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biomedical-topic-categorization-validation

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36,336,432
geriatr nephrolog older adult receiv critic care high risk acut kidney injuri aki mani reason import critic care nurs know skill address risk factor conduct comprehens geriatr assess implement evid base intervent articl provid review inform
D009398;D058186
T047;T091;T037
36,336,431
fluid overload volum overload common complic multitud diseas state well complic mani medic therapi critic ill patient intens care unit volum overload especi concern persist past first day admiss set chronic kidney diseas mainten fluid balanc present addit challeng articl focus caus volum overload well treatment option critic ill patient includ nuanc kidney patient end outpati guidelin recommend avoid recurr
D016638;D058186
T047;T037
36,336,430
complic patient chronic kidney diseas chronic kidney diseas ckd widespread condit predispos patient myriad complic includ cardiovascular diseas electrolyt acid base derang anemia miner bone diseas volum excess frequenc ckd complic increas stage diseas becom near ubiquit later stage complic ckd profound implic patient manag laboratori monitor medic prescrib follow manag ckd seek slow diseas progress mitig risk pose complic
D051436;D000740;D002318
T047
36,336,429
cardioren syndrom evalu manag cardioren syndrom crs describ disord effect critic ill hospit patient concurr heart kidney dysfunct presenc crs associ poor prognosi articl review epidemiolog patholog evid base evalu manag strategi cardioren syndrom nurs understand signific chronic heart kidney diseas upon patient risk crs regist advanc practic nurs maintain knowledg skill understand patholog crs improv evalu manag patient present crs
D059347;D006333
T047;T046
36,336,428
hypertens articl seek inform reader global burden hypertens highlight need therapi reduc societ cost mortal associ hypertens hypertens worldwid health concern intern european evid guidelin incorpor high qualiti evid generat synthes unit state togeth guidelin broaden understand hypertens best manag diseas base upon realist resourc avail across countri region resourc limit avail
D006973
T047
36,336,425
leishmaniasi leishmaniasi caus leishmania infantum import zoonot diseas transmit sand fli high preval infect dog cat region wherebi transmiss occur clinic diseas system variabl present sign degre sever affect skin lymph node eye bone marrow kidney organ clinic find dog cat l infantum infect general similar subclin infect canin felin endem area frequent long term treatment diseas allopurinol combin allopurinol meglumin antimoni miltefosin need clinic relaps probabl
D002371;D004283;D007896;D018314
T047;T204
36,336,424
hepatozoonosi dog cat hepatozoon cani hepatozoon americanum tick born infect dog transmit differ tick speci dissimilar geograph distribut target organ clinic syndrom h cani transmit most brown dog tick rhipicephalus sanguineus sensu lato affect hemolymphoid organ associ anemia hematolog abnorm wide preval global wherea h americanum transmit gulf coast tick amblyomma maculatum caus sever myositi emerg parasit southern unit state treatment infect decreas parasit load without elimin domest cat infect hepatozoon speci
D048508;D002371;D004283;D016783;D003048
T047;T204
36,336,423
hemotrop mycoplasma hemoplasma infect erythrocyt infect cat dog common often associ diseas cat mycoplasma haemof pathogen speci cat caus hemolyt anemia fever immunocompet host wherea mycoplasma haemocani usual result hemolyt anemia splenectom immunocompromis dog diagnosi polymeras chain reaction blood sampl cytolog unreli prompt treatment clinic diseas support care least week doxycyclin usual success transmiss pathway confirm indirect via vector direct via bitesfightspred like
D009175;D002371;D009174;D000743;D004283
T047;T007
36,336,422
emerg spot fever rickettsios unit state spot fever rickettsios import caus emerg infecti diseas unit state elsewher rocki mountain spot fever caus r rickettsii caus febril acut ill dog circul peripher blood low copi number acut natur diseas dog may test pcr seroneg time present therefor therapi doxycyclin must initi continu base clinician index suspicion combin pcr serolog test repeat test pre antimicrobi blood sampl test convalesc sampl seroconvers facilit diagnosi prognosi excel appropri antimicrobi therapi begun time fashion well establish dog sentinel infect peopl household communiti whether r rickettsii caus ill cat well establish role spot fever group rickettsia caus ill dog cat elucid veterinarian keep mind novel well character speci sfg rickettsia import caus emerg infecti diseas veterinarian play import role detect defin prevent ill canin patient human companion
D021821;D002371;D004283;D012282;D012373;D000073605;D012281
T047;T007
36,336,421
schistosomiasi unit state canin schistosomiasi well establish caus granulomat enteropathi hepatopathi dog small subset patient infect trigger signific hypercalcemia clinic sign clinicopatholog find fair nonspecif ultrasonograph evid heterogen small intestin wall layer pin point hyperecho foci bowel node liver high suggest infect sensit commerci avail fecal polymeras chain reaction test use establish diagnosi treatment protocol reli praziquantel fenbendazol dog recov although retreat may necessari substanti proport housem screen infect asymptomat
