PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,261,831 | tumor buster car cell therapi missil go chimer antigen receptor car cell car cell therapi base gene edit technolog repres signific breakthrough person immunotherapi human cancer strategi use genet modif enabl cell target tumor specif antigen attack specif cancer cell bypass tumor cell apoptosi avoid mechan extent method extens use treat hematolog diseas therapeut effect solid tumor ideal tumor antigen escap treatment relat toxic immunosuppress tumor microenviron tme limit use target select critic aspect determin prognosi patient receiv treatment review provid comprehens summari therapeut target use clinic shown promis potenti summar car cell therapi clinic trial applic research frontier limit treat differ cancer also explor cope strategi encount sub optim tumor associ antigen taa taa loss moreov import car cell therapi cancer immunotherapi emphas | D000076962;D009369 | T129;T191;T116;T192 |
36,261,830 | turn heat non immunoreact tumor autophagi influenc immun microenviron pancreat cancer autophagi regul play import role occurr develop varieti tumor involv immun regul drug resist howev modulatori role prognost valu autophagi regul pancreat cancer identifi | D010190 | T191 |
36,261,829 | preval peri implant systemat review meta analysi peri implant usual find estim preval fluctuat much may due wide varieti diseas definit systemat review aim estim overal preval peri implant effect differ studi design function time use probe depth preval rate | D057873;D015921 | T047;T074 |
36,261,827 | name gp increas self report access health care servic continu care strengthen health promot decreas mortal although mechan effect still unclear recent decad continu care access health care servic decreas finland | D003266;D006296 | T058 |
36,261,826 | patient view use human embryon stem cell treat parkinson diseas interview studi human embryon stem cell hesc sourc develop advanc therapi medicin product consid treatment parkinson diseas pd research shown promis result open avenu great import patient current lack diseas modifi therapi use hesc given rise moral concern focus often heat debat moral status human embryo approv market still pend | D000066449;D010300 | T047;T025 |
36,261,825 | back rx person mobil phone applic discogen chronic low back pain prospect pilot studi intervertebr disc patholog common identifi caus chronic lower back pain clbp limit conserv altern treat discogen axial clbp back rx mobil applic app develop treat patient condit follow back rx exercis program assist virtual coach | D040421;D059350;D017116;D063731 | T184;T047;T170;T073 |
36,261,824 | systemat review meta analysi head head trial compar sulfonylurea low hypoglycaem risk antidiabet drug safeti sulfonylurea drug treatment type diabet still debat aim studi compar caus mortal cardiovascular advers event sulfonylurea drug low risk hypoglycaemia adult type diabet | D003924;D054873;D008687;D000077203;D007003;D027981 | T121;T123;T116;T109;T047 |
36,261,823 | implement barrier enabl midwiferi group practic vulner women qualit studi tertiari urban australian health servic matern servic limit formalis guidanc plan new servic midwiferi group practic vulner women exampl women histori substanc abus alcohol tobacco drug mental health challeng complex social issu vulner continu care midwiferi group practic most restrict women low risk pregnanc univers avail vulner women despit evid support benefit model care women percept midwiferi group practic vulner women high risk model care lack evid may past thwart implement plan studi seek improv care women therefor aim identifi barrier enabl might impact implement midwiferi group practic vulner women | D008880;D008427;D000068376;D006123 | T091;T093;T097;T058;T048 |
36,261,822 | aesthet reconstruct onco surgic maxillari defect use free scapular flap without cadcam custom osteotomi guid reconstruct maxillari defect follow tumor ablat remain challeng surgeon virtual surgic plan vsp intraop cut guid stereolithograph model provid head neck reconstruct surgeon power tool complex reconstruct plan despit use fibular osteocutan reconstruct applic scapular free flap wide report aim studi compar aesthet result oper time free scapular flap without comput aid design comput aid manufactur cadcam custom osteotomi guid reconstruct maxillari defect | D019651;D008441 | T061;T191 |
36,261,821 | research pharyng bacteri flora transor atlantoaxi oper postop follow studi studi chang bacteri flora seri preoper oral disinfect postop recoveri nerv function patient craniovertebr junction disord treat transor approach oper | D013123 | T061 |
36,261,820 | surgic product suffer despit state emerg covid pandem japan retrospect observ studi purpos studi comput surgic total factor product malmquist index evalu effect state emerg novel coronavirus diseas covid pandem product chang hypothes state emerg signific reduc surgic total factor product japan | D000086382 | T047;T067 |
36,261,819 | pariti esteem system think theori inform qualit induct themat analysi pariti esteem poe equal mental physic health term lack definit clariti complex field mental health convers around poe add opac therefor aim studi use system think explor strength challeng use poe | D003695;D003142 | T080;T093;T170;T054;T097;T058 |
36,261,818 | llin evalu uganda project llineup factor associ coverag use longlast insecticid net follow nation mass distribut campaign cross section survey district long last insecticid net llin distribut nationwid uganda covid pandem cross section survey conduct district evalu impact campaign month llin distribut | D000086382;D057148 | T047;T074;T067 |
36,261,817 | marp therapi effect intracrani pressur clinic studi aim evalu possibl intracrani pressur icp chang caus screw activ activ microimpl assist rapid palat expans marp therapi post pubert individu measur optic nerv sheath diamet onsd ultrasonographi us guidanc | D007427;D019586 | T033;T042 |
36,261,815 | hybrid long short term memori neural network autoregress integr move averag model forecast hiv incid moral post neonat popul east asia global burden diseas forecast human immunodefici virus hiv incid mortal post neonat popul east asia includ north korea south korea mongolia japan china mainland taiwan provinc | D000071219;D015658;D015233 | T081;T047;T170 |
36,261,814 | detect fibular rotat chang cone beam ct experiment studi specimen model syndesmot injuri incorrect reduct lead earli arthrosi ankl joint abl analyz reduct result therefor crucial obtain anatom reduct sever studi assess fibular rotat incisura alreadi publish aim studi valid measur method use cone beam comput tomographi imag detect rotat malposit fibula standard specimen model | D005360;D016512 | T023;T037 |
36,261,813 | observ clinic effect huoxu jiangtang decoct formula granul treat prediabet random prospect placebo control doubl blind trial protocol prediabet hypermetabol syndrom blood sugar level fall normal diabet peopl prediabet signific increas chanc develop diabet cardiovascular cerebrovascular diseas tumor dementia diseas futur compar healthi popul howev prediabet main treat base lifestyl intervent current without target drug treatment plan tradit chines medicin tcm longstand experi shown clinic studi effect treatment diabet relat complic furthermor differ dosag form decoct granul develop gradual clinic applic preliminari studi found huoxu jangtang decoct hjd good hypoglycem lipid regul effect potenti one complementari altern treatment prediabet therefor project intend perform prospect clinic studi observ clinic effect hjd prediabet consist efficaci formula granul elix | D011236;D003920 | T047 |
36,261,812 | influenc baselin arteri stiff effect intens compar standard blood pressur control post hoc analysi step trial benefit risk intens versus standard systol blood pressur sbp treatment older patient arteri stiff remain unclear studi aim investig interact baselin sbp treatment cardiovascular outcom | D006973;D059289 | T047;T046 |
36,261,811 | associ macrovascular complic intens care admiss invas mechan ventil mortal peopl diabet hospit coronavirus diseas covid clear whether pre exist macrovascular complic ischem heart diseas stroke peripher arteri diseas associ health outcom peopl diabet mellitus hospit covid | D000086382;D003920;D017202 | T047;T067 |
36,261,810 | efficaci safeti curcuminoid alon allevi pain dysfunct knee osteoarthr systemat review meta analysi random control trial curcuminoid cur princip ingredi curcuma longa l zingiberacea cl herbal plant use east asia allevi pain inflamm thus far therapeut effect cur knee osteoarthr oa uncov multipl review remain uncertain due broad involv trial differ agent combin cur free intervent therefor form stringent select criteria assess method summar current evid efficaci safeti cur alon treatment knee oa | D020370 | T047 |
36,261,808 | popul level counterfactu trend model examin relationship smoke preval e cigarett use among us adult studi suggest us adult smoker switch away smoke e cigarett use nation repres data may reflect chang smoke assess trend cigarett e cigarett preval object studi assess whether much smoke preval differ expect sinc introduct e cigarett | D000072137;D066300 | T055;T073 |
