb volunt use video camera administ phenylephrin vasoconstrictor glyceryl trinitr vasodil report relat pixel intens chang baselin absolut valu sensit environment factor primari outcom pre peak infus green channel amplitud chang pulsatil ppgi waveform compon secondari outcom pre peak chang photoplethysmograph imag waveform baselin skin colour hue skin colour satur main result particip median age year iqr sixteen male p mean decreas amplitud pulsatil photoplethysmograph imag waveform occur follow phenylephrin infus p mean increas occur follow glyceryl trinitr infus photoplethysmograph imag baselin decreas phenylephrin p increas glyceryl trinitr p skin colour hue chang opposit direct phenylephrin p glyceryl trinitr p skin colour satur decreas phenylephrin p signific chang observ glyceryl trinitr p signific drug induc vasoconstrict vasodil associ detect chang photoplethysmograph imag waveform paramet skin hue find suggest video camera great potenti continu contactless skin perfus monitor
|
D005996;D014664
|
T121;T073;T042;T109
|
36,270,505
|
time frequenc analysi brain activ respons direct non direct visual stimuli event relat spectral perturb ersp studi object larg part cerebr cortex dedic process visual stimuli still much understand process modal hierarchi main aim present studi investig differ direct visual stimuli ds non direct visual stimuli n ds process time frequenc analysi brain electroencephalograph activ visuo motor task electroencephalographi eeg data divid four region interest roi frontal central pariet occipit approach analysi visual stimuli process base combin electroencephalograph record time frequenc analysi event relat spectral perturb ersp comput spectrum analysi allow obtain averag time cours relat chang induc stimulus present spontan eeg amplitud spectrum main result visual stimuli process enhanc pattern spectral modul investig roi differ amplitud time addit statist signific differ occipit roi ds n ds visual stimuli process theta alpha beta band found signific evid suggest ersp could use tool investig encod visual inform differ brain region simplic capabl represent brain activ ersp might use biomark function recoveri exampl rehabilit visual dysfunct motor impair follow stroke well diagnost tool anomali brain function neurolog diseas tailor person treatment clinic environ
|
D004569;D009424
|
T060;T039;T034;T042
|
36,270,503
|
bioinspir apparatus model peristalt pump biophys flow studi present novel bioinspir experiment apparatus construct data acquisit methodolog valid studi peristalt flow apparatus consist seri stepper motor actuat deflect deform membran produc peristalt flow show apparatus design signific advantag previous design use studi peristalt flow offer much wider rang model capabl comparison capabl apparatus previous one show apparatus span larger rang wavelength wave speed c amplitud waveform ie apparatus constrain nondispers wave sinusoid shape larg paramet rang make apparatus use tool biomimet experiment model particular system complex waveform peristalt flow perivascular vessel arteri cochlea urethra provid detail experiment design construct eas reconstruct reader apparatus capabl valid larg paramet rang compar experiment measur analyt result ibanez et al phys rev fluid high reynold number jaffrin shapiro annu rev fluid mech low reynold number applic show apparatus use biophys peristalt studi potenti applic type studi
|
D008954;D010528
|
T075;T042
|
36,270,502
|
introduc block toeplitz covari matric remast linear discrimin analysi event relat potenti brain comput interfac object covari matric noisi multichannel electroencephalogram eeg time seri data provid essenti inform decod brain signal use machin learn method howev small dataset high dimension make hard estim matric brain comput interfac bci base event relat potenti erp linear discrimin analysi lda classifi state art covari estim use shrinkag regular general covari regular approach aim improv lda better exploit domain specif characterist eeg regular covari estim approach propos enforc block toeplitz structur covari matrix lda implement assumpt signal stationar short time window channel main result offlin analysi data collect subject differ event relat potenti bci protocol show signific increas binari classif perform toeplitzlda compar shrinkag regular lda auc point p riemannian classif approach auc point p unsupervis visual speller applic improv would translat relat reduct spell error averag subject addit asid lower memori reduc time complex lda train toeplitzlda prove robust drastic increas number tempor featur signific propos covari estim allow bci research improv classif rate reduc calibr time bci protocol use event relat potenti thus support usabl correspond applic lower comput memori need could make valuabl algorithm especi mobil bcis
|
D062207
|
T074
|
36,270,501
|
forecast psychogen non epilept seizur likelihood ambulatori eeg ecg object critic slow featur varianc autocorrel long term continu electroencephalographi eeg electrocardiographi ecg data previous use forecast epilept seizur onset studi test feasibl forecast non epilept seizur use method examin long term cycl brain cardiac activ present clinic physiolog record psychogen non epilept seizur pnes approach retrospect access ambulatori eeg ecg data patient non epilept seizur background epilepsi use develop forecast system median period record h median non epilept seizur per patient phase differ cycl min h h h h eeg rr interv rri critic slow featur investig forecast generat use combin varianc autocorrel eeg rri ecg aforement cycl length optim forecast select highest area receiv oper curv auc main result found pnes event occur rise phase eeg featur cycl h durat rate signific chanc demonstr propos forecast achiev perform signific better chanc patient mean auc best forecast across patient signific knowledg first studi retrospect forecast non epilept seizur use eeg ecg data signific eeg forecast model suggest cyclic eeg featur non epilept seizur exist studi open potenti seizur forecast beyond epilepsi disord episod loss conscious dissoci
|
D012640;D004827
|
T033;T184;T047;T046
|
36,270,467
|
subject adapt convolut neural network eeg base motor imageri classif object deep transfer learn wide use address nonstationar electroencephalogram eeg data motor imageri mi classif howev previous deep learn approach suffer limit classif accuraci tempor spatial featur effect extract approach propos novel end end deep subject adapt convolut neural network sacnn handl problem eeg base mi classif propos model joint optim three modul ie featur extractor classifi subject adapt specif featur extractor simultan extract tempor spatial featur raw eeg data use parallel multiscal convolut network addit design subject adapt reduc featur distribut shift sourc target subject use maximum mean discrep minim classif loss distribut discrep model abl extract tempor spatial featur predict new subject main result extens experi carri three eeg base mi dataset ie brain comput interfac bci competit iv dataset iib bci competit iii dataset iva bci competit iv dataset averag accuraci reach three dataset respect furthermor statist analysi also indic signific perform improv sacnn signific paper reveal import tempor spatial featur eeg base mi classif task propos sacnn model make fulli use tempor spatial inform achiev purpos
|
D062207
|
T074
|
36,270,452
|
defici cd exacerb inflamm induc activ migrat bv microglia regul taknf b pathway role cd inflammatori respons report multipl previous studi howev under mechan cd microgli activ migrat neuroinflamm post spinal cord injuri sci remain elus current studi perform western blot qrt pcr immunofluoresc analys transwel assay elisa determin express chang depth molecular mechan cd microglia post inflammatori initi found cd express increas microglia sci vivo lipopolysaccharid lps stimuli vitro addit cd interact tak inhibit nf b activ thus attenu inflamm migrat microglia treatment lps find indic cd might particip microglia induc neuroinflamm develop post sci suggest cd promis target neuroimmunolog regul
|
D016328;D013119
|
T129;T116;T037
|
36,270,451
|
probe chang brain esterifi oxylipin concentr earli stage pathogenesi alzheim diseas transgen rat despit known patholog hallmark alzheim diseas ad includ neuron loss gliosi inflamm beta amyloid plaqu deposit neurofibrillari tangl accumul brain littl known inflamm resolut earli ad pathogenesi brain inflamm resolut pathway mediat free oxylipin most bound ie esterifi therefor must releas ie becom free exert bioactiv recent show reduct brain esterifi pro resolv oxylipin transgen rat model ad tgf ad rat month age suggest deficit sourc avail free pro resolv oxylipin present studi test whether chang discern earlier diseas process ie age month observ signific reduct esterifi pro resolv epoxyeicosatrieno acid epetr hydroxyoctadecatrieno acid hotr hydroxyeicosapentaeno acid hepe oxylipin pro inflammatori hydroxi octadecadieno acid hode hydroxi eicosatetraeno acid hete deoxi prostaglandin j deoxi pgj prostaglandin e pge oxylipin male andor femal transgen ad rat compar wildtyp control find point deficit esterifi pro resolv lipid mediat earli stage ad concid chang esterifi lipid mediat involv promot inflamm
|
D000544
|
T047;T048
|
36,270,422
|
fabric scaffold free mesenchym tissu band cell self aggreg techniqu potenti use tissu regener three dimension cell construct compris tissu specif cell extracellular matrix secret would ideal transplant fabric cell aggreg manner without cell scaffold reli random cell self aggreg make control size shape difficult studi propos method fabric band shape tissu induc self aggreg cell sheet use develop cell self aggreg techniqu cat act cell aggreg stopper silicon semicircular pillar attach two posit equidist short end round rectangular cultur groov coat specif charg biomimet polym cat induc surfac mesenchym stem cell chondrocyt skelet myoblast cell seed surfac cultur groov form band shape aggreg two aggreg stopper follow spontan detach aggreg cell sheet outer edg groov day one cultur aggreg chondrocyt band matur cartilag like plate abund cartilag matrix retain band shape two week chondrogen cultiv addit aggreg mesenchym stem cell myoblast cell band could patch induc collagen membran deriv rat subcutan tissu like bandag immedi format success matur fat muscl tissu respect result indic depend cell type scaffold free band shape cell aggreg produc cat potenti achiev tissu regener follow shape defect via vitro matur cultur vivo organ
|
D020219;D059630
|
T025;T042
|
36,270,397
|
engin superwet membran spider web structur carboxymethyl cellulos gel layer effici oil water separ base biomimet concept superhydrophil underwat superoleophob membran recent attract signific interest materi effect oil water emuls separ work superwet membran spider web structur gel layer design effici oil water separ biomateri carboxymethyl cellulos cmc use raw materi spider web structur gel layer construct pvdf membran surfac heat treatment chemic cross link hydrophil gel layer impart excel superhydrophil underwat superoleophob properti membran special spider web structur improv membran mechan stabil fabric membran exhibit superhydrophil underwat superoleophob among differ cmc concentr modifi membran membran contain wt cmc exhibit flux lm h dichloromethan oil water emuls separ fold higher pristin pvdf membran membran show effici oil water separ capac addit water flux recoveri reach high oil reject attain meanwhil spiderweb structur gel layer membran surfac display good mechan stabil summari novel membran modif method inspir spider web structur simpl cost effect environment friend therebi make promis futur prepar high effici oil water emuls separ membran
|
D002266;D013112
|
T121;T204;T109
|
36,270,388
|