D004283;D012552;D006934
T047
36,336,420
veterinari chaga diseas american trypanosomiasi unit state veterinari chaga diseas persist threat human dog wild domest mammal live infect triatomin kiss bug insect vector occur across america includ state southern unit state anim infect trypanosoma cruzi parasit may asymptomat may develop myocard heart failur sudden death difficult prevent anim contact vector endem sylvat environ often dispers domest habitat challeng diseas manag includ imperfect diagnost test limit antiparasit treatment option
D014355;D014224;D014349;D004283
T047;T204
36,336,419
ehrlichiosi anaplasmosi updat canin ehrlichiosi anaplasmosi zoonot tick born diseas broad distribut advanc diagnost enhanc understand speci rickettsi organ involv expand geograph distribut impact health dog cat peopl clinic remiss achiev appropri antimicrobi therapi optim treatment modal elimin infect remain somewhat uncertain protect vaccin ehrlichiosi anaplasmosi remain elus review provid practic veterinarian current inform transmiss diagnosi manag ehrlichiosi anaplasmosi dog cat
D000712;D002371;D004283;D016873
T047
36,336,418
cytauxzoonosi cytauxzoon feli hematoprotozoan parasit complex life cycl involv tick vector mammalian host mammalian host felida bobcat reservoir host parasit typic caus brief self resolv ill follow prolong subclin infect domest cat howev infect often lead acut febril ill character sever morbid mortal diagnosi base microscop identif parasit molecular test treatment ill cat expens difficult often unsuccess prevent quit possibl depend avoid feed vector tick
D011529;D016792;D046008;D013987;D002371
T047;T015;T204
36,336,417
babesia north america updat canin babesiosi result infect identifi protozo speci unit state babesia conrada babesia sp coco babesia gibsoni babesia voge babesia vulp part apicomplexa famili protozoa oblig intraerythrocyt parasit domest wild canid suspect intermedi host updat articl aim provid practic guidanc clinic manifest diseas treatment option outcom addit author hope provid clariti taxonomi nomenclatur organ undergon multipl chang sinc initi discoveri
D001403;D001404;D004283
T047;T204
36,336,416
bartonellosi dog cat updat uniqu virul factor bartonella spp make stealth pathogen evad immun system caus persist infect often difficult diagnos treat understand pathogen mechan allow clinician recogn pursu diagnost optim diagnost test treatment ultim lead improv outcom
D001474;D002371;D004283
T047
36,336,415
chang tick born diseas preval dog affect diagnost test ixod scapulari deer tick amblyomma americanum lone star tick rhipicephalus sanguineus brown dog tick tick common parasit dog unit state first part articl examin chang epidemiolog illustr awar distribut adapt diagnost test includ broad rang pathogen may improv abil identifi help infect patient especi suspect idiopath immun mediat diseas discuss optim test pathogen use avail panel
D048508;D017282;D004283
T047;T204
36,336,411
core level ionize excit auger relax induc cluster dna damag ioniz radiat caus various type dna damag singl ssbs doubl strand break dsbs nucleobas lesion abas site ap site cross link complementari strand dna dna protein dsbs among harm type dna damag induc serious genet effect cell lethal mutat nucleobas lesion ap site hand may less deleteri prompt repair base excis repair ber pathway recent biochem approach quantifi nucleobas lesion ap site reveal certain type non strand break lesion harm dna damag call cluster dna damag cluster retard nucleobas excis repair enzym sometim convert dsbs ber catalysi uniqu charact cluster dna damag strong depend spatial densiti ionize excit event occur track end initi radiat low energi secondari electron particular photoelectr effect element compris biolog molecul follow emiss auger electron key factor determin futur fate cluster damag site chapter describ biolog studi cluster nucleobas lesion ssbs ap site mechanist studi core level excit auger relax give rise cluster dna damag
D004249;D004260
T045;T049
36,336,410
quantit evalu dna doubl strand break dsbs singl molecul observ adapt method singl molecular observ individu dnas shown reliabl analysi doubl strand break dsbs becom possibl various kind damag sourc singl dna size sever ten kilo base pair exhibit length scale sever indic whole conform visibl fluoresc microscopi ad suitabl fluoresc dye solut various exampl quantit evalu dsbs describ togeth evalu protect effect anti oxid
D053903;D004249
T049
36,336,409
dna damag biolog respons induc boron neutron captur therapi bnct boron neutron captur therapi bnct tumor cell select high let linear energi transfer particl beam therapi patient administr boron b compound via intraven inject infus b suffici accumul tumor neutron beam contain epitherm neutron main compon irradi epitherm neutron lose energi bodi becom thermal neutron captur b undergo n reaction thermal neutron result particl li nuclei short rang respect reach surround cell normal tissu therefor high let heavi charg particl select kill cancer cell cell kill effect heavi charg particl thought trigger dna damag known dna damag caus heavi charg particl serious difficult repair dna damag caus low let radiat x ray ray review focus dna damag eg dna strand break dna damag repair caus bnct describ result biolog respons
