PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,257,063 | tune pack densiti gold nanoparticl peptoid nanosheet prepar oil water interfac two dimension array gold nanoparticl freeli float water promis materi solut base plasmon applic like sens effect sensor critic control interparticl gap distanc thus plasmon properti array demonstr excel control interparticl gap distanc famili freeli float gold nanoparticl embed peptoid nanosheet nanosheet made via monolay assembl collaps oil water interfac allow fine control solut nanoparticl concentr assembl use surfac pressur measur monitor assembl peptoid nanoparticl combin system oil water interfac determin workabl rang nanosheet assembl condit suitabl control interparticl gap distanc within nanosheet measur reveal extent nanoparticl adsorpt peptoid monolay tune vari bulk nanoparticl concentr abil monolay collaps nanosheet compromis high nanoparticl concentr peptoid nanosheet synthes vari bulk nanoparticl concentr analyz use light microscopi uv visibl spectroscopi base spectral shift local surfac plasmon reson peak nanoparticl nanosheet relat well dispers toluen estim access interparticl gap distanc within nanosheet interior nm result suggest minimum interparticl distanc achiev method limit nanoparticl ligand length potenti tune vari ligand chemic structur abil quantit control monitor assembl condit method provid opportun readili tune optoelectron properti new class nanomateri make promis platform plasmon base sens applic | D034444;D053768 | T116;T073 |
36,257,062 | enhanc clinic diagnosi patient persist pulmonari abnorm covid infect potenti benefit ga fapi petct six post covid patient suspect pulmonari fibrosi schedul dual tracer petct f fdg ga fibroblast activ protein inhibitor fapi uptak ga fapi involv lung compar control group non covid patient clinic data petct imag collect analyz | D000072078;D000086382 | T060;T047;T067 |
36,257,060 | structur uptak relationship studi oxazolidinon gram negat eskap pathogen clinic success linezolid treat gram posit infect pair high conserv bacteri ribosom predict oxazolidinon engin accumul gram negat bacteria pharmacolog class would find broad util erad infect report investig studi strateg design librari oxazolidinon determin effect molecular structur accumul biolog activ escherichia coli acinetobact baumannii pseudomona aeruginosa strain vari degre compromis efflux outer membran use identifi motif hinder permeat across outer membran andor enhanc efflux suscept broad specif speci result illustr small chang molecular structur enough overcom efflux andor permeat issu scaffold three oxazolidinon analogu e identifi exhibit activ three pathogen assess biolog profil observ linezolid | D023303 | T109 |
36,257,059 | improv synthes vinylbenzo n crown n ether n conveni high yield scalabl synthet approach construct vinylbenzocrown ether develop employ decarboxyl cyclize strategi use method wide rang class vinylbenzocrown ether effici obtain ident crown ether establish use singl crystal x ray diffract studi two vinylbenzocrown ether crystal water afford infinit supramolecular assembl contain hydrogen bond water molecul | D043844 | T109 |
36,257,056 | isol character heterolept mononuclear palladium complex catalyt transform involv pd pd ii catalyt cycl well known process involv high valent pd iii pd iv low valent pd intermedi also gain interest recent year although low valent pd intermedi propos catalyt cycl isol character mononuclear pd speci rare herein report isol two heterolept mononuclear pd complex stabil dithiapyridinophan ligand fulli character singl crystal x ray diffract epr ir uv vis spectroscopi comput studi excit one pd complex show kumada csp csp cross coupl compet initi studi show direct evid csp h bond activ propos occur pd center | D010165 | T196 |
36,257,052 | orthogon enzym driven timer dna strand displac reaction demonstr strategi ration program delay onset toehold mediat dna strand displac reaction sdrs approach base blocker strand effici inhibit strand displac bind toehold domain target dna specif enzymat degrad blocker strand subsequ enabl sdr kinet blocker enzymat degrad thus control time sdr start vari concentr blocker strand concentr enzym show fine tune modul delay onset sdr addit show strategi versatil orthogon control differ enzym specif target differ blocker strand design establish three differ delay sdrs use rnase h two dna repair enzym formamidopyrimidin dna glycosylas uracil dna glycosylas correspond blocker achiev tempor delay program high flexibl without undesir leak conveni predict use kinet model final show three possibl applic delay sdrs tempor control ligand releas dna nanodevic inhibit target protein dna aptam output signal generat dna logic circuit | D004247;D052157 | T123;T114 |
36,257,024 | insight adsorpt drug load silica aerogel supercrit co work give insight process adsorpt drug load silica aerogel supercrit co scco preval method load entail bring aerogel contact drug scco solut follow slow isotherm depressur previous work establish drug precipit depressur consequ adsorpt drug load measur preval method includ precipit altern method present accur measur adsorpt avoid precipit illustr dispar two method concentr depend drug load scco obtain method compar fenofibr ibuprofen benzoic acid mechan propos mathemat model develop compar adsorpt drug load method load obtain present method found much less preval method though correl well formal langmuir adsorpt equat equilibrium constant low concentr equat develop concentr depend drug load measur method concentr scco | D012822;D011345 | T121;T197;T109 |
36,257,022 | exploit sequenc depend rotam inform global optim protein rotam name amino acid side chain conform common mani differ peptid compil librari rotam librari use protein model limit conform space occupi amino acid side chain exploit construct sequenc depend rotam librari simul possibl tripeptid provid rotamer state depend adjac amino acid observ signific sensit rotam popul sequenc find librari success locat side chain conform present crystal structur librari design applic basin hop global optim use propos move conform space addit rotam move signific increas effici protein structur predict within framework determin paramet optim effici | D011506;D000596 | T123;T121;T116 |
36,257,013 | post traumat stress disord covid intens care admiss characterist perspect increas psychopatholog post traumat stress disord ptsd describ patient affect covid stay intens care unit icu howev data follow impact contextu factor limit singl center observ studi ptsd symptomatolog preval among particip n persist clinic ptsd particip one year patient initi ptsd symptom score depress anxieti insomnia scale signific higher higher mental burden due avoid contact reduc qualiti life also retain patient ptsd symptom | D013313;D000086382 | T047;T067;T048 |
36,257,012 | psycholog analysi network rumor spread covid epidem sinc outbreak covid epidem relat rumor spread rapid social media serious affect public normal life caus mental panic anxieti paper analyz spread onlin rumor impact public mental health covid epidem aim put forward relev suggest deal rumor improv public mental health | D000086382;D058872;D061108 | T047;T170;T067 |
36,257,011 | challeng caregiv children autism spectrum disord comorbid covid pandem serbia children autism spectrum disord asd experi signific higher preval mental disord amplifi need overal support outbreak novel coronavirus covid result restrict limit access differ servic great challeng famili children asd | D000067877;D000086382 | T047;T067;T048 |
36,257,010 | posit post traumat stress disord ptsd covid survivor mediat role rumin fear covid covid pandem still continu affect whole world led increas ptsd symptom societi especi individu diagnos diseas recov signific risk ptsd report although observ ptsd symptom individu infect past epidem sar ebola continu long time even epidem noteworthi studi conduct covid process focus enough peopl surviv covid diseas purpos studi determin direct indirect impact posit ptsd symptom individu recov covid role rumin fear covid potenti mediat effect | D000086382;D013313 | T047;T067;T048 |
36,257,009 | prognost assess stress relat factor healthcar worker covid pandem covid pandem extraordinari challeng countri affect psycholog wellb healthcar profession work peopl suffer covid put high risk mental health problem aim studi identifi stress relat factor affect mental health healthcar worker covid pandem ukrain | D000086382;D006282 | T047;T097;T067 |
36,257,008 | mental health support program healthcar profession pandem hospit turkey result anxieti depress insomnia sexual disord covid pandem put enorm stress health care worker threaten physic health also mental well mental health support program mhsp address depress anxieti healthcar worker hcws shown effect turkey previous aim measur effect mhsp among healthcar worker appli psycholog help associ covid pandem | D000086382;D007319 | T184;T047;T067;T048 |
36,257,007 | fight fall rais impact covid pandem mental health health care provid covid pandem health care provid found increas demand work environ profession person live creat physic mental health challeng thus aim provid integr review identifi summar research publish regard mental health function health care provid serbia sinc begin pandem | D058873;D000086382 | T047;T067 |
36,257,006 | empathi healthcar profession coronavirus pandem empathi import success interact aim present studi determin whether cognit compon perspect take affect compon empath concern person distress empathi health profession relat degre perceiv threat coronavirus difficulti work difficulti get along peopl health condit current past coronavirus diseas well socio demograph characterist fantasi cognit compon empathi focus present studi irrelev clinic practic | D004645;D000086382;D006282 | T067;T055;T097;T054;T047 |
36,257,005 | impact covid ect practic qatar pauciti electroconvuls therapi ect util survey arabian gulf region none avail qatar literatur avail impact coronavirus diseas covid pandem ect provis ect lifesav treatment psychiatr practic requir anesthet support concern redeploy anesthetist due covid pandem might compar bigger impact provis ect concern stem fact psychiatr patient often get discrimin health care system larg due stigma belief among healthcar provid psychiatr ill somehow serious type medic surgic ill brief report present pre covid ect util qatar also report find ect util covid compar chang elect non elect surgeri ect provis march august set declin ect provis compar elect non elect surgeri | D004565;D000086382;D001523 | T061;T047;T067;T048 |
36,257,004 | incid alcohol use disord covid pandem covid pandem introduc myriad challeng healthcar system public health polici across globe individu alcohol use disord peak risk due mental socio demograph econom factor lead hinder mental health servic access misinform adher | D000086382;D000437 | T047;T067;T048 |
36,256,988 | effect famili constel therapi reduc psychopatholog symptom naturalist set aim studi clinicaltrialsgov identifi nct provid evid effect safeti familysystem constel therapi wide use rare investig form brief group psychotherapi | D015928 | T061 |
36,256,987 | effect social psycholog intervent self efficaci social adapt qualiti life internet addict teenag internet addict lead psycholog social damag teenag rehabilit treatment internet addict adolesc arous widespread concern studi aim explor effect social psycholog intervent self efficaci social adapt qualiti life internet addict teenag | D016739;D011788 | T078;T048 |
36,256,986 | alexithymia facebook addict beyond role patholog narciss person dysfunct deficit capac cope negat emot state relat internet addict howev relat facebook addict issu remain poor investig specif studi explor role play grandios vulner narciss facebook addict furthermor relationship alexithymia patholog narciss yet explor relat problemat facebook use main object studi examin associ among facebook addict patholog narciss alexithymia | D061108;D016739 | T170;T048 |
36,256,985 | depress loneli mediat social support mobil phone addict mobil phone addict among adolesc attract lot attent recent year previous research reveal signific relat low social support addict studi aim investig associ social support mobil phone addict mediat effect depress loneli | D008132;D040421 | T033;T073 |
36,256,984 | cross section studi psychiatr comorbid croatian homeland war veteran held prison war affect posttraumat stress disord extrem traumat experi captiv may caus mental disord addit posttraumat stress disord high preval among ex prison war often occur comorbid least one mental disord object studi identifi incid comorbid mental disord homeland war veteran ex prison war affect posttraumat stress disord well identifi factor influenc psychiatr comorbid | D014728;D013313;D063906;D011329 | T098;T048 |
36,256,983 | predictor chronic combat relat post traumat stress disord group psychotherapi favor outcom prospect cohort studi croatia combat relat chronic post traumat stress disord ptsd therapeut resist disord fluctuat cours success group psychotherapi partial aim paper determin baselin characterist veteran group psychotherapi effect psychotherapeut treatment | D013313;D014728;D011615;D003130 | T061;T047;T098;T048 |
36,256,982 | stuck moment tonic immobl predict poor qualiti life treat ptsd patient posttraumat stress disord ptsd preval disabl multisystem disord signific physic psychiatr morbid poor qualiti life qol although peritraumat reaction tonic immobl dissoci establish predictor ptsd sever develop dearth investig assess impact peritraumat reaction qol ptsd patient qualiti life becom increas import health care research reliabl outcom measur compris psycholog physic social environment domain provid import inform impact diseas patient life studi aim investig impact peritraumat tonic immobl peritraumat dissoci qol ptsd civilian outpati | D013313 | T048 |
36,256,981 | presenc minor physic anomali hand patient mental disord minor physic anomali mpa subtl morpholog deviat littl none clinic signific develop prenat therefor could indic structur chang brain develop time aim studi determin whether mpa hand distinguish psychot patient patient non psychot diagnos well healthi individu | D011618;D012559 | T048 |
36,256,980 | interconnect mix handed digit ratio hand foot minor anomali predict schizophrenia accord neurodevelopment theori brain structur earli marker could seen differ bodi part minor physic anomali alongsid minor physic anomali handed index ring finger ratio brain develop indic specif brain later studi consenti associ find schizophrenia though inconsist individu anatom region contribut propos handed combin morpholog indic earli brain develop could sensit specif predict schizophrenia status | D012559 | T048 |
36,256,975 | reflect complex histori concept clozapin induc inflamm titrat clozapin synthes food drug administr approv comprehens pharmacokinet studi requir known clozapin metabol cytochrom p cypa current known clozapin person dose may influenc one dna ancestri african european andor asianindigen american sexsmok subgroup presenceabs geneticnon genet poor metabol pm status literatur proper reflect concept clozapin induc inflamm rapid titrat elabor upon concept histor review discuss clozapin induc fever effect inflamm clozapin metabol clozapin induc myocard clozapin induc inflamm current support clozapin induc inflamm hypersensit reaction difficulti address concept readership divers belief limit review convinc skeptic clozapin induc fever absenc concomit infect first describ mild form clozapin induc inflamm rapid titrat also includ myocard local inflamm may part hypersensit reaction phase first phase titrat fast specif patient either psychiatrist aggress titrat andor patient clozapin pm situat lead releas cytokin second phase posit feedback loop develop cytokin inhibit cypa increas plasma clozapin concentr third phase titrat continu inflamm becom complic develop auto immun phenomenon lead local inflamm skeptic reader challeng tri titrat propos stratifi dose c reactiv protein crp monitor person dose absenc genet test clozapin pm status | D003024;D014150;D009205 | T047;T121;T039;T109 |
36,256,974 | phenomenolog non ordinari logic brief strateg therapi brief strateg therapi bst psychosoci treatment mental disord base uniqu theori psycholog dysfunct differ major psychotherapi approach psycholog dysfunct follow non ordinari logic rather classic logic principl bst contend three differ kind non ordinari logic underpin psycholog dysfunct logic contradict logic paradox logic belief bst therapeut strategi base non ordinari logic process unfortun descript case exampl non ordinari logic scatter among myriad book difficult clinician get acquaint addit bst literatur describ non ordinari logic somewhat obscur metaphor languag might difficult clinician grasp herein condens descript case exampl three non ordinari logic clarifi phenomenolog process class non ordinari logic highlight research find differ theoret orient coher consist phenomenolog account non ordinari logic base clinic observ non ordinari logic distinguish three variabl immedi effect dysfunct attempt solut das b long term effect das c salient mental phenomenon associ das maintain psycholog problem advanc could foster clinician abil identifi non ordinari logic abil devis appropri strategi solv psycholog problem | D007802;D008128 | T078;T171 |
36,256,973 | search mean medicin confront life threaten ill includ bio psycho social model health care paper aim discov discuss place spiritu mean make process patient life threaten diseas like cancer search mean serv specif role pure subject find construct cope strategi improv qualiti life mean make might essenti cope strategi research confirm spiritu integr part mean make mani patient understand find studi relev oncolog healthcar general definit religion religios spiritu present main theoret framework shown theori psycholog mean search mean discuss conceptu psychoanalyt term alongsid develop support super ego aim clarifi psycholog effect implic faith religion religios spiritu individu interperson social level influenc ill life impact life ill consid culturalsociet challeng influenc chang process intern support super ego adequ self regul subject ill percept truth influenc social behavior un conscious therefor system theoret view abil accept boundari accompani support super ego process search mean bio psycho social model integr aspect human life involv deal diseas interest bio psycho social model neither outdat new model often supplement factor spiritu part human experi throughout human histori | D011788;D029181 | T078 |
36,256,972 | neuroplast depress narrat review evid base insight major depress disord mdd one lead caus disabl worldwid current pharmacolog treatment option mdd reli mono amin hypothesi limit respect treatment non respons partial respons etc propel search novel neurobiolog understand mdd lead novel treatment option literatur search strategi thus employ use relev keyword pertain topic pubm embas googl scholar systemat review meta analys narrat review clinic trial review incorpor robust evid base literatur avail total public narrow base upon topic alter brain neuroplast evidenc chang neurotroph factor neuroimag found strong patho mechan mdd link exploit stimul psychopharmacolog research treat mdd | D003865 | T048 |
36,256,965 | postop util opioid midurethr sling surgeri prospect clinic practic studi studi perform understand opioid consumpt midurethr sling mus procedur provid surgeon guidelin appropri prescript regimen | D053825;D009293 | T074;T048 |
36,256,964 | incid risk factor genitourinari tract injuri within year surgeri pelvic organ prolaps rate genitourinari tract injuri guti follow pelvic organ prolaps pop surgeri present ill defin base relat small trial short follow time given potenti higher risk injuri pop better understand type injuri import patient counsel | D056887;D014548 | T047;T020 |
36,256,963 | current state surgic ergonom work relat musculoskelet disord widespread among surgeon caus signific disabl career modif gender play role femal surgeon two fold greater risk discomfort certain oper due general smaller hand size height compar male surgeon lack appropri surgic instrument gear toward smaller hand size maintain neutral posit oper frequent chang posit increas awar contribut decreas detriment impact surgeon bodi perform oper | D009784;D009140;D066231 | T047;T097 |
36,256,960 | caco crystal uniqu morpholog control hydrogen bond supramolecular assembl ureido pyrimidinon amino acid deriv biominer materi nacr shell exhibit high mechan strength tough account uniqu brick mortar multilay structur ureido h pyrimidinon upi deriv differ type end group due self complementari quadrupl hydrogen bond abund ca bind site easili self assembl supramolecular aggreg act templat skeleton process induc miner crystal work upi deriv use templat induc miner growth caco co diffus method morpholog caco crystal modul analyz adjust synthes paramet includ ca concentr ph end group result show regulatori role miner templat easier realiz multilay crystal structur lower concentr ca less mol l alkalin regul quadrupl hydrogen bond would destroy templat regul effect morpholog caco crystal would weaken moreov compar differ type end group proven upi deriv carboxyl acid group cooh play crucial role process caco crystal uniqu morpholog | D011744;D000596 | T123;T121;T116;T109 |
36,256,959 | clinic consensus statement vagin energi base devic clinic consensus statement vagin energi base devic ebd reflect updat content expert american urogynecolog societi ebd write group american urogynecolog societi ebd write group use modifi delphi process assess statement evalu consensus structur literatur search total statement assess divid categori patient criteria health care provid criteria efficaci safeti treatment consider statement assess reach consensus remain lack evid among main reason vulvovagin ebd treatment statement reach consensus march statement reassess use interim literatur | D003697 | T062 |
36,256,924 | effect use prediagnosi hormon breast cancer prognosi mcc spain studi extend knowledg long term use hormon hormon therapi oral contracept prognost factor breast cancer | D001943 | T191 |
36,256,917 | well age model relat inact ill injuri wami tool encourag prevent practic steep challeng fulli implement wide rang evid support rehabilit intervent prevent chronic diseas proactiv physic activ pa promot lead increas pa level improv maintain physic function higher level pa throughout lifespan lead better overal popul health well age diseas prevent chronic condit manag articl introduc well age model relat inact ill injuri wami simpl visual tool educ patient import pa exercis primari secondari tertiari prevent clinic construct wami appli bodi system affect age inact ill andor injuri exemplifi concept exercis medicin wami framework intend easi integr clinic practic clinician friend resourc base health promot provid serv catalyst enhanc patient interview educ import pa exercis video abstract avail insight author see supplement digit content avail http linkslwwcomjgpta | D057185;D015444 | T033;T056;T079;T061 |
36,256,908 | lack evid particip tmemc sensori mechanotransduct membran protein tmemc propos form mechanosensit ion channel requir normal proprioceptor function examin whether express tmemc neuroblastoma cell lack piezo associ appear mechanosensit current use three differ mode mechan stimuli indent membran stretch substrat deflect could evok mechanosensit current cell express tmemc next ask tmemc necessari normal mechanosensit cutan sensori neuron use avail mous model tmemc locus disrupt insert lacz cassett splice acceptor lead transcript truncat analysi mice indic ablat tmemc gene complet sensori neuron dorsal root ganglia drg use crisprca strategi made second mous model larg part tmemc gene delet establish tmemc mice complet lack tmemc protein drgs use ex vivo skin nerv prepar character mechanosenst mechanoreceptor nociceptor glabrous skin tmemc mice found quantit alter physiolog properti type cutan sensori fiber tmemc mice sinc claim tmemc requir normal proprioceptor function made quantit analysi locomot tmemc mice found indic alter gait tmemc mice compar wild type control summari conclud exist mous model use investig tmemc function vivo problemat furthermor could find evid tmemc form mechanosensit channel necessari normal mechanosensit cutan sensori neuron | D040542;D005727 | T023;T044 |
36,256,907 | intra household decis make effect women dietari divers evid ethiopia paper attempt analyz status women household decis make process effect dietari divers ethiopia result indic men women equal decis make author within household come particular decis food crop product proport produc crop consum home sold market incom generat activ result show variat minimum dietari divers women across region ethiopia therefor emphasi need empow women improv benefit agricultur product incom generat activ ethiopia | D005523;D005191 | T098;T099;T062;T079;T102;T081 |
36,256,888 | patient safeti incid second victim phenomenon among nurs student map factor involv incid harm patient safeti contribut second victim phenomenon among nurs student | D061214;D013338 | T058;T097 |
36,256,884 | design synthesi phenyl sulfid base cation amphiphil membran target antimicrobi agent gram posit pathogen due emerg antimicrobi resist lack new antibacteri agent becom urgent discov develop new antibacteri agent multidrug resist pathogen antimicrobi peptid amp serv first line defens host work design synthes biolog evalu seri phenyl sulfid deriv biomimick structur featur biolog function amp among deriv promis compound exhibit potent antibacteri activ gram posit bacteria minimum inhibitori concentr gml low hemolyt activ hc gml high membran select addit rapid kill gram posit bacteria within h membran target action avoid antibiot resist import show high vivo efficaci staphylococcus aureus murin corneal infect model therefor great potenti lead compound treatment gram posit bacteri infect | D006094;D000890 | T121;T007 |
36,256,882 | niphotoredox catalyz c sp c sp coupl aziridin acet alcohol deriv alkyl radic precursor aziridin readili avail c sp precursor afford valuabl function amin upon ring open articl report niphotoredox methodolog c sp c sp cross coupl aziridin methyl aliphat alcohol activ benzaldehyd dialkyl acet orthogon activ mode alkyl coupl partner facilit cross select c sp c sp bond form reaction benzaldehyd dialkyl acet activ via hydrogen atom abstract scission via bromin radic generat situ singl electron oxid bromid wherea aziridin activ ni center via reduct demonstr ni ii azametallacycl convent propos aziridin cross coupl intermedi product cross coupl rather stoichiometr organometal linear free energi relationship studi indic aziridin activ proceed via ni oxid addit previous unexplor elementari step | D000080;D001388 | T109 |
36,256,879 | identifi strategi experiment probe multidimension dynam ribosom ribosom complex biomolecular machin util larg scale conform rearrang synthes protein exampl elong cycl head domain ribosom small subunit ssu known undergo transient rotat event allow movement trna molecul ie transloc head may exhibit rigid bodi like properti precis relationship experiment access probe multidimension rotat yet establish address gap perform molecular dynam simul transloc step elong cycl ribosom ssu head spontan undergo rotat tilt like motion data set simul event use statist inform theori base measur identifi possibl singl molecul probe isol ssu head rotat head tilt analysi provid molecular interpret previous singl molecul measur establish framework design next generat experi may precis probe mechanist kinet aspect ribosom | D012270;D012343 | T026;T123;T114 |
36,256,878 | mix sandwich titanium iii qubit au electron deloc rule molecular pack organometal sandwich complex versatil molecular system recent employ singl molecul manipul spin sens experi among relat organometal compound mix sandwich complex cyclooctatetraen cyclopentadienyl titanium cpti cot attract interest spin qubit long coher time structur chemic properti cpti cot au investig monolay level experiment comput method scan tunnel microscopi suggest adsorpt occur two molecular orient lie stand ratio xps data evid fraction molecul undergo partial electron transfer gold comput analysi suggest stand molecul experi charg deloc toward surfac phenomenon depend intermolecular interact stabil molecular pack monolay orient depend molecul surfac hybrid open excit perspect select control molecul substrat spin deloc hybrid interfac | D014025;D004583 | T081;T196 |
36,256,876 | altern isotact polyhydroxyalkano via site stereoselect polymer unsymmetr diolid natur produc biodegrad polyhydroxyalkano phas promis sustain altern nonrenewabledegrad plastic biolog pha stereomicrostructur strict confin isotact r polym copolym random sequenc chemic synthesi via catalyz ring open polymer rop cyclic di ester offer expedi access divers pha microstructur includ defin comonom sequenc tactic howev synthesi altern isotact phas achiev exist methodolog report design unsymmetr disubstitut eight member diolid rac dl r r site stereoselect rop discret chiral catalyst enabl synthesi altern isotact phas poli hydroxybutyr alt hydroxyvaler alt phbv poli hydroxybutyr alt hydroxyheptano alt phbhp high quantit altern isotact n kda physic properti phas substanti determin degre backbon sequenc altern tactic rang amorph semi crystallin materi alt phbv show signific improv mechan perform relat constitu homopolym intrigu enantiomer r alt phbv alt phbv synthes kinet resolv rop rac dl et form stereocomplex signific enhanc c enantiomer homopolym form stereocomplex | D054813 | T109 |
36,256,875 | discoveri n l fucosyl amid high affin ligand pseudomona aeruginosa lectin lecb gram negat pathogen pseudomona aeruginosa caus sever infect main immunocompromis cystic fibrosi patient abl resist antimicrobi treatment extracellular lectin lecb play key role bacteri adhes host biofilm format inhibit lecb design synthes set fucosyl amid sulfonamid thiourea deriv analyz bind lecb competit direct bind assay identifi fucosyl amid unpreced high affin ligand two digit nanomolar rang x ray crystallographi one one anom n fucosyl amid complex lecb reveal interact respons high affin anom atom level molecul show good stabil murin human blood plasma hepat metabol provid basi futur develop antibacteri drug | D011550;D037102 | T123;T007;T116 |
36,256,872 | laparoscop versus abdomin radic hysterectomi cervic cancer meta analysi random control trial laparoscop radic hysterectomi lrh open abdomin radic hysterectomi arh use cervic cancer treatment aim perform meta analysi compar efficaci safeti lrh arh treatment cervic cancer provid reliabl evid clinic cervic cancer treatment | D002583;D010535 | T060;T191;T061 |
36,256,869 | tetraplex immunophenotyp cell surfac proteom via synthes plasmon nanotag portabl raman spectroscopi multiplex immunophenotyp cell surfac proteom use cell character well provid valuabl inform patient physiolog patholog state current method multiplex immunophenotyp cell surfac proteom still associ technic pitfal term limit multiplex capabl challeng result interpret larg equip footprint limit use laboratori set herein present portabl surfac enhanc raman spectroscopi ser assay multiplex cell surfac immunophenotyp synthes function customiz ser nanotag cell label subsequ signal measur use portabl raman spectromet extens evalu valid analyt assay perform portabl ser immunophenotyp assay two differ cellular model red blood cell breast cancer cell term analyt specif cell surfac immunophenotyp red blood cell breast cancer cell correl well flow cytometri portabl ser immunophenotyp assay also compar analyt repeat flow cytometri coeffici variat valu detect red blood cell breast cancer cell respect analyt detect limit cellsml red blood cell cellsml breast cancer cell altern flow cytometri portabl ser immunophenotyp assay demonstr excel analyt assay perform possess advantag quick sampl result turnaround time multiplex capabl small equip footprint | D001943;D053768 | T191;T073 |
36,256,867 | factor associ lymph node yield effect lymph node densiti surviv patient pulmonari sarcomatoid carcinoma object studi identifi factor associ lymph node yield lni surgeri pulmonari sarcomatoid carcinoma psc determin effect lymph node densiti lnd overal surviv os patient psc | D008197;D002277 | T061;T191 |
36,256,865 | janus face fluoresc imag agent malondialdehyd formaldehyd brain carbonyl stress caus reactiv carbonyl speci rcs close relat various brain diseas high reactiv high toxic lipophil rcs malondialdehyd mda formaldehyd fa could easili cross blood brain barrier bbb induc protein dysfunct cross link brain mda fa coordin regul physio patholog process brain answer question first power identif sens tool need howev compet probe simultan analyz mda fa live brain lack origin follow three challeng mda fa difficult distinguish due great similar structur reactiv achiev simultan discrimin imag excit differ emiss prefer detect mda fa live brain requir materi pass bbb thus creat two photon fluoresc agent tfch mdafa hydrazin group tfch could success differenti mdafa nm excit moreov lipophil trifluoromethyl group cf tfch prompt travers bbb therebi realiz coinstantan visual mda fa live brain use tfch observ excess product mda fa live pc cell carbonyl stress oxid stress notabl first time two photon fluoresc imag indic synchron increas mda fa live brain mice depress altogeth work provid promis tool reveal carbonyl stress relat molecular mechan involv brain diseas | D005557;D001927 | T121;T047;T131;T109 |
36,256,861 | comparison clinic genotyp characterist uropathogen escherichia coli strain accord sex korea studi compar microbiolog genotyp antibiot resist characterist uropathogen escherichia coli upec strain patient pyelonephr korea accord sex base data correspond februari june period base escherichia coli phylogenet group analysi gene virul detect subgroup analys sex observ antibiot resist percentag proport correspond extend spectrum beta lactamas produc upec higher male femal addit phylogenet group b show predomin male femal group show similar adhes molecul distribut toxin associ factor hlya cnf common male clinic present urinari predispos factor complic urinari tract infect uti concomit bacteremia persist fever also common male although femal male show upec genotyp differ differ respect poor outcom persist fever associ communiti acquir infect bacterem uti relaps uti within month associ urinari tract stone futur necessari conduct multicent studi involv case upec valid result | D056689;D004927;D014552 | T047;T007 |
36,256,860 | polymyxin b activ rescu camphen base thiosemicarbazid carbapenem resist enterobacteral due signific shortag therapeut option carbapenem resist enterobacteral cre infect new drug therapeut combin urgent requir show studi camphen base thiosemicarbazid tsc may act synergist polymyxin b pmb cre rescu activ antimicrobi specif aim better molecular understand effect caus presenc tsc theoret calcul also perform studi base find conclud presenc tsc moieti contribut signific chang hydrogen atom charg pmb structur trend posit pmbtsc system studi could lead format stronger hydrogen bond enterobacteral activ site thus contribut molecular understand pmb rescu activ promot presenc tsc moieti clinic potenti drug combin requir evalu | D011112;D015780 | T195;T116;T109 |
36,256,859 | four decad experi carcinoid heart diseas analysi patient carcinoid heart diseas chd serious cardiac condit caus elev serotonin system circul secret neuroendocrin tumour net most affect right side heart valv caus fibrot disturb associ wors surviv studi describ larg cohort patient chd provid insight surviv past decad consecut patient serotonin produc net chd refer netherland cancer institut present chd develop chd follow time includ patient divid three time period median n termin pro b type natriuret protein nt probnp serum serotonin level stratifi accord tricuspid regurgit sever kaplan meier curv log rank test use visualis surviv cox regress use identif characterist associ diseas specif mortal dsm total patient chd includ male median age net diagnosi rang year median time develop chd rang year nt probnp signific higher sever tricuspid regurgit tr present p median surviv chd diagnosi confid interv ci ci ci year p valv replac surgeri vsr occur frequent later time period vsr hazard ratio hr p nt probnp hr p signific associ dsm prognosi patient chd improv past decad possibl caus vsr nt probnp valuabl biomark patient chd clinic practic aim time diagnosi intervent chd | D002275;D014262 | T047 |
36,256,838 | function assess militari aircrew applic hypobar chamber aircrew expos environment pressur chang republ singapor air forc rsaf applic assess intermedi risk otic barotrauma undergo hypobar chamber assess trial chamber toc function evalu suitabl militari aircrew vocat | D000337;D008889;D001469 | T037;T091;T097 |
36,256,831 | ehealth care coordin older adult live home scope review popul older adult project increas potenti result older adult live chronic ill multimorbid live chronic ill increas need coordin health care servic older adult want manag ill mani posit use ehealth care coordin cc cc help older adult navig health care system improv inform share | D017216 | T058 |
36,256,827 | develop choos health digit weight loss mainten intervent intervent map studi digit health promot program tailor individu potenti cost effect scalabl solut enabl self manag provid support peopl excess bodi weight howev solut wide access person theori evid base still limit | D050177;D015431 | T033 |
36,256,825 | lysosom posit regul rab phosphoryl lrrk lysosom genet variat leucin rich repeat kinas lrrk locus contribut enhanc risk famili sporad parkinson diseas previous data demonstr recruit various membran endolysosom system result lrrk activ howev mechan under lrrk activ endolysosom membran cellular consequ event still poor understood direct lrrk lysosom earli endosom trigger lrrk autophosphoryl phosphoryl direct lrrk substrat rab rab howev direct lysosom membran prab restrict perinuclear lysosom wherea prab visual peripher perinuclear lrrk lysosom suggest lysosom posit provid addit regul lrrk depend rab phosphoryl anterograd transport lysosom cell peripheri increas express arlb skip knockdown jip block recruit phosphoryl rab lrrk absenc prab lysosom membran prevent format lysosom tubul sort process previous name lytl convers overexpress rilp result lysosom cluster within perinuclear area increas lrrk depend rab recruit phosphoryl regul rab phosphoryl perinuclear area depend counteract phosphatas knockdown phosphatas ppmh signific increas prab signal lysosom tubul perinuclear region find suggest lrrk activ multipl cellular membran includ lysosom lysosom posit provid regul rab substrat like via differenti phosphatas activ effector protein presenc nearbi cellular compart | D020691;D008247 | T026;T126;T116 |
36,256,824 | flash x ray spare intestin crypt pyroptosi initi cgas sting activ upon radioimmunotherapi dna damag treatment radiotherapi rt becom promis improv efficaci immun checkpoint inhibitor enhanc tumor immunogen howev accompani treatment relat detriment event normal tissu pose major obstacl radioimmunotherapi present new challeng dose deliveri mode clinic rt present studi ultrahigh dose rate flash x ray irradi appli counteract intestin toxic radioimmunotherapi context program cell death ligand pd l blockad flash x ray minim mous enter allevi cd cell mediat deleteri immun respons compar convent dose rate conv irradi mechanist flash irradi less effici conv x ray elicit cytoplasm doubl strand dna dsdna activ cyclic gmp amp synthas cgas intestin crypt result suppress cascad feedback consist cd cell chemotaxi gasdermin e mediat intestin pyroptosi case pd l block meanwhil flash x ray compet conv rt boost antitumor immun respons initi cgas activ achiev equal tumor control metastasi burden combin anti pd l administr togeth present studi reveal encourag protect effect flash x ray upon normal tissu without compromis system antitumor respons combin immunolog checkpoint inhibitor provid rational test combin clinic applic radioimmunotherapi | D016499;D009369 | T061;T191 |
36,256,822 | photoacoust imag guid biomimet nanoparticl target rheumatoid arthriti high level reactiv oxygen speci ros rheumatoid arthriti ra microenviron ram persist inflammatori natur promot damag joint bone synovium target strategi integr effect ram regul imag base monitor could lead improv diagnosi treatment ra report combin use small interf rnas sirna ti prussian blue nanoparticl pbnps silenc express proinflammatori cytokin tnf il scaveng ros associ ram enhanc vitro vivo biolog stabil biocompat target capabl sirna ti pbnps macrophag membran vesicl use prepar biomimet nanoparticl p sirna ti result construct found suppress tumor necrosi factor interleukin express overcom hypox natur ram thus allevi ra induc joint damag mous model p sirna ti studi could monitor via near infrar photoacoust pa imag moreov multispectr pa imag without need label permit real time evalu p sirna ti putat ra treatment clinic microcomput tomographi histolog analysi confirm effect treatment thus suggest macrophag biomimet p sirna ti analog assist pa imag could provid new strategi ra diagnosi treatment monitor | D001172;D053758 | T047;T073 |
36,256,821 | tgm mediat histon transglutamin dictat steric access recent studi identifi serotonyl glutamin histon h hqser novel posttransl modif ptm associ activ transcript hqser known instal tissu transglutaminas tgm substrat characterist affect deposit mark level chromatin individu nucleosom remain poor understood show histon serotonyl exclud constitut heterochromat region mammalian cell biochem studi reveal format higher order chromatin structur associ heterochromatin impos steric barrier refractori tgm mediat histon monoaminyl seri structur activ relationship studi includ use dna barcod nucleosom librari show steric hindranc also steer tgm activ nucleosom level restrict monoaminyl access site within histon tail collect data indic activ tgm chromatin dictat substrat access rather primari sequenc determin exist preexist ptms case mani histon modifi enzym | D006657;D009707 | T123;T116 |
36,256,820 | treatment antigen specif dual microparticl system revers advanc multipl sclerosi mice antigen specif therapi hold promis treat autoimmun diseas multipl sclerosi avoid deleteri side effect system immun suppress due deliv diseas specif antigen part treatment studi antigen specif dual size microparticl dmp treatment revers hind limb paralysi administ mice advanc experiment autoimmun encephalomyel eae treatment reduc central nervous system cns immun cell infiltr demyelin inflammatori cytokin level mechanist insight use singl cell rna sequenc show treatment impact mhc ii antigen present pathway dendrit cell macrophag b cell microglia drain lymph node also strike spinal cord cd cathepsin among common gene regul antigen present cell apc cluster b cell also numer mhc ii gene reduc efficaci treatment diminish b cell absent suggest impact therapi concert immun popul activ inflamm reduc apc cell promis antigen specif therapeut approach advantag engag essenti compon innat adapt autoimmun respons capabl revers paralysi advanc eae without use broad immunosuppress | D009103;D004681 | T047;T050 |
36,256,819 | loss rai enhanc hippocamp excit epileptogenesi mous model smith mageni syndrom hyperexcit brain circuit common featur autism spectrum disord asd genet delet chromatin bind protein retino acid induc rai caus smith mageni syndrom sms sms syndrom asd associ intellectu disabl autist featur maladapt behavior overt seizur abnorm electroencephalogram eeg pattern molecular neural mechan under abnorm brain activ sms remain unclear show panneur rai delet mice result increas seizur suscept prolong hippocamp seizur durat vivo increas dentat gyrus popul spike ex vivo brain wide map neuron activ pinpoint select cell type within limbic system includ hippocamp dentat gyrus granul cell dgcs hyperactiv chemoconvuls administr sensori experi rai defici brain delet rai glutamaterg neuron gamma aminobutyr aciderg gabaerg neuron respons increas seizur suscept delet rai emxcr lineag glutamaterg neuron result abnorm dgc properti includ increas excitatori synapt transmiss increas intrins excit work uncov mechan neuron hyperexcit sms identifi rai negat regul dgc intrins synapt excit | D058496 | T049;T047 |
36,256,818 | bacteri catabol acetovanillon lignin deriv compound bacteri catabol pathway consider potenti industri biocatalyst valor lignin major compon plant deriv biomass describ pathway respons catabol acetovanillon major compon sever industri lignin stream rhodococcus rhodochr gd previous isol growth acetovanillon high qualiti genom sequenc gd generat transcriptom analys reveal cluster eight gene regul growth acetovanillon hydroxyacetophenon well two gene cluster regul growth acetophenon bioinformat analys predict hydroxyphenylethanon hpe pathway proceed via phosphoryl carboxyl elimin yield vanil acetovanillon hydroxybenzo hydroxyacetophenon consist predict kinas hpehi phosphoryl acetovanillon hydroxyacetophenon furthermor hpecba biotin depend enzym catalyz atp depend carboxyl phospho acetovanillon acetovanillon carboxylas specif phospho acetophenon k cat k mm approxim order magnitud higher phospho acetovanillon hped catalyz effici dephosphoryl carboxyl product gd grew prepar pine lignin produc oxid catalyt fraction deplet acetovanillon vanillin vanil genom metagenom search indic hpe pathway occur relat small number bacteria studi facilit design bacteri strain biocatalyt applic identifi pathway degrad acetovanillon | D008031;D001710 | T123;T121;T127;T109 |
36,256,817 | tempor scale human scalp record potenti much human behavior govern common process unfold vari timescal standard event relat potenti analysi assum fix durat respons relat experiment event howev recent singl unit record anim reveal neural activ scale span differ durat behavior demand flexibl time employ general linear model approach use combin fix durat variabl durat regressor unmix fix time scale time compon human magneto electroencephalographi meeg data use reveal consist tempor scale human scalp record potenti across four independ electroencephalogram eeg dataset includ interv percept product predict valu base decis make trial variat tempor scale respons predict trial variat subject reaction time demonstr relev tempor scale signal tempor variat behavior result provid general approach studi flexibl time behavior human brain | D012535;D004569 | T060;T023;T034 |
36,256,816 | global profil arginin dimethyl regul protein phase separ steric effect base chemic enrich method protein arginin methyl play import role regul protein function differ cellular process dysregul may lead varieti human diseas recent arginin methyl found involv modul protein liquid liquid phase separ llps drive format differ membraneless organell mlos develop steric effect base chemic enrich method secem coupl liquid chromatographi tandem mass spectrometri analyz arginin dimethyl dma proteom level reveal secem mammalian cell dma site occur rgrgg motif preferenti enrich within protein identifi differ mlos especi stress granul sgs notabl global decreas protein arginin methyl sever impair dynam assembl disassembl sgs profil dynam chang dma upon sg format secem identifi dramat chang dma occur multipl site rgrgg rich region sever key sg contain protein includ gbp fus hnrnpa khdrbs moreov vitro arginin methyl mutat identifi dma site signific impair llps capabl four differ rgrgg rich region overal provid global profil dynam chang protein dma mammalian cell differ stress condit secem reveal import role dma regul protein llps sg dynam | D001120;D003594 | T026;T123;T121;T116;T109 |
36,256,815 | target breast pancreat cancer metastasi use dual cadherin antibodi success applic antibodi base therapeut either primari metastat cancer depend upon select rare cell surfac epitop distinguish cancer cell surround normal epitheli cell contrast circul tumor cell ctcs transit bloodstream surround hematopoiet cell dramat distinct cell surfac protein great expand number target epitop show antibodi c cadherin protein effect suppress blood born metastasi mous isogen xenograft model tripl negat breast pancreat cancer c antibodi remark recogn epitheli e cadherin cdh mesenchym ob cadherin cdh thus overcom consider heterogen across tumor cell despit efficaci singl cell circul antibodi suppress primari tumor format elicit detect toxic normal epitheli organ cadherin may engag within intercellular junction henc inaccess antibodi bind antibodi mediat suppress metastasi compar match immunocompet immunodefici mous model togeth studi rais possibl antibodi target ctcs within vasculatur therebi suppress blood born metastasi | D009360;D010190;D001943 | T191;T025 |
36,256,814 | structur function investig abc transport ste p pichia pastori reveal unexpect interact sterol molecul adenosin triphosph atp bind cassett abc transport multidomain transmembran protein facilit transport various substanc across cell membran use energi deriv atp hydrolysi import drug target sinc mediat decreas drug suscept pharmacolog treatment methylotroph yeast pichia pastori model organ wide use host protein express role function abc transport unexplor work investig pichia abc b transport ste p function investig reveal ste p capabl transport rhodamin vivo activ presenc verapamil triazol vitro phylogenet analysi display homolog among multidrug resist mdr transport pathogen fungi human abc b transport present high resolut singl particl electron cryomicroscopi structur abc transport p pastori apo conform complex verapamil adenylyl imidodiphosph amp pnp unknown densiti transmembran helic structur suggest presenc sterol bind site unknown function | D018528;D013261 | T123;T116;T109 |
36,256,813 | estim function divers speci trait ecolog monitor data twin crise climat chang biodivers loss defin strong need function divers monitor avail high qualiti ecolog monitor data increas quantif function divers far requir identif speci trait data harder obtain howev trait relev ecolog function speci also shape perform environ henc reflect indirect spatiotempor distribut thus may possibl reconstruct trait suffici extens monitor dataset use diffus map determinist de facto paramet free analysi method reconstruct proxi represent speci trait direct monitor data use estim function divers demonstr approach simul data real world phytoplankton monitor data baltic sea anticip wider applic approach exist data could great advanc analysi chang function biodivers | D044822;D010839 | T002;T080 |
36,256,812 | univers structur requir maxim robust perfect adapt biomolecular network adapt run theme biolog allow live system surviv thrive face unpredict environ maintain key physiolog variabl desir level tight regul one variabl maintain certain valu steadi state despit perturb singl input properti call robust perfect adapt rpa address solv fundament problem maxim rpa maxrpa wherebi design output variabl rpa achiev respect perturb virtual network paramet particular show maxrpa properti impos certain structur constraint network prove constraint fulli character simpl linear algebra stoichiometr condit differ determinist stochast descript dynam use result deriv new intern model principl imp biomolecular maxrpa network akin celebr imp control theori exemplifi result sever known biolog exampl robust adapt network construct exampl network aid linear algebra character result reveal univers requir maxrpa biolog system establish foundat studi adapt general biomolecular network import implic system synthet biolog | D008954;D007291 | T123;T121;T075;T114 |
36,256,811 | system racism alter wildlif genet divers unit state system racism last effect structur citi specif due govern mandat redlin polici produc racial segreg neighborhood persist today howev known whether vari habitat structur natur resourc avail associ racial segreg affect demograph evolut urban wildlif popul address question repurpos reanalyz public archiv nuclear genet data individu span terrestri vertebr speci sampl urban locat throughout unit state found general consist pattern reduc genet divers decreas connect neighborhood fewer white resid like environment differ across neighborhood strength relationship racial composit neighborhood genet divers differenti tend weak relat factor affect genet divers possibl part due recenc environment pressur urban wildlif popul howev consist direct effect across dispar taxa suggest system racism alter demographi urban wildlif popul way general limit popul size negat affect chanc persist result thus support idea limit capac support larg well connect wildlif popul reduc access natur build exist environment inequ shoulder predomin non white neighborhood | D000835;D063505 | T008;T054 |
36,256,810 | multipl form work memori emerg synaps astrocyt interact neuron glia network model persist activ popul neuron time vari activ across neural popul activ silent mechan carri hidden intern state neural popul propos differ mechan work memori wm whether mechan could mutual exclus occur neuron circuit remain howev elus biophys underpin wm tradit regard depend pure neuron mechan cortic network also includ astrocyt modul neural activ propos investig network model includ neuron glia show glia synaps interact lead multipl stabl state synapt transmiss depend paramet interact lead turn distinct pattern network activ serv substrat wm | D001253;D008570 | T025;T041 |
36,256,809 | morpholog instabl roughen grow bacteri coloni grow bacteri coloni get shape coloni morphogenesi well studi two dimens mani bacteria grow larg coloni three dimension environ gel tissu bodi subsurfac soil sediment describ morphodynam larg coloni bacteria grow three dimens use experi transpar granular hydrogel matric show dens coloni four differ speci bacteria generic becom morpholog unstabl roughen consum nutrient grow beyond critic size eventu adopt characterist branch broccoli like morpholog independ variat cell type environment condit behavior reflect key differ two dimension coloni coloni may access nutrient need growth third dimens coloni inevit becom nutrient limit interior drive transit unstabl growth surfac elucid onset instabl use linear stabil analysi numer simul continuum model treat coloni activ fluid whose dynam driven nutrient depend cellular growth find dimens coloni substanti exceed nutrient penetr length nutrient limit growth drive morpholog instabl recapitul essenti featur experiment observ work thus provid framework predict control organ grow coloni well form grow activ matter tumor engin live materi environ | D008954;D001419 | T007;T075 |
36,256,808 | marin viral particl reveal expans repertoir phage parasit mobil element phage satellit mobil genet element propag parasit bacteriophag replic report discoveri abund divers phage satellit packag concatemer repeat within natur occur bacteriophag particl seawat phage parasit mobil element found integr genom domin co occur bacterioplankton speci like known phage satellit mani marin phage satellit encod gene integr dna replic phage interfer capsid assembl mani also contain distinct gene suit indic uniqu virus hijack phage immun mobil mechan marin phage satellit sequenc widespread local global ocean virioplankton popul reflect ubiqu abund tempor persist marin plankton communiti worldwid gene content putat life cycl suggest may impact host cell phage immun defens later gene transfer bacteriophag induc cell mortal cellular host virus product given marin phage satellit distinguish bona fide viral particl via common use microscop techniqu predict number ocean may influenc current estim virus densiti product virus induc mortal total data suggest marin phage satellit potenti signific impact ecolog evolut bacteria virus throughout ocean predict habitat harbor bacteriophag also harbor similar phage satellit make ubiquit featur microbiom earth | D001435;D014780 | T005 |
36,256,807 | conform predict feedback covari shift biomolecular design mani applic machin learn method involv iter protocol data collect model train output model use choos data consid next exampl data driven approach design protein train regress model predict fit protein sequenc use propos new sequenc believ exhibit greater fit observ train data sinc valid design sequenc wet laboratori typic cost import quantifi uncertainti model predict challeng characterist type distribut shift train test data aris design set one train test data statist depend latter chosen base former consequ model error test data design sequenc unknown possibl complex relationship error train data introduc method construct confid set predict set account depend train test data confid set construct finit sampl guarante hold regress model even use choos test time input distribut motiv use case use real dataset demonstr method quantifi uncertainti predict fit design protein therefor use select design algorithm achiev accept tradeoff high predict fit low predict uncertainti | D000069550;D000465 | T170;T066 |
36,256,797 | structur basi mous receptor recognit sar cov omicron variant sudden emerg rapid spread sever acut respiratori syndrom coronavirus sar cov omicron variant rais question anim reservoir investig receptor recognit omicron receptor bind domain rbd focus four mutat qr qr ny yh surround two mutat hotspot mutat variabl effect rbd affin human angiotensin convert enzym ace enhanc rbd affin mous ace determin crystal structur omicron rbd complex mous ace structur show four mutat viral adapt mous ace three qr qr yh uniqu adapt mous ace wherea one ny adapt human ace mous ace data reveal omicron rbd well adapt mous ace omicron start infect human provid insight potenti evolutionari origin omicron variant | D000085962;D000086382 | T047;T126;T116;T067 |
36,256,786 | explor solvent substitu effect excit state dynam symmetri break quadrupolar triarylamin end cap benzothiazol chromophor femtosecond spectroscopi investig herein excit state dynam symmetri break process three benzothiazol deriv two photon absorb chromophor femtosecond fluoresc transient absorpt fs ta spectroscopi solvent various polar chromophor featur quasi quadrupolar architectur compris electron withdraw benzothiazol core later triphenylamin donor qbtz h acceptor strength central unit enforc attach cyano group qbtz cn electron donat strength arylamin moieti introduct peripher methoxi group qbtz cn steadi state spectroscopi reveal posit solvatochrom most pronounc qbtz cn femtosecond spectroscopi qbtz h reveal coexist franck condon fc state state popul symmetri break sb low polar solvent toluen tetrahydrofuran sb state becom favor polar acetonitril two molecul possess stronger electron accept unit thus polar excit state sb take place even low polar solvent shown fs ta spectroscopi global fit fs ta spectra togeth investig evolut associ spectra ea reveal exist initi fc state qbtz h studi solvent relax toward intermedi charg transfer ct sb state hand qbtz cn qbtz cn polar solvent fc state undergo ultrafast relax toward symmetri broken charg transfer sb ct state turn show fast recombin ground state measur confirm extent symmetri break larger system stronger acceptor core increas increas electron donat strength triarylamin moieti give rise symmetri break nonion quadrupolar molecul ethynylen tripl bond spacer also less polar solvent | D014050;D052160 | T109 |
36,256,728 | hepat time predict cardiovascular risk comer refer cardiovascular magnet reson post hoc analysi liver damag frequent observ patient cardiovascular diseas infrequ quantifi hypothes patient cardiovascular diseas undergo cardiac magnet reson liver time indic liver damag associ cardiovascular outcom | D002318;D008099 | T047;T023 |
36,256,725 | preprocedur multimod imag atrial fibril atrial fibril af common arrhythmia worldwid associ increas risk heart failur stroke death current medic practic multimod imag routin use manag af twenti one year ago acut trial assess cardiovers use transesophag echocardiographi result publish manag af chang forev incorpor transesophag echocardiographi guid cardiovers patient af first time current applic multimod imag af includ use transesophag echocardiographi comput tomographi cardiovers exclud left atrial thrombus left atrial appendag occlus devic implant transesophag echocardiographi cardiac comput tomographi cardiac magnet reson clinic use af ablat plan decis use particular imag modal af base patient characterist guidelin recommend institut prefer expertis cost first part review seri discuss preprocedur role echocardiographi comput tomographi cardiac magnet reson af regard clinic applic relev outcom data unmet need highlight futur direct rapid evolv field | D001281;D064847 | T060;T047;T046 |
36,256,708 | fusobacterium nucleatum induc prolifer migrat pancreat cancer cell host autocrin paracrin signal tumor microbiom increas implic cancer progress resist chemotherapi pancreat ductal adenocarcinoma pdac high intratumor load fusobacterium nucleatum correl shorter surviv patient investig potenti mechan under associ found f nucleatum infect induc normal pancreat epitheli cell pdac cell secret increas amount cytokin gm csf cxcl il mip cytokin increas prolifer migrat invas cell motil infect noninfect pdac cell noncancer pancreat epitheli cell suggest autocrin paracrin signal pdac cell phenomenon occur respons fusobacterium infect regardless strain absenc immun stromal cell block gm csf signal mark limit prolif gain infect thus f nucleatum infect pancrea elicit cytokin secret normal cancer cell promot phenotyp pdac cell associ tumor progress find support import explor host microb interact pancreat cancer guid futur therapeut intervent | D010190;D021441 | T191 |
36,256,707 | take mitochondria heart long chain fatti acid redirect uptak mitochondria releas adipocyt macrophag heart | D008928;D017667 | T026;T025;T043 |
36,256,706 | rerout drug respons overcom metabol adapt kras mutant cancer mutat guanosin triphosphatas kras common lung colorect pancreat cancer constitut activ mutant kras downstream signal pathway induc metabol rewir tumor cell promot resist exist therapeut review discuss metabol pathway alter respons treatment turn alter treatment efficaci well role metabol tumor microenviron tme dictat therapeut respons kras driven cancer highlight metabol target may provid clinic opportun overcom therapeut resist improv surviv patient aggress cancer | D016283;D010190 | T191;T126;T116 |
36,256,705 | influenc abcb cypa cypa gene polymorph prothrombin time residu equilibrium concentr rivaroxaban patient non valvular atrial fibril real clinic practic studi abcb cypaa gene polymorph gene promis term influenc prothrombin time variabl residu equilibrium concentr direct oral anticoagul doac patient atrial fibril develop new person approach anticoagul therapi patient aim studi evalu effect abcb rs c abcb rs c cypa rs g cypa rs c gene polymorph prothrombin time level residu equilibrium concentr rivaroxaban patient atrial fibril | D001281;D051544 | T047;T046;T126;T116 |
36,256,702 | proxim tubular dysfunct relat tenofovir peopl live hivaid pharmacogenet studi purpos case control studi verifi associ singl nucleotid polymorph snps gene encod drug transport relat tenofovir disoproxil fumar tdf proxim renal tubular dysfunct prtd associ prtd clinic characterist | D019380;D000163;D015658 | T121;T047 |
36,256,699 | left main stem percutan coronari intervent site surgic cover make differ nonsurg center nsc contribut signific capac overal percutan coronari intervent pci unit kingdom although previous studi demonstr similar pci outcom surgic center sc versus nsc unknown whether appli complex procedur left main stem lms pci compar patient characterist outcom lms pci perform across sc nsc england wale | D062645;D003324 | T061;T047 |
36,256,698 | econom minimalist transcathet aortic valv replac result tavr econom studi tavr trial transcathet aortic valv replac demonstr feasibl safeti next day hospit discharg transfemor tavr implement minimalist pathway howev econom impact approach unknown therefor evalu cost patient undergo minimalist tavr compar convent tavr | D001024;D065467 | T061;T047 |
36,256,696 | preemptiv septal radiofrequ ablat prevent left ventricular outflow tract obstruct transcathet mitral valv replac case seri left ventricular outflow tract obstruct may occur follow transcathet mitral valv replac set mitral annular calcif | D019918;D014694;D006349;D002114;D006330;D000078703;D006350 | T061;T074;T019;T047;T046 |
36,256,695 | ticagrelor prasugrel patient acut coronari syndrom high bleed risk relat efficaci safeti potent py inhibitor patient acut coronari syndrom high bleed risk hbr undergo percutan coronari intervent remain unclear aim studi treatment effect ticagrelor prasugrel percutan coronari intervent patient present acut coronari syndrom hbr | D054058;D000068799;D000077486 | T121;T047;T114;T109 |
36,256,694 | rate intracoronari imag optim contemporari percutan coronari intervent report bmc registri intracoronari imag ici percutan coronari intervent pci improv outcom yet hospit physician level variabl ici impact ici use contemporari pci remain unknown studi perform evalu hospit physician level use ici optim pci | D062645;D003324 | T061;T047 |
36,256,693 | predictor clinic success transcathet paravalvular leak closur intern prospect multicent registri transcathet closur symptomat prosthet paravalvular leak pvl feasibl present conclus evid show consist efficaci aim identifi predictor clinic success transcathet pvl closur | D019918;D006350;D006333 | T061;T047;T074;T046 |
36,256,684 | combinatori interact viral protein expand potenti function landscap tomato yellow leaf curl virus proteom virus manipul cell infect order replic spread due strict size restrict viral genom reduc genet space action limit number viral protein result cell reprogram observ infect long stand question explor hypothesi combinatori interact may expand function landscap viral proteom show protein encod plant infect dna virus geminivirus tomato yellow leaf curl virus tylcv physic associ one anoth intric network detect number protein protein interact techniqu import result indic intra viral protein protein interact modifi subcellular local protein involv use one particular pairwis interact virus encod c cp protein proof concept demonstr combin viral protein lead novel transcript effect host cell taken togeth result underscor import studi viral protein function context infect propos model viral protein might evolv extens interact element within viral proteom enlarg potenti function landscap avail pathogen | D053839;D010942;D018551 | T168;T005;T002 |