green hydrogen product consolid bioprocess lignocellulos biomass use nanobiotechnolog approach main object studi develop sustain process hydrogen product implement nanotechnolog combin consolid bioprocess cbp approach lignocellulos biomass lcb peroxidas mimick cefe nanoparticl nps gl appli degrad lignin raw corn cob cc biomass generat cellulos hemicellulos fraction amen toward clostridium cellulovoran ferment process np treat biomass exhibit lignin remov raw cc employ hydrogen ferment c cellulovoran cbp method strain yield maximum ml cumul hydrogen hydrogen product rate mlh use np treat cc best knowledg first studi enhanc hydrogen product use np treat cc biomass singl pot ferment prove simpler easier econom process
|
D008031;D006859
|
T123;T196;T109
|
36,270,387
|
catalyt pyrolysi upgrad silver grass miscanthus sinensi carbon dioxid flammabl gase studi propos sustain hydrogen product platform use fast grow ined biomass wast silver grass miscanthus sinensi pyrolysi silver grass wast sgw investig use co co feedstock focus distribut hydrogen differ product catalyst absent hydrogen element distribut h gas pyrolysi sgw c reach wt pyrolysi nisio catalyst wt hydrogen convert h gas wt hydrogen distribut gaseous hydrocarbon c owe addit co co product promot catalyt convers co volatil matter notabl co proven use reactant produc valu ad co thus catalyt pyrolysi presenc co consid renew approach produc flammabl gase mitig co emiss
|
D002245;D006109;D000077319
|
T123;T197;T070;T002
|
36,270,347
|
pathophysiolog clinic aspect circadian rhythm arteri stiff diabet mellitus minireview sever cross section trial reveal increas arteri stiff connect cardiac autonom neuropathi type diabet patient pathophysiolog relationship arteri stiff autonom dysfunct diabet mellitus still underinvestig question whether presenc cardiac autonom neuropathi lead arteri stiffen increas arteri stiff induc autonom nervous system impair still open arteri stiff dysfunct autonom nervous system common pathogenet pathway count state chronic hyperinsulinemia hyperglycemia increas format advanc glycat end product activ protein kinas c develop endotheli dysfunct chronic low grade inflamm baroreceptor dysfunct thought one possibl reason arteri wall stiffen develop progress contrari violat autonom nervous system function affect vascular tone way alter larg arteri wall elast properti anoth possibl mechan attach andor develop arteri stiff increas heart rate autonom dysfunct correspond progress minireview analyz current state relationship diabet mellitus arteri stiff particular attent paid analysi interpret applic result obtain patient type diabet mellitus diabet cardiac autonom neuropathi
|
D059289;D003924;D001342;D003929
|
T047;T046
|
36,270,346
|
associ mental health obes postmenopaus women systemat review postmenopaus women great risk mental health deterior may lead morbid mortal decrement mental health age attribut hormon chang lower physic activ sleep disturb econom factor well modifi variabl smoke obes studi shown controversi result associ obes mental health postmenopaus women studi systemat review evid avail associ obes mental health postmenopaus women aim identifi reliabl obes measur shown associ mental health well effect measur practic improv mental health postmenopaus obes women cinahl scopus scienc direct pubm includ medlin databas search articl studi averag good qualiti includ cross section intervent studi show posit associ obes deterior mental health show negat associ two show associ intervent studi show posit two signific impact intervent use obes mental health conclus studi show posit associ obes especi viscer obes mental health issu particular depress anxieti sleep disord combin calor restrict exercis seem better impact mental health postmenopaus comparison intervent
|
D008603;D017698
|
T040;T041
|
36,270,345
|
rare case poor differenti mix neuroendocrin nonneuroendocrin tumor caecum long term surviv case report year old woman present flush attack accompani tachycardia hypotens last approxim minut underw year ago gastrointestin tumor resect histolog examin reveal poor differenti mix neuroendocrineadenocarcinoma locat caecum region metastas postop patient receiv combin chemotherapi fluorouracil interferon six month sinc remain asymptomat examin reveal posit chromogranin cga fetoprotein afp ng h normal rang iuml normal rang respect urinari hydroxi indol acet acid excret remark high mg h normal rang mg h abdomin magnet reson imag scan reveal multipl focal loci liver whose histolog examin reveal carcinoid tumor confirm octreoscan addit uptak note right shoulder right sternum clavicl joint confirm tc mdp scan patient receiv somatostatin analogu therapi follow long act releas octreotid analogu therapi mgmonth show partial improv relev biomark two year later carcinoid syndrom symptom reappear due tumor express somatostatin receptor patient receiv peptid receptor radionuclid therapi lu dotat result clinic biochem improv
|
D015282;D018358
|
T125;T121;T191;T116
|
36,270,344
|
assess diagnost perform mg dexamethason suppress test class obes patient object studi aim evalu preval cush syndrom diagnost perform mg dexamethason suppress test class obes patient method anthropometr measur laboratori data includ mg dexamethason suppress test class obes patient appli endocrinolog metabol outpati clinic pre bariatr surgeri evalu evalu retrospect result abnorm respons mg dexamethason suppress test cortisol mcgdl observ patient presenc cush syndrom confirm addit test patient preval abnorm dexamethason suppress test preval cush syndrom specif valu determin mg dexamethason suppress test cortisol threshold valu mcgdl conclus preval cush syndrom found low class obes patient mg dexamethason suppress test suffici perform cush syndrom screen patient group
|
D003480
|
T047
|
36,270,343
|
interplay cardiovascular thyroid dysfunct review clinic implic manag strategi cardiovascular diseas cvd thyroid dysfunct two prevail disord world close interlink action thyroid hormon mediat via thyroid receptor present myocardium vascular tissu primari mechan link thyroid dysfunct cvd modif cardiovascular risk factor dyslipidemia blood pressur coagul paramet etc result endotheli left ventricular systol diastol dysfunct overt subclin hyperthyroid hypothyroid may caus advers alter cardiac function hyperthyroid give rise palpit atrial fibril systol hypertens heart failur wherea hypothyroid increas diastol hypertens pericardi effus risk ischem heart diseas via alter lipid coagul paramet earli recognit treatment thyroid dysfunct may prevent advers cardiovascular event patient without pre exist cvd certain cardiac condit medic caus alter thyroid function may predispos individu higher morbid mortal certain situat thyroid dysfunct treatment may cardiovascular benefit studi deal interplay cardiovascular thyroid dysfunct associ clinic implic manag strategi
|
D006980;D007037;D013959;D002318;D006973
|
T047
|
36,270,342
|
ern depend impact glutamin glucos depriv pyruv dehydrogenas gene express glioma cell object aim present studi investig express pyruv dehydrogenas gene pdha pdhb dlat dld pdhx u glioma cell respons glutamin glucos depriv control glioma cell endoplasm reticulum nucleus signal ern knockdown cell major endoplasm reticulum er stress signal pathway find whether exist possibl depend import regulatori gene express glutamin glucos suppli well ern signal method express level pdha pdhb dlat dld pdhx gene studi real time quantit polymeras chain reaction control u glioma cell transfect empti vector cell inhibit ern transfect dnern cell exposur glucos glutamin depriv result data show express level pdha pdhb dlat dld gene regul profound pdhb gene control glioma cell treat glutamin depriv time ern knockdown modifi impact glutamin depriv express level gene glioma cell suppress sensit pdhb dld gene express remov impact glutamin depriv express pdha dlat gene glucos depriv signific chang express level studi gene control glioma cell ern knockdown suppress impact glucos depriv pdhx dld gene express signific enhanc express pdha pdhb gene signific chang observ sensit pdhx gene express glutamin depriv neither control ern knock glioma cell knock ern remov sensit dlat gene express glucos depriv conclus result investig demonstr exposur control u glioma cell glutamin depriv signific affect express pdha pdhb dlat dld gene gene specif manner impact glutamin depriv modifi inhibit er stress signal mediat ern time glucos depriv affect express pdha pdhb pdhx dld gene ern knockdown glioma cell thus express pyruv dehydrogenas gene glutamin glucos depriv condit appear control er stress signal ern
|
D005973;D005910
|
T123;T121;T191;T116
|
36,270,341
|
prolactinoma patient react favor cabergolin medic object prolactinoma common endocrin disord frequent type pituitari tumor act primarili suppressor gonad function general success treat dopamin agonist howev treatment resist still remain unneglect ratio studi aim identifi factor may play role treatment respons method seventi six patient prolactinoma routin follow istanbul research educ hospit endocrinolog outpati clinic includ studi initi prolactin level adenoma size baselin weight bodi mass index bmi glucos high densiti lipoprotein hdl cholesterol low densiti lipoprotein ldl cholesterol triglycerid level obtain patient medic record patient divid two group treatment respond non respond refractori one accord treatment respons durat suggest guidelin treatment respond non respond group compar accord initi rd month prolactin level adenoma size weight bmi metabol valu result initi tumor diamet mm refractori mm treatment respond group p refractori group higher prolactin baselin level gl vs gl respond group p refractori group higher rd month prolactin level gl vs gl respond group p refractori group higher frequenc cystichemorrhag adenoma n p baselin pituitari failur n p baselin cavern sinus invas n p treatment respond group lower initi bodi weight kg vs kg p lower bmi kgm vs kgm p conclus studi initi tumor size male gender weight bmi rd month prolactin level initi pituitari defici cystichemorrhag compon pituitari imag patient prolactinoma associ lower treatment respons
|
D015175;D010911;D000236
|
T191
|
36,270,340
|
impact type diabet durat serum asymmetr dimethylarginin c reactiv protein concentr bosnian patient object present studi assess impact type diabet mellitus tdm durat serum asymmetr dimethylarginin adma c reactiv protein crp concentr bosnian patient method particip cross section studi random select famili medicin clinic sarajevo bosnia herzegovina serum adma concentr determin elisa serum high sensit hs crp determin particl enhanc immunonephelometri anova test follow scheff post hoc test kruskal walli test follow man whitney test use statist analysi result studi includ patient year diabet durat year tdm group patient greater year diabet durat year tdm group control serum adma concentr year tdm group moll signific higher compar serum adma concentr year tdm group moll p control moll p signific differ serum adma concentr found year tdm group control p year tdm group mgl signific higher compar serum crp concentr year tdm group mgl p control mgl p signific differ serum crp concentr observ year tdm group control p conclus present studi show increas serum adma crp concentr advanc tdm result suggest adma crp may serv indic endotheli dysfunct chronic low grade inflamm progress patient tdm larger prospect studi requir confirm observ find
|
D002097;D003924
|
T129;T047;T116
|
36,270,331
|
separ phosphorothio oligonucleotid impur wax hplc high organ content elut condit separ impur phosphorothio diester ps oligonucleotid complic presenc larg number diastereoisom eg mer oligonucleotid peak broaden due hydrophob charact sulfur atom chemic similar impur parent oligonucleotid difficulti aris due chemic natur oligonucleotid display complex mixtur ionic hydrophob h bond function minim hydrophob interact peak broaden due ps modif develop novel method combin weak anion exchang wax column mobil phase elut system design maxim separ singl ionicelectrostat interact found although chaotrop help signific benefici effect hydrophil wax column high organ low salt mobil phase requir product elut separ also benefit ph gradient effect stationari phase electrostat potenti analyt ionize extraordinari degre separ achiev new wax method comparison sax strong anion exchang chromatographi first time extent deamin ps oligonucleotid direct determin chromatographi method approach repres result mechan separ discuss
