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36,261,243
learn curv associ pathologist perform diagnost accuraci linear endobronchi ultrasound transbronchi needl aspir ebus tbna cohort studi tertiari care refer centr aim assess learn curv influenc pathologist perform endobronchi ultrasound transbronchi needl aspir ebus tbna diagnost accuraci real world studi
D059032;D009369
T191;T041
36,261,242
protocol multicentr prospect observ studi famili full term infant postnat ward communiti captur feed practic across first year life mother infant lactat questionnair milq studi breastmilk consid gold standard infant nutrit breast feed recommend sole sourc nutrit birth around month age continu beyond age complementari food introduc breast feed initi general high develop countri continu breast feed appear drop rapid prospect observ studi life aim characteris current pictur infant feed practic across first year motiv feed practic identifi barrier enabl breast feed
D001942;D009035
T055;T092;T040;T099;T058
36,261,241
relationship job satisfact burnout syndrom depress symptom physician cross section studi base employ demand control model use structur equat model evalu relationship job satisfact burnout syndrom bs depress symptom ds base job demand control framework model nation repres sampl physician work peruvian health system
D007588;D002055
T041;T048
36,261,240
choic partnership approach communiti mental health addict servic realist inform scope review choic partnership approach capa develop creat access child centr famili centr model child adolesc mental health servic deliveri adapt differ set sought describ state evid regard extent outcom contextu consider capa implement communiti mental health servic
D008603;D008605
T058;T041
36,261,239
hospit frailti risk score hfrs appli primari data protocol systemat review frailti characteris vulner advers health outcom increas age mani frailti risk score develop one import exampl hospit frailti risk score hfrs potenti wide use automat calcul provid accur assess frailti timecost effect manner systemat review therefor seek describ hfrs use sinc public
D000073496;D006480
T033;T184;T047;T046
36,261,238
cohort profil south african nation health laboratori servic nhls nation hiv cohort south africa nation health laboratori servic nhls nation hiv cohort establish facilit monitor evalu research south africa nation hiv treatment programm south africa peopl live hiv know hiv status know status art art virolog suppress
D015658;D019380
T121;T047
36,261,237
associ recoveryoccurr metabol syndrom rapid estim glomerular filtrat rate declin middl age older popul evid china health retir longitudin studi studi explor correl metabol syndrom met alter renal deterior longitudin cohort aim investig associ met recoverydevelop rapid estim glomerular filtrat rate egfr declin china health retir longitudin studi charl
D024821;D051436
T047
36,261,236
mediat role work motiv job satisfact work relat basic need satisfact work engag among doctor china cross section studi studi aim examin associ work relat basic need satisfact w bns doctor work engag explor mediat role work motiv job satisfact two variabl
D007588;D000074824
T041;T057
36,261,235
predict valu tachycardia mortal trauma relat haemorrhag shock systemat review meta regress heart rate hr one physiolog variabl earli assess trauma relat haemorrhag shock accord advanc trauma life support atl howev effici predictor mortal contradict sever studi furthermor linear associ hr sever shock blood loss present atl doubt systemat review aim updat current knowledg role hr initi haemodynam assess patient trauma
D012771
T046
36,261,234
characteris methamphetamin use inform health social polici manitoba canada protocol retrospect cohort studi use link administr data rise use methamphetamin caus signific public health concern canada biolog behaviour effect methamphetamin rang wake vigour euphoria advers physic health outcom like myocardi infarct haemorrhag stroke arrhythmia seizur also caus sever psycholog complic psychosi nation survey data point increas rate methamphetamin use well increas eas access serious methamphetamin relat harm urgent need evid address knowledg gap provid direct harm reduct treatment effort inform health social polici peopl use methamphetamin protocol describ studi aim address need evid
D008694
T121;T131;T109
36,261,231
associ socioeconom status mucos heal japanes patient ulcer coliti cross section studi socioeconom status risk factor wors outcom mani diseas howev evid associ socioeconom status clinic outcom patient ulcer coliti uc limit clinic set therapeut goal uc achiev mucos heal mh thus aim studi examin associ socioeconom status mh patient uc
D003093
T047
36,261,230
tuberculosi diagnosi manag public versus privat sector standardis patient studi mumbai india rigor studi compar qualiti tuberculosi tb care public versus privat sector
D017149;D014376
T047;T098;T057
36,261,229
twelv month observ studi children cancer countri covid pandem childhood cancer lead caus death unclear whether covid pandem impact childhood cancer mortal studi aim establish caus mortal rate childhood cancer covid pandem determin factor associ mortal
D000086382;D009369
T047;T191;T067
36,261,228
predict model covid liver dysfunct patient normal hepat biochem paramet coronavirus diseas covid patient liver dysfunct ld higher chanc develop sever critic diseas routin hepat biochem paramet alt ast ggt tbil limit reflect covid relat ld studi perform proteom analysi serum sampl covid patient identifi new biomark ld establish simpl machin learn model use proteom measur clinic variabl predict ld develop cohort covid patient normal hepat biochem paramet model base biomark angl sex exhibit best discrimin time depend auc calibr net benefit develop cohort accuraci model independ cohort model exhibit great potenti support optim therapeut strategi covid patient high risk ld model public avail https xixihospit liufangshinyappsiodynnomapp
D000086382;D008107
T033;T047;T067
36,261,227
replic associ invers domin form bacteri chromosom structur variat structur arrang bacteri chromosom vari wide close relat speci result signific phenotyp outcom appear larg scale chromosom invers symmetr relat marker origin replic oric previous observ howev overal preval replic associ structur rearrang rasr bacteria causal mechan current unknown systemat identifi locat rasr speci multipl complet sequenc genom investig potenti mediat biolog mechan found speci contain sequenc least one larg kb invers sequenc comparison aggreg invers distanc away symmetri normal distribut mean zero mani invers offset dnaa found center differ marker oric instanc flank repeat provid evid break form replic process could repair oppos posit also found strong relationship later stage replic rang distanc variat symmetri
D018741;D002876
T026;T086
36,261,226