36,261,807 | modul immunolog respons aqueous extract datura stramonium l seed cyclophosphamid induc immunosuppress wistar rat datura stramonium l solanacea use tradit west africa treat asthma epilepsi rheumatoid arthriti filariasi microbi infect conjunct studi investig immunomodulatori effect aqueous seed extract stramonium l ase wistar rat | D002392;D013286;D012503 | T121;T002;T109 |
36,261,806 | associ cancer stem cell gene express signatur prognosi head neck squamous cell carcinoma various cancer stem cell csc biomark gene encod head neck squamous cell carcinoma hnscc identifi evalu howev valid factor prognosi hnscc question remain unclear studi examin clinic signific csc biomark gene hnscc use five public avail hnscc cohort | D006258;D030361;D002294 | T047;T191 |
36,261,805 | estim optim linear combin predictor use spheric constrain optim context binari classif problem optim linear combin continu predictor estim maxim area receiv oper characterist curv ordin respons optim predictor combin similar obtain maxim hypervolum manifold hum sinc empir hum discontinu non differenti possibl multi modal solv maxim problem requir global optim techniqu estim optim coeffici vector use exist global optim techniqu comput expens becom prohibit number predictor number outcom categori increas | D000465 | T170 |
36,261,804 | map cis regulatori modul constitu transcript factor bind site mous genom mous probabl import model organ studi mammal biolog human diseas better understand mous genom help understand human genom biolog diseas howev despit recent progress character regulatori sequenc mous genom still far complet limit use understand regulatori sequenc human genom | D050436;D015894 | T028 |
36,261,803 | reconstruct neuromuscular ground pattern phylactolaem bryozoan new data lophopodida sole freshwat inhabit phylactolaemata sister taxon bryozoan among phylactolaem lophopodida repres earli branch clade therefor crucial ground pattern reconstruct recent morpholog data phylactolaem famili present data lophopodid scarc genus asajirella especi previous assign famili pectinatellida lack detail analysi recent morpholog method | D002013 | T204 |
36,261,802 | metagenom analysi reveal differ co occurr abund viral speci sar cov patient differ sever diseas sar cov infect wide spectrum clinic manifest whose caus complet understood human condit predispos sever outcom like old age presenc comorbid mani facet includ coinfect virus remain poor character | D000086382;D060085;D014780 | T047;T005;T067 |
36,261,801 | evalu continuum matern newborn healthcar rwanda evid rwanda demograph health survey access complet continuum matern child health care recommend global better pregnanc outcom henc studi determin level pool preval predictor success complet continuum care coc rwanda | D006268;D008393 | T073;T080;T055;T093;T062;T033;T079;T054;T081;T072 |
36,261,800 | toward healthier sustain diet australian context comparison current diet australian dietari guidelin eat lancet planetari health diet increas focus move popul toward healthier environment sustain dietari pattern australian dietari guidelin provid dietari pattern promot health wellb unclear guidelin align recent publish global recommend eat lancet planetari health refer diet australian diet compar set recommend | D006293;D002118 | T121;T123;T196;T170;T058 |
36,261,799 | pregnanc outcom follow offspr donor oocyt recipi pcos patient use donat oocyt vitro fertil ivf treatment patient infertil general recogn femal polycyst ovarian syndrom pcos particip oocyt donat program donor patient howev pregnanc outcom offspr follow patient pcos recipi unclear studi compar pregnanc outcom follow offspr pcos non pcos receptor | D011085;D011271 | T047;T046 |
36,261,798 | birth registr coverag accord sex head household analysi nation survey low middl incom countri within countri inequ birth registr coverag brc document accord wealth place resid household characterist investig whether sex head household associ brc | D003906;D007182 | T078;T081;T080 |
36,261,797 | associ water sanit hygien wash child undernutrit ethiopia hierarch approach undernutrit signific public health challeng one lead caus child mortal wide rang develop countri includ ethiopia poor access water sanit hygien wash facil common contribut child growth failur pauciti inform interrelationship wash child undernutrit stunt wast studi aim assess associ wash undernutrit among five year old children ethiopia | D060766;D015362;D044342 | T047;T167 |
36,261,796 | effect australian communiti suicid prevent network program prevent suicid control longitudin studi suicid major issu affect communiti around world communiti base suicid prevent approach tailor activ local level recognis key compon nation suicid prevent strategi despit research explor effect complet suicid rare studi examin effect nation program communiti suicid prevent network suicid rate catchment area across australia | D013405 | T033 |
36,261,795 | compar analysi complet chloroplast genom six threaten subgenus gynopodium magnolia speci subgenus gynopodium belong genus magnolia high ornament econom ecolog valu subgenus gynopodium contain eight speci six speci threaten studi date character characterist chloroplast genom cpgs within subgenus gynopodium speci studi compar structur cpgs identifi mutat hotspot resolv phylogenet relationship subgenus gynopodium | D054628;D031566;D029562 | T002;T028 |
36,261,794 | prognost valu patient report outcom measur prom adult non small cell lung cancer scope review grow interest collect use patient report outcom measur prom support clinic decis make patient non small cell lung cancer nsclc howev overview research prognost valu prom current lack | D002289;D008175 | T191 |
36,261,793 | complet genom sequenc comparison two nitrogen metabol bacteria isol antarct deep sea sediment bacteria essenti compon earth biota affect circul matter metabol activ also play import role carbon nitrogen cycl deep sea environ paper two strain deep sea sediment investig order understand nitrogen cycl involv deep sea environ | D009584;D001419 | T123;T196;T007 |
36,261,792 | energi transport function heptahel transmembran protein photoprotein bacteriorhodopsin br rhodopsin rho need effect dissip photoinduc excess energi prevent damag anoth well studi seven transmembran tm helic protein adrenerg receptor ar g protein coupl receptor energi dissip path link alloster communic studi vibrat energi transport activ inact state protein master equat approach j chem phys employ use scale rule allow us calcul energi transport rate sole base protein structur despit overal structur similar three tm protein reveal quit differ strategi redistribut excess energi br quick remov energi use tm helix lightn rod rho exhibit rather poor energi dissip might eventu requir hydrolysi schiff base protein retin chromophor prevent overh heat ligand adrenalin ar result energi transport network protein found chang signific upon switch activ state inact state energi flow may highlight aspect inter residu coupl ar seem particular suit explain alloster phenomena | D001436 | T123;T116 |
36,261,791 | high smoke low cessat rate among patient treatment opioid substanc use disord smoke well document caus health problem among individu substanc use disord patient opioid mainten treatment omt risk somat health problem includ prevent diseas associ tobacco smoke increas age aim describ smoke among patient enter substanc use disord sud treatment investig chang smoke start treatment year follow explor factor relat smoke cessat | D016540;D019966 | T033;T055;T048 |
36,261,790 | investig health servic avail readi antenat test treatment hiv syphili papua new guinea papua new guinea png one highest burden hiv syphili pregnanc asia pacif region time effect diagnosi allevi burden hiv syphili improv matern newborn health suppli side factor relat implement scale remain problemat yet studi consid impact antenat test treatment hiv syphili studi explor health servic avail readi antenat hiv andor syphili test treatment png | D013587;D015658 | T047 |
36,261,789 | pesticid residu exposur provid differ respons microbiom distinct cultur store product pest mite acarus siro contribut microbiom pesticid breakdown agricultur pest remain unclear analyz effect pirimipho methyl pm four geograph differ cultur store product pest mite acarus siro l tu tk z laboratori experi effect pm mite mortal impregn filter paper test compar | D040041;D010573;D008925;D064307 | T032;T131;T204;T028;T001 |
36,261,788 | resistom mycobacteroid abscessus complex possibl acquisit horizont gene transfer mycobacteroid abscessus complex mabc emerg pathogen caus human infect resist multipl antibiot studi genom data mabc strain download ncbi databas phylogenet related infer resist profil identif estim evolutionari pressur resist gene silico | D000073358 | T007 |
36,261,787 | communiti composit trophic mode divers fungi associ fruit bodi medicin sanghuangporus vaninii microbi symbiont macrofung fruit bodi shown play moment role host growth develop secondari metabol nevertheless report fungal divers sanghuangporus medicin edibl homolog macrofungus forest gold good effect antioxid boost immun cure stomachach divers function group fungi associ fruit bodi wide appli vaninii character high throughput sequenc funguild tool first time | D001487;D001203 | T004 |
36,261,786 | studi prognosi immun drug resist relat gene lung cancer studi demonstr relationship relat gene prognosi tumor microenviron drug resist lc | D000241;D008175 | T123;T121;T109;T191;T114 |
