PMID
int64 35.7M
36.4M
| Title/Abstract
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|---|---|---|---|
36,271,560
|
cinnarizin dissolv microneedl microwav induc brain injuri microwav common use life manufactur militari field may induc bodi injuri brain major target organ microwav radiat microwav induc brain injuri mibi lead insomnia dreami declin learn memori howev clinic medic avail current calcium channel blocker may protect brain tissu microwav enter brain select calcium channel blocker cinnarizin prepar dissolv microneedl mns therapi mibi cinnarizin mns compos polyvinyl pyrrolidon pvp k tip photopolymer pvp base drug own high mechan strength lead easili piec skin neck high drug releas vivo cinnarizin mns mark improv recoveri spatial memori spontan exploratori behavior rat microwav radiat inhibit express calcineurin calpain dissolv mn techniqu promis method improv drug bodi perform anti microwav radiat action
|
D002936;D001930
|
T121;T037;T109
|
36,271,559
|
toll like receptor defici allevi lipopolysaccharid induc intestin barrier dysfunct intestin tract consid bodi engin impact organ sepsi studi explor toll like receptor tlr function sepsi induc intestin barrier dysfunct
|
D008070;D018805
|
T047;T046;T109
|
36,271,558
|
critic assess revis guidelin vancomycin therapeut drug monitor revis vancomycin guidelin recommend replac trough trough peaktrough bayesian first order equat monitor cite better auc predict poor auc trough r yet evid suggest good auc trough correl overlook optim peaktrough sampl doubt guidelin recommend bayesian program implement rich sampl poppk prior despit scarciti therefor whether complex bayesian sampl demand first order equat bring signific advantag practic simpl trough monitor worth weigh
|
D014640;D016903
|
T061;T058;T195;T116
|
36,271,557
|
resveratrol inhibit tgferk signal pathway improv atherosclerosi background mechan effect atherosclerosi patholog basi cardiovascular cerebrovascular diseas sever global public health problem contribut grow burden cardiovascular diseas due high risk limit therapeut measur treatment challeng requir doctor integr clinic manifest multipl risk factor complex lesion individu variabl signal transduct involv format progress transform growth factorextracellular regul protein kinas tgferk signal pathway involv pathophysiolog regul vascular smooth muscl cell prolifer inflammatori respons central link relat develop resveratrol exert benefici effect various stage develop regul lipid metabol inhibit inflammatori develop allevi oxid stress hypothes anti effect main modul tgferk signal pathway review summar current research progress resveratrol treatment via inhibit tgferk signal pathway present prospect
|
D016212;D050197
|
T123;T047;T046;T116
|
36,271,556
|
emt mechan breast cancer metastasi drug resist revisit molecular interact biolog function one malign tumor women involv develop develop countri breast cancer similar type tumor breast cancer cell demonstr high metastat natur besid breast tumor cell abil develop drug resist emt relat mechan cancer metastasi focus current manuscript highlight function emt breast tumor malign drug resist breast tumor cell increas migrat emt induct emt n cadherin vimentin level increas e cadherin level decreas mediat emt induc breast tumor invas differ kind anti cancer agent tamoxifen cisplatin paclitaxel emt induct mediat chemoresist featur breast tumor cell furthermor emt induct correl radio resist breast tumor clinic aspect revers emt prevent chemotherapi radiotherapi failur breast cancer patient improv surviv time anti tumor agent suppress emt use decreas breast cancer invas increas chemosensit tumor cell furthermor lncrnas mirna factor modul emt breast tumor progress discuss
|
D001943;D062085;D000970;D035683
|
T121;T123;T109;T191;T114
|
36,271,555
|
anti influenza virus activ agrimonia pilosa galla rhoi extract mixtur influenza virus iav continu threaten human health date two class antivir drug approv treat iav infect continu emerg drug resist iav mutant reinforc need develop new antivir drug studi aim investig anti iav activ aqueous mixtur agrimonia pilosa galla rhoi extract aprg demonstr aprg signific reduc iav induc cytopath effect transcriptionexpress viral protein product infecti viral particl among nine major compon aprg apigenin identifi main ingredi respons anti iav activ interest aprg apigenin inhibit cell attach entri virus polymeras activ import intranas administr aprg apigenin strong reduc viral load lung iav infect mice furthermor oral administr aprg signific reduc level viral rnas express level pro inflammatori cytokin lung protect mice iav induc mortal conclus aprg could attract antivir drug treat iav infect
|
D031981;D009980;D007251
|
T005;T002;T047
|
36,271,554
|
novel micropor resin base polym devic sustain glipizid releas product character pharmacokinet studi object studi explor innov sustain releas technolog design new micropor resin base polym devic rpd control releas glipizid gz photocur resin appli prepar resin layer control gz releas impact formul paramet consist type amount pore former ph modifi photocur cure time well weight resin layer gz releas examin gz rpd fabric appli mg resin layer peg resin weight pore former mg na co ph modifi scan electron microscopi sem demonstr resin particl present porous structur constitut resin layer gz rpd possess prolong max reduc c max relat commerci tablet relat bioavail rpds well commerci tablet sinc auc h nghml ng hml respect releas mechan gz rpd discuss paper provid innov concept produc control gz releas oral formul fabric photocur resin demonstr excel vitro releas vivo pharmacokinet
|
D005913;D011108
|
T121;T122;T104;T109
|
36,271,553
|
chemogenet inhibit mch neuron alter memori perform mice memori storag brain one extens studi subject neurosci howev due high complex structur memori relat system brain mysteri remain unsolv consolid one import part memori process one affect numer neurodegen diseas hypothalam melanin concentr hormon mch neuron activ particular interest research term associ sleep neurodegen diseas memori consolid use pmch cre anim investig role mch neuron activ memori consolid order observ differ memori consolid chemogenet inhibit mch neuron use dreadd method measur hippocampus depend memori perform novel object recognit test applic earli memori impair alzheim diseas result reveal signific improv worsen mch inhibit suggest role mch evalu wider set
|
D007028
|
T125;T116
|
36,271,552
|
protect effect lactococcus laudensi pediococcus parvulus neuropathi due amyloid beta caenorhabd elegan alzheim diseas ad amyloid protein begin accumul brain year prior dementia symptom manifest aggreg brain caus destruct nerv cell result memori impair lifestyl diet appear inhibit product amyloid deposit therefor identifi factor prevent product administ onset ad may effect prevent method lactic acid bacteria lab exhibit various health effect host expect protect effect neurolog function via brain gut correl howev protect effect lab well understood investig whether lab feed could amelior toxic peptid accumul transgen caenorhabd elegan express human peptid neuron muscl ad model express muscl caus myopathi worm paralysi neuron disturb chemotact activ among screen strain lactococcus laudensi pediococcus parvulus pp prevent ad worm lose chemotaxi behavior becom paralyz peptid immunostain western blot indic peptid signific suppress worm fed two strain bind vitellogenin particular inhibit convers mrna level gene chang pp fed worm control conclus pp allevi neurotox inhibit accumul ad model worm use screen effici lab ad prevent
|
D017173;D000544
|
T047;T204;T048
|
36,271,551
|
pectic polysaccharid aconitum carmichaelii leav protect dss induc ulcer coliti mice modul metabol microbiota composit industri process aconitum carmichaelii root use tradit chines medicin generat high amount wast materi especi leav acid polysaccharid fraction isol unutil leav al previous work shown contain pectic polysaccharid studi aim investig protect effect al ulcer coliti possibl applic carmichaelii leav treatment intestin inflammatori diseas al found allevi symptom colon patholog injuri coliti mice amelior level inflammatori indic serum colon product short branch chain fatti acid also restor al observ protect effect could due inhibit nod tlr activ promot gene transcript tight junction protein modul gut microbiota composit like bacteroid dubosiella alistip prevotella regul serum metabolom profil relev bacteri chang mannos phosphat erythros phosphat uric acid also observ