tandem repeat nbpf hor copi olduvai triplet possibl impact human brain evolut previous found neuroblastoma breakpoint famili nbpf gene repeat unit kb import role human brain evolut function higher order organ repeat unit discov method higher order repeat hor search method hls search method use hor search method global repeat map algorithm identifi tandem organ nbpf hor human nonhuman primat ncbi refer genom identifi tandem organ canon mer nbpf hor copi olduvai triplet none nonhuman primat chimpanze gorilla orangutan rhesus macaqu discontinu jump tandem organ hor copi number sharp contrast known gradual increas number olduvai domain nbpf monom nonhuman primat human especi chimpanze human genom use global repeat map algorithm method also determin mer tandem canon mer hor copi random chosen human genom male femal case found mer hor copi number case refer human genom mutat hand point mutat respect refer genom found nbpf monom tandem organ canon hor
D002679;D009447
T015;T191
36,261,224
acut compart syndrom contralater thigh follow reconstruct shoulder surgeri done multidirect shoulder instabl later decubitus posit man earli revis reconstruct surgeri left shoulder right later decubitus posit prolong surgeri hour caus acut compart syndrom ac contralater right thigh moder pain swell contralater thigh well limb first note recoveri room progress sever swell numb right toe fasciotomi right thigh perform confirm ac thirteen month later return prior work without lower extrem discomfort limit report good result revis shoulder surgeri non traumat ac well limb rare complic surgeri perform later decubitus posit suggest move patient temporarili new posit eg beach chair consid durat surgeri approach hour
D012785;D007593;D003161;D019651
T061;T030;T033;T023;T047
36,261,222
spontan intraperiton haemorrhag gastric vessel male present emerg depart sudden onset abdomin pain syncop emerg depart develop worsen hypotens anaemia ct angiogram suggest abdomin apoplexi spontan intraperiton haemorrhag treat success embolis bleed vessel spontan bleed thought relat initi apixaban week previous patient made excel recoveri transit back oral anticoagul
D006465;D015746
T184;T046
36,261,221
cervic thorac duct cyst conserv resolut woman present enlarg asymptomat palpabl mass left supraclavicular fossa clinic impress lipoma imag show cystic lesion continu tubular structur lead carotid sheath cytolog consist thorac duct sampl diagnosi rare entiti thorac duct cyst supraclavicular extens made manag conserv via repeat aspir reduc size mass
D013897;D008476
T023;T191;T047
36,261,220
primari mucin cell adenocarcinoma femal urethra primari adenocarcinoma femal urethra rare entiti incid increas age highest rate women age year adenocarcinoma urethra common among women men associ relat poor prognosi report case primari adenocarcinoma urethra review literatur emphasi diagnosi manag outcom rare tumour
D014523;D002288;D000230
T191
36,261,219
anatom challeng rare coexist caecal cancer isol duoden malrot intestin malrot congenit anomali treat most childhood small number case incident found adulthood oper abdomin diseas colon cancerher present case caecal cancer isol duoden malrot subtyp intestin malrot discov incident oper cancer although anatom abnorm made oper complic laparoscop resect safe perform oncolog adequ lymphadenectomi owe intraop confirm anatomi care dissect
D002430;D010535;D003110
T060;T191;T061
36,261,218
artifici intellig enabl phenotyp patient sever aortic stenosi recoveri extra aortic valv cardiac damag transcathet aortic valv replac novel artifici intellig base phenotyp approach stratifi patient sever aortic stenosi prior transcathet aortic valv replac tavr propos base echocardiograph haemodynam data studi aim analys recoveri extra aortic valv cardiac damag accord novel stratif system follow tavr
D065467;D001024
T061;T047
36,261,217
virtual librari behavior perform standard condit rodent spontan activ open field repeat test treatment drug brain lesion beyond specif experi video record behavior futur valu exampl input new experi yet unknown type analysi behavior similar tissu blood sampl bank life scienc clinic deriv otherwis well describ experiment sampl store avail unknown potenti futur purpos
D012377;D009771
T015;T048
36,261,215
intraderm vaccin hpv e synthet peptid conjug optim toll like receptor ligand show safeti potent cell immunogen patient hpv posit pre malign lesion ampliv molecular optim toll like receptor ligand coval conjug tumor peptid antigen preclin model ampliv adjuv synthet long peptid slps strong enhanc antigen present dendrit cell cell prime induct effect antitumor respons current studi first human trial investig safeti immunogen ampliv conjug human papillomavirus hpv slp
D052162;D002583;D053918;D030361
T121;T129;T116;T191;T005;T047
36,261,213
address childcar barrier healthcar access communiti partnership larg public health system public health system survey reproduct age women identifi lack childcar common reason miss delay healthcar communiti base organis cbos counti identifi similar need partner develop hospit base childcar centr patient use appoint
D006176;D009774
T091
36,261,212
status patient safeti select ghanaian hospit nation cross section studi safeti one dimens healthcar qualiti core achiev univers health coverag healthcar deliveri worldwid ghana status patient safeti last year remain unknown therefor studi aim assess patient safeti status select hospit ghana
D061214;D006761
T058;T073;T093
36,261,211
post covid pulmonari mass case report review literatur present unusu rare pulmonari affect coronavirus diseas covid one lung affect coronavirus diseas attack lung interfer serious function attack usual bilater uni later pulmonari affect unusu present clinic radiolog find bronchoscopi appear strang oper find resect mass unev post oper cours addit histopatholog report presentedin conclus unilater lung affect unusu post viral pneumonia covid consid possibl aftermath may uncommon iraq
D000086382;D011024
T047;T067
36,261,210
evalu diaphragm thick predict intub requir mortal critic covid patient investig valu measur diaphragm thick dt thorax comput tomographi ct intens care unit icu admiss predict intub requir mortal among covid patient
D000086382
T047;T067
36,261,209
correl plasma glutathion peroxidas n acetylneuramin acid level clinic risk stratif prognosi patient acut coronari syndrom investig correl plasma glutathion peroxidas gpx n acetyl neuramin acid neuac clinic risk stratif outcom acut coronari syndrom ac patient
D054058
T047
36,261,208
preval predict factor infertil relat stress among infertil coupl cross section studi jordan occupi palestinian territori assess level infertil relat stress associ socio econom demograph factor among infertil coupl live jordan live chronic isra palestinian conflict occupi palestinian territori
D018912;D007246
T033;T098;T046
36,261,207
preval perian diseas associ factor primigravida women hospit base cross section studi defin incid anorect diseas primigravida women well first month deliveri factor affect develop anorect diseas
D003248;D012002
T184;T047
36,261,206
self esteem mediat relationship perceiv stigma self efficaci diabet manag individu type diabet mellitus determin mediat effect self esteem relationship perceiv stigmat individu type diabet mellitus tdm self efficaci regard diabet manag
D020377;D003924
T047;T041
36,261,205
risk factor earli postop cardiac arrhythmia pediatr cardiac surgeri singl center experi evalu incid arrhythmia earli postop period identifi risk factor among pediatr patient follow cardiac surgeri king abdulaziz univers hospit kauh jeddah saudi arabia
D006348;D006330
T061;T019
36,261,204
molecular character helicobact pylori clinic isol eastern saudi arabia describ frequenc cytotoxin associ gene caga vacuol cytotoxin vaca virul gene clarithromycin resist associ mutat among helicobact pylori h pylori clinic isol eastern saudi arabia
D016480;D016481
T047;T007
36,261,202
analges effect dexmedetomidin colorect cancer patient undergo laparoscop surgeri evalu analges efficaci intraop dexmedetomidin dex acut postop pain colorect cancer patient undergo laparoscop surgeri
D020927;D018712;D010535;D015179
T061;T121;T109;T060;T191
36,261,201
testi specif protein encod regul androgen receptor express mapkerk pathway male hepatocellular carcinoma analyz mechan testi specif protein encod tspi male hepatocellular carcinoma hcc
D006528;D008113
T191
36,261,200
investig analges efficaci ultrasound guid thoracolumbar interfaci plane block vertebr surgeri prospect random clinic studi investig effect thoracolumbar interfaci plane block tlip analges consumpt pain score vertebr surgeri
D009407;D014147
T061;T121;T109
36,261,198
combin stellat ganglion block intraven region anesthesia treat complex region pain syndrom year experi tertiari center studi reduct pain score treatment intraven region anesthesia ivra stellat ganglion block sgb combin complex region pain syndrom cprs patient quantifi patient satisfact treatment occurr complic
D000765;D020918;D012019
T061;T047
36,261,194
adipos deriv mesenchym stem cell wound heal potenti clinic applic wound repair delay chronic wound result dysregul molecular cellular event associ wound heal includ migrat inflamm angiogenesi extracellular matrix ecm remodel epitheli adipos tissu abund easili access rich sourc mesenchym stem cell mscs high therapeut potenti addit capabl differenti various lineag special function adipos deriv mscs amsc mediat wound repair process secret differ growth factor mediat rather make structur contribut alon adipos deriv mscs mediat format blood vessel recruit progenitor cell stimul cell differenti ecm format promot wound heal releas immun mediat exosom herein discuss review therapeut potenti amsc wound repair via acceler wound closur epitheli enhanc angiogenesi immunomodul prolong inflammatori respons well current challeng clinic implement
D059630
T025
36,261,193
sphingosin kinas act hypoxia upregul oncogen regul cell invas resist nk cell kill bladder carcinoma cell hypoxia facilit aggress phenotyp immun evas solid tumor includ bladder cancer bc sphingosin kinas sphk aberr express correl poor prognosi bc patient howev role hypoxia evok malign immun evas bc remain elus
D001749;D002277
T191
36,261,192
surveil sar cov antibodi earli among rhode island pregnanc limit data avail perform sar cov antibodi assay data collect pregnanc vari wide object studi estim seropreval antibodi sar cov pregnant individu rhode island evalu whether preval differ month collect age counti resid econom status estim zip code
D000086402;D000086382
T005;T067;T047
36,261,191
knockdown batf inhibit gastric cancer cell growth radioresist via sprstat pathway gastric cancer one common dead cancer worldwid basic leucin zipper transcript factor atf like batf play key role tumor immun howev function batf gastric cancer remain unclear demonstr batf posit regul prolifer radioresist gastric cancer cell regul sprstat pathway
D013274
T191
36,261,190
updat correl fentanyl posit drug screen medic patient pain rehabilit behavior program monitor fentanyl polydrug use past six year
D013287;D008694;D019966
T121;T109;T131;T033;T048
36,261,189
first case adult granular acut lymphoblast leukemia dnmta mutat monosomi granular acut lymphoblast leukemia defin presenc intracytoplasm granul lymphoblast blast mimick acut myeloblast leukemia diseas extrem rare adult henc characterist thereof poor understood report case year old man diagnos granular bone marrow examin show blast azurophil granul cytoplasm immunophenotyp show b aberr express myeloid antigen cd cd karyotyp reveal monosomi target ngs show dnmta mutat suggest poor prognosi despit convent chemotherapi treatment patient achiev complet remiss declin chemotherapi treatment maintain support care first report adult granular dnmta mutat monosomi
D054198;D015470
T191
36,261,188
downregul slca express indic poor prognosi promot progress non small cell lung cancer solut carrier slc gene known involv develop human tumor identifi group non small cell lung cancer nsclc associ slc gene explor role potenti mechan action slca nsclc
D002289;D008175
T191
36,261,187
infliximab effect pediatr patient ulcer coliti primari failur adalimumab fda approv adalimumab anti tumor necrosi factor alpha agent treatment moder sever pediatr ulcer coliti uc februari real world public howev adalimumab first line biolog pediatr uc form chronic inflammatori bowel diseas ibd
D003093;D001688
T123;T047;T121
36,261,186
foxj inhibit prolifer migrat epitheli mesenchym transit prostat carcinoma cell forkhead box j foxj belong fox transcript factor famili regard diagnost prognost biomark therapeut target various cancer aim studi investig role foxj prostat carcinoma
D002277;D011471
T191
36,261,185
insulin resist microalbuminuria patient impair fast glucos versus hemoglobin ac defin prediabet studi investig differ among patient impair fast glucos ifg hemoglobin ac hbac defin prediabet ac pdm compar insulin resist preval microalbuminuria mau individu
D011236;D007333;D061385
T121;T047;T046
36,261,184
genom analysi carbapenemas produc escherichia coli isol analyz whole genom sequenc increas trend escherichia coli produc extend spectrum beta lactamas carbapenemas global public health concern sequenc type st high risk clone like respons global distribut e coli carri carbapenemas gene bla kpc studi carbapenemas produc e coli cpec isol recov stool patient tertiari care hospit
D004926;D001618
T007;T126;T116
36,261,183
rapid evolv fatal miliari tuberculosi covid infect infant tuberculosi tb sar cov covid two import infecti diseas caus morbid mortal worldwid activ tb infect stimul host immun respons togeth covid may lead cytokin storm immun dysregul lead multi organ failur present rare case miliari tuberculosi sar cov co infect infant month old previous healthi term boy persist cough congest becam sever ill brought emerg depart found covid posit pcr test laboratori studi show pancytopenia elev inflammatori marker abnorm coagul profil coagulopathi develop stroke sever sepsi electrolyt abnorm declin rapid within day autopsi examin show multifoc micro abscess multipl organ microscop examin show necrot foci teem mycobacteria cultur posit tuberculosi neuropatholog examin show infarct right middl posterior cerebr arteri territori patient help illumin immunolog patholog aspect two co occur infecti diseas suscept develop fatal complic sar cov infect pediatr popul
