PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,258,044 | sex differ activ extra hypothalam forebrain area hedon eat palat food stimul appetit without hunger unconstrain over under obes bing eat disord women prone obes bing eat men neural caus individu differ unknown anim model hedon eat prior studi found femal suscept male eat palat food sate neuropeptid orexinhypocretin orx crucial sex current studi examin potenti extra hypothalam forebrain target orx signal hedon eat measur fos induct cortic thalam striatal amygdalar area receiv substanti orx input contain receptor hungri sate male femal rat palat high sucros food consumpt test hungri rat sex ate substanti amount sate male ate much less hungri rat sate femal ate much hungri rat fos induct analysi identifi sex differ recruit specif area medial prefront cortex paraventricular nucleus thalamus pvt nucleus accumben acb central nucleus amygdala cea similar pattern across sex insular cortex strike activ infralimb cortex sate male consum least amount food uniqu correl insular cortex pvt cea well prelimb cortex acb cea sate femal sate male studi identifi key function circuit may drive hedon eat sex specif manner | D012727;D007031 | T023;T032 |
36,258,031 | network biolog analysi ph rhodopsin interactom identifi protein mrna qualiti control mechan rhodopsin essenti phototransduct mani rhodopsin mutat caus herit retin degener ph rhodopsin variant generat misfold rhodopsin protein photoreceptor quick target degrad mechan incomplet understood gain insight ph rhodopsin remov rod use mass spectrometri identifi protein interact partner ph rhodopsin immunopurifi rho phph mice compar protein interact partner wild type rhodopsin rho mice identifi protein associ ph rhodopsin protein associ wild type rhodopsin protein share wild type mutant rhodopsin protein interactom ph rhodopsin protein interactom saw loss phototransduct retin cycl rhodopsin protein traffick protein gain ubiquitin relat protein compar wild type rhodopsin protein interactom ph rhodopsin protein interactom saw enrich gene ontolog term relat er associ protein degrad er stress translat protein protein interact network analysi reveal translat ribosom qualiti control protein signific regul ph rhodopsin protein interactom protein partner identifi studi may provid new insight photoreceptor recogn clear mutant rhodopsin offer possibl novel target involv retin degener pathogenesi | D012243;D012162 | T123;T046;T116 |
36,258,030 | interpregn interv matern neonat morbid nationwid cohort studi studi aim assess associ interpregn interv ipi time childbirth concept next pregnanc matern neonat morbid world health organ current recommend ipi least month live birth reduc advers birth outcom howev assess relationship ipi perinat outcom complic confound factor conduct nationwid popul base cohort studi use swedish registri data allow adjust matern characterist health first birth studi popul consist women singleton live vagin first birth second singleton birth within five year cover women neonat ipi group six month interv month refer associ ipi morbid examin use multivari logist regress women vagin deliveri first birth interv month associ increas matern neonat morbid find question relev recommend ipi least month high incom countri | D001721;D011248 | T046;T079 |
36,258,028 | generat bovin cell line gene engin use hiv base lentivir vector human immunodefici virus type hiv base lentivir vector indispens tool gene engin mammalian cell convers lentivir vector transduct sever inhibit bovin cell previous studi demonstr inhibit caus anti lentivir host factor tripartit motif contain trim target incom hiv virion interact viral capsid studi investig sever method overcom limit applic lentivir vector bovin cell first demonstr spri domain bovin trim major determin anti viral activ second found mutat allow capsid evad rhesus macaqu trim minim rescu hiv infect bovin deriv mdbk cell third found cyclosporin reliev inhibit hiv infect monkey cell signific rescu impair hiv infect mdbk cell last success generat bovin cell line lack intact trim use crisprca techniqu trim knockout cell line display signific higher suscept hiv base lentivir vector conclus find provid promis gene engin strategi bovin cell therebi contribut innov agricultur improv anim health | D015497;D015658 | T005;T047 |
36,258,027 | matern supplement casein hydrolys yeast beta glucan late gestat lactat improv gastrointestin health piglet wean improv matern nutrit pregnancylact promis strategi maximis intestin health piglet undergo abrupt wean commerci product condit experi investig effect matern supplement casein hydrolys yeast glucan ch ybg day gestat wean day sow faecal microbi popul measur piglet gastrointestin health paramet wean sow n sowsgroup assign control diet control diet ch ybg matern supplement increas abund phylum firmicut includ member lactobacillus sow faec concomit increas caecal abund lactobacillus wean piglet compar control piglet wean supplement sow increas villus height duodenum p increas villus height crypt depth ratio jejunum well decreas express proinflammatori cytokin gene iltnftgfb tight junction gene cldn mucin gene muc duodenumjejunum compar control p conclus matern ch ybg supplement pregnancylact improv microbi structur inflammatori measur gastrointestin health piglet wean promis strategi allevi challeng occur earli abrupt wean commerci pig product | D012441;D047071 | T121;T004;T109 |
36,258,025 | evalu choroid thick oct covid patient high dimer level evalu retin choroid thick optic coher tomographi oct detect retin choroid patholog coronavirus diseas covid patient high dimer level thirti patient hospit intens care unit due sever acut respiratori syndrom coronavirus whose dimer level high period appli intern medicin outpati clinic day discharg healthi volunt similar age gender control group includ studi full ophthalmolog examin central foveal choroid thick evalu use optic coher tomographi statist analysi studi data demonstr signific differ group term age gender p also statist signific differ group term central foveal thick central choroid thick nasal nasal tempor tempor micron distanc p paramet choroid retin vascular thick affect short term covid patient hospit intens care unit | D041623;D000086382 | T060;T047;T067 |
36,258,024 | effect autochthon strain mixtur gut microbiota metabol profil cobia rachycentron canadum fish immun system topic subject offer uniqu understand defens system evolut vertebr hered gut microbiota play sever role fish well promot health growth resist bacteri invas regul energi absorpt lipid metabol howev studi fish gut microbiota face practic challeng due larg number fish varieti fluctuat environment condit differ feed habit studi carri evalu impact supplement three autochthon strain bacillus sp rcs pantoea agglomeran rcs bacillus cereus rcs mixtur diet cobia fish rachycentron canadum also chromatographi mass spectrometri high throughput sequenc combin explor composit metabolit profil gut microbiota juvenil cobia fed supplement diet trial group juvenil cobia receiv diet supplement cfu ml autochthon strain ten week control diet without supplement juvenil cobia receiv diet supplement exhibit signific improv growth without addit control haematolog indic red blood cell white blood cell corpuscular haemoglobin concentr mean corpuscular volum haemoglobin mean corpuscular haemoglobin higher supplement group similar digest enzym trypsin lipas amylas pepsin cellulos activ activ higher supplement diet indigen isol mixtur serum biochem paramet albumin globulin total protein signific higher triglycerid alanin aminotransferas aspart aminotransferas alkalin phosphatas cholesterol show signific differ hand glucos signific p higher group without supplement gene express midgut immunoglobulin coloni stimul factor receptor major histocompat complex regul nativ isol cell receptor beta major histocompat complex show signific differ gut bacteri composit alter fish receiv supplement diet autochthon strain metabolom also reveal metabol pathway consider enrich fish fed supplement diet pathway analysi base kyoto encyclopedia gene genom kegg enrich reveal differenti express metabolit involv galactos metabol tryptophan metabol carbohydr digest absorpt purin metabol abc transport function analysi bacteri communiti show differ enrich metabol pathway general compris carbohydr metabolit nucleotid metabolit amino acid metabolit heterocycl compound tryptamin cholin pigment current investig result show autochthon strain mixtur signific enhanc growth surviv innat adapt immun juvenil cobia | D000069196;D010473 | T007;T001;T013 |
36,258,023 | develop tlr agonist adjuv formul overcom earli life hyporespons dtap vaccin infect common caus mortal earli life yet broad potenti immun fulli realiz vulner popul vaccin administ infanc childhood case full benefit vaccin realiz part new adjuv cardin optim current immun approach earli life howev class adjuv present incorpor vaccin approv human use recent advanc discoveri deliveri toll like receptor tlr agonist adjuv provid new toolbox vaccinologist promin among candid adjuv synthet small molecul tlr agonist develop effect infant bordetella pertussi vaccin urgent requir resurg pertussi mani countri contemporan switch whole cell acellular vaccin context tlr adjuv base vaccin formul strategi may promis tool enhanc acceler earli life immun acellular b pertussi vaccin present studi optim formul deliveri system b structur c immunolog activ novel small molecul imidazoquinolin tlr adjuv toward human infant leukocyt includ dendrit cell upon immun neonat mice tlr adjuv overcam neonat hyporespons acellular pertussi vaccin drive helper th th bias cell iggc skew humor respons licens acellular vaccin dtap potent immun strategi may repres new paradigm effect immun pertussi pathogen earli life | D014917 | T047 |
36,258,020 | systemat review intervent recognis refer diagnos patient lung cancer symptom patient lung cancer lc often experi delay symptom onset treatment primari healthcar profession hcps help facilit earli diagnosi lc recognis earli sign symptom make appropri referr systemat review describ effect intervent aim help hcps recognis refer individu symptom suggest lc seven studi synthesis narrat outcom categoris diagnost interv referr diagnosi pattern stage distribut diagnosi time interv diagnosi treatment rapid access pathway continu medic educ general practition help reduc lc diagnost treatment delay awar campaign hcp educ help inform primari hcps referr pathway howev campaign signific impact lc referr rate reduc diagnost interv diseas outcom lc stage diagnosi recurr surviv seldom measur review find highlight need longitudin power control studi | D058005;D008175 | T191;T097 |
36,258,015 | contrafreeload kea nestor notabili comparison grey parrot psittacus erithacus contrafreeload work access food could freeli obtain rare exhibit poor understood base data grey parrot psittacus erithacus research propos correl contrafreeload play contrafreeload like subject view task play test hypothesi subject relat play parrot speci kea nestor notabili experiment task experi present eight kea contain pair hold less prefer free enclos food item examin three type contrafreeload calcul work access prefer food less prefer freeli avail food classic work access food ident freeli avail food super work access less prefer food prefer freeli avail food group level kea behav similar grey signific prefer calcul contrafreeload perform classic contrafreeload chanc signific fail super contrafreeload howev overal kea engag contrafreeload grey experi examin potenti ecolog relev task choic shell unshel walnut kea contrafreeload nut wherea two five grey signific prefer nut contrafreeload one chose chanc examin proxim adapt explan perform differenti play parrot speci elucid role play contrafreeload | D010311 | T012 |
36,258,013 | suppress heterotop ossif fibrodysplasia ossifican progressiva use aav gene deliveri heterotop ossif disabl featur fibrodysplasia ossifican progressiva ultra rare genet disord current prevent treatment patient diseas harbor heterozyg activ mutat c g prh acvr identifi recombin aav effect serotyp transduct major cell origin heterotop ossif use aav deliveri gene replac express codon optim human acvr acvrrh allel specif silenc aav compat artifici mirna combin gene replac silenc mous skelet cell harbor condit knock allel human mutant acvr patient deriv induc pluripot stem cell aav gene therapi ablat aberr activin signal chondrogen osteogen differenti acvr rh knock mice treat local earli adulthood system birth trauma induc endochondr bone format mark reduc inflamm fibroprolif respons remain larg intact injur muscl remark spontan heterotop ossif also substanti decreas acvr rh knock mice treat system birth earli adulthood collect develop promis gene therapeut prevent disabl heterotop ossif mice support clinic translat patient fibrodysplasia ossifican progressiva | D035683;D009221;D009999 | T123;T047;T046;T114 |
36,258,012 | use gd dope carbon gdf nanoparticl proton target therapi effect enhanc thermal neutron reduct simul studi two major problem proton therapi comparison gamma ray therapi proton therapi greater biolog effect risk secondari neutron proton therapi anoth unsolv problem report increas biolog effect proton therapi evalu better perform b presenc two propos nanomateri gdf gd dope carbon thermal neutron reduct due presenc gd isotop present studi base microanalysi calcul use geant mont carlo tool geant dna packag strand break measur found propos method increas effect correspond alpha particl also potenti decreas thermal neutron fluenc signific also work discuss present signific contribut secondari alpha particl total effect proton therapi | D061766;D053758 | T061;T073 |
36,258,008 | invers design anisotrop spinodoid materi prescrib diffus three dimension microstructur function materi determin effect properti like mass transport properti porous materi henc desir abl tune properti tune microstructur accord work studi class spinodoid ie spinod decomposit like structur tunabl anisotropi base gaussian random field realist yet comput effici model bicontinu porous materi use convolut neural network predict effect diffus three direct demonstr incorpor predict neural network approxim bayesian comput framework invers problem comput effici manner design microstructur prescrib diffus three direct | D038524 | T060 |
36,258,007 | failur drug repurpos covid effect excess hypothesi test weak mechanist evid current strategi search effect treatment covid reli main repurpos exist therapi develop target diseas conflict result emerg regard efficaci sever test compound later result negat number conduct ongo trial urgent need treatment pose risk fals posit result incorrect interpret evid treatment efficaci ground drug approv purpos twofold first show number drug repurpos trial explain fals posit result second assess evid treatment efficaci perspect evidenti plural argu consid mechanist evid particular need case evid clinic trial conflict low qualiti analysi applic program evid base medicin plus ebm drug repurpos trial covid studi show decis maker appli ebm author use ineffect treatment would less like analyz exampl trial assess efficaci hydroxychloroquin treatment covid mechanist evid favor therapeut power draw lesson decis maker drug agenc excess hypothesi test lead spurious find studi negat mechanist evid help discrimin genuin spurious result | D000086382 | T047;T067 |
36,258,006 | hindlimb unload induc time depend disrupt testicular histolog mice mechan unload bodi hindlimb unload hu mice induc patholog multipl organ effect test poor character investig histolog raman spectroscopi mous test follow hu condit divid male cblj mice ground base control experiment group two four week hu test tissu dissect euthanasia investig histolog raman spectroscop analysi found hu induc atrophi test irrespect time durat p histolog analysi reveal hu induc epitheli thin lumin widen spermatozoa declin seminifer tubul mous test addit found thicken epididym epithelia tunica albuginea chang accompani general depress raman spectra indic alter concentr andor orient sever molecul also report reduc signal intens hydroxyprolin tryptophan potenti contribut testicular patholog hu taken togeth find indic two four week hu induc disrupt testicular architectur molecular phenotyp result may implic understand andor treat male infertil associ prolong bed rest spaceflight | D019417;D013737 | T062;T023 |
36,258,003 | prophylact antibiot postcataract surgeri endophthalm systemat review network meta analysi million eye reveal optim antibiot prophylact regimen postop endophthalm poe conduct systemat review network meta analysi total elig origin articl includ two random control trial identifi total poe case occur eye intracamer inject vancomycin best prevent effect odd ratio confid interv ci correct p valu p score follow intracamer inject cefazolin ci correct p valu p score cefuroxim ci correct p valu p score moxifloxacin ci correct p valu p score one random control trial support intracamer cefuroxim moxifloxacin random control trial evalu vancomycin cefazolin sensit analysi focus administr rout reveal intracamer inject ci correct p valu p score signific decreas risk postop endophthalm conclus intracamer inject either vancomycin cefazolin cefuroxim moxifloxacin prevent poe | D002387;D009877 | T061;T047 |
36,257,999 | antifung activ genom character biocontrol agent bacillus velezensi cmrp develop bio base product increas recent year speci bacillus genus wide use product develop due elev product antimicrobi molecul resist extrem environment condit endospor format context antifung potenti bacillus velezensi cmrp investig use silico predict secondari metabolit genom vitro test follow phytopathogen fungi sclerotinia sclerotiorum macrophomina phaseolina botryti cinerea silico predict indic cmrp possess sever biosynthet gene cluster bgcs capabl produc molecul antifung properti non identifi bgcs vitro assay result evidenc strong antifung activ inhibit test fungi isol molecul stabl divers physicochem condit vitro assay evidenc signific antifung activ deform hyphal structur ss biofilm format capac swarm motil colon assay observ attach colon net shape biofilm format strain transit seed nearbi structur therefor cmrp show potenti biocontrol agent various diseas agronom import use advers environment condit | D001407;D000890 | T121;T007 |
36,257,998 | phenotyp first hypothes spandrel earli metazoan evolut neo darwinian assumpt genet factor princip sourc variat upon natur select oper phenotyp first hypothesi strike us revolutionari develop would seem constitut independ sourc variabl richard watson co author argu development memori constitut one varieti phenotyp variabl version phenotyp first hypothesi especi well suit late metazoan context anim suffici histori select draw appeal development memori seem less plausibl evolutionari context earli metazoan provid interpret stuart newman account deep metazoan phylogenesi suggest spandrel addit development memori import reservoir phenotyp variabl conclud argu gerd mller side effect hypothesi illumin general propos non watsonian version phenotyp first hypothesi | D005075;D012641 | T045;T070 |
36,257,997 | intercomparison region loss estim global synthet tropic cyclon model tropic cyclon tcs caus devast damag life properti histor tc data scarc complic adequ tc risk assess synthet tc model specif design overcom scarciti model evalu abil simul tc activ studi date focus model perform applic tc risk assess studi perform intercomparison four differ global scale synthet tc dataset impact space compar impact return period curv probabl rare event hazard intens distribut land find model choic influenc costliest event particular basin limit tc activ model direct econom damag north indian ocean instanc rang billion usd yr event four hazard set furthermor provid guidelin suitabl differ synthet model various research purpos | D055867 | T070 |
36,257,996 | decis support system sustain groundwat manag crystallin hard rock implic sugarcan agricultur southern india india second largest sugarcan produc nation water footprint bcmyear met groundwat deep well larg scale groundwat manag practic found most unten affect sugarcan agrarian associ sector develop cell level km km decis support system employ integr hydro geophys investig sugarcan agro watersh km beset granit aquif system tattihalla river watersh southern india refin hydrogeolog conceptu model deriv electr resist tomographi groundwat level head account numer model model run transient mode four stress period valid calcul observ head normal rms error valid model convey robust estim groundwat budget demarc cell theoret scenario water level project increas groundwat pump rate generat show declin trend water level project year period vari magnitud vulner drought condit differ time period water level touch basement ie dri borewel infer distinct hydrogeolog properti individu cell advoc adapt cell level manag plan articl explain two cell nos detail show vari characterist aquif differ pump rate | D031786;D060587 | T081;T082;T070;T002 |
36,257,995 | evalu remov effici rural wwtp metal anion lufkin east texa usa present studi quantifi element concentr evalu remov effici lufkin wastewat treatment plant lwwtp public municip wastewat treatment plant east texa macroel na k mg ca al fe se zn p microel ni pb mn cr mo cu co v b ba detect use icp oe icp ms addit anion concentr br po f cl percent remov lwwtp assess use ion chromatographi wherea macroel influent maximum ceil limit total metal concentr effluent found usepa gl guidelin general remov effici metal lwwtp remov effici anion br cl f po addit pierson correl coeffici anion cation implic usag suggest improv treatment plant propos | D007854;D019216 | T131;T196 |
36,257,994 | distribut soil macrofauna across differ habitat eastern european alp macro invertebr import compon soil ecosystem provid wide rang crucial function ecosystem servic knowledg distribut mountain soil scarc despit import soil peopl live mountain region well downstream present dataset contain record soil macro invertebr belong nineteen taxa list class order level earthworm list speci level differ habitat type characterist eastern european alp data collect period year follow standard protocol compil singl record uniqu sampl site provid default site paramet gps coordin habitat type type manag elev exposit inclin bedrock soil type follow wrb classif data import analys global trend macroecolog pattern set basi track long term chang macrofauna composit addit dataset add still spars knowledg occurr abund alpin soil fauna taxa | D017753;D009835 | T070;T204;T082 |
36,257,993 | gene therapi primari mitochondri diseas experiment advanc clinic challeng variabl clinic biochem manifest primari mitochondri diseas pmds complex mitochondri genet proven substanti barrier develop effect diseas modifi therapi encourag data gene therapi trial patient leber hereditari optic neuropathi advanc dna edit techniqu rais expect success clinic transit genet therapi pmds feasibl howev obstacl clinic applic genet therapi pmds remain develop innov safe effect genom edit technolog vector crucial futur success clinic approv perspect review progress toward genet treatment nuclear mitochondri dna relat pmds discuss advanc mitochondri dna edit technolog alongsid uniqu challeng target mitochondri genom last consid ongo trial regulatori requir | D029242;D028361 | T047 |
36,257,991 | comparison method examin time readmiss first year life readmiss analys typic calcul time readmiss relat hospit discharg newborn definit challeng compar group dispar birth stay compar approach calcul readmiss examin year readmiss newborn versus without neonat opioid withdraw syndrom now mean length stay vs day | D010359;D010351 | T058 |
36,257,990 | structur insight tn famili transposit mechan transposon divers mobil genet element play critic role genom architect domain life tn widespread famili among first identifi bacteri transposon fame contribut dissemin antibiot resist transposit within famili mediat larg tnpa transposas facilit transposit target immun howtev structur framework requir understand mechan tnpa transposit lack describ cryo em structur tnpa tn apo form pair transposon end dna cleavag strand transfer show tnpa unusu architectur exhibit famili specif regulatori mechan involv metamorph refold rnase h like catalyt domain tnpa structur constrain doubl dimer interfac creat peculiar topolog suggest specif role target dna transpososom assembl activ | D004251;D004926 | T123;T007;T114;T086 |
36,257,989 | assess level select heavi metal pollut soil water resourc nandom district semi arid northwestern ghana studi assess heavi metal contamin soil cultiv field farm water sampl river borehol dug well nandom district semi arid northwestern ghana paramet water three sourc also measur compar permiss limit literatur result show soil farm across studi communiti signific p higher level chromium cr mgkg iron fe mgkg lead pb mgkg nickel ni mgkg arsenic mgkg compar permiss limit set world health organ food agricultur organ fao food crop water studi site signific p lower level heavi metal permiss limit set fao irrig grow crop thus water sourc appear safe irrig studi area nonetheless sourc water nandom district signific higher level total suspend solid turbid coliform maximum limit indic guidelin govern ghana drink water therefor treatment water drink requir minim potenti threat public health | D012989;D001151;D060766;D004785;D019216 | T131;T196;T121;T167 |
36,257,988 | research lung nodul recognit algorithm base deep featur fusion mkl svm ipso lung cad system provid auxiliari third parti opinion doctor improv accuraci lung nodul recognit select fusion nodul featur advanc recognit algorithm crucial improv lung cad system base hdl model paper main focus three key algorithm featur extract featur fusion nodul recognit lung cad system first cbam embed vgg vgg featur extract model ae vgg ae vgg construct network pay attent key featur inform nodul descript featur dimension reduct base pca featur fusion base cca sequenti perform extract depth featur obtain low dimension fusion featur final fusion featur input propos mkl svm ipso model base improv particl swarm optim algorithm speed train speed get global optim paramet group public dataset luna select experi result show accuraci lung nodul recognit propos lung cad system reach sensit f score reach respect reduc possibl fals detect miss detect nodul | D003074;D008175 | T047;T191 |
36,257,983 | direct experiment observ blue light induc conform chang intermolecular interact cryptochrom cryptochrom blue light receptor mediat circadian rhythm magnet sens various organ typic cryptochrom consist conserv photolyas homolog region domain vari carboxyl termin extens across speci structur flexibl carboxyl termin extens carboxyl termin extens particip cryptochrom signal function remain most unknown studi uncov potenti miss link carboxyl termin extens conform chang downstream signal function specif discov blue light induc open carboxyl termin extens c reinhardtii anim like cryptochrom structur facilit interact rhythm chloroplast circadian clock relat protein find made possibl two technic advanc use singl molecul frster reson energi transfer techniqu direct observ displac carboxyl termin extens upon blue light excit combin structur predict solut x ray scatter method propos plausibl structur full length cryptochrom dark lit condit structur provid molecular basi light activ conform chang cryptochrom downstream regulatori function | D004255;D057906 | T040;T126;T116 |
36,257,974 | trough anti xa activ intermedi dose nadroparin thrombosi prophylaxi critic ill patient covid acut kidney injuri object assess incid drug bioaccumul critic ill covid patient aki receiv intermedi dose nadroparin thrombosi prophylaxi conduct prospect cohort studi critic ill covid patient patient intermedi dose nadroparin iu daili assess incid bioaccumul trough anti xa level iuml stratifi accord presenc aki quantifi associ use multilevel analys assess robust observ explor associ aki anti xa activ patient receiv high dose nadroparin iu patient receiv intermedi dose nadroparin aki anti xa measur one patient aki ci without ci develop bioaccumul p develop aki associ mean increas ci iuml anti xa activ statist signific associ anti xa activ aki patient high dose nadroparin four major bleed event patient high dose nadroparin conclus bioaccumul intermedi dose nadroparin occur signific extent critic ill patient covid complic aki dose adjust aki may unnecessari | D000086382;D058186;D013927 | T047;T037;T067;T046 |
36,257,973 | rediscov motor relat area b emerg core hub music percept passiv listen music without sound product evid movement long known activ motor control region nevertheless exact neuroanatom correl auditori motor associ under neural mechan fulli determin base neurosynth meta analysi three origin fmri paradigm music percept show long ignor pre motor region area b anatom uniqu function intrigu region core hub music percept moreov result brain behavior correl analysi implic neural entrain under mechan area b contribut music percept view current result prior literatur area b propos keyston sensorimotor integr fundament brain machineri under simpl hierarch complex behavior refin neuroanatom physiolog understand sensorimotor integr expect major impact various field brain disord artifici general intellig | D009146;D009044 | T023;T170;T029 |
36,257,971 | biofilm antimicrobi suscept experiment evolutionari len experiment evolut experi bacteri popul repeat expos antimicrobi treatment examin genotyp phenotyp result evolv bacteria help shed light mechan behind reduc suscept review present overview import includ biofilm experiment evolut approach avail studi experiment evolut biofilm experiment evolut taught us toler resist biofilm final present emerg consensus view biofilm antimicrobi suscept support data obtain experiment evolut studi | D018441;D000900 | T121;T007;T195 |
36,257,969 | studi role slca gene biochem recurr prostat cancer prostat cancer pca common malign diseas among men biochem recurr bcr consid decis risk factor clinic recurr pca metastasi clarifi gene relat bcr possibl pathway vital provid diagnosi treatment method delay progress bcr analysi data concern pca previous dataset cancer genom atlas tcga gene express omnibus geo perform immunohistochem ihc stain use evalu express slca prostat tissu kaplan meier analysi pearson correl singl sampl gene set enrich analysi ssgsea use identifi potenti pathway molecular mechan function slca bcr pca express slca signific reduc prostat cancer cell tissu compar normal prostat epitheli cell para cancer tissu indic kaplan meier analysi high express slca could increas bcr free surviv time pca patient effect might relat interact mirna mir mir mir infiltr b cell slca novel import gene associ bcr pca studi molecular mechan may delay progress bcr | D035683;D011471 | T123;T191;T114 |
36,257,968 | generat matur human ipsc deriv organotyp cardiac microtissu long term cultur cardiovascular diseas remain lead caus death worldwid henc increas focus develop physiolog relev vitro cardiovascular tissu model suitabl studi person medicin pre clinic test despit recent advanc model reproduc tissu complex matur still limit establish scaffold free protocol generat multicellular beat human cardiac microtissu vitro hipsc name human organotyp cardiac microtissu hocmt show degre self organ cultur long term achiev differenti hipsc monolay cultur toward cardiovascular lineag follow aggreg low attach cultur dish generat hocmt contain multipl cell type physiolog compos heart beat without extern stimuli day shown hocmt display improv cardiac specif surviv metabol matur compar standard monolay cardiac differenti also confirm function hocmt respons cardioact drug long term cultur furthermor demonstr could use studi chemotherapi induc cardiotox due show tendenc self organ cellular heterogen function microtissu extend cultur time could also confirm construct human cardiac organoid hcos studi could help develop physiolog relev cardiac tissu model repres power platform futur translat research cardiovascular biolog | D057026;D002317;D000970 | T121;T025;T109 |
36,257,967 | agaros gel microcapsul enabl easi prepar picolitr scale singl cell genom yield high coverag genom sequenc novel type agaros gel microcapsul agm consist algin picolitr sol core agaros gel shell develop obtain high qualiti singl cell amplifi genom dna bacteria agm easi prepar stabl emuls oil water equival densiti prevent agm aggreg standard laboratori equip singl cell pure cultur escherichia coli mock communiti compris strain human gut bacteria termit gut bacteri communiti encapsul within agm genom dna sampl prepar massiv parallel amplif tube genom sequenc need second round amplif show averag genom complet much higher obtain use convent amplif method microlitr scale regardless genom guanin cytosin content novel method use agm allow mani research perform singl cell genom easili effect acceler genom analysi yet uncultur microorgan | D023281;D001419 | T007;T091 |
36,257,966 | reprogram myeloid cell progenitor patient non medullari thyroid carcinoma myeloid cell crucial player antitumor defens affect tumor deriv factor treatment role myeloid cell progenitor prior tumor infiltr poor understood show singl cell transcriptom function analys myeloid cell lineag patient non medullari thyroid carcinoma tc multinodular goiter treatment radioact iodin compar healthi control integr data analysi indic monocyt tc patient transcript upregul antigen present reduc cytokin product capac overproduct reactiv oxygen speci interest cancer relat patholog chang partial remov upon treatment bone marrow tc patient tend shift myelopoiesi toward lymphopoiesi reflect transcript differ taken togeth distinct transcript function chang myeloid cell aris infiltr tumor alreadi initi bone marrow suggest activ role form tumor immun microenviron | D007457;D013964 | T131;T196;T191 |
36,257,965 | hypoxia respons pathway promot pep carboxykinas gluconeogenesi c elegan activ divid cell includ cancer reli aerob glycolysi rather oxid phosphoryl generat energi phenomenon term warburg effect constitut activ hypoxia induc factor hif transcript factor known mediat adapt respons oxygen depriv hypoxia hallmark warburg effect hif thought promot glycolysi suppress oxid phosphoryl instead show hif promot gluconeogenesi use multiom approach reveal genom transcriptom metabolom landscap regul constitut activ hif c elegan use rna seq chip seq aerob condit analyz mutant lack egl key negat regul hif integr approach identifi two hundr gene direct function upregul hif includ pep carboxykinas pck rate limit mediat gluconeogenesi activ pck hif promot surviv respons oxid hypox stress work identifi function direct target hif vivo comprehens describ metabolom induc hif activ organ | D017173;D005943 | T044;T204 |
36,257,964 | autom system classif covid infect lung ct imag base machin learn deep learn techniqu object propos studi follow first object segment ct imag use k mean cluster algorithm extract region interest extract textur featur use gray level co occurr matrix glcm second object implement machin learn classifi nave bay bag reptre classifi imag two imag class name covid non covid compar perform three pre train cnn model alexnet resnet squeezenet propos machin learn classifi dataset consist covid non covid imag pre process segment propos algorithm follow featur extract process three machin learn classifi naiv bay bag reptre use classifi normal covid patient implement three pre train cnn model alexnet resnet squeezenet compar perform machin learn classifi machin learn naiv bay classifi achiev highest accuraci wherea resnet cnn model attain highest accuraci henc deep learn network outperform well compar machin learn techniqu classif covid imag | D000086382;D000077321 | T047;T066;T067 |
36,257,962 | sustain antibacteri coat graphen oxid ultrathin film combin cation surfac activ agent wet environ antimicrobi surfact contain mouthrins excel efficaci retain tooth surfac rins away due low water resist thus exhibit sustain antibacteri activ develop new coat method use graphen oxid go retain surfact tooth surfac even rins water thus provid sustain antibacteri effect ultra thin film go antimicrobi agent prepar appli go substrat surfac dri thorough rins water remov excess go form ultrathin film almost monolay transpar substrat surfac appli antimicrobi cation surfac activ agent csaa go film form composit coat film gocsaa gocsaa format verifi scan electron microscopi raman spectroscopi x ray photoelectron spectroscopi potenti contact angl measur gocsaa effect inhibit growth oral pathogen day storag water antibacteri activ recov reapplic csaa antibacteri gocsaa film also form tooth substrat result suggest gocsaa coat effect prevent oral infect | D006108;D000890 | T121;T196;T109 |
36,257,957 | protein synthesi inhibit loss homeostat function astrocyt alzheim diseas mous model role er mitochondria interact deregul protein synthesi er stressunfold protein respons er stressupr report astrocyt howev relationship protein synthesi deregul er stressupr well role alter homeostat support alzheim diseas ad astrocyt remain poor understood previous report astrocyt cell line xtg ad mice tg iastro protein synthesi impair er mitochondria distanc reduc show impair protein synthesi tg iastro associ increas p eif downregul gadd although mrna level er stressupr marker increas two three fold found neither activ perk downstream induct atf protein strike overexpress synthet er mitochondri linker eml result reduc protein synthesi augment p eif without effect er stressupr marker gene vivo hippocampi xtg ad mice reduc protein synthesi increas p eif downregul gadd protein found increas p perk atf protein observ suggest ad astrocyt vitro vivo phosphoryl eif impair protein synthesi perk independ next investig abil xtg ad astrocyt support metabol function cell central nervous system astrocyt condit medium acm tg iastro cell signific reduc protein synthesi rate primari hippocamp neuron ad part pericyteendotheli cell ec astrocyt co cultur tg iastro wt iastro sever impair format ramif tubul effect replic eml overexpress wt iastro cell final chemic chaperon phenylbutyr acid pba rescu protein synthesi p eif level tg iastro cell tubulogenesi pericyteectg iastro co cultur collect result suggest perk independ p eif associ impair protein synthesi compromis astrocyt homeostat function may caus alter er mitochondria interact | D000544;D001253 | T047;T025;T048 |
36,257,955 | rapid protein assign structur raw nmr spectra deep learn techniqu artina nuclear magnet reson nmr spectroscopi major techniqu structur biolog protein structur deposit protein data bank nmr elucid structur dynam small medium size protein solut live cell solid limit tedious data analysi process typic requir week month manual work train expert turn nmr measur protein structur autom process open problem formul field year ago present solut challeng enabl complet autom analysi protein nmr data within hour complet measur use nmr spectra protein sequenc input machin learn base method artina deliv signal posit reson assign structur strict without human intervent test protein benchmark compris multidimension nmr spectra artina demonstr abil solv structur median rmsd pdb refer identifi correct nmr reson assign artina use non expert reduc effort protein assign structur determin nmr essenti prepar sampl spectra measur | D000077321 | T066 |
36,257,954 | tmem critic structur function intercal disc mous heart intercal disc icd uniqu membran structur indispens normal heart function yet structur organ complet understood previous show icd bound transmembran protein tmem requir connexin cx local function cultur mous neonat cardiomyocyt investig function cellular effect tmem reduct myocardium mous model inject cd mous pup day birth recombin adeno associ virus raav harbor tmem shrna reduc tmem express mous ventricl compar scrambl shrna inject tmem knockdown kd result increas mortal accompani eccentr hypertroph cardiomyopathi within week inject progress dilat cardiomyopathi sever cardiac fibrosi week post inject tmem kd heart display depress hemodynam measur echocardiograph well slow conduct optic record accompani prolong pr interv qrs durat electrocardiogram immunoprecipit super resolut microscopi demonstr physic interact tmem sodium channel subunit mous heart interact appear requir establish perinex nanodomain structur local voltag gate sodium channel nav cx icd despit loss nav icd whole cell patch clamp electrophysiolog reveal reduct na current show reduc ca k current tmem kd cardiomyocyt comparison control cell conclud disrupt tmem function result impair icd structur abnorm cardiac electrophysiolog ultim cardiomyopathi | D018031;D062554 | T123;T116 |
36,257,952 | select macrocycl peptid modul lys link ubiquitin chain disrupt dna damag repair develop effect binder specif ubiquitin ub chain promis approach modul various biolog process potenti applic drug discoveri combin random non standard peptid integr discoveri rapid method chemic protein synthesi screen extend librari macrocycl peptid synthet lys link di ub discov specif binder ub chain furthermor next generat binder generat chemic modif show potent cyclic peptid cell permeabl inhibit dna damag repair lead apoptot cell death concord pulldown experi biotinyl analog lead cyclic peptid support find collect establish power strategi select inhibit protein protein interact associ lys link di ub use cyclic peptid studi offer advanc modul central ub pathway provid opportun drug discoveri area associ ub signal | D025801;D011506 | T123;T116 |
36,257,950 | effect remdesivir post hospit covid infect random solidar finland trial report first long term follow random trial nct address effect remdesivir recoveri primari outcom patient import outcom one year hospit result covid patient recruit finnish hospit surviv complet follow one year self report recoveri occur remdesivir standard care soc rr ci infer convinc differ remdesivir soc qualiti life symptom outcom p potenti long covid symptom patient report moderatemajor bother fatigu joint pain problem memori attentionconcentr conclus one year follow hospit patient one six report recov well covid result provid convinc evid remdesivir benefit wide confid interv includ possibl benefit harm | D000086382 | T047;T067 |
36,257,949 | percept memori distinct spatial tune properti human visual cortex reactiv earlier perceptu activ thought underli long term memori recal despit evid view unclear whether mnemon activ exhibit tune properti feedforward perceptu activ leverag popul recept field model parameter fmri activ human visual cortex spatial memori retriev though retinotop organ present percept memori larg systemat differ tune also evid wherea three fold declin spatial precis earli late visual area percept pattern observ memori retriev differ explain reduc signal nois poor perform memori trial instead simul top activ network model cortex demonstr properti well explain hierarch structur visual system togeth model empir result suggest comput constraint impos visual system architectur limit fidel memori reactiv sensori cortex | D014793 | T023;T029 |
36,257,947 | simpl thermodynam descript phase separ nup fg domain permeabl barrier nuclear pore complex npcs control nucleocytoplasm transport retain inert macromolecul allow facilit passag nuclear transport receptor shuttl cargo nuclei barrier describ condens phase assembl cohes fg repeat domain includ foremost charg deplet fg domain nup found nup fg domain show lcst type phase separ provid comprehens orthogon experiment dataset quantit descript behaviour deriv thermodynam model correl satur concentr repeat number temperatur ionic strength allow estim enthalpi entropi g kjmol k b contribut per repeat phase separ inter repeat cohes chang cohes strength strong impact strict barrier number provid boundari condit depth model barrier assembl also npc passag | D028861;D022022 | T026;T123;T116 |
36,257,944 | genom wide function screen drug resist gene plasmodium falciparum global spread drug resist major obstacl treatment plasmodium falciparum malaria identif drug resist gene essenti step toward solv problem drug resist report function screen new approach identifi drug resist gene p falciparum specif high coverag genom librari drug resist strain direct generat drug sensit strain resist gene identifi librari use drug screen pilot experi use strain dd known chloroquin resist gene pfcrt identifi use develop approach prove experiment concept furthermor identifi multidrug resist transport pfmdr novel candid mefloquin resist gene field isol parasit suggest upregul possibl confer mefloquin resist result show use function screen mean identifi drug resist gene | D000962;D016778 | T121;T047 |
36,257,942 | proteom effect genom wide singl gene perturb protein abund control transcript translat post translat level regulatori principl start emerg investig principl requir larg scale proteom data done transcript outcom common use proxi protein abund determin proteom chang result individu knockout nonessenti gene yeast schizosaccharomyc pomb use similar cluster global proteom chang infer gene function extend speci human baker yeast furthermor analyz select set delet mutant pair transcriptom proteom measur show upregul protein stabl transcript express util optim codon | D012568;D029702 | T004;T116 |
36,257,938 | lcat oncogen lncrna stabil igfbp cdc axi long non code rnas lncrnas known play vital role modul tumorigenesi previous report lcat novel lncrna promot growth metastasi lung cancer cell vitro vivo howev under mechan lcat oncogen regul remain elus show lcat physic interact stabil igfbp reader protein prevent degrad via autolysosom igfbp overexpress lung cancer tissu associ poor surviv non small cell lung cancer patient suggest oncogen role biolog igfbp deplet inhibit growth surviv well migrat lung cancer cell mechanist lcatigfbp complex increas level cdc key cell cycl regul stabil mrna depend manner like igfbp cdc also overexpress lung cancer tissu poor patient surviv cdc knockdown oncogen inhibitori activ taken togeth lcat igfbp cdc axi appear play vital role promot growth migrat lung cancer cell potenti therapeut target lung cancer import find also highlight previous unknown critic role lcat depend gene regul prevent autolyt degrad igfbp | D062085;D002289;D035683;D008175 | T123;T191;T114 |
36,257,937 | disrupt tenogenesi masset potenti caus micrognathia micrognathia sever craniofaci deform affect appear surviv previous studi reveal multipl factor involv osteogenesi mandibular bone contribut micrognathia concern littl factor osteogenesi current studi found ectop activ fgf osr cre presumpt mesenchym masset tendon mice led micrognathia masset regress disrupt pattern differenti masset tendon sinc myf cre rosar fgf mice exhibit normal masset mandibular bone possibl micrognathia masset regress result direct express fgf exclud investig disclos seri chondrogen marker ectop activ develop osr cre rosar fgf masset tendon mechan sens masset mandibular bone obvious reduc thus suggest micrognathia osr cre rosar fgf mice result secondarili reduc mechan forc transmit mandibular bone consist tenogen myogen compon delet develop mandibl micrognathia masset degener took place decreas mechan sens mandibular bone verifi loss mechan forc transmit masset tendon could result micrognathia furthermor appear micrognathia result disrupt tenogenesi attribut impair osteogen specif instead differenti periost progenitor find disclos novel mechan mandibular morphogenesi shed light prevent treatment micrognathia | D008844 | T019 |
36,257,936 | one year follow studi treatment compliant suicid attempt survivor relationship cypd cypc polypharmaci suicid reattempt studi cohort year treatment compliant survivor suicid attempt examin first time whether high cypd cypc metabol capac pharmacogen relat psychopatholog suicid attempt sever andor polypharmaci treatment predict repeat suicid attempt adjust sociodemograph clinic factor confound women consecut hospit patient attempt suicid evalu treat index attempt women attend month follow session clinician blind activ score genotyp calcul sum valu assign allel cypc cypd xn wtxn differ found polypharmaci prescript pattern variabl cypd cypc genotyp adher dropout former older higher frequenc anxieti bipolar disord fewer alcohol substanc use disord risk reattempt higher cypd ultrarapid metabol p violent suicid survivor p attempt occur first month period individu increas number mini dsm iv axi mental disord p second month period individu combin high cypd cypc metabol capac p increas use drug antidepress anxiolyt depress antipsychot lithium p multipl repeat period cypd cypc rapid metabol polypharmaci treatment somat comorbid must consid prevent sever side effect short term multipl suicid reattempt previous attempt | D019389;D014151 | T121;T039;T126;T116 |
36,257,935 | shank famili stem cell fate develop sh multipl ankyrin repeat domain protein shank shank shank encod famili postsynapt scaffold protein present glutamaterg synaps play crucial role synaptogenesi past year studi provid preliminari appreci understand influenc shank famili control stem cell fate review modul shank gene express relat signal pathway allow depth understand role shank stem cell besid role govern stem cell self renew prolifer differenti apoptosi metabol explor neural stem cell nscs stem cell apic papilla scap induc pluripot stem cell ipsc moreov ipsc embryon stem cell esc util model system analyz function term neuron develop shank mediat stem cell fate determin intric multifactori process studi aim achiev better understand role shank process clinic applic therebi advanc field stem cell therapi review unravel regulatori role shank famili fate stem cell | D055495;D013569 | T040;T030 |
36,257,934 | flexibl function neuron assembl support human memori episod memori conscious access memori uniqu event repres key aspect human cognit evid rodent model suggest neural represent complex memori requir cooper fire group neuron short time scale organ gamma oscil co fire group term neuron assembl repres fundament neurophysiolog unit support memori use microelectrod data neurosurg patient identifi neuron assembl human mtl show exhibit consist organ fire pattern base gamma phase inform connect properti memori perform across record session final describ human neuron assembl flexibl adjust longer time scale find provid key evid link assembl human episod memori first time | D009474;D061212 | T025;T041 |
36,257,932 | structur proteolyt enzym papp endogen inhibitor stanniocalcin reveal inhibitori mechan metzincin metalloproteinas papp play key role regul insulin like growth factor igf signal specif cleavag inhibitori igf bind protein igfbp use singl particl cryo electron microscopi cryo em report structur papp complex endogen inhibitor stanniocalcin stc neither report highest resolut obtain stc subunit n termin approxim residu papp subunit kda papp astc complex flexibl multidomain ensembl numer interdomain contact particular specif disulfid bond subunit stc papp prevent dissoci interact stc modul locat c termin end papp subunit prevent bind main substrat igfbp devoid activ toward igfbp activ site cleft catalyt domain access inhibit papp astc complex shown abil hydrolyz synthet peptid deriv igfbp relev multipl human patholog unusu mechan proteolyt inhibit may support develop specif pharmaceut agent igf signal indirect modul | D036361;D013002 | T125;T116 |
36,257,931 | synthet transcript platform programm gene express mammalian cell precis scalabl sustain control genet cellular activ mammalian cell key develop precis therapeut smart biomanufactur creat high tunabl modular versatil crispr base synthet transcript system programm control gene express cellular phenotyp mammalian cell genet circuit consist well character librari guid rnas bind motif synthet oper transcript activ addit genet regulatori element express mammalian gene high predict tunabl manner demonstr programm control report gene episom chromosom fold activ seen ef promot multipl cell type use circuit program secret human monoclon antibodi control cell effector function mark interferon product antibodi titer interferon concentr signific correl synthet promot strength provid platform program gene express cellular function divers applic | D007371;D014157 | T129;T121;T123;T116 |
36,257,921 | increas realism silico phlip peptid model novel ph gradient cphmd method ph low insert peptid phlip ph depend membran insert peptid whose function depend cell microenviron acid sever peptid variant design improv upon wt sequenc particular state transit kinet select tumor ph variant var peptid residu long peptid key titrat residu asp despit show modest perform liposom p k in excel tumor cell experi help ration result focus ph gradient cell membran one crucial properti present liposom extend cphmd l method ph replica exchang phre implement includ ph gradient mimic phlip membran microenviron cell intern ph fix ph extern ph allow chang show proper model ph gradient correct predict experiment observ loss gain perform tumor cell experi wt var sequenc respect sum ph gradient implement allow accur realist p k estim pivot step bridg silico data vivo cell experi | D008081;D018892 | T081;T044;T109 |
36,257,915 | quick pipelin isol cell cultur deriv extracellular vesicl recent advanc cell biolog research regard extracellular vesicl highlight increas demand obtain cell cultur deriv ev consid accur repres ev obtain vivo howev still grave need effici tunabl methodolog isol ev cell cultur use nanofibrillar cellulos nfc scaffold cell cultur matrix develop pipelin two differ approach ev isol cancer spheroid batch method creat deliv high ev yield end cultur period harvest method creat enabl time depend collect ev combin ev profil spheroid develop method easi set quick perform provid high ev yield compar scaffold free spheroid cultur ultra low affin plate nfc method result similar ev productioncel nfc method scalabl easier perform result high ev yield summari introduc nfc base innov pipelin acquir ev cancer spheroid tailor support need variabl ev research object | D000067128;D009369 | T026;T191 |
36,257,909 | correspond synergi antagon alloster activ site inhibitor abl tyrosin kinas soellner publish interplay alloster adenosin triphosph atp competit inhibitor abl kinas show latter prefer bind differ conform state abl compar alloster agent specif target abl myrist pocket stamp deduc asciminib bind abl simultan atp competit drug result extent line although analys dose respons matric combin asciminib imatinib nilotinib dasatinib show neither synergi antagon suggest addit antiprolif effect bcr abl depend kcl cell furthermor x ray crystallograph solut nuclear magnet reson nmr isotherm titrat calorimetri studi show asciminib bind abl concomit type atp competit inhibitor form ternari complex concomit bind asciminib imatinib nilotinib dasatinib might translat benefit chronic myeloid leukaemia patient | D047428;D000970 | T121;T116;T109 |
36,257,878 | phelan mcdermid general anesthesia differ hypnot phelan mcdermid syndrom pms rare neurodevelopment diseas caus autosom domin mutat due termin delet q lead defect shank protein present clinic case year old patient syndrom underw three intervent requir general anesthesia none present intraop postop complic | D006993;D025063 | T121;T039;T019;T047 |
36,257,876 | diagnost label advic rotat cuff diseas influenc perceiv need shoulder surgeri onlin randomis experi effect diagnost label advic interact label advic perceiv need shoulder surgeri rotat cuff diseas | D000070636;D002062 | T033;T047;T037 |
36,257,821 | quantif neutral interfaci electrostat potenti visual dispers interact visual interfaci electrostat complementar visual interfaci electrostat complementar viinec quantum chemistri base method examin protein protein interact ppi viinec electrostat complementar protein interfac visual quantit evalu use partial electrostat potenti pesp defin base fragment molecular orbit method work new quantif neutral method pesp propos togeth method visual dispers interact reliabl effici method evalu use model complex found quantif electrostat complementar pesp use new neutral method high correl interact energi support reliabl viinec illustr exampl ppi major histocompat complex class molecul cell receptor examin demonstr valu viinec chemic biolog research | D011506 | T123;T116 |
36,257,810 | three compon synthesi pyridylacet acid deriv arylationdecarboxyl substitut meldrum acid conveni simpl three compon synthesi substitut pyridylacet acid deriv report approach center dual reactiv meldrum acid deriv initi nucleophil perform substitut activ pyridin n oxid electrophil rang nucleophil trigger ring open decarboxyl | D004146 | T131;T109 |
36,257,806 | partial resect nativ prosthet arterioven fistula treatment late infect complic seri case report infect arterioven fistula av use hemodialysi hd associ massiv bleed sepsi develop format metastat infecti foci high risk av loss urgent manag infect av crucial success treatment av salvag | D001166;D001164;D000783 | T061;T046;T190 |
36,257,805 | allen master syndrom caus status ileus case report intern hernia rare encount small percentag case hernia broad ligament uterus allen master syndrom uniqu type intern hernia repres approxim intern hernia | D001956;D007415;D045823;D046449 | T023;T190;T047 |
36,257,804 | massiv intrathorac haemorrhag complic pulmonari parenchym haemorrhag anticoagul treatment lung embol covid two case report medic social interest sar cov infect current high infect sever case accompani seri complic thromboembol diseas pulmonari parenchym haemorrhag | D000086382 | T047;T067 |
36,257,803 | intrahepat cholangiocarcinoma risk factor affect surviv oper patient aim studi evalu result surgic treatment intrahepat cholangiocarcinoma ihchca term overal surviv diseas free surviv analys find potenti prognost factor affect overal surviv diseas free surviv | D001650;D018281 | T191 |
36,257,802 | middl distal bile duct carcinoma retrospect analysi short term long term outcom surgic therapi prognosi extrahepat cholangiocarcinoma dismal way achiev long term surviv surgic resect pancreatoduodenectomi pd standard procedur distal cholangiocarcinoma distal bile duct cancer dbdc bile duct segment resect bdr use altern approach middl bile duct cholangiocarcinoma middl bile duct cancer mbdc aim studi calcul short term long term outcom curat intent surgeri distal bile duct cholangiocarcinoma patient | D001650;D017734;D018281 | T023;T191 |
36,257,801 | extrahepat bile duct malign biliari tract malign belong aggress malign gastrointestin tract radic treatment surgic resect possibl limit number case due late diagnosi aim report present experi depart diagnosi treatment tumour | D017734;D001650 | T023;T191 |
36,257,800 | surgeri iatrogen bile duct injuri iatrogen bile duct injuri still repres serious complic most connect minim invas cholecystectomi complic import impact short long term morbid associ non neglig mortal object studi provid comprehens summari inform base recent guidelin recommend prevent bile duct injuri reach earli diagnosi final proceed occur order minim damag also present atom new classif bile duct injuri provid clear inform extent anatom damag also time mechan occurr | D017081;D001649;D000007 | T061;T047;T037 |
36,257,799 | surgeri extrahepat bile duct cancer current evid recommend extrahepat cholangiocarcinoma rare diseas poor prognosi requir comprehens multidisciplinari manag radic resect give hope long term surviv patient either unresect diseas condit allow radic surgeri method choic resect perihilar cholangiocarcinoma en block liver resect includ extrahepat bile duct pancreatoduodenectomi distal cholangiocarcinoma hepatopancreatoduodenectomi perform select patient entir hepato choledochus affect liver transplant neoadjuv treatment also consid high select patient unresect perihilar cholangiocarcinoma procedur technic demand associ high morbid relev mortal must concentr tertiari hepatobiliari center preoper optim bile duct drainag nutrit portal venous embol etc play crucial role reduc postop morbid mortal | D018285;D001650;D017734;D018281 | T023;T191 |
36,257,798 | current trend epidemiolog malaria malaria one world import infecti diseas occur mani tropic subtrop countri causat agent parasit protozoan genus plasmodium transmit human infect mosquito million peopl get malaria everi year worldwid hundr thousand most children year age die thank prevent programm implement various organis head world health organis aim elimin malaria case declin recent year howev particular african countri malaria continu health econom issu | D008288 | T047 |
36,257,797 | indic criteria monoclon antibodi treatment covid era vaccin updat need studi describ cohort patient receiv anti protein monoclon antibodi mab treatment covid met indic criteria set nation guidelin czech republ time author compar vaccin unvaccin subpopul cohort result show patient alreadi signific circul level anti antibodi detect time treatment author confirm posit correl number vaccin dose protein antibodi level data show vaccin patient overal less like hospit unvaccin one author recommend chang nation guidelin mab treatment czech republ | D000911;D000086382 | T129;T047;T116;T067 |
36,257,796 | unusu toxoplasma infect eye central nervous system hiv posit patient report uniqu combin cerebr toxoplasmosi ocular toxoplasmosi hiv posit patient slovakia | D015658;D015572;D014122;D014123 | T047;T195;T204;T109 |
36,257,795 | recreat pool fill miner thermal water potenti reservoir pathogen vibrio spp vibrio spp gram negat rod shape bacteria common present marin estuarin natur freshwat environ member genus associ human diseas present studi vibrio spp isol artifici recreat pool slovakia water sampl collect artifici pool fill miner thermal water eight recreat area slovakia nineti six sampl posit vibrio spp total differ strain vibrio spp isol belong potenti pathogen speci v cholera isol v vulnificus isol v furnissii isol v fluviali isol v alginolyticus isol v mimicus isol knowledg first studi demonstr presenc pathogen potenti pathogen vibrio spp artifici pool fill thermal miner water even disinfect chlorin compound | D014733;D014734 | T007 |
36,257,794 | analysi epidemiolog molecular data invas meningococc diseas surveil czech republ analysi present epidemiolog molecular data invas meningococc diseas imd surveil czech republ cr compar trend four seven year period | D009345;D008589;D022401 | T121;T129;T007;T109;T047 |
36,257,793 | risk factor affect hospitalis confirm pertussi case among infant czech republ estim risk factor affect hospitalis confirm pertussi case among infant child year czech republ base data questionnair base enhanc surveil system ess year | D014611;D014917 | T061;T047 |
36,257,786 | pharmaceut prospect biosurfact produc fungal speci develop novel type biogen surfac activ compound greater interest combat mani diseas infect respect research develop biosurfact gain immens import substanti biosurfact defin class activ amphiphil chemic compound compris hydrophob hydrophil moieti surfac general known mani kind microorgan use produc surfact surfac activ compound host interest featur biodegrad emulsifyingd emulsifi capac low toxic antimicrobi activ amphiphil compound recent year flourish ideal replac chemic synthes surfact also various commerci attract bacteria fungi produc amphiphil molecul howev pathogen certain bacteri strain caus shift interest toward fungi therefor various fungi speci report product biosurfact amongst candida speci studi strain biosurfact uphold desir properti like antibacteri antifung antivir antiadhes anticanc activ prove ideal candid applic various field like pharmaceut gene therapi medic insert safeti immunotherapi fight mani chronic diseas forth henc review articl discuss pharmaceut prospect biosurfact produc differ fungal speci provid new direct toward discoveri develop molecul novel structur divers function advanc applic medic field | D013501;D001419 | T120;T122;T007 |
36,257,763 | mil b fe cellulos microspher sorbent fulli autom dispers pipett extract toward trace sulfonamid milk sampl prior uplc msms analysi mil b fe cellulos microspher mil b fe cms character mean sem xrd tga n adsorpt desorpt test composit use sorbent fulli autom dispers pipett extract dpx introduc cms support loss mil b fe dpx avoid coupl uplc msms propos method employ analysi trace sulfonamid sas milk sampl paramet affect extract effici includ ph sampl solut rate aspir dispens amount adsorb type volum elut solvent optim optim condit good linear r five analyt high sensit limit detect g kg satisfactori recoveri achiev furthermor sorbent show desir reusabl eight extract cycl compar method pretreat sas propos method show advantag high sensit less sorbent consumpt environment friendli autom provid promis protocol sampl prepar | D053719;D000073396 | T063;T109 |
36,257,762 | improv effici entropi driven dna amplif biosens produc two label free signal strand one cycl entropi driven circuit edc provid one isotherm non enzymat signal amplif strategi effici edc signal amplif enough high one singl strand produc cycl typic edc system work propos one strategi improv amplif effici edc base biosens strategi two signal strand produc one cycl g triplex g form sequenc use signal strand gthioflavin gtht use label free fluoresc report edc base biosens detect limit method estim pm target dna time lower convent edc method furthermor respons time shorten h h word one enzym free label free edc strategi propos construct effici nucleic acid biosens platform | D015374 | T059;T075 |
36,257,761 | elev hypochlor acid level asthmat mice disclos near infrar fluoresc probe asthma respiratori inflammatori diseas serious threaten human health grow bodi evid suggest hypochlor acid hclo play instrument role inflamm relat diseas therefor hypothes may associ asthma unfortun track hclo level asthma remain challeng due lack effect measur vivo imag herein exquisit design near infrar fluoresc probe dicyanomethylen h pyran dimethylthiocarbamyl dcm dmtc explor relationship hclo asthma high sensit time low limit detect nm great select hclo addit probe dcm dmtc success employ trace exogen endogen hclo live cell notabl higher level hclo lung asthmat mice normal mice visual fluoresc imag first time indic remark intim associ asthma overproduct hclo | D006997;D001249 | T047;T196;T197 |
36,257,760 | magnet relax switch fluoresc dual mode biosensor rapid sensit detect ricin b toxin edibl oil tap water ultrasensit rapid detect ricin b toxin rtb essenti food safeti environment monitor herein dual mode magnet relax switch mrs fluoresc fl biosens strategi develop effici detect rtb use fluoresc magnet nanoparticl mnp sio fitc meanwhil prepar composit mnp sio fitc exhibit superior biocompat increas fl readout coupl aptam apt form captur probe magnet nanoparticl nm diamet mnp coupl blocker form pair probe compet rtb apt bind presenc rtb trigger dual mode detect switch thus weaken magnet fluoresc signal compar singl mode detect method fl intens exhibit excel linear relationship logarithm rtb concentr ngml ngml obtain ultrahigh sensit pgml pgml respect addit dual mode biosensor gain satisfactori spike recoveri relat standard deviat quantit detect spike rtb edibl oil tap water sampl knowledg first studi describ accur quantif rtb use sensit mrs fl biosensor anticip strategi provid novel avenu develop dual mode sens assay | D012276;D015374 | T131;T059;T116;T075 |
36,257,759 | metabolog analysi metabolom data use communiti ecolog tool sever area microbiolog botani medicin use genet inform comput tool organ classifi analyz data howev recent possibl obtain chemic ontolog metabolit comput systemat classif metabolit class open way adapt method previous use genet taxonomi accept chemic ontolog communiti ecolog tool ideal adapt matur method enabl exploratori data analysi establish statist tool studi introduc metabolog approach transform metabolit ecosystem metabolit speci relat chemic ontolog present work demonstr applic new approach use public avail data metabolom studi human plasma search prognost marker covid untarget metabolom studi carri laboratori use lasiodiplodia theobroma fungal pathogen supernat | D017753;D000086382 | T067;T047;T070;T082 |
36,257,758 | construct revers enol keto enol tautomer coval organ polym sensit select multi channel detect iron iii import element organ lack excess ferric ion fe may lead extens rang diseas present distinct clinic manifest design multi channel probe revers enol keto enol tautomer specif recognit high sensit detect fe prepar paper report novel cop nc probe tris formylphenyl amin bear cyclohexanedion group provid bind site fe also contribut fluoresc electrochem signal synthes cop nc exhibit intens fluoresc excit wavelength nm quantum yield result spectroscop measur show fe signific caus switch fluoresc intens effect simultan addit fe caus switch effect electrochem channel realiz detect fe concentr low nm fluoresc channel redox channel respect develop joint probe multi channel signal provid conveni rapid detect method food medic treatment environment monitor field | D007501;D011108 | T123;T121;T104;T196;T122 |
36,257,757 | simpl versatil strategi sensit sida uhplc msms analysi alternaria toxin oliv oil alternaria toxin natur occur contamin found natur product given preval alternaria toxin complex oil rich matric achiev ultra trace analysi becom daunt task new sampl pretreat techniqu ie cold induc liquid liquid microextract combin serial coupl column sida uhplc msms develop report first time theoret experiment investig mechan key paramet reveal propos method achiev simultan purif enrich one step sampl extract superior limit quantit g kg without sampl manipul fat remov solvent exchang procedur prior lc ms method valid take consider eu guidelin show accept linear r accuraci recoveri precis rsd analyt studi success appli analysi twenti sampl sourc mediterranean region order gain first insight alternaria toxin contamin oliv oil technic approach well suit larg scale studi high throughput cost effect qualiti assur laboratori environ potenti detect ultra trace level toxin complex sampl may lead develop new sustain sampl prepar procedur | D009183;D014118;D001688 | T131;T121;T123;T109 |
36,257,756 | univers platform accur damag free map sev cargo inform sev small extracellular vesicl content signatur appear mirror patholog chang diseas map sev content profil promis approach non invas diagnosi diseas herein propos univers system accur damag freeli map sev content profil use dual recognit trigger cha catalyt hairpin assembl dnazym base signal amplif strategi immunoassay base captur cd posit sev anti cd lgg coat surfac polystyren plate probe incub fix sev penetr sev membran act sens sev content detect step integr cha dnazym base strategi initi releas initi captur probe recogn target form dual circl signal recycl process realiz signal amplif high sensit given attract analyt featur univers platform indistinct sev nucleic acid protein molecul detect ii high sensit deriv dual circl signal recycl process iii enzym free characterist integr cha dnazym minim interfer sev biolog activ iv map sev content profil indic brand new strategi non invas diagnosi diseas present approach show great promis analyz addit differ analyt clinic experiment research | D021881;D000067128;D015374 | T026;T116;T075;T059;T126;T114 |
36,257,755 | segment msms acquisit ion base strategi depth proteom quantit depth proteom quantit great signific understand protein function advanc biolog medic environment metabol engin research herein benefit high format effici intens dimethyl label ion accur quantit develop depth ion base proteom quantit method name deep apq sequenti msms acquisit high mass rang identif low mass rang ion intens extract increas quantit protein number sequenc coverag analysi hela protein digest develop method show deeper quantit coverag previous report ion base quantit method without mass rang segment lower miss valu wide use label free quantit method also exhibit excel accuraci precis within fold dynam rang integr workflow combin deep apq method high effici sampl prepar high ph low ph revers phase separ high field asymmetr waveform ion mobil spectrometri faim studi e coli proteom respons nutrit condit glucos acet total protein quantifi repres protein code gene averag sequenc coverag demonstr high coverag quantit result found quantifi protein relat chemotaxi differenti express includ low abund protein tap trg aer chea cheb indic chemotaxi would play import role e coli cell surviv acet toxic result demonstr deep apq method great promis achiev deep coverag proteom quantit high confid | D020543;D053719 | T063;T123;T116 |
36,257,754 | analysi trace phytoavail heavi metal salin soil extract one step electroextract coupl situ desorpt microplasma optic emiss spectrometri site sensit analysi phytoavail heavi metal key fast evalu pollut incid develop conveni effici sampl introduct approach matrix interfer crucial improv perform field deploy instrument herein trace phytoavail heavi metal soil first extract nano afterward adsorb onto activ carbon tip via electroextract ee final analyz dielectr barrier discharg dbd microplasma optic emiss spectrometri oe via situ desorpt activ carbon tip abl extract heavi metal alkali metalsalkalin earth metal matrix resist interfer coexist anion non electroact speci salin soil extract also signific improv detect sensit subsequ dbd oe analysi increas load amount analyt take key heavi metal pollut model detect limit cd zn cu pb reach g kg respect precis within accuraci practic present miniatur ee dbd oe devic verifi measur sever certifi refer materi real soil sampl provid promis tool conveni sensit analysi trace phytoavail heavi metal soil | D019216;D014131;D012989;D008672 | T123;T196;T121;T131 |
36,257,753 | high select ser detect acetylcholinesteras human blood base catalyt reaction acetylcholinesteras ach key hydrolas cholinerg system direct determin degrad neurotransmitt therefor signific challeng detect ach human blood high sensit select physiolog patholog process novel nanoprob decor surfac gold nanoparticl neostigmin ne aunpsn construct ach assay serum principl base specif recognit cleavag carbam bond aunpsn ach form hydroxyl group result chang ser spectra result show nm aunpsn exhibit excel catalyt activ reaction reaction rate six time higher nm aunpsn benefit combin advantag catalyt reaction specif molecular finger print provid ser technolog aunpsn exhibit high select ach limit detect lod method ach activ low uml addit spike recoveri ach serum sampl propos sensor also exhibit long term stabil high biocompat increas incub time import work provid new perspect elucid role ach regul oxid stress patholog depress | D006046;D053768 | T121;T196;T073 |
36,257,752 | cu nanoclust decor ti c nanosheet composit tetraenzym mimic activ applic smartphon assist detect hypoxanthin mxene base nanozym increas research enthusiasm field food safeti environ monitor herein cu ncsti c nss nanocomposit prepar modifi copper nanoclust cu ncs surfac ti c nanosheet nss simpl two step method cu ncsti c nss nanocomposit outstand tetraenzym mimic activ ie peroxidas pod mimic catalas cat mimic ascorb acid oxidas aao mimic superoxid dismutas sod mimic modif cu ncs ti c nss enhanc tetraenzym mimic activ synergist catalyt effect cu ncs ti c nss catalyt mechan steadi state kinet cu ncsti c nss also investig base pod mimic activ cu ncsti c nss simpl rapid colorimetr method establish site detect hypoxanthin hx linear rang limit detect lod visibl color chang increas hx concentr recogn smartphon app transfer red r green g blue b valu quantit analysi hx linear rang provid conveni method real time detect hx work provid signific rout fabric nanocomposit outstand tetraenzym mimic activ also offer low cost rapid method monitor fresh aquat product | D003300;D015374 | T123;T121;T075;T196;T059 |
36,257,751 | high sensit easi rapid fabric microfluid electrochem cell enhanc three dimension electr field np fec reusabl novel microfluid electrochem cell multipl non planar interdigit microelectrod array minim sampl volum enhanc electr field penetr high sensit electrochem analysi np fec featur spatial electrod architectur small sampl volum l ii fe cn redox coupl use electrochem report effect electrochem properti np fec due chang refer electrod counter electrod ce posit respect work electrod posit analyz np fec posit respect affect cv dpv electrochem profil howev space ce play signific role iii enhanc three dimension electr field penetr np fec valid finit element analysi simul use comsol multiphys iv without electrod surfac modif np fec show detect limit dl aqueous fe cn probe v dl cu fe hg g l g l g l respect meet us environment protect agenc epa water contamin level cu fe close hg epa limit g l g l g l respect vi use pressur sensit adhes layer form channel creat np fec configur simplifi manufactur process make cost effect allow rapid adopt research lab np fec use detect heavi metal ion water demonstr cost effect easi fabric np fec new sensit electrochem platform | D019216;D008628 | T131;T196 |
36,257,750 | molecular email electrochem aptasens fish pathogen molecular inform encod encrypt hide applic dna data encod molecular recognit rare use combin electrochemistri multipurpos integr applic especi sens inform communic secur herein demonstr electrochem aptasens inform communic safeti system detect fish pathogen aeromona hydrophila edwardsiella tarda molecular inform encrypt hide two fish pathogen easili quick detect electrochemistri respect high select sensit detect limit lower cfuml without need tradit time consum biochem cultur process specif interact probe dna aptam target pathogen tini impercept electrochem platform provid protect hide dna aptam contain encod messag also offer foundat develop molecular cryptographi steganographi electrochem system similar mail communic record inform paper molecular mail record inform dna read inform use electrochem sens precis molecular electrochem mail name molecular email studi prove combin recognit encod capabl dna aptam electrochemistri open new door molecular level digit technolog futur larg capac easi oper resett flexibl molecular crypto steganographi develop molecular cascad communic control | D052157;D015374 | T075;T059;T114 |
36,257,749 | silver modifi nitrogen dope graphen quantum dot sensor formaldehyd milk use headspac micro extract singl drop aqueous nanoparticl dispers fraudul practic use distort qualiti milk deriv includ addit formaldehyd | D006108;D045663 | T196;T073;T109 |
36,257,748 | con support co n metal cluster develop sensit chemiluminesc immunochromatograph assay view optim catalyt effici singl atom site catalyst wide exploit rang area includ organ synthesi energi convers environment remedi biotherapi etc howev low load ratio unitari activ site singl atom site catalyst dramat hinder remark improv catalyt activ herebi facil low temperatur reduct protocol adopt synthes con support co n metal cluster graphit carbon nitrid show remark superior chemiluminesc cl catalyt capac report pure singl atom site catalyst nitrogen encapsul co n cluster coupl isol co n moieti co n co n endow synerget catalyst high co content wt x ray absorpt spectroscopi synerget activ site co n co n afford con support co n cluster remark catalyt activ acceler decomposit h produc extens superoxid radic anion rather singlet oxygen hydroxyl radic therefor con support co n cluster possess superb enhanc effect luminol h cl reaction time con support co n cluster util signal probe establish cl immunochromatograph assay ica platform quantit mycotoxin herein aflatoxin b employ mode analyt limit detect low pg ml proof principl work develop ica protocol success employ detect aflatoxin b spike angelica dahurica ganoderma lucidum accept recoveri ideal practic work elucid con support co n cluster show new perspect develop sensit cl biosens | D008165;D017665 | T197;T130;T109 |
36,257,747 | carbon fiber paper spray ionize mass spectrometri carbon fiber paper cfp common use proton exchang membran fuel cell due promin areal electrosorpt capac except conduct excel chemic stabil paper first explor feasibl carbon fiber paper specif paper substrat paper spray ionize mass spectrometri psi ms result demonstr cfpsi ms combin merit psi carbon fiber ionize cfi exhibit better perform various compound analys either techniqu alon applic cfp high enhanc signal stabil detect sensit divers array analyt especi negat ionize mode ion intens target analyt saccharid flavonoid improv fold mani nonpolarlow polar analyt polycycl aromat hydrocarbon difficult ioniz tradit psi ms success detect cfpsi ms kv high voltag moreov cfpsi ms present high sensit semiquantit analysi limit detect lod cyclic adenosin monophosph camp naringin tivantinib whole blood improv fold compar tradit psi ms real sampl analysi cfpsi ms also exhibit excel capabl human breath analysi blood metabolom profil | D011522;D011084 | T196;T109 |
36,257,746 | carbon dot modifiedprepar supramolecular host molecul potenti applic review supramolecular host molecul use tool design multifunct nanoparticl sensor catalyst biometr element etc combin carbon dot cds excel host guest recognit properti fluoresc characterist precis captur identifi target analyt consequ supramolecular host molecul base cds signific improv detect perform ion molecul differ structur intrins chemic properti current respond wide rang analyt includ metal cation anion organ compound biomolecul yield fascin achiev field chemistri therefor present review summar outstand supramolecular host molecul base cds report past ten year focus elucid mechan methodolog advantag disadvantag modifi prepar cds supramolecular host molecul current challeng encount outlook also discuss | D002244;D045663 | T121;T196;T073 |
36,257,745 | fe dope induc surfac fe fe cycl activ redox inert tio enhanc hg ii electrochem sens effici strategi strengthen redox activ recent fe base metal oxid variabl valenc abil ie fe fe cycl particip redox target heavi metal ion hmis enhanc electrochem signal attract signific attent howev yet prove whether iron base metal oxid variabl valenc abil activ variabl valenc behavior inert metal oxid ie tio enabl particip redox target hmis herein develop effici fe dope strategi activ tio nanoparticl electrochem detect hg ii tio nanoparticl fe dope content ft possess best detect sensit cm hg ii dramat higher pure tio synergist effect enhanc adsorpt ov promot redox activ surfac fe fe ti ti cycl help ft obtain excel electrochem detect perform hg ii detail fe dope tune concentr oxygen vacanc ov tio nanoparticl contribut improv adsorpt abil hg ii expos ov surfac fe dope tio nanoparticl form numer hydroxyl group oh water hydroxyl group bond hg ii tremend acceler captur hg ii upon success obtain ov ti speci creat tio achiev activ tio moreov found larg amount surfac fe fe ti ti cycl ft acceler redox hg ii favor electrochem detect perform studi emphas dope transit metal element variabl valenc state control ov concentr success activ inert metal oxid | D019216;D008628 | T131;T196 |
36,257,744 | aptasensor cadmium ion detect base pei mos au nps flower like nanocomposit thi ptpd nps core shell sphere novel ultrasensit electrochem aptasensor propos quantit detect cd end flower like polyethyleneimin function molybdenum disulfid support gold nanoparticl pei mos nfs au nps use substrat modif bare gold electrod aue pei mos nfs au nps possess excel biocompat larg specif surfac area enhanc cdna load capac also possess good conduct acceler electron transfer rate furthermor prepar dendrit platinum palladium nanoparticl ptpd nps effect load cd aptam thionin aptam load onto ptpd nps construct thi ptpd nps aptam signal probe signal probe captur cdna immobil electrod via base pair rule signal thi detect differenti puls voltammetri dpv presenc cd aptam cdna unwind combin aptam cd caus signal probe fall electrod electr signal decreas optim condit propos aptasensor exhibit linear relationship logarithm cd concentr current respons wide rang nm nm detect limit nm time aptasensor use detect cd tap water satisfactori result addit good reproduc select stabil broad applic prospect heavi metal analysi | D053768;D052157;D015374;D053761 | T075;T059;T073;T114 |
36,257,743 | near infrar fluoresc probe larg stoke shift bioimag galactosidas live cell zebrafish develop differ period overexpress galactosidas gal tumor cell may serv valuabl biomark earli diagnosi cancer ovarian cancer addit abnorm accumul gal also consid essenti marker cell senesc therefor import construct fluoresc probe excel fluoresc properti visual gal biolog system design screen novel fluoresc probe xm detect gal spectral data show probe good affin k gal larg stoke shift nm fast respons speed stabl within min low detect limit uml base advantag xm detect gal content cancer cell also track chang gal content zebrafish differ development period believ xm becom power tool earli cancer diagnosi cellular senesc | D005456;D015027 | T130;T013 |
36,257,742 | smartphon integr dual emiss fluoresc sens platform base carbon dot aluminum ion trigger aggreg induc emiss copper nanoclust site visual detect sulfur ion ratiometr fluoresc strategi propos base carbon dot cds self assembl copper nanoclust cunc driven al ion detect si cdscunc al exhibit blue red emiss singl excit interest red emiss cunc regular quench blue fluoresc emiss cds preserv continu addit fluoresc spectromet base linear rang low detect limit lod fluoresc respons si cdscunc al exhibit distinct color chang process red pink blue impli feasibl visual analysi portabl fluoresc sens platform establish use color valu convers function smartphon accur visual quantit identif without spectromet fluoresc test strip prepar si cdscunc al conduct site visual analysi water environ conveni quick linear rang detect base smartphon integr test strip sens platform lod work provid new horizon target site analysi environment sampl | D003300;D045663 | T123;T196;T121;T073 |
36,257,741 | label free de conjug free workflow simultan quantifi trace amount freeconjug protein bound estrogen metabolit human serum differ chemic form sex hormon includ freeconjug metabolit well proteindna adduct human serum panel import indic health condit howev hard quantifi speci simultan due lack general extract derivat de conjug method develop label free de conjug free workflow quantifi freeconjug estrogen metabolit includ depurin dna protein adduct form hydroxyestradiol ohe human serum acetonitril act excel solvent purifi adduct non adduct human serum albumin hsa precipit well extract freeconjug metabolit depurin dna adduct supernat salt effect adduct level ohe hsa determin proteom freeconjug metabolit quantifi newli develop microflow liquid chromatographi microflow lc nanoelectrospray ionize nanoesi multipl reaction monitor mrm method high reproduc rsd n sub picogram level pgml quantif limit sn use non pull capillari nano esi emitt workflow demonstr reveal endogen adduct level ohe hsa well circul level freeconjug metabolit clinic sampl ohe human serum sole detect protein bound form indic merit integr platform cover unstabl activ metabolit compar tradit method use label de conjug reaction workflow much simplier sensit specif moreov wide appli omic concurr access various bio transform known un known marker drug | D018736;D004966 | T123;T121;T109;T114;T125 |
36,257,740 | fabric novel electrochem immunosensor sensit detect carcinoembryon antigen use doubl signal attenu strategi carcinoembryon antigen cea acid protein characterist antigen produc tumor various cancer eg breast cervic rectal lung etc therefor detect cancer antigen import earli diagnosi treatment cancer studi novel signal strategi electrochem immunosensor develop detect cea end prussian blue nanoparticl pb nps electroact substanc use immunolog platform addit cuo sio nanocomposit releas cu h acid condit synthes generat cu replac high spin iron fe iii pb nps turn reduc oxid peak current pb nps due peroxidas like natur pb nps react self generat h generat hydroxyl radic oh convert chloro naphthol cn non conduct polym accumul electrod surfac lead reduct electr signal pb nps moreov self generat cu h reduc introduct exogen substanc improv detect accuraci squar wave voltammetri swv reveal electr signal pb nps gradual decreas increas cea concentr addit electr signal pb nps exhibit good linear rang pg ml ng ml logarithm cea concentr detect limit low pg ml | D015374;D053768 | T059;T073;T075 |
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