|
D031841;D003093;D003092;D064307
|
T121;T032;T109;T001;T131;T028;T047;T002
|
36,271,550
|
ganoderma microsporum immunomodulatori protein act multifunct broad spectrum antivir sar cov interf virus bind host cell spike mediat cell fusion sever acut respiratori syndrom coronavirus sar cov high transmiss coronavirus caus million fatal sar cov variant spike mutat frequent endow strong capabl escap vaccin elicit protect due characterist broad spectrum inhibitor sar cov infect urgent demand ganoderma microsporum immunomodulatori protein gmi previous report allevi infect sar cov ace downregul wherea impact gmi virus less understood studi aim determin effect gmi sar cov pseudovirus detail mechan gmi inhibit sar cov pseudovirus infect
|
D000086402;D000086382
|
T005;T067;T047
|
36,271,549
|
age depend associ discharg heart failur medic clinic outcom super age societi real world evid heart failur hf medic care elder patient limit aim studi clarifi age depend associ hf medic discharg clinic outcom super age societi use real world big databas
|
D057911;D006333
|
T121;T047;T046
|
36,271,548
|
character activ mechan action new toluquinol deriv improv potenti antiangiogen drug inhibit sustain angiogenesi attract approach treatment cancer blind angiogenesi depend diseas encourag previous find toluquinol methyl hydroquinon isol marin fungus exhibit interest antiangiogen activ explor structur modif natur compound order develop improv drug candid result indic although methyl group play relev role cytotox activ toluquinol deriv methyl replac anoth substitu could keep antiangiogen activ wherea exhibit lower cytotox vitro case e methoxyprop en yl benzen diol exhibit decreas toxic wherea maintain even improv antiangiogen activ toluquinol demonstr number vitro endotheli cell prolifer migrat tube format vivo chick embryo chrorioallanto membran vascular murin corneal neovascular experiment approach result point mechan action could relat induct apoptosi well increas reactiv oxygen speci level reduct redox capac inhibit vegfr akt erk phosphoryl vegf activ endotheli cell biolog activ new angiogenesi inhibitor along lower undesir toxic suggest promis drug candid improv potenti treatment angiogenesi relat diseas
|
D020533;D006873
|
T123;T121;T116;T109;T039
|
36,271,547
|
phytotherapeut applic alkaloid treat breast cancer breast cancer one major caus mortal women worldwid current treatment avail radiat therapi rt surgeri endocrin hormon therapi et chemotherapi ct target therapi treatment associ certain side effect demand use natur compound due lower neglig side effect one categori natur compound alkaloid alkaloid group natur compound gain widespread attent due use potenti therapeut alkaloid exert anti inflammatori antivir properti along antimicrobi activ current review alkaloid review detail potenti treat breast cancer alkaloid shown induc apoptosi decreas tumor volum inhibit cell prolifer migrat induc autophagi also use compon combin therapi review provid comprehens inform vitro vivo therapeut abil alkaloid counteract breast cancer
|
D001943;D000470;D000890
|
T121;T123;T109;T131;T191
|
36,271,546
|
calycosin modul nlrp txnip mediat pyroptot signal attenu diabet nephropathi progress diabet rat insight diabet nephropathi dn one preval microvascular complic diabet mellitus dm consid lead caus kidney failur studi calycosin isoflavon constitut major constitu radix astragali numer pharmacolog merit investig reno protect agent dn also potenti under mechan investig streptozotocin stz mgkg inject periton caviti male spragu daw rat induc dm ten week calycosin mgkg nac mgkg oral administ signific lower blood glucos level signific increas insulin level calycosin improv deterior kidney function evidenc retract serum creatinin albuminuria blood urea nitrogen proteinuria level meanwhil urin creatinin clearanc signific escal furthermor biomark cell injuri ldh activ signific declin kidney content mark decreas well inflamm fibrosi oxid stress manifest increas serum level il renal nf bp nlrp txnip mda content declin level il tac decreas nrf express mention biomark signific improv calycosin treatment modul nf bpnlrptxnip signal oxid stress inflammatori cytokin fibrot process thus impli reno protect impact associ improv renal histopatholog immun histopatholog paramet h e masson trichrom nrf base find calycosin presum promis drug hinder develop dn modul nf bpnlrptxnip inflammasom signal pathway
|
D003928;D003921;D007529;D061385
|
T121;T047;T050;T109
|
36,271,545
|
yap novel target regul f actin rearrang associ caf transform promot colorect cancer cell progress colorect cancer crc progress strong influenc tumor microenviron tme cancer associ fibroblast caf major compon influenc crc growth progress present studi aim investig effect yap f actin arrang caf transform possibl use yap target inhibit crc growth progress condit media collect direct interact crc cell fibroblast caf marker investig flow cytometri western blot analysi immunofluoresc assay cm treat fibroblast promot crc progress condit media determin crc cell use mtt assay fluoresc assay wound heal assay transwel migrat assay tubulogenesi result show condit media induc express caf marker associ central rearrang f actin colon fibroblast upregul promot nuclear transloc yap condit media also signific promot prolifer migrat invas angiogenesi crc cell interest verteporfin yap inhibitor cocultiv abolish convers caf inhibit prolifer migrat invas angiogenesi crc cell moreov bioinformat analysi employ determin potenti role yap prognost marker crc patient databas result suggest yap higher express crc patient associ poor prognosi conclus find demonstr yap relat f actin rearrang may potenti new target combin therapi focus target tme
|
D000072645;D015179
|
T191;T025
|
36,271,544
|
pristan attenu atherosclerosi apo mice via il secret regulatori plasma cell mediat macrophag polar atherosclerosi inflammatori progress vascular diseas caus heart diseas stroke worldwid b cell immun suppress function implic autoimmun inflammatori cardiovascular diseas howev precis role regulatori b cell interact macrophag atherosclerosi remain undefin studi eight week old femal apolipoprotein e null apo mice treat singl dose vehicl pristan place atherogen diet week found pristan decreas atherosclerot lesion format increas stabil atherosclerot plaqu apo mice also observ lower frequenc cd b cell higher frequenc cd plasma cell cd macrophag apo mice treat pristan import pristan inhibit immun cell infiltr vascular wall upregul il bone marrow cd plasma cell pristan treat apo mice demonstr rna sequenc rna seq consist oxid low densiti lipoprotein oxldl direct induc il secret plasma cell generat vitro co cultur system incub anti il neutral antibodi result show oxldl induc cd plasma cell could boost macrophag polar via il secret data demonstr unexpect role pristan induc il produc cd regulatori plasma cell generat polar protect atherosclerosi develop
|
D050197;D058226
|
T047;T046;T020;T031
|
36,271,543
|
endoplasm reticulum stress melanoma pathogenesi resist melanoma lethal skin cancer rise incid worldwid despit signific advanc target therapi immunotherapi low respons rate develop drug resist remain key clinic barrier affect patient prognosi complex interplay multipl signal molecul pathway brought littl understand melanoma pathogenesi resist genet mutat hypermetabol environ melanoma cell lead increas demand protein synthesi perturb proteostasi result endoplasm reticulum er stress subsequ three unfold protein respons upr signal branch repres ire perk atf activ direct cell fate toward pro surviv pro apoptosi depend intens durat er stress review summar er stress upr melanoma cell tumor infiltr immun cell along crosstalk among pathway provid latest advanc understand melanoma pathogenesi resist discuss potenti target er stress upr process melanoma therapi
|
D059865;D008545
|
T049;T191
|
36,271,542
|