D014391;D000086382;D009169
T047;T007;T067
36,261,182
map promot breast cancer cell migrat invas regul nf b pathway investig explor molecular mechan map breast cancer cell migrat invas
D001943
T191
36,261,181
associ fibrosi index covid systemat review meta analysi prognosi valu fibrosi score fib covid controversi henc conduct systemat review meta analysi investig associ fib index covid diseas progress
D000086382;D005355
T047;T046;T067
36,261,180
preval correl vitamin level hematolog biochem paramet young adult vitamin pivot role maintain healthi bone modul multipl physiolog process vitamin defici becom global burden affect member societi studi aim investig preval correl vitamin defici hematolog biochem paramet young adult colleg student hundr fourteen student men women recruit
D014807;D014808
T121;T047;T127
36,261,179
silenc snhg suppress viabil prolifer invas gallbladd carcinoma cell via target mir p long non code rna small nuclear host gene lncrna snhg implic sever malign role interact microrna mir gallbladd cancer gbc await address
D062085;D005706;D035683
T123;T191;T114
36,261,178
valproic acid induc thrombocytopenia dysmegakaryopoiesi pediatr patient valproic acid vpa effect first line anticonvuls associ sever side effect includ bone marrow suppress subsequ cytopenia howev vpa associ myelodysplasia well describ entiti seen patient vpa treatment
D013921;D009190
T047;T046;T191
36,261,177
mesenchym stem cell deriv exosom long noncod rna malat regul prolifer apoptosi migrat trophoblast cell via target mir malat confirm play vital role progress preeclampsia pe howev one spliceosom malat role mechan malat progress pe remain elus mesenchym stem cell mscs correl angiogenesi trophoblast format could maintain success pregnanc molecular mechan still unclear aim studi investig role potenti mechan malat pe
D062085;D035683;D059630;D011225
T123;T046;T025;T114
36,261,176
linc target mir pcdk axi aggrav malign colon cancer studi summar linc manifest consider oncogen potenti divers cancer howev role colon cancer cc rare studi herein attempt disclos linc mechan action function develop cc
D062085;D035683;D003110
T123;T191;T114
36,261,175
perineur invas intraduct papillari mucin neoplasm pancrea case report unusu unreport high risk featur malign progress perineur invas frequent histolog find pancreat adenocarcinoma howev perineur invas intraduct papillari mucin neoplasm ipmn precursor lesion pancreat adenocarcinoma report far report uniqu case perineur invas ipmn year old femal underw pancreatoduodenectomi high risk featur ipmn histolog evalu show increas nerv densiti connect tissu ipmn multipl foci perineur invas ipmn addit discret mm focus invas carcinoma show perineur invas chemotherapi start patient diseas free month follow case illustr previous unreport neuroplast alter neutrotrop benign neoplast compon malign ipmn
D010190;D021441;D002288;D000230;D000077779
T191
36,261,174
breast carcinoma special histolog pattern sebac differenti high frequenc microsatellit instabl case report review literatur world health organ classif breast tumor term breast sebac carcinoma invas breast carcinoma special type ibc nst sebac pattern approxim case ibc nst sebac pattern report literatur case express mismatch repair protein tumor normal report case ibc nst sebac pattern high frequenc microsatellit instabl msi h case sporad sebac pattern ibc nst msi h unrel muir torr syndrom histopatholog characterist similar msi h associ tripl negat breast carcinoma tnbc high histolog grade without tumor infiltr lymphocyt til tumor recur month follow
D055653;D001943
T191
36,261,169
compar effect initi comput tomographi invas coronari angiographi women men stabl chest pain suspect coronari arteri diseas multicentr randomis trial assess compar effect comput tomographi invas coronari angiographi women men stabl chest pain suspect caus coronari arteri diseas
D003324;D009203;D020521
T047
36,261,162
effect financi voucher incent provid uk stop smoke servic cessat smoke pregnant women cpit iii pragmat multicentr singl blind phase randomis control trial examin effect cost effect generalis accept financi incent smoke cessat pregnanc addit various organis uk stop smoke servic
D016540;D000086382
T055;T047;T067
36,261,159
threat multidrug resistantextens drug resist gram negat respiratori infect anoth pandem antibiot resist recognis global threat human health nation healthcar agenc govern medic societi well world health organ increas resist avail antimicrobi agent concern bacteri fungal viral parasit pathogen one greatest concern continu escal antimicrobi resist among gram negat bacteria result endem presenc multidrug resist mdr extrem drug resist xdr pathogen concern heighten identif mdrxdr gram negat bacteria water food sourc colonis intestin locat hospitalis patient individu communiti agent type infect pneumonia type respiratori infect among common infect caus mdrxdr gram negat bacteria associ high rate mortal futur concern alreadi heighten due emerg resist exist antimicrobi agent develop past decad treat mdrxdr gram negat bacteria scarciti novel agent development pipelin clinic scenario increas likelihood futur pandem caus mdrxdr gram negat bacteria
D016905;D012141
T047
36,261,158
respiratori virus import lesson learn covid respiratori virus infect caus sever ill capabl induc acut respiratori failur progress rapid acut respiratori distress syndrom ard ard relat poor outcom especi individu higher risk infect elder comorbid ie obes asthma diabet mellitus chronic respiratori cardiovascular diseas despit effect antivir treatment avail sever viral lung infect scarc coronavirus diseas covid pandem demonstr also need understand role airborn transmiss respiratori virus robust evid support exist better comprehens could help implement adequ measur mitig respiratori viral infect sever viral lung infect earli diagnosi risk stratif prognosi essenti manag patient biomark provid reliabl time access inform possibl help clinician manag sever lung viral infect although respiratori virus high impact global health research need improv care prognosi sever lung viral infect review discuss epidemiolog diagnosi clinic characterist manag prognosi patient sever infect due respiratori virus
D000086382;D012128;D014780
T047;T005;T067
36,261,157
manag respiratori infect hospit lower respiratori infect includ acut bronchiti influenza communiti acquir pneumonia acut exacerb copd acut exacerb bronchiectasi major caus death worldwid often affect vulner children elder impoverish paper review clinic present diagnosi sever assess treatment adult outpati lower respiratori infect paper divid section specif lower respiratori infect also dedic section covid given import ongo pandem lower respiratori infect heterogen entiti carri differ risk advers event requir differ manag strategi instanc patient acut bronchiti rare admit hospit general requir antimicrobi approxim patient seen communiti acquir pneumonia requir admiss clinician care patient lower respiratori infect face sever challeng includ increas popul patient immunosuppress potenti need diagnost test may readili avail antibiot resist social aspect place patient higher risk manag principl patient lower respiratori infect includ knowledg local surveil data strateg use diagnost test accord surveil data judici use antimicrobi