D016754
T061
36,336,408
mechan forc induc dna doubl strand break ultrasound sinc applic ultrasound clinic diagnosi therapeut purpos increas rapid effect exposur ultrasound dna molecul studi chapter introduc various effect dna damag caus differ condit exposur ultrasound ultrasound differ sound pressur puls transmiss condit appli studi discuss threshold sound pressur ultrasound induc dna damag differ kind puls ultrasound microbubbl influenc dna doubl strand break also shown
D004249;D004247
T049;T123;T114
36,336,407
chromatin organ dna damag genom dna organ three dimension nucleus chromatin recent accumul evid demonstr chromatin organ numer dynam domain higher eukaryot cell act function unit genom compact domain facilit dna replic gene regul undamag chromatin critic healthi cell function divid howev cellular genom constant threaten mani sourc dna damag eg radiat cell maintain genom integr subject dna damag chapter describ compact state chromatin safeguard genom radiat damag chemic attack togeth recent genom data find suggest dna compact chromatin domain format play critic role maintain genom integr format domain limit dna access insid domain hinder recruit repair machineri damag site dna repair approach issu first describ sensit imag method detect chang chromatin state live cell singl nucleosom imagingtrack use method explain cell overcom potenti recruit difficulti cell decompact chromatin domain follow dna damag temporarili increas chromatin motion dna access perform effici dna repair also specul chromatin compact affect dna damag resist clinic set
D004249;D002843
T049;T116
36,336,406
damag dna tritiat water tritium radioisotop hydrogen emit low energi ray disintegr dna molecul damag main ray irradi addit damag induc break chemic bond nuclear transmut inert deep knowledg mechan under dna damag lead better understand biolog effect tritium chapter review recent experiment comput simul activ quantit evalu damag rate ray irradi nuclear transmut rate dna doubl strand break tritiat water examin use singl molecul observ method effect ray irradi notic level tritium concentr kbqcm irradi effect clear tritium concentr mbqcm factor affect dsb rate discuss new imag process method automat measur dna length use opencv deep learn also introduc effect tritium transmut hydrogen bond act two main strand dna examin use molecular dynam simul studi show collaps dna structur transmut quantit evalu use root mean squar deviat atom posit
D014867;D004247
T121;T197;T123;T114
36,336,405
carbon ion radiat cluster dna doubl strand break carbon ion categor heavi ion particl use cancer radiotherapi high linear energi transfer let carbon ion irradi deposit energi high densiti along particl track generat multipl type dna damag complex dna lesion compris dna doubl strand break dsbs singl strand break base damag within helic turn mbp chapter review hallmark cluster dsbs dna damag influenc genom instabl cell viabil context high let carbon ion radiotherapi
D053903;D063193
T061;T049
36,336,404
auger electron dna doubl strand break studi use iodin contain chemic irradi high z element iodin gold gadolinium monochromat x ray caus photoelectr effect includ releas auger electron decay radioact iodin also result multipl event involv generat auger electron electron low energi travel short distanc strong effect dna damag includ generat doubl strand break chapter focus iodin discuss various studi use iodin contain chemic generat auger electron caus dna doubl strand break first dna synthesi precursor contain iodin use place iodin dna dna bind dye iodin hoechst investig auger electron generat dna break recent iodin contain nanoparticl develop describ studi use tumor spheroid load iodin nanoparticl synchrotron generat monochromat x ray studi led demonstr optimum effect dna doubl strand break format observ kev x ray k edg energi iodin
D007455;D013964
T123;T196;T121;T191
36,336,403
overview dna damag doubl strand break dna varieti assault result differ damag accumul dna includ base chang singl strand break doubl strand break volum also briefli follow volum discuss dna damag doubl strand break particular focus doubl strand break discuss type doubl strand break well method detect also discuss dna break form
D004249;D004260
T045;T049
36,336,400
comprehens overview autoantibodi isotyp subclass distribut presenc autoreact antibodi hallmark mani autoimmun diseas effector function auto antibodi determin constant domain defin antibodi isotyp subclass preval isotyp serum igg often isotyp use diagnost test nevertheless autoantibodi respons uniqu isotypesubclass profil compar autoantibodi isotyp profil may yield new insight diseas pathophysiolog summar isotypesubclass profil promin autoantibodi despit substanti variat within autoantibodi respons unpreced comparison show autoantibodi share distinct isotyp pattern across differ diseas although autoantibodi respons domin igg main igg sever specif diseas character predomin igg diseas ige play key role import share featur autoantibodi isotypesubclass profil seen clinic unrel diseas suggest potenti common trajectori respons evolut diseas pathogenesi treatment respons isotyp beyond igg scarc investig mani autoantibodi respons leav substