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36,337,267
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research dual adgan model anomali detect method time seri data recent year anomali detect techniqu time seri data wide use manufactur cybersecur field meanwhil various anomali detect model base generat adversari network gan gradual use time seri anomali detect task howev problem unstabl generat train miss detect anomal data inconsist discrimin discrimin anomali detect target gan network aim problem paper propos dual adgan dual anomali detect generat adversari network model detect anomal data time seri first wasserstein distanc satisfi lipschitz constraint use loss function data reconstruct modul improv stabil tradit gan network train second ad data predict modul dual adgan model distinct abnorm normal sampl increas rate miss abnorm data model reduc third introduc fenc gan loss function discrimin align anomali detect target effect reduc anomali data fals detect rate dual adgan model final anomali score deriv dual adgan model compar dynam threshold detect anomali experiment result show averag f dual adgan model better nine baselin model conclus demonstr dual adgan model propos paper stabl train effect solv problem anomali miss detect discrimin inconsist anomali detect target anomali detect task
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D007091
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T066
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36,337,024
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testosteron alzheim diseas alzheim diseas ad neurodegen diseas caus dementia half case asthma usual found peopl year age etiopathogenesi diseas multifactori includ genet factor nutrit disord mitochondri dysfunct oxid stress age sex hormon import influenc develop ad evidenc higher incid women men consid signific influenc mainten normal brain function present studi aim evalu impact androgen depriv therapi adt well testosteron therapi risk ad develop progress although clinic inconsist studi androgen signific effect brain function benefici ad patient low level circul androgen consid signific risk factor develop ad memori loss reduc level plasma men administr improv cognit perform memori treatment start earli stage diseas men women ad androgen improv mental state slow progress diseas provid protect effect futur necessari conduct studi larg popul take account person factor specif approach assess cognit function causal relationship administr ad
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D000544;D019636;D011471
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T047;T191;T048
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36,337,023
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congenit hyperinsulin part kabuki syndrom kabuki syndrom rare hereditari diseas character distinct facial featur skelet abnorm mental retard development delay anomali multipl organ system developmentcongenit hyperinsulin rare manifest kabuki syndrom howev earli diagnosi crucial prevent neurolog complic hypoglycemiather type kabuki syndrom depend sever symptom kabuki syndrom type associ heterozyg mutat gene kmtd kabuki syndrom type inherit x link manner associ heterozyg mutat gene kdma character sever cours diseasethi paper present case children congenit hyperinsulin featur kabuki syndrom type type
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D015837;D006402;D000015;D044903
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T019;T047
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36,337,022
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famili form nephrogen x link diabet indiabet global trend toward increas preval diabet insipidus symptom nephrogen diabet insipidus x link inherit appear men women heterozyg mutat character isol symptom complex polyuria polydipsia hypostenuria children often adult fluid restrict clinic water defici dehydr develop hypernatremia hyperthermia plasma hyperosmol manuscript present case nephrogen diabet insipidus x link famili form male patientsat time famili along femal line mother grandmoth also increas need water use minirin ineffect older brother younger brother clinic manifest diabet insipidus form sever thirst polyuria note infanc examin diagnosi made diabet insipidus desmopressin prescribeddu lack effect use desmopressin analysi exon adjac section intron aqp avpr gene carri pcr subsequ direct sequenc mutat found aqp gene hemizyg substitut si found avpr gene famili form x confirm link nephrogen diabet insipidus hypothiazid recommend background constant intak slight posit trend observ
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D018500;D003920
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T047
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36,337,021
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donohu syndrom use continu subcutan igf pump therapi donohu syndrom ds also call leprechaun sever form insulin resist associ biallel mutat insr gene omim approxim incid syndrom per birth patient present typic clinic featur intrauterin growth retard facial dysmorph sever metabol disturb hepatomegali hypertroph cardiomyopathi ds patient die within first two year life due respiratori infect sever hypoglycemia progress cardiomyopathi treatment option limit specif therapi exist ds given similar insulin insulin like growth factor igf receptor recombin human igf rhigf use treat sever insulin resist includ dswe report case male patient genet confirm donohu syndrom success treat continu subcutan igf infus via insulin pump observ improv glycem control liver function cardiac hypertrophi regress follow month igf therapi
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D056731;D007333
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T047;T046
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36,337,020
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diabet gastroenteropathi modern method diagnosi treatment diabet mellitus chronic diseas grow preval worldwid howev preval complic includ gastroenteropathi also increas pathophysiolog diabet gastroenteropathi dh combin hyperglycemia vagus nerv dysfunct decreas express nitric oxid synthas myenter plexus chang interstiti cajal cell network well oxid stress clinic sign dh gastroesophag reflux gastroparesi constip abdomin pain diarrhea among diagnost method manometri ph measur assess esophag motil gastric empti scintigraphi respiratori test assess gastroparesi aspir cultiv content jejunum diagnos bacteri overgrowth syndrom date definit treatment dh interdisciplinari approach aim slow progress diseas reliev symptom restor gastrointestin function patient recommend diet low simpl sugar high fiber optim glycem control target glycemia less mgdl drug therapi use prokinet antiemet justifi case excess bacteri growth syndrom antibacteri therapi rifaximin carri modern approach treatment dh also accumul includ use botulinum toxin pyloroplasti electr stimul stomach individu patient despit constant develop new treatment yet abl complet cure dh near futur make necessari conduct research area
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D018589;D005767;D003929;D003920
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T047
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36,337,019
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fgf tumor induc osteomalacia tumor induc osteomalacia rare acquir diseas caus mesenchym tumor secret fibroblast growth factor fgf excess amount fgf disrupt metabol phosphorus vitamin lead sever paraneoplast syndrom manifest form multipl fractur sever pain bone general myopathi oncogen osteomalacia complet cure possibl radic resect tumor unfortun local small size format rare frequenc occurr lead fact diseas remain unrecogn long time lead sever disabl consequ step step approach diagnosi improv treatment outcom first thorough anamnesi collect function visual perform diagnosi confirm anatom visual tumor method choic surgic treatment resect possibl conserv therapi activ metabolit vitamin phosphorus salt indic new therapeut approach antibodi fgf pan inhibitor receptor fgf activ develop articl provid overview modern approach diagnosi treatment diseas
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D010018;D009372;D010257
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T047;T191
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36,337,018
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metformin malign neoplasm possibl mechan antitumor action prospect use practic metformin first line antidiabet drug treatment type diabet mellitus dm molecular target amp activ protein kinas ampk involv mani metabol process metformin reduc blood glucos level improv insulin sensit also inhibit lipolysi reduc cardiovascular risk patient dm recent year proven metformin slow age process stimul hair growth elimin cognit impair also antitumor effect basic studi shown metformin inhibit growth tumor cell promot cellular apoptosi clinic studi show contradictori result discrep explain differ concentr metformin basic clinic studi maximum daili dose metformin patient dm mg day dose use basic research much higher metformin direct activ ampk signal pathway inhibit product reactiv oxygen speci induc activ mtorc inhibit cyclin lead reduct risk occurr develop malign neoplasm addit metformin indirect inhibit tumor growth prolifer invas metastasi reduc concentr glucos blood insulin resist well reduc inflamm affect tumor microenviron glycolysi play import role energi metabol tumor metformin abl inhibitori effect current studi mechan antitumor effect metformin becom extens depth still contradict
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D008687;D003924;D009369;D007333
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T121;T109;T191;T047;T046
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36,337,017
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diagnosi tactic manag patient central diabet insipidus exampl clinic case diagnosi differenti diagnosi patient diabet insipidus often difficult task endocrinologist case report focus patient long histori central idiopath diabet insipidus substanti decreas desmopressin requir last year follow conduct test osmot stimul test water depriv infus test hyperton solut made possibl answer question persist diseas well determin manag plan take account physiolog characterist patient
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D020790;D003919;D003920
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T047
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36,337,016
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primari hypothyroid postmenopaus caus delay diagnosi panhypopituitar patient nonfunct pituitari adenoma hypopituitar state complet partial defici pituitari hormon includ adren insuffici hypothyroid hypogonad growth hormon defici rare diabet insipidusth articl describ clinic case hypopituitar due pituitari tumor postmenopaus woman difficulti diagnos hypopituitar due histori primari hypothyroid first identifi compon panhypopituitar patient central hypothyroid previous seen laboratori indic medic induc hyperthyroidismth non specif natur clinic symptom well relat rare combin endocrin diseas led long examin period delay diagnosi pituitari tumorwheth develop hypopituitar patient nonfunct pituitari tumor indic transsphenoid pituitari surgeri remain controversi issu decis surgeri made take account characterist cours diseas particular patient clinic case conserv tactic chosen hormon replac therapi glucocorticoid thyroid defici
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D010911;D000236;D007018;D007037
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T047;T191
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36,337,015
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syndrom hypocaliur hypercalcemia rare two clinic case outpati clinic hypocalciur hypercalcemia syndrom famili hypocalciur hypercalcemia fhh inherit condit base dysfunct calcium receptor associ partner protein recent evid suggest preval condit may compar primari hyperparathyroid clinic manifest fhh usual absent howev classic symptom hypercalcemia may present case time differenti diagnosi fhh avoid unnecessari expens instrument examin well ineffect treatment clinic case present public demonstr unjustifi difficulti issu necess rais awar physician famili hypocalciur hypercalcemia
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D006934;D006961;D007674
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T047
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36,337,014
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pituitari covid review sever acut respiratori syndrom coronavirus sar cov rapid spread around world sinc first scientif describ decemb present approxim million peopl suffer diseas almost million peopl diedsar cov use angiotensin convert enzym ace serin proteas tmprss protein prime ace tmprss express sever endocrin gland includ pituitari pancrea thyroid ovari test thus endocrin gland may direct target sar cov main risk factor sever covid obes arteri hypertens diabet mellitus dm vertebr fractur potenti predispos patient sever cours covid review present current data cours covid patient hypothalam pituitari diseas also discuss treatment endocrinopathi covid
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D000086382;D010900
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T047;T067
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36,337,013
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short statur due intrauterin growth retard clinic hormon metabol featur possibl growth stimul therapi articl present data short statur due intrauterin develop delay type short statur separ nosolog unit children born small gestat age major first year life acceler growth rate allow child normal weight growth indic catch develop peer absenc acceler growth rate children high risk lag behind physic develop throughout childhood achiev low final growth becom short adult addit fact birth small bodi size associ number hormon metabol featur risk metabol syndrom adult yearsit assum absenc postnat growth acceler due various damag gh igf axi partial gh defici partial resist gh partial resist igf growth hormon therapi initi earli life abl normal growth rate childhood ultim signific improv normal final growth short statur children born small gestat age
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D019382;D004392
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T125;T121;T116;T019
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36,336,899
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tumor treat field radiat glioblastoma narrat review phase clinic trial ef clinicaltrialsgov nct current underway examin potenti benefit concurr chemoradi tumor treat field ttfield patient glioblastoma gbm present follow narrat review highlight current evid support approach current manag paradigm gbm includ maxim safe surgic resect follow concurr chemoradi temozolomid tmz ttfield use mainten therapi despit sever treatment advanc past decad overal prognosi remain poor new strategi current investig includ use chemoradi concurr ttfield
|
D005909;D001932
|
T191
|
36,336,898
|
role proxim gastrectomi gastric cancer past year preval upper third gastric cancer gc gastroesophag junction gej cancer increas total gastrectomi lymph node dissect standard surgic treatment non earli higher upper third gej cancer total gastrectomi often result post gastrectomi syndrom consist weight loss dump syndrom anemia proxim gastrectomi pg potenti avoid postop problem preserv stomach function howev pg histor discourag surgeon owe high incid postop reflux esophag anastomot stenosi decreas qualiti life recent year anti reflux reconstruct techniqu doubl flap techniqu doubl tract reconstruct develop perform pg evid emerg techniqu reduc incid postop reflux esophag also decreas postop weight loss prevent anemia prospect studi underway determin whether pg anti reflux techniqu improv patient report qualiti life present work review avail evid use pg gc gej cancer includ oncolog appropri patient select pg potenti function benefit pg tg various type reconstruct perform pg well futur research use pg
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D013274;D004942
|
T047;T191
|
36,336,897
|
radiotherapi elder patient glioblastoma assess hypofraction modern treatment techniqu glioblastoma gbm diseas poor prognosi decad radiotherapi play critic role manag gbm standard care radiat prescript gy fraction landmark trial histor exclud patient older year current consider variat manag elder patient gbm shorten radiat treatment hypofraction regimen explor sinc convent treatment schedul lengthi mani elder patient function cognit social limit clinic trial demonstr effect hypofraction radiotherapi gy fraction treat elder frail patient gbm although previous studi suggest uniqu hypofraction prescript effect treat patient mani avenu improv patient popul herein describ uniqu tumor biolog glioblastoma key hypofraction radiotherapi studi health relat qualiti life hrqol studi elder patient gbm hypofraction radiat emerg shorten altern retrospect studi suggest surviv outcom similar elder patient gbm prospect studi compar hypofraction convent treatment regiment warrant addit evalu surviv outcom hrqol endpoint incorpor futur studi
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D005909;D001932
|
T191
|
36,336,892
|
tacrolimus induct therapi nephrot syndrom caus minim mesangi lupus nephriti lupus podocytopathi case base review background nephrot syndrom caus minim mesangi lupus nephriti consid rare nephrot syndrom caus minim mesangi lupus nephriti diffus epitheli foot process effac lupus podocytopathi case report year old japanes woman diagnos mix connect tissu diseas admit weight gain general edema week prior admiss butterfli shape erythema cheek proteinuria leukocytopenia lymphocytopenia hypoalbuminemia posit antinuclear antibodi specif autoantibodi posit ribonucleoprotein rnp antigen diagnos system lupus erythematosus renal biopsi show minor glomerular abnorm immunofluoresc reveal peripher deposit igm complement cc electron microscopi reveal diffus podocyt foot process effac capillari loop surfac subendotheli deposit consequ diagnos minim mesangi lupus nephriti lupus podocytopathi hospit day administ mgday methylprednisolon day follow prednisolon mgday proteinuria persist day administ tacrolimus mgday proteinuria improv disappear day prednisolon gradual taper stop year although tacrolimus mgday continu flare observ year admiss conclus tacrolimus show good efficaci case minim mesangi lupus nephriti lupus podocytopathi prospect random control trial conduct demonstr efficaci tacrolimus indic
|
D008181;D009404;D008180
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T047
|
36,336,891
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mechan progesteron treatment traumat brain injuri base network pharmacolog molecular dock technolog background previous studi confirm progesteron protect effect traumat brain injuri tbi paper network pharmacolog molecular dock technolog use explor potenti mechan progesteron treatment tbi materi method base network pharmacolog potenti target progesteron tbi obtain network diagram interact target protein establish screen key target progesteron tbi david databas use analyz biolog function enrich pathway explor determin biolog pathway progesteron treat tbi molecular dock technolog use simul interact progesteron key target protein result progesteron treat tbi anti inflammatori action repair damag cell membran stabil structur blood brain barrier allevi brain edema reduc neuron apoptosi improv neurolog function molecular mechan involv pikakt signal pathway mapk signal pathway ras signal pathway conclus progesteron potenti clinic treatment tbi explor potenti target pathway tbi therapi network pharmacolog provid direct subsequ research