|
D054735
|
T121
|
36,270,330
|
environment uranium exposur cytokin profil among mother newborn babi pair navajo irth cohort studi navajo nation heavili mine uranium u cold war lead legaci abandon u mine mill associ wast site navajo birth cohort studi initi assess effect non occup legaci exposur u pregnanc birth outcom child develop report babi detect urin u birth born mother urin u concentr greater nation norm pregnanc indic prenat exposur u assess immun alter associ u exposur mother babi investig associ cytokin profil matern u associ measur cytokin profil babi effect size differ cytokin profil evid among babi mother overal seven cytokin ifn il il il il gm csf tnf effect size babi higher nation u concentr medium larg or contrast three cytokin il il p tnf effect size almost reach medium strength or mother u nation norm effect prenat exposur uranium associ alter system immun respons result u exposur could impact matern health well healthi child develop induct inflamm autoimmun chronic diseas relat immun dysfunct may affect long term health
|
D014501
|
T196
|
36,270,329
|
exposur mixtur per polyfluoroalkyl substanc modul pulmonari express ace circul hormon cytokin genet environment factor impact interindividu variabl suscept communic non communic diseas class ubiquit chemic per polyfluoroalkyl substanc pfas link epidemiolog studi immunosuppress increas suscept viral infect possibl mechan well elucid begin gain insight role pfas suscept one viral infect sever acut respiratori syndrom coronavirus sar cov male femal cbl j mice expos control water mixtur pfas pfos pfoa pfna pfhxs genx week lung isol examin express sar cov relat receptor angiotensin convert enzym ace other secondari analys includ circul hormon cytokin shown direct indirect impact ace express sever viral infect chang mrna protein express analyz rt qpcr western blot circul hormon cytokin determin elisa meso quickplex pfas mixtur decreas ace mrna fold male mice p signific chang observ femal addit tmprss anpep enpep dpp gene implic covid infect modul due pfas plasma testosteron estrogen strike decreas due pfas correspond pfas mediat repress repres pulmonari ar target gene hemoglobin beta adult major chain hbb b ferrochelatas fech collagen type xiv alpha chain cola aminolevulin synthas ala final pfas modul circul pro anti inflammatori mediat includ ifn downregul fold femal p fold male p il upregul fold male p chang femal conclus data indic long term exposur pfas mixtur impact mechan relat express ace lung work provid mechanist rational import futur studi pfas exposur subsequ viral infect
|
D000086382;D005466
|
T047;T067;T109
|
36,270,328
|
tumorigenesi axon regul pancreat cancer mathemat approach nervous system today recogn play import role develop cancer inde neuron extend long process axon grow infiltr tumor order regul progress diseas posit negat way depend type neuron consid mathemat model biolog process allow formal nerv tumor interact test hypothes silico better understand phenomenon work introduc system differenti equat model progress pancreat ductal adenocarcinoma pdac coupl associ chang axon innerv studi asymptot behavior model confirm experiment observ pdac develop correl type densiti axon tissu studi identifi sensit model paramet identifi analysi inform adequaci paramet model experiment data sensit analysi contribut factor develop cancer lead signific insight main neural checkpoint mechan control progress pancreat cancer final give exampl simul effect partial complet denerv shed light complex correl healthi pre cancer cancer cell densiti axon opposit function
|
D010190;D021441
|
T191
|
36,270,327
|
turboid function effici biotin ligas bioid applic xenopus embryo bioid proxim label strategi whose goal identifi vivo protein protein interact central compon strategi modifi biotin ligas enzym promiscu add biotin group protein close proxim transfer biotin group provid power tag purif thus identif interact protein varieti modifi biotin ligas creat bioid origin enzym ineffici requir long incub time high intracellular biotin concentr protein label limit hinder applic bioid context develop embryo process cell divis cell fate decis occur rapid recent new biotin ligas call turboid develop address mani defici previous enzym paper compar turboid bioid biotin ligas develop xenopus embryo find turboid enzym sever advantag bioid enzym turboid label protein effici without addit addit biotin occur rang temperatur compat cultur xenopus embryo biotinyl event occur rapid limit turboid express activ thus turboid effici tool bioid applic xenopus embryo use facilit identif interact protein specif network complex xenopus develop
|
D001710;D008025
|
T121;T116;T127;T109;T126
|
36,270,326
|
letter specif crowd read evid erp compar process letter symbol stimuli present briefli right left visual field either isol surround two flank charact categori flanker could arrang horizont vertic particip perform two altern forc choic afc task isol charact central charact flank display target altern afc task charact categori target present display record eeg order investig time crowd effect isol vs flank condit hypothes differenti impact crowd letter symbol behavior result show signific differ isol letter symbol signific higher accuraci flank letter compar flank symbol effect stimulus type signific greater horizont align stimuli likewis amplitud n follow negat identifi n differ signific compar isol letter symbol differ flank stimuli flank letter show signific greater n n amplitud compar flank symbol n n amplitud also signific greater flank vs isol letter wherea symbol show signific differ opposit direct n conclud process compact string letter optim skill read via chang map visual featur onto letter ident multi letter array order reduc interf effect excess crowd
|
D011932;D010364
|
T056;T041
|
36,270,309
|
intraop electrocorticographi use high frequenc oscil spike tailor epilepsi surgeri netherland hfo trial randomis singl blind adapt non inferior trial intraop electrocorticographi use tailor epilepsi surgeri analys interict spike spike pattern delin epileptogen tissu high frequenc oscil hfos intraop electrocorticographi propos new biomark epileptogen tissu higher specif spike prospect test non inferior hfo guid tailor epilepsi surgeri spike guid tailor seizur freedom year
|
D004833;D004827;D004828
|
T033;T047
|
36,270,288
|
butterfli graft techniqu address intern nasal valv nasal airway obstruct common present complaint otolaryngolog clinic intern valv common implic anatom area obstruct nasal butterfli graft robust techniqu address subsit good report function aesthet outcom primari secondari rhinoplasti describ approach patient evalu surgic candid select oper techniqu outcom assess techniqu
|
D015508;D012225
|
T033;T047;T061
|
36,270,284
|
rag acceler lipofuscin accumul brain implic human stem cell brain transplant studi immunodefici mice wide use human stem cell transplant research recombin activ gene rag delet result immunodefici lead acceler age zebrafish increas cytosol accumul lipofuscin lf unlik zebrafish mammal two homolog rag rag regul adapt immun current littl known rag rag may impact age lf accumul immunodefici mous brain may confound result human neural cell transplant studi demonstr rag mous brain lf appear earli spread broad emit strong autofluoresc accumul age lf found various type glial cell includ xenograft human microglia surpris rag mous brain lf autofluoresc seen much older age compar rag brain studi provid direct evid rag expedit lf occurr set context studi use age immunodefici mice
|
D008062;D015027
|
T123;T013;T109
|
36,270,283
|
plastic ocular surfac epithelia use murin model limbal stem cell defici delin metaplasia transdifferenti maintain corneal health transpar necessari pre requisit exquisit vision function ascrib stem cell scs nestl within limbus perturb site deplet scs result limbal sc defici character murin model diseas discov unusu transform phenomena corneal surfac includ goblet cell metaplasia gcm conjunctiv transdifferenti squamous metaplasia sqm gcm aros k differenti conjunctiv epitheli cell limbus breach exacerb neovascular region within cornea harbor newli transform k epithelia void blood vessel gcs suggest cornea also initi self repair program knowledg intrins circuit contribut cell ident chang lineag restrict epithelia invalu design new therapeut patient blind corneal diseas
|
D016850;D019573;D003316
|
T023;T024;T047
|
36,270,282
|
generat function compet hepat stellat cell human stem cell model liver fibrosi vitro detail understand fibrogenesi hamper lack import function quiescenc characterist vitro model recapitul hepat stellat cell hsc activ studi establish robust endoderm mesoderm sourc quiescent like induc hscs ihsc deriv human pluripot stem cell notabl ihsc present featur matur hscs includ accumul vitamin lipid droplet maintain quiescent featur addit ihsc display fibrogen respons secret collagen respons hepatox caus thioacetamid acetaminophen hepat b c virus infect antivir therapi attenu viral induc ihsc activ interest endoderm mesoderm deriv ihsc show similar ihsc phenotyp therefor provid novel robust method effici generat function ihsc hesc ipsc differenti could use model hepatocyt toxic predict anti liver fibrosi drug screen viral hepat induc liver fibrosi
|
D055166;D039904
|
T025
|
36,270,281
|
deciph roadmap vivo reprogram toward pluripot differenti cell convert pluripot stem cell express transcript factor oct sox klf myc oskm process known reprogram use singl cell rna sequenc pancrea undergo reprogram identifi marker along trajectori acinar cell ident pluripot marker allow direct situ visual cell undergo dedifferenti acquir featur earli advanc intermedi reprogram also find fraction cell dedifferenti upon oskm express character stress marker reg ap famili import marker intermedi reprogram pancrea also observ stomach colon cultur fibroblast express oskm among lya protein characterist progenitor cell general upregul tissu repair roadmap defin intermedi reprogram state could function relev tissu regener rejuven
|
D039904;D057026
|
T025
|
36,270,280
|
human prime nave pscs abl differenti trophoblast stem cell recent deriv human trophoblast stem cell tscs placent cytotrophoblast blastocyst open opportun studi develop function human placenta recent report suggest human nave prime pluripot stem cell pscs retain exclus potenti generat tscs report absenc wnt stimul transform growth factor tgf pathway inhibit lead direct robust convers prime human pscs tscs result prime psc deriv tsc line exhibit self renew differenti main trophoblast lineag present rna epigenet profil indistinguish recent establish tsc line deriv human placenta blastocyst isogen human nave pscs expand human enhanc nave stem cell medium hensm condit activ nuclear yes associ protein yap signal suffici convers necessari human tsc mainten find underscor residu plastic prime human pscs allow vitro convers extra embryon trophoblast lineag
|
D014327;D039904
|
T018;T025
|
36,270,279
|
mountain lion avoid burn area increas riski behavior wildfir fragment urban landscap urban environ high risk area larg carnivor anthropogen disturb reduc fit increas mortal risk catastroph event like larg wildfir occur trade off acquir resourc avoid risk urban environ intensifi landscap context could lead increas risk take behavior carnivor burn area allow meet energet need potenti lead human wildlif conflict studi mountain lion behavior use gps locat acceleromet data individu track larg wildfir woolsey fire within high urban area los angel california usa wildfir mountain lion avoid burn area increas behavior associ anthropogen risk includ frequent road freeway cross mean cross increas per month greater activ daytim mean increas daytim activ time like encount human mountain lion also increas amount space use distanc travel mean distanc increas km per month intrasexu overlap potenti put risk intraspecif conflict joint pressur urban sever wildfir alongsid result risk take could thus increas mortal extinct risk popul alreadi suffer low genet divers necessit increas connect fire prone area