36,256,678 | alter express respons upon repeat gene repress singl yeast cell cell must continu adjust chang environ thus evolv mechan allow respond repeat stimuli faster gene induct upon repeat stimulus known reinduct memori respons repeat repress less studi far studi gene repress across repeat carbon sourc shift singl saccharomyc cerevisia cell monitor express carbon sourc respons gene galactokinas gal fit mathemat model singl cell data observ faster respons upon repeat repress popul level exploit singl cell data quantit model approach discov faster respons mediat shorten repress respons delay estim time carbon sourc shift gal protein product termin interest exclud two altern hypothes stronger dilut eg increas prolifer ii larger fraction repress cell upon repeat repress collect studi provid quantit descript repress kinet singl cell allow us pinpoint potenti mechan under faster respons upon repeat repress comput result studi serv start point experiment follow studi | D015966;D012441 | T045;T004 |
36,256,677 | minim invas biomark human popul biolog research part introduct special issu past sever decad biomark becom indispens tool human biolog allow research investig biocultur evolutionari question generat basic data health well human biologist central player biomark method develop pioneer creation field friend minim invas collect biomark approach well lead innov use biomark notabl map complex pathway social environment condit alter physiolog health effect special issu part collect focus minim invas collect biomark compris nine paper joint contribut drive scienc biomark method develop applic compil paper engag topic biolog normalci ecoimmunolog ethic work vulner underserv popul also focus attent research area present emphas human biolog bone turnov marker window onto osteoporosi osteoarthr use cancer relat biomark popul screen epidemiolog taken togeth paper help draw roadmap futur biomark work emphas need systemat transpar approach assay valid open access public simultan measur multipl biomark expand use instrument platform increas rang physiolog genom omic marker avail research increas attent ethic research respons encourag mindset recogn oblig provid benefit individu communiti help redress past abus | D023281 | T091 |
36,256,676 | rapid diagnost test elisa diagnos chronic chaga diseas systemat revis meta analysi determin diagnost valid enzym link immunosorb assay elisa rapid diagnost test rdt among individu suspect chronic chaga diseas cd | D003955;D014355 | T060;T047 |
36,256,675 | region short long period oscil suprachiasmat nucleus manner synchron mammal center circadian clock locat suprachiasmat nucleus scn hypothalamus mani studi suggest multipl region generat differ circadian period within scn exact local region elucid studi use transgen rat carri destabil luciferas report gene driven regulatori element per gene per dluc investig region variat period length horizont slice scn reveal distinct caudal medial region short period region spr rostro later region long period region lpr generat circadian rhythm period shorter longer hour respect also found core region scn mark dens vip vasoact intestin peptid mrna express neuron cover part lpr shell region scn contain spr rest lpr furthermor observ synchron achiev region generat distinct circadian period scn found longer circadian rhythm rostral region appear entrain circadian rhythm caudal region find clarifi local region circadian period mechan integr circadian rhythm form scn | D056950;D014660 | T125;T123;T116 |
36,256,674 | smart travel ban polici interc travel pattern affect covid trend lesson learn iran covid signific epidem centuri infect million peopl took live million individu march due rapid transmiss diseas lack definit treatment countri employ nonpharmaceut intervent studi aim investig effect smart travel ban polici implement non commerci vehicl interc highway iran sinc novemb goal suggest effici covid forecast tool examin associ interc travel pattern covid trend iran end week confirm case death due covid interc traffic flow report loop detector aggreg countri level box jenkin methodolog employ evalu polici effect use interrupt time seri analysi result indic autoregress integr move averag explanatori variabl arimax model outperform univari arima model predict diseas trend base mape criterion week interc traffic lag variabl enter covari model diseas case death result indic week interc traffic increas new week covid case death time lag two five week respect besid interrupt time seri analysi indic smart travel ban polici decreas interc travel around nonetheless signific direct effect covid trend studi suggest travel ban polici would effici lone unless coupl activ measur adher health protocol peopl | D000086382 | T047;T067 |
36,256,673 | airway clearanc physiotherapi health relat qualiti life cystic fibrosi airway clearanc physiotherapi recommend cystic fibrosi limit evid exist suggest much treatment enough secondari analysi prior studi investig safeti efficaci particip percept novel airway clearanc techniqu specif cough techniqu sct compar forc expir techniqu fet aim evalu whether intervent associ chang health relat qualiti life hrqol | D003550 | T047 |
36,256,672 | collabor individu learn geographi immers virtual realiti effect studi mani univers taught cours move onlin form sinc outbreak global pandem coronavirus diseas covid distanc learn becom broad use result wide appli lockdown howev mani student lack person contact learn process classic web base distanc learn provid mean natur interperson interact technolog immers virtual realiti ivr may mitig problem current research aim main specif instanc collabor immers virtual environ cive applic learn field util ivr knowledg construct skill train use spatial visual show promis result object studi assess effect collabor individu use ivr learn geographi specif train hypsographi furthermor studi goal determin whether collabor learn would effect investig key element collabor individu learn expect differ motiv use cognit resourc cive applic develop masaryk univers util train particip infer conclus cartograph visual collabor individu experiment group underw research procedur consist pretest train ivr posttest questionnair statist comparison geographi pretest posttest individu learn show signific increas score p es speed p es collabor learn signific increas score p es speed p es thus ivr medium prove effect tool learn geographi howev compar collabor individu learn show signific differ learn gain p es speed gain p es perform motiv p es nevertheless collabor learn group signific higher use cognit resourc p es individu learn group result discuss relat cognit load theori futur research direct ivr learn propos | D000086382;D000076142 | T047;T066;T067 |
36,256,671 | colchicin pre treatment post treatment worsen bleed function outcom collagenas induc intracerebr hemorrhag patient intracerebr hemorrhag ich increas risk major ischem cardiovascular cerebrovascular event howev use prevent antithrombot therapi increas risk ich recurr worsen ich relat outcom colchicin anti inflammatori agent potenti mitig inflamm relat atherothrombosi reduc risk ischem vascular event investig safeti efficaci colchicin use acut ich predict daili colchicin administr would impact safeti measur would reduc brain injuri improv function outcom associ inflamm reduct test mgkg colchicin given oral daili rat either given collagenas induc striatal ich assess neurolog impair intra parenchym bleed perl posit cell brain injuri gaug therapeut impact colchicin brain injuri colchicin signific affect bleed averag l hrs lesion volum averag mm day function outcom median neurolog deficit scale score day post ich ie modest deficit day ich colchicin reduc volum perl posit cell perihematom zone indic reduct inflamm safeti measur bodi weight food consumpt water consumpt hydrat bodi temperatur activ pain affect colchicin although colchicin confer neuroprotect function benefit abl reduc perihematom inflamm ich without increas bleed thus find suggest colchicin treatment safe unlik worsen bleed unlik may reduc secondari injuri ich initi earli post ich reduc risk ischem vascular event result inform ongo covasc ich phase ii random trial nct | D002543;D003078 | T121;T046;T109 |
36,256,670 | trend follow better adapt larg downsid risk avoid loss long term trend revers challeng trend follow one trade approach explor trend follow popular among investor gain increas attent academia recent diminish profit equiti market cast doubt effect clarifi caus suggest remedi thorough examin effect market condit averag window recent profit use four major stock indic sampl experi compar trend follow rule move averag momentum machin classif base non trend follow rule addit signific advantag trend follow rule avoid downsid risk find discrep optimum averag window size trend direct phase exacerb higher posit trend direct ratio higher posit trend direct ratio lead poor perform relat buy hold return discrep creat dilemma choos trend direct phase emphas incorpor machin learn trend follow effect allevi dilemma find profit maxim averag window realiz level best balanc dilemma suggest simpl guidelin select optimum averag window attribut sluggish trend follow recent equiti market insuffici chanc trend revers rather loss profit result contribut improv perform trend follow mitig dilemma | D007449;D001523 | T073;T048 |
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