D000086382;D012141;D017714;D001991;D011014;D000890
T121;T047;T050;T067
36,261,156
non aspergillus mould lung infect non aspergillus filament fungi caus invas mould infect increas last year due widespread use anti aspergillus prophylaxi increas complex surviv immunosuppress patient studi report invas mould infect epidemiolog mucoral frequent isol group follow either fusarium spp scedosporium spp overal incid low relat mortal exceed high patient haematolog malign haematopoiet stem cell transplant recipi compris classic group risk infect non aspergillus mould due profound immunosuppress vast use anti aspergillus prophylaxi solid organ transplant recipi also face high risk especi receiv lung transplant due direct exposur graft mould spore alter mechan immunolog elimin intens associ immunosuppress diagnos non aspergillus mould challeng due unspecif symptom radiolog find lack specif biomark low sensit cultur howev advent molecular techniqu may prove help mucormycosi fusariosi scedosporiosi hold differ regard clinic paradigmat present prefer antifung therapi surgeri might option especi mucormycosi final various promis strategi restor enhanc host immun respons current evalu
D009091
T047
36,261,141
matern hypertens disord pregnanc mortal offspr birth young adulthood nation popul base cohort studi examin associ matern hypertens disord pregnanc hdp overal caus specif mortal offspr birth young adulthood
D011225;D004461;D046110;D003920
T047;T046
36,261,130
bay novel trifluoromethyl pyrimidinedion base bcat inhibitor chemic probe branch chain amino acid transaminas bcat enzym catalyz first reaction catabol essenti branch chain amino acid branch chain keto acid form glutam known play key role differ cancer type report new structur class bcat inhibitor trifluoromethyl pyrimidinedion identifi high throughput screen campaign subsequ optim guid seri x ray crystal structur potent dual bcat inhibitor bay display high cellular activ good select along negat control bay bay donat chemic probe structur genom consortium
D000637;D000597
T123;T126;T116
36,261,128
feasibl telemedicin patient parkinson brazilian public health system telemedicin patient parkinson feasibl cost effect satisfactori howev feasibl modal care subpopul known real life scenario develop countri like brazil
D017216;D019114;D020734
T060;T058;T050;T047
36,261,127
preoper neutrophil lymphocyt ratio predict valu surviv patient brain metastasi neutrophil lymphocyt nlr monocyt lymphocyt mlr platelet lymphocyt ratio plr red blood cell distribut width rdw previous studi predictor surviv differ malign
D009504;D001932
T191;T025
36,261,126
fast ed scale prehospit triag larg vessel occlus result field acut ischem stroke ai extrem time sensit condit field triag stroke patient consid care balanc best destin time deliveri intraven andor endovascular reperfus therapi field assess stroke triag emerg destin fast ed scale shown accuraci compar nation institut health stroke scale nihss howev test field
D000083242;D004632;D020521;D002545
T061;T093;T047;T046;T058
36,261,124
chang major odor grape juic manufactur dornfeld red wine applic aroma extract dilut analysi aeda distil prepar fresh squeez juic dornfeld grape reveal z hex enal tran epoxi e dec enal highest flavor dilut fd factor contrast final dornfeld wine prepar thereof highest fd factor found phenylethyl acet phenylethan ol e damascenon howev exampl among other z hex enal longer appear import odor monitor olfactori chang occur singl process step dornfeld grape final wine select odor grape juic must young well age wine batch dornfeld grape quantit particular z hex enal hexan decreas consider mash expect concentr yeast metabolit eg odor activ alcohol ester drastic increas ferment reveal influenc barrel age odor dornfeld wine age either barriqu barrel steel tank compar
D027843;D014920;D055549
T129;T116;T109;T168;T002
36,261,114
evalu digit health capabl scale use digit health indic health servic provid must understand digit health capabl drive digit transform strateg inform manner littl known assess benchmark digit matur capabl scale across entir jurisdict public health care system across state queensland australia ambiti year digit transform strategi
D003695;D019985
T081;T058;T093
36,261,113
document burden nurs role clinician burnout syndrom purpos studi understand relationship document burden clinician burnout syndrom nurs work direct patient care offic nation coordin consid document burden high prioriti problem howev presenc document burden nurs work direct patient care well known furthermor presenc document burden link develop clinician burnout syndrom
D000077062;D002055
T048
36,261,111
enhanc lead copper remov wastewat adsorpt onto magnesium oxid homogen embed hierarch porous biochar remov non biodegrad pb cu top prioriti wastewat purif adsorpt green technolog remov herein mgo embed granular hierarch porous biochar hp mgo bc fabric pyrolysi porous mg infus chitosan bead mgo nanoparticl homogen embed throughout hierarch porous biochar matrix high densiti access manner thus provid larg number easili access adsorpt site pb cu sorption capac hp mgo bc mgg ph respect could effect remov pb cu across broad ph rang show excel adsorpt effici presenc interf cation also possess excel reusabl fix bed oper bv l bv l synthet pb cu wastewat could purifi hp mgo bc pack column respect adsorpt mechan involv miner precipit ion exchang surfac coordin
D062065;D014874
T131;T083;T069
36,261,079
effect icariin allevi schizophrenia like symptom regul mir patpbmtor signal pathway schizophrenia group sever mental disord icariin main activ compon epimedium possess therapeut effect various neurodegen diseas present studi investig whether icariin effect allevi schizophrenia like symptom explor under molecular mechan development schizophrenia rat model employ week repeat mk administr establish icariin oral administr time per day week mk administr open field test oft novel object recognit rotarod morri water maze mwm perform examin therapeut effect icariin behaviour abnorm hematoxylin eosin stain hippocampus slice mtt assay calceinpi stain sk n sh cell treat mk carri assess neuroprotect effect icariin furthermor regul icariin mir patpbmtor signal pathway examin rt pcr western blot result show icariin allevi mk induc anxieti recognit memori deficit oft respect addit weaken motor coordin caus mk restor icariin mwm test also show icariin improv mk induc impair spatial memori swim abil furthermor brain grey matter atrophi cytotox cell apoptosi caus mk elimin icariin last icariin regul express mir p atpb enhanc phosphoryl pik akt mtor conclus studi reveal icariin may therapeut effect schizophrenia like disord via regul mir patpbmtor signal suggest icariin potenti becom antipsychot drug
