PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,261,573 | scrna seq generat molecular map emerg cell subtyp sciatic nerv injuri rat patient peripher nerv injuri viral infect metabol disord often suffer neuropath pain due inadequ pharmacolog option relief develop novel therapi challeng incomplet mechanist understand cellular microenviron sensori nerv trigger emerg persist pain studi report high resolut transcriptom map cellular heterogen nave injur rat sensori nerv cover individu cell annot reveal distinguish molecular featur multipl major cell type total differ subtyp nave nerv addit subtyp emerg injuri ligand receptor analysi reveal myriad potenti target pharmacolog intervent work form comprehens resourc unpreced window cellular milieu under neuropath pain demonstr nerv injuri dynam process orchestr multipl cell type endoneuri epineuri nerv compart | D059348;D020426;D009437 | T184;T047;T037 |
36,261,572 | hospit intervent volum affect outcom emerg transcathet aortic valv implant germani literatur shown invers volum outcom relationship transcathet aortic valv implant tavi howev littl known emerg admiss germani use german nation electron health record identifi isol balloon expand self expand transfemor tavi focus patient emerg admiss patient treat tavi includ emerg case emerg admiss femal mean age year logist euroscor percentag emerg case higher lower volum higher volum center p detail center perform h p length hospit stay risk adjust differ day hospit per emerg admiss day p reimburs risk adjust differ reimburs per emerg admiss p result signific acut kidney injuri p postop delirium p perman pacemak implant p conclus regard transfemor tavi percentag emerg case higher lower volum center germani howev higher volum center show signific better outcom hospit mortal complic rate well resourc util paramet | D065467;D001024 | T061;T047 |
36,261,570 | odd ratio network postop factor reveal differ year longitudin pattern satisfact women men total knee arthroplasti time accur assess factor influenc satisfact key indic success primari total knee arthroplasti tka may help improv tka outcom perform longitudin trend analysi relat satisfact postop factor posit negat influenc patient satisfact year tka real world registri cohort womenmen show similar differ women men contribut postop factor satisfact year tka assess odd ratio similar network men strongest negat factor pain complic follow mechan problem women strongest negat factor pain knee instabl follow mechan problem complic low level sport activ sex physic activ knee societi score general function influenc posit satisfact long distanc walk associ satisfact women trend analysi reveal reduct strength satisfact relat factor year check up particular women studi demonstr key check assess evolut satisfact year tka month sex | D019645;D020370 | T061;T047 |
36,261,554 | accommod unobserv control flight attitud optic flow attitud control essenti flight capabl wherea fli robot common reli acceleromet estim attitud fli insect lack unambigu sens graviti despit establish role sever sens organ attitud stabil depend fli insect intern graviti direct estim remain unclear show attitud extract optic flow combin motion model relat attitud acceler direct although condit hover attitud unobserv prove ensu control system still stabl continu move condit fli robot experi confirm accommod unobserv manner lead stabl slight oscillatori attitud control moreov experi bio inspir flap wing robot show residu high frequenc attitud oscil flap motion improv observ present approach hold promis robot acceleromet less autopilot pave road insect scale autonom fli robot final form hypothesi insect attitud estim control potenti provid insight known biolog phenomena generat new predict reduc head bodi attitud varianc higher flight speed | D001696;D057849;D012371 | T090;T040;T070;T091 |
36,261,553 | nonlinear decis make enzymat neural network artifici neural network revolution electron comput similar molecular network neuromorph architectur may enabl molecular decis make level compar gene regulatori network non enzymat network could principl support neuromorph architectur semin proof principl report howev leakag unwant releas speci well issu sensit speed prepar lack strong nonlinear respons make composit layer delic molecular classif equival multilay neural network remain elus exampl partit concentr space region linear separ introduc dna encod enzymat neuron tuneabl weight bias assembl multilay architectur classifi nonlinear separ region first leverag sharp decis margin neuron comput various major function bit compos neuron two layer network synthet parametr famili rectangular function microrna input final connect neural logic comput hybrid circuit recurs partit concentr plane accord decis tree cell size droplet comput power extrem miniatur open avenu queri manag molecular system complex content liquid biopsi dna databas | D016571;D039301 | T170;T072 |
36,261,550 | planetari region boundari agricultur nitrogen pollut excess agricultur nitrogen use caus environment problem global extent suggest safe planetari boundari exceed earlier estim planetari nitrogen boundari howev account spatial variabl ecosystem sensit nitrogen pollut agricultur nitrogen loss use spatial explicit model establish region boundari agricultur nitrogen surplus threshold eutroph terrestri aquat ecosystem nitrat groundwat estim region boundari agricultur nitrogen pollut find overus room intensif agricultur nitrogen aggreg global surplus boundari respect threshold megatonn nitrogen per year per cent lower current nitrogen surplus megatonn nitrogen per year allow nitrogen surplus increas close yield gap region environment threshold exceed lift planetari nitrogen boundari megatonn nitrogen per year feed world without trespass region planetari nitrogen boundari requir larg increas nitrogen use effici accompani mitig non agricultur nitrogen sourc sewag water ask coordin action recogn heterogen agricultur system non agricultur nitrogen loss environment vulner | D000383;D017753;D004787;D060587;D009584 | T090;T123;T070;T082;T196;T069;T081 |
36,261,549 | gut bacteria allevi smoke relat nash degrad gut nicotin tobacco smoke posit correl non alcohol fatti liver diseas nafld under mechan associ unclear report nicotin accumul intestin tobacco smoke activ intestin ampk identifi gut bacterium bacteroid xylanisolven effect nicotin degrad colon b xylanisolven reduc intestin nicotin concentr nicotin expos mice improv nicotin exacerb nafld progress mechanist ampk promot phosphoryl sphingomyelin phosphodiesteras smpd stabil latter therefor increas intestin ceramid format contribut nafld progress non alcohol steatohepat nash result establish role intestin nicotin accumul nafld progress reveal endogen bacterium human intestin abil metabol nicotin find suggest possibl rout reduc tobacco smoke exacerb nafld progress | D001419;D009538;D065626;D000073869;D007422 | T121;T007;T109;T131;T055;T023;T047 |
36,261,548 | genet insight social organ neanderth genom analys neanderth previous provid insight popul histori relationship modern human social organ neanderth communiti remain poor understood present genet data neanderth two middl palaeolith site altai mountain southern siberia chagyrskaya cave okladnikov cave make one largest genet studi neanderth popul date use hybrid captur obtain genom wide nuclear data well mitochondri chromosom sequenc chagyrskaya individu close relat includ father daughter pair pair second degre relat indic least individu live time one third individu genom long segment homozygos suggest chagyrskaya neanderth part small communiti addit chromosom divers order magnitud lower mitochondri divers pattern found best explain femal migrat communiti thus genet data present provid detail document social organ isol neanderth communiti easternmost extent known rang | D059125 | T015 |
36,261,543 | gut microbiom divers porcin periton model sepsi anim model essenti understand mechan sepsi moreov develop assess emerg therapi clinic relev porcin model howev signific variabl host respons observ among anim thus strong demand better understand potenti sourc heterogen studi compar faecal microbiom composit anim three sampl collect differ time point anim bacteriom subject rdna profil signific differ bacteri composit associ season p season batch explain total varianc bacteriom divers season term high signific high resolut level bacteri amplicon sequenc variant level phylum divers microbiom composit could signific influenc experiment model sepsi studi warrant demonstr effect gut microbiom divers host respons confirm control gut microbiom becom standard part pre clinic sepsi experi | D000069196;D018805;D010538 | T047;T007;T001;T046 |
36,261,541 | compar assess commerci avail wound gel ex vivo human skin reveal major differ immun respons modulatori effect wound heal crucial process maintain function human skin protect barrier pathogen extern stress factor hydrogel combin antimicrobi often use moist wound care wide accept standard therapi recent report immun respons modulatori effect octenidin base hydrogel howev littl known mechan action hydrogel includ antisept molecul chlorin base chlorin releas agent respect aim studi compar assess commerci avail wound gel octenilin prontosan lavanid betadona actimari microdacyn verifort tm med regard effect secret distinct cytokin il il il matrix metalloproteinas well potenti caus alter skin structur apoptosi henc tape strip human ex vivo skin biopsi treat topic wound gel cultur h enzym link immunosorb assay enzym activ assay cultur supernat reveal octenilin demonstr signific broader anti inflammatori proteas inhibitori capac wound gel haematoxylin eosin well caspas stain treat biopsi show octenilin alter skin morpholog show least interf effect human epiderm cell compar untreat control overal studi clear demonstr total differ effect sever commerci avail hydrogel wound model give also new insight tissu compat mode action | D016753;D000891 | T129;T121;T116 |
36,261,538 | one year supplement lactobacillus reuteri atcc pta counteract degrad gut microbiota older women low bone miner densiti recent studi shown probiot supplement benefici effect bone metabol random control trial rct demonstr supplement lactobacillus reuteri atcc pta reduc bone loss older women low bone miner densiti investig mechan under effect l reuteri atcc pta bone metabol women highest chang good respond lowest chang poor respond tibia total volumetr bmd one year supplement select previous rct current studi character gut microbiom composit function well serum metabolom good respond poor respond probiot treatment secondari analysi although signific differ microbi composit high taxonom level gene rich gut microbiota signific higher p wilcoxon rank sum test inflammatori state improv p wilcoxon sign rank test good respond end month daili supplement moreov detriment chang includ enrich e coli adjust p deseq biofilm format p gsa observ poor respond allevi good respond treatment result indic l reuteri atcc pta supplement potenti prevent deterior gut microbiota inflammatori status elder women low bone miner densiti might benefici effect bone metabol | D052200;D000069196;D019936;D001851 | T047;T007;T001 |
36,261,532 | hrg homologu regul haem traffick haem enrich compart haem iron contain tetrapyrrol critic varieti cellular physiolog process haem bind protein present almost cellular compart molecular mechan regul transport use haem within cell remain poor understood show haem respons gene hrg also known transport golgi organ tango evolutionarili conserv haem chaperon crucial role traffick haem haem storag synthesi site eukaryot cell loss caenorhabd elegan hrg paralogu hrg result accumul haem lysosom relat organell haem storag site worm similar delet hrg homologu tango yeast mammalian cell induc haem overload mitochondria site haem synthesi demonstr tango bind haem transfer cellular membran apo haemoprotein notabl homozyg tango zebrafish larva develop pleiotrop symptom includ encephalopathi cardiac arrhythmia myopathi die earli develop defect partial resembl symptom human tango relat metabol encephalopathi arrhythmia hereditari diseas caus mutat tango thus identif hrg intracellular haem chaperon provid biolog basi explor aetiolog treatment tango relat disord | D017173;D029742;D006418 | T123;T116;T204;T109 |