inhibit pancreat cancer cell growth metastasi vivo pyrazol compound character cell migrat inhibitor vitro chemotaxi assay pancreat cancer recalcitr treatment high metastat rapid progress observ behavior human pancreat bxpc cell use optic assay devic call taxiscan found sever synthet pyrazol pyrimidin deriv inhibit cell migrat one compound inhibit metastasi fluoresc label bxpc cell transplant pancrea nude mice subcutan grown cancer fragment surpris despit low cytotox compound also show inhibitori effect cancer cell prolifer vivo suggest compound alter cancer cell characterist need grow situ singl cell rna sequenc reveal chang gene express associ metastasi angiogenesi inflamm epitheli mesenchym transit data suggest compound could good drug candid pancreat cancer
|
D002633;D010190
|
T191;T038;T043
|
36,271,541
|
artesun promot anti tumor immun overcam egfr tki resist non small cell lung cancer enhanc oncogen taz degrad lung cancer lead caus cancer relat death worldwid develop epiderm growth factor receptor tyrosin kinas inhibitor egfr tkis immun checkpoint inhibitor ici brought favor surviv benefit patient non small cell lung cancer nsclc unfortun acquir drug resist remain major barrier treatment nsclc recent studi demonstr transcript co activ pdz bind motif taz also call wwtr induc tumor immun evas direct modul express program death ligand pd l key therapeut target checkpoint immunotherapi moreov aberr activ taz also major mechan acquir resist egfr tkis nsclc therefor taz signal blockad might effect strategi overcom resist ici egfr tkis nsclc studi show rst time artesun effect reduc taz pd l express nsclc demonstr artesun suppress tazpd l induc cell growth inhibit vitro enhanc anti tumor immun recruit infiltr cd cell syngen mous model artesun also inhibit stem cell like properti nsclc cell suppress tumor growth xenograft bear gefitinib resist tumor addit result molecular dock cellular thermal shift assay analysi suggest artesun might direct target taz tead complex induc proteasom depend taz degrad nsclc cell result suggest artesun enhanc anti tumor immun overcam egfr tki resist nsclc least part suppress tazpd l signal
|
D002289;D008175
|
T191
|
36,271,540
|
panax notoginseng saponin allevi inflamm induc microgli activ protect ischem brain injuri via inhibit hif pkmstat signal panax notoginseng saponin pns main activ ingredi herbal medicin panax notoginseng general appli therapi cardiovascular cerebrovascular diseas especi stroke believ pns obvious anti inflammatori effect howev role pns microglia stroke complet explor under mechan microglia mediat inflamm remain clarifi studi cerebr ischemia injuri induc photothrombot pt stroke mice two day oper pns administr allevi ischem brain injuri increas grip strength reliev neurolog deficit improv local cerebr blood flow reduc patholog damag brain cortex hippocampus moreov microgli activ occur acut stage stroke mediat inflamm wherea pns administr could inhibit microgli activ inflamm meanwhil first demonstr pkm express upregul nucleus activ microglia stroke could inhibit pns administr hypothes suppress nuclear pkm upregul microglia along downregul hif pkmstat signal could partial underli potenti anti inflammatori mechan pns ischem brain injuri find offer new standpoint pns microglia mediat inflamm stroke despit strength studi limit pkm specif express microglia could express neuron vascular endotheli cell etc explor effect pkm activ microglia would investig impact pkm express cell stroke outcom futur
|
D053723;D012503;D020521;D001930
|
T047;T037;T002;T109
|
36,271,539
|
anti inflammatori anti oxid properti ipomoea nil linn roth signific allevi cigarett smoke cs induc acut lung injuri via possibl inhibit nf b pathway acut respiratori distress syndrom ard serious manifest acut lung injuri ali debilit inflammatori lung diseas caus multipl risk factor one primari caus lead aliard cigarett smoke cs primari mode action via oxid stress despit extens research appropri therapi current avail treat aliard mean dire need new potenti approach studi explor protect effect methanol aqueous extract ipomoea nil linn roth name inmcx cs induc ali mice model raw macrophag ipomoea nil tradit use treat breath irregular male swiss albino mice g subject cs uninterrupt day order establish cs induc ali murin model dexamethason mgkg inmcx mgkg normal salin mlkg given respect anim group h cs exposur h last cs exposur lung bronchoalveolar lavag fluid balf euthan mice harvest alter alveolar integr elev lung weight coeffici total inflammatori cell oxid stress express pro inammatori cytokin il il chemokin kc signific decreas inmcx cs expos mice inmcx also reveal signific lower il il kc express cse activ raw macrophag addit inmcx show mark enzym inhibit activ acetylcholinesteras butyrylcholinesteras lipoxygenas import inmcx dose depend remark suppress cs induc oxid stress via reduc mpo tos mda content also improv tac product lung accord hplc analysi reveal presenc mani import antioxid compon final inmcx show mark decreas nf b express vivo vitro model find suggest inmcx posit therapeut effect cs induc ali via suppress uncontrol inflammatori respons oxid stress lipoxygenas nf b p pathway
|
D049915;D000073865;D055371;D012128
|
T055;T047;T037;T002
|
36,271,510
|
ghrabac coordin cell elong via regul actin filament depend vesicl transport plant cell expand via tip growth diffus growth mode plant raba largest group rab gtpase regul vesicl traffick function raba protein modul polar expans tip growth cell demonstr howev whether raba protein function diffus growth plant cell never explor address question examin role ghrabac cotton fiber ghrabac preferenti express elong fiber protein local endoplasm reticulum golgi apparatus express ghrabac cotton lead longer shorter fiber respect ghrabac interact ghact promot assembl actin filament facilit vesicl transport cell wall synthesi consist ghrabac overexpress fiber exhibit increas content wall compon transcript level gene respons synthesi cell wall materi identifi two myb protein direct regul transcript ghrabac collect data show ghrabac promot diffus cell expans support vesicl traffick cell wall synthesi
|
D032561;D008841
|
T026;T167
|
36,271,509
|
dose depend phosphoryl activ hh pathway transcript factor grade hedgehog hh signal mediat grade cubitus interruptus ci gli transcript activ hh gradient convert cig activ gradient remain poor understood show grade hh induc progress increas ci phosphoryl multipl fuse fu ck site includ cluster locat c termin sufu bind domain demonstr fu direct phosphoryl ci prime ck phosphoryl adjac site fuck mediat phosphoryl c termin site interf sufu bind facilit ci activ phosphoryl n termin middl c termin fuck site occur independ one anoth increas progress respons increas level hh increas amount hh exposur time increas number phospho mimet mutat fuck site result progress increas ci activ allevi sufu mediat inhibit found c termin fuck phosphoryl cluster conserv gli contribut dose depend activ studi suggest hh signal gradient translat cig phosphoryl gradient activ cig gradual releas sufu mediat inhibit
|
D014157;D029721
|
T123;T116
|
36,271,507
|
mechanist pharmacodynam studi duobodi cdxt preclin tumor model cd bispecif antibodi bsab show great promis anticanc therapeut show depth mechanist studi cd bsab solid cancer use duobodi cdxt cross link cell tumor cell express oncofet antigen requir induc cytotox naiv memori cd cd cell equal effect mediat cytotox duobodi cdxt induc partial differenti naiv cell subset memori like cell tumor cell kill associ cell activ prolifer product cytokin granzym b perforin genet knockout fas ifngr tumor cell abrog tumor cell kill presenc tumor cell bystand kill ifngr tumor cell observ human xenograft model duobodi cdxt antitumor activ associ intratumor peripher blood cell activ last dissoci patient deriv tumor sampl duobodi cdxt activ tumor infiltr lymphocyt induc tumor cell cytotox even tumor infiltr lymphocyt express pd data provid depth view mechan action cd bsab preclin model solid cancer
|
D018033;D009369
|
T129;T121;T191;T116
|
36,271,504
|