D035683;D012559
T123;T114;T048
36,261,068
dipol vortex sheet base model fish swim elucid hydrodynam fish swim critic identifi process under fish orient school due mathemat tractabl model base potenti flow prefer studi bidirect interact fish surround dipol base model assimil fish pair vortic particular entic yet thorough valid embark comput fluid dynam cfd campaign inform experiment data valid accuraci dipol base model locomotori pattern fish undergo carangiform swim reconstruct exist experiment data use input cfd simul fish swim channel flow demonstr dipol base model accur captur key featur fluid flow predict elong flow streamlin around fish evid cfd address issu propos altern model replac vortex pair sheet along fish length use pair vortex sheet span approxim fish bodi length separ distanc approxim bodi width model success predict fluid flow around swim fish rang background flow speed channel width propos model show improv accuraci cost mild increas comput effort therebi constitut ideal basi research fish hydrodynam
D013550;D057446
T056;T070
36,261,050
psma fdg pet predict prognost biomark patient given lu lu psma versus cabazitaxel metastat castrat resist prostat cancer therap biomark analysi randomis open label phase trial previous result therap trial show treatment lutetium lu lu psma improv frequenc prostat specif antigen psa respons rate progress free surviv compar cabazitaxel men metastat castrat resist prostat cancer studi aim analys gallium ga ga psma pet psma pet f fluoro deoxi glucos pet fdg pet imag paramet predict prognost biomark patient popul
D017430;D064129
T129;T191;T126;T116
36,261,048
lead edg vortex swift like high aspect ratio wing nonlinear swept back geometri lead edg vortex lev common flow structur form wing high angl attack year lev exploit augment lift man made slender delta wing aircraft howev recent observ suggest natur flyer high aspect ratio high ar wing common swift apus apus also generat lev glide hypothes planform shape nonlinear sweep increas toward wingtip enabl format control lev paper investig whether stationari lev form nonlinear swept back high ar wing inspir swift wing shape evalu characterist potenti aerodynam benefit particl imag velocimetri piv measur perform water flume high ar swept back wing inspir swift wing experi perform four spanwis section rang angl attack chord base reynold number stationari lev structur identifi across wingspan util proper orthogon decomposit pod method angl attack size circul stationari lev found grow toward wingtip nonlinear manner due shear layer feed spanwis transport mass vortic within lev thus confirm nonlinear high ar swept back wing generat stationari lev result suggest common swift generat stationari lev swept back wing glide slower higher rate descent lev potenti support weight
D005426;D014921
T040;T017
36,261,046
improv swim perform school fish via lead edg vortex enhanc hydrodynam school fish subject continu investig last year fish school exhibit varieti arrang sever distinct mechan propos explain hydrodynam benefit school current studi use direct numer simul show caudal fin swimmer trail anoth similar swimmer signific improv swim perform posit wake induc flow lead fish enhanc lead edg vortex lev fin trail fish improv thrust effici trail fish possibl mechan mechan under interact effect quantit analyz appli forc partit method power data driven method partit pressur forc fish mechanist distinct compon analysi reveal lev fin domin overal thrust product swimmer enhanc therefor provid effect robust mean har fish fish hydrodynam interact school addit confirm potenti energet benefit school lev enhanc mechan could exploit coordin swim bioinspir multi vehicl multi foil flap foil propuls system
D013550;D005399
T056;T013
36,261,043
role lipid cancer progress metastasi lipid essenti biolog function bodi eg provid energi storag act signal molecul structur compon membran howev excess lipid promot tumorigenesi colon metastat capac tumor cell metastas tumor cell goe differ stage requir lipid relat metabol structur adapt adapt includ alter lipid membran composit invad nich overcom cell death mechan promot lipid catabol anabol energi oxid stress protect purpos cancer cell also har lipid metabol modul activ stromal immun cell advantag resist therapi promot relaps especi worri given high fat intak western diet thus metabol intervent aim reduc lipid avail cancer cell exacerb metabol vulner provid promis therapeut opportun prevent cancer progress treat metastasi
D009369
T191
36,261,039
differenti mosquito attract human associ skin deriv carboxyl acid level peopl attract mosquito other mechanist basi phenomenon poor understood test mosquito attract human skin odor identifi peopl except attract unattract mosquito differ stabl sever year chemic analysi reveal high attract peopl produc signific carboxyl acid skin eman mutant mosquito lack chemosensori co receptor ira ira irb sever impair attract human scent retain abil differenti high weak attract peopl link elev carboxyl acid mosquito magnet human skin odor phenotyp genet mutat carboxyl acid receptor suggest compound contribut differenti mosquito attract understand human attract other provid insight skin odor import mosquito could inform develop effect repel
D000330;D007302;D000852
T131;T204
36,261,025
activ depend translat dynam alter proteom perisynapt astrocyt process within eukaryot cell translat regul independ transcript enabl nuanc local rapid respons stimuli neuron respond transcript translate synapt activ although transcript respons document astrocyt test whether astrocyt program translat respons show seizur activ rapid chang transcript astrocyt ribosom predict downstream bdnf signal acut slice quantifi extent cue neuron activ activ translat astrocyt show translat respons requir presenc neuron indic respons non cell autonom also show induct new translat extend peripheri astrocyt final synapt proteom show new translat requir chang occur perisynapt astrocyt protein composit fear condit regul translat astrocyt neuron activ suggest addit mechan astrocyt may dynam modul nervous system function
D020543;D001253
T123;T116;T025
36,261,024
loss heat shock factor initi intracellular lipid surveil actin destabil cell sens stress initi respons pathway maintain lipid protein homeostasi howev interplay adapt mechan unclear herein demonstr imbal cytosol protein homeostasi affect intracellular lipid surveil independ ancient thermo protect properti heat shock factor hsf modul lipid metabol age regul metazoan specif nuclear hormon receptor nhr reduc hsf express destabil caenorhabd elegan enter actin network subsequ disrupt rab gtpase mediat traffick cell surfac resid nutrient transport ensu malabsorpt limit lipid avail therebi activ intracellular lipid surveil respons vesicular releas nuclear transloc nhr increas nutrient absorpt restor lipid homeostasi overal cooper regul cytosol protein homeostasi lipid surveil ensur metabol health age progress actin integr endocyt recycl lipid sens