36,261,531 | measur proton electromagnet structur deviat theoret predict visibl world found proton composit build block matter stabl natur consequ understand format matter reli explain dynam properti proton bound state fundament properti proton involv respons system extern electromagnet field character electromagnet polariz describ easili charg magnet distribut insid system distort electromagnet field moreov general polariz map result deform densiti proton subject electromagnet field disclos essenti inform under system dynam provid key decod proton structur term theori strong interact bind elementari quark gluon constitu particular interest puzzl electr general polariz proton remain unresolv two decad report measur proton electromagnet general polariz low four momentum transfer squar show evid anomali behaviour proton electr general polariz contradict predict nuclear theori deriv signatur spatial distribut induc polar proton report measur suggest presenc new yet understood dynam mechan proton present notabl challeng nuclear theori | D011522;D061766 | T061;T196 |
36,261,529 | e ligas adapt cereblon target c termin cyclic imid degron ubiquitin e ligas substrat adapt cereblon crbn target thalidomid lenalidomid therapeut agent use treatment haematopoiet malign ligand target protein degrad agent propos mimic natur occur degron howev structur motif recogn thalidomid bind domain crbn remain unknown report c termin cyclic imid post translat modif aris intramolecular cyclize glutamin asparagin residu physiolog degron substrat crbn dipeptid bear c termin cyclic imid degron substitut thalidomid embed within bifunct chemic degrad addit degron c terminus protein induc crbn depend ubiquitin degrad vitro cell c termin cyclic imid form adventiti physiolog relev timescal throughout human proteom afford degron endogen recogn remov crbn discoveri c termin cyclic imid degron defin regulatori process may affect physiolog function therapeut engag crbn | D007094;D059748;D043743 | T116;T109;T040;T126;T044 |
36,261,528 | mechan intramembran chaperon multipass membran protein multipass membran protein play numer role biolog includ receptor transport ion channel enzym multipass protein co translate insert fold endoplasm reticulum well understood prevail model posit transmembran domain tmd multipass protein success pass lipid bilay front side later gate sec protein transloc channel pat complex intramembran chaperon compris asterix ccdc engag earli tmds multipass protein promot biogenesi unknown mechan biochem structur analysi intermedi multipass protein biogenesi show nascent chain engag sec occlud latch close ccdc instead asterix bind redirect substrat locat behind sec pat complex contribut multipass translocon surround semi enclos lipid fill caviti detect multipl tmds caviti emerg ribosom suggest multipass protein insert fold behind sec accord biogenesi sever multipass protein unimped inhibitor sec later gate find elucid mechan intramembran chaperon suggest new framework multipass membran protein biogenesi endoplasm reticulum | D004721;D008565;D018832 | T026;T123;T116;T192 |
36,261,526 | ion regul gill preced gas exchang origin vertebr gas exchang ion regul gill key role evolut vertebr gill hypothes first acquir import homeostat function skin stem vertebr facilit evolut larger activ mode life howev hypothesi lack function support relev taxa character function gill skin vertebr lamprey ammocoet entosphenus tridentatus cephalochord amphioxus branchiostoma florida hemichord acorn worm saccoglossus kowalevskii presum burrow filter feed trait vertebr ancestor provid function support vertebr origin gas exchang gill increas bodi size activ direct measur vivo reveal gill domin site gas exchang ammocoet increas bodi size challeng oxygen suppli demand convers gill three taxa implic ion regul ammocoet gill respons ion flux bodi size wherea molecular marker ion regul higher gill skin amphioxus acorn worm suggest ion regul gill earlier origin gas exchang unrel vertebr size activ perhap incept pharyng pore stem deuterostom | D005880;D010100;D010802;D014714;D007477 | T078;T123;T121;T010;T196;T062;T023 |
36,261,524 | fast resuppli synapt vesicl requir synaptotagmin sustain neuron activ demand rapid resuppli synapt vesicl maintain reliabl synapt transmiss vesicl replenish acceler submicromolar presynapt ca signal yet unidentifi high affin ca sensor identifi synaptotagmin syt presynapt high affin ca sensor drive vesicl replenish short term synapt plastic synaps syt knockout mice exhibit enhanc short term depress recoveri depress slower insensit presynapt residu ca sustain neuron fire syt acceler vesicl replenish increas size readili releas pool syt also mediat short term facilit condit low releas probabl promot synapt enhanc togeth anoth high affin synaptotagmin syt ref biophys model predict syt mediat replenish facilit promot transit loos dock vesicl tight dock prime state result reveal crucial role presynapt syt mainten reliabl high frequenc synapt transmiss moreov multipl form short term plastic may converg mechan revers ca depend vesicl dock | D013572;D002118 | T026;T123;T196;T121 |
36,261,523 | clathrin associ ap control termin sting signal stimul interferon gene sting function downstream cyclic gmp amp synthas dna sens direct receptor bacteri cyclic dinucleotid small molecul activ immun infect cancer immunotherapi precis regul sting essenti ensur balanc immun respons prevent detriment autoinflamm activ sting transmembran protein traffic endoplasm reticulum golgi phosphoryl protein kinas tbk enabl signal transduct mechan end sting signal golgi remain unknown show adaptor protein complex ap control termin sting depend immun activ find ap sort phosphoryl sting clathrin coat transport vesicl deliveri endolysosom system sting degrad identifi high conserv dileucin motif cytosol c termin tail ctt sting togeth tbk depend ctt phosphoryl dictat ap engag sting cryo electron microscopi structur ap complex phosphoryl sting explain enhanc recognit tbk activ sting show suppress ap exacerb sting induc immun respons result reveal structur mechan negat regul sting establish initi signal inextric associ termin enabl transient activ immun | D033961;D002966 | T123;T116 |
36,261,522 | substrat driven assembl translocon multipass membran protein membran protein synthes endoplasm reticulum er bound ribosom dock translocon heterogen ensembl transmembran factor oper nascent chain translocon coordin action factor accommod differ substrat well understood defin composit function assembl translocon special multipass membran protein biogenesi multipass translocon distinguish three compon select bind ribosom sec complex multipass protein synthesi get emc like gel protein associ translocon pat back sec bos complex analysi insert intermedi reveal featur nascent chain trigger multipass translocon assembl reconstitut studi demonstr role multipass translocon compon protein topogenesi cell lack compon show reduc multipass protein stabil result establish mechan nascent multipass protein select recruit multipass translocon facilit biogenesi broad defin er translocon dynam assembl whose subunit composit adjust co translate accommod biosynthet need divers rang substrat | D008565 | T123;T116;T192 |
36,261,521 | evolut immun gene associ black death infecti diseas among strongest select pressur drive human evolut includ singl greatest mortal event record histori first outbreak second pandem plagu common call black death caus bacterium yersinia pesti pandem devast afro eurasia kill popul identifi loci may select black death character genet variat around immun relat gene ancient dna extract stem two differ european popul black death immun loci strong enrich high differenti site relat set non immun loci suggest posit select identifi variant high differenti within london dataset four replic independ cohort denmark repres strongest candid posit select select allel one variant rs associ product full length versus truncat erap transcript variat cytokin respons pesti increas abil control intracellular pesti macrophag final show protect variant overlap allel today associ increas suscept autoimmun diseas provid empir evid role play past pandem shape present day suscept diseas | D010930;D015010 | T047;T007 |
36,261,520 | behaviour dopaminerg signatur resili chronic stress last advers consequ individu yet other resili stressor suscept resili individu exhibit differ intrins properti mesolimb dopamin da neuron stress experi howev causal link da behaviour stress individu differ resili unknown record behaviour mice simultan da neuron activ project nucleus accumben nac signal reward tail striatum ts signal threat social defeat supervis unsupervis behaviour quantif reveal stress resili suscept mice use differ behaviour strategi distinct activ pattern da termin nac ts neural resili mice greater activ near aggressor includ onset fight back convers suscept mice greater activ offset attack onset flee also perform optogenet stimul nac project da neuron open loop random time defeat time specif behaviour use real time behaviour classif open loop fight back time activ promot resili reorgan behaviour defeat toward resili associ pattern togeth data provid link da neural activ resili resili associ behaviour experi stress | D004298;D059290;D055500 | T123;T121;T025;T109;T055 |
36,261,517 | borg giant genet element potenti expand metabol capac anaerob methan oxid exert key control greenhous gas emiss yet factor modul activ microorgan perform function remain poor understood discov extraordinarili larg divers dna sequenc primarili encod hypothet protein studi groundwat sediment wetland soil methan product oxid occur four curat complet genom linear approxim mb length share genom organ includ replichor structur long invert termin repeat genom wide uniqu perfect tandem direct repeat intergen generat amino acid repeat infer high diverg archaeal extrachromosom element distinct evolutionari origin gene sequenc similar phylogeni local diverg sequenc composit indic mani gene assimil methan oxid methanopereden archaea refer element borg identifi least differ borg type coexist methanopereden spp four distinct ecosystem borg provid methan oxid methanopereden archaea access gene encod protein involv redox reaction energi conserv exampl cluster multihaem cytochrom methyl coenzym reductas data suggest borg might previous unrecogn role metabol group archaea known modul greenhous gas emiss studi need establish function relev | D019640 | T194 |
36,261,515 | brainstem network construct threat probabl predict error neuron build block face potenti threat must estim probabl respond advantag leverag experi updat futur estim threat estim propos domain forebrain behaviour elicit brainstem yet brainstem also sourc predict error learn signal acquir updat threat estim neuropixel probe allow us record singl unit activ across region brainstem axi rat receiv probabilist fear discrimin foot shock outcom backdrop diffus behaviour signal brainstem network dorsal hub signal threat probabl neuron function remap outcom period gave rise brainstem network signal predict error shock multipl timescal result reveal brainstem network construct threat probabl behaviour predict error signal neuron build block | D005239;D001933 | T023;T041 |
36,261,501 | mesenchym stem cell bioenerget apoptosi associ risk bronchopulmonari dysplasia extrem low birth weight infant oxid stress contribut signific pathogenesi bronchopulmonari dysplasia bpd extrem low birth weight elbw infant mitochondri function regul oxid stress respons well pluripot regen abil mesenchym stem cell mscs critic mediat lung develop studi conduct test whether differ endogen msc mitochondri bioenerget prolifer surviv associ bpd risk elbw infant umbil cord deriv mscs elbw infant later die develop moderatesever bpd lower oxygen consumpt aconitas activ higher extracellular acidif indic mitochondri dysfunct increas oxid stress compar mscs infant surviv nomild bpd hyperoxia expos mscs infant die develop moderatesever bpd also lower pink express higher tom express number mitochondriacel indic cell decreas mitophagi final mscs also note prolifer lower rate undergo apoptosi cell cultur compar mscs infant surviv nomild bpd result indic mitochondri bioenerget dysfunct mitophagi deficit induc oxid stress may lead deplet endogen msc pool subsequ disrupt lung develop elbw infant increas risk bpd | D001997;D059630 | T047;T025 |