|
D046011;D000075923;D005390
|
T015;T070;T067
|
36,270,272
|
demand changeabl theranost hydrogel visual imag guid antibacteri photodynam therapi promot wound heal antibacteri wound dress confront challeng real time imag infect wound effect remov bacteri debri steril promot heal process herein inject theranost hydrogel construct antimicrobi peptid polylysin epl polydopamin pda nanoparticl real time diagnosi infect wound imag guid antibacteri photodynam therapi pdt demand remov bacteri debri ureido pyrimidinon conjug epl produc plu hydrogel quadrupl hydrogen bond inocul tetraki carboxyphenyl porphyrin tcpp load pda ptc nanoparticl introduc schiff base linkag plu ptc hydrogel doubl cross link network enhanc mechan perform adhes strength self heal properti hydrogel dynam cross link enabl phototherm remov inject plu precursor ptc nps generat situ sol gel transform acid trigger releas tcpp restor fluoresc emiss real time imag infect wound nm illumin releas tcpp infect wound illumin nm launch precis antibacteri pdt strengthen bacteri captur hydrogel hydrogel wrap bacteri debri remov illumin nm hydrogel dress chang acceler heal infect wound simultan relief oxid stress regul inflammatori factor acceler collagen deposit promot angiogenesi thus studi demonstr feasibl strategi wound infect theranost bacteri infect trigger visual imag effici nonantibiot steril demand dress chang bacteri debri remov
|
D010778;D014946
|
T061;T046
|
36,270,249
|
argininosuccin lyas drive activ mutant tert promot glioblastoma cancer specif tert promot mutat link reactiv epigenet silenc tert gene creat de novo bind motif e twenti six transcript factor especi gabpa mutat switch tert epigenet repress state express state defin reveal egfr activ induc erk depend phosphoryl argininosuccin lyas asl ser lead interact asl gabpa mutant region tert promot asl generat fumar inhibit kdmc lead enhanc trimethyl histon h lys hkme turn promot recruit c myc tert promot tert express express asl sa abrog bind gabpa result reduc tert express inhibit telomeras activ shorten telomer length impair brain tumor growth mice studi reveal unrecogn mechanist insight epigenet activ mutant tert promot gabpa interact asl play instrument role
|
D005909;D019098
|
T191;T126;T116
|
36,270,248
|
altern cleavag polyadenyl generat downstream uncap rna isoform translat potenti use altern promot splice cleavag polyadenyl apa generat mrna isoform expand divers complex transcriptom uncov thousand previous undescrib uncap polyadenyl transcript upt show transcript resist exonucleas due high structur rna n methyladenosin modif termini upt appear downstream apa site within host gene induc upon apa activ strong enrich polysom rna fraction indic upt translat potenti inde apa promot downstream translat initi non canon protein output consist chang peptid present cell surfac last demonstr biolog import upt use bcl promin anti apoptot gene whose entir code sequenc upt generat utr embed apa site thus apa account termin transcript also generat downstream uncap rnas translat potenti biolog impact
|
D026723;D059368
|
T123;T044;T114
|
36,270,247
|
field guid endogen retrovirus regulatori network germ cell subject exogen retrovirus infect occasion result genom integr retrovir gene sequenc endogen retrovirus erv found throughout mammalian genom initi thought inert appreci erv often co opt complex physiolog process howev unregul erv transposit express threat cellular fit genom integr mammalian cell must control erv pre post transcript mechan provid field guid molecular machineri identifi silenc erv
|
D020077;D012192
|
T005;T047
|
36,270,246
|
vitamin k new guardian ferroptosi dietari factor vitamin k found protect ferroptosi form cell death driven lipid peroxid reveal new dietari link cancer degen condit key factor involv warfarin poison
|
D000079403
|
T043
|
36,270,245
|
brca protect fragil deshpand et al demonstr brca tumor suppressor task protect genom encod gene intrins fragil
|
D019313;D016147
|
T123;T116;T028
|
36,270,244
|
right target chromatin jet aris target cohesin load wild type cell uncov inform featur genom structur guo et al describ chromatin jet quiescent murin thymocyt mb structur form target cohesin load narrow access chromatin region visibl promin diagon stripe contact map
|
D002843;D002868
|
T123;T116
|
36,270,243
|
condens place hide self immunostimulatori rna distinguish self non self immun system essenti avoid inflammatori autoimmun diseas maharana et al reveal mechan hide self immunostimulatori rna involv three variabl equat samhd exonucleas activ singl strand rna rna protein condens
|
D012313;D020559
|
T126;T116;T114
|
36,270,242
|
meet author yinglu li elizabeth goldberg xiao chen co first author yinglu li elizabeth goldberg xiao chen speak molecular cell scientif journey mother encourag factor go choos lab joy collabor aim big paper histon methyl antagon drive tumor immun evas squamous cell carcinoma
|
D006657
|
T123;T116
|
36,270,233
|
propeptid base biosensor select detect vibrio cholera use environ sensit fluorophor proteas attract target infecti diseas diagnost peptid base sensor cleav pathogen proteas provid rapid readout infect howev identifi peptid substrat specif target pathogen signific challeng demonstr structur propeptid domain bacteri proteas repurpos proteas activ biosensor cholera pathogen vibrio cholera found peptidas inhibitor domain secret v cholera proteas ivap rapid degrad v cholera intestin bacteria conjug domain environ sensit fluorophor develop fluoresc probe enabl speci specif detect v cholera mix bacteri cultur without nonspecif cleavag bacteria intestin cell find demonstr ivap propeptid suffici impart select cleavag base v cholera biosensor suggest domain could potenti har diagnost applic
|
D014734;D015374
|
T007;T059;T075
|
36,270,232
|
fish balanc toward promyelin drug discoveri issu hberlein et al demonstr role gpr regul zebrafish oligodendrocyt differenti zebrafish express human gpr respond modul inact endogen zebrafish receptor find highlight potenti human zebrafish vivo platform target remyelin drug screen
|
D009836;D015027
|
T025;T013
|
36,270,231
|
local matter target protein degrad mani factor influenc effici target protein degrad induc proteolysi target chimera protac issu cell chemic biolog simpson et al highlight impact subcellular local studi elucid protein interest exhibit differ amen protac mediat degrad differ cellular compart
|
D011506;D044767
|
T123;T126;T116
|
36,270,225
|
constrain arm slip perturb result higher fall frequenc young adult slip fall incid major health concern although studi report mechan benefit upper extrem respons slip regain balanc current known reactiv arm motion aid recoveri slip event sixti four healthi young adult random gait condit arm free arm constrain contralater arm slip foot constrain ipsilater arm slip foot constrain wear protect har particip travers walkway expos unexpect slip group arm constrain exhibit higher proport fall compar group arm free vs addit individu assign contralater arm constraint group exhibit signific higher proport fall compar group ipsilater arm constrain vs find suggest arm motion aid recoveri balanc slip perturb motion arm contralater slip foot appear import train upper extrem reactiv respons train arm may use adjunct fall prevent program fall prevent
|
D004856;D001132
|
T040;T029
|
36,270,222
|
interact penicillium brevicompactumpenicillium expansum acinetobact calcoaceticus isol drink water biofilm develop control bacteria filament fungi ff common encount biofilm develop drink water dw distribut system dwds despit intim ecolog relationship research tend studi bacteria ff separ work assess impact bacteria ff associ biofilm format toler chlorin one strain acinetobact calcoaceticus isol dw use model bacterium penicillium brevicompactum p expansum isol dw ff select singl speci inter kingdom adhes biofilm format occur two shear stress condit pa sessil structur character term biomass product respiratori activ structur result show pa shear stress calcoaceticus ff associ favour biofilm product inter kingdom biofilm produc biomass calcoaceticus singl speci reduc calcoaceticus suscept disinfect particular high sodium hypochlorit shc concentr addit p brevicompactum form singl speci biofilm high resist remov inactiv shc presenc p brevicompactum p expansum inter kingdom biofilm signific decreas shc remov inactiv effect comparison bacteri biofilm alon propos use bacteria form biofilm repres dwds provid inaccur conclus particular term biofilm product suscept disinfect
|
D060766;D016954
|
T007;T167
|
36,270,221
|
fungal communiti brazilian cassava tuber food product cassava manihot esculenta crantz one wide cultiv food world great socio econom import especi develop countri predomin consum boil form also use produc number product includ cassava starch sour starch cassava flour tapioca flour hydrat cassava starch fungal spoilag occur throughout product chain impair product qualiti well pose potenti risk contamin mycotoxin use multidisciplinari approach base phenotyp molecular data itsbenatef arpb loci investig mycobiota sampl includ root soil product collect state paulo brazil total fungal groupsgenera morpholog character differ speci molecular identifi predomin group cassava tuber fusarium spp penicillium spp trichoderma spp cassava product frequent group penicillium spp paecilomyc spp potenti toxigen speci also found includ paecilomyc saturatus penicillium citrinum p paneum p brevicompactum p chrysogenum fusarium foeten fusarium mundagurra soil cultiv cassava sampl group found frequent penicillium spp cladosporium spp fusarium spp speci found cassava tuber andor product sampl also present soil includ f mundagurra neocosmospora solani p citrinum p brevicompactum general higher occurr penicillium spp fusarium spp trichoderma spp predomin speci f fabacearum p citrinum mycobiota brazilian cassava prove extrem divers occurr sever speci cassava tuber andor product report herein first time potenti toxigen speci found cassava tuber cassava product soil show import constant monitor substrat
|
D002365;D000072761
|
T004;T002
|
36,270,220
|
cluster analysi clinic biochem electrophysiolog featur essenti tremor patient exploratori studi essenti tremor et one common movement disord clinic heterogen et studi mani year howev practic comprehens studi dedic assess biochem electrophysiolog paramet associ sever motor non motor disord present patient et take account heterogen
|
D020329
|
T047
|
36,270,219
|
earli neuroimag find infant diagnos inherit metabol disord neonat period case control studi imd diagnos neonat period sever neurolog find neuroimag play essenti role diagnosi aim investig earli cranial mri find newborn suspect imd determin imd relat neuroimag pattern earli infant period
|
D059906;D008659
|
T060;T047
|
36,270,184
|
effect two firefight chemic formul phos chek lcw blazetam stripe marsh frog limodynast peronii tadpol surviv growth develop behaviour global wildfir event project becom frequent sever due continu threat climat chang result increas demand effect fire mitig method firefight chemic ffcs includ retard foam water enhanc often use prevent spread wildfir howev impact ffcs wildlif ecosystem poor understood investig effect two common ffc formul phos chek lcw blazetam tadpol surviv growth develop swim behaviour tadpol stripe marsh frog limnodynast peronii expos two concentr either phos chek gl blazetam gl day highest concentr phos chek lethal tadpol mortal gradual increas time anim surviv day ffcs influenc growth develop tadpol though effect sever tadpol expos phos chek formul phos chek found complet stop tadpol growth develop day exposur wherea blazetam signific delay growth develop comparison control nevertheless treatment appar effect tadpol movement pattern swim activ greater toxic caus phos chek treatment like relat increas ammonia alter water qualiti paramet runoff accident applic common use ffcs small waterway may therefor import ramif aquat biota
|
D014874;D049851
|
T131;T204
|
36,270,182
|
explor physiolog role circular rnas livestock anim circular rnas circrna recent identifi class rnas produc via back splice coval linkag rna end result circular rna molecul physiolog circrna known influenc varieti biolog pathway also regul transcript post transcript rna splice interact protein microrna mirna function circrna known competit bind various rna molecul includ mirna compet endogen rna long noncod rna therebi signific influenc gene express sinc gene express crucial factor under econom import livestock trait like circrna signific influenc livestock trait like growth milk product reproduct meat qualiti hair follicl growth gametogenesi thousand circrna recogn differ speci anim circrna also shown regul stress respons may crucial anim welfar therefor review aim highlight biogenesi circrna along potenti implic livestock present summari would offer fundament understand molecular machineri under circrna associ biolog phenomena emphas need explor role circrna product reproduct physiolog attribut anim
|
D035683;D062085
|
T123;T114
|
36,270,181
|
baicalin inhibit oxid injur mous uterin tissu induc acut heat stress activ keapnrf signal pathway heat stress effect physiolog function bodi reproduct system one sensit imper find suitabl measur allevi harm effect heat stress baicalin well known antioxid properti examin whether baicalin could reduc oxid injur uterin tissu heat stress mice mice divid four group control con baicalin bai heat stress h heat stress plus baicalin h bai oxid damag uterin tissu detect elisa h e stain tunnel assay immunohistochem stain proteinmrna express keapnrf relat factor detect western blot qpcr result show mice heat stress c h induc macroscop chang signific increas mda content reduc activ antioxid enzym includ sod cat gsh px uterin tissu compar con group heat stress regul caspas caspas enhanc apoptosi endometri epitheli glandular epitheli cell improv ho mrnaprotein nqo protein express regul mrnaprotein keap compar h group antioxid enzym activ nrf protein nrf nqo gclc mrna express signific increas h bai group uterin epitheli cell apoptosi mda content caspas caspas keap protein ho mrna express decreas h bai group mice compar h group briefli acut heat stress caus oxid injur apoptosi mous uterin tissu baicalin protect uterin tissu damag possibl keapnrf signal pathway
|
D018882;D012376
|
T047;T037
|
36,270,170
|
human dihydrofol reductas inhibit effect phenylpyrazolo pyrimidin synthesi antitumor evalu molecular model studi new seri pyrazolo pyrimidin analogu bear differ amino acid conjug synthes aim evalu antitumor effect simultan inhibit human dihydrofol reductas hdhfr novel compound test screen enzym inhibit activ hdhfr besid vitro cytotox six human mtx resist cancer cell line name human prostat cancer pc pancreat human cancer cell line bxpc colorect carcinoma hct human hepatocellular carcinoma hepg cervic carcinoma hela mammari gland breast cancer mcf besid normal immort pancreat cell line hpde compound e f g inhibit dhfr consider low ic comparison mtx ic besid characterist cytotox effect differ resist cancer cell line flow cytometri done activ candid compound e mcf breast cancer cell line result illustr compound e induc apoptosi arrest mcf cell cycl gs phase western blot visual quantif use confirm capabl compound e induc express proapoptot caspas bax protein mcf breast cancer cell line besid abil reduc express antiapoptot bcl protein molecular model studi demonstr compound e elucid bind energi kcalmol exceed normal ligand mtx kcalmol addit sever favor bind interact activ site residu
|
D000970;D001943
|
T121;T191;T109
|
36,270,169
|
structur base screen biolog valid anti thrombot drug dicoumarol novel potent ppar modul ligand ppar full agonist thiazolidinedion tzds known class effect drug treatment type diabet mellitus tdm howev recent therapeut benefit compromis sever undesir side effect studi host base repurpos strategi combin comprehens biolog evalu synergist employ seek potent ppar ligand led identif anti thrombot drug dicoumarol dic novel safer select ppar modul spparm advantag current tzd drug result vitro show dic potent bind affin weak agonist activ ppar downstream key gene moreov diabet model signific reduc blood glucos without lead weight gain bodi main organ tissu mechanist investig reveal dic possess desir pharmacolog properti main effect inhibit phosphoryl ppar ser select regul express insulin sensit resist gene final dock studi analysi potent bind mode dic ppar reveal remark differ interact region compar develop ppar agonist gave proof concept abovement mechan also provid molecular basi discrimin dic ppar ligand especi tzd drug taken togeth find suggest dic could serv new promis candid good therapeut index treat tdm especi tdm patient thrombosi
|
D003924;D045162;D013927
|
T121;T047;T046;T109
|
36,270,168
|
water solubl dual lysosomemitochondria target fluoresc probe detect water food herb live cell paper present new donor bridg acceptor type fluoresc probe mib bear two organell target group name posit charg benzothiazol group mitochondria morpholin moieti lysosom aqueous solut nucleophil addit hso donor mib block long rang conjug ict process result signific optic signal chang blue shift uv absorb fluoresc enabl colorimetr ratiometr fluoresc detect hso high select sensit detect limit nm mib offer obvious advantag good water solubl fast respons time within min uniqu dual lysosomemitochondria target capabl appli sens endogen exogen live cell fluoresc imag addit propos probe util determin bisulfit real water food herbal medicin sampl show good recoveri precis
|
D005456;D014867
|
T121;T197;T130
|
36,270,159
|
collagen fabric deliveri system wound heal new roadmap collagen biopolym found anim bodi one abund protein extracellular matrix provid strength skin joint bone human bodi import sourc elast strength extracellular matrix contribut structur physiolog integr tissu collagen play import role regul wound heal process help wound heal attract fibroblast encourag new collagen format wound bed therefor use supplementari aid wound treatment acceler heal process promin benefit incorpor collagen wound dress abil enhanc heal process critic wound collagen various collagen contain system prepar boost efficaci wound heal differ strategi like nanoscal reduct biopolym incorpor anti inflammatori antimicrobi drug collagen report review articl emphas use collagen wound heal various collagen fabric deliveri system nanofibr nanoparticl hydrogel film spong aid heal wound
|
D014945;D003094
|
T121;T123;T116;T040;T122
|
36,270,158
|
coupl benefit nanotopographi titania surfac chemistri foster endotheli reduc stent restenosi coronari stent recent advanc coronari stent distinct focus toward direct endotheli minim stent restenosi potenti via alter surfac topograph cue augment efficaci vascular implant perspect proven group util simpl easili scalabl nanosurfac modif strategi metal stent devoid drug polym present work explor impact surfac characterist modul cell respons vitro vivo use titania coat cobalt chromium cc stent without nanotopographi comparison commerci control interest titania nanotopographi facilit preferenti cell respons vitro titania coat bare cc surfac attribut surfac topographi hydrophil rough turn alter cellular adhes prolifer focal contact format endotheli smooth muscl cell also demonstr titania nanotextur play pivot role foster rapid endotheli minim neointim hyperplasia lead excel vivo patenc cc stent post week implant rabbit iliac arteri comparison bare cc nano less titania coat cc commerci drug elut stent cc des without administ antiplatelet agent excit result drug polym free titania nanotextur stent absenc platelet therapi reveal possibl propos altern clinic des coronari stent
|
D023903;D054855
|
T047;T074
|
36,270,150
|
biolog action prostanoid adipos tissu physiolog pathophysiolog condit adipos tissu establish endocrin organ play import role maintain metabol homeostasi adipos tissu releas sever bioactiv molecul call adipokin inflamm dysregul adipokin synthesi secret observ obes relat diseas caus adipos tissu dysfunct prostanoid belong eicosanoid famili lipid mediat synthes adipos tissu play critic role adipos tissu biolog review summar current knowledg regard interact prostanoid adipokin express prostanoid receptor prostanoid synthas enzym adipos tissu health diseas furthermor involv prostanoid physiolog function dysfunct adipos tissu includ inflamm lipolysi adipogenesi thermogenesi brown adipocyt vascular tone regul also discuss examin studi use pharmacolog approach genet modifi anim prostanoid receptorssynthas enzym overal present review provid perspect evid literatur regard biolog effect prostanoid adipos tissu among prostanoid prostaglandin e pge promin regard substanti role adipos tissu physiolog pathophysiolog target prostanoid may serv potenti therapeut strategi prevent treat obes relat diseas
|
D011453;D000273
|
T121;T024;T109;T201;T125
|
36,270,149
|
diagnos local acut vestibular syndrom beyond hint exam assess acut dizzi patient hint plus head impuls nystagmus test skew plus bedsid assess auditori function exam crucial compon bedsid exam howev addit ocular motor find help clinician distinguish peripher central etiolog enabl accur local especi patient acut dizzi vertigo andor imbal without spontan nystagmus review literatur find beyond hint includ saccadesocular lateropuls smooth pursuit provoc maneuv includ head shake posit test part hint exam addit expound local valu nystagmus ocular align ocular tilt reaction part hint exam paper organ neuroanatom base brainstem cerebellar structur report caus acut vestibular syndrom
|
D009759;D015835
|
T033;T184;T047
|
36,270,148
|
risk control assess sulfid rich sediment remedi control releas calcium nitrat nitrat stimul wide use sediment remedi elimin sulfid degrad organ pollut immobil phosphorus howev environment risk nitrat escap subsequ releas pollut eg nitrit ammonium trace metal water bodi applic receiv less attent studi control releas nitrat pellet sedcan pellet manufactur appli differ sediment depth examin effect control risk nitrat escap subsequ pollut releas germin submerg plant also analyz assess ecolog risk associ remedi sediment result show sedcan pellet slowli releas calcium nitrat led denitrifi sulfid oxid organ matter degrad immobil phosphorus calcium bound speci gas product denitrif increas sediment poros led concomit releas nitrit ammonium heavi metal creat secondari risk applic sedcan pellet depth decreas nitrat escap secondari risk presum mean cap effect upper sediment releas nitrat ammonium ni cu partial limit sedcan pellet incorpor deeper sediment cm moreov rang sulfid oxid extend upper lower sediment profil column sulfid oxid effici reach final increas germin bacopa monnieri demonstr comparison refer materi ecolog risk treat sediment reduc habitat function sediment restor nitrat stimul remedi result studi provid valuabl guidelin nitrat stimul remedi sulfid rich black odor sediment
|
D064751;D004785;D014874
|
T104;T197;T131
|
36,270,147
|