mitochondri stress induc gfral signal control diurnal food intak anxieti like behavior growth differenti factor gdf mitochondri stress induc cytokin modul energi balanc endocrin manner howev import brainstem restrict receptor gdnf famili receptor alpha like gfral mediat endocrin gdf signal brain upon mitochondri dysfunct still unknown use mous model muscl specif mitochondri dysfunct show gfral requir activ system energi metabol via daytim restrict anorexia respons muscl wast find muscl mitochondri stress respons involv gfral depend induct hypothalam corticotropin releas hormon without elev corticosteron level final identifi gfral signal govern anxieti like behavior male mice muscl mitochondri dysfunct femal show less robust gfral depend anxieti like phenotyp togeth provid novel evid mitochondri stress induc muscl brain crosstalk via gdf gfral axi modul food intak anxiogen behavior
|
D055436;D009765
|
T129;T047;T116
|
36,271,499
|
hiv infect enhanc innat function tlr express femal plasmacytoid dendrit cell plasmacytoid dendrit cell pdcs express tlr ssrna sensor encod x chromosom escap x chromosom inactiv xci femal pdcs special product type interferon ifn tlr activ mediat immun cell activ also reactiv latent hiv effect hiv infect women antiretrovir therapi art pdc function respons remain poor understood show pdcs hivart women exhibit exacerb product ifn tnf compar uninfect control uc upon tlr activ tlr escap xci femal pdcs measur contribut tlr allel express use snp haplotyp marker rigor tag allel origin tlr gene singl cell resolut herein provid evid enhanc function respons pdcs hivart women associ higher transcript activ tlr locus x chromosom rather differ frequenc tlr biallel cell data reinforc interest target hiv reservoir use tlr agonist women
|
D015497;D015658
|
T005;T047
|
36,271,494
|
meiotic dna break activ streamlin phospho signal respons larg avoid protein level chang meiotic cell introduc numer program dna break genom stimul meiotic recombin ensur control chromosom inherit fertil checkpoint network involv key kinas phosphatas coordin repair dna break precis phosphoryl target remain poor understood also unknown whether meiotic dna break chang gene express akin canon dna damag respons address question analyz meiotic dna break respons saccharomyc cerevisia use multipl system level approach identifi dna break depend phosphoryl site vast expand number known event meiotic prophas less half event occur recognit motif known meiotic checkpoint kinas mec atr tel atm mek chk suggest addit kinas contribut meiotic dna break respons detect clear transcript program detect chang protein level attribut dichotomi decreas transcript level meiotic entri dampen effect break induc transcript suffici caus minim chang meiotic proteom
|
D008540;D029701
|
T116;T043
|
36,271,492
|
human rna polymeras structur reveal hmg like dock domain specif metazoan transcript ribosom rna precursor rna polymeras pol major determin cellular growth dysregul observ mani cancer type present purif human pol cell carri genom gfp fusion largest subunit allow structur function analysi enzym across speci contrast yeast human pol carri singl subunit stalk vitro transcript indic reduc proofread activ determin human pol cryo em reconstruct close nativ state ration effect diseas associ mutat uncov addit domain built sequenc pol subunit rpa dock ii domain resembl truncat hmg box incap dna bind may serv downstream transcript factor bind platform metazoan biochem analysi situ model chip data indic topoisomeras recruit pol via domain cooper hmg box domain contain factor ubf adapt metazoan pol transcript system may allow effici releas posit dna supercoil accumul downstream transcript bubbl
|
D012318;D012322
|
T123;T126;T116;T114
|
36,271,470
|
screen fabri diseas high risk subpopul fmf famili mediterranean fever fmf autosom recess diseas associ mutat mediterranean fever gene mefv manifest recurr episod febril seros fabri diseas fd x link lysosom storag diseas caus mutat alpha galactosidas gene present wide rang gastrointestin skin vascular renal neurolog manifest fmf fd share similar manifest may lead misdiagnosi one most fd misdiagnos fmf moreov various overlap manifest may stem comorbid common coupl fmf behcet diseas inflammatori bowel diseas glomerulonephr fibromyalgia multipl sclerosi well colchicin advers effect may add diagnost confus thus postul screen fmf fd lead identif patient fals diagnos fmf addit fmf suffer fd previous miss
|
D010505;D000795
|
T047
|
36,271,469
|
rs multipl immunolog trait suscept locus cd regul product non function splice isoform ligat cd ligand cd cd provid critic second signal alongsid antigen present class ii major histocompat complex express antigen present cell cell antigen receptor nave cell activ number studi suggest cd play import role pathogenesi various human diseas recent genom wide associ studi gwass identifi cd suscept locus lymphocyt eosinophil count multipl sclerosi ulcer coliti celiac diseas rheumatoid arthriti asthma primari biliari cholang howev primari function variant molecular mechan diseas suscept locus remain elucid studi aim identifi primari function variant thousand genet variant cd locus elucid function effect cd molecul
|
D018106;D055106
|
T063;T129;T116;T192
|
36,271,467
|
nomogram predict sclerotherapi respons treatment lymphat malform children manuscript purpos identifi prognost factor treatment lymphat malform children use polidocanol foam combin pingyangmycin construct nomogram predict sclerotherapi respons
|
D015911;D044148
|
T061;T190
|
36,271,455
|
patient journey resourc map implement praziquantel mass drug administr program children age year resourc limit set earli childhood develop million children low medium incom countri may compromis schistosomiasi infect contract age year current standard guidelin treat schistosomiasi children year younger use praziquantel pzq drug world health organ recommend treat schistosomiasi review process resourc involv treatment schistosomiasi children age year
|
D000871;D012552;D064420
|
T121;T047;T046;T037
|
36,271,454
|
nidogen could play role diabet kidney diseas develop type diabet genom wide associ meta analysi diabet kidney diseas dkd affect patient diabet incur usual lead end stage renal diseas esrd pathogenesi dkd still fulli understood genet dkd yet extens studi studi investig genet basi dkd type diabet td provid insight pathogenesi diseas
|
D003924;D003928;D008562
|
T123;T047;T116
|
36,271,453
|
efficaci safeti tripterygium wilfordii polyglycosid diabet kidney diseas overview systemat review meta analys recent sever systemat review srs meta analys mas tripterygium wilfordii polyglycosid twp report signific benefit diabet kidney diseas dkd howev adopt twp dkd remain uncommon studi aim evalu summar current evid twp dkd
|
D003928;D029757
|
T047;T002
|
36,271,452
|
neuron desertif direct lightn strike case report lightn strike rare dramat caus injuri patient admit intens care unit icus lightn strike frequent high mortal signific long term morbid relat direct brain injuri induc cardiac arrest ca
|
D015168;D008030;D001930
|
T070;T037
|
36,271,451
|
build capac west african countri aed surveil inaugur meet west african aed surveil network waasun arbovir diseas dengu zika chikungunya transmit aed mosquito report african countri avail data indic recent year dengu chikungunya outbreak west africa subregion countri includ cte divoir burkina faso gabon seneg benin viral diseas caus increas public health burden imped poverti reduct sustain develop aed surveil control capac key reduc preval arbovir infect need strengthen west africa provid inform essenti formul effect vector control strategi predict arbovir diseas outbreak line object west african aed surveil network waasun creat meet held sierra leon compris african scientist work aed mosquito manuscript describ proceed discuss key highlight meet
|
D000330;D065632;D001102;D000071243;D000071244;D003715
|
T047;T005;T204
|
36,271,450
|
interleukin defici prevent biliari injuri repair caus clonorchi sinensi via restrain type cytokin clonorchiasi caus clonorchi sinensi zoonot parasit diseas character cholang biliari prolifer biliari fibrosi even cholangiocarcinoma previous studi show express interleukin il increas human mice infect c sinensi suggest il potenti involv pathogenesi clonorchiasi howev role potenti mechan il under remain unknown
|
D003003;D003004;D018793
|
T129;T047;T116;T204
|
36,271,449
|
adher hour movement guidelin among rural brazalian preschool children associ parent practic young children resid rural area low middl incom countri lmic brazil greater risk obes relat chronic health condit yet extent rural preschool children brazil age year meet world health organis hour movement guidelin unknown parent play central role develop children movement behavior logist support co particip model set rule limit recogn influenti parent practic howev bulk parent research conduct famili high incom countri hic littl known relationship parent practic children movement behavior lmic communiti therefor aim studi two fold report proport preschool children low incom famili rural brazil meet hour movement guidelin determin associ theori base parent practic relat physic activ screen time sleep
|
D057185;D016487
|
T033;T079;T054
|
36,271,447
|
insecticid effect select plant extract anophel stephensi culicida diptera use synthet insecticid mosquito may lead resist develop potenti health hazard human environ consequ paradigm need shift toward altern use botan insecticid could strengthen insecticid resist manag programm studi aim assess insecticid effect aqueous hexan methanol crude leaf extract calpurnia aurea momordica foetida zehneria scabra insectari coloni anophel stephensi larva adult
|
D000852;D007306;D009033;D003465;D000330
|
T131;T204
|
36,271,446
|
longitudin assess prepar care transit among adolesc young adult rheumatolog diseas singl center pilot studi adolesc young adult aya rheumatolog diseas high risk poor outcom gap care transit pediatr adult care howev tool evalu transit readi assess impact transit intervent limit implement written transit polici pediatr rheumatolog center evalu prepar transit among aya older distribut patient complet follow survey respons rate patient report transit counsel increas follow written transit polici implement though result statist signific small cohort follow respond n yet complet care transfer arrang visit adult rheumatologist fulli transit adult care success complet care transfer older complet higher level educ signific higher baselin transit prepar score compar transfer arrang plan visit singl center pilot studi demonstr longitudin assess transit prepar feasibl score signific associ care transfer outcom track transit prepar time may provid practic inform area highest need transit guidanc predict success transfer among aya rheumatolog diseas
|
D060305;D012219;D001172
|
T058;T091;T047
|
36,271,445
|
anterior cruciat ligament injuri postop outcom associ polymorph cola rs gt case control studi middl east elit athlet unclear role cola polymorph play anterior cruciat ligament acl injuri pathophysiolog present studi investig relationship cola guanin g thymin rs polymorph acl injuri moreov possibl effect polymorph postop outcom acl reconstruct surgeri evalu
|
D000070598;D000090602
|
T123;T116;T037
|
36,271,441
|
induc labour limit risk pregnanc hypertens multicentr randomis control trial adapt deliv time birth trial covid intern pandem pragmat randomis time birth trial adapt trial procedur respons covid pandem review inform post pandem trial methodolog
|
D000086382;D007743;D006973
|
T047;T040;T067
|
36,271,436
|
suscept primari secondari suspect vector plasmodium vivax plasmodium falciparum infect ethiopia insecticid base vector control intervent combin case manag artemisinin base combin therapi reduc malaria incid preval worldwid current control method focus primari malaria vector anophel gambia sensu lato sl funestus group howev impact secondari suspect vector either sidelin receiv limit attent defin suscept secondari suspect vector speci differ parasit time space essenti effici malaria control elimin program aim studi assess suscept gambia sl coustani complex pharoensi plasmodium vivax p falciparum infect ethiopia
|
D007306;D016778;D000852;D016780;D008288;D037621
|
T131;T047;T204;T109
|
36,271,434
|
cross section studi simulium damnosum sensu lato breed site speci distribut sudan savanna mix savanna forest rainforest region cameroon presenc breed site distribut speci simulium damnosum sensu lato critic understand epidemiolog onchocerciasi evalu impact elimin intervent report breed site speci distribut member damnosum sl cameroon scarc one avail date back three decad aim studi provid inform damnosum breed site across raini rs dri ds season speci composit three differ region cameroon southwest sw northwest nw north n
|
D012843;D009855
|
T047;T204
|
36,271,432
|
choic made educ decis regress dictat discurs frame propos sugar tax bermuda analysi submiss govern consult sever govern introduc tax product high sugar content part obes prevent strategi bermuda first jurisdict appli measur caribbean region small island develop state territori high obes preval substanti relianc import food product studi examin commerci health actor frame propos introduct import tariff high sugar product base written submiss bermudan govern
|
D000073893;D013660
|
T081;T121;T064;T109
|
36,271,430
|
tick microbi associ crossroad horizont vertic transmiss pathway microbi communiti affect diseas risk interf transmiss mainten pathogen blood feed arthropod investig whether bacteri communiti vari ixod ricinus nymph infect horizont transmit human pathogen
|
D018884;D012281;D041081;D025065;D000710
|
T007;T204
|
36,271,429
|
cancer bench bedsid protein belong erbbher receptor tyrosin kinas rtk famili express sever type tumor fact togeth role promot cell prolifer implic target may therapeut relev furthermor express activ link resist drug target receptor agent act egfr addit associ resist chemotherapeut drug circumst effort develop test agent target carri two type agent target develop abund antibodi engin antibodi deriv specif recogn extracellular region addit use aptam specif interact vaccin target sirna also develop discuss state art preclin clinic develop drug aim target therapeut purpos
|
D009369;D020893
|
T191;T116;T192
|
36,271,428
|
thoracolumbar fascia mobil chronic low back pain phase pilot feasibl studi includ multimod chiropract care thoracolumbar fascia mobil observ ultrasound imag calcul shear strain lower person chronic low back pain pilot feasibl trial assess thoracolumbar shear strain person chronic low back pain follow spinal manipul week cours multimod chiropract care
|
D002684;D017116;D020393
|
T061;T184;T047;T091
|
36,271,427
|
scale sever acut malnutrit treatment communiti health worker geospati coverag analysi rural mali ministri health mali includ treatment sever acut malnutrit sam packag activ integr communiti case manag iccm paper aim analyz impact includ communiti health worker chws treatment provid outsid health facil hfs coverag sam treatment scale intervent three largest district kay region mali
|
D003150;D000067011
|
T047;T102;T097
|
36,271,426
|
work product activ patient sapho syndrom cross section observ studi understand work product impair among patient synov acn pustulosi hyperostosi osteiti sapho syndrom limit purpos studi provid overview work product loss sapho syndrom patient use work product activ impair wpai questionnair well investig relationship wpai diseas relat indic
|
D020083
|
T047
|
36,271,425
|
concomit elev serum level tenascin mmp ykl suggest ongo remodel heart month cardiac surgeri normal revascular marker recoveri cardiac surgeri involv resolv inflamm remodel signific connect tissu turnov dynam smolder inflamm injuri white blood cell platelet crp il il vascular inflamm il vegf rant connect tissu remodel tenascin mmp cardiac injuri remodel ykl vascular remodel epiregulin mcp vegf assess month cardiac surgeri hypothes month studi marker return pre surgic level
|
D020780;D006348
|
T061;T126;T116
|
36,271,424
|
patient view gene therapi develop lysosom storag disord qualit studi sever new treatment modal develop lysosom storag disord lsds includ gene therapi current avail treatment option influenc diseas progress differ great within spectrum lsds willing undergo gene therapi might vari among patient lsds andor repres width lsd spectrum illustr differ type gaucher diseas fabri diseas mucopolysaccharidosi type iii mps iii type gaucher fabri diseas sever therapi avail result near normal improv individu vari prognosi treatment option avail mps iii
|
D000795;D005776;D016464;D009084
|
T047
|
36,271,422
|