36,261,500 | peripher mononuclear cell composit platelet rich fibrin canin chronic condit platelet rich fibrin prf hot research topic regen effect human howev data report applic companion anim lack studi aim supplement current avail data prf cell composit canin patient isol peripher blood mononuclear cell pbmc name cell matur b cell monocyt macrophag adapt current protocol cell flow cytometri prf analysi canin patient popul divid three subgroup anim periodont anim neoplasia periodont healthi control individu clinic paramet patient evalu wound heal qualiti includ research present studi canin prf cell composit analyz first time use cell flow cytometri protocol higher proport pbmc cell relat wound heal cd cd cd cd cd found prf control periodont neoplasia group compar respect blood sampl impli posit outcom associ clinic prf usag canin patient proport monocyt macrophag higher prf sampl compar blood healthi patient periodont affect patient howev inflammatori neoplast process affect distribut pbmc | D000073183 | T122 |
36,261,497 | experiment solubl model crizotinib anti cancer medic supercrit carbon dioxid measur satur solubl drug supercrit fluid import paramet implement supercrit technolog pharmaceut industri co sort substanc supercrit fluid sinc attract properti like easili achiev critic temperatur moder pressur cancer increas affect mankind proper dosag treat would help minim drug usag bioavail drug main influenc drug particl size appropri technolog alway use make suitabl drug particl thus supercrit fluid technolog sft consid promis techniqu product micro nanoparticl sinc particl product process sft need solubl inform appropri solubl inform necessari present work crizotinib anti cancer drug solubl supercrit carbon dioxid scco measur report first time obtain solubl temperatur k pressur mpa measur solubl rang term mole fraction k k k k cross region observ mpa expand applic solubl data import solubl model three cubic equat sate cubic eo model along kwak mansoori mix rule investig sublim salvat enthalpi crizotinib dissolut scco calcul | D002245;D053758 | T123;T197;T073 |
36,261,495 | align invari signal realiti reconstruct hyperspectr imag use deep convolut neural network architectur energi resolut hyperspectr imag techniqu alway import matter data interpret mani case spectral inform distort element instrument broad optic transfer function electron high frequenc nois past decad advanc artifici intellig method provid robust tool better studi sophist system artifact spectral data take step toward remov artifact experiment obtain data studi evalu capabl recent develop deep convolut neural network script eelspecnet restor realiti spectral data particular strength deep neural network remov multipl instrument artifact random energi jitter sourc signal convolut optic transfer function high frequenc nois use singl train data set eelspecnet perform reduc nois restor origin realiti spectra evalu near zero loss electron energi loss spectroscopi signal scan transmiss electron microscopi eelspecnet demonstr effici robust current wide use bayesian statist method even harsh condit eg high signal broaden intens high frequenc nois | D007091;D000081862 | T059;T066 |
36,261,492 | rural urban dispar birth interv among women reproduct age nigeria nigeria like develop nation still face higher rate short birth interv sbi associ consequ advers matern child health outcom studi aim determin distribut factor associ sbi rural urban nigeria data studi extract nigeria demograph health survey ndhs statist analys descript analysi binari logist model proport sbi rural urban nigeria respect women age geopolit region educ level number children ever born signific associ sbi rural urban nigeria matern wealth index antenat care visit signific rural work status signific urban nigeria control factor higher odd sbi middl class women poor women aor ci increas anc visit reduc odd sbi visit aor ci visit aor ci slight dispar preval short birth interv rural urban area wealth index anc visit signific rural nigeria public health awar campaign strengthen drive import birth space techniqu util modern contracept breastfeed geo polit region across age strata women particular resid rural area encourag advanc educ least secondari level enlighten import anc | D001721;D012424 | T098;T102;T079 |
36,261,491 | efficaci local anesthet gel infus kit pain relief minim invas colorect surgeri open label random clinic trial continu wound infus local anesthesia effect method reduc postop pain laparoscop colorect surgeri howev subcutan local anesthesia deliv continu inject inconveni patient studi compar effect postop pain relief applic local poloxam base ropivacain hydrogel gel incis site continu infus type ropivacain administr q patient undergo laparoscop colorect surgeri prospect random non inferior studi includ patient underw laparoscop colorect surgeri incis length cm patient random assign gel group poloxam base ropivacain mg q group ropivacain mghour two day postop analgesia induc patient intraven patient control analgesia iv pca outcom measur assess h surgeri includ total amount fentanyl consum via iv pca primari endpoint amount rescu analgesia pethidin postop pain intens assess use numer rate scale nrs secondari endpoint gel administ patient q use patient signific differ total usag fentanyl two group gel group mcg q group mcg p also signific differ frequenc analges rescu medic use p nrs score postop h p h p h p h p two group gel continu deliv local anesthet oper site thus consid effect devic analgesia pain relief midlin incis laparoscop colorect surgeri | D000779;D003107 | T121;T091;T109 |
36,261,490 | distribut sourc apportion risk analysi heavi metal river sediment urmia lake basin anthropogen heavi metal dissemin natur environ riverin sediment major ecolog public health concern around world studi give insight sourc apportion potenti ecolog health risk heavi metal river sediment urmia lake basin natur world heritag locat northwestern iran comprehens sediment sampl conduct seven major river feed basin summer winter sampl analyz zinc zn copper cu cadmium cd lead pb nickel ni content suit chemic physic properti subsequ pollut index pi pollut load index pli ecolog risk er hazard quotient hq hazard index hi carcinogen risk cr indic determin mean concentr heavi metal river sediment exhibit descend order ni zn pb cu cd summer winter multivari analysi suggest zn primarili initi natur process cd pb affect human activ cu along ni deriv natur anthropogen factor pi unveil sediment sampl unpollut slight pollut zn cu pb slight moder pollut cd pli er indic demonstr sediment pose non moder pollut low moder ecolog risk respect use human health risk approach found hi valu heavi metal thi less one children adult impli non carcinogen risk analyz sediment carcinogen effect cd pb river sediment via ingest inhal dermal contact almost within toler risk children adult pi pli er hq hi cr index valu sediment sampl summer higher winter attribut greater heavi metal concentr lower water flow summer result provid practic inform better manag control heavi metal pollut aquat sedimentari ecosystem | D045483;D019216 | T196;T070 |
36,261,487 | function character mousterian tool caucasus use comprehens use wear residu analysi author discuss function character mousterian tool basi use wear residu analysi five lithic tool mezmaiskaya cave saradj chuko grotto north caucasus result repres first comprehens use wear residu analysi carri mousterian stone artefact caucasus studi unequivoc confirm use bitumen haft stone tool two differ middl paleolith cultur context defin caucasus eastern micoquian zagro mousterian | D013672;D059552 | T090;T083 |
36,261,485 | determin potenti distribut oryct monocero oryct rhinocero combin machin learn high dimension multidisciplinari environment variabl african coconut beetl oryct monocero asiat rhinocero beetl rhinocero associ econom loss plantat worldwid despit amount effort put determin potenti geograph extent pest environment suitabl map yet well establish use maxent model potenti distribut pest defin global scale result show larg area globe import product palm suitabl potenti suscept pest main determin monocero distribut temperatur annual rang follow land cover precipit season major determin rhinocero temperatur annual rang follow precipit wettest month elev area curv valu true skill statist valu obtain monocero rhinocero respect global simul area rhinocero km monocero km find inform decis make develop quarantin measur two import pest palm | D001517;D028023;D019657 | T002;T204 |
36,261,484 | deciph transcript regul catabol lignin deriv aromat rhodococcus opacus pd rhodococcus opacus pd consider potenti platform valor lignin due innat biolog funnel pathway howev transcript regul aromat catabol pathway mechan control aromat catabol operon respons differ aromat mixtur still underexplor identifi studi transcript factor aromat degrad use gfp base sensor comprehens delet analys result demonstr funnel pathway phenol guaiacol hydroxybenzo vanil control transcript activ two differ branch ketoadip pathway howev control transcript repressor addit promot activ assay reveal substrat hierarchi r opacus may ascrib transcript cross regul individu aromat funnel pathway result provid clue clarifi molecul level mechan under complex regul aromat catabol facilit develop r opacus promis chassi valor lignin | D008031;D012240 | T123;T007;T109 |
36,261,482 | claudin inhibit tumor induc lymphangiogenesi via regul pik signal pathway lymphat endotheli cell claudin tight junction protein often associ progress metastasi various tumor role claudin tumor induc lymphangiogenesi investig found increas lymphangiogenesi bf tumor claudin knockout mice accompani augment melanoma cell metastasi sentinel lymph node vitro overexpress claudin lymphat endotheli cell inhibit tube format suppress cell migrat result restrict lymphangiogenesi experi show claudin inhibit lymphat endotheli cell migrat regul pik signal pathway interest express claudin lymphat endotheli cell regul vascular endotheli growth factor c often present tumor microenviron studi indic claudin play import role signal molecul lymphat endotheli cell activ associ tumor lymphangiogenesi may contribut melanoma metastasi | D062465;D042601;D008545 | T123;T023;T191;T116 |
36,261,481 | genom wide associ studi reveal distinct genet associ relat leaf hair densiti two lineag wheat wild relat aegilop tauschii wild relat modern crop repres promis sourc genet variat mine adapt climat chang aegilop tauschii sub genom progenitor bread wheat triticum aestivum constitut reservoir genet divers improv bread wheat perform environment resili leaf hairi play essenti biolog role plant defens biotic abiot stress investig natur variat leaf hair densiti lhd among ae tauschii access genom wide associ studi perform lhd dartseq deriv singl nucleotid polymorph snp marker two lineag speci taul taul respect taul three marker trait associ mtas locat chromosom wherea taul eight mtas identifi two associ local chromosom marker explain phenotyp variat r taul taul qtls identifi chromosom might novel result reveal rapid independ evolut lhd taul compar taul major lhd candid gene identifi associ biotic abiot stress respons studi highlight signific intraspecif divers ae tauschii enhanc cultiv wheat germplasm | D000078065 | T002 |
36,261,480 | investig attent scope novel indic emot state anim human contrast emot state lead broaden narrow attent scope whether also case anim yet investig confirm measur attent scope potenti novel cognit method welfar assess studi therefor aim investig test attent scope measur emot state anim induc four putat differ emot state dog n vari valenc posit negat arous high low two differ reward context food reward experi social reward experi assess dog behaviour respons test attent scope also record heart rate variabl hrv paramet addit confirmatori affect indic experi dog show narrow attent scope induct posit valenc emot state dog posit state support reduc standard deviat normal normal r r interv sdnn reduc low frequenc lf low frequenc vlf hrv experi respons social reward examin detect statist signific differ attent scope emot state dog slight narrow attent scope negat valenc emot state lf tend reduc high arous posit treatment conclus studi provid first indic emot state also alter attent scope anim result justifi investig approach use anim welfar assess although addit studi need refin predict | D004644;D001288 | T041 |