D029742
T116
36,261,023
atlas bacteri two compon system reveal function plastic signal transduct two compon system tcss consist biggest group signal transduct pathway biolog although tcss play key role sens signal sustain surviv virul genom wide regulatori variabl conserv synergist action global tcss respons extern stimulus still uncharacter integr transcriptom sequenc dataset chromatin immunoprecipit sequenc dataset model phytopathogen pseudomona syringa illustr bacteri tcss dynam govern regulatori role chang environ reveal theme conserv variabl bacteri gene regul respons chang environ develop network base pstcsome pseudomona syringa tcs regulom contain function gene king b medium minim medium condit respect identifi tcss regul type iii secret system motil exopolysaccharid product overal studi repres import sourc studi plastic tcss among tcs contain organ
D000069296;D001426
T123;T116
36,261,022
engin human cytokineantibodi fusion protein expand regulatori cell confer autoimmun diseas protect low dose human interleukin hil treatment use clinic treat autoimmun disord due cytokin preferenti expans immunosuppress regulatori cell treg howev target immun cell activ short serum half life limit clinic potenti il treatment recent work show complex compris hil anti hil antibodi f overcom limit preferenti stimul treg immun effector cell although promis therapeut translat approach complic need optim dose ratio instabl cytokineantibodi complex leverag structur insight engin singl chain hil f antibodi fusion protein term f immunocytokin ic potent select activ expand treg f ic confer protect mous model coliti checkpoint inhibitor induc diabet mellitus result provid roadmap ic design establish treg bias immunotherapi could clinic translat autoimmun diseas treatment
D007376;D001327
T129;T047;T121;T116
36,261,021
hypothalam orexin prevent non alcohol steatohepat hepatocellular carcinoma obes non alcohol steatohepat nash occasion occur obes howev factor modul natur histori fatti liver diseas remain unknown sinc hypothalam orexin regul physic activ autonom balanc prevent obes investig role nash develop male orexin defici mice fed high fat diet hfd show sever obes progress nash fibrosi liver hepat fibrosi also develop ovariectom orexin defici femal fed hfd ovariectom wild type control moreov long term hfd feed caus hepatocellular carcinoma hcc orexin defici mice intracerebroventricular inject orexin pharmacogenet activ orexin neuron acut activ hepat mtor sxbp pathway prevent endoplasm reticulum er stress nash caus factor daili supplement orexin attenu hepat er stress inflamm orexin defici mice fed hfd autonom ganglion blocker suppress orexin action result suggest hypothalam orexin essenti factor prevent nash associ hcc obes
D065626;D006528;D008113
T047;T191
36,261,020
supercoil mediat feedback rapid coupl tune transcript transcript induc wave dna supercoil alter bind affin rna polymeras reshap biochem landscap gene regul supercoil rapid diffus transcript dynam reshap regul proxim gene form complex feedback loop howev theoret framework need integr biophys regul biochem transcript regul investig role supercoil mediat feedback within multi gene system model transcript regul influenc supercoil mediat polymeras dynam allow us identifi pattern express result physic inter gene coupl find gene syntax relat order orient gene defin express profil varianc burst dynam inter gene correl two gene system furthermor supercoil enhanc weaken biochem regul result suggest supercoil coupl behavior neighbor gene provid regulatori mechan tune transcript varianc engin gene network explain behavior co local nativ circuit
D004278;D014158
T045;T114
36,261,019
dissect genet microenvironment factor gastric tumorigenesi mice gastric cancer gc one frequent lethal malign world howev understand mechan under initi progress limit generat seri primari gc model mice genom edit gastric organoid elucid genet driver sequenti transform dysplasia well differenti poor differenti gc find orthotop gc subcutan gc even genet driver display remot metastasi suggest critic role microenviron gc metastasi singl cell rna seq analys function studi show interact fibronectin stomach specif macrophag integrin gc cell promot remot metastas taken togeth studi propos strategi model gc dissect genet microenvironment factor drive full rang gastric tumorigenesi
D005353;D013274
T123;T191;T116
36,261,018
anti inflammatori transcript cascad conserv fli human innat immun ancestr process induc pro anti inflammatori state major challeng character transcript cascad modul respons inflamm sinc drosophila glial cell miss gcm transcript factor anti inflammatori role explor regul evolutionari conserv show murin gcm mgcm gene express subpopul age microglia chronic inflamm upon lysophosphatidylcholin lpc induc central nervous system cns demyelin acut inflamm moreov mgcm condit knockout mice show increas inflammatori phenotyp upon age lpc inject hgcm express activ demyelin lesion patient multipl sclerosi final drosophila gcm express induc upon age acut challeng overexpress decreas inflammatori phenotyp altogeth data indic induc gcm cascad conserv fli human repres potenti therapeut target control inflammatori respons
D029721
T123;T116
36,261,017
smc complex travers physic roadblock bigger ring size ring shape structur mainten chromosom smc complex like condensin cohesin extrud loop dna remain howev unclear extrud dna loop chromatin bound protein use vitro singl molecul visual show nucleosom rna polymeras dcas pose virtual barrier loop extrus yeast condensin find even dna bound nanoparticl larg nm much bigger smc ring size also transloc dna loop extrus condensin cohesin even occur singl chain version cohesin ring form subunit coval link open entrap dna data show smc driven loop extrus surpris littl difficulti accommod larg roadblock loop find also show extrud dna pass smc ring pseudo topolog henc point nontopolog mechan dna loop extrus
D009707;D053758
T123;T116;T073
36,261,015
target antigen determin mechan acquir resist cell base therapi despit revolut immunotherapi cancer treatment patient eventu progress due emerg resist scenario select tumor antigen decis success clinic respons cell bispecif antibodi tcbs engin molecul includ bind site cell receptor tumor antigen use gastric cea mkn cell tcbs direct cea show mechan resist tcb depend tumor antigen acquir resist model high affin cea target tcb exhibit reduct cea level due transcript silenc revers upon aza treatment contrast tcb resist model maintain level exhibit disrupt interferon gamma signal result help design combinatori strategi increas efficaci cancer immunotherapi anticip overcom resist
D018033
T129;T121;T116
36,261,014