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D000070642;D004365
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T123;T121;T037
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36,336,882
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synthesi deimat behaviour deimat behaviour also refer startl behaviour use predat rival although mani spectacular proxim ultim caus remain unclear review aim synthesis known deimat behaviour identifi knowledg gap propos work hypothesi deimat behaviour discuss avail evid evolut ontogeni causat surviv valu deimat behaviour use tinbergen four question framework overarch aim direct futur research suggest way address press question field
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D011235
|
T054
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36,336,872
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vitamin prevent autoimmun diseas vitamin essenti regul immun system recent year role vitamin control sever autoimmun condit inflammatori bowel diseas ibd celiac diseas type diabet mellitus tdm other investig aim review defin level knowledg vitamin role disord well prevent therapeut role vitamin supplement relev studi publish last year identifi via pubmedmedlin http wwwncbinlmnihgovpubm search use keyword vitamin autoimmun diseas prevent vitamin defici impair function enzym necessari activ shown affect onset sever autoimmun diseas examin vitamin supplement appear use support therapi ibd role celiac diseas autoimmun hepat tdm autoimmun thyroid unclear conclus studi need defin whether vitamin caus result common autoimmun extra skelet diseas ibd vitamin provid newborn first year life afterward vitamin supplement regimen tailor presenc risk factor vitamin defici andor specif diseas
|
D003922;D002446;D014808;D001327;D015212
|
T047
|
36,336,871
|
nitro oxid stress mitochondri dysfunct human cell line expos environment contamin pfoa bpa bisphenol bpa perfluorooctano acid pfoa synthet compound wide util industri activ devot product daili life plastic metal product packag abl migrat food water due persist environ live organ chronic expos pollut bpa pfoa advers effect tissu organ aim studi identifi molecular target biochem mechan involv toxic
|
D018384;D008928
|
T026;T049;T043
|
36,336,870
|
pathogenesi marker hashimoto diseas mini review hashimoto thyroid ht common autoimmun diseas involv thyroid gland ht often clinic manifest hypothyroid due destruct thyroid cell mediat humor cellular immun pathogenesi ht complex process environment factor hereditari inclin trace element immun factor cytokin dna mirna play import role herein summar precis factor involv pathogenesi ht offer updat past year provid theoret basi investig relev target ht treatment
|
D050031;D007037;D001327
|
T047
|
36,336,869
|
effect nano microplast inflammatori process vitro vivo studi systemat review microplast mps nanoplast nps plastic fragment spread environ accumul human bodi becom worldwid environment concern potenti human health effect aim systemat review investig prospect impact mps nps inflammatori process
|
D000080545
|
T122
|
36,336,868
|
combin nativ lc ms approach comprehens character antibodi drug conjug trastuzumab deruxtecan nativ mass spectrometri nms approach appear attract complement bottom strategi tradit use biopharmaceut industri thank quit straightforward rapid workflow especi onlin hyphen non denatur liquid chromatographi lc nms present work provid overview state art chromatograph tool avail detail character monoclon antibodi mab format exemplifi antibodi drug conjug adc trastuzumab deruxtecan dxd
|
D053719;D018796
|
T063;T129;T121
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36,336,867
|
perspect use toxicogenom assess environment risk environment toxicogenom aim collect analyz interpret data chang gene express protein activ result exposur toxic substanc use high perform omic technolog molecular profil method genom transcriptom proteom metabolom bioinformat techniqu permit simultan analysi multitud gene variant organ expos toxic agent search gene prone damag detect pattern mechan toxic identifi specif gene express profil provid biomark exposur risk compar previous approach measur molecular chang caus toxic toxicogenom technolog improv environment risk assess reduc anim studi discuss prospect limit convert omic dataset valuabl inform focus assess risk mix toxic substanc environ human health
|
D043922;D023281
|
T091
|
36,336,866
|
potenti low phytic acid mutant maiz zea may l sustain solut non renew phosphorus phosphorus essenti compon fertil feed recent decad becom one main sustain issu non renew resourc plant seed main reserv phosphorus phytic acid strong anti nutrit factor monogastr pollut cultiv land reduct phytic acid cereal seed becom major challeng breed program increas nutrit qualiti food feed improv environment phosphorus sustain agricultur maiz zea may l four low phytic acid lpa mutat isol lpa promis howev reduct phytic acid lpa lead mani advers pleiotrop effect seed general plant perform seed weight reduct consequ yield loss previous describ mutant
|
D003313;D010833
|
T121;T127;T109;T168;T130;T002
|
36,336,865
|
role grpperkatf pathway abil gua lou gui zhi decoct attenu apoptosi inhibit endoplasm reticulum stress ischemia reperfus injuri endoplasm reticulum stress er key part apoptot cascad initi cerebr ischemia reperfus injuri import research poststrok rehabilit addit unfold protein respons upr play import role er activ downstream apoptot signal transduct induc apoptosi glucos regul protein grp protein kinas r pkr like er kinas perk activ transcript factor atf pathway gua lou gui zhi decoct glgzd amelior neuron apoptosi ischemia reperfus injuri caus middl cerebr arteri occlus mcao prove previous studi present studi aim under regulatori abil glgzd er induc apoptosi mediat grpperkatf pathway
|
D059865;D015427
|
T049;T037
|
36,336,864
|
correl low thbs express peripher blood acut myocardi infarct thrombospondin thbs adhes glycoprotein involv cell cell cell matrix interact purpos studi determin whether thbs express peripher blood use biomark predict risk acut myocardi infarct ami
|
D009203;D003324
|
T047
|
36,336,863
|
exosom anticanc drug deliveri vehicl prospect challeng exosom subset extracellular vesicl wide present various bodi fluid involv mediat intercellular communic receiv extens attent diagnost marker excel physicochem biolog properti exosom make great potenti drug deliveri vehicl treatment cancer diseas howev various challeng need address clinic applic exosom review introduc biogenesi uptak exosom compar differ approach isol drug load focus applic current challeng exosom drug deliveri vehicl cancer therapi
|
D055354;D000970;D000067128;D009369
|
T026;T121;T191;T109
|
36,336,862
|
drug coat balloon drug beyond paclitaxel although controversi discuss paclitaxel clinic proven drug inhibit restenosi releas drug coat balloon dcbs limus drug current explor altern aim preclin studi investig drug candid beyond paclitaxel consid balloon coat
|
D017239;D015906
|
T061;T121;T109
|
36,336,861
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effect singl high dose vitamin serum level metabolit elder vitamin dietari micronutri respons calcium phosphorus metabol multipl extraskelet action assess vitamin status common base measur oh total concentr serum howev usag liquid chromatographi tandem mass spectrometri lc msms techniqu allow reliabl assess panel vitamin metabolit serum plasma may help investig metabol path vitamin especi popul risk defici
|
D053719;D014807
|
T063;T121;T127
|
36,336,860
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deubiquitin enzym usp function oncoprotein gastric cancer mediat nf b signal regul prl express report ubiquitin specif peptidas usp function sever tumor function mechan gastric cancer still unknown
|
D016328;D013274
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T129;T191;T116
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36,336,859
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natur biolog acceler heal diabet foot ulcer regul oxid stress difficult even non heal diabet foot ulcer dfu global medic challeng although current treatment debrid offload infect control result partial improv dfu incid amput mortal rate dfu remain high therefor urgent need find new effect drug numer studi shown oxid stress play import role pathophysiolog dfu nuclear factor erythroid relat factor nrf signal pathway advanc glycat end product age receptor advanc glycat endproduct rage protein kinas c pkc polyol hexosamin biochem pathway play critic role regul oxid stress bodi target pathway restor redox balanc control allevi occurr develop dfu natur biolog major sourc potenti drug relev target antioxid potenti extens demonstr discuss pathophysiolog mechan oxid stress dfu identifil natur biolog target pathway acceler dfu heal order provid new potenti direct clinic treatment nurs relat basic research dfu
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D017719;D001688;D003920
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T123;T047;T121
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36,336,858
|
express predict function profil microrna data vascular composit allotransplant acut reject studi aim investig mechan acut reject vascular composit allotransplant vca use microrna mirna differenti express vca anim model
|
D035683;D063986
|
T061;T123;T114
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36,336,857
|
human urinari kallidinogenas pretreat inhibit myocardi inflamm apoptosi coronari microembol activ pikaktfoxo axi fatal cardiovascular complic coronari microembol cme result sever cardiac dysfunct arrhythmia associ myocardi inflamm apoptosi human urinari kallidinogenas huk provid protect function cardiomyocyt improv microcircul howev therapeut effect under mechan huk cme induc myocardi injuri remain unclear
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D019869;D051057
|
T126;T116
|
36,336,856
|
character intestin microbiom healthi adult sar cov vaccin respons outbreak coronavirus diseas covid worldwid inactiv sever acut respiratori syndrom coronavirus sar cov vaccin implement dysbios gut microbiota implic covid patient wherea intestin microbiota affect vaccin remain elus import investig microbi shift vaccin treatment
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D000069196;D000086382
|
T067;T047;T007;T001
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36,336,855
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perform ltbi screen patient rheumat diseas use two differ interferon gamma releas assay evalu concord quantiferon tb gold tube test qft git spottb test spot screen latent tuberculosi infect ltbi patient rheumat diseas rds
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D055985;D012216;D001172;D008180
|
T047
|
36,336,854
|
role intestin flora anti tumor antibiot therapi anti tumor antibiot chemic substanc produc micro organ control cancer develop current use cancer treatment regimen anti tumor antibiot howev mani studi demonstr anti tumor antibiot may advers effect normal cell call develop strategi allevi negat effect improv cancer treatment recent studi suggest efficaci anti tumor antibiot may affect intestin microbiota instanc intestin microbiota allevi negat effect antibiot treatment regul tumor immun micro environ way anti tumor antibiot improv tumor control howev specif mechan need explor review discuss effect intestin flora anti tumor antibiot therapi summar specif mechan antibiot inhibit harm intestin micro organ promot efficaci probiot may improv control neoplasm develop growth
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D000069196;D019936;D009369
|
T007;T191;T001
|
36,336,853
|
imput human primari osteoblast singl cell rna seq data identifi three novel osteoblast subtyp recent singl cell rna sequenc scrna seq technolog increas use studi transcriptom singl cell resolut scrna seq analysi complic dropout data captur small fraction transcriptom phenomenon lead fact actual express transcript may detect previous perform osteoblast subtyp classif dissect fresh isol human osteoblast
|
D010006;D059467
|
T081;T025;T086
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36,336,789
|
novel multi scale cnn weight focal loss arrhythmia detect vari dimension ecg object ecg standard diagnost tool identifi mani arrhythmia accur diagnosi earli intervent arrhythmia great signific prevent treatment cardiovascular diseas object develop algorithm automat identifi arrhythmia use vari dimension ecg signal approach paper first propos novel multi scale cnn effect captur patholog inform small scale larg scale ecg signal identifi arrhythmia lead lead lead lead lead ecg second explor effect vari convolut kernel size branch subnetwork model perform arrhythmia third introduc weight focal loss allevi posit negat class imbal problem multi label arrhythmia classif fourth explor util reduc lead ecg detect arrhythmia compar perform model vari dimension ecg main result follow entri physionetcomput cardiolog challeng propos approach achiev offici test score lead lead lead lead lead ecg hidden test set compar th th th th th team challeng signific multi scale framework capabl detect arrhythmia vari dimension ecg propos work preliminarili verifi multi scale percept field may necessari captur comprehens patholog inform arrhythmia detect besid also verifi weight focal loss may allevi posit negat class imbal improv model general perform cross dataset addit observ reduc lead model lead lead model even achiev perform almost compar lead model excel perform propos framework demonstr great potenti detect wide rang arrhythmia
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D004562;D001145
|
T060;T047;T074
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36,336,787
|
singl cell rna sequenc reveal cellular molecular reprogram landscap glioma lung cancer brain metastas brain malign encompass glioma brain metastas origin extracrani tumour includ lung cancer approxim patient lung adenocarcinoma luad eventu develop brain metastas howev specif characterist glioma lung brain metastas lc larg unknown
|
D005910;D001932;D008175
|
T191
|
36,336,786
|
novel insight origin develop cns macrophag subset central nervous system cns host varieti immun cell includ two distinct macrophag popul microglia found parenchyma wherea cns associ macrophag cam cover cns interfac perivascular space mening choroid plexus recent studi given novel insight natur cam compar microglia mini review summaris current knowledg ontogenet relationship under mechan establish cns macrophag develop
|
D002490;D008264
|
T022;T025
|
36,336,785
|
comprehens profil human viral exposom household contain risk child mitochondri diseas covid pandem viral infect major caus morbid children mitochondri diseas mtd result famili children mtd high adher risk mitig behaviour rmbs advis center diseas control prevent covid pandem modul infect risk
|
D000086382;D000081413;D014777;D028361
|
T047;T058;T067
|
36,336,784
|
blockad pentraxin cd interact attenu lung injuri induc fibrosi fibros interstiti lung diseas fild potenti fatal limit therapeut option effect strategi revers fibrogenesi myofibroblast chief effector cell fibrosi excess deposit collagen pulmonari interstitium lead progress impair gaseous exchang
|
D011658;D055370
|
T047;T037
|
36,336,772
|
leptomening carcinomatosi patient recurr unresect squamous cell carcinoma retromolar trigon brief report report incid leptomening carcinomatosi patient solid tumour common describ set advanc cancer lung breast malign melanoma
|
D055756;D002294;D006258
|
T191
|
36,336,763
|
substrat induc gate mechan conserv among gram posit iga metalloproteas mucos adapt immun respons depend product iga antibodi particular iga yet opportunist bacteria evolv mechan specif block respons produc iga proteas igap lab first describ structur metal depend igap metallo igap produc gram posit streptococcus pneumonia absenc presenc iga substrat cryo em singl particl reconstruct prior studi reveal activ site gate mechan reliant substrat induc conform chang enzym beg question whether mechan conserv among wider gram posit metallo igap subfamili virul factor use cryo em character metallo igap distant relat famili member gemella haemolysan emerg opportunist pathogen implic mening endocard recent bacteremia elder substrat free structur two metallo igap exhibit differ relat start posit domain respons gate substrat enzym similar domain orient bound iga togeth biochem studi indic metallo igap similar bind affin activ data indic metallo igap bind requir specif iga substrat open enzym access activ site thus larg conform induc fit model
|
D007070;D045726
|
T129;T126;T116
|
36,336,760
|
quantif receptor bind respons data obtain differ receptor level simpl individu sigmoid fit unifi sabr approach method allow quantif receptor bind occup measur respons effect data interest use allow character bind properti eg dissoci constant k without perform explicit ligand bind experi requir differ setup eg use label ligand howev sinc respons depend bind affin determin receptor occup also receptor activ affect ligand efficaci plus constitut activ present downstream pathway amplif requir acquisit fit multipl concentr respons data two altern method straightforward implement use nonlinear regress softwar describ fit multipl respons measur differ receptor level obtain exampl partial irrevers receptor inactiv ie furchgott method differ express level one simpl method via straightforward fit respons sigmoid function estim k obtain e max ec valu k e max ec e max ec e max e max less error prone origin furchgott method doubl reciproc fit simpler altern requir concentr interpol thus allow widespread use far underutil approach estim bind properti relat efficaci compar use e max k ec valu complex method use sabr receptor model obtain unifi fit multipl concentr respons curv singl set paramet includ bind affin k efficaci amplif hill coeffici n illustr simul experiment data present includ activ data three muscarin agonist measur rabbit myocardium
|
D012984
|
T090;T170;T073
|
36,336,749
|
craniofaci three dimension palat analysi cleft lip palat patient treat spain growth alter describ patient oper oral cleft purpos work analyz craniofaci palat morpholog dimens young adult oper oral cleft earli childhood spain eighti three patient eight differ hospit divid four group base type cleft cleft lip cl n unilater cleft lip palat uclp n bilater cleft lip palat bclp n cleft palat cpo n control group form individu three dimension digit model obtain group intraor scanner togeth cephalometri frontal later subment facial photograph measur obtain analyz statist result show craniofaci alter bclp uclp cpo group influenc palat maxilla mandibl direct impact facial appear effect sever bclp group measur cl group similar control group cleft characterist cleft type seem main determin factor long term craniofaci growth alter patient prospect research need clear delin effect differ treatment craniofaci appear adult cleft patient
|
D002971;D002972
|
T019
|
36,336,726
|
predict lower incisor tip use clear align therapi upright incisor particular import clear align therapi incisor tip determin mesio distal space need arch consequ fit align object studi investig accuraci clincheck softwar predict lower incisor tip compar digit prescrib movement actual clinic outcom determin whether presenc vertic orient rectangular composit attach influenc efficaci incisor tip
|
D007180;D009968
|
T023;T074
|
36,336,717
|
sleep eeg envelop novel neuron fire base human biomark sleep eeg reflect voltag differ relat refer spectrum reflect composit various frequenc contrast envelop sleep eeg reflect instantan amplitud oscil spectrum reflect rhythmic occurr oscil sleep eeg spectrum known relat demograph psycholog clinic characterist envelop spectrum rare studi studi demonstr human invas data cortex penetr microelectrod subdur grid sleep eeg envelop spectrum reflect neuron fire studi demonstr scalp eeg envelop spectrum stabl within individu multivari learn algorithm could predict age r sex r eeg envelop spectrum age oscil shift rhythm faster rhythm result demonstr sleep envelop spectrum promis biomark demograph diseas relat phenotyp
|
D004569;D012890
|
T060;T033;T040;T034
|
36,336,709
|
self report sleep qualiti mental health mediat relationship chronic diseas suicid ideat among chines medic student high preval strong associ chronic diseas poor sleep qualiti poor mental health suicid ideat si report worldwid howev under mechan remain unexamin particip chines medic colleg student averag age year pittsburgh sleep qualiti index kessler psycholog distress scale si evalu lifetim si past month si chronic diseas preval rate respect result logist regress analysi studi found chronic diseas self report poor sleep qualiti poor mental health gender scholarship associ lifetim si similar result also found month si except region result indic effect chronic diseas si mediat self report sleep qualiti mental health physic diseas sleep relat concern mental health issu need address multidisciplinari team approach various deliveri system prevent si among medic colleg student
|
D059020;D013337
|
T033;T097
|
36,336,707
|
simul global warm affect endophyt bacteri fungal communiti antarct pearlwort leav bacteri isol support plant growth low temperatur antarctica one stress environ plant life antarct pearlwort colobanthus quitensi adapt hostil condit plant associ microorgan contribut plant surviv cold environ scarc inform avail taxonom structur function role c quitensi associ microbi communiti studi aim evalu possibl impact climat warm taxonom structur c quitensi endophyt investig contribut cultur bacteri endophyt plant growth low temperatur cultur independ analysi reveal chang taxonom structur bacteri fungal communiti accord plant growth condit collect site presenc open top chamber otc simul global warm plant grown insid otc show lower microbi rich higher relat abund biomark bacteri genera allorhizobium neorhizobium pararhizobium rhizobium aeromicrobium aureimona hymenobact novosphingobium pedobact pseudomona sphingomona fungal genera alternaria cistella vishniacozyma compar plant collect open area oa possibl respons global warm simul otc cultur psychrotoler bacteria c quitensi abl endophyt colon tomato seedl promot shoot growth low temperatur suggest potenti contribut plant toler cold condit
|
D057232;D000072761
|
T004;T069
|
36,336,706
|
function connect respons acut pain assess fnir associ bdnf genotyp fibromyalgia exploratori studi fibromyalgia heterogen primari pain syndrom whose sever associ descend pain modulatori system dpms function function connect fc pain process area brain deriv neurotroph factor bdnf valmet singl nucleotid polymorph link vulner chronic pain cross section imag genet studi investig fibromyalgia relationship bdnf valmet heterozyg genotyp valmet function connect fc respons pattern acut pain stimulus motor mc prefront pfc cortex assess near infrar spectroscopi fnir cold pressor test util water c also assess relationship genotyp dpms function qualiti life includ women valval valmet fibromyalgia age mancova compar valmet valval genotyp show higher fc left l pfc l mc p l pfc right r pfc p l pfc r mc p l mc r pfc p valmet genotyp show higher effici dpms lower disabl due pain show fibromyalgia patient carri valmet bdnf genotyp present increas fc across mc pfc respons acut pain associ differ acut pain percept fibromyalgia symptom
|
D005356;D059787
|
T184;T047
|
36,336,705
|
identifi plastic photoluminesc spectroscopi machin learn quantit understand worldwid plastic distribut requir assess extent possibl impact plastic litter environ also identifi possibl counter measur systemat collect data character amount composit plastic base two crucial compon experiment approach simpl enough access worldwid sensibl enough captur divers plastic ii analysi pipelin abl extract relev paramet vast amount experiment data studi demonstr approach could realiz combin photoluminesc spectroscopi machin learn base theoret analysi show appropri combin classifi dimension reduct algorithm abl identifi specif materi properti spectroscop data best combin base unsupervis learn techniqu make approach robust altern input data
|
D010969;D000069550
|
T066;T167
|
36,336,704
|
short exposur semi natur habitat allevi honey bee hive microbi imbal caus agricultur stress honeybe health speci gut microbiota interconnect also noteworthi multipl nich present within hive distinct microbiota coexist term apibiom extern stressor eg anthrop compromis microbi balanc bee resili hypothesis bacteri communiti hive locat area differ degre anthrop differ composit due interact multipl microbiom within apibiom chang communiti nich would impact bacteria present hive section characteris bacteri consortia differ nich bee gut bee bread hive entranc intern hive air hive differ environ agricultur semi natur natur rrna amplicon sequenc agricultur sampl present lower communiti even deplet benefici bacteria increas recruit stress relat pathway predict via picrust taxonom function composit gut hive entranc follow environment gradient arsenophonus emerg possibl indic anthrop gradual decreas abund agricultur natur environ multipl nich import day exposur semi natur landscap hive show intermedi profil suggest allevi microbi dysbiosi reduct anthrop
|
D064307;D014581
|
T001;T047;T032;T028
|
36,336,702
|
co axial acoust base optic coher vibrometri probe quantif reson frequenc mode ocular tissu present co axial acoust base optic coher vibrometri probe coa ocv vibro acoust reson quantif biolog tissu sampl vibrat stimul via loudspeak pre compens use calibr acoust spectrum sampl vibrat measur via phase sensit swept sourc optic coher tomographi oct reson frequenc corneal phantom measur vari intraocular pressur iop depend young modulus e phantom thick iop observ cycl iop reveal hysteresi e mpa reson frequenc increas iop rate hzmmhg vari thick hzmmhg e mpa reson frequenc increas thick rate hzm e mpa hzm e mpa e show predomin impact shift reson frequenc full width half maximum fwhm reson mode increas increas thick decreas increas e thick e contribut varianc fwhm rabbit cornea reson frequenc hz observ result current studi demonstr feasibl coa ocv use futur oct v studi
|
D014732;D007429
|
T070;T042
|
36,336,700
|
novel applic one step pool molecular test maximum likelihood approach estim preval malaria parasitaemia among rapid diagnost test negat sampl western kenya detect malaria parasitaemia sampl negat rapid diagnost test rdts requir resourc intens molecular tool pool test use two step strategi provid cost save altern gold standard individu sampl test statist adjust need improv accuraci preval estim singl step pool test strategi
|
D008288;D016778
|
T047
|
36,336,698
|
revisit multidimension interact model stress anxieti cope covid pandem longitudin studi although multidimension interact model stress anxieti cope mimsac known year lack research examin theori longitudin stress event studi aim revisit mimsac among univers student covid pandem
|
D013315;D000086382
|
T047;T067;T048
|
36,336,697
|
chang self report acceleromet measur physic activ among pregnant tricar beneficiari physic activ recommend pregnant individu prevent excess gestat weight gain howev physic activ assess among militari personnel tricar beneficiari experi uniqu militari lifestyl current studi assess physic activ among pregnant tricar beneficiari activ duti non activ duti measur accelerometri self report data examin potenti predictor physic activ engag third trimest self report data consist accelerometri data expect lower bmi activ duti higher baselin physic activ engag associ higher physic activ week also hypothes accelerometri data would show lower physic activ level self report measur
|
D015444;D061725
|
T061;T060;T056
|
36,336,694
|
impact percept institut deliveri servic util northwest ethiopia health belief model ethiopia strive promot institut deliveri communiti wide program howev home still prefer place deliveri women encourag communiti percept deliveri normal process home ideal environ proport women use institut deliveri servic expect level therefor examin impact percept institut deliveri servic use use health belief model
|
D036861;D011295
|
T061;T058
|
36,336,693
|
infarct quantif cardiovascular magnet reson use standard deviat remot unreli valid multi centr multi vendor data object studi investig variabl agreement common use imag process method n sd remot particular quantifi myocardi infarct late gadolinium enhanc lge cardiovascular magnet reson cmr lge cmr tandem analysi method n sd remot repres current refer standard infarct quantif analyt method util region interest roi defin infarct tissu set number standard deviat sd signal intens remot null myocardium consensus set number sd suppos littl known size locat roi under signal properti lge imag affect result furthermor method frequent use elsewher medic imag often without care valid therefor usag n sd method warrant thorough valid
|
D005682;D009203
|
T196;T130;T047
|
36,336,692
|
polygen risk score improv accuraci clinic risk score coronari arteri diseas valu polygen risk score prss toward improv guidelin recommend clinic risk model coronari arteri diseas cad predict controversi examin whether integr polygen risk score improv predict cad beyond pool cohort equat method observ studi unrel white british uk biobank particip enrol conduct case control sampl preval cad case equal number random select control use tune integr polygen risk score separ cohort individu follow use examin risk predict perform pool cohort equat integr polygen risk score prs enhanc pool cohort equat incid cad case perform model analyz discrimin risk reclassif use threshold
|
D003324
|
T047
|
36,336,690
|