36,261,478 | retin circul timearm retina time ratio fluorescein angiographi evalu retina specif hemodynam evalu dynam circulatori flow retin choroid circulatori diseas retrospect review medic chart eye patient underw video record fluorescein angiographi fa depart ophthalmolog st luke intern hospit april septemb mean age rang year patient men mean arm retina ar time mean retin circul rc time mean rc timear time rcar ratio ar time correl age wherea rc time rc time posit correl ar time r p moreov mean rc time signific longer rcar ratio greater retin diseas group adjust age sex patient rcar ratio frequent present retin diseas rc time rcar ratio negat correl systol blood pressur retin diseas group given ar time reflect system hemodynam rc time reflect local circulatori fluenci influenc system circulatori condit moreov rcar ratio reveal circulatori chang peculiar retina may also involv retin diseas pathogenesi studi may help elucid mechan retin diseas assist diagnosi although studi requir | D012164;D015862 | T047 |
36,261,477 | machin learn approach util dna methyl accur classifi covid diseas sever sinc onset covid pandem increas case variabl outcom continu global variant despit vaccin therapi need identifi risk individu earli would benefit time medic intervent dna methyl provid opportun identifi epigenet signatur individu increas risk util machin learn identifi dna methyl signatur covid diseas data avail ncbi gene express omnibus train cohort individu covid infect non infect extern valid dataset individu covid infect non covid associ pneumonia reanalyz data process use champ beta valu logit transform jadbio automl platform leverag identifi methyl signatur associ sever covid diseas identifi random forest classif model uniqu methyl site power discern individu sever covid diseas averag area curv receiv oper characterist auc roc model averag area precis recal curv auc prc appli extern valid model produc auc roc auc prc result understand util dna methyl covid diseas patholog serv platform inform futur covid relat studi | D000086382 | T047;T067 |
36,261,475 | high resolut micro ct infarct character segment mice stroke model character brain infarct lesion rodent model stroke crucial assess stroke pathophysiolog therapi outcom recent analysi brain lesion perform use two techniqu histolog method ttc triphenyltetrazolium chlorid time consum inaccur process mri imag faster imag method come high cost last decad high resolut micro ct sampl analysi turn simpl fast cheaper solut success describ applic brain contrast agent osmium tetroxid inorgan iodin high resolut micro ct imag fine locat quantif ischem lesion edema mous preclin stroke model use intralumin transient mcao middl cerebr arteri occlus mous stroke model identifi quantifi ischem lesion edema segment core penumbra region differ time point ischemia manual automat method transient ischem attack tia mous model quantifi striatal myelin fiber degener note whole brain reconstruct allow brain atlas co registr identifi affect brain area correl function impair methodolog prove breakthrough field provid precis detail assess stroke outcom preclin anim studi | D020521;D007455 | T123;T047;T121;T196 |
36,261,474 | new date matalascaa footprint provid new evid middl pleistocen mis hominin paleoecolog southern europ hominin footprint recent discov matalascaa huelva south iberian peninsula date thank previous studi deposit asperillo cliff ka upper pleistocen make neandert like track maker paper report new optic stimul luminesc date place hominin footprint surfac rang ka mis mis transit middl pleistocen new age impli possibl track maker individu like neandert evolutionari lineag regardless taxon attribut matalascaa footprint supplement exist partial fossil record european middl pleistocen hominin notabl first palaeoanthropolog evid hominin skeleton footprint mis mis transit discov iberian peninsula moment climat evolut warm cool thus matalascaa footprint repres crucial record understand human occup europ pleistocen | D015186;D059125 | T015 |
36,261,472 | meta analysi microbiom associ network reveal pattern dysbiosi diseas microbiom human gut microbiom compos divers dynam popul microbi speci play key role modul host health physiolog individu microbi speci found associ certain diseas state increas evid suggest higher order microbi interact may equal greater contribut host fit better understand microbi communiti dynam util network studi interact meta analysi microbi associ network healthi diseas gut microbiom take advantag larg number metagenom deriv healthi individu patient various diseas togeth recent advanc network infer deal spars composit data infer microbi associ network base co occurr gut microbi speci made network public avail resourc github repositori name gutnet meta analysi infer network abl identifi network associ featur help stratifi healthi diseas state differenti various bacteri phyla enrich proteobacteria interact diseas network addit find show contribut taxa microbi associ disproportion abund rarer taxa microbi speci play integr part shape dynam microbi communiti interact network base meta analysi reveal valuabl insight microbi communiti dynam healthi diseas phenotyp anticip healthi diseas microbiom associ network infer becom import resourc human relat microbiom research | D064307;D000069196 | T001;T032;T028;T007 |
36,261,471 | ultrasonograph chang quadricep femori thick women normal pregnanc women bed rest threaten preterm labor studi aim evalu chang quadricep femori muscl thick pregnanc postpartum period elucid effect bed rest threaten preterm labor muscl thick women normal pregnanc quadricep femori thick measur week gestat day month postpartum use ultrasonographi pregnant women treat bed rest threaten prematur labor quadricep femori thick measur week gestat postpartum women normal pregnanc quadricep femori thick increas peak week gestat follow postpartum decreas women bed rest quadricep femori thick show signific chang pregnanc postpartum period muscl signific thinner week gestat women normal pregnanc conclus signific increas quadricep femori muscl thick normal pregnanc found use ultrasonographi meanwhil pregnant women bed rest treatment quadricep femori signific thinner late third trimest normal pregnant women prolong bed rest affect normal chang quadricep femori muscl thick pregnanc postpartum period | D001510;D007752 | T061;T046 |
36,261,470 | comparison two ultra widefield color fundus imag devic visual retin peripheri microvascular lesion patient earli diabet retinopathi comparison two ultra widefield uwf color fundus cf imag devic diabet patient visual retin peripheri detect earli microvascular lesion total gradabl area tga seen non mydriat cf imag two uwf imag devic opto daytona pt zeiss clarus compar differ project area measur retin peripheri outsid standard field sf divid f tempor f superotempor f inferotempor f superonas f inferonas dr stage evalu sf tga imag devic compar use cohen eye patient year analys dr stage sf n opto n clarus mild n opto n clarus moder dr n opto depict signific area f median interquartil rang vs p clarus f vs p eye dr stage higher use opto due peripher lesion seen clarus interrat reliabl dr stage devic almost perfect sf tga reliabl detect sign earli dr high devic clarus allow better visual inferonas field opto tempor field | D003930;D003920 | T047 |
36,261,467 | size atmospher particul matter determin outcom interact rainfal process environment sustain remain risk given coupl trend econom develop air pollut risk even greater water stress world given potenti suppress effect air pollut rain format sinc suppress effect remain debat test hypothesi air pollut suppress rainfal water stress south africa done fit general linear model year histor dataset rainfal air pollut found gaseous pollut pm show signific negat correl rainfal perhap due temperatur invers caus might prevent upward rise humid air convect cloud grow high enough produc rain surpris oppos pm found rather posit signific effect pm altogeth studi support hypothesi rain prevent pollut provid nuanc depend size air particl matter achiev environment sustain grow economi reli emiss purif technolog strike trade | D000397;D000393 | T131;T069;T080 |
36,261,466 | har bioengin microb versatil platform space nutrit human enterpris solar system entail long durat voyag habit creat challeng maintain healthi diet discuss consolid multipl sensori nutrit attribut microorgan develop customiz food product system minim input physic footprint wast envisag yeast collect bioengin one carbon metabol optim nutrit divers textur tast aroma color could serv flexibl food product platform beyond potenti support human space bioengin microbi base food could lead new paradigm earth food manufactur provid greater self suffici remov pressur natur ecosystem | D017753;D009752 | T033;T070;T082 |
36,261,465 | centr pressur walk unilater transfemor amput lower limb amput impos health burden ampute thus gait assess requir prophylact clinic particular individu unilater transfemor amput utfa centr pressur cop walk one use paramet evalu gait although superimpos cop trajectori reflect gait characterist individu neurolog disord quantit characterist base cop trajectori individu utfa remain unclear thus cop trajectori investig across rang walk speed studi cop trajectori record split belt forc instrument treadmil eight walk speed asymmetri variabl paramet compar base cop trajectori individu utfa abl bodi control cop trajectori individu utfa signific larger later asymmetri variabl show signific differ anterior posterior variabl compar abl bodi control individu utfa demonstr larger later asymmetri lower speed result suggest individu utfa adopt orient specif balanc control strategi gait individu utfa could also expos higher risk fall lower walk speed | D001186;D000674 | T074;T101 |
36,261,463 | classif breast cancer histolog imag use msmv pfenet deep learn use extens histopatholog imag classif peopl field still explor new neural network architectur effect effici cancer diagnosi propos multi scale multi view progress featur encod network msmv pfenet effect classif respect densiti cell nuclei select region potenti relat carcinogenesi multipl scale view progress featur encod network extract global local featur region bidirect long short term memori analyz encod vector get categori score final major vote method integr differ view classifi histopatholog imag test method breast cancer histolog dataset iciar grand challeng propos msmv pfenet achiev formula see text formula see text accuraci patch imag level respect method potenti benefit clinic cancer diagnosi | D001943 | T191 |
36,261,462 | retrospect real life studi preoper imag minim invas parathyroidectomi primari hyperparathyroid object studi retrospect evalu preoper imag modal local parathyroid adenoma view enabl minim invas parathyroidectomi particular consid contribut f fluorocholin petct patient primari hyperparathyroid underw parathyroid surgeri singl centr year period includ underw ultrasound tc pertechnetatesestamibi spect mri f fluorocholin petct base surgic find sensit specif correct lateralis orthotop locat ultrasound tc mibi spect mri f fluorocholin petct correct later adenoma signific larger found ultrasound p spect p pre oper pth level higher singl adenoma detect scintigraphi p patient could treat minim invas procedur cure parathyroidectomi obtain patient f fluorocholin petct could shown high accur modal local parathyroid adenoma preoper obviat need total explor major patient ultrasound scintigraph result discord negat | D010282;D049950;D000236 | T047;T191 |
36,261,459 | high ras relat protein rab raba express poor prognost factor pancreat adenocarcinoma pancreat adenocarcinoma paad frequent type cancer adult worldwid search better biomark one current challeng although raba associ tumour progress multipl tumour type report paad therefor paper rna sequenc data obtain tcga cancer genom atlas gtex analys raba express differenti express gene deg paad function enrich raba associ deg analys proteinprotein interact ppi network immun cell infiltr analysi gokegg analys addit kaplanmei cox regress analys use determin clinic signific raba paad high raba express associ poor prognosi paad specimen includ subgroup patient age year male sex receiv radiotherapi histori previous alcohol consumpt p cox regress analysi show elev raba independ prognost factor prognost nomogram model includ radiotherapi status presenc postop tumour residu histolog grade overal raba overexpress may serv biomark poor outcom pancreat cancer deg pathway reveal work provid tentat molecular mechan pathogenesi progress paad | D010190;D000230 | T191 |
36,261,458 | resurveygermani veget plot time seri past hundr year germani veget plot resurvey data main sourc inform terrestri biodivers chang record reach back one centuri although data sampl plot publish yet comprehens open access dataset avail analysi compil harmonis veget plot resurvey data germani cover almost year show distribut plot data space time across habitat type european natur inform system euni addit includ metadata geograph locat plot size veget structur data allow tempor biodivers chang assess communiti scale reach back past compar data yet avail also enabl track chang incid distribut individu speci across germani summari data come level detail hold promis broaden understand mechan driver behind plant divers chang last centuri | D044822;D017753 | T070;T082;T080 |
36,261,457 | extern valid studi score emerg risk predict serp interpret machin learn base triag score emerg depart emerg depart ed experienc complex demand ed triag tool score emerg risk predict serp previous develop use interpret machin learn framework achiev good perform singapor popul aim extern valid serp korean cohort ed patient compar perform korean triag acuiti scale ktas retrospect cohort studi includ adult ed patient samsung medic center outcom day hospit mortal patient ed visit use area receiv oper characterist curv auroc assess perform serp convent score includ ktas studi popul includ ed visit covid outbreak whole cohort hospit day mortal rate serp achiev auroc outperform ktas hospit day mortal respect serp superior score hospit day mortal predict extern valid cohort serp generic intuit effect triag tool stratifi general patient present emerg depart | D014218;D000086382 | T061;T047;T067 |
36,261,456 | host genet factor relat innat immun environment sens cellular function associ human skin microbiota despit increas knowledg factor shape human microbiom host genet factor modul skin microbiom interact still larg understudi contrast recent effort character host gene influenc gut microbiota investig effect genet skin microbiota across three differ skin microenviron meta analys genom wide associ studi gwas two popul base german cohort identifi genom wide signific loci harbor candid gene involv innat immun signal environment sens cell differenti prolifer fibroblast activ howev locus pass strict threshold studi wide signific p featur includ analysi mendelian random mr analysi indic influenc staphylococci eczemadermat suggest modul effect microbiota skin diseas final transcript profil keratinocyt signific chang vitro co cultur staphylococcus epidermidi chosen repres skin commens seven candid gene gwas found overlap differenti express co cultur experi warrant research skin commens host genet makeup interact | D064307;D000069196 | T001;T032;T028;T007 |
36,261,455 | develop function composit evalu spinal bulbar muscular atrophi studi aim develop function measur combin quantit motor evalu index various bodi region patient spinal bulbar muscular atrophi sbma assess subject sbma healthi control quantit muscl strength measur function scale select tongu pressur grip power peak expiratori flow pef time walk test forc vital capac fvc compon combin valu z score creat function composit sbma function composit sbmafc also calcul standard respons mean compar sensit sbmafc exist measur total genet confirm patient sbma age sex match healthi control enrol longitudin analysi standard respons mean sbmafc larger exist rate scale receiv oper characterist roc analysi demonstr sbmafc capabl distinguish subject earli stage sbma healthi control sbmafc sensit diseas progress exist function rate scale potenti outcom measur clinic trial sbma | D055534;D009134 | T047 |
36,261,454 | implic global covid vaccin europ although global left mark econom dynam caus condit among various aspect market open product network technolog inform develop migratori flow intern cooper humanitarian support etc less pleasant side omit ie emerg framework faster diffus epidemiolog diseas thus onset sar cov virus widespread circul serious challeng provis effici solut combat especi countri fragil health system poor institut qualiti lack resourc paper aim investig implic global covid vaccin popul period analysi januari januari use mont data object studi european state captur relationship global vaccin rate appli regress model includ number factor may influenc progress vaccin order test robust result two stage least squar sls regress use regress model develop underlin global impact degre vaccin global economi competit covid manag signific effect come better interconnect global market easier access medic discoveri time countri higher vaccin rate associ higher level develop base result obtain propos polici recommend increas propens vaccin ensur equiti distribut vaccin provid financi support develop countri | D000086663;D000086382 | T200;T047;T067 |
36,261,452 | multiplex quadrupl bioluminesc assay system bioluminesc bl uniqu cold bodi radiat light generat luciferin luciferas reaction common use various bioassay molecular imag howev peak emiss bl popul blue yellow region broad spectral bandwidth thus superimpos caus optic cross leakag multiplex assay studi synthes new seri coelenterazin ctz analogu name k seri select illumin marin luciferas uniqu blue shift spectral properti optic properti specif k seri ctz analogu character marin luciferas k k found specif luminesc aluc rluc seri marin luciferas respect result confirm luciferas specif color variat ctz analogu minim cross leakag bl signal enabl high throughput screen specif ligand mixtur specif color variat substrat tailor marin luciferas singl chain bioluminesc probe creat multiplex quadrupl assay system four integr singl chain bioluminesc probe probe design select luminesc specif ligand first authent specif ctz analogu second authent uniqu multiplex quadrupl bioluminesc assay system effici optic platform specif high throughput imag multipl optic marker bioassay without optic cross leakag | D008163;D057054 | T060;T059 |
36,261,451 | supramolecular photodynam agent simultan oxid nadh generat superoxid radic given type photosensit pss hypoxia toler develop general approach prepar type pss great import remain challeng report supramolecular strategi prepar type photodynam agent simultan generat strong oxid cation radic superoxid radic introduc electron acceptor exist type ii pss proof concept three electron acceptor design co assembl classic ps produc quadrupl hydrogen bond supramolecular photodynam agent photo induc electron transfer ps adjac electron acceptor occur effici lead generat strong oxid ps anion radic acceptor transfer electron oxygen form addit photodynam agent induc direct photocatalyt oxid nadh turnov frequenc high min offer oxygen independ mechan damag tumor | D013481;D010778 | T061;T121;T109 |
36,261,450 | cryoem structur explor catalyt activ enzym pyruv carboxylas pyruv carboxylas pc tetramer enzym contain two activ site per subunit catalyz two consecut reaction mobil domain attach prosthet biotin link reaction initi biotin carboxyl subsequ carboxyl transfer pyruv substrat produc oxaloacet reaction site long distanc sever co factor play alloster regul use cryoem explor structur activ pc tetram focus activ site conform space oligom result captur mobil domain activ site expos catalyt step reaction high resolut allow identif substrat product analysi catalyt activ pc tetram reveal role certain motion enzym function structur chang presenc addit cofactor expos mechan alloster regul | D011766;D001710 | T121;T116;T127;T109;T126 |
36,261,449 | associ kcnj rs methadon respons pain manag advanc cancer end life opioid therapeut agent choic manag moder sever pain patient advanc cancer howev unpredict inter individu respons opioid therapi remain challeng clinician studi kcnj gene promis target investig genet factor contribut pain analgesia respons first associ studi polymorph kcnj respons methadon pain manag advanc cancer fifti four adult patient advanc cancer recruit across two studi site prospect open label dose individualis studi signific associ previous shown rs opioid respons opioid substitut therapi heroin addict studi chronic pain mix result seen postop pain studi associ shown rs methadon dose pain score consist studi conduct patient receiv opioid pain advanc cancer mani challeng conduct studi advanc cancer signific attrit small sampl size howev hope result studi contribut evid base allow continu develop gene drug dose guidelin clinician | D059350;D009369 | T184;T047;T191 |
36,261,447 | effect standard train combin masset sensit corticomotor excit bruxer control individu proof concept studi recent propos bruxism could repres overlearn behavior due absenc corticomotor plastic follow relev tooth clench task tct studi assess modulatori effect nerv growth factor ngf inject masset muscl corticomotor excit jaw motor perform pain limit bruxer control particip follow tct particip character definit bruxer control random assign inject right masset muscl either ngf isoton salin result studi arm iscontrol n isbrux n ngfcontrol n ngfbruxer n primari outcom masset motor evok potenti mep amplitud measur baselin tct intervent signific higher lower mep amplitud corticomotor map area observ respect iscontrol ngfcontrol group p precis accuraci depend seri target forc level signific group differ p ngf induc masset muscl sensit combin train induc effect signific impact corticomotor excit masset muscl control particip indic substanti chang corticomotor excit observ bruxer preliminari find may therapeuth implic potenti detrain manag bruxism studi larger sampl size need test new concept | D008406;D002012 | T023;T048 |
36,261,446 | character metabol effect select inhibit gut microbi glucuronidas mice hydrolysi xenobiot glucuronid gut bacteri glucuronidas reactiv previous detoxifi compound result sever gut toxic host select bacteri glucuronidas inhibitor mitig toxic impact wider host metabol process studi investig inhibitor piperazin yl tetrahydro triazino thieno c isoquinolin yl morpholin unc inh administ mice select inhibit narrow rang bacteri glucuronidas gut metabolom profil intestin content biofluid sever tissu involv enterohepat circul measur compar control anim biochem perturb observ plasma liver gall bladder contrast metabolit profil urin colon content fece gut wall alter compar control chang larg restrict compound deriv gut microbi metabol work establish inhibitor target toward bacteri glucuronidas modul function intestin microbiota without advers impact host metabol system | D005966;D000069196 | T007;T116;T126;T130;T001 |
36,261,444 | flexibl pressur temperatur dual mode sensor base buckl carbon nanofib respir pattern recognit breath condit essenti physiolog indic close relat human health wearabl flexibl breath sensor respir pattern recognit attract much attent provid physiolog signal detail person medic diagnosi health monitor etc howev present smart mask base flexibl breath sensor use singl mode detect detect relat small number respir pattern especi lack abil accur distinguish mouth breath nasal one herein smart face mask incorpor dual sens mode breath sensor recogn eight human respir pattern fabric breath sensor use novel three dimension buckl carbon nanofib mat activ materi realiz function pressur temperatur sens simultan pressur model sensor show high sensit abl precis detect pressur generat respiratori airflow temperatur model realiz non contact temperatur variat caus breath benefit capac real time recognit accur distinguish mouth breath nasal breath face mask develop monitor develop mouth breath syndrom dual sens mode sensor great potenti applic health monitor | D000076251;D057139 | T073 |