stress induc glucocorticoid desensit adrenoreceptor gate neuroendocrin respons somat stress male mice noradrenerg affer hypothalam corticotropin releas hormon crh neuron provid major excitatori drive hypothalam pituitari adren hpa axi via adrenoreceptor activ noradrenerg affer recruit preferenti somat rather psycholog stress stimuli stress induc glucocorticoid feed back onto hypothalamus negat regul hpa axi provid critic autoregulatori constraint prevent glucocorticoid overexposur neuropatholog whether negat feedback mechan target stress modal specif hpa activ known describ desensit adrenoreceptor activ hpa axi follow acut stress male mice mediat rapid glucocorticoid regul adrenoreceptor traffick crh neuron glucocorticoid induc receptor traffick desensit hpa axi somat psycholog stressor find demonstr rapid glucocorticoid suppress adrenerg signal crh neuron specif somat stress activ reveal rapid stress modal select glucocorticoid negat feedback mechan
D010913;D007030
T022;T030
36,261,013
stem cell age framework mechan intervent stem cell play central role tissu develop homeostasi regener decad scientif research uncov process stem cell declin tissu organism age recent pioneer technolog permit dissect under mechan inform therapeut develop age age associ disord review elucid age relat featur across differ somat stem cell type specif focus epigenet chang loss protein homeostasi system influenc factor includ chronic inflamm circadian rhythm dysregul metabol disord survey organism stem cell age summar under biolog implic point potenti biomark stem cell age discuss stem cell base therapeut strategi potenti promot healthi age combat age age relat diseas
D016922;D053687
T025;T043
36,261,012
circadian lncrna adirf bind pbaf regul renal clear cell tumorigenesi identifi adirf circadian long non code rna lncrna delet adirf uo cell alter rhythmic clock control gene express extracellular matrix gene adirf interact compon pbaf pbrmbrg complex uo cell pbrm tumor suppressor mutat clear cell renal carcinoma ccrcc case evalu adirf ccrcc cell reduc adirf express ccrcc cell decreas express pbaf suppress gene express gene partial rescu pbrm loss consist adirf act part modul pbaf adirf express correl surviv human ccrcc particular pbrm wild type mutant tumor loss adirf elimin vivo tumorigenesi partial rescu concurr loss pbrm co inject matrigel suggest pbrm independ function adirf find suggest adirf function part pbaf regul specif gene bmal clock regul oncogen lncrna
D002292;D007680;D062085
T123;T191;T114
36,261,011
microrna mediat regul onset enteroblast differenti drosophila adult intestin somat adult stem cell lineag high turnov tissu tight gene regulatori control like mammalian counterpart drosophila intestin precis adjust rate stem cell divis onset differenti base physiolog demand although notch signal indispens decis regul notch activ drive differenti stem cell progeni function matur cell well understood report commit termin differenti enterocyt ec cell fate microrna control show intestin enrich microrna mir fine tune notch signal activ specif intermedi enteroblast eb progenitor cell control ec differenti identifi insensit mrna target mir regul ebec ratio repress notch activ eb summari studi highlight post transcript gene regulatori mechan control differenti adult intestin stem cell lineag
D029721;D035683
T123;T116;T114
36,261,010
molecular interactom glioblastoma perivascular nich reveal integrin bind sialoprotein mediat tumor cell migrat glioblastoma gbm character extens microvascular hyperprolifer addit suppli blood tumor gbm vessel also provid trophic support glioma cell serv conduit migrat surround brain promot recurr enrich cd express glioma vascular cell gvcs ab express glioma tumor cell gtcs primari gbm use rna sequenc creat comprehens molecular interact map secret extracellular factor elabor gvcs interact receptor membran molecul gtcs valid find util function assay includ hydrogel base migrat assay vivo mous model demonstr one identifi factor littl studi integrin bind sialoprotein ibsp enhanc tumor growth promot migrat gtcs along vasculatur perivascular nich interactom serv resourc research communiti defin potenti function gbm vasculatur
D005909;D001932;D005910
T191
36,261,009
tif inhibit lung adenocarcinoma emt metastasi interact taftbp complex molecular underpin lung adenocarcinoma luad metastasi remain poor defin use human luad cell line find transcript intermediari factor tif bind tata box bind protein tbp competit tbp associ factor taf imped taftbp mediat interleukin il transactiv tif modifi taf multi mono ubiquityl drive nuclear export taf function taf acceler epitheli mesenchym transit emt metastasi luad cell act opposit way tif low tif high taf express level shown metastat luad specimen correl poor surviv individu luad find suggest taftbp complex requir il activ induc emt invas inhibit tif studi highlight crucial interact tif taftbp complex regul emt metastasi luad
D000077192;D008175;D035381
T123;T191;T116
36,261,008
septin barrier protect mammalian host cell pseudomona aeruginosa invas septin gtpase polymer higher order structur part cytoskeleton involv interact host wide spectrum pathogen mani pathogen foster ambigu relationship septin exploit septin uptak septin also prevent intracellular replic target autophagi demonstr septin involv defens mechan pathogen pseudomona aeruginosa enter cell via lipid zipper mechan reli interact lectin leca glycosphingolipid gb host membran leca depend invagin plasma membran trigger septin recruit site bacteri attach also find septin depend reinforc cortic actin attach site atom forc microscopi reveal format septin depend rigid barrier membran prevent bacteri penetr data suggest septin barrier repres cellular defens bacteria induc membran curvatur invas
D058112;D011550
T007;T126;T116
36,261,007
genom landscap drug respons reveal mediat anthelmint resist like pathogen parasit helminth rapid evolv resist drug treatment understand genet basi anthelmint drug resist parasit nematod key track spread improv efficaci sustain parasit control use vivo genet cross drug suscept multi drug resist strain haemonchus contortus natur host parasit system simultan map resist loci three major class anthelmint approach identifi new allel resist benzimidazol levamisol implic transcript factor cki ivermectin resist gene within locus select ivermectin resist popul worldwid express analys function valid use knockdown experi support cki associ ivermectin surviv work demonstr feasibl high resolut forward genet parasit nematod identifi variant develop molecular diagnost combat drug resist field
D007559;D000871
T121;T109
36,261,006
structur basi activ antagon receptor signal mediat interleukin interleukin il uniqu assembl p ebi subunit heterodimer cytokin signal via il r gp provid structur framework receptor activ il emerg therapeut target report crystal structur mous il complex il r human il complex srf monoclon antibodi undergo clinic trial oncolog indic one face helic p subunit interact ebi opposit face nestl interdomain elbow il r juxtapos il r ebi orient il r pair signal gp use immunoglobulin domain bind il signal complex distinct mediat il il srf bind epitop il overlap il r interact site explain potent antagonist properti collect find facilit mechanist interrog engin therapeut target il
D064094
T129;T116