36,261,785 | case report long segment myeliti secondari neuro melioidosi neuro melioidosi compris case melioidosi carri risk high morbid mortal describ two sri lankan patient present long segment myeliti secondari melioidosi | D008554;D009187 | T047 |
36,261,784 | intern medic student accultur self rate health status hungari cross section studi past decad number intern student increas dramat student adjust unfamiliar social cultur educ environ concept accultur appli multipl studi various health outcom studi investig relationship accultur self rate health srh among intern medic student | D000069;D013337 | T097;T054 |
36,261,783 | associ low mix venous oxygen satur earli icu stay increas day year mortal cardiac surgeri singl center retrospect studi low postop mix venous oxygen satur svo valu link poor outcom cardiac surgeri present studi design assess whether svo valu intens care unit icu admiss h admiss associ increas mortal cardiac surgeri | D000089382;D006348 | T201;T061 |
36,261,779 | potenti limit monitor pesticid biodegrad trace concentr water soil pesticid applic agricultur field result pesticid releas environ reach soil surfac water groundwat pesticid fate transform environ depend environment condit well physic chemic biolog degrad process monitor pesticid biodegrad environ challeng consid tradit indic chang pesticid concentr identif pesticid metabolit suitabl mani pesticid anaerob environ furthermor indic distinguish biotic abiot pesticid degrad process reason use molecular tool import monitor pesticid biodegrad relat gene microorgan environ develop target molecular eg qpcr tool although labori allow biodegrad monitor target presenc express known catabol gene popular pesticid explor molecular tool ie metagenom metatranscriptom requir extens data analysi prove potenti screen biodegrad potenti activ one compound time applic molecular tool develop laboratori valid control environ face challeng appli field due heterogen pesticid distribut well natur environment differ howev monitor pesticid biodegrad field use molecular tool combin metadata import tool understand fate transform differ pesticid present environ | D010575;D060587 | T081;T131;T070;T082 |
36,261,766 | msran multi scale residu attent network multi model imag fusion fusion critic step imag process task recent deep learn network consider appli inform fusion signific limit exist imag fusion method inabl highlight typic region sourc imag retain suffici use inform address problem paper propos multi scale residu attent network msran fulli exploit imag featur generat network contain two inform refin network one inform integr network inform refin network extract featur differ scale use convolut kernel differ size inform integr network merg block attent block ad prevent underutil inform intermedi layer forc generat focus salient region multi modal sourc imag furthermor phase model train add inform loss function adopt dual adversari structur enabl model captur detail qualit quantit experi public avail dataset valid propos method provid better visual result method retain detail inform | D007091;D000465 | T170;T066 |
36,261,764 | much move robust bias self rotat percept vestibular cue crucial sens linear angular acceler head three dimension space previous literatur show vestibular inform precoci combin sensori modal propriocept visual facilit spatial navig recent studi suggest auditori cue may improv self motion percept well present studi investig abil estim passiv rotat displac without virtual acoust landmark determin vestibular auditori inform interact process self motion inform perform two experi healthi particip sat rotat translat chair experienc yaw rotat along earth vertic axi perform self motion discrimin task goal estim clockwis counterclockwis rotat amplitud visual inform avail report whether felt rotat less accord condit vestibular audio vestibular inform present two experi manipul procedur present auditori cue passiv vs activ product sound comput point subject equal pse measur accuraci notic differ jnd precis estim condit direct rotat result experi show strong overestim bias rotat regardless condit direct sound generat condit similar previous found head bias bias rotat estim may facilit percept substanti deviat relev direct daili navig activ | D009039;D014722 | T023;T041 |
36,261,763 | test beat percept without sensori cue beat beat drop align test bdat beat percept serv window intern time keep mechan auditori motor interact aspect cognit one aspect beat percept covert continu intern puls sever popular test beat percept none provid satisfi test faculti covert continu current studi propos new beat percept test focus covert puls continu beat drop align test bdat test particip must identifi beat music excerpt judg whether singl probe fall beat probe occur short break rhythmic compon music rhythmic event present forc particip judg beat align relat intern puls maintain absenc local acoust time cue present two larg n test bdat first explor effect test item paramet eg probe displac perform second correl score adapt version bdat computer adapt beat align test ca bat score indic music experi music experi indic outperform ca bat score predictor bdat score suggest bdat measur distinct aspect beat percept experi depend may draw cognit resourc work memori music imageri differ bat bdat may prove use futur behavior neural research beat percept stimuli code freeli avail download | D003463;D009146 | T078;T170 |
36,261,755 | particl properti character data curat effect powder properti model pharmaceut industri comput model machin learn statist data analysi increas util mitig chemistri manufactur control failur relat particl properti solid dosag form manufactur advanc particl character techniqu comput approach provid unpreced opportun explor relationship particl morpholog drug product manufactur achiev howev numer challeng produc appropri curat robust particl size shape data address challeng requir harmon strategi materi sampl practic character techniqu select data curat provid data set inform materi properti herein common sourc error particl character data compress review propos provid robust particl morpholog size shape data support model effort approach data curat outlook model particl properti discuss | D066289;D004345 | T093;T066;T057 |
36,261,751 | vari outcom tripl negat breast cancer differ age group prognost valu clinic featur prolifer tripl negat breast cancer tnbc aggress diseas lack specif biomark guid treatment decis evalu combin prognost impact clinic featur novel biomark cell cycl progress age depend subgroup tnbc patient | D064726;D001943 | T191 |
36,261,750 | geoenvironment approach investig surfac groundwat pollut relat problem water sensit region desert environ clean dynam system due remot human intervent yet sometim approach anthropogen activ chang balanc ecosystem present studi state non plan construct wastewat plant affect environ led water resourc deterior present approach base integr hydrogeolog data togeth remot sens gis applic well statist chemic biochem bacteriolog analys water sampl groundwat show high salin valu mgl extract two coastal aquif middl miocen aquif repres main one pleistocen aquif limit use obtain result reveal exist pollut indic store rainwat groundwat coloni bacteria chemic biolog oxygen demand total organ carbon exceed permiss limit satellit imag acquir demonstr land use chang construct wastewat plant two forest led spread partial treat water marmarica plateau photogeolog lineament extract plateau affect mani fault ne sw nw se e w facilit surfac groundwat interact result indic studi groundwat becom vulner exist pollut sourc possibl affect climat chang saltwat intrus therefor integr approach present assess current environment problem suggest strategi mitig pollut hazard | D014874;D060587 | T081;T131;T070;T082 |
36,261,739 | improv patient monitor novel multisensori smartwatch applic design medic alarm heavili critic past decad auditori medic alarm poor learnabl discern relev lead poor patient outcom alarm fatigu overal poor informat system design develop novel trimod patient monitor smartwatch applic patient monitor particip complet two phase control novel trimod system identifi alarm heart rate oxygen blood pressur complet cognit demand task alarm auditori icon present either solo co alarm particip perform assess accuraci respons time rt alarm identif use novel system accuraci signific improv overal p co alarm situat p solo alarm p rt also signific faster p use novel system alarm type particip report decreas mental workload use novel system feasibl studi show novel alarm system perform better current standard improv accuraci rt perceiv mental workload indic potenti system posit impact medic informat system clinic monitor patient clinician | D056902 | T074 |