biofilm stratif counter diffus membran biofilm bioreactor mbfrs aerob methan oxid coupl aerobicanox denitrif effect oxygen pressur aerob methan oxid coupl denitrif ame execut membran biofilm bioreactor mbfrs provid high promis simultan mitig methan ch emiss remov nitrat wastewat howev systemat experiment investig oxygen partial pressur affect develop characterist counter diffusion biofilm well spatial stratif profil cooper interact biofilm microb still absent studi combin optic coher tomographi oct confoc laser scan microscopi clsm situ character develop counter diffus biofilm mbfr first time reveal oxygen partial pressur onto mbfr capabl manipul biofilm thick spatial stratif manag distribut function microb optim oxygen partial pressur psig oxygen content manipul counter diffusion biofilm ame process obtain highest denitrif effici due main biofilm proper dynam balanc aerob layer anox layer suitabl gradient suffici aerob methanotroph achiev aerob layer favor methan oxid complet deplet access organ sourc kept avoid constrain denitrif activ anox layer use metagenom analysi fluoresc situ hybrid fish stain spatial distribut function microb within counter diffus biofilm success evidenc rhodocyclacea one typic aerob denitrifi found surviv gradual enrich aerob layer play key role denitrif aerob situ biofilm visual character evidenc direct first time cooper path denitrif ame counter diffus biofilm involv aerob methanotroph heterotroph aerob denitrifi heterotroph anox denitrifi
|
D008697;D058440
|
T067;T109
|
36,270,146
|
vanad reduc bacteria archaea may use differ mechan reduc vanad vanadium contamin riverin ecosystem reveal combin dna sip metagenom bin vanadium v transit metal pose health risk expos human microorgan play import role remedi v contamin reduc toxic mobil vanad v v less toxic mobil v iv studi dna stabl isotop probe sip coupl metagenom bin use identifi microorgan respons v v reduct determin potenti metabol mechan cultur inocul v contamin river sediment anaeromyxobact geobact spp identifi putat v v reduc bacteria methanosarcina spp identifi putat v v reduc archaea bacteria may use two nitrat reductas narg napa respiratori v v reduct demonstr previous speci propos methanosarcina spp may reduc v v via anaerob methan oxid pathway aom v rather via respiratori v v reduct perform bacteri counterpart indic presenc gene associ anaerob methan oxid coupl metal reduct metagenom assembl genom mag methanosarcina briefli methan may oxid revers methanogenesi pathway produc electron may captur v v promot v v reduct special v v reduct member methanosarcina may driven electron transport com scob heterodisulfid reductas hdrde f h dehydrogenas fpo multi heme c type cytochrom mhc identif putat v v reduc bacteria archaea predict differ pathway v v reduct expand current knowledg regard potenti fate v v contamin site
|
D001105;D054892
|
T194;T028
|
36,270,145
|
comparison uvo uvo ps process marin oili wastewat treatment degrad perform toxic evalu floc analysi effici site treatment technolog crucial mitig marin oili wastewat pollut work investig ozon ultraviolet uv uvo persulf ps process treatment marin oili wastewat includ degrad perform acut toxic evalu oil floc analysi benchtop circul flow photoozon reactor degrad perform studi measur degrad rate total oil concentr specif oil compon n alkan polycycl aromat hydrocarbon pah total organ carbon toc result show uvo ps could signific enhanc remov effici two process remov effici min acut toxic analysi show wastewat qualiti signific improv four fold ec vibrio fischeri mortal artemia franciscana decreas h exposur morpholog function group floc character show float floc could degrad especi uvo ps process studi rais discuss regard futur site applic base system base result generat treatment effici toxic floc character regul oxid strength optim reaction system could practic strategi site marin oili wastewat treatment
|
D014874;D018508;D010126
|
T131;T052;T103;T057
|
36,270,144
|
spatiotempor distribut fate neonicotinoid insecticid urban water cycl lower reach yangtz river china neonicotinoid insecticid nnis popular insecticid worldwid yet spatiotempor distribut fate urban water cycl remain limit larg watersh scale thus investig ten kind nnis surfac water lower reach yangtz river hub urban water cycl season brief eight ten nnis detect thiamethoxam thm imidacloprid imi dinotefuran dnt abund nnis surfac water concentr ngl ngl ngl respect averag concentr total nnis summer fold higher season nnis effluent municip wastewat treatment plant wwtps lower surfac water averag concentr total nnis effluent industri wwtps fold higher surfac water indic insecticid product import sourc nnis surfac water dnt recalcitr nni wwtps averag remov effici drink water treatment plant dwtps remov effici nnis limit except clothianidin clo risk assess show nnis pose medium high risk aquat life dnt contribut cumul risk detect nnis studi investig spatiotempor distribut risk nnis provid inform supervis nnis yangtz river basin china
|
D007306;D014874
|
T131
|
36,270,143
|
interfaci reaction catalyt ozon membran result releas degrad irrevers foulant effici situ self clean catalyt ceram membran tailor mno co nanoparticl mn co cm fabric densiti function theori calcul result substanti molecular ozon could effect adsorb oxygen vacanc ov mn co cm surfac direct activ surfac bound atom oxygen ad peroxid ad ultim produc oh mn co cm coupl ozon effici remov foulant permeat membran surfac simultan lead situ format oh chang natur irrevers foulant ultim result rapid releas degrad humic acid like substanc caus irrevers foul howev commerci cm ozon main remov cake layer foul includ protein like fulvic acid like substanc follow slow releas degrad irrevers foulant result mani humic acid like substanc remain membran surfac irrevers foul base flux growth rate mn co cm time higher cm ozon studi provid new insight mechan situ membran foul mitig use effici catalyt ceram membran facilit develop membran antifoul strategi
|
D010126;D018508
|
T052;T103;T057
|
36,270,142
|
molecular screen character legionella pneumophila associ free live amoeba domest hospit water system free live amoeba ubiquit environ caus opportunist non opportunist infect human genera amoeba natur reservoir opportunist plumb pathogen legionella pneumophila studi presenc free live amoeba legionella investig water biofilm sampl collect australian domest n hospit water system n sampl screen parallel use molecular cultur base method direct quantit polymeras chain reaction qpcr assay show sampl posit legionella l pneumophila acanthamoeba vermamoeba vermiformi gene marker sampl contain cultur l pneumophila serogroup sg l pneumophila sg non pneumophila legionella total sampl posit free live amoeba use method standard cultur found sampl posit amoeba either acanthamoeba allovahlkampfia stenamoeba v vermiformi v vermiformi show highest overal frequenc occurr acanthamoeba v vermiformi isol demonstr high thermotoler osmotoler strong broad spectrum bacteriogen activ gram negat gram posit bacteria import legionella posit sampl also posit amoeba co occurr statist signific p accord qpcr fluoresc situ hybrid v vermiformi allovahlkampfia harbour intracellular l pneumophila knowledg first time allovahlkampfia stenamoeba demonstr host l pneumophila potabl water result demonstr import amoeba engin water system pathogen reservoir legionella high frequenc gymnamoeba detect studi australian engin water system identifi issu signific public health concern futur water manag protocol incorpor treatment strategi control amoeba reduc risk end user
|
D000656;D016952;D007875;D060766;D000048
|
T167;T007;T204
|
36,270,141
|
interpret impact extravers neurotic social media addict among univers student pakistan mediat moder model studi aim investig associ two import person trait extravers neurotic social media addict sma social media usag smu consid import moder role life satisfact collect data univers student pakistan electron survey smartpl softwar util perform partial least squar structur equat model pls sem analys verifi propos model result reveal signific direct associ extravers social media addict wherea social media usag partial mediat relationship howev direct relationship neurotic social media addict found signific fulli mediat social media usag addit life satisfact reveal moder effect relationship extravers neurotic social media addict result contribut prior studi intens use social media whatev purpos lead social media addict life satisfact play role social media addict limit direct futur research discuss
|
D005120;D061108
|
T170;T041
|
36,270,109
|
age number relationship among age non chronolog age factor self perceiv drive abil autonom vehicl accept global adult age older rapid grow popul age associ declin perceptu cognit physic abil often creat challeng complet daili activ drive autonom vehicl av promis provid older adult one way maintain mobil independ howev recent survey av accept suggest older adult lower av accept compar younger generat one challeng assess account various non chronolog age factor contribut older adult perceiv drive skill util av fill research gap studi investig effect non chronolog age factor rate self perceiv drive abil av accept across three age group onlin survey conduct use amazon mechan turk mturk valid respons receiv respond categor younger year middl age year older year adult age group result show driver younger age higher educ attain rate higher social support lower rate self perceiv drive abil report will accept av find work help inform model av technolog accept guid develop market strategi promot knowledg av
|
D000063;D001334
|
T056;T037;T067
|
36,270,108
|
driver nt need learn ada limit comparison limit focus respons focus train approach expect driver learn rememb numer limit may practic approach train advanc driver assist system ada particular self initi train absenc formal train requir one altern focus import driver remain engag drive task respons focus approach investig effect two train video respons focus limit focus relianc intent trust ada knowledg remot studi particip n watch dashcam clip requir takeov takeov clip report whether would manual interven trust ada assess situat relianc intent trust respect particip also complet questionnair includ item measur ada knowledg respons collect three stage pre train post train follow session minimum four week later signific differ approach term knowledg situat ada would work appropri situat relianc intent trust takeov scenario compar respons focus video limit focus video associ lower trust takeov scenario negat bias post train ie bias toward report ada would work knowledg questionnair bias toward take manual controlnot use ada dashcam clip given limit differ train approach potenti drawback limit focus approach result suggest respons focus train approach worth explor
|
D000063;D001334
|
T056;T037;T067
|
36,270,098
|
separ identif complex flurbiprofen polyethylen glycol mono diester mixtur via hyphen hplc dad hrmsspe nmr system report use hyphen hplc dad diod array detector hrmsspe nmr system separ isol complex mixtur ester contain substanc similar lc retent time literatur known mono diester drug flurbiprofen polyethylen glycol form larg number substanc vari chain length chosen studi demonstr use hyphen system quick effect isol sixteen high similar individu ester autom fashion demonstr applic standard pharmaceut analysi qualiti control drug synthet solut ester extract flurbiprofen lozeng use purpos sole use system individu compound isol uv hrms nmr data could collect enabl identif differenti individu ester
|
D005480
|
T121;T109
|
36,270,097
|
metabonom rrna gene sequenc studi therapeut mechan danggui sini decoct collagen induc rheumatoid arthriti rat cold bi syndrom rheumatoid arthriti ra autoimmun diseas character persist joint inflamm develop rheumatoid arthriti direct correl disturb gut microbiom metabolit ra effect treat danggui sini decoct dsd tradit chines medicin tcm prescript treatis febril diseas research need clarifi precis mechan dsd treatment ra studi h nmr metabonom rrna gene sequenc techniqu use clarifi intervent dsd cia induc ra result h nmr metabolom fece reveal five metabolit alanin glucos taurin betain xylos disturb could regard potenti biomark ra intestin microbiom ra rat chang accord result rrna gene sequenc eight microb gnorankfeubacteriumcoprostanoligenesgroup gruminococcustorquesgroup gdubosiel glactobacillus gnorankfdesulfovibrionacea gbacteroid goscillibact gromboutsia occur signific genus level dsd signific impact six gdubosiel glactobacillus gnorankfeubacteriumcoprostanoligenesgroup gruminococcustorquesgrou gbacteroid gromboutsia three gnorankfeubacterium coprostanoligenesgroup gromboutsia glactobacillus regard key microbiom dsd treat ra three common metabol pathway taurin hypotaurin metabol alanin aspart glutam metabol primari bile acid biosynthesi discov base h nmr metabonom picrust predict rrna gene sequenc six scfas fece acet acid butyr acid propion acid caproic acid isobutyr acid valer acid increas signific ra accord outcom target scfas five scfas acet acid butyr acid propion acid caproic acid valer acid decreas signific due dsd treatment conclus studi indic dsd could regul ra metabol disord affect intestin microbiom metabolit also establish framework futur research exploit gut microb therapeut treat ra
|
D004365;D001169;D001172
|
T123;T047;T121;T050
|
36,270,086
|
comparison lumbar spine load kinemat healthi non specif low back pain individu unstabl lift activ evalu spinal load patient low back pain lbp essenti prevent lumbar disord mani studi investig relationship lift task variabl lumbar spine load manual lift activ natur extern load stabl versus unstabl load import variabl receiv less attent therefor present studi aim measur trunk kinemat estim compress shear load lumbar spine lift n stabl load n sensual unstabl load healthi non specif lbp individu lift activ maxim lumbar load estim use quasi static electromyographi emg driven musculoskelet model spine degre freedom rotat degre freedom lumbar joint seven rigid bodi pelvi thorac five vertebra muscl fascicl moreov maximum veloc acceler thorax lumbar pelvi well time lift activ analyz investig trunk kinemat result indic unstabl compar stabl lift activ caus signific larger peak l n versus n p l l n versus n p compress load lbp individu larger co contract trunk muscl found respons larger compress load lbp patient unstabl load lift hand load type stabl versus unstabl group lbp versus healthi effect kinemat variabl onset peak kinemat paramet signific later lbp patient slower movement chang movement strategi observ lbp group conclud natur extern load advers affect spinal load lbp patient therebi increas likelihood injuri pain
|
D008159;D017116
|
T184;T023;T047
|
36,270,075
|
eeg paramet endpoint epilepsi clinic trial expert panel opinion paper lack ideal measur treatment efficaci well acknowledg problem epilepsi communiti clinic care clinic trial whilst still current gold standard self report seizur frequenc signific underestim true number seizur account least equal import outcom paramet neurodevelop cognit rise diseas modifi treatment need reliabl endpoint practic clinic trial becom press paper assembl expert panel discuss natur need current limit obstacl base survey amongst expert queri import issu regard use electroencephalographi eeg paramet endpoint clinic drug devic develop
|
D000927;D004827
|
T033;T121;T047
|
36,270,058
|
demand target nanotheranost stimuli respons releas properti improv deliveri effici cancer nanocarri great potenti enhanc drug deliveri effici therapeut effect various cancer howev prematur drug leakag non specif target still limit deliveri effici present smart demand target nanotheranost system po pb spio stimuli respons releas properti improv deliveri effici ovarian cancer deliveri system prevent prematur drug leakag via boron ester linkag shield target moieti phenylboron acid non specif bind circul blood po pb spio would releas tumor target payload pb respons tumor microenviron pb abl target overexpress sialic acid tumor cell signific improv deliveri effici demonstr vivo signific enhanc signal near infrar fluoresc nirf magnet reson mr imag fold higher remark photo thermal therapeut effect complet cure rate ccr furthermor due demand target stimuli respons releas strategi nanotheranost system show greater deliveri effici even activ target small molecul control nanoformul believ delic design great potenti develop novel drug nanoformul
|
D010051;D053758
|
T191;T073
|
36,270,039
|
integr theori sampl nuclear forens investig present studi case theori sampl tos use make defens infer nuclear forens investig forens investig focus five suspici radioact materi seiz error introduc sampl sub sampl radioact materi evalu accord tos maximum sampl error toler use tos enabl forens team make infer seiz materi therefor make confid base statement exceed limit establish swiss radiolog protect ordin radioact substanc analysi isotop activ ratio allow team exclud potenti sourc radioact contamin howev possibl determin origin precis
|
D011835
|
T061
|
36,270,037
|
dietari intak antioxid vitamin associ reduc advers effect air pollut diabet find larg cohort studi remain unknown whether higher dietari intak antioxid vitamin could reduc harm effect air pollut incid diabet mellitus
|
D000393;D000397;D003920
|
T131;T047;T069;T080
|
36,270,036
|
fluorenyliden dianilin bafl antiestrogen advers effect femal develop cd mice mani phenol compound found endocrin disrupt activ arylamin analog phenol hydroxyl group substitut anilin amino group rare report fluorenyliden dianilin bafl arylamin analog fluoren bisphenol bhpf bhpf report strong antiestrogen could caus endometri atrophi ovarian damag advers pregnanc outcom anim bafl wide use materi synthet polym polyimid polyamid polyamin various use sinc assess antiestrogen bafl use varieti method look impact develop femal cd mice aid yeast estrogen screen assay found bafl possess obvious antiestrogen activ ic close tamoxifen bhpf use mous uterotroph assay found bafl obvious decreas uterin weight dose depend way histolog analys mous uteri reveal bafl induc mark endometri atrophi inhibit uterin develop immunohistochem analys show sprrd estrogen respons gene encod protein main express endometri epitheli cell bafl decreas area level sprrd stain mous uteri clear uterin transcriptom investig bafl signific downregul express multipl gene respond estrogen molecular dock show bafl could effect occupi antagonist bind pocket one amino group bafl form hydrogen bond side chain arg glu receptor result indic bafl exhibit clear antiestrogen characterist could interfer normal femal develop mice avoid use commod come direct contact human moreov studi indic arylamin analog phenol endocrin disrupt chemic might also endocrin disrupt activ
|
D004965;D004967
|
T125;T121;T033;T109
|
36,270,035
|
analysi role notch signal pathway modul deoxynivalenol cytotox deoxynivalenol trichothecen produc fungi widespread pose threat human anim health notch signal pathway tight involv cell fate determin aim studi investig role notch signal pathway exposur herein found notch signal pathway signific activ exposur notch express negat regul induc ros notch signal pathway block secretas inhibitor dapt exposur flow cytometri analysi antioxid paramet measur reveal dapt treatment signific aggrav oxid stress induc detect apoptosi show dapt treatment increas cell apoptot rate analysi reveal inhibit notch signal pathway reduc autophagi upon exposur rt qpcr western blot analysi show inhibit notch signal pathway aggrav cellular inflamm activ mapk pathway indic mapk pathway may downstream signal pathway taken togeth research reveal notch signal pathway essenti protect inhibit notch signal increas oxid stress caus cell apoptosi reduc autophagi aggrav cell inflamm exposur studi investig role notch signal pathway exposur provid basi explor mechan
|
D010975;D014255
|
T121;T123;T131;T109
|
36,270,034
|
widespread bacteri respons mechan bacteri metallogen detoxif high concentr heavi metal microbi miner increas use bioremedi heavi metal pollut better mechanist understand process involv regul requir improv practic applic microorgan bioremedi use combin morpholog tem analyt xrd xps ftir method togeth novel proteom analys investig detoxif mechan use rang bacteria includ strain bacillus velezensi lb escherichia coli dh b subtili pseudomona putida kt b licheniformi mt expos elev concentr cd combin cd pb cu zn presenc absenc ad cacl common featur detoxif includ biominer includ product biolog vaterit regul protein involv flagellar movement chemotaxi biofilm synthesi transmembran transport small molecul organ matter decomposit putat role differenti express protein detoxif discuss relat chemic morpholog data togeth provid import tool improv screen select practic applic bacteri isol bioremedi pollut environ
|
D019216;D016958
|
T196;T007
|
36,270,033
|
improv condens phase water dynam explicit nuclear quantum effect polariz q amoeba forc field introduc new parametr amoeba polariz forc field water denot q amoeba use simul explicit account nuclear quantum effect nqes studi made possibl thank recent introduc adapt quantum thermal bath adqtb simul techniqu comput cost compar classic molecular dynam flexibl q amoeba model conserv initi amoeba function form intermolecular potenti includ atom multipol descript electrostat interact quadrupol polar contribut base thole interact model buffer potenti model van der waal interact obtain use forcebal fit strategi includ high level quantum chemistri refer energi select condens phase properti target final q amoeba model shown accur reproduc gas phase condens phase properti notabl improv origin amoeba water model develop allow fine studi nqes water liquid phase properti averag h h angl compar gas phase equilibrium valu isotop effect q amoeba also provid improv infrar spectroscopi predict capabl compar amoeba overal show impact nqes depend under model function form associ strength hydrogen bond sinc adqtb simul perform near classic comput cost use tinker hp packag q amoeba extend organ molecul protein nucleic acid open possibl larg scale studi import nqes biophys
|
D014867;D000656
|
T121;T197;T204
|
36,270,030
|
fulli autom generat prebiot relev reaction network optim nanoreactor simul nanoreactor approach first introduc group martnez wang et al nat chem recent attract much attent abil acceler discoveri reaction pathway provid comprehens studi various simul paramet present altern implement reactiv enhanc spheric constraint function well detect reaction event context fulli autom postsimul evalu procedur base rdkit networkx analysi introduc chemic physic robust procedur examin investig reactiv select homogen system optim procedur appli gfn xtb level theori system compos hcn molecul argon atom act buffer yield prebiot plausibl primari secondari precursor synthesi rna furthermor formos reaction network explor lead numer sugar precursor discov compound reflect experiment find howev new synthet rout larg collect exot high reactiv molecul observ highlight predict power nanoreactor approach unravel reactiv manifold
|
D036103
|
T090
|
36,270,029
|
report surgic remov lymph node breast tumor recommend intern collabor cancer report intern collabor cancer report iccr support major patholog cancer organ aim standard evid base patholog report differ type cancer inclus paramet deem relev best patient care futur data collect lymph node metastasi one import prognost factor breast cancer
|
D010338;D001943
|
T191;T091
|
36,270,026
|
design synthesi biolog evalu novel pyrazol yl benzamid deriv contain oxazol group potenti succin dehydrogenas inhibitor seri pyrazol yl benzamid deriv contain oxazol group design synthes potenti sdh inhibitor accord result bioassay target compound display moder excel vitro antifung activ valsa mali sclerotinia scleotiorum alternaria alternata botryti cinerea among compound c c c exhibit excel inhibitori activ sclerotiorum boscalid ec mgl ec valu mgl respect vivo experi rape leav cucumb leav show compound c c exhibit consider protect effect sclerotiorum boscalid sem analysi indic compound c c signific destroy typic structur morpholog scleotiorum hypha respiratori inhibit effect assay compound c c exhibit strong inhibitori effect respir rate sclerotiorum mycelia close boscalid result molecular dock indic compound c c could form strong interact key residu trp arg p tyr q met p sdh furthermor antifung mechan deriv demonstr sdh enzymat inhibit assay result demonstr compound c c develop novel sdh inhibitor crop protect