advanc direct among cognit impair person amyloid pet scan care partner mix method studi littl research exist role amyloid pet scan part alzheim diagnost test document end life prefer person cognit impair studi object examin associ amyloid pet scan result elev vs elev amyloid level diagnost categori mild cognit impair vs dementia likelihood advanc direct report median month post scan explor percept pet scan result influenc plan futur among person cognit impair care partner
|
D017028;D060825
|
T099;T098;T097;T048
|
36,336,689
|
gastric duplic cyst ectop pancrea teenag success resect endoscop submucos dissect gastric duplic cyst associ ectop pancrea rare aim alert clinician congenit anomali
|
D000069916;D003560;D007410;D013274
|
T061;T047;T191;T190
|
36,336,688
|
effect bacill calmett guerin vaccin polici reduc infect mortal covid systemat review covid vaccin advoc effect way curb pandem inequit distribut slow rollout especi low middl incom countri still take long time herd immun achiev altern measur must therefor explor bolster current covid vaccin effort particular bacill calmett guerin vaccin studi extens propos confer non specif immun differ infect includ covid aim studi therefor evalu current evid effect nation bcg vaccin polici reduc infect mortal covid
|
D001500;D000086382
|
T129;T121;T116;T067;T047
|
36,336,687
|
iatrogen kaposi sarcoma small bowel crohn diseas follow short term use immunomodul case report review literatur kaposi sarcoma vascular tumor high relat human herpesvirus kaposi sarcoma associ herpesvirus kaposi sarcoma usual manifest skin mucos lesion involv viscer organ gastrointestin tract rare kaposi sarcoma occur immunocompromis patient receiv immunosuppress therapi case known iatrogen kaposi sarcoma drug induc kaposi sarcoma intestin kaposi sarcoma patient inflammatori bowel diseas extrem rare
|
D003424;D012514;D019288;D015212
|
T047;T191;T005
|
36,336,686
|
nutrient dynam coral symbiosi depend relat absolut abund symbiodiniacea speci symbiont provid varieti reproduct nutrit defens resourc host resourc vari depend symbiont communiti composit genet techniqu open eye breadth symbiont divers within myriad microbiom symbiosi research begun consid ecolog mechan affect ident relat abund symbiont speci communiti structur impact resourc exchang among partner manipul hospit densiti relat ratio two speci coral endosymbiont symbiodinium microadriaticum breviolum minutum use stabl isotop enrich trace nutrient exchang host briareum asbestinum
|
D037421;D004141
|
T204
|
36,336,684
|
associ hepat steatosi fibrosi measur insulin sensit patient sever obes type diabet cross section studi obes non alcohol fatti liver diseas nafld insulin resist three patholog condit high correl relationship fulli elucid henc aim assess associ hepat steatosi fibrosi differ measur insulin sensit patient sever obes type diabet mellitus tdm
|
D003924;D007333;D065626;D009767
|
T047;T046
|
36,336,683
|
associ intergener relationship cognit impair among chines adult year age older prospect cohort studi oldest old age older rapid grow age group like suffer cognit impair lead sever medic econom burden influenc intergener relationship cognit among chines oldest old adult clear aim examin associ intergener relationship cognit impair among chines adult age older
|
D060825
|
T048
|
36,336,682
|
automat segment great arteri comput hemodynam assess comput fluid dynam cfd increas use assess blood flow condit patient congenit heart diseas chd requir patient specif anatomi typic obtain segment cardiovascular magnet reson cmr imag howev segment time consum requir expert input studi aim develop valid machin learn ml method segment aorta pulmonari arteri cfd studi
|
D006439;D008279
|
T060;T170;T059;T042
|
36,336,681
|
pten regul invas pancreat neuroendocrin tumor dusp mediat vegfr dephosphoryl phosphatas tensin homolog pten tumor suppressor low pten express observ pancreat neuroendocrin tumor pnet associ increas liver metastasi poor surviv vascular endotheli growth factor receptor vegfr receptor tyrosin kinas usual activ bind vascular endotheli growth factor c vegfc vegfr demonstr lymphangiogenesi cancer invas pten also phosphatas dephosphoryl lipid protein substrat vegfr hypothes substrat pten dual specif phosphatas dusp atyp dusp interact vegfr studi investig function pten regul pnet invas associ vegfr dusp
|
D018358;D010190;D018242
|
T191
|
36,336,680
|
epigenet regul age implic intervent age diseas age accompani declin organism function seri promin hallmark includ genet epigenet alter age associ epigenet chang includ dna methyl histon modif chromatin remodel non code rna ncrna regul rna modif particip regul age process henc contribut age relat diseas therefor understand epigenet mechan age provid new avenu develop strategi delay age inde age intervent base manipul epigenet mechan led allevi age extens lifespan anim model small molecul base therapi reprogram strategi enabl epigenet rejuven develop amelior revers age relat condit addit adopt health promot activ calor restrict exercis calibr circadian rhythm demonstr delay age furthermor various clinic trial age intervent ongo provid evid safeti efficaci therapi review recent work epigenet regul age outlin advanc intervent strategi age age associ diseas better understand critic role epigenet age process lead clinic advanc prevent human age therapi age relat diseas
|
D044127;D000375
|
T033;T045;T040
|
36,336,679
|
global studi associ cesarean rate role socioeconom status neonat mortal rate current centuri caesarean section cs rate signific increas across world past decad present popul base studi sought evalu associ cs neonat mortal rate
|
D002585;D007226
|
T061;T081;T079
|
36,336,678
|
speech silenc charact diagnost biomark earli cognit declin function mechan multicent cross section cohort studi languag deficit frequent occur prodrom stage alzheim diseas ad howev characterist linguist impair under mechan remain explor earli diagnosi ad
|
D060825;D000544
|
T047;T048
|
36,336,676
|
associ physic activ air pollut exposur risk type diabet larg popul base prospect cohort studi interplay physic activ pa air pollut relat type diabet td remain larg unknown base larg popul base cohort studi studi aim examin whether benefit pa respect risk td moder exposur air pollut
|
D000393;D003924;D000397
|
T131;T047;T069;T080
|
36,336,675
|
streptococcus pneumonia mening child idiopath nephrot syndrom case report children nephrot syndrom increas risk infect includ bacteri periton pneumonia cellul howev bacteri mening potenti life threaten complic highlight infecti complic nephrot syndrom recent review report subtl unusu present bacteri mening child nephrot syndrom without high index suspicion would miss
|
D008586;D009404;D016920
|
T047;T050
|
36,336,459
|
rapid chang profil store materi use scent train explos detect dog canin train scent materi emit vapour explos relat compound wide use detect explos civilian militari forens applic despit import train materi limit knowledg long subsampl store whether vapour profil chang time develop sampl methodolog make use secondari chamber stabilis headspac concentr allow reliabl reproduc determin scent profil effect age investig follow respons volatil marker emit eight common explos open close contain two month two year initi headspac air volum consist wide varieti chemic substanc relat explos level vari magnitud low ppb ppm includ subsampl affect age demonstr exponenti lower level five subsampl show signific chang scent profil domin compon decreas short time scale plastic explos base rdx petn dynamit well granul octol ammonium nitrat mix fuel flake tnt granul comp b nitrocellulos powder headspac air concentr declin overal charact profil general stabl overal chang ie lower level andor chang profil justifi regular check scent status train materi consid result togeth data display margin chang energet perform advis complement scent train train materi subject differ durat age
|
D053834
|
T120
|
36,336,458
|
degrad polym banknot handl effect fingermark visualis surfac structur mint issu handl polym five pound sterl banknot studi atom forc microscopi laser scan confoc microscopi total fingermark mint handl banknot four differ issu bank bank england bank scotland royal bank scotland clydesdal bank visualis vacuum metal deposit vmd cyanoacryl fume caf clydesdal bank note magnet fluoresc powder vmd signific effect develop fingermark handl banknot across bank studi although effect vari issu bank exampl handl bank england note mark show ridg detail vmd develop caf bank scotland handl note success rate vmd caf microscopi degrad banknot show loss intaglio print format crack surfac structur handl note featur lead trap powder contamin increas quantiti develop agent fingermark background ridg decreas contrast decreas perform powder base fingermark develop techniqu featur restrict migrat compon fingermark prevent fingermark degrad spread materi thus reduc potenti format empti print vmd develop advers affect
|
D003878;D011108
|
T104;T122;T059;T073
|
36,336,457
|
plan develop method collect ground truth data relat footwear mark evid ground truth data data come known sourc truth data known infer fsr forens scienc regul requir forens unit carri certain forens process undertak test ground truth data purpos qualiti assurancequ control process accredit howev data collect must form meaning dataset enabl relev test perform inform end user technic note discuss forens unit uk plan develop method collect ground truth data footwear mark evid discuss materi variabl consid develop method evid base decis make process enabl creation recommend consider provid assist forens unit collect data relev jurisdict whilst method prescript use guid may facilit develop larg relev nation dataset
|
D044707;D005554
|
T090;T091
|
36,336,456
|
autom detect classif counterfeit banknot use quantit featur captur spectral domain optic coher tomographi counterfeit banknot still sever crime problem mani countri one signific issu solv crime classifi counterfeit type identifi sourc current method classifi counterfeit banknot reli manual examin time consum labor intens moreov method detect surfac featur easili imit advanc print technolog studi autom method base optic coher tomographi oct machin learn algorithm propos classifi differ type banknot base intern featur spectral domain oct sd oct system employ sub surfac imag quantit assess banknot total chines yuan banknot collect real counterfeit three differ print process banknot imag time distinct region result dataset sampl sampl character extract scan oct signal intens along depth base featur b scan cross section oct imag base featur sever machin learn model includ logist regress lr support vector machin svm k nearest neighbor knn random forest rf built optim classifi train use sampl appli predict test sampl best perform achiev svm classifi sensit specif obtain discrimin authent counterfeit banknot sensit specif obtain predict type counterfeit banknot classifi also evalu use receiv oper characterist roc curv best knowledg first studi scan b scan deriv featur oct imag use detect classif differ type counterfeit banknot
|
D041623;D000465
|
T060;T170
|
36,336,455
|
novel recoveri method biolog materi case alleg sexual assault word caution mani believ increas public confid investig sexual crime convict rate lead increas report crime consequ forens scienc provid continu strive make improv evid recoveri examin subsequ interpret evid one develop method enabl individu self sampl howev case complain self sampl question sampl taken store legitim rais addit continu integr evidenti sampl may question result accept court potenti evid could therefor lost larg emot psycholog impact sexual assault rape complain report sexual assault recov materi evid inadmiss court specialis unit victim alleg sexual violenc avail offer far recoveri evidenti sampl commentari behalf faculti forens amp legal medicin fflm associ forens scienc provid bodi fluid forum afsp bff highlight need care victim sexual assault evid recov case alleg sexual assault sexual violenc obtain line best practic protocol
|
D019548;D012742;D011902
|
T098;T054;T037;T068;T048
|
36,336,454
|
effici method detect seri fraudul ident document base digitis forens data document fraud transnat form crime serial charact alreadi highlight combat phenomenon interst databas fraudul ident document bidif creat implement switzerland support comparison document detect seri ie document share common sourc effici use system forens document examin would benefit harmonis proven profil method thus aim studi develop method compar document establish seri method meant improv detect capabl forens document examin oper bidif engag profil fraudul document first method base visual characterist digitis imag fraudul ident document develop subsequ method qualit quantit evalu use four test first test verifi abil method detect pre exist seri second test check capabl method detect link amongst isol document final two test carri compar method impact success detect seri test carri profession forens document examin master student forens scienc respect allow comparison method influenc seri detect method allow signific increas number seri link detect also decreas occurr fals negat fals posit furthermor link rapid detect
|
D005554;D044707
|
T090;T091
|
36,336,453
|
depth investig capabl limit combin proteom maldi ms base approach forens detect blood past year matrix assist laser desorpt ionis mass spectrometri maldi ms base method develop publish forens detect blood stain fingermark howev view adopt oper context investig capabl limit approach must conduct refin test approach must also tailor requir end user enabl address specif circumst encount forens scenario present studi delv deeper assess applic maldi ms base strategi reliabl robust detect human blood semi qualit assess sensit method ii wider investig compat method prior applic common use presumpt test iii assess specif method blood present mixtur biofluid robust assess blood detect rang porous materi find strengthen evid support adopt maldi ms base approach confirmatori test forens detect human blood oper context
|
D040901;D005554
|
T091
|
36,336,452
|
hierarchi case prioriti hicap propos method case prioritis digit forens laboratori need digit forens scienc dfs servic grown due widespread consist engag technolog member societi whilst digit evid often play import role mani inquiri avail investig resourc fail keep pace demand result use case prioritis model backlogworkload manag increas import ensur effect deploy laboratori resourc work focus concept case prioritis digit forens laboratori set follow submiss exhibit examin workflow describ challeng case manag prioritis laboratori discuss case accept case prioritis procedur explain final hierarchi case prioriti hicap transpar risk base approach prioritis case examin propos describ use exampl
|
D007753;D005554
|
T091;T073;T093
|
36,336,451
|
applic dual energi x ray soil screen forens archaeolog need forens search soil small artefact burial site trace evid deposit site common task share investig forens archaeologist forens casework import find small piec evid person effect ballist fragment overst assist posit identif deceas give insight manner caus death identifi perpetr soil search method known wet dri siev cumbersom time consum limit success soil type often lead decis search result miss opportun identifi potenti evid primari aim studi investig dual energi x ray baggag scanner could use search item potenti forens interest soil trial conduct use smith detect scantrail v mobil x ray inspect system establish could use detect organ inorgan metal item locat within soil soil type natur variabl water organ content adjust simul differ environ baggag scanner found provid quick easi way detect item contain within various soil type particular sand rich matrix estim use method search soil broken sampl lt cm depth would take around one hour complet compar person hour manual siev believ first use dual energi x ray technolog purpos show potenti research use method forens archaeolog
|
D012987;D001106
|
T090;T091;T167
|
36,336,450
|
empir studi close rang post ricochet orient ak bullet mm mm injuri death ricochet bullet shoot incid usual report due misaim shot ricochet close victim although destabilis ricochet bullet ricochet flight general known phenomenon signific quantit base scientif studi attempt understand bullet post ricochet orient close distanc empir studi explor close rang post ricochet orient ak bullet mm mm rang domest surfac type typic encount bullet ricochet incid studi reveal ricochet ak bullet various wood type tile sampl produc side impact close locat target follow rightward yaw action also shown ak bullet ricochet concret cement sampl degre incid angl produc nose forward impact paper wit screen similar orthogon impact direct fire shot find present import new inform post ricochet yaw behaviour ak bullet potenti aid futur shoot reconstruct victim hit close ricochet bullet
|
D005389;D014948
|
T073;T037
|
36,336,449
|
preliminari investig use recov latent fingerprint technolog unfir ammunit fire cartridg case previous studi identifi potenti benefit disulfur dinitrid sn process oper relev substrat howev major work conduct prototyp equip substanti differ commercialis system recov latent fingerprint technolog lft term design chemic deliveri paper evalu perform recov lft problemat exhibit encount within fingerprint enhanc laboratori unfir fire ammunit three pseudo oper experi involv non groom natur handl fingermark conduct common encount type ammunit use crime unit kingdom uk addit recov lft compar superglu fume follow basic yellow fluoresc dye stain common use altern ascertain process provid ad benefit fingermark recoveri rate result show fingermark visualis small calibr cartridg case remain difficult mark achiev enough ridg detail comparison howev paper also show novel recov lft process still infanc requir optimis wors current implement visualis process therefor worth investig
|
D003878;D005389
|
T059;T073
|
36,336,448
|
detect analysi dna mixtur miseq fgx recogn interpret mixtur challeng occur frequent forens casework therefor new analysi method implement must handl challeng mix forens sampl next generat sequenc offer advantag capillari electrophoresi amplicon multiplex degrad sampl analysi howev advantag mix sampl reli heavili advanc user friend analysi softwar research analyz sampl forenseq dna signatur prep kit miseq fgx compar globalfil str kit capillari electrophoresi metric test chemistri includ concord limit detect mixtur analysi data analysi mixtur sampl complet mixtureac plug armedxpert softwar next generat sequenc offer distinct advantag limit detect isoallel heterozygos suffer increas variabl stutter allel count ratio compar capillari electrophoresi
|
D016172;D018895
|
T063;T123;T034;T114
|
36,336,447
|
guid proposit set forens dna interpret general reluct use condit profil form proposit case evid dna mixtur howev use condit profil improv abil differenti true fals donor least four situat decis make difficult rigor mathemat treatment given slooten other appear offer strong guidanc situat treatment assum prior probabl condit condit individu extrem prior probabl appear ambigu decis condit appear problemat often situat found casework paper attempt show situat may benefit follow guidanc lower bound bay factor obtain find highest lr includ poi divid highest lr includ poi two highest lrs may found without disput condit profil result lower bound bf inclus poi without direct assum disput condit profil adopt approach would minim adventiti inclus approxim exhaust set proposit
|
D016172;D004247
|
T063;T123;T034;T114
|
36,336,446
|
applic treadmatch scan aid process footwear mark comparison current uk person arrest charg record offenc print footwear taken whilst custodi tread pattern record print search use nation footwear databas find footwear pattern recov previous crime scene generat forens intellig treadmatch digitis system collect footwear print seiz detaine custodi purpos whilst use generat intellig accept valid experi conduct understand level perform assist forens comparison purpos identif absenc incorpor scale known well treadmatch reproduc pattern size tread threaten valid comparison determin measur treadmatch scan consist common use aluminium powder test mark could save polic time resourc digit scan could use preliminari assess prior footwear physic submit evidenti comparison therefor studi set compar three differ type treadmatch scan dynam zoom roll thirti differ piec footwear test mark footwear use tradit method fingerprint powder length width measur obtain tread pattern use gnu imag manipul program softwar result data analys assess agreement treadmatch scan test mark use intraclass correl coeffici icc bland altman plot limit agreement loa addit intra sampl studi use fifteen repeat measur piec footwear differ treadmatch scan method carri support larger valid studi icc result coeffici rang across measur loa display close agreement less agreement variat display test mark treadmatch roll scan length width measur variat hand roll print must taken consider standard approach develop studi suggest treadmatch use preliminari assess assist forens comparison particular dynam zoom print
|
D012775;D005554
|
T091;T073
|
36,336,445
|
entomolog identif post mortem colon wolf cadav differ decomposit stage human driven biodivers loss progress becom problem dramat consequ conserv vital ecosystem increas number illeg kill grey wolf cani lupus linnaeus threaten speci display need investig prosecut offenc forens entomolog make use knowledg necrophag insect estim minimum time sinc death interv deceas person anim give import inform possibl perpetr cadav fauna along five decomposit stage wolv germani investig period insect wolf cadav origin germani provid leibniz institut zoo wildlif research berlin accumul degre day add model appli post mortem interv estim wolf cadav first time total coleopteran speci differ dipteran speci discov identifi almost insect specimen order diptera beetl coleoptera account cadav fauna blowfli calliphorida particular import forens issu account famili carrion beetl silphida found second abund famili addit combin case steadili increas insect speci rich detect earli decay advanc decay fresh bloat activ decay advanc decay follow remain stage speci number decreas howev signific differ number speci found stage decay case consid individu tempor pattern insect appear found congruent previous studi furthermor time death determin case compar pathologist estim studi provid insight arthropod fauna wolf remain first time appli add model post mortem interv estim discuss suitabl forens entomolog wildlif death investig
|
D019596;D004175;D001517
|
T015;T204
|
36,336,444
|
tool rubbish digit forens practition often utilis rang tool throughout casework order access identifi analys relev data make vital part conduct thorough effici accur digit examin devic content dataset whilst import underst also guarante function free error similar practition assur perform flawless error occur investig assum identifi determin caus import purpos ensur qualiti control immedi investig longer term practic improv perhap anecdot start posit postmortem review error may suspect tool use may fault recent narrat initi enforc need evalu tool prior use live investig yet addit error may occur result practition investig conduct work discuss concept fault attribut focus role forens tool practition propos seri principl determin respons investig error
|
D005554
|
T091
|
36,336,443
|
swap carrot stick forens scienc provid view forens regul act april forens scienc regul act receiv royal assent provid new statutori power forens scienc regul fsr england wale power intend enabl fsr compel forens scienc provid fsps compli qualiti standard requir fsr reli upon soft power argument benefit gain fsps achiev accredit adher code practic reach limit persuas power fsr act introduc power penalis fsps remain unaccredit fall publish standard gaug potenti impact forens scientist ask anticip effect act practition indic new statutori power could instil sens urgenc among polic forc forens scienc unit particular prioritis qualiti invest accredit howev signific capac limit may hamper widespread sustain chang financi pressur face fsps well resourc constraint within fsr role chang regulatori approach focuss upon voluntari cooper support encourag intrins motiv ie carrot one reliant upon deterr form threat sanction punish stick could prevent real improv qualiti undermin achiev regulatori aim fsr act unabl address problem forens scienc provis milit qualiti forens scienc servic thus benefit accru swap carrot stick may illusori may ultim prove counterproduct
|
D018552
|
T168;T002
|
36,336,442
|
preliminari studi investig overlay method forens podiatri comparison insol footprint overlay method use forens podiatri compar shape posit overal fit featur question refer footprint evid howev scientif foundat underpin valid comparison insol footprint fulli understood lack publish data defin statist oper paramet review literatur reveal subject natur littl scientif valid limit face valid aim studi investig strength agreement three expert footprint examin overlay comparison ten refer insol footprint use cohen weight kappa kw valid method explor use measur sensit specif fals posit rate fpr fals negat rate fnr receiv oper characterist roc curv area roc curv auc result show two examin demonstr high inter rater consist overlay comparison kw ci rater v rater whilst one examin kw ci rater v rater kw ci rater v rater valid investig use conclus scale verbal express tabl indic support reject compat footprint one question insol ten refer insol data analysi indic valid follow sensit specif fpr fnr roc analysi corrobor find auc calcul indic accept measur overal accuraci overlay method insol footprint comparison find provid novel data support previous suggest overlay method use isol compar insol footprint data also offer insight scientif foundat method whilst highlight limit provid implic recommend forens podiatri practic
|
D011032
|
T091
|
36,336,441
|
chemic trace xrf analysi detect sharp forc trauma fresh burn bone forens anthropologist may alway abl differenti heat induc fractur fractur aetiolog name sharp forc trauma clear nefari impact medico legal conclus object studi experiment investig blade chemic trace transfer deflesh bone tissu remain burn event accomplish prompt sharp forc trauma macer fresh pig rib five differ instrument name stainless steel knife artisan knife ceram kitchen knife small axe larg axe anoth pig rib use control subject trauma instrument probe x ray fluoresc xrf establish composit blade bone sampl pre burn post burn c c c c probe xrf sharp forc instrument left detect chemic trace pre burn bone although sampl furthermor trace still detect experiment burn case potenti xrf provid relev inform aetiolog fractur burn unburn bone although effect soft tissu diagenesi must still investig
|
D002056
|
T037
|
36,336,440
|
time burnt away impact heat induc chang skelet age death diagnost featur paper investig establish notion bone calcin major impact age estim low intens burn mere neglig impact systemat research carri far topic true impact heat induc chang diagnost age featur most unknown agreement pre burn post burn observ age featur investig human skeleton male femal age death rang year old subject experiment burn skeleton belong st centuri identifi skelet collect hous laboratori forens anthropolog depart life scienc univers coimbra portug suchey brook method base pubic symphysi method develop auricular surfac buckberri chamberlain scrutin suchey brook method provid better agreement pre post burn observ method buckberri chamberlain howev becam clear heat induc chang affect method regardless heat intens sinc calcin bone bone burnt lower intens often show less perfect agreement therefor research demonstr analysi age death impair burnt bone even subject calcin clear impact forens archaeolog investig
|
D000365;D011631
|
T060;T034;T030
|
36,336,437
|
kidney diseas sar cov infect challeng consider nurs covid pandem disproportion affect individu kidney diseas caus signific morbid mortal worldwid sar cov infect link develop acut kidney injuri worsen under kidney function multipl challeng encount covid pandem result valuabl lesson learn futur pandem public health emerg disast relat care individu kidney diseas covid pandem expos extens need nurs knowledg care kidney diseas abl provid special nephrolog care
|
D000086382;D058186
|
T047;T037;T067
|
36,336,436
|
palliat care nephrolog patient intens care unit nephrologist palliat care specialist frequent consult patient admit intens care unit suffer acut kidney injuri end stage kidney diseas dialysi continu predomin treatment recommend kidney failur despit age popul increas incid comorbid condit research show patient request prognost inform dialysi surviv rate initi treatment howev mani patient initi dialysi naiv increas morbid mortal palliat care collabor nephrolog help improv communic focus share decis make
|
D009398;D007676
|
T047;T091
|
36,336,435
|
onco nephrolog critic care set recogn treat renal manifest cancer oncolog emerg onco nephrolog focus care patient cancer kidney diseas patient acut kidney injuri tumor lysi syndrom malign associ hypercalcemia frequent treat critic care set oncolog emerg high mortal rate prompt recogn appropri treat critic care nurs knowledg regard risk factor clinic manifest laboratori abnorm common renal manifest malign oncolog emerg optim care improv patient outcom
|
D009398;D009369;D058186
|
T047;T191;T091;T037
|
36,336,434
|
optim care kidney transplant articl provid fundament inform health care provid kidney transplant review preoper test postop complic treatment help help assist postop care kidney transplant ensur care optim articl help educ inform caregiv guidelin suggest plan care follow best outcom transplant recipi short long term care patient extrem import health care provid need follow practic guidelin achiev optim outcom discuss benefit anyon direct care transplant recipi includ limit nurs staff nurs aid train physician general practition mid level provid
|
D016030
|
T061
|
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