36,261,738 | seropreval camel brucellosi qatar brucellosi signific zoonot diseas one common neglect diseas worldwid infect wide rang domest wild anim speci infect anim usual cull caus substanti econom loss anim owner countri economi general diseas endem among cattl sheep goat mani countri around middl east preval gulf cooper council countri compris signific public health risk region studi investig seropreval brucellosi among camel qatar two hundr forti eight sampl collect dromedari camel farm across entir countri sampl test brucella antibodi rose bengal competit enzym link immunosorb assay sampl test posit test consid seroposit brucellosi overal preval ci associ sex seroposit slight signific p higher seropreval femal camel breed age ie year old show decreas seroposit ci compar ci seroposit camel year age signific associ age group seroposit p result indic seropreval brucellosi qatar camel alarm mandat effort control diseas find studi aid select better effect measur control camel brucellosi qatar studi need conduct brucella infect among camel determin predispos risk factor step follow control brucellosi | D002006;D002418;D015511 | T047 |
36,261,698 | fraction anisotropi peripher cytokin concentr outpati depress episod diffus tensor imag observ studi past year evid posit relationship inflamm depress grown steadili aim current studi investig whether depress relat inflamm could also associ alter microstructur chang white matter fa serum cytokin il il tnf ifn measur patient depress de healthi control hc diffus tensor imag perform fraction anisotropi fa calcul use fsl pipelin tract base spatial statist tbss voxelwis mean whole brain fa analyz use general linear model glm higher concentr il associ lower whole brain fraction anisotropi particular peopl depress p tnf share varianc il also show negat relationship tnf concentr fa depress f p p detail voxelwis analysi show regress slope il fa negat de group hc group main corpus callosum cluster statist genu corpus callosum p splenium corpus callosum p similar effect found remain cytokin studi clear demonstr associ peripher measur il white matter integr depress assess dti result suggest microstructur chang corpus callosum associ increas peripher il concentr depress | D056324;D016207 | T060;T129;T116 |
36,261,696 | women qualiti sleep vitro fertil success women undergo vitro fertil ivf emot challeng anxieti depress sleep disturb common complaint impact symptom ivf outcom howev debat studi aim investig whether sleep qualiti psycholog health affect chanc success procedur women undergo ivf recruit time oocyt retriev women sleep qualiti psycholog health assess use pittsburgh sleep qualiti index psqi fertil problem inventori fpi hospit anxieti depress scale had baselin characterist result three scale compar women succeed overal women includ clinic pregnanc expect success women younger ovarian reserv preserv fpi had score differ convers statist signific differ emerg psqi score median interquartil rang pregnant non pregnant women respect p crude adjust pregnanc women psqi indic impair sleep qualiti ci p ci p respect conclus low sleep qualiti common women schedul ivf could influenc success procedur | D000089943;D005307 | T033;T010;T061 |
36,261,691 | efficaci pace pharmacotherapi jhu lncap sm preclin model androgen independ prostat cancer prostat cancer pca complex diseas progress situ invas metastat tumor also capabl modul androgen depend understand novel therapi work across differ stage diseas critic proper posit spectrum pca treatment target proprotein convertas pace pair basic amino acid cleav enzym propos novel approach treat pca anim studi perform lncap xenograft androgen depend model alreadi yield posit result studi test pace inhibit jhu lncap sm newli describ androgen independ model cell base xenograft assay like lncap jhu lncap sm cell express pace oncogen isoform pace altct use isoform specif sirna downregul pace altct result jhu lncap sm growth inhibit furthermor jhu lncap sm respond pace pharmacolog inhibitor known c cell base assay well athym nude mice xenograft data support efficaci pace inhibitor androgen independ pca therebi demonstr pace key target pca jhu lncap sm cell line repres model featur import aspect androgen independ pca also repres conveni model oppos lncap cell vivo studi allow rapid screen due high implant rate growth characterist xenograft | D000728;D011471 | T125;T121;T039;T191 |
36,261,689 | earli onset sleepwak disturb progress macaqu model parkinson diseas parkinsonian patient often experi sleepwak disturb may appear earli stage diseas howev disturb fulli describ better understand evolut disturb respect diseas progress aim character clinic sign progress nonhuman primat model parkinson diseas three adult macaqu macaca fasciculari equip polysomnograph telemetri system allow character sleepwak behavior via long term neurophysiolog record underw modifi multipl sleep latenc test experi first perform healthi state progress induct parkinsonian syndrom intramuscular inject low dose mptp observ earli onset signific sleepwak disturb ie appear motor symptom disturb result disorgan nighttim sleep reduc deep sleep qualiti ii excess daytim sleepi character sleep episod occur rapid morn spread middl day present studi suggest nighttim daytim sleepwak disturb may appear earli diseas consid develop biomark studi | D010300;D012893 | T047;T048 |
36,261,687 | use hand grip strength estim physic fit paramet older adult studi aim reveal status physic fit pf level determin whether hand grip strength hgs could use estim pf paramet older adult larg popul data total particip age year particip nation fit award project south korea includ analysi particip highest level overal physic fit lowest level proport overal pf level differ signific accord age group signific associ hgs pf paramet chair stand test min min walk test sit reach test backward walk test figur walk test note group low hgs kg men kg women signific higher odd lowest level overal pf odd ratio men women adjust age bodi mass index hgs could estim muscular strength endur aerob fit flexibl balanc skill coordin skill well overal pf level older adult could use substitut test pf level limit situat | D018737;D010809 | T081;T078;T040 |
36,261,685 | optim annual bodi mass index chang prevent spontan preterm birth subsequ pregnanc preterm birth ptb lead caus neonat morbid mortal although ptb known recur interpregn prevent strategi ptb establish date annual bmi chang serv specif target valu prevent obstetr complic interpregn carecounsel valu also account age relat weight gain kgm year multicent retrospect studi investig optim annual bmi chang prevent ptb recurr use data individu two singleton birth associ annual bmi chang spontan ptb sptb analyz separ case medic indic ptb mptb sptb previous histori sptb strong associ sptb subsequ pregnanc adjust odd ratio aor confid interv ci increas annual bmi negat associ sptb aor ci sptb recurr rate signific lower patient annual bmi chang kgm year annual bmi chang kgm year vs p find suggest age relat annual bmi gain pregnanc may help prevent sptb recurr | D047928 | T046 |
36,261,683 | elk regul retin ganglion cell axon regener injuri adult central nervous system cns axon fail regener injuri master regul regen program remain identifi analyz transcriptom retin ganglion cell rgcs day optic nerv injuri without cocktail strong pro regen factor discov gene regul surviv regener use advanc bioinformat analysi identifi top transcript regul upstream gene cross referenc regul upstream gene differenti express embryon rgcs exhibit robust axon growth vs postnat rgcs potenti lost establish transcript activ elk top regul rgc gene express associ axon outgrowth model demonstr elk necessari suffici promot rgc neuroprotect regener vivo enhanc manipul specif phosphoryl site final co manipul elk pten rest anoth transcript factor discov analysi found elk downstream pten inhibit rest surviv axon regen pathway rgcs result uncov basic mechan regul surviv axon growth reveal novel potent therapeut strategi promot neuroprotect regener adult cns | D012165;D020221 | T025;T037 |
36,261,681 | associ iron status incid coronari arteri diseas popul base cohort studi disord iron metabol implic cardiovascular diseas howev associ serum iron store coronari arteri diseas cad remain inconsist investig associ serum iron metabol incid cad sever coronari arteri stenosi metabol biomark risk major advers cardiovascular event mace total cad patient healthi control enrol assess associ serum iron status presenc cad sever cad risk mace serum iron metabol metabol marker measur subject statist analys analyz use spss softwar stata statist packag serum level iron metabol marker includ serum iron unsatur transferrin iron bind capac uibc total iron bind capac tibc level cad group signific lower control group p uibc tibc negat correl ferritin sex unit increas serum iron tibc found protect role cad women iron ci tibc ci p howev high ferritin level signific associ cad incid sex ci men ci women p serum iron metabol marker exhibit signific associ sever cad increas serum level iron tibc level found protect role cad women men elev serum ferritin independ posit associ cad men women | D003324;D023921 | T047 |
36,261,680 | arlb control basal cell stem properti hedgehog signal mous epididymi epitheli cell orchestr seri intercellular signal event respons tissu damag epididymi compos pseudostratifi epithelium control acquisit male fertil mainten integr context tissu damag inflamm remain larg unknown basal cell epididymi contain primari cilium organell control cellular differenti respons hedgehog signal cue hypothes contribut epitheli homeostasi knock ciliari compon arlb keratin posit basal cell model reduc size basal cell primari cilia associ impair hedgehog signal loss krt krt p basal cell marker subject tissu injuri epididym epithelium knock mice display imbalanc rate cell proliferationapoptosi fail proper regener vivo respons associ chang transcriptom landscap relat immun respons cell differenti cell adhes trigger sever hypoplasia epithelium togeth result indic ciliari gtpase arlb particip transduct hedgehog signal pathway maintain basal cell stem need tissu regener find provid new insight role basal cell primari cilia safeguard pseudostratifi epithelia | D020727;D004822;D053823 | T123;T023;T126;T116 |