hous screen malaria control view experi particip roopf trial hous stock rural sub saharan africa chang rapid million new home requir come decad opportun protect resid screen home malaria mosquito studi undertaken upper river region gambia explor local percept good hous provid inhabit respons live hous modifi part random control trial design assess whether improv hous provid addit protect clinic malaria children roopf trial
|
D000852;D008288
|
T047;T204
|
36,271,420
|
random phase trial intraven oncolyt virus jx combin low dose cyclophosphamid patient advanc soft tissu sarcoma jx oncolyt vaccinia virus genet modifi replic select tumor cell metronom chemotherapi shown preclin synergi oncolyt virus report result metromajx random phase ii clinic trial investig combin jx combin metronom cyclophosphamid arm metronom cyclophosphamid arm patient advanc sts two stage simon design use jx administ intra venous dose everi week first inject everi week cyclophosphamid given oral dose mg bid week week primari endpoint month non progress rate patient includ arm arm two frequent toxic grade fatigu fever grade fatigu grade lymphopenia arm respect arm patient assess efficaci analysi none progress free month indic first stage simon design satisfi one patient assess efficaci progress free month arm high throughput analysi sequenti plasma sampl reveal upregul protein biomark reflect immun induct cxcl solubl cd antigen arm system treatment jx safe patient advanc sts investig need improv immun respons oncolyt virus defin therapeut potenti patient sts
|
D050504;D012509
|
T005;T191
|
36,271,419
|
dehydr associ product organ osmolyt predict physic long term symptom covid multicent cohort studi previous shown iatrogen dehydr associ shift organ osmolyt product general icu popul aim present investig determin valid physiolog respons dehydr known aestiv relev long term diseas outcom covid
|
D000086382
|
T047;T067
|
36,271,418
|
increas rate cyclop lesion extens deficit remnant preserv acl reconstruct use spare techniqu remnant preserv anterior cruciat ligament reconstruct aclr advantag postop remodel propriocept howev suggest larger diamet graft tend lead imping phenomena higher rate cyclop lesion aim work find whether remnant preserv aclr actual lead increas rate rang motion restraint compar remnant sacrif techniqu
|
D016118;D008911
|
T121;T023;T195;T109
|
36,271,417
|
predictcbc contralater breast cancer risk predict model develop valid patient predict contralater breast cancer cbc risk challeng due moder perform known risk factor aim improv previous risk predict model predictcbc updat follow includ addit risk factor
|
D001943;D000072036
|
T061;T191
|
36,271,415
|
societ driver human echinococcosi china echinococcosi parasit zoonot diseas threaten human health econom develop china counti endem echinococcosi qinghai tibet plateau patient peopl risk therefor analyz societ factor relat suscept diseas critic effici prevent control echinococcosi
|
D004443
|
T047
|
36,271,414
|
gossypetin amelior xfad spatial learn memori enhanc phagocytosi microglia resid immun cell found brain critic role brain mainten microglia constant scaveng various wast materi brain includ damag apoptot neuron phagocytosi microglia prevent accumul plaqu brain howev alzheim diseas ad patient chronic exposur make microglia becom exhaust reduc phagocyt activ sinc microglia play import role clearanc enhanc microgli phagocyt activ promis target ad treatment therefor great need therapeut candid enhanc microgli clearanc inhibit microglia pathogen properti
|
D065853;D000544
|
T047;T041;T048
|
36,271,412
|
delay pharyngocutan fistula caus molecular target therapi case report molecular target agent use treatment cancer caus rare serious advers event delay wound heal depend anticanc drug use temporari withdraw may recommend surgeri avoid complic surgic incis heal close complet wound rare open initi molecular target therapi sever month year surgeri aim describ rare complic pharyngocutan fistula two patient thought caus molecular target therapi
|
D017577;D010608;D007822
|
T047;T191;T190
|
36,271,410
|
oxygen target month outcom hospit cardiac arrest pre plan sub analysi target hypothermia versus target normothermia hospit cardiac arrest ttm trial optim oxygen target patient resuscit cardiac arrest uncertain primari aim studi describ valu partial pressur oxygen valu pao episod hypoxemia hyperoxemia occur within first h mechan ventil hospit cardiac arrest ohca patient secondari aim evalu associ pao patient outcom
|
D007035;D058687
|
T033;T046;T037
|
36,271,409
|
extrem activ nano formul resveratrol xar attenu revers chemotherapi induc damag mice ovari test fertil preserv restor cancer patientssurvivor need present time increas number patient get cure cancer face infertil serious side effect resveratrol benefici effect chemoabl ovari test mice fail enter clinic extrem poor bioavail present studi undertaken evalu protect curat effect extrem activ resveratrol xar nano formul resveratrol signific improv bioavail mous ovari testi chemotherapi effect xar fsh compar stimul follicl growth adult mice ovari xar mgkg administ two day prior chemotherapi studi protect effect mous gonad xar also administ day post chemoabl studi regen effect besid effect number primordi grow follicl spermatogenesi effect xar also evalu transcript specif ovariantesticular stemprogenitorgerm cell prolifer differenti meiosi antioxid indic
|
D013737;D000970
|
T121;T023;T109
|
36,271,408
|
factor affect reproduct perform swedish bernes mountain dog good reproduct perform fundament develop breed previous studi indic bernes mountain dog relat high preval reproduct problem high preval dystocia low mean litter size reproduct impair select trait includ improv health becom difficult aim studi therefor evalu reproduct data factor affect bernes mountain dog data collect swedish sennenhund club year evalu statist analys
|
D050497;D004283
|
T033;T047
|
36,271,407
|
dpr noct requir drosophila motor axon pathfind path axon travel reach target subsequ synapt connect form high stereotyp cell surfac protein csps mediat process complet understood drosophila neuromuscular junction nmj ideal system studi pathfind target specif accomplish axon trajectori innerv pattern known easili visual dpr csp requir synapt partner choic neuromuscular visual circuit axon pathfind olfactori neuron organ studi show dpr also requir motor axon pathfind uncov dpr mediat process use immunoprecipit follow mass spectrometri identifi dpr associ protein one noct unstructur intracellular protein implic circadian rhythm entrain map noct express larva found wide express neuron muscl glia cell specif knockdown suggest noct requir presynapt mediat motor axon pathfind addit found noct dpr genet interact control nmj assembl suggest function molecular pathway overal data reveal novel role dpr newli identifi interactor noct motor axon pathfind provid insight csps regul circuit assembl
|
D004330;D029721
|
T123;T116;T204
|
36,271,406
|
high co express immun checkpoint receptor pd ctla lag tim tigit tumor infiltr lymphocyt earli stage breast cancer high express immun checkpoint receptor icr tumor microenviron regul anti tumor respons studi differenti express icr tumor infiltr lymphocyt til patient earli stage breast cancer investigatedth studi includ patient underw surgeri diagnosi earli stage breast cancer septemb march til isol perform use mac tumor separ devic tumor separ kit pd ctla lag tim tigit express cytotox natur killer nk cell til peripher blood lymphocyt pbls determin flow cytometrypati high ki index high til densiti posit like increas cd cd dim nk cell til patient tumor like increas express pd lag tigit tumor infiltr cd cytotox cell tumor pd ctla tigit lag tim express cd cd cd bright nk cell til show signific posit correl pd cd tigit cd ctla cd cell pbls til found negat correl wherea tim express cd cd cd dim cell pbls til show posit correlationsour result suggest cd cd dim nk cell til may play major role immun respons posit high prolifer breast tumor patient earli stage breast cancer furthermor various icr found high co express til includ pd ctla lag tim tigit receptor may synergist suppress respons tumor may trigger immun escap mechan earli stage carcinogenesi howev icr express tim pbls found accompani counterpart til
|
D016246;D001943
|