|
D013385;D012232
|
T004;T126;T116
|
36,270,010
|
de novo construct chiral aminoindolin cu catalyz asymmetr cyclize subsequ discoveri unexpect sulfonyl migrat search effici strategi access structur novel aminoindolin great signific drug discoveri howev catalyt asymmetr de novo construct aminoindolin scaffold function prime diversif still remain elus report cu catalyz asymmetr cyclize ethynyl benzoxazinon amin produc chiral aminoindolin good yield high enantioselect yield er moreov radic mediat sulfonyl migrat product unexpect found afford new chiral aminoindolin bear alkenyl sulfonyl group retain enantiopur yield er bioactiv evalu indic aminoindolin show notabl antitumor activ chiral proven signific impact antitumor activ
|
D000588
|
T109
|
36,270,005
|
identif organ anion transport inhibitor screen structur base analysi clinic drug interact risk assess organ anion transport oat slca play import role hepat uptak renal secret sever endogen compound drug goal work understand structur activ oat inhibit assess clinic drug interact risk singl point inhibit assay use oat transfect hek cell employ screen compound concentr depend inhibit potenc ic measur identifi inhibitor acid repres inhibitor frequenc base plus zwitterion approxim doubl non inhibitor interest potent inhibitor low ic acid p k addit inhibitor signific larger lipophil non inhibitor silico binari model develop identifi inhibitor non inhibitor final vivo risk assess via static drug drug interact model identifi sever inhibitor potenti renal hepat oat inhibit clinic dose first studi assess global pattern oat ligand interact
|
D029362;D008099
|
T123;T023;T116
|
36,270,003
|
seed matur propag amyloid peptid aggreg alzheim diseas alzheim diseas neuropatholog character deposit amyloid peptid amyloid plaqu plaqu patholog start neocortex propag brain region moreov aggreg undergo matur indic occurr post translat modif show propag plaqu led presum non modifi follow aggreg matur sequenc seen neuropatholog human brain amyloid precursor protein transgen mice receiv intracerebr inject human brain homogen case vari phase load matur stage speed propag seed mice best relat phase donor progress speed matur stage aggreg matur thus differ form trigger propagationmatur aggreg may explain lack success therapeut target specif form
|
D016229;D000544
|
T047;T116;T048
|
36,270,002
|
doubl administr self complementari aavnduf prevent leigh diseas nduf mice leigh diseas subacut necrot encephalomyelopathi genet heterogen condit consist character defect mitochondri bioenerget common oxid phosphoryl relat diseas infanc neurolog sign patholog lesion leigh diseas mimick ablat mous mitochondri respiratori chain subunit nduf part crucial normal complex activ assembl particular brain children mice previous convey human nduf gene mous brain use either singl strand adeno associ viral recombin vector phpb adeno associ viral vector approach signific prolong lifespan nduf mous model extens surviv limit week former approach wherea latter applic limit number mous strain primat exploit recent develop new self complementari adeno associ viral vector transcript rate recombin gene mark increas compar singl strand adeno associ viral appli mammal includ human either singl intra vascular doubl intra vascular intra cerebro ventricular inject perform post natal day first strategi ubiquit convey human nduf gene product nduf mice doubl lifespan day birth mice develop rapid progress neurolog failur howev doubl contemporari intra vascular intra cerebroventricular administr self complementari adeno associ viral nduf prolong healthi lifespan month age mice well activ euthan month age investig brain organ post mortem robust express hnduf detect differ cerebr area preserv normal morpholog restor complex activ assembl result warrant investig translat self complementari adeno associ viral nduf base therapi prodrom phase diseas mice eventu human
|
D007888
|
T047
|
36,270,001
|
total synthesi dihydrooxepin spiroisoxazolin natur product psammaplysin report general synthet entri dihydrooxepin spiroisoxazolin dosi natur product culmin first racem total synthesi psammaplysin synthesi uniqu spirocycl fragment employ strategi featur two key transform diastereoselect henri reactioncycl sequenc access c hydroxyl isoxazolin scaffold one step regioselect baeyer villig ring expans instal fulli substitut dihydrooxepin avoid risk previous observ oxepin aren oxid rearrang overal synthesi proceed step inexpens start materi
|
D001688;D013141
|
T123;T121;T109
|
36,269,987
|
context analysi continu citat retract manuscript publish anesthesiolog journal continu citat retract public medic literatur well known persist problem describ context ongo citat manuscript retract select anesthesiolog journal also examin bibliograph databas publish websit document retract status manuscript author perform analysi retract public anesthesiolog journal use retract watch databas examin retract inform display bibliograph databas search engin publish websit primari outcom context continu citat retract flaw public within specialti anesthesiolog secondari outcom includ comparison document bibliograph databas search engin publish websit use identifi retract status public provis access respect retract notic total origin public retract year period anesthesiolog journal pubm compar databas search engin consist document retract status public examin well provid direct link retract notic public retract januari postretract citat access scopus median number postretract citat rang least citat public scopus postretract citat affirm valid retract public citat acknowledg retract misconduct citat origin research studi retract manuscript appear influenc decis pursu method use subsequ origin research studi frequenc citat cite retract public declin similar pattern year retract citat manuscript retract anesthesiolog journal remain common occurr technolog innov applic standard handl retract public suggest coalit research across spectrum scientif investig may serv reduc persist error
|
D000776;D010506;D015871
|
T091;T073;T080;T170;T068
|
36,269,982
|
opioid use disord pregnant patient issu anesthesia analgesia lim colleagu offer scope review avail literatur encompass opioid use disord oud pregnant patient discuss review opioid use abus pregnant patient increas four fold past decad patient present signific challeng respect pain manag labor deliveri baselin habitu opioid render patient resist convent pain manag plan addit prescrib opioid agonist antagonist mainten medic oud buprenorphin methadon even complex pharmacolog consider make pain manag unpredict detail analysi pauciti literatur surround optim manag strategi popul patient report increas time howev public lower tier evid random trial systemat review inform practition becom plain evid area clinic scienc demand greater attent specif area focus elabor author includ better character opioid select dose manag labor analgesia effect differ region anesthet techniqu non pharmacolog manag psycho social support patient reader strong encourag review cite articl depth understand concept summar infograph
|
D009293;D002047;D000777
|
T121;T039;T109;T048
|
36,269,979
|
move beyond pandem insight share experi two year resili human test coronavirus outbreak outset scientif communiti ralli best dissemin accumul knowledg real time contain outbreak sober lesson learn manag global crisi critic care anesthesiologist particular instrument decis maker insight reflect review may better prepar futur anoth virus spread scale sever member societi critic care anesthesiologist contribut special articl issu focus sever broad theme emerg manag pandem includ larg scale decis make health care system clinic manag new diseas resourc manag convers oper room intens care unit health care provid well consider summar infograph hearten see articl accompani editori issu address learn collect experi testament scientif communiti health care provid evolv overcom move beyond discourag prevail
|
D058873;D000086382
|
T047;T067
|
36,269,972
|
electron hydrodynam elimin landauer sharvin resist long realiz even perfect clean electron system harbor landauer sharvin resist invers proport number conduct channel resist usual associ voltag drop system contact extern circuit recent theori shown hydrodynam effect reduc resist rais question lower bound resist hydrodynam electron show proper choic devic geometri possibl spread landauer sharvin resist throughout bulk system allow complet elimin electron hydrodynam trace effect dynam electron flow channel termin within sampl ballist system termin lead back reflect electron creat resist hydrodynam scatter electron electron allow transfer transmit channel avoid resist counterintuit find contrast ohmic regim hydrodynam electron resist devic given width decreas length suggest long enough devic may arbitrarili small total resist
|
D004583;D057446
|
T081;T196;T070
|
36,269,961
|
intrins patholog self interact vector field show self interact vector field theori exhibit unphys behavior even coupl extern field mean theori featur vector danger unphys alarm prospect mani propos cosmolog graviti high energi physic beyond problem aris vector field healthi configur natur reach point time evolut mathemat ill defin develop tool easili identifi issu provid simpl unifi framework investig
|
D010825
|
T090
|
36,269,959
|
catalysi induc phase separ autoregul enzymat activ present thermodynam consist model describ dynam multicompon mixtur one enzym compon catalyz reaction compon find catalyt activ alon induc phase separ suffici activ system larg enzym without equilibrium interact compon limit fast reaction rate binod line calcul use map effect free energi also explain catalysi induc phase separ act autoregul enzymat activ point biolog relev phenomenon
|
D002384
|
T070
|
36,269,942
|
vaporspot parallel synthesi oligosaccharid membran autom chemic synthesi revolution synthet access biopolym term simplic speed autom oligosaccharid synthesi becom faster versatil parallel synthesi oligosaccharid yet possibl chemic vapor glycosyl strategi vaporspot describ enabl simultan synthesi oligosaccharid cellulos membran solid support differ linker allow flexibl straightforward cleavag purif character target oligosaccharid method basi develop parallel autom glycan synthesi platform
|
D009844
|
T109
|
36,269,936
|
enabl spectral resolv singl molecul local microscopi high emitt densiti singl molecul local microscopi smlm power super resolut techniqu elucid structur dynam life materi scienc simultan acquir spectral inform spectral resolv smlm ssmlm hamper sever challeng increas complex optic detect pathway lower access emitt densiti compromis spatio spectral resolut present singl compon low cost implement ssmlm address challeng use low dispers transmiss grate posit close imag plane st diffract order minim elong analyz use exist singl molecul local algorithm distanc th st order provid accur inform spectral properti individu emitt method enabl fold higher emitt densiti discrimin fluorophor whose peak emiss less nm apart approach find widespread use singl molecul applic reli distinguish spectral differ fluorophor low photon condit
|
D008853;D000072760
|
T059
|
36,269,910
|
augment realiti driven steadi state visual evok potenti wheelchair navig medic orient brain comput interfac bcis propos promis approach address individu suffer sever paralysi steadi state visual evok potenti ssvep particular proven success mani differ applic achiev high inform throughput short even train howev effici electr wheelchair navig combin high accuraci comfort still demonstr paper propos use ssvep base univers control system featur augment realiti ar glass attempt increas eas use patient accept without make compromis bci perform system receiv posit user feedback reach mean accuraci merit pitfal system propos also address
|
D000081411;D014910;D062207
|
T170;T074
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.