36,261,679 | associ egg consumpt blood pressur level glycat hemoglobin spanish adult accord bodi mass index object studi evalu associ egg consumpt blood pressur bp glycat hemoglobin hbac addit assess whether associ chang accord bodi weight status cross section studi base multicent data spanish adult particip evid ii trial egg consumpt assess food frequenc questionnair data bp hbac collect use standard procedur linear regress ancova model adjust main confound perform analys stratifi bodi weight status total particip analyz mean age year women compar lower consumpt higher egg consumpt associ lower systol p trend diastol p trend mean arteri pressur p trend lower hbac p trend level associ lost statist signific adjust analys result vari bodi weight status conclus consumpt egg per day associ bp hbac even overweight obes individu find suggest frequenc egg consumpt safe part healthi diet lifestyl cardiometabol risk | D006442 | T123;T116 |
36,261,678 | potenti clinic econom benefit remot deep brain stimul program deep brain stimul dbs teleprogram may help reduc travel relat financi burden patient maintain dbs care special situat determin travel relat burden dbs patient explor effect covid dbs care travel visit relat data patient retrospect analyz first year five year ten year initi dbs frequenc person telemedicin visit month period outbreak covid hungari also compar averag travel distanc person visit km averag travel time min travel cost first year five year ten year euro respect travel distanc age type sever diseas could help identifi patient would particular benefit teleprogram detect signific decreas number visit covid pandem p main result decreas frequenc person visit vs p result support introduct dbs teleprogram hungari could save money time patient maintain secur deliveri dbs | D046690;D000086382 | T061;T047;T067 |
36,261,675 | deep learn religi contin base toxic content detect classif time numer onlin communic platform emerg allow peopl express increas dissemin toxic languag racism sexual harass negat behavior accept polit societi result toxic languag identif onlin communic emerg critic applic natur languag process numer academ industri research recent research toxic languag identif use machin learn algorithm howev nontox comment includ particular identif descriptor muslim jewish white black assign unrealist high toxic rate sever machin learn model research analyz compar modern deep learn algorithm multilabel toxic comment classif explor two scenario first multilabel classif religi toxic comment second multilabel classif race toxic ethnic comment various word embed glove wordvec fasttext without word embed use ordinari embed layer experi show cnn model produc best result classifi multilabel toxic comment scenario compar outcom modern deep learn model perform term multilabel evalu metric | D000077321 | T066 |
36,261,674 | estim genet paramet growth trait direct matern effect murrah buffalo understand genet principl environment factor affect growth trait essenti implement optim breed select program earli growth indic futur success product reproduct status dairi anim studi total record bodi weight use estim genet paramet bodi weight birth bw month bw month bw month bw month bw month bw month bw month bw month bw murrah buffalo icar ndri karnal haryana period genet paramet estim use averag inform restrict maximum likelihood aireml procedur exclud includ matern effect six analyt model fit order optim model trait appropri univari model select base log likelihood ratio test lrt influenc factor like calf sex period birth season birth dam pariti investig result show matern genet effect addit direct addit effect import unbias accur genet paramet estim growth trait murrah buffalo total herit estim h bw bw bw bw bw bw bw bw bw respect matern effect signific birth weight account variat matern genet variabl matern perman environment effect matern genet effect also import trait howev interf estim varianc ratio live weight trait owe larg negat covari direct matern genet effect direct genet correl bodi weight trait posit high rang result reveal murrah herd sizabl genet variabl growth trait henc suffici scope select achiev better growth rate select direct appli owe higher posit genet correl bw later age scope indirect select optimum growth later age aim select anim higher month live weight | D000072741;D002020 | T045;T015 |
36,261,673 | action silicon activ antioxid enzym physiolog mechan mitig water deficit sugarcan energi cane plant product sugarcan recent energi cane strengthen renew bioenergi product capac howev drought result climat chang limit product crop one strategi attenu water deficit damag crop use silic contribut plant physiolog strategi like increas water use effici thus promot crop sustain notwithstand studi issu still incipi studi assess whether si appli via fertig foliar spray seedl product phase complement seedl transplant soil effici attenu water deficit sugarcan energi cane studi elucid physiolog biochem mechan involv process author conduct two experi one sugarcan energi cane treatment arrang random block replic factori scheme factor consist absenc si presenc si si appli via fertig foliar spray two water regim without water deficit sever water deficit soil water retent capac silicon suppli format phase presprout seedl transplant seedl pot fill sampl entisol quartzipsam pot water regim induc day transplant sever water deficit reduc water content water potenti plant situat induc oxid stress impair gas exchang photosynthet water use effici reduc plant growth silicon suppli via fertig associ foliar spray seedl format phase complement transplant effici increas si accumul plant silicon effect attenu sever water deficit damag initi culm format mechan maintain water physiolog balanc favor antioxid defens system sugarcan energi cane plant | D031786 | T002 |
36,261,671 | relationship blood pressur intraocular pressur jphc next eye studi although posit link hypertens intraocular pressur iop suggest individu effect systol diastol blood pressur sbp dbp respect iop remain unclear particular among japanes popul conduct larg scale cross section studi determin individu combin effect sbpdbp hypertens iop total japanes peopl age year underw system ophthalmolog examin includ measur blood pressur iop conduct use non contact tonomet adjust priori known confound factor sbp dbp level found posit correl iop level multivari adjust odd ratio compar hypertens normotens group preval ocular hypertens confid interv analys combin effect sbp dbp ocular hypertens sbp elev greater effect ocular hypertens dbp increas conclus sbp dbp level preval system hypertens found posit associ iop level preval ocular hypertens ophthalmolog healthi japanes popul find suggest system blood pressur control may key control iop | D009798;D006973 | T047 |
36,261,669 | waterbodi loss due urban expans larg chines citi last three decad urban waterbodi one pertin issu involv multipl aspect sustain develop goal sdgs howev waterbodi larg chines citi high vulner urban land expans most due econom develop popul growth rural urban migrat work select chines citi one million popul investig encroach waterbodi due rapid urban overal natur waterbodi area lost period urban expans fraction vari citi citi relat waterbodi abund acceler urban waterbodi occup becom serious p howev citi encroach eas sinc justifi effect implement nation scale polici conserv urban waterbodi meanwhil gain occur urban addit loss waterbodi especi citi lack waterbodi place greater emphasi ecolog factor whose urban waterbodi area show increas trend futur ecolog resourc includ waterbodi consid urban plan provid reason protect waterbodi quest urban sustain | D000075042;D014507 | T068;T083 |
36,261,667 | design structur spectral dft analyt studi novel nano palladium schiff base complex novel nano palladium ii schiff base complex c synthes reaction palladium chlorid schiff base n n phenylen bis aminobenzamid prepar compound character element analysi ultraviolet visibl spectroscopi uv vis fourier transform infrar spectroscopi ftir scan electron microscopi sem transmiss electron microscopi tem thermogravimetr analysi tga combin solvent sublat icp oe methodolog studi preconcentr separ determin trace palladium ii media divers origin use schiff base ligand differ experiment variabl affect sublat effici thorough investig viz ph sampl solut amount pd ii tbab type amount surfact type organ solvent temperatur stir time method involv determin trace palladium ii select separ solvent sublat thus elimin effect foreign ion increas sensit also palladium determin direct organ phase decreas determin time loss determin optimum condit linear rang pd ii ngml coeffici determin limit detect lod limit quantif loq ngl ngl respect sublat method appli real sampl recoveri obtain spike sampl preconcentr factor mechan solvent sublat tba pd ii ion pair discuss comput studi estim approv geometri isol solid compound | D012545;D013501 | T120;T122;T109 |
36,261,665 | low voltag drive high resist liquid crystal micro len electr tunabl depth field light field imag system light field imag lfi base liquid crystal microlen array lc mlas emerg signific area imag technolog field upcom internet thing artifici intellig era howev scene lfi convent mlas biolog imag medicin imag qualiti imag reconstruct sever reduc due limit depth field propos low voltag drive lc mlas electr tunabl depth field dof lfi system aluminum dope zinc oxid azo film deposit top hole pattern driven electrod array use high resist hi r layer uniform gradient electr field obtain across sandwich lc cell experiment result confirm propos lc mlas possess high qualiti interfer ring tunabl focal length lower work voltag addit focal length tunabl mm dof adjust mm experi demonstr lfi system base propos structur clear captur inform inset enlarg depth chang work voltag drive frequenc indic tunabl dof lc mlas potenti applic prospect biolog medic imag | D050866;D015034 | T104;T197;T121;T073 |
36,261,663 | prepar physicochem character bioactiv evalu berberin entrap albumin nanoparticl berberin bbr isoquinolin alkaloid sever clinic therapeut applic low water solubl absorpt cellular bioavail diminish bbr therapeut efficaci studi bbr encapsul bovin serum albumin nanoparticl bsa nps core reduc bbr limit enhanc clinic therapeut properti sever physicochem character tool dynam light scatter ultraviolet visibl spectroscop measur field emiss transmiss electron microscopi surfac morpholog fourier transform infrar spectroscopi thermal stabil analysi releas studi use evalu bbr bsa nps compar bbr bbr bsa nanoparticl demonstr superior free radic scaveng antioxid capac anti hemolyt anticoagul efficaci antimicrobi activ demonstr find vitro studi furthermor stress pancreat rat model induc use high fat high sucros diet plus carbon tetrachlorid inject vivo result reveal bbr bsa nps substanti restor peripher glucos metabol insulin sensit oral administr bbr bsa nps also improv pancreat cell homeostasi upregul pancreat antioxid mechan inhibit oxid generat attenu oxid injuri stress pancreat tissu conclus vitro vivo result confirm bbr bsa nps demonstr potent antioxid properti restor pancreat homeostasi compar bbr | D001599;D053758;D000890 | T121;T073;T109 |
36,261,660 | metabolit quantif fluoresc base method urin sampl normal prior h nmr analysi metabolom multi disciplin approach system biolog provid snapshot metabol status cell tissu organ metabolom use mass spectroscopi ms nuclear magnet reson nmr analyz biolog sampl low molecular weight metabolit | D055432;D014557 | T123;T091;T109 |
36,261,659 | molecular dope nucleic acid light emit crystal driven multisit intermolecular interact reveal fundament understand molecular dope dnas organ semiconduct tris hydroxyquinolin aluminum alq crystal vari type number purin pyrimidin constitut dna electrostat hydrogen bond stack interact alq dnas major factor affect molecular dope longer dnas induc higher degre dope due electrostat interact phosphat backbon alq among four base singl thymin base induc multisit interact stack hydrogen bond singl alq occur within probabl contrast singl adenin base form multisit interact within lower probabl two neighbor alq multisit interact facilit molecular dope alq particl compar cytosin guanin form stack thus photoluminesc optic waveguid phenomena crystal success tailor discoveri deepen fundament understand incorpor dnas organ semiconduct crystal | D013941;D009696 | T123;T114 |
36,261,657 | engin cell differenti sexual reproduct probiot mate yeast g protein coupl receptor gpcrs enabl cell sens environment cue indispens coordin vital process includ quorum sens prolifer sexual reproduct gpcrs compris largest class cell surfac receptor eukaryot three decad pheromon induc mate pathway baker yeast saccharomyc cerevisia serv model studi heterolog gpcrs hgpcrs report transcriptom profil follow mate pathway activ nativ hgpcr signal yeast use model guid approach correl gene express morpholog chang demonstr mate haploid cell arm hgpcrs endogen biosynthesi cognat ligand furthermor devis ligand free screen strategi hgpcr compat yeast mate pathway enabl hgpcr signal probiot yeast saccharomyc boulardii combin find enabl new mean studi mate hgpcr signal cell cell communic model eukaryot yeast probiot | D012441;D019936 | T007;T004 |
36,261,655 | reconstruct time shift hemodynam respons regress voxel time cours onto expect respons standard procedur function magnet reson imag reli exact onset time shape superimpos hemodynam respons function eleg captur time deviat time deriv regressor appear complic shape distort limit usual exploit reconstruct true time shift respons function togeth magnitud analysi time deriv approach provid close form function relat time shift regress coeffici allow hemodynam shift explain shape distort reconstruct behavior reliabl absolut latenc smaller best case experi confus latenc previous undiscuss shortcom current limit strategi may elimin correct latenc protect incorrect one | D006439;D008279 | T060;T170;T059;T042 |
36,261,651 | minimum data standard vector compet experi grow threat vector born diseas highlight recent epidem prompt increas focus fundament biolog vector virus interact end experi often reliabl way measur vector compet potenti arthropod vector transmit certain pathogen data experi critic understand outbreak risk despit collect report larg rang vector pathogen combin terminolog inconsist record scatter across studi accompani public often share data insuffici detail reus synthesi present minimum data metadata standard report result vector compet experi report checklist strike balanc complet labor intens goal make import experiment data easier find reus futur without much ad effort scientist generat data illustr standard provid exampl reproduc result studi aed aegypti vector compet zika virus | D000071243;D000071244;D000330 | T047;T005;T204 |
36,261,626 | spatial ecolog optim control game theoret fish problem paramount import ecolog system econom polici problem harvest natur resourc paradigmat situat question rais fish strategi inde overfish well known problem manag live stock greedi may lead overal dramat deplet popul harvest close relat topic nash equilibria context fish polici name two player competit pool resourc possibl find equilibrium situat goal paper provid detail analysi two queri ie optim fish strategi singl player model studi nash equilibria multipl player game use basic yet instruct mathemat model logist diffus equat framework under model simpli read formula see text k account natur resourc formula see text densiti popul harvest formula see text encod either singl player fish strategi deal nash equilibria combin fish strategi player articl consist two main part first one give fine characteris optimis singl player game one aim solv formula see text formula see text formula see text constraint fish strategi formula see text particular show depend valu constraint optim control problem may behav like convex convers concav problem also provid detail analysi larg diffus limit problem case two player involv rather write formula see text formula see text formula see text fish strategi th player also satisfi formula see text formula see text constraint defin formula see text aim find nash equilibrium prove exist nash equilibria sever differ regim investig sever relat qualit queri instanc provid exampl well known tragedi common studi complet varieti numer simul illustr result allow us formul open question conjectur | D005716;D065626 | T047;T170 |
36,261,625 | brachytherapi via depot biopolym bound synerg nanoparticl paclitaxel therapi resist pancreat tumour local advanc pancreat tumour high resist convent radiochemotherapi show resist surmount inject depot thermal respons elastin like polypeptid elp conjug iodin radionuclid elp combin system deliv nanoparticl albumin bound paclitaxel combin therapi induc complet tumour regress divers subcutan orthotop mous model locoregion pancreat tumour elp brachytherapi effect independ paclitaxel formul dose extern beam radiotherapi ebrt achiev tumour growth inhibit co administ nanoparticl paclitaxel histolog analys reveal elp brachytherapi led chang express intercellular collagen junction protein within tumour microenviron chang differ ebrt treat tumour correl improv deliveri accumul paclitaxel nanoparticl within tumour find support translat develop elp depot synergist treatment local pancreat cancer | D001918;D010190;D053758 | T061;T191;T073 |
36,261,623 | preserv patient privaci comput share electron health record data patient electron health record ehr contain valuabl clinic data use medic research public health inquir howev patient privaci regul improp resourc share risk limit access ehr medic data research public health purpos paper introduc end end secur solut address concern facilit share patient ehr data unsecur third parti server use level homomorph encrypt lhe scheme time test aggreg queri linear comput carri use hpe proliant dl gen server intel xeon platinum processor | D057286;D016494 | T078;T073;T080;T170;T097;T057 |
36,261,621 | new approach privaci preserv clinic decis support system hiv treatment hiv treatment prescript complex process clinic decis support system cdss categori health inform technolog assist clinician choos optim treatment base clinic trial expert knowledg usabl cdsss hiv treatment would signific improv use knowledg obtain treat patient knowledg howev main contain patient record whose usag restrict due privaci confidenti constraint | D020000;D015658 | T058;T170;T047 |
36,261,617 | integr transcriptom map regulatori network code long non code rnas provid genom resourc chickpea larg scale transcriptom analysi provid system level understand biolog process acceler function genom studi chickpea perform comprehens transcriptom analysi generat full length transcriptom express atlas protein code gene pcgs long non code rnas lncrnas differ tissuesorgan via deep sequenc high depth rna seq dataset reveal express dynam tissu specif along associ biolog function pcgs lncrnas develop coexpress network analysi reveal modul associ particular tissu set relat tissu compon transcript regulatori network trns includ transcript factor cognat cis regulatori motif target pcgslncrnas determin development program differ tissuesorgan identifi sever candid tissu specif abiot stress respons transcript associ quantit trait loci determin import agronom trait also identifi result provid import resourc advanc functionaltransl genom genet studi chickpea develop environment condit | D029863;D062085 | T168;T123;T002;T114 |
36,261,615 | fabric print head phantom use plaster mix polylact acid powder patient specif qa intens modul radiotherapi studi aim fabric heterogen phantom replic commerci rando phantom mix plaster powder polylact acid pla powder produc heterogen phantom use plaster pla cheaper easili obtain commerci market addit patient specif qualiti assur easili perform phantom produc base patient ct imag pla well studi field radiat therapi found safe effect match mean hounsfield unit hu valu rando phantom bone tissu chang use plaster pla powder appropri hu valu obtain soft tissu chang use pla infil valu appropri hu valu obtain bone tissu hu higher soft issu hu air caviti less hu model base hu valu comput tomographi ct imag bone tissu model caviti three dimension print solut contain mixtur plaster pla powder pour evalu bone implement phantom obtain mixtur plaster pla powder hu profil ct imag print phantom use pla rando phantom print use pla evalu mean hu valu soft tissu rando phantom hu show greatest similar result obtain infil valu hu mean hu valu bone tissu hu show greatest similar valu obtain pla powder hu thus phantom compos plaster mix pla powder soft tissu fabric use printer infil valu bone tissu fabric mixtur contain pla powder hu profil phantom show mean differ hu soft tissu hu bone tissu comparison rando phantom ratio pla powder plaster adjust achiev hu valu similar bone tissu simpl combin pla powder plaster enabl creation custom phantom show similar rando phantom soft tissu bone tissu | D050397 | T061 |
36,261,609 | factor impact length hospitalis death rate covid patient base initi triag use capillari blood gas test singl centr studi import element effect treatment patient infect sar cov virus pandem effect earli triag determin patient alloc patient therapi paper assess prognost valu capillari blood gas test predict extend hospitalis death due covid retrospect statist research base group patient hospitalis octob march studi utilis treatment document patient hospitalis due covid pulmonolog thorac surgeri centr bystra southern poland period hospit bed access oxygen covid patient five bed intens care unit basi obtain result conclus drawn need earli oxygen therapi oxygen mask low ph valu capillari blood signific risk factor prolong hospitalis due covid age need earli oxygen mask therapi low oxygen satur import risk factor death covid capillari blood gas analysi simpl effect method earli patient segreg covid patient | D000086382 | T047;T067 |
36,261,606 | fatti acyl coa reductas influenc wax biosynthesi cotton mealybug phenacoccus solenopsi tinsley mealybug high aggress divers plant waxi layer cover outermost part integu import protect defens pest howev molecular mechan under wax biosynthesi mealybug remain larg unknown analyz multi omic data wax biosynthesi cotton mealybug phenacoccus solenopsi tinsley found fatti acyl coa reductas psfar gene high express fat bodi femal mealybug contribut wax biosynthesi regul product domin chemic compon wax cuticular hydrocarbon chcs rna interfer rnai psfar dsrna microinject allow mealybug feed transgen tobacco express target dsrna result reduct chc content waxi layer increas mealybug mortal desicc deltamethrin treatment conclus psfar play crucial role wax biosynthesi mealybug therebi contribut adapt water loss insecticid stress | D007306;D006430 | T131;T204 |
36,261,605 | relationship liver fat content lifestyl factor adult metabol syndrom aim studi investig associ liver fat content lfc sedentari behaviour sb physic activ pa fit diet bodi composit cardiometabol risk factor adult metabol syndrom total sedentari adult mean age sd year women overweight obes particip lfc assess magnet reson spectroscopi imag sb pa hip worn acceleromet sd day fit maxim bicycl ergometri bodi composit air displac plethysmographi nutrient intak day food diari lfc independ associ sb pa fit adjust sex age lfc associ bodi fat bodi mass index waist circumfer triglycerid alanin aminotransferas insulin resist marker invers associ lfc daili protein intak persist adjus bodi fat lfc posit associ bodi adipos cardiometabol risk factor invers daili protein intak sb habitu pa fit independ modul lfc howev pa essenti compon healthi lifestyl may contribut liver health indirect effect bodi composit adult metabol syndrom | D024821 | T047 |
36,261,604 | epidemiolog acut gastroenter franc novemb august light report adher covid barrier measur sinc start covid pandem french health author encourag barrier measur implement three lockdown slow sar cov transmiss aim examin impact measur epidemiolog acut gastroenter age franc novemb august describ trend age indic syndrom surveil sentinel surveil network addit describ report age ill data communiti base cohort frequenc adher covid barrier measur repeat quantit survey week age indic reach lowest level observ sinc last decad first lockdown median incid rate report sentinel network per inhabit time lower minimum regist period low activ persist april report ill communiti cohort mirror trend adher covid barrier measur highest first lockdown coincid steep decreas age incid among children year age incid increas third lockdown june juli remain lower previous winter season peak studi indic reduct adher covid barrier measur end lockdown coincid increas age incid particular among young children therefor strong recommend maintain adher barrier measur order order limit transmiss age relat pathogen | D000086382;D005759 | T047;T067 |
36,261,601 | multi physic uncertainti quantif use physic base machin learn quantit predict physic state earth subsurfac routin base numer solut complex coupl partial differenti equat togeth estim uncertainti materi paramet result high dimension problem comput prohibit even state art solver solut studi introduc hybrid physic base machin learn techniqu non intrus reduc basi method construct reliabl scalabl interpret surrog model approach combin physic process model data driven machin learn techniqu allow us overcom limit specif individu compon enabl us carri probabilist analys global sensit studi uncertainti quantif real case non linear coupl physic problem addit provid order magnitud comput gain maintain accuraci higher measur error although studi use thermo hydro mechan reservoir applic illustr featur theori describ equal valid applic wider rang geoscientif applic | D000069550;D010825 | T090;T066 |
36,261,600 | peripher cell cytotox predict efficaci anti pd therapi advanc non small cell lung cancer patient anti program cell death pd therapi exert benefici effect limit popul cancer patient therefor accur diagnost predict efficaci anti pd therapi desir present studi investig whether peripher cell cytotox predict efficaci anti pd therapi advanc non small cell lung cancer nsclc patient advanc nsclc patient treat anti pd monotherapi nivolumab pembrolizumab consecut enrol present studi peripher blood sampl subject analysi peripher cell cytotox flow cytometri prior initi anti pd therapi peripher cell cytotox assess use bispecif cell engag bite technolog found progress free surviv signific longer patient high peripher cell cytotox p multivari analysi treatment line peripher cell cytotox independ prognost factor progress free surviv analysi cell profil reveal peripher cell cytotox correl ratio effector memori popul cd cd cell furthermor result flow cytometri show peripher cdracdcd cell ratio higher patient without sever advers event p result indic peripher cell cytotox predict efficaci anti pd therapi advanc nsclc patient | D002289;D008175 | T191 |
36,261,598 | reduc neural respons reward reflect anhedonia inattent erp studi inhibit neural respons reward typic clinic depress predict individu overal depress symptom howev mechan under unclear previous studi found anhedonia inattent may mediat relationship reward sensit depress symptom therefor studi aim verifi relationship reward sensit overal depress symptom depress tendenc sampl well explor mechan under abil neural respons reward predict overal depress symptom via mediat model sixti four particip depress tendenc without dichotom bdi ii finish simpl gambl task event relat potenti compon erp record compar linear regress conduct verifi predict effect erp overal depress symptom multipl mediat model use anhedonia distract mediat reward sensit overal depress symptom amplitud reward posit rewp greater healthi control compar depress tendenc p gain lock erp compon b p rewp b p could signific negat predict overal depress symptom even control anxieti symptom indirect effect anhedonia distract signific confid interv contain direct effect reward sensit depress symptom signific lower confid interv upper confid interv individu depress tendenc display impair neural respons reward compar healthi control reduc individu neural respons reward may reflect differ biotyp depress anhedonia inattent | D003865;D005715 | T055;T048 |
36,261,594 | salivari cortisol level stress adult profound intellectu multipl disabl particip structur water danc intervent randomis control crossov trial structur water danc intervent swan danc orient aquat group activ direct give opportun joy movement relax reduc stress studi aim evalu effect swan salivari cortisol stress adult profound intellectu multipl disabl pimd total adult pimd four habilit centr sweden complet swan intervent intervent administ min week week period saliva cortisol collect morn even baselin one week intervent thrice intervent period one week intervent moreov connect swan session particip level stress also assess accompani assist result show salivari cortisol particip stress decreas signific direct swan session compar measur direct session studi demonstr adult pimd diurnal salivari cortisol pattern consist observ adult without disabl swan reduc salivari cortisol level stress peopl pimd justifi swan could consid choic intervent reduc stress adult pimdtrial registr studi regist clinicaltrialsgov id nct | D003615;D008607 | T056;T048 |
36,261,592 | clinician prefer instrument variabl analysi effect magnesium supplement atrial fibril prophylaxi critic care atrial fibril frequent encount condit critic ill caus advers effect includ haemodynam decompens stroke prolong hospit stay common practic critic care supplement serum magnesium purpos prevent episod atrial fibril howev randomis studi support practic non cardiac surgeri critic care popul effect magnesium supplement unclear sought investig effect magnesium supplement prevent onset atrial fibril mix critic care popul conduct singl centr retrospect observ studi adult critic care patient utilis natur experi design use supplement prefer bedsid critic care nurs instrument variabl use routin collect electron patient data magnesium supplement opportun defin link bedsid nurs nurs prefer administ magnesium obtain use multilevel model result use defin liber restrict supplement group input instrument variabl regress obtain estim effect magnesium supplement magnesium supplement opportun analys repres critic care admiss patient signific variat magnesium supplement practic attribut individu nurs account covari instrument variabl analysi show magnesium supplement associ decreas relat risk experienc atrial fibril event ci p studi support strategi routin supplement work requir identifi optim serum magnesium target atrial fibril prophylaxi | D001281 | T047;T046 |
36,261,589 | thermal enhanc numer solut blood nanofluid flow stenot arteri blood flow stenot arteri one import research area comput fluid mechan due applic biomedicin aim research work investig impact nanoparticl characterist human blood flow stenos blood arteri consider problem newtonian fluid assum human blood newtonian fluid flow larg blood vessel constitut equat togeth boundari condit diminish non dimension form use boundari layer approxim similar transfigur attain solut veloc temperatur distribut blood flow arteri stenosi numer help matlab bvpc result physic quantiti cylindr surfac calcul effect also present tabl heat transfer rate increas throughout stenos arteri concentr copper nanoparticl veloc curv decreas increas valu flow paramet nanoparticl volum fraction temperatur curv increas due increas valu nanoparticl volum fraction decreas prandtl number | D003300;D053758 | T123;T196;T121;T073 |
36,261,587 | retrospect cohort studi compar differ day mortal among critic ill patient age year treat european tax base healthcar system ths versus social health insur system europ tax base healthcar system ths social health insur system shi coexist examin differ day mortal among critic ill patient age year treat intens care unit ths shi retrospect cohort studi ths n shi n critic ill year patient icus general estim equat robust standard error chosen creat popul averag adjust odd ratio aor data adjust patient specif variabl organ support health econom data primari outcom day mortal numer differ shi ths sofa score vs p observ clinic frailti score similar vs p higher rate renal replac therapi vs p found shi aor ci p differ regard intub rate vs p vasopressor use vs p day mortal rate vs p found mortal remain similar system multivari adjust sensit analys retrospect charact studi baselin risk mortal rate similar shi ths type health care system appear play role intens care treatment critic ill patient year covid europ | D016638;D000086382 | T047;T067 |
36,261,581 | predict mortal old machin learn analysi claim data machin learn ml may use predict mortal use claim data one larg german insur develop test differ complex ml predict model compar balanc accuraci also import differ predictor relev follow period death ie amount accumul data time distanc data use predict death sampl insur old age year live northeast germani drawn follow year outcom whether individu die one year interest primari metric balanc accuraci hold test dataset potenti variabl use import one model train total model combin three differ ml model use logist regress lr random forest rf extrem gradient boost xgb differ period follow employ train year differ time distanc data use predict time event deathsurviv set year mortal rate mean per year model show balanc accuraci longer follow period show limit advantag model short time distanc event accur model train distant data rf xgb accur lr rf xgb sensit specif similar lr sensit signific lower specif three model posit predict valu even drop longer time distanc death negat predict valu signific exceed analys util cost emerg transport well emerg hospit visit well util convent outpati care laboratori servic consist found relev predict mortal model show use accuraci complex model show advantag variabl employ predict consist across model medic reason identifi individu risk could assist tailor decis make intervent | D000069550 | T066 |
36,261,579 | iron sulfur cluster essenti dna bind human dna polymeras dna polymeras pol key enzym dna replic eukaryot recent shown catalyt domain yeast pol pol cd contain fe cluster locat base process domain p domain coordin four conserv cystein work show human pol cd hpol cd express bacteri cell also contain iron sulfur cluster comparison recombin hpol cd produc insect cell contain signific lower level iron iron content purifi hpole cd sampl correl level dna bind molecul suggest import role iron sulfur cluster hpol interact dna inde mutat two conserv cystein coordin cluster abolish templat primer bind well dna polymeras proofread exonucleas activ propos cluster regul conform p domain like gatekeep control access dna bind cleft templat primer bind studi demonstr low affin hpol cd dna strong effect salt concentr stabil hpol cd dna complex pre steadi state kinet studi shown maxim polymer rate constant relat low affin incom dntp appar k | D004257;D007506 | T123;T126;T116 |
36,261,577 | autotox ambrosia artemisiifolia ambrosia trifida signific regul intraspecif popul densiti ambrosia artemisiifolia ambrosia trifida annual invas plant caus serious harm agricultur anim husbandri human health base import characterist high densiti cluster distribut popul specul autotoxin effect densiti regul studi explor regul autotox intraspecif densiti use water extract two plant compar verifi autotox seed germin analys compon autotoxin result show artemisiifolia trifida signific autotox highest inhibit rate seed germin respect ultra perform liquid chromatographi tandem mass spectrometri analysi reveal chlorogen acid caffeic acid p coumar acid vanillin main autotoxin two plant seed wash water germin recoveri rate seed increas increas inhibit degre autotoxin treatment therefor studi verifi autotox artemisiifolia trifida promot inhibit seed germin artemisiifolia trifida regul intraspecif competit | D031164;D002726 | T123;T002;T109 |
36,261,574 | adapt tensor decomposit pca base unsupervis featur extract select biolog reason differenti express gene convent method tensor decomposit princip compon analysi base unsupervis featur extract propos almost year ago respect although method success appli wide rang genom analys includ drug reposit biomark identif diseas caus gene identif fundament problem identifi number gene identifi small assum fals negat histogram p valu deriv fulli coincid null hypothesi princip compon singular valu vector follow gaussian distribut optim standard deviat histogram p valu much possibl coincid null hypothesi result increas number biolog reliabl select gene contribut improv method abl select biolog reason differenti express gene state art method must empir assum negat binomi distribut dispers relat requir select express gene less express one achiev propos method assum | D000465 | T170 |
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