T191;T025
|
36,271,404
|
mediat measur base care implement communiti mental health set result mix method evalu tailor implement approach tout superior standard one reason tailor approach afford opportun select strategi resolv determin local context howev result implement trial topic equivoc therefor import explor relev contextu factor function determin evalu improv tailor subsequ associ chang implement outcom ie via statist mediat better understand tailor achiev achiev effect present studi examin associ tailor standard implement approach contextu factor might mediat chang target implement outcom initi implement measur base care specif clinic integr patient health questionnair phq depress communiti mental health organ
|
D007857;D008603
|
T078;T041;T054
|
36,271,403
|
reduc global health inequ rare disord evalu intern prader willi syndrom organis echo programm peopl rare disord face signific global health inequ challeng rais awar develop nucleus expert countri abl provid guidanc other countri intern prader willi syndrom organis ipwso establish project echo aim facilit share knowledg build intern partnership reduc global health inequ particular rare genet determin neurodevelopment disord prader willi syndrom pws four differ echo programm establish follow group individu usual parent taken leadership role countri b health profession interest pws c profession care provid support children adult pws latin american echo spanish programm start evalu undertaken one year determin extent ipwso abl recruit retain individu global natur extent benefit gain session exampl individu involv programm led local benefit method includ analys routin kept process indic survey data attende one compon programm leadership echo togeth qualit analysi survey data record interview attende countri differ socio econom status
|
D011218
|
T047
|
36,271,402
|
home becam everyth space covid impact chang home environ children physic activ sit uk covid lockdown restrict children spent almost time home signific influenc physic activ pa sedentari behaviour studi aim determin chang social physic environ home children home base sit pa stand sit break result covid restrict examin associ chang home children movement behaviour
|
D000077708;D000086382
|
T033;T039;T067;T047
|
36,271,401
|
dosimetr evalu vmat helic tomotherapi techniqu compar convent volum clinic target volum base new estro acrop post mastectomi immedi implant reconstruct contour guidelin estro acrop consensus guidelin eacg recommend implant exclud clinic target volum ctvp definit post mastectomi radiat therapi implant base immedi breast reconstruct ibr purpos studi investig effect helic tomotherapi htp volumetr modul arc therapi vmatp treatment techniqu term ctvp coverag reduc organ risk oar normal tissu implant dose ctvp use treatment plan target structur instead convent ctv
|
D050397;D001943
|
T061;T191
|
36,271,400
|
associ depress happi sleep durat data uae healthi futur pilot studi unit arab emir healthi futur studi uaehf one first larg prospect cohort studi one studi region examin caus risk factor chronic diseas among nation unit arab emir uae aim studi investig eight item patient health questionnair phq screen instrument depress among uaehf pilot particip
|
D006240;D003863
|
T184;T041;T048
|
36,271,399
|
sustain deimplement continu puls oximetri monitor children hospit bronchiol studi protocol elimin monitor overus emo type iii effect deimplement cluster random trial method sustain deimplement overus medic practic ie practic support evid understudi pediatr hospit medicin continu puls oximetri monitor children common viral respiratori ill bronchiol recommend specif circumst three nation guidelin discourag use children receiv supplement oxygen guidelin discord practic ie overus remain preval hospit pilot educ outreach audit feedback result immedi reduct overus howev best strategi optim sustain deimplement success unknown
|
D010092;D001988
|
T060;T047;T059
|
36,271,397
|
contribut communiti health worker treatment common ill among year old rural uganda control malaria pneumonia diarrhoea import reduct morbid mortal among children year uganda adopt integr communiti case manag strategi use communiti health worker chws address challeng extent trend three condit manag chws well document studi done describ epidemiolog trend three common ill treat chws bugoy sub counti rural uganda
|
D011014;D008288
|
T047;T050
|
36,271,396
|
specif metabolit drive determinist assembl diseas rhizospher microbiom weaken microbi degrad autotoxin process function underli assembl rhizospher microbi communiti may strong link mainten plant health howev assembl process function chang deterior soilborn diseas remain unclear investig featur rhizospher microbiom relat fusarium wilt diseas assess assembl comparison pair diseasedhealthi sequenc data untarget metabolom employ explor potenti communiti assembl driver shotgun metagenom sequenc use reveal mechan metabolit mediat process soil condit
|
D064307;D005670
|
T001;T032;T004;T028
|
36,271,395
|
percept healthcar worker hcws toward childhood immun immun servic fiji qualit studi childhood immun global recogn singl effect strategi prevent childhood diseas mortal percept healthcar worker import behavior attitud influenc parent decis make process research aim explor factor influenc healthcar worker experi percept deliv childhood immun fiji
|
D007722;D006282
|
T053;T097
|
36,271,393
|
general control nonderepress interact cation amino acid transport affect aed aegypti fecund amino acid transport protein cation amino acid transport cat part nutrient sensor fat bodi mosquito member slc famili cation amino acid transport paramount detect elev amino acid level mosquito hemolymph blood meal subsequ chang gene express fat bodi
|
D000330
|
T204
|
36,271,392
|
moringa household water purif method communiti percept pilot studi guinea bissau public percept water relat issu still research topic current paper intend explor local communiti percept regard household water purif hwp strategi name tri new method moringa seed powder moringa teabag
|
D029587;D018508
|
T052;T002;T057
|
36,271,390
|
chang retin vascular bifurc eye myopia evalu effect myopia retin vascular bifurc
|
D009216
|
T047
|
36,271,389
|
comprehens updat cido communiti base coronavirus infecti diseas ontolog current covid pandem previous sarsmer outbreak result seri major global public health crise argu interest develop effect safe vaccin drug better understand coronavirus associ diseas mechen necessari integr larg exponenti grow bodi heterogen coronavirus data ontolog play import role standard base knowledg data represent integr share analysi accord initi develop communiti base coronavirus infecti diseas ontolog cido earli
|
D000086382;D017934;D014612;D003141
|
T129;T121;T116;T067;T005;T047
|
36,271,388
|
physic activ gestat weight gain systemat review observ studi excess weight gain pregnanc recogn lead complic pregnanc affect foetal growth limit weight gain pregnanc becom public health concern aim perform systemat review assess whether observ studi report associ physic activ pa gestat weight gain gwg particular interest whether insuffici pa might associ high gwg
|
D000078064;D011248
|
T033;T046
|
36,271,387
|
profil atm regul gene drosophila physiolog condit ioniz radiat atm ataxia telangiectasia mutat protein kinas high conserv metazoan play critic role dna damag respons oxid stress metabol stress immun rna biogenesi etc system profil atm regul gene includ protein code gene mirna long non code rnas great improv understand atm function regul result differenti express protein code gene mirna long non code rnas atm mutat fli identifi physiolog condit x ray irradi function differenti express gene atm mutat fli regardless protein code gene non code rnas close relat metabol process immun respons dna damag respons oxid stress phenomena persist irradi cross talk regul toward mirna atm ef p develop irradi knock fli knock fli irradi induc mirna sensit ioniz radiat
|
D062085;D035683
|
T123;T114
|
36,271,386
|
evalu anaplast thyroid carcinoma kurdistan region iraq anaplast thyroid carcinoma rare lethal diseas account thyroid malign aggress locoregion diseas high rate distant metastasi poor prognosi mean surviv rate month diagnosi retrospect studi aim analys clinic patholog featur atc assess treatment procedur outcom
|
D065646;D013964
|
T191
|
36,271,385
|
mental health profession awar parent function person sever mental disord retrospect chart studi proport person sever mental ill smi parent increas recent decad children parent smi increas risk medic behavior emot development academ social problem also increas risk injuri accid mortal addict various psychiatr disord compar children parent diagnos aim examin extent mental health profession mhps treat adult patient smi ambulatori set awar individu function three parent domain parent function famili support system children condit also compar psychiatrist awar psychologist social worker
|
D008603;D001523
|
T041;T048
|
36,271,384
|
higher pre treatment skin sympathet nerv activ elev rest heart rate chemoradiotherapi predict wors esophag cancer outcom chemoradiotherapi crt might affect autonom system mainstay therapi advanc esophag squamous cell carcinoma escc autonom dysfunct found possibl lead cancer mortal elev rest heart rate rhr skin sympathet nerv activ skna new method stimul electr signal skin evalu autonom function sympathet tone studi investig associ chang rhr autonom function escc mortal
|
D004938;D000077277
|
T191
|
36,271,383
|
malaria surveil case manag remot indigen communiti panama result communiti base health worker pilot panama one eight countri mesoamerica aim elimin malaria malaria concentr indigen remot region like guna yala polit autonom region access health servic limit case predomin detect intermitt activ surveil improv routin access care joint effort made guna yala author ministri health pilot network communiti health worker chws equip rapid diagnost test treatment impact pilot describ
|
D003150;D008288
|
T047;T102;T097
|
36,271,382
|
comparison femor mechan intern fixat remov effect sclerosi femor stress finit element analysi femor neck fractur common traumat injuri remov intern fixat remain controversi especi term mechan stabil moreov collaps necrosi femor head continu occur fractur heal believ sclerot cancel bone scb format around screw associ femor head necrosi aim compar mechan featur implant remov determin effect scb format stress distribut
|
D005265
|
T037
|
36,271,381
|
overlap syndrom year old girl system lupus erythematosus anti oj antibodi posit polymyos case report peculiar present overlap syndrom children make precis diagnosi difficult children overlap syndrom may may specif antibodi present case year old girl diagnos overlap syndrom system lupus erythematosus sle juvenil polymyos jpm test posit anti oj antibodi
|
D008180;D017285;D009220;D003524
|
T129;T047;T121
|
36,271,380
|
persuas coercion empir ethic analysi use influenc strategi mental health communiti care influenc strategi persuas interperson leverag use mental health care influenc patient behaviour improv treatment adher one ethic concern use strategi may constitut coerciv behaviour inform coercion negat impact patient satisfact qualiti care howev influenc strategi may affect patient percept umbrella definit inform coercion may unsatisfactori furthermor previous research indic profession also perceiv disson theoret explan inform coercion behaviour clinic practic studi analys mental health profession mhps view perceiv ethic implic influenc strategi communiti care
|
D001523;D008605
|
T058;T048
|
36,271,379
|
efficaci car immunotherapi met overexpress tumor elig anti met target therapi aberr activ met receptor cancer sustain genet alter frequent transcript upregul fraction met amplifi mutat tumor sensibl met target agent respons typic short last secondari resist eventu occur sinc absenc genet alter met usual tumor driver met overexpress tumor notpoor respons met target therapi consequ vast major tumor exhibit met activ still repres unmet medic need
|
D000076962
|
T129;T116;T192
|
36,271,378
|
hotspot determin women discriminatori attitud toward peopl live hiv evid ethiopian demograph health survey data human immunodefici virus hiv major public health concern ethiopia profound effect women discriminatori attitud toward peopl live hiv plwh impos signific impact patient outcom relat issu henc studi aim investig hotspot area determin factor women discriminatori attitud toward peopl live hiv
|
D015658
|
T047
|
36,271,377
|
exosom like nanovesicl deriv phellinus linteus inhibit mical express cross kingdom regul inhibit ultraviolet induc skin age phellinus linteus pl typic medicin fungus shown antitumor anti inflammatori activ howev studi effect anti photoag limit studi shown exosom like nanovesicl function compon mani medicin plant mirna exosom like nanovesicl play cross kingdom regulatori role present research fungi exosom like nanovesicl felnv
|
D015595;D055354;D035683
|
T026;T123;T042;T033;T114
|
36,271,376
|
age combin gender valuabl paramet differenti diagnosi solid pseudopapillari tumor pancreat neuroendocrin neoplasm clinicopatholog characterist solid pseudopapillari tumor spt pancreat neuroendocrin neoplasm pnen differ therefor systemat investig perform clinicopatholog characterist distinguish spt pnen
|
D018358;D010190
|
T191
|
36,271,375
|
endometri compact human chorion gonadotrophin administr reduc ectop pregnanc rate follow fresh embryo transfer vitro fertilizationintracytoplasm sperm inject cycl patient non thin endometrium retrospect cohort studi studi aim studi whether chang endometri thick day human chorion gonadotrophin hcg administr day embryo transfer et effect ectop pregnanc ep rate follow fresh vitro fertilizationintracytoplasm sperm inject ivficsi cycl
|
D020554;D011271
|
T061;T046
|
36,271,374
|
efficaci safeti combin target therapi immunotherapi versus target monotherapi unresect hepatocellular carcinoma systemat review meta analysi cancer therapi evolv non specif cytotox agent select mechan base approach includ target agent immunotherapi although respons target therapi unresect hepatocellular carcinoma hcc accept improv surviv high tumor recurr rate drug relat side effect continu problemat given immun checkpoint inhibitor alon robust enough improv surviv unresect hcc grow evid support combin target therapi immunotherapi synergist effect
|
D006528;D008113
|
T191
|
36,271,373
|
genom characterist two breast malign phyllod tumor pregnanc lactat identifi whole exom sequenc genom landscap breast malign phyllod tumor pts well defin especi pregnanc relat malign pts clarifi topic whole exom next generat sequenc ngs perform tumor sampl pair normal breast tissu two pregnanc relat malign pts follow function analysi genet alter
|
D003557;D001943
|
T191
|
36,271,372
|
influenc optic zone myopic correct small incis lenticul extract short term studi evalu influenc preoper optic zone myopic correct small incis lenticul extract
|
D009216;D001251
|
T047
|
36,271,371
|
us medic organ climat chang advocaci review public face websit climat chang pose risk health catastroph must expediti address across health care sector physician consid trustworthi well posit discuss climat chang patient unifi strategi us medic societi essenti effect mitig carbon footprint address health concern
|
D057231
|
T070
|
36,271,370
|
conduct nation burden diseas studi knowledg translat eight small european state challeng opportun sever countri across europ engag burden diseas bod studi articl aim understand experi eight small european state relat research opportun challeng conduct nation bod studi knowledg translat research output polici make
|
D000090963;D011050
|
T062;T064;T091;T057
|
36,271,369
|
spotitpi semi autom tool object base co local fluoresc label microscopi imag fluoresc microscopi co local refer spatial overlap differ fluoresc label cell degre overlap two channel microscop may reveal physic interact topolog function interconnect molecul recent advanc imag field requir develop special comput analysi softwar unbias assess fluoresc label microscopi imag
|
D007091;D012984
|
T090;T170;T073;T066
|
36,271,368
|
differ rest fmri cognit function drug nave bipolar disord schizophrenia bipolar disord bd schizophrenia sc mani similar clinic manifest acut phase bd psychot symptom sc also emot symptom onset suggest uncertainti distinguish bd sc clinic symptom
|
D001714;D012559
|
T048
|
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