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biomedical-topic-categorization-validation

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36,269,213
dearomat cyclic diphenylhydrazin har semidin rearrang synthesi spirocycl tetrahydroquinolin synthesi novel tetrahydroquinolin contain spirocycl achiev acid promot dearomat cyclic diarylhydrazin reaction proceed dearom semidin rearrang furnish stabl yet reactiv spirocyclohexadieniminium ion use electrophil dien one pot sequenc transform effici produc novel diazaspirocycl allow synthet elabor cyclohexadienamin product
D011804
T109
36,269,203
tuberculosi preval incid prevent south african cohort children live hiv describ tuberculosi tb diseas among antiretrovir treatment art elig children live hiv clhiv south africa highlight tb prevent opportun
D015658;D014376;D044342
T047
36,269,195
tandem reduct ammonolysi condens deamin reaction synthesi benzothiadiazin phenylsulfonyl h benzimidazol novel rout sncl promot tandem reduct ammonolysi condens deamin reaction use nitril nitro n phenylbenzenesulfonamid n nitrophenyl benzenesulfonamid synthes deriv benzothiadiazin phenylsulfonyl h benzimidazol develop method featur conveni oper good function group toler addit employ unsensit inexpens sncl proh reaction reagent provid direct approach synthesi pharmaceut import target
D001581;D001562
T109
36,269,192
continu posit airway pressur cpap sever pneumonia low middl incom countri systemat review contextu factor continu posit airway pressur cpap may role reduc high mortal children less year world health organ sever pneumonia evid need understand import contextu factor impact implement effect safeti low resourc set
D011014;D001988
T047;T050
36,269,191
effect perceptu histori interpret causal abil interpret spatiotempor conting term causal relationship play key role human understand extern world inde detect simpl properti enabl us attribut causal attribut interact object investig degre percept causal depend recent experi found low level properti visual stimuli particip shown launch sequenc collid circl vari collis lag ask report impress causal found short term attract long term repuls attract effect perceptu histori interpret causal stimuli direct follow causal impress like judg causal vice versa howev prior judgment less recent trial bias current percept positiveattract negativerepuls influenc interpret result term two potenti mechan adapt tempor bind window updat intern represent causal overal result demonstr import role prior experi even causal fundament build block understand world
D007600
T041
36,269,186
quantit microstructur analysi cellular tissu remodel human glaucoma optic nerv head measur quantit chang lamina cribrosa lc cell connect tissu structur human glaucoma eye
D005901;D005902;D009898
T033;T047;T023
36,269,185
microrna p regul retin angiogenesi target sgk vascular endotheli cell purpos studi investig effect mechan microrna mir p retin angiogenesi vitro vivo
D035683;D009389;D017346;D012160
T123;T116;T126;T114;T023;T046
36,269,184
efficaci comparison repeat low level red light low dose atropin myopia control random control trial compar treatment efficaci repeat low level red light rlrl therapi atropin eye drop myopia control
D001285;D009216
T121;T047;T109
36,269,183
feasibl magnet levat prosthesi frame custom use craniofaci scan print determin feasibl custom frame generat approach nonsurg manag sever blepharoptosi magnet levat prosthesi mlp
D001763;D001186
T047;T074
36,269,172
apcccdc mediat degrad clb prompt astral microtubul stabil anaphas onset key accur chromosom partit offspr abil mitot spindl microtubul respond differ molecular signal remodel dynam accord spindl microtubul convent divid three class kinetochor interpolar astral microtubul kmts imt amt respect among amt regul remain elus show amt dynam tight regul amt remain unstabl metaphas stabil anaphas onset switch amt dynam import proper spindl orient specif requir degrad mitot cyclin clb anaphas promot complex bound activ subunit cdc apcccdc data highlight uniqu role mitot cyclin clb control amt regul factor kip prime candid provid framework understand amt regul vertebr uncov mechanist principl apcccdc choreograph time late mitot event sequenti impact three class spindl microtubul
D000705;D008870;D008941;D064199
T026;T123;T116;T043
36,269,165
resid time molecular dynam simul work effici method propos calcul molecular dynam trajectori resid time rts relat quantiti one design obtain rt distribut mean resid time mrts residu time distribut mean residu time comput method requir assumpt approxim made common use method link popular method literatur identifi shown much faster new method use replac latter advantag also prescript estim uncertainti mrts obtain though propos method provid anoth even faster method calcul mrts uncertainti mean residu time also propos yield exact result first one allow obtain mention distribut anoth popular method base autocorrel function comput mrts analyz term assumpt approxim altern also base autocorrel function faster requir fewer assumpt present prescript calcul uncertainti mrts obtain latter method also provid literatur method discard short transient escap algorithm suggest much faster use one allow integr treatment process also wide applic preprocess step use conjunct propos method mention main disadvantag two approach discard brief escap maximum durat allow escap consid transient appear paramet determin particular system studi altern paramet free method similar charact also propos estim mean resid time particl reach constant probabl leav region interest
D056004;D000465
T066;T170;T044
36,269,164
applic fundament chemic principl solvat effect unifi perspect interact pattern solut demonstr util basic chemic principl like big good dmb rule studi solvat interact distinct solut ion solvent correspond approach allow us defin relev criteria maximum solvat energi ion pair differ solvent term electroneg chemic hard find reveal dmb principl culmin strong weak acid base concept recent deriv specif ion effect various solvent applic dmb approach highlight similar condit chemic hard reminisc hardsoft acid base principl compar conclus also drawn regard chang solvent show favor solvent interact main driven low chemic hard well high electroneg differ ion solvent find highlight solvat interact govern basic chemic principl demonstr close similar solvat mechan chemic reaction
D013816
T090
36,269,162
artifici tactil recognit enabl flexibl low voltag organ transistor low power synapt electron advanc self power intellig strain system human comput interact crucial toward wearabl energi save applic simultan lower oper voltag thus reduc power consumpt particular interest brain like smart synapt hardwar system consid promis candid low power parallel comput learn process howev combin low voltag organ transistor energi effici smart synaps hardwar system driven tactil signal hinder limit materi technolog employ elastomer copolym poli vinyliden fluorid co hexafluoropropylen pvdf hfp high hfp content mol flexibl low voltag transistor v g v low energi consumpt synaps j devis simultan along lowest qualiti factor r p w v g j v furthermor base low voltag low power consumpt characterist flexibl artifici tactil recognit system mors code recognit establish without comput support mechan flexibl cycl stabil imag contrast enhanc function simul pattern recognit accuraci multilay perceptron neural network also simul work recommend rout exploit low voltag low power consumpt synapt system smart human machin interfac low energi loss base flexibl organ synapt transistor
D004581;D014110
T090;T042
36,269,159
superfici femor arteri endovascular therapi month primari patenc rate contemporari endovascular devic patient approxim million peopl experi peripher arteri diseas pad unit state today superfici femor arteri sfa diseas common caus symptomat pad new generat nitinol stent drug coat stent drug coat balloon dcb cover stent direct orbit atherectomi devic shown promis result howev clinic equipois persist regard optim select devic larg attribut differ inclus criteria studi popul length lesion treat definit patenc restenosi follow method date pivot trial
D058729;D000800
T061;T047
36,269,158
comparison acur neo vs neo transcathet heart valv data exist immedi outcom next generat acur neo prosthesi boston scientif distinguish activ seal mechan sought determin procedur outcom transfemor transcathet aortic valv replac use neo comparison predecessor acur neo
D001024;D006350;D065467
T061;T047;T074
36,269,154
f fdg petct evalu therapi respons hormon receptor posit bone domin metastat breast cancer fluorin f fluorodeoxyglucos fdg petct shown promis use assess treatment respons patient bone bone domin bd metastat breast cancer mbc singl institut prospect singl arm studi women median age year rang year biopsi proven estrogen receptor posit bone bd mbc begin new endocrin therapi octob august valu earli week f fdg petct predict progress free surviv pfs evalu f fdg petct perform baselin week week maximum standard uptak valu suv max peak suv suv peak measur five index lesion primari end point pfs secondari end point overal surviv os time skelet relat event tsres end point compar respond reduct sum suv max target lesion nonrespond week week percentag chang baselin suv max week f fdg petct high correl r week time point pet respond numer longer pfs month vs month p os month vs month p tsre month vs month p compar nonrespond suggest clinic util week f fdg petct earli predictor treatment failur keyword breast cancer metastat breast cancer bone domin metastat breast cancer fdg petct estrogen receptor posit metastat breast cancer supplement materi avail articl clinic trial registr nct rsna