36,261,443 | runx runx differenti regul articular chondrocyt surgic induc osteoarthr develop runt relat transcript factor runx famili play various role homeostasi cartilag examin role runx runx osteoarthr develop vivo vitro runx knockout mice exhibit acceler osteoarthr follow surgic induct accompani decreas express lubricin aggrecan meanwhil runx condit knockout mice show biphas phenotyp heterozyg knockout inhibit osteoarthr decreas matrix metallopeptidas mmp express homozyg knockout runx acceler osteoarthr reduc type ii collagen cola express comprehens transcript analys reveal lubricin aggrecan transcript target gene runx indic runx sustain cola express intron enhanc sox decreas intra articular administr runx adenovirus amelior develop surgic induc osteoarthr runx protect adult articular cartilag extracellular matrix protein product normal condit runx exert catabol anabol effect inflammatori condit | D045930;D002358;D010003 | T121;T039;T024;T047 |
36,261,442 | filament fungal biofilm conserv uniqu aspect extracellular matrix composit mechan drug resist regulatori network aspergillus fumigatus filament fungus aspergillus fumigatus ubiquit mold caus invas pulmonari infect immunocompromis patient within lung fumigatus form biofilm enhanc resist antifung immun defens highlight import defin mechan under biofilm develop associ emerg properti fumigatus biofilm display morpholog architectur distinct bacteri yeast biofilm moreov fumigatus biofilm display uniqu characterist composit extracellular matrix ecm regulatori network govern biofilm format review discuss current understand form function fumigatus biofilm includ uniqu compon ecm matrix potenti drug resist mechan regulatori network govern fumigatus biofilm format potenti therapeut target structur | D001232;D000935 | T121;T004;T195 |
36,261,441 | immatur olfactori sensori neuron provid behaviour relev sensori input olfactori bulb postnat neurogenesi provid opportun understand newborn neuron integr circuit restor function newborn olfactori sensori neuron osn wire high organ olfactori bulb ob circuit throughout life enabl lifelong plastic regener immatur osn form function synaps capabl evok fire ob project neuron contribut make odor process unknown show immatur osn provid odor input mous ob form monosynapt connect excitatori neuron import immatur osn respond select odor matur osn exhibit grade respons across wider rang odor concentr matur osn suggest immatur matur osn provid distinct odor input stream furthermor mice success perform odor detect discrimin task use sensori input immatur osn alon togeth find suggest immatur osn play previous unappreci role olfactori guid behavior | D018034 | T026;T025 |
36,261,439 | color name tsiman spanish bilingu indic differenti experi content domain affect lexic access standard assumpt bilingu languag process literatur eas access word languag determin speaker overal profici languag altern could profici vari across semant categori bilingu two languag investig lexic access color term tsiman spanish bilingu given color term general frequent spanish tsiman particip may better lexic access color word spanish despit overal profici tsiman twenti two tsiman spanish bilingu took part pictur name task particip label color anim particip equal fast accur name anim tsiman spanish howev particip faster accur name color spanish tsiman except three color word frequent jaib white tsincus black jain red tsiman equal fast tsiman spanish result suggest categori specif profici better predictor lexic access overal profici | D007802;D019303 | T171 |
36,261,438 | hbegf tnf induc complex outer retin patholog photoreceptor cell extrus human organoid human organoid could facilit research complex current incur neuropatholog age relat macular degener amd caus blind establish human retin organoid system reproduc sever paramet human retina includ within macula model complex combin photoreceptor glial patholog show combin applic tnf hbegf factor associ neuropatholog suffici induc photoreceptor degener glial patholog dyslamin scar format develop simultan progress one complex phenotyp histolog transcriptom live imag mechanist studi reveal previous unknown pathomechan photoreceptor neurodegener via cell extrus could relev age amd inherit diseas pharmacolog inhibitor mechanosensor piezo mapk actomyosin avert pathogenesi piezo activ induc photoreceptor extrus model offer mechanist insight hypothes neuropatholog could use develop therapi prevent vision loss regener retina patient suffer amd diseas | D008268;D009940 | T047;T024 |
36,261,437 | remodel tumour microenviron microwav ablat potenti immunotherapi axl specif car cell non small cell lung cancer complex immunosuppress tumour microenviron tme lack tumour specif target hinder applic chimer antigen receptor car cell treatment solid tumour combin local treatment car cell immunotherapi may regul tme enhanc kill potenc car cell solid tumour show axl high express non small cell lung cancer nsclc normal tissu might target car cell therapi axl car cell alon caus moder tumour regress subcutan pulmonari metastat lung cancer cell deriv xenograft model combin microwav ablat mwa axl car cell superior antitumour efficaci mwa enhanc activ infiltr persist tumour suppress properti axl car cell axl posit nsclc patient deriv xenograft tumour via tme remodel combin therapi increas mitochondri oxid metabol tumour infiltr car cell combin treatment induc signific tumour suppress without observ toxic human immunocompet mice synergist therapeut effect mwa axl car cell may valuabl nsclc treatment | D000076962;D002289;D008175 | T129;T191;T116;T192 |
36,261,436 | preval acut neurolog complic patholog neuroimag find critic ill covid patient without vv ecmo treatment acut brain injuri intracerebr hemorrhag ich ischem stroke report critic ill covid patient well patient treat veno venous vv ecmo independ covid status purpos studi compar critic ill covid patient without vv ecmo treatment regard acut neurolog symptom patholog neuroimag find pnif long term deficit singl center studi conduct critic ill covid patient februari june demograph clinic laboratori paramet extract hospit databas retrospect imag modal includ head comput tomographi ct magnet reson imag mri follow mri neurolog examin perform survivor month primari occurr patient patient receiv vv ecmo treatment sixti four patient vv ecmo develop acut neurolog symptom patholog level arousalbrain stem functionmotor respons icu stay underw neuroimag brain ct primari modal critic ill covid patient receiv vv ecmo treatment signific lower surviv hospit stay compar without p among patient treat vv ecmo show acut pnif one imag modal icu stay vs patient overal covid icu cohort furthermor show primari secondari ich sever vs overal exhibit sever ich vs overal found non hemorrhag cerebr infarct vs overal weak posit correl patient treat vv ecmo develop acut neurolog symptom howev associ vv ecmo treatment acut pnif neglig two survivor one vv ecmo treatmenton without show innumer microhemorrhag predomin involv juxtacort white matter none survivor exhibit diffus leukoencephalopathi everi seventh covid patient develop acut neurolog symptom icu stay everi twenti fifth patient pnif most ich vv ecmo found weak risk factor neurolog complic result higher imag rate pnif although logist complex repeat neuroimag thus consid critic ill covid patient sinc ich may impact treatment decis outcom | D015199;D000086382 | T061;T047;T067 |
36,261,433 | helic ultrastructur metalloproteas meprin complex small molecul inhibitor zinc depend metalloproteas meprin predomin express brush border membran proxim tubul kidney enterocyt small intestin colon normal tissu homeostasi meprin perform key role inflamm immun extracellular matrix remodel dysregul meprin associ acut kidney injuri sepsi urinari tract infect metastat colorect carcinoma inflammatori bowel diseas accord meprin target drug discoveri program contrast meprin meprin secret extracellular space whereupon oligomeris form giant assembl largest extracellular proteas identifi date mda use cryo electron microscopi determin high resolut structur zymogen matur form meprin well structur activ form complex prototyp small molecul inhibitor human fetuin b data reveal meprin form giant flexibl left hand helic assembl rough nm diamet find oligomeris improv proteolyt thermal stabil impact substrat specif enzymat activ furthermor structur comparison meprin reveal uniqu featur activ site meprin helic assembl broad | D060752;D008666 | T123;T126;T116 |
36,261,431 | spatial transcriptom profil normal human liver comprehens studi spatial cellular anatomi human liver critic address cellular origin liver diseas conduct spatial transcriptom normal human liver tissu section provid detail inform liver zonat transcript level present high qualiti spot normal liver two human donor dataset cell main hepatocyt classifi four sub group collect data provid reliabl refer studi spatial heterogen liver lobul | D020869;D008099 | T063;T023;T059 |
36,261,429 | intrins connect within affect salienc network moder adolesc suscept negat posit peer norm adolesc equal suscept peer influenc peer influenc exert posit rather negat effect use rest state function magnet reson imag current studi examin intrins function connect network associ process social cognit affect stimuli predict adolesc n age year prosoci tendenc riski behavior context posit negat peer norm test moder role four candid intrins brain network associ mental cognit control motiv relev affect salienc peer influenc suscept intrins connect within affect salienc network signific moder associ peer norm adolesc behavior beyond network adolesc high intrins connect within affect salienc network report greater prosoci tendenc context posit peer norm greater risk take behavior context negat peer norm contrast peer norm associ adolesc behavior individu low affect salienc within network intrins connect mental network cognit control network motiv relev network associ individu differ peer influenc suscept studi identifi key neural mechan under differenti suscept posit negat peer influenc earli adolesc particular emphasi role affect salienc tradit mental regulatori motiv process | D001931;D001921 | T062;T060;T023 |
36,261,428 | untangl thread cellulos mercer natur occur plant cellulos abund renew resourc consist fiber long polym chain tight pack parallel array either two crystal phase collect refer cellulos mercer process involv treatment sodium hydroxid cellulos goe convers anoth crystal form call cellulos ii within everi chain remark chang direct design neutron diffract experi deuterium label order understand chang cellulos chain direct possibl show mercer bacteri cellulos chain fold back zigzag pattern form crystallin anti parallel domain result provid molecular level understand one wide use industri process improv cellulos materi | D002482;D033363 | T123;T122;T059;T109 |
36,261,424 | model nativ seed synuclein aggreg relat cellular dysfunct dopaminerg neuron deriv new set isogen ipsc line snca multipl triplic snca gene encod protein alpha synuclein syn rare caus aggress earli onset parkinson herein generat ipsc two sibl recent describ compact snca gene triplic suffer sever motor impair psychiatr symptom cognit deterior use crisprca gene edit snca copi inactiv target indel mutat generat panel isogen ipsc decrement number none function snca gene allel differenti ipsc line midbrain dopaminerg da neuron cultur character syn aggreg nativ seed condit evalu associ cellular dysfunct util new nanobodi base biosensor combin super resolv imag abl visual measur syn aggreg earli da neuron unstimul condit calcium dysregul mitochondri alter first patholog sign detect earli differenti da neuron cultur acceler syn aggreg induc expos neuron structur well character synthet syn fibril xsnca da neuron show highest vulner associ high level oxid da amplifi taxbp gene disrupt seed da neuron develop larg syn deposit whose morpholog intern constitu resembl lewi bodi common observ parkinson diseas pd patient brain tissu find provid strong evid isogen panel ipsc snca multipl offer remark cellular platform investig mechan pd valid candid inhibitor nativ seed syn aggreg | D057026;D010300 | T047;T025 |
36,261,423 | reduc alcohol prefer intak fecal transplant patient alcohol use disord transmiss germ free mice alcohol use disord major caus morbid requir newer treatment approach previous show random clinic trial alcohol crave consumpt reduc fecal transplant determin could transmit microbi transfer germ free male cbl mice receiv stool steril supernat collect trial particip pre post fecal transplant found mice colon post fecal transplant stool supernat reduc ethanol accept intak prefer versus pre fecal transplant colon mice microbi taxa higher post fecal transplant human also associ lower murin alcohol intak prefer major differenti express gene immun respons inflamm oxid stress respons epitheli cell prolifer occur intestin rather liver prefront cortex find suggest potenti therapeut target gut microbiota microbi intestin interfac alter gut liver brain axi reduc alcohol consumpt human | D000069467;D000437 | T061;T048 |
36,261,422 | posit mood alik differenti affect amplif effect elat versus calm mental imageri young adult report hypoman like experi posit mood amplif hallmark bipolar disord spectrum bpds need better understand cognit mechan contribut elev mood generat vivid emot compel mental imageri propos act emot amplifi bpds use posit mental imageri generat paradigm manipul affect subclin bpds relev sampl report high n vs low n hypoman like experi mood disord questionnair mdq particip random elat calm mental imageri condit rate momentari affect four time across experiment session hypothes greater affect increas high vs low mdq group assign elat vs calm imageri generat condit hypothes affect increas high mdq group would particular appar type affect typic associ hypo mania ie suggest high activ level mix model time seri analysi show high mdq group affect increas steepli sustain manner time elat imageri condit shallowli calm low mdq group show amplif effect analysi affect cluster show high mdq mood amplif elat imageri condit pronounc activ affect state experiment model bpds relev mood amplif show evid posit mental imageri drive chang affect high mdq group target manner find inform cognit mechan mood amplif spotlight prevent strategi target elat imageri potenti retain calm imageri preserv adapt posit emot | D000087122;D001714 | T033;T048 |
36,261,421 | p promot tumor recurr regul radiat induc convers glioma stem cell vascular like cell glioma stem cell gsc exhibit plastic respons environment therapeut stress lead tumor recurr under mechan remain larg unknown employ singl cell whole transcriptom analys uncov radiat induc dynam shift function state glioma cell allow acquisit vascular endotheli like pericyt like cell phenotyp vascular like cell provid trophic support promot prolifer tumor cell select deplet result reduc tumor growth post treatment vivo mechanist acquisit vascular like phenotyp driven increas chromatin access hk acetyl specif vascular gene allow increas express post treatment block p histon acetyltransferas activ revers epigenet chang induc radiat inhibit adapt convers gsc vascular like cell tumor growth find highlight role p radiat induc stress respons suggest therapeut approach prevent glioma recurr | D009364;D005910 | T191 |
36,261,419 | molecular architectur glycogen commit ppptg holoenzym delic altern glycogen synthesi degrad govern interplay key regulatori enzym alter activ glycogen synthas phosphorylas among pp phosphatas promot glycogenesi inhibit glycogenolysi pp howev master regul varieti cellular process conveni direct scaffold subunit ptg protein target glycogen address pp action glycogen granul lafora diseas aggress pediatr epilepsi genet alter lead ptg accumul caus deposit insolubl polyglucosan neuron report crystallograph structur ternari complex ppptgcarbohydr refin mechan ptg mediat pp recruit glycogen identifi unusu combin recruit site ii contribut overal bind affin iii conform heterogen complex solut sax analys | D006003;D006006 | T123;T126;T116;T109 |
36,261,418 | systemat design cell membran coat improv tumor target nanoparticl cell membran cm coat technolog increas appli nanomedicin entir coat procedur includ adsorpt ruptur fusion complet understood previous show major biomimet nanoparticl nps partial coat mechan under partial coat remain unclear hinder improv coat techniqu show partial coat intermedi state due adsorpt cm fragment cm vesicl latter could eventu ruptur extern forc partial coat difficult self repair achiev full coat due limit membran fluiditi build understand detail coat process develop general approach fix partial cm coat extern phospholipid introduc helper increas cm fluiditi promot final fusion lipid patch nps coat approach high ratio full coat exhibit enhanc tumor target abil comparison nps coat tradit full coat ratio result provid mechanist basi fix partial cm coat toward enhanc tumor accumul | D053758;D009369 | T191;T073 |
36,261,416 | genom lifestag specif transcriptom plant parasit nematod host reveal suscept gene involv tran kingdom synthesi vitamin b plant parasit nematod major threat crop product agricultur system scarciti classic resist gene highlight press need find new way develop nematod resist germplasm sequenc assembl high qualiti phase genom model cyst nematod heterodera schachtii provid platform first system wide dual analysi host parasit gene express time cover major parasit stage analysi hologenom plant nematod infect site identifi metabol pathway incomplet parasit complement host use combin bioinformat genet biochem approach show high atyp complet vitamin b biosynthesi parasit anim putat enabl horizont gene transfer bacterium requir full pathogen knockout either plant encod nematod encod step pathway signific reduc parasit success experi establish refer cyst nematod understand evolut plant parasit nematod show congruent differenti express metabol pathway infect hologenom repres new way find nematod suscept gene approach identifi genom edit amen target futur develop nematod resist crop | D010271;D017187;D003560 | T190;T204 |
36,261,415 | unfold protein respons revers effect glucos lifespan chemic steril c elegan metabol diseas often share common trait includ accumul unfold protein endoplasm reticulum er upon er stress unfold protein respons upr activ limit cellular damag weaken age show caenorhabd elegan fed bacteri diet supplement high glucos day adulthood hgd extend lifespan wherea expos day hgd experi shorten longev observ metabol shift hgd glucos infertil synergist prolong lifespan hgd independ daf notabl identifi upr stress sensor atf pek contribut longev hgd worm ire ablat drastic increas hgd lifespan togeth postul hgd activ otherwis quiescent upr age worm overcom age relat stress restor er homeostasi contrast young anim subject hgd provok unresolv er stress convers lead detriment stress respons | D017173;D029742 | T116;T204 |
36,261,413 | synthesi indenoquinolinon substitut quinolin via cycloaddit reaction report metal free protocol synthesi indenoquinolinon substitut quinolin via cycloaddit reaction use readili avail aminobenzaldehyd keton start materi differ quinolin deriv select synthes chang type keton dimethyl sulfoxid dmso co oxid play import role synthesi indenoquinolinon condensationoxid strategi involv format c n c c c bond advantag high yield broad substrat rang | D011804 | T109 |
36,261,409 | sublinear scale cellular proteom ploidi ploidi chang frequent natur contribut evolut function special tumorigenesi analysi model organ differ ploidi reveal increas ploidi lead increas cell nuclear volum reduc prolifer metabol chang lower fit increas genom instabl under mechan remain poor understood investig gene express chang cellular ploidi analyz isogen seri bud yeast n n show mrna protein abund scale allometr ploidi tetraploid cell show threefold increas protein abund compar haploid ploidi depend sublinear scale occur via decreas rrna ribosom protein abund reduc translat demonstr activ tor reduc increas ploidi lead diminish rrna gene repress via tor sch tup signal pathway mtorc sk activ also reduc human tetraploid cell concomit increas tup homolog tle downregul rdna transcript result suggest mtorc schsk tuptl pathway ensur proteom remodel respons increas ploidi | D020543;D057891 | T123;T116;T049 |
36,261,408 | evalu microbi air qualiti aerosol distribut larg dental clinic evalu microbi air qualiti dental clinic procedur larg clinic set increas patient capac | D000391;D000397 | T069;T067;T080 |
36,261,407 | autofluoresc spectra imag differenti restor dental resin tooth compar autofluoresc af spectra resin product teeth determin type non invas test feasibl differenti resin product teeth resin repair | D003188;D014070 | T122;T023 |
36,261,406 | effect unfilt cigarett margin bone loss dental implant singl center year retrospect clinic studi retrospect clinic studi evalu radiograph analysi effect unfilt filter tobacco cigarett smoke margin bone loss mbl subject dental implant | D015921;D016301;D062789 | T073;T109;T131;T047;T074 |
36,261,405 | impact type bond agent adhes cad cam dentur base teeth manufactur use differ techniqu preliminari studi evalu two agent bond dentur base teeth manufactur either stereolithographi sla subtract mix techniqu | D003819;D001840 | T061;T074 |
36,261,404 | bond strength zirconia ceram appli ph cycl modeland differ repair method evalu shear bond strength yttria stabil zirconia ysz ceram base type surfac treatment repair kit age method use | D020906;D001840 | T061 |
36,261,403 | influenc brush antisept soap solut surfac biolog properti acryl dentur base resin evalu influenc brush specif antisept soap solut surfac rough hard color stabil biolog properti specif heat polymer dentur base resin | D000891;D004202 | T121;T131;T167 |
36,261,402 | efficaci two dosag dexamethason administ submucos inject postop sequela third molar surgeri retrospect studi retrospect clinic studi perform compar post oper sequela submucos administr two differ low dosag dexamethason surgic extract lower third molar | D008964;D014313 | T033;T023;T047 |
36,261,401 | effect pressur cure placement techniqu bond strength resin composit human dentin evalu compar effect pressur cure resin composit bond strength dentin use self etch bond protocol | D017220;D019279 | T122 |
36,261,400 | gingiv health effect oscil rotat electr toothbrush micro vibrat novel brush head design stain control result week random control trial evalu reduct plaqu gingiv oscil rotat r smart connect electr recharg toothbrush micro vibrat use novel brush head design stain control versus manual toothbrush | D003802;D005891;D003773 | T122;T047 |
36,261,298 | myelin oligodendrocyt glycoprotein antibodi associ diseas present intracrani hypertens case report product autoantibodi myelin oligodendrocyt glycoprotein mog caus spectrum autoimmun disord includ optic neuriti transvers myeliti brainstem enceph acut dissemin encephalomyel studi present case year old woman unusu clinic present intracrani hypertens ih bilater papilledema patient present symptom increas intracrani pressur follow relaps remit cours sever month serial csf studi show increas open pressur clinic relaps csf serum test posit mog immunoglobulin g antibodi contrast enhanc mri brain show mild mening enhanc left pariet region subtl under cortic hyperintens indic possibl fluid attenu invers recoveri variabl unilater enhanc leptomening patient respond well immunosuppress therapi use rituximab present mog antibodi associ diseas mogad ih without optic neuriti rare report present first descript relaps remit cours present time symptom rais intracrani pressur without develop typic clinic manifest mogad | D009902;D019586 | T033;T047 |
36,261,277 | effect interrupt methotrex treatment covid booster vaccin respons overview abhishek boyton rj peckham n et al effect week interrupt methotrex treatment versus continu treatment covid booster vaccin immun adult inflammatori condit vroom studi randomis open label superior trial lancet respir med | D000086382;D000086663 | T200;T047;T067 |
36,261,271 | structur function dissoci human hippocamp subfield stiff memori perform age neurodegen diseas lead declin think memori abil subfield hippocampus hcsf play import role memori format recal imag techniqu sensit under hcsf tissu microstructur reveal uniqu structur function associ vulner age diseas goal studi use magnet reson elastographi mre noninvas mr imag base techniqu quantit imag viscoelast mechan properti tissu determin associ hcsf stiff differ cognit domain across lifespan eighti eight adult particip complet studi age year malefemal aim determin hcsf region strong correl differ memori perform outcom viscoelast specif hcsf region mediat relationship age perform result reveal interfer cost verbal memori task relat memori task perform signific relat cornu ammoni ca ca stiff p p respect ca ca stiff signific mediat relationship age interfer cost perform p also signific associ delay free verbal recal perform stiff dentat gyrus cornu ammoni dg ca p subiculum sub p region exemplifi function special hcsf declar memori potenti use mre measur clinic biomark assess brain health age diseas signific statement hippocamp subfield cytoarchitectur uniqu structur involv distinct aspect memori process magnet reson elastographi techniqu noninvas imag tissu viscoelast mechan properti potenti serv sensit biomark age neurodegener relat function outcom high resolut vivo imag invigor interest determin subfield function special differenti vulner age diseas appli mre probe subfield specif cognit correl indic measur subfield stiff determin integr structur support specif domain memori perform find valid high resolut mre method support potenti use subfield stiff measur clinic biomark classifi age diseas state | D006624;D008568 | T026;T023;T041 |
36,261,270 | activ induc cortic glutamaterg neuron nascent protein neuron activ initi signal cascad culmin divers outcom includ structur function neuron plastic metabol chang studi reveal activ depend neuron cell type specif transcript chang unbias quantit analysi cell specif activ induc dynam newli synthes protein nsps synthesi vivo complic cellular heterogen relat low abund nsps within proteom brain combin target express mutant metr methionin trna synthetas genet defin cortic glutamaterg neuron tight tempor control treatment noncanon amino acid azidonorleucin biotinyl nsps within short period pharmacolog induc seizur male femal mice purifi peptid tag heavi light biotin alkyn use direct tandem mass spectrometri detect biotinyl peptid quantifi activ induc chang cortic glutamaterg neuron nsps seizur trigger signific chang nsps decreas seizur protein mediat excitatori inhibitori synapt plastic includ syngap pak geph copin collybistin dna chromatin remodel protein includ rad smarca ddb differenti synthes respons activ protein like play homeostat role respons activ regul proteastasi intracellular ion control cytoskeleton remodel protein activ induc convers seizur decreas newli synthet ncam among other suggest seizur induc degrad overal identifi quantit chang activ induc nascent proteom genet defin cortic glutamaterg neuron strategi discov downstream mediat neuron plastic generat hypothes regard function signific statement activ induc neuron synapt plastic mediat chang protein landscap includ chang activ induc newli synthes protein howev identifi neuron cell type specif nascent proteom dynam intact brain technic challeng conduct unbias proteom screen identifi signific activ induc chang newli synthes protein genet defin cortic glutamaterg neuron within h pharmacolog induc seizur bioinformat analysi dynam nascent proteom indic newli synthes protein play divers role excitatori inhibitori synapt plastic chromatin remodel homeostat mechan proteasom metabol function extend understand divers plastic mechan | D020543;D000604 | T123;T126;T116 |
36,261,269 | visual depriv select reduc thalam reticular nucleus mediat inhibit auditori thalamus adult sensori loss lead widespread cross modal plastic across brain area allow remain sens guid behavior multimod sensori interact often attribut higher order sensori area cross modal plastic observ level synapt chang even across primari sensori cortic particular vision loss lead widespread circuit adapt primari auditori cortex even adult report use mice sex cross modal plastic occur even earlier sensori process pathway level thalamus modal select manner week visual depriv reduc inhibitori synapt transmiss thalam reticular nucleus trn primari auditori thalamus mgbv without chang primari visual thalamus dlgn plastic trn inhibit mgbv observ reduct postsynapt gain short term depress observ plastic cortic feedback excitatori synapt transmiss primari visual cortex dlgn trn mgbv suggest visual depriv induc plastic occur predomin level thalam inhibit provid evid visual depriv induc chang short term depress trn inhibit mgbv involv endocannabinoid cb receptor trn inhibit consid critic sensori gate select attent multimod perform henc plastic implic sensori process result suggest select disinhibit alter short term dynam trn inhibit spare thalam nucleus support cross modal plastic adult brain signific statement lose vision trigger adapt brain enhanc process remain sens observ better auditori perform blind subject previous found depriv vision adult rodent produc widespread circuit reorgan primari auditori cortex enhanc auditori process neural level report visual depriv induc plastic adult occur much earlier auditori pathway level thalam inhibit sensori process larg gate level thalamus via strong cortic feedback inhibit mediat thalam reticular nucleus trn found trn inhibit auditori thalamus select reduc visual depriv thus play role adult cross modal plastic | D063388;D013787 | T123;T023;T109 |
36,261,268 | histori previous midlif estradiol treatment perman alter interact brain insulin like growth factor signal hippocamp estrogen synthesi enhanc cognit age rat model menopaus across speci includ human elev level brain estrogen receptor er associ enhanc cognit age even absenc circul estrogen rodent short term estrogen treatment common use menopaus transit result long term increas er level hippocampus lead enhanc memori long termin estrogen treatment howev mechan increas level brain er enhanc cognit age remain unclear demonstr age femal rat insulin like growth factor igf activ er via ligand independ mechan requir concomit synthesi brain deriv neuroestrogen phosphoryl er via mapk signal ultim result enhanc memori rat model menopaus involv long term ovarian hormon depriv hippocamp neuroestrogen activ decreas alter igf activ result impair memori howev process revers short term estradiol treatment forti day estradiol exposur follow ovariectomi result mainten neuroestrogen level persist beyond period hormon treatment allow continu interact igf neuroestrogen signal elev level hippocamp er ultim enhanc memori collect result demonstr short term estradiol use follow loss ovarian function long last effect hippocamp function memori dynam regul cellular mechan promot activ er absenc circul estrogen translat impact find suggest last cognit benefit short term estrogen use near menopaus highlight import hippocamp er independ role circul estrogen regul memori age femal signific statement declin ovarian hormon follow menopaus coincid increas risk cognit declin potenti health risk current recommend menopaus estrogen therapi limit year long term consequ brain memori short term midlif estrogen therapi unclear rodent model menopaus determin mechan short term midlif estrogen exposur enhanc hippocamp function memori cognit benefit molecular chang endur long termin estrogen exposur model indic long last benefit maintain hippocamp estrogen receptor function absenc ongo estrogen exposur suggest potenti strategi combat age relat cognit declin | D004958;D000066492 | T125;T121;T041;T109 |
36,261,267 | retrospleni hippocamp synchroni retriev old memori macaqu memori event distant past reli multipl brain region littl known under neural dynam give rise abil record neural activ hippocampus retrospleni cortex two femal rhesus macaqu visual select target year old newli acquir object scene associ wherea hippocamp activ unchang memori age retrospleni cortex respond greater magnitud alpha oscil hz greater phase lock memori guid eye movement retriev old event similar old memori enhanc observ anterior cingul cortex betagamma band hz contrast remot retriev associ decreas gamma band synchroni hippocampus neocort area increas retrospleni alpha oscil decreas hippocampocort synchroni memori age may signifi shift frank memori alloc altern chang select among distribut memori represent primat brain signific statement memori depend multipl brain region whose involv thought chang time record neuron popul activ hippocampus retrospleni cortex nonhuman primat search object embed scene memoranda either newli present year old rememb old materi drove stronger oscil retrospleni cortex led greater lock neural activ search movement rememb new materi reveal stronger oscillatori synchroni hippocampus retrospleni cortex result suggest age memori may come reli exclus neocort oscil retriev search guidanc less long rang coupl hippocampus | D006624;D011939 | T026;T023;T041 |
36,261,266 | loss activ induc mitochondri atp product under synapt defect drosophila model al mutat gene encod vesicl associ membran protein b vapb caus famili form amyotroph later sclerosi al express al relat variant vapb vapbp drosophila motor neuron result morpholog chang larval neuromuscular junction nmj character appear fewer larger presynapt bouton although diminish microtubul stabil known underli morpholog chang mechan loss presynapt microtubul lack studi fli sex demonstr suppress vapbp induc chang nmj morpholog either loss endoplasm reticulum er ca releas channel inhibit ca calmodulin cam activ kinas ii camkii data suggest decreas stabil presynapt microtubul vapbp nmjs result hyperactiv camkii elev cytosol ca attribut ca dyshomeostasi delay extrus cytosol ca suggest defect ca extrus aros insuffici respons bioenerget demand neural activ depolar induc mitochondri atp product diminish vapbp neuron find point bioenerget dysfunct potenti caus synapt defect vapbp express motor neuron signific statement whether synchroni rate atp product demand lost degener neuron remain poor understood report express gene equival amyotroph later sclerosi al caus variant vesicl associ membran protein b vapb fli neuron decoupl mitochondri atp product neuron activ consequ level atp mutant neuron unabl keep bioenerget burden neuron activ reduc rate ca extrus could result insuffici energi power ca atpas result accumul residu ca mutant neuron lead alter synapt vesicl sv releas synaps develop find suggest synapt defect model al aris loss activ induc atp product | D000690 | T047 |
36,261,265 | gap junction mutat reveal outer hair cell extracellular receptor potenti drive high frequenc cochlear amplif cochlear amplif enabl enorm dynam rang hear amplifi cochlear respons low moder level sound compress loud sound amplif attribut voltag depend electromotil mechanosensori outer hair cell ohc driven chang voltag develop across cell membran low frequenc voltag chang domin intracellular receptor potenti rps howev ohc membran electr low pass filter properti attenu high frequenc rps potenti attenu amplif high frequenc cochlear respons imped high frequenc hear made vivo intracellular extracellular electrophysiolog measur organ corti male femal mice cbaj strain excel high frequenc hear cd mous strain sensit hear khz lose high frequenc hear within week postpartum cd mous strain transfect av mutat connexin gap junction protein block action gj protein reduc input resist mutat increas ohc extracellular rp erp magnitud rescu high frequenc hear howev increas organ corti resist mutat rescu high frequenc hear preserv ohc extracellular rp erp magnitud measur voltag develop across basolater membran ohc control electromotil low high frequenc sound male femal mice cd strain express av mutat demonstr erp rps drive ohc motil cochlear amplif high frequenc high frequenc erp frequenc attenu exceed rps magnitud appropri time provid cochlear amplif signific statement cochlear amplif enabl enorm dynam rang hear attribut voltag depend electromotil mechanosensori outer hair cell ohc driven sound induc voltag chang across membran ohc intracellular receptor potenti electr low pass filter hinder high frequenc hear measur intracellular extracellular voltag control ohc electromotil vivo mous strain impair high frequenc hear gap junction mutat strain rescu high frequenc hear increas organ corti resist preserv larg ohc extracellular receptor potenti reduc ohc intracellular receptor potenti impair low frequenc hear conclud intracellular potenti drive ohc motil low frequenc extracellular receptor potenti drive ohc motil cochlear amplif high frequenc | D003051;D018072 | T023;T025 |
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