D001859;D001943
T191
36,269,144
quatern acridin maleimid maldi probe enabl mass spectrometri imag thiol thiol essenti metabolit associ redox imbal metabol disord diseas matrix assist laser desorptionion mass spectrometri imag maldi msi facilit imag metabolit tissu imag thiol remain challeng develop method visual thiol use stabl isotop label sil maldi probe mixtur unlabel deuterium label reagent provid adduct signal identifi endogen thiol tissu seri maldi probe candid ration design structur effect relationship determin first reactiv differ warhead toward thiol group evalu maleimid best situ derivat second acridin fragment show best improv ms respons third perman charg introduc detect improv posit mode final hydrogen methyl group replac deuterium atom obtain novel sil maldi probe thus facilit signific annot thiol final obtain dioxo dihydro h pyrrol yl ethyl carbamoyl methylacridin ium iodid mai mada enabl direct msi thiol fine structur human liver tumor without reduct procedur work built sil maldi probe first time provid strategi ration design maldi probe
D013438;D000166
T109
36,269,138
sar cov seropreval studi first wave among person live work overcrowd swiss prison prison epicentr infecti diseas howev empir evid impact sever acut respiratori syndrom coronavirus sar cov pandem prison still scarc studi aim estim seropreval rate anti sar cov largest crowd swiss prison compar seropreval rate general popul
D000086402;D000086382
T005;T067;T047
36,269,126
augmin prevent merotel attach promot proper arrang bridg kinetochor fiber human mitot spindl made microtubul nucleat centrosom kinetochor pre exist microtubul augmin complex howev unknown augmin mediat nucleat affect distinct microtubul class therebi mitot fidel use superresolut microscopi analyz previous indistinguish microtubul arrang within crowd metaphas plate area demonstr augmin vital format uniform arrang parallel unit consist sister kinetochor fiber connect bridg fiber order geometri help prevent resolv merotel attach wherea augmin nucleat bridg fiber prevent merotel attach creat near parallel high bundl microtubul arrang unfavor creat addit attach augmin nucleat k fiber produc robust forc requir resolv error anaphas sted microscopi reveal bridg fiber impair twice much k fiber follow augmin deplet complet absenc bridg fiber signific portion kinetochor pair especi inner part spindl result specif reduct interkinetochor distanc taken togeth propos model augmin promot mitot fidel generat assembl consist bridg kinetochor fiber align sister kinetochor face opposit pole therebi prevent erron attach
D018386;D008941
T026
36,269,125
system corticosteroid radicular non radicular low back pain corticosteroid medic anti inflammatori immunosuppress properti system corticosteroid administ oral intraven intramuscular rout use treat various type low back pain includ radicular back pain due spinal stenosi non radicular back pain spinal stenosi howev uncertainti benefit harm system corticosteroid low back pain
D006943;D017116;D013130
T033;T184;T047;T020
36,269,124
incarcer menstruat covid viewpoint exacerb inequ health dispar south african correct facil menstrual health menstrual hygien manag mhm incarcer women remain relat low agenda public health intervent global widen inequit access incarcer women safe readili avail menstrual health product mhp covid pandem advers impact mhm gain made various develop sector global north south amplif vulner alreadi risk popul especi signific develop countri south africa incarcer femal popul often forgotten minor
D008598;D000086382
T047;T040;T067
36,269,122
model electrostat interact catalyt activ nife hydrogenas planar electrod hydrogenas group enzym caught interest research renew energi due abil catalyz redox reaction hydrogen exploit hydrogenas electrochem devic requir immobil surfac suitabl electrod graphit orient enzym electrod import ensur good flux electron catalyt center array iron sulfur cluster present comput approach determin possibl orient nife hydrogenas pdb ed planar electrod function ph salin electrod potenti calcul base solut linear poisson boltzmann equat use pygb softwar result reveal electrostat interact truli immobil enzym surfac electrod instead dynam equilibrium differ orient nonetheless averag thermal access orient find signific differ relat solut salin ph effect electrod potenti relat weak also combin model protein adsopt desorpt equilibria electron transfer protein electrod arriv predict electrod activ function enzym concentr
D006864
T126;T116
36,269,121
total synthesi aflastatin total synthes aflastatin c c degrad fragment r h accomplish synthes featur sever complex diastereoselect fragment coupl includ felkin select trityl catalyz mukaiyama aldol reaction chelat control aldol reaction involv soft enol magnesium anti felkin select boron mediat oxygen aldol reaction care comparison spectroscop data synthet c c degrad fragment report isol group reveal structur misassign lactol region natur deriv degrad product ultim data report natur deriv aflastatin c c degrad lactol r h attribut deriv lactol trideuteriomethyl ether c r cd addit revis absolut configur six stereogen center c c c c confirm
D011760;D000447
T109
36,269,107
identif biochem character pyrrolidinedion novel inhibitor bacteri enzym mura develop novel antibiot target earli step cell wall peptidoglycan biosynthesi seem promis strategi still underutil mura first enzym pathway target clinic use irrevers inhibitor fosfomycin howev mutat bind site caus bacteri resist herein report seri novel revers pyrrolidinedion base mura inhibitor equal inhibit wild type wt mura fosfomycin resist mura cd mutant show addit effect fosfomycin inhibit wt mura potent inhibitor ic mode inhibit analyz use nativ mass spectrometri protein nmr spectroscopi compound class nontox human cell high stabl human fraction human plasma bacteri cell lysat taken togeth novel compound class might develop toward antibiot drug candid inhibit cell wall synthesi
D005578;D019883
T116;T195;T126;T109
36,269,101
fluoresc activ absorpt shift tag advanc imag biosens conspectusfluoresc label biosensor play central role biolog medic research target specif biomolecul cell allow noninvas imag machineri govern cell organ real time recent chemogenet report made organ dye specif anchor genet tag challeng paradigm fulli genet encod fluoresc protein combin advantag synthet fluorophor target select genet encod tag chemogenet report open new excit prospect studi cell biochemistri biolog account present grow toolbox fluoresc activ absorpt shift tag fast small monomer protein kda amino acid residu use marker monitor gene express protein local live cell organ engin direct protein evolut photoact yellow protein pyp bacterium halorhodospira halophila prototyp fast bind stabil fluoresc state live cell compat hydroxybenzyliden rhodanin chromophor class chromophor normal dark free solut cell dissip light energi nonradi process protein caviti fast allow stabil deproton state chromophor block chromophor planar conform lead high fluoresc protein chromophor assembl use fluorogen dye also call fluorogen enabl imag fast fusion protein cell high contrast without need remov unbound ligand separ wash step fluorogen various spectral properti exist nowaday allow investig adjust spectral properti fast experiment condit molecular engin allow furthermor generat membran imperm fluorogen select label cell surfac protein year generat collect fast variant expand spectral properti fluorogen select use concert strategi involv molecular engin direct protein evolut moreov protein engin allow us adapt fast design fluoresc biosensor circular permut enabl generat fast variant increas conform flexibl design biosensor fluorogen bind condit recognit given analyt bisect fast two complementari fragment allow us furthermor creat split variant revers complement allow detect imag dynam protein protein interact provid general overview current state develop differ system applic advanc live cell imag biosens discuss potenti futur direct
D015374;D012236
T130;T059;T075;T109
36,269,100
cutan leishmaniasi iran review epidemiolog aspect emphasi molecular find leishmania parasit caus zoonot cutan leishmaniasi cl circul human rodent sandfli iran studi publish data collect scientif sourc web scienc scopus pubm springer researchg wiley onlin ovid ebsco cochran librari googl scholar sid keyword search articl these abstract cutan leishmaniasi epidemiolog reservoir vector climat factor identif iran review reveal cl preval west iran center south iran also involv recent year lack facil suburban region aggrav factor human communiti part southern iran promin foci cl due presenc potenti rodent host region rhombomi opimus merion lybicus tatera indica well document speci host leishmania speci iran moreov r opimus found coinfect leishmania major l turanica northeast center iran mashhad kerman yazd sometim shiraz tehran foci distinct area l tropica molecular identif use genom diagnosi kdna fragment parasit indic heterogen leishmaniasi differ part countri although cutan leishmaniasi predica health system relat control iran
D016773;D018320
T047;T204
36,269,089
aqueous amin toler photocycloaddit unactiv olefin kochi salomon reaction photochem cycloaddit capabl combin two electron unactiv olefin cyclobutan yet reaction remain larg unexplor suffer mani drawback notabl intoler lewisbrnst basic amin amid sinc group ubiquit biolog activ pharmaceut amin toler kochi salomon reaction would great facilit rapid explor novel drug scaffold herein disclos transform run water wide avail cu ii salt miner acid furthermor appli methodolog synthes varieti amin contain cyclobutan includ known novel pharmacolog analogu
D000475;D003503
T109
36,269,085
model studi dynam kinesin molecular motor kinesin constitut subfamili larg superfamili adenosin triphosph depend microtubul base motor protein kinesin motor domain c termin end peptid play key role spindl assembl mainten nonprocess motor wherea other move process microtubul take bud yeast cik kar human hset exampl studi theoret dynam process kinesin motor move singl microtubul load dynam motor coupl ndc protein move singl microtubul dynam motor move microtubul array dynam nonprocess drosophila ncd motor also discuss studi explain well avail experiment data moreov provid predict result show process kinesin motor move effici microtubul array toward minus end reach minus end stay stabli thus perform function organ microtubul bipolar spindl polar array spindl pole
D016547;D029701
T123;T126;T116
36,269,076
plant latex versatil sustain emulsifi emuls class high surfac energi materi typic stabil surfact polym particl combin consider effort develop new emulsifi exploit develop synthet chemistri howev synthet surfac activ speci may assist stabil specif type immisc liquid liquid system one stabil provid solut interfac stabil problem moreov synthesi surfac activ system involv high product cost complex synthesi rout generat substanti amount chemic wast work show plant latex aqueous dispers colloid scale particl small well larg bioactiv speci also present use versatil sustain sourc interfac stabil constitu latex found reduc oil water interfaci tension due spontan adsorpt surfac activ speci present latex surfac activ natur latex exploit obtain stabl singl emuls doubl emuls des multipl emuls mes result conclus show plan latex potenti versatil sourc stabil emuls creat consid differ type immisc liquid system
D007840;D045703
T122;T167;T109
36,269,075
bio macromolecular design roadmap toward tough bioadhes emerg sutureless wound closur techniqu led paradigm shift wound manag state art biomateri offer biocompat biodegrad platform enabl high cohes tough adhes rapid bleed control well robust attach implant devic tough bioadhes stem synergist contribut cohes adhes interact review provid biomacromolecular design roadmap develop tough adhes surgic sealant discuss librari materi method introduc tough adhes biomateri intrins tough elast polym leverag primarili introduc strong dynam inter intramolecular interact either polym chain design use crosslink regul addit addit mani effort made promot underwat adhes via covalentnoncoval bond micromacro interlock mechan tissu interfac materi set function addit purpos relat character method review measur report need fair comparison differ materi properti discuss final futur direct research opportun develop tough bioadhes surgic sealant highlight
D014014
T122
36,269,062
target dna activ proxim local catalyt hairpin assembl enabl form split dna ag nanoclust robust sensit fluoresc biosens proxim local catalyt hairpin assembl pl cha intrigu rapid sensit assay hiv specif dna segment use templat integr green ag nanoclust ig agnc emitt herein report first design activ pl cha circuit confin three way junction architectur wja fluoresc sens end recogniz complement program stem loop hairpin h two split templat sequenc ig agnc separ overhung contigu pair stem h anoth hairpin h hybrid among h h two singl strand linker l l allow stabl construct wja upon present input wja local pl cha oper toehold mediat strand displac h h reactant ration displac repeat recycl analog specif catalyst induc hairpin assembl event result hybrid product enabl collect combin two split parent scaffold host ig agnc output depend fluoresc respons wja structur confin spatial proxim two reactiv hairpin yield high local concentr manipul pl cha oper achiev rapid reaction kinet via catalyz recycl typic catalyt hairpin assembl cha simpl assay strategi would open arena develop various pl cha base circuit capabl modul fluoresc emiss ig agnc applic biosens bioanalysi
D015374
T059;T075
36,269,060
hierarch porous metal organ gel deriv materi fundament potenti applic metal organ gel mog emerg novel class function soft materi scaffold framework fabric metal ligand coordin combin supramolecular interact exampl hydrogen bond stack combin organ inorgan metalmet oxo cluster build block signific step forward made develop new electrochem sensor superhydrophob materi ion storag devic among other leap forward extend induc intrins hierarch microporousmesopor pore structur metal organ materi within review give overview recent develop grow field first shed light onto parallel well establish field convent gel outlin similar differ afterward classifi differ type mog accord architecturalstructur natur pristin mog hybrid mog crosslink base mog mog deriv materi furthermor look differ properti mog requir prepar spatial pattern macro structur mog emerg addit manufactur technolog moreov differ potenti field applic mog mog deriv materi critic evalu potenti improv pitfal comparison tradit gel base materi given final comprehens outlook futur direct develop mog provid
D008670
T197
36,269,052
preval sleep disord among first respond medic emerg meta analysi shift work irregular work schedul among first respond associ physic psycholog problem sleep disord conduct first meta analysi explor estim preval sleep disord among first respond medic emerg
D007319;D006970;D012893;D020181;D060731;D005764;D002318
T184;T033;T097;T047;T048
36,269,051
diphenylalanin deposit dip coat acid solut fiber close homogen film simpl precis control strategi molecular assembl enabl construct biomateri alway develop dip coat deposit diphenylalanin ff onto planar solid substrat aqueous acid acet propano formic hcl solut studi function process control paramet deposit speed initi concentr ff acid extern gas flow result studi optic microscopi afm ellipsometri low acid low ff concentr ff form microfib nanofib stripe fiber aggreg higher acid ff concentr close film ff remark smooth surfac found thick film well control ff concentr deposit speed explain evapor regim unusu result provid new possibl fabric abund structur simpl strategi develop candid biolog membran area
D004151;D057139
T116;T073
36,269,047
thermal nocicept ionic skin trpv ion channel inspir heat activ dynam ionic liquid artifici reproduct tactil sensori function natur skin crucial intellig sens human comput interact medic health thermal nocicept essenti human tactil function avoid noxious thermal stimuli depend specif heat activ trpv ion channel inspir trpv dynam ionic liquid heat activ characterist design prepar activ c near physiolog noxious temperatur accompani steep rise electr respons signal electr behavior deem extrem version temperatur sensat similar natur thermal nociceptor heat activ mechan confirm feasibl strategi regul thermal respons behavior ion report dynam ionic liquid unpreced intrins temperatur respons sensit c consider similar heat activ dynam ionic liquid trpv ion channel term heat activ characterist electr output signal ultratherm sensit liquid ionic skin abil thermal nocicept fabric show consider potenti assist patient tactil desensit avoid noxious thermal stimuli
D006358;D052578
T120;T070;T103
36,269,044
inhibitori circuit central amygdala zona incerta drive pain relat behavior mice central amygdala neuron express protein kinas c delta cea pkc sensit follow nerv injuri promot pain relat respons mice neural circuit under modul pain relat behavior cea pkc neuron howev remain unknown studi identifi neural circuit origin cea pkc neuron termin ventral region zona incerta zi subthalam structur previous link pain process behavior experi show chemogenet inhibit gabaerg zi neuron induc bilater hypersensit uninjur mice contralater hypersensit nerv injuri contrast chemogenet activ gabaerg zi neuron revers nerv injuri induc hypersensit optogenet manipul cea pkc axon termin zi show inhibit pathway reduc nerv injuri induc hypersensit wherea activ pathway produc hypersensit uninjur paw altogeth result identifi novel nocicept inhibitori effer pathway cea pkc neuron zi bidirect modul pain relat behavior mice
D065820;D066274
T023
36,269,040
amelior neurogenesi deficit dentat gyrus may under pronounc antidepress effect trek potassium channel blockad rat depress like behavior depress consid common mental disord probe sever studi chronic mild stress contribut depress fortun antidepress amelior depress like behavior accompani revers hippocamp neurogenesi defect present studi confirm differ antidepress repair stress induc neuron behavior deficit modul adult hippocamp neurogenesi antidepress treatment restor adult hippocamp neurodegener impair chronic unpredict mild stress display decreas prolifer neuron differenti increas apoptosi newli form neuron dentat gyrus notabl sucros prefer ratio signific correl neuron differenti proport newborn apoptosi proport suggest mechanist relationship neurogenesi behavior inde neotyp trek potassium channel blocker express earlier pronounc antidepress manifest compar tradit select serotonin reuptak inhibitor fluoxetin therefor conclud administr trek potassium channel antagon revers depress deficit caus chronic stress quick via regul adult hippocamp neurogenesi
D000928;D055495
T121;T040
36,269,035
ketoglutar restor intestin barrier function promot intestin stem cell mediat epitheli regener coliti studi investig prevent effect ketoglutar kg form sodium salt citrobact rodentium cr induc coliti explor potenti mechan result demonstr cr caus bodi weight loss colon length shorten abrog kg administr colon length mice kg plus cr group signific higher mice cr group mean sd vs p benefici effect associ regul endoplasm reticulum er stress signal addit small intestin organoid generat intestin crypt mice expos kg presenc tnf iwr assess stem cell activ vitro result demonstr tnf exposur decreas viabil organoid impair barrier function suppress wnt signal abolish kg interest protect effect kg intestin barrier function abrog inhibitor wnt signal intestin organoid taken togeth kg restor barrier function regul er stress activ wnt catenin medic intestin stem cell prolifer differenti
D007656;D003092
T123;T047;T121;T109
36,269,019
dopachrom tautomeras cardiovascular inflammatori diseas new kid block anoth mif macrophag migrat inhibitori factor mif well recent describ structur homolog dopachrom tautomeras dt also term mif atyp cytokin chemokin key role host immun also import pathogen role acut chronic inflammatori condit cardiovascular diseas lung diseas adipos tissu inflamm cancer although mechanist understand mif relat limit compar extens bodi evid avail mif emerg data suggest mif function phenocopi mif may differenti even opposit activ depend diseas context review summar discuss similar differ mif mif focus structur receptor signal pathway role diseas main cover role mif homolog cardiovascular inflammatori autoimmun metabol diseas also discuss involv cancer sepsi chronic obstruct lung diseas copd particular emphasi laid upon potenti mechanist explan synergist cooper activ mif homolog cancer myocardi diseas copd oppos emerg dispar antagonist activ adipos tissu inflamm metabol diseas atherosclerosi last discuss potenti futur opportun joint target mif mif certain diseas wherea precis target one homolog might prefer condit togeth articl provid updat mechan futur therapeut avenu human mif protein focus emerg surpris dispar activ suggest mif display varieti activ distinct mif
D007249;D019746;D002318
T047;T046;T126;T116
36,268,999
anion amino cope rearrang cascad synthesi substitut benzoat ester acycl build block report new anion cascad assembl substitut benzoat ester one pot racem fluoro substitut conjug tert butylsulfinyl imin substitut methyl buteno dienol format trigger mannich addit follow amino cope like rearrang result immedi elimin fluorid lithiat enamin newli form dien intermedi contain high acid proton spontan deproton lead facil intramolecular cyclize follow sulfinamid group elimin aromat
D004952;D001565
T121;T109
36,268,993
regul mitot chromosom fold machin last sever year enorm progress made identifi molecular machin includ condensin topoisomeras fold mitot chromosom discoveri condensin generat chromatin loop loop extrus revolution energ field chromosom fold understand machin fold chromosom appropri dimens disentangl sister chromatid need determin regul deploy outlin current understand machin factor regul cell cycl depend express chromatin local activ inactiv post translat modif associ factor chromatin templat still mani open question condensin topoisomeras regul given pace progress chromosom fold field seem like mani answer year ahead
D002842;D002843
T026;T116
36,268,969
total synthesi structur revis epoxyisodaucan natur sesquiterpen use anion electrocycl reaction new synthet strategi form seven member carbocycl use anion electrocycl reaction facilit first total synthesi epoxyisodaucan natur sesquiterpen yield step longest linear sequenc misassign propos stereochemistri correct synthesi propos structur c epim addit fuse ring system concis construct tandem decyanationf member ring format epoxynitril
D012717
T109
36,268,967
colombian adapt self compass scale scs self compass crucial assess peopl relat suffer moment person difficulti object studi check psychometr properti self compass scale scs colombian sampl
D004645;D000087342
T055;T041;T054
36,268,966
spanish valid short mood feel questionnair smfq children age short mood feel questionnair smfq one well establish avail measur design assess childhood depress object present studi assess psychometr properti explor differenti item function dif smfq communiti sampl spanish children gender age differ smfq score also analyz
D000339;D004644
T041
36,268,965
drive offenc emot regul psychometr analysi emot regul questionnair erq littl known role emot regul drive studi analyz psychometr properti one common use test evalu emot regul driver sampl
D000080103
T041
36,268,964
develop valid serr scale detect extrem religi radic line grow religi polit social violenc around world studi evalu psychometr properti new scale detect extrem religi radic serr self report measur extrem religi radic
D007514
T078;T098
36,268,963
nonsuicid self injuri thought behavior adolesc valid sitbi nssi lack knowledg nonsuicid self injuri nssi spanish adolesc especi nssi thought may due pauciti nssi assess instrument valid evid sampl aim studi assess nssi thought behavior addit studi examin associ various nssi featur suicid behavior includ preliminari valid new self injuri thought behavior interview non suicid self injuri sitbi nssi
D016728;D000294
T055
36,268,962
develop valid brief version european bulli cyberbulli intervent project questionnair ebip q ecip q order prevent school bulli cyberbulli brief measur instrument adequ psychometr properti requir object studi develop combin reduc version european bulli intervent project questionnair ebip q european cyberbulli intervent project questionnair ecip q use screen bulli relat behavior school
D000077224;D058445;D019548
T068;T098;T054;T048
36,268,961
develop revis version statist anxieti scale statist anxieti common problem student take statist cours social scienc wide measur statist anxieti scale various adapt instrument shown certain problem replic factori structur system control possibl respons bias effect object studi propos short test measur statist anxieti also includ scale control social desir bias
D001008;D001007
T184;T041;T048
36,268,960
depress suicid risk mild cognit impair role alzheim diseas biomark patient depress mild cognit impair mci greater risk develop dementia depress involv higher risk suicid ideat si suicid attempt sa biomark alzheim diseas ad could help clarifi role depress si ad
D000544;D060825;D013405
T033;T047;T048
36,268,959
educ prevent antisoci delinqu behavior brazilian adolesc antisoci crimin behavior frequent associ illeg behavior commit adolesc studi aim examin antisoci crimin behavior adolesc establish guidelin contribut educ prevent specif sought evalu self report antisoci crimin behavior adolesc verifi differ variabl sex age
D000987;D057237
T055;T098;T048
36,268,958
bulli accord gender immigr background spanish student boy frequent aggressor girl conclus find gender differ victim relationship immigr background bulli differ generat still debat therefor object studi analyz victim accord gender immigr background first second generat compar attitud student bulli base variabl
D058445;D019548
T068;T098;T048
36,268,957
impact differ form coach structur inventori maling symtomatolog sim psychometr symptom valid instrument svts vulner coach negat affect perform aim assess impact differ type coach may sensit structur inventori maling symptomatolog sim
D000071252
T065
36,268,956
problemat internet use depress symptomatolog suicid ideat univers student covid confin aim estim rate piu spanish univers student lockdown take sex age account analyz relationship depress suicid ideat
D059020;D000086382
T033;T047;T067
36,268,955
person famili childhood predictor function outcom adolesc autism spectrum disord transit adolesc challeng children autism spectrum disord asd present studi explor child famili variabl predict function outcom adolesc asd emotionalbehavior difficulti social daili live skill transit secondari educ
D000067877
T048
36,268,954
telepsycholog mobil applic spanish android market use android mobil applic aim address user psycholog health increas howev review conduct public android commerci telepsycholog applic spain
D063731;D001523
T170;T048
36,268,953
interpret bias social scenario social anxieti role safeti behavior interpret bias ib safeti behavior sb mainten mechan social anxieti sa howev studi examin role ib sb togeth explain sa object studi determin whether sb explain associ ib sa evalu variabl adolesc interpret belief questionnair aibq social phobia safeti behavior scale spsbs need adapt spanish adolesc young peopl
D005239;D000072861
T041;T048
36,268,948
function structur aspect periodont furcat treatment novel approach outcom treatment furcat defect often unsatisfactori reason morpholog patholog peculiar well extens chang shape caus resect treatment periodont lesion multi root teeth therefor augment strategi suggest improv prognosi howev success rate decreas increas sever diseas contrast affect root extract extrud hemi trisect lead coron displac diseas process signific improv situat hygien time resect inflammatori tissu periodont pocket accompani vertic horizont bone apposit result predict stabl long term burden patient low quintess int origin publish german quintessenz zahnmedizin doi jqib
D017823
T046
36,268,936
heteroaryl sulfen ion situ generat sulfinyl ester transit metal free condit heteroaryl sulfoxid integr part sever bioactiv molecul pharmaceut describ transit metal free rout direct sulfinyl halobenzothiazol halobenzimidazol use sulfinyl ester sourc sulfen ion presenc brnsted base lio bu correspond heteroaryl sulfoxid isol yield moreov hypothes plausibl concert nucleophil aromat substitut cs n ar pathway direct incorpor sulfinyl function haloheteroaren
D004952;D028561
T196;T109
36,268,935
evalu perceptu interact among ester odor nonvolatil organ acid baijiu gc ms gc odor threshold sensori analysi appli aroma extract dilut analysi ester found high fd factor laobaigan flavor type baijiu quantifi use gc ms addit nonvolatil organ acid quantifi derivat method combin gc ms perceptu interact lactic acid ethyl lactat lactic acid ethyl acet studi olfactori threshold curv use evalu chang olfactori threshold ad lactic acid mgl olfactori threshold ethyl lactat mgl ethyl acet mgl decreas obvious reveal lactic acid gave addit synergist odor effect two ester furthermor discov concentr lactic acid increas extent interact among compound also greater mixtur
D009812;D055549
T120;T070;T109
36,268,933
self organ vitro mous neural tube organoid mimic embryon develop embryon neural tube origin entir adult nervous system disturb develop caus life threaten birth defect howev studi mammalian neural tube develop limit lack physiolog realist three dimension vitro model report self organ neural tube organoid model deriv singl mous embryon stem cell exhibit vivo like tissu architectur cell type composit anterior posterior ap pattern moreov matur neural tube organoid show emerg multipot neural crest cell matur neuron singl cell transcriptom analys reveal sequenc transcript event emerg neural crest cell neural differenti thank access model phagocytosi migrat neural crest cell could observ real time first time mammalian model thus introduc tractabl vitro model studi key morphogenet cell type deriv event earli neural develop
D054259;D009940
T018;T024
36,268,904
obes patient report sexual health outcom gynecolog cancer survivor systemat review obes preval among gynecolog cancer gc survivor expect increas role obes sexual health need understood systemat review examin impact obes patient report sexual health outcom shos popul pubm embas web scienc cinahl psycinfo search origin studi publish follow prefer report item systemat review meta analys guidelin perform narrat synthesi find via cancer type cancer treatment sexual health measur countri eleven observ studi includ conduct european countri n report endometri cancer survivor n defin obes bodi mass index kgm n studi cervic cancer survivor report negat effect obes sexual activ bodi imag studi endometri cancer survivor report posit effect obes vaginalsexu symptom find suggest interact effect radiotherapi obes shos sexual function measur femal sexual function index less like associ obes shos posit effect obes shos found studi conduct european countri current evid associ obes sexual health gc survivor lack quantiti qualiti better understand effect obes shos popul studi need critic evalu obes sexual health measur care consider cancer type treatment focus cultur context obes
D000073116;D000074384;D016889
T201;T032;T191;T101
36,268,900
multipl genotyp crimean congo hemorrhag fever virus detect tick one health survey agnam northeastern seneg crimean congo hemorrhag fever virus cchfv survey agnam north seneg permit detect three isol tick isol belong genet multipl genotyp ii iii cluster strain uganda sudan mauritania seneg role tick cchf emerg widespread highlight
D003225;D013987;D006479
T005;T204;T047
36,268,899
insight soil dissolv organ matter ligand phenanthren bind properti base parallel faction analysi combin two dimension correl spectroscopi dissolv organ matter dom strong bind organ contamin control phenanthren soil herein four individu parallel factor analysi parafac compon found soil dom compon c humic like compon ligand compon c combin humic fluorophor ligand furthermor compon c c character terrestri ubiquit humic substanc modifi stern volmer complex model use reveal soil dom compon phenanthren bind properti overal bind characterist parafac compon could express phenanthren bind properti therefor two dimension correl spectroscopi use reveal dom ligand phenanthren bind properti bind phenanthren dom ligand c quench dom ligand c excit ligand higher humif present higher phenanthren bind abil promis result dom ligand phenanthren bind characterist offer theoret support soil pollut control
D012987;D010616
T121;T167;T109
36,268,894
end stage renal diseas incid cohort us firefight san francisco chicago philadelphia firefight perform strenuous work hot environ may increas risk chronic kidney diseas purpos studi evalu risk end stage renal diseas esrd type esrd among cohort us firefight compar us general popul examin exposur respons relationship
D061388;D007676
T090;T047
36,268,893
allevi neuroinflamm phototherm conjug polym nanoparticl regul reactiv oxygen speci ca signal neuroinflamm one import manifest amyloid peptid protein induc neurotox signal pathway aggreg caus increas reactiv oxygen speci ros ca concentr near infrar nir phototherm respons conjug polym nanoparticl design regul ros ca signal allevi neuroinflamm nm laser irradi nanoparticl effect penetr blood brain barrier bbb reduc aggreg partial disaggreg aggreg outsid cell therebi reduc ros content downregul oxid stress damag cell meanwhil nanoparticl reduc concentr ca inhibit transient receptor potenti melastatin relat trpm ion channel insid cell ultim concentr inflammatori factor tumor necrosi factor decreas studi provid effect strategi reduc neuroinflamm simultan regul ros ca signal
D053758;D050053
T123;T116;T073
36,268,885
three major gastrointestin cancer could distinguish subclass specif igg glycosyl esophag cancer ec gastric cancer gc colorect cancer crc three major digest tract tumor higher morbid mortal due signific molecular heterogen alter igg glycosyl observ inflammatori activ diseas progress igg glycom profil could use diseas stratif howev igg n glycom profil three cancer systemat investig herein subclass specif igg glycosyl crc gc ec comprehens character liquid chromatographi tandem mass spectrometri found igg sialyl decreas three cancer alter crc ec may subclass specif igg mono galactosyl increas three cancer subclass specif chang addit glycopeptid igg hn igg hnf igg hnf could distinguish three cancer group control fair diagnost perform furthermor bioinformat verifi differenti express relev glycosyltransferas gene cancer progress signific three gastrointestin cancer could distinguish use subclass specif igg glycan find demonstr spatial tempor divers igg n glycom among digest cancer increas understand molecular mechan ec gc crc pathogenesi
D007074;D005770
T129;T121;T191;T116
36,268,880
construct iodin label cs antibodi target pd l detect comparison low molecular peptid micro pet imag program death pd program death ligand pd l research focus immun checkpoint regul play import role tumor immunotherapi inhibitor pathway also focus tumor immunotherapi research pd pd l pathway block select bind pd l clinic trial conduct varieti patient advanc solid tumor cs high affin human full length anti pd l monoclon antibodi great clinic signific construct pd l target radioact molecular probe label full length antibodi cs evalu bind specif target abil pd l tumor cell tumor model addit comparison studi ga wl pd l target peptid conduct bind potenc cs human pd l evalu enzym link immunosorb assay elisa k valu nm cellular uptak cs examin chines hamster ovari cell cho cho express human pd l cho hpd l h uptak valu cs cho hpd l without block presenc mg non radiolabel cs ad cell p micro pet imag perform h inject cs normal km mice cho hpd l hela tumor model standard uptak valu suv relev organ pet imag calcul draw region interest roi suv mean cho hpd l tumor signific higher hela tumor h vs p suv mean cs cho hpd l tumor h higher ga wl cho hpd l tumor h vs suv mean p conclus work provid new method monitor evalu vivo express pd l tumor
D007455;D009369
T123;T196;T121;T191
36,268,872
generat integr hair follicl prime spheroid bioengin skin construct skin complex organ made differ cell layer appendag connect tissu immun repertoir differ compon interact extens maintain overal function integumentari system particular appendag hair follicl critic contribut skin function thermoregul sensori percept homeostat regener despit strong need better skin regen therapeut effort bio engin high function appendag contain human reconstitut skin vitro yield much success report method generat incorpor hair follicl prime heterotyp spheroid epiderm dermal skin construct induc invagin outgrowth follicl like organ lineag gene express co cultur epitheli keratinocyt kcs dermal papilla dp cell low attach plate establish media cultur condit best support viabil signal remodel cell aggreg form kc dp spheroid express dp induct hair follicl lineag gene show long term growth matur kc cell spheroid support incorpor epiderm dermal construct scaffold less media cultur bio fabric construct develop invagin integr spheroid follicl form potenti generat construct step toward develop function hair bear skin mimet
D018859;D012867
T022;T023
36,268,867
saccharothrix luteola sp nov novel cellulos degrad actinobacterium isol soil emend descript genus saccharothrix novel cellulos degrad actinobacterium design strain neau isol soil collect chifeng inner mongolia autonom region pr china character use polyphas approach pairwis similar rrna gene sequenc show strain neau repres saccharothrix close relat saccharothrix carnea neau yn saccharothrix saharensi sa saccharothrix texasensi dsm saccharothrix xinjiangensi nbrc physiolog chemotaxonom characterist strain support affili genus saccharothrix whole cell sugar contain galactos ribos mannos polar lipid contain diphosphatidylglycerol phosphatidylmonomethylethanolamin phosphatidylethanolamin phosphatidylinositol phosphatidylinositol mannosid predomin menaquinon mk h mk h mk h mk h major fatti acid iso c c anteiso c iso c iso c genom dna gc content mol level digit dna dna hybrid isol carnea neau yn saharensi sa texasensi dsm soap ani valu determin result indic strain neau could distinguish refer strain assembl genom sequenc strain neau found bp long ncbi prokaryot genom annot pipelin pgap reveal protein code gene genom analysi congo red stain test indic strain neau potenti degrad cellulos genom phenotyp result indic strain neau repres novel speci genus saccharothrix name saccharothrix luteola sp nov propos neau cctcc aa jcm type strain
D012987;D010714
T123;T167;T109
36,268,866
roseovarius carneus sp nov novel bacterium isol coastal phytoplankton bloom xiamen gram stain negat non motil ovoid short rod shape aerob marin bacterium design strain lxj isol coastal phytoplankton bloom xiamen pr china cell oxidas catalas posit strain lxj grew c optimum c ph optimum ph wv nacl optimum major cellular fatti acid iso c c iso c c c follow polar lipid found present phosphatidylglycerol phosphatidylethanolamin two unidentifi phospholipid five unknown glycolipid predomin respiratori quinon ubiquinon strain lxj exhibit highest rrna gene sequenc similar roseovarius litorisedimini w phylogenet tree base rrna gene sequenc show strain lxj member genus roseovarius draft genom size strain lxj mb genom gc content mol digit dna dna genom hybrid valu strain lxj compar similar type strain r litorisedimini cect averag nucleotid ident valu strain lxj r litorisedimini cect basi polyphas data strain lxj repres novel speci genus roseovarius name roseovarius carneus sp nov propos type strain lxj cgmcc mccc k jcm
D010714;D041902
T123;T007;T109
36,268,863
ideonella alba sp nov ideonella aquatica sp nov isol aquacultur farm three novel bacteri strain design isol aquacultur farm character use polyphas taxonom approach strain determin catalas oxidas posit hydrolyz gelatin aesculin result rrna gene base phylogenet analysi indic three strain relat member genus ideonella phylogenom result indic three strain form two independ branch distinct refer type strain within genus digit dna dna hybrid dddh averag nucleotid ident ani averag amino acid ident aai valu three strain relat far threshold dddh ani aai speci definit respect indic three strain repres two novel genospeci result chemotaxonom character indic major cellular fatti acid three strain sum featur c c andor c c c common main polar lipid diphosphatidylglycerol phosphatidylethanolamin phosphatidylglycerol respiratori quinon ubiquinon genom dna gc content three strain respect basi differ genotyp distinct phenotyp phosphatidylcholin glycolipid util malic acid trisodium citrat strain conclud repres two novel speci genus ideonella name ideonella alba sp nov type strain gdmcc kctc ideonella aquatica sp nov type strain gdmcc jcm propos
D014451;D000073556
T123;T121;T007;T109
36,268,862
hephaestia mangrovi sp nov novel endophyt bacterium isol aegicera corniculatum gram stain negat aerob motil rod shape bacterium design cmsp isol surfac steril bark aegicera corniculatum collect guangxi zhuang autonom region pr china investig polyphas approach determin taxonom posit strain cmsp found grow optim wv nacl c ph substrat mycelia aerial mycelia form diffus pigment observ media test phylogenet analysi show strain cmsp show high rrna gene sequenc similar hephaestia caeni dsm sphingomona colocasiea cc mhh averag nucleotid ident digit dna dna hybrid averag amino acid ident valu strain cmsp h caeni dsm respect averag nucleotid ident digit dna dna hybrid averag amino acid ident valu strain cmsp colocasiea jcm respect phylogenom analys base genom sequenc show strain cmsp h caeni dsm form distinct cluster within famili sphingomonadacea far away colocasiea jcm dna g c content strain cmsp determin mol cell wall peptidoglycan found contain meso diaminopimel acid diagnost diamino acid ubiquinon q identifi respiratori lipoquinon polar lipid found compris diphosphatidylglycerol phosphatidylglycerol phosphatidylcholin phosphatidylethanolamin sphingoglycolipid two unidentifi aminolipid major fatti acid identifi c c c cyclo c c basi phylogenet genom chemotaxonom phenotyp data strain cmsp conclud repres novel speci genus hephaestia name hephaestia mangrovi sp nov propos type strain cmsp jcm cgmcc
D029623;D042301
T007;T002
36,268,861
propos membranihabitan gen nov replac name illegitim prokaryot generic name membranicola li et al prokaryot generic name membranicola li et al illegitim later homonym name membranicola foissner berger schaumburg tintinnida principl rule b intern code nomenclatur prokaryot therefor propos replac generic name membranihabitan type speci membranihabitan marinus comb nov
D005227
T123;T168;T109
36,268,856
paenibacillus sabuli sp nov isol south china sea gram posit rod shape motil spore form bacterium design strain ib isol coastal sand south china sea strain grew optim ph c nacl predomin menaquinon mk major cellular fatti acid anteiso c iso c c polar lipid cell wall includ diphosphatidylglycerol phosphatidylglycerol phosphatidylethanolamin three unidentifi phospholipid one unidentifi lipid comparison rrna gene sequenc indic strain ib close relat paenibacillus sambharensi smb paenibacillus tarimensi sa similar respect whole genom averag nucleotid ident valu strain ib two refer strain digit dna dna hybrid valu respect genom analys show strain ib present genom mbp chromosom gc content total gene predict combin phylogenet related phenotyp genotyp featur support conclus strain ib consid repres novel speci genus paenibacillus propos name paenibacillus sabuli sp nov type strain ib mccc k jcm
D004269;D056507
T007;T114
36,268,852
phthalocyanin base nanoassembl switchabl fluoresc photoact tumor imag phototherapi switchabl theranost great interest accur tumor imag target therapi develop smart engin construct nanostructur phthalocyanin self assembl amphiphil zinc phthalocyanin znpcs hydrophob copper phthalocyanin cupc znpc peg cupc n znpc peg monosubstitut znpcs pentaethylen glycol substitu fluoresc reactiv oxygen speci generat znpc peg cupc n trigger depend membran tumor cell imag photoact concern stabil blood circul surfac nanocomplex coat polydopamin respond tumor acid microenviron znpc peg cupc focus photodynam phototherm properti respect stimul singl laser beam endow znpc peg cupc n combin antitumor effect evalu vitro vivo studi mechan switchabl theranost strategi combin photodynam phototherm therapi smart nanoengin technolog phthalocyanin poor water solubl appli phthalocyanin phthalocyanin like phototherapi agent
D010778;D009942;D009369
T061;T191;T109
36,268,850
electrocatalyt three compon synthesi halopyrazol sodium halid halogen sourc first exampl electrocatalyt multicompon synthesi chlorobromoiodopyrazol hydrazin acetylaceton sodium halid chemic oxid extern electrolyt free condit develop sodium halid play dual role halogen reagent support electrolyt mechan studi reveal bromin reaction proceed via ionic pathway wherea chlorin iodin proceed via radic pathway
D006219;D012964
T123;T196;T034
36,268,840
exercis benefici patient low back pain cochran review summari commentari aim commentari discuss rehabilit perspect cochran review exercis therapi chronic low back pain hayden ja elli j ogilvi r malmivaara van tulder mw publish cochran musculoskelet group cochran corner produc agreement journal rehabilit medicin cochran rehabilit view review summari author implic practic section summari base cochran review previous publish cochran databas systemat review issu art cd doi cdpub see wwwcochranelibrarycom inform cochran review regular updat new evid emerg respons feedback cochran databas systemat review consult recent version review view express summari commentari cochran corner author differ origin cochran review author repres cochran librari journal rehabilit medicin
D017116;D010810
T184;T047;T091
36,268,835
role terphenyl contain carboxyl acid oligomer aryl vinyl keton molecular structur r butylcyclohexyl chloro terphenyl yl oxi oct en one terph vk r butylcyclohexyl chloro terphenyl yl oxi hexano acid terph cooh analyz ftir spectroscopi vinyl keton isol solut form thermodynam unstabl cis conform due probabl peculiar crystal structur format heat substanc c result cis tran transform simultan open vinyl doubl bond mix terphenyl solut follow isol solid product result format terph vkterph cooh associ speci due h bond keton carboxyl group thermal transform h bond associ speci result format oligo terph vk terph cooh associ speci
D002264;D013730
T109
36,268,821
look crystal ball print pattern self assembl peptid nanostructur solut process organ semiconductor conjug polym along advent nanomateri conduct ink revolution next generat flexibl consum electron anoth equal import class nanomateri self assembl peptid herald next generat materi bioelectron lot potenti print technolog minireview address self assembl process dipeptid applic electron recent progress three dimension print prospect generaliz path nanopattern self assembl peptid use ice lithographi challeng discuss
D049329
T073
36,268,817
endur train affect maximum exertiondist capac anoli carolinensi lizard locomotor perform abil key predictor surviv reproduct success anim understand select target provid insight morpholog physiolog relat fit despit larg bodi work perform trait along well establish protocol measur perform challeng measur endur instanc common measur record long anim run set pace exhaust time consum requir dedic equip consequ exert distanc capac measur distanc run exhaust chase often use proxi endur relationship two metric never assess even though like reli differ under physiolog mechan test experiment relationship endur exert train green anol lizard sprint endur measur whether exert capac respond either type train prior train across treatment male display mean sd exert capac femal train respect found exert capac unaffect either type train green anol also show posit relationship endur exert capac pre train exist femal relationship inconsist among studi exert studi locomotor trait right proxi endur
D008116;D000076663;D010805
T014;T038;T061
36,268,809
novel deep eutect solvent base protein extract method potteri residu archeolog implic proteom analysi absorb residu increas use identifi foodstuff process ancient ceram vessel detail methodolog investig field remain rare present three interlink methodolog develop import consequ paleoproteom compar absorpt identif various food protein applic deep eutect solvent des extract ceram bound protein role databas choic taxonom identif experi modern ethnoarcheolog ceram show des general effect extract ceram bound protein guanidin hydrochlorid guhcl cereal protein absorb subsequ extract identifiedat least readili meat protein also highlight challeng cross speci proteom wherebi speci less well repres databas attribut incorrect speci level taxonom assign due interspeci similar protein sequenc particular problemat potenti mix sampl cook generat organ residu deposit potteri work demonstr possibl proteom separ fish bird latter far elud detect lipidom analys organ residu deposit potteri import implic track exploit avian speci various ancient communiti around globe
D000091463;D040901
T120;T091
36,268,802
calcul permeabl coeffici small molecul lipid bilay free energi reaction network analysi follow explicit treatment intern conform solut biomembran permeat repres major barrier pharmacokinet preclin drug discoveri coeffici permeat molecul lipid bilay account valuabl properti molecul therefor control permeat molecul lipid bilay essenti factor drug design estim permeat phenomena crucial studi pharmaci thus mani publish studi theoret estim permeat coeffici propos molecular dynam md simul method estim permeat small molecul lipid bilay base free energi reaction network fern analysi method collect variabl cvs free energi calcul explicit includ conform chang rotat bond solut molecul advantag present method method possibl estim reaction pathway reaction rate ie permeat coeffici passag time multidimension space span cvs though convent method umbrella sampl method target mds often dealt degre freedom demonstr efficaci method calcul coeffici permeat three small aromat peptid name n acetylphenylalanineamid ac phe nh nafa n acetyltyrosineamid ac tyr nh naya n acetyltryptophanamid ac trp nh nata dioleoyl sn glycero phosphocholin dopc lipid bilay case adopt one cv permeat direct four cvs intern rotat coordin result reveal permeat coeffici nafa naya nata cm respect compar experiment data simul result follow trend ie nafa nata naya analyz structur metast point solut molecul simul result reveal aforement trend caus differ stabil among rotam furthermor evalu statist fluctuat rotam time scale flip side chain reveal structur rigidifi ligand move deeper membran
D008051;D056004
T026;T066;T044
36,268,800
forc loss induc inhibit cross bridg cycl mitig eccentr contract examin whether forc loss induc butanedion monoxim affect isometr eccentr forc differ singl skin muscl fiber activ averag sarcomer length stretch trial perform without butanedion monoxim calcul magnitud forc loss attain sever time point pre stretch phase eccentr phase end eccentr contract post stretch phase magnitud forc loss signific larger pre stretch phase time point mitig forc loss eccentr contract promin long condit short condit suggest eccentr forc relat preserv compar refer isometr forc pre stretch cross bridg cycl inhibit possibl contribut elast forc produc titin
D007537;D018485
T025;T042
36,268,799
subset leg proprioceptor influenc leg kinemat interleg coordin drosophila melanogast walk leg locomot terrestri anim often essenti mate surviv locomotor behavior must robust adapt success adapt larg provid proprioceptor monitor posit movement bodi part provid feedback compon locomotor network insect propriocept chordoton organ span joint encod paramet relat movement segment previous studi use whole organ ablat reduc prepar broad physiolog manipul impair function femor chordoton organ fco monitor femur tibia joint demonstr contribut interleg coordin walk behavior fco drosophila melanogast compris group neuron differ morpholog encod properti club hook claw sub popul level manipul fco function methodolog access took advantag genet toolkit avail melanogast identifi sub popul fco neuron use transient optogenet inhibit investig role locomotor coordin find demonstr optogenet inhibit subset club hook neuron replic effect inhibit whole fco inhibit alon howev individu subset type strong affect spatial aspect singl leg kinemat moreov fco subset seem play minor role interleg tempor coordin thus fco contain function distinct subgroup function classif may differ base anatomi encod properti investig futur studi proprioceptor involv locomotor network
D004331;D009046
T025;T204
36,268,795
character cuticular wax tea plant modif respons low temperatur cuticular wax ubiquit cover outer layer plant protect various abiot biotic stress nevertheless characterist cuticular wax role cold resist tea plant remain unclear studi cuticular wax differ tissu cultivar leav differ spatio tempor growth stage character compar tea plant composit distribut pattern structur profil cuticular wax show consider tissu specif particular petal seed spatial develop tea leav total wax content increas first fifth leaf june decreas pattern observ septemb addit total wax content number wax compound enhanc wax composit signific vari leaf growth june septemb ten cultivar show consider differ total wax content composit predomin satur fatti acid primari alcohol syh hji cultivar respect correl analysi suggest n hexadecano acid posit relat cold resist tea plant transcriptom analysi cold sensit ajbc cold toler cyq ec cultivar indic induc express wax relat gene associ cold toler differ cultivar respons cold stress result reveal character cuticular wax tea plant provid new insight modif cold toler
D014885;D028241
T122;T002
36,268,793
zarconia navali gen nov sp nov romeriopsi navali gen nov sp nov romeriopsi marina sp nov isol inter subtid environ northern portug morpholog rrna gene phylogeni rrna gene secondari structur three strain marin cyanobacteria isol inter subtid environ north portug studi result descript zarconia navali gen nov sp nov oscillatorial incerta sedi romeriopsi navali gen nov sp nov leptolyngbyacea romeriopsi marina sp nov name intern code nomenclatur alga fungi plant diacrit morpholog charact found new genera speci rrna gene maximum likelihood bayesian phylogeni support genus zarconia member oscillatorial morpholog similar genera microcoleus phormidium distant genus romeriopsi posit within leptolyngbyacea synechococcal close relat alkalinema secondari structur box b v v helic corrobor phylogenet result furthermor studi support previous observ polyphylet oscillatorial famili reinforc need taxonom revis
D005227;D000458
T123;T168;T007;T109
36,268,790
halogen atom transfer xat base approach indol synthesi use aryl diazonium salt alkyl iodid indol among import n heterocycl pharmaceut present altern classic fischer indol synthesi base radic coupl aryl diazonium alkyl iodid iron mediat strategi featur doubl role aryl diazonium sequenti activ alkyl iodid halogen atom transfer serv radic acceptor process oper mild condit enabl prepar dens function indol
D007454;D012492
T104;T197
36,268,784
popul growth perform arma custo faricius hemiptera pentatomida differ temperatur arma custo fabricius hemiptera pentatomida natur predat control various agricultur forestri pest studi aim clarifi effect temperatur growth reproduct popul predat simul popul growth use age stage two sex life tabl method c c c c c select temperatur condit custo complet life cycl c c development durat custo stage adult pre oviposit period total pre oviposit period mean generat time shorten increas temperatur pre adult mortal signific reduc c c addit fecund singl femal gross reproduct rate highest c signific differ observ intrins rate increas r finit rate increas differ temperatur condit reach maximum c result show adult custo rais c longer lifespan fecund higher c comparison temperatur studi first report life cycl custo differ temperatur result provid scientif theoret basi indoor artifici reproduct outdoor releas colon custo
D006430;D020062
T204
36,268,783
therapeut use calpeptin covid infect perspect consid benefit potenti futur use cell permeant calpain inhibitor calpeptin drug treat sever acut respiratori syndrom coronavirus sar cov infect recent work report calpeptin capac inhibit entri virus cell elsewher sever drug includ calpeptin found abl inhibit extracellular vesicl ev biogenesi unsurpris similar viral ev releas mechan calpeptin also shown inhibit viral egress approach identifi calpeptin larg scale screen studi candid drug treat covid howev consid longer term like benefit calpain inhibit post covid perspect reflect capac calpeptin treat long covid inhibit overproduct neutrophil extracellular trap potenti damag lung cell promot clot togeth limit associ chronic inflamm tissu damag pulmonari fibrosi also reflect toler detriment vivo side effect calpain inhibit various preclin studi
D000086382
T047;T067
36,268,773
analyz excit energi transfer base time depend densiti function theori real time excit energi transfer key step process photosynthesi convert light form energi time depend densiti function theori dft real time ideal first principl simul process due comput effici demonstr real time dft use analyz excit energi transfer first principl discuss sever measur energi transfer base sole time depend densiti well found dft framework allow intuit understand visual reproduc import limit case analyt model demonstr use calcul model system static nuclei context dft base ehrenfest dynam
D011789;D004583
T081;T196;T170
36,268,768
indic asept revis tka influenc year outcom analysi full tka revis prospect institut registri outcom follow revis total knee arthroplasti tka may depend indic revis surgeri compar pain patient report outcom measur prom patient satisfact among differ indic asept tka revis
D019645
T061
36,268,764
new onset atrial fibril orthotop liver transplant induc ice salin inject transpulmonari thermodilut case report transpulmonari thermodilut often use measur extravascular lung water liver transplant case new onset atrial fibril orthotop liver transplant may induc ice salin inject transpulmonari thermodilut measur describ year old male patient underw orthotop liver transplant due alcohol cirrhosi combin portal hypertens dissect recipi liver transpulmonari thermodilut perform minut follow ice salin inject atrial fibril occur ventricular rate increas beat per min blood pressur drop mmhg massiv haemorrhag inferior vena cava clamp electrolyt disord acid base balanc disord hypothermia rule ice salin inject suspend hemodynam stabil maintain phenylephrin lanatocid c cedilanid chemic cardiovers perform use amiodaron reperfus phase transient hemodynam instabl manag norepinephrin neohepat phase unev atrial fibril last day revers sinus rhythm automat patient hemodynam stabl period recoveri smooth thromboembol event conclus atrial fibril may induc ice salin inject transpulmonari thermodilut measur orthotop liver transplant
D001281;D016031;D000638
T061;T121;T109;T047;T046
36,268,763
patholog cathet relat complic need know discov despit consider effort made increas preval autogen fistula patient hemodialysi tunnel cuf cathet still import access modal use high percentag hemodialysi popul howev conundrum pose tunnel cuf cathet patient develop multitud complic includ thrombosi infect format fibrin sheath central vein stenosi result increas morbid mortal well place heavi burden healthcar system howev increas number studi focus manag cathet relat complic less translat research patholog complic review recent literatur provid updat patholog aspect cathet relat complic highlight need know yet discov futur research strategi innov need prevent complic also address
D002405;D062905;D055499
T061;T074;T046
36,268,762
effici one pot synthesi aryl pyrazol fuse pyran analog lead treat diabet alzheim diseas background discov novel lead molecul diabet alzheim diseas oxid stress librari aryl pyrazol fuse pyran deriv synthes one pot reaction materi method h nmr spectroscop electron ionize mass spectrometri techniqu use character synthet hybrid molecul analog screen four indispens therapeut target includ amylas glucosidas acetylcholinesteras butyrylcholinesteras enzym result except deriv compound exhibit vari degre inhibitori activ target enzym kinet studi reveal synthet molecul follow competit type mode inhibit amylas acetylcholinesteras enzym well non competit mode inhibit glucosidas butyrylcholinesteras enzym addit molecular dock studi identifi crucial bind interact ligand enzym activ site conclus molecul may serv potenti drug candid cure diabet alzheim diseas oxid stress futur
D000544;D003920
T047;T048
36,268,757
associ tissu human neutrophil peptid level cardiovascular phenotyp prospect longitudin cohort studi inflamm associ atherogenesi although higher neutrophil count associ plaqu burden role neutrophil activ unclear human neutrophil peptid hnp risk factor atherogenesi bench model elev human atheroma studi aim examin associ skin hnp deposit sever coronari arteri diseas cad includ long term outcom
D023084;D003324;D058226;D050197
T129;T121;T116;T020;T047;T046;T031
36,268,752
use spong assist endolumin vacuum therapi treatment colorect anastomot leak expert panel consensus anastomot leak repres one signific complic colorect surgeri primari caus postop mortal morbid spong assist endolumin vacuum therapi evt emerg minim invas techniqu manag anastomot leak howev question regard patient select due heterogen natur anastomot leak applic spong assist evt surgeon
D054843;D015179
T061;T074;T191
36,268,751
clinic correl earli onset antipsychot treatment resist evid heterogen within treatment resist schizophrenia trs peopl respond antipsychot treatment ill onset other becom treatment resist initi respons period group may differ aetiolog
D014150;D012559;D003024
T121;T039;T109;T048
36,268,750
deep insight viscos deep eutect solvent xgboost base model plus shapley addit explan deep eutect solvent dess emerg novel green solvent process mass transport heat transfer viscos dess import industri applic howev dess measur viscos time consum mani factor influenc viscos imped wider applic studi aim develop data driven model could accur rapid predict viscos divers dess differ temperatur furthermor boost design screen novel dess work collect dess experiment valu viscos publish work given signific effect water viscos water content collect des label morgan fingerprint first employ featur describ chemic environ dess four machin learn algorithm use train model support vector regress svr random forest rf neural network nn extrem gradient boost xgboost xgboost show best predict perform combin power interpret method shapley addit explan shap reveal posit negat effect featur viscos overal work provid machin learn model could predict viscos precis facilit design applic dess
D000091463;D014867
T120;T121;T197
36,268,748
metabol signatur immun cell chronic kidney diseas immun cell play key role maintain renal dynam balanc deal renal injuri physiolog patholog function immun cell intric connect metabol characterist howev immunometabol chronic kidney diseas ckd fulli understood pathophysiolog disrupt kidney immun cell homeostasi caus inflamm tissu damag via trigger metabol reprogram divers metabol characterist immun cell differ stage ckd strong associ differ patholog effect work review metabol characterist immun cell macrophag natur killer cell cell natur killer cell b cell sever non immun cell well potenti treatment target immunometabol ckd attempt elabor metabol signatur immun cell intim correl non immun cell ckd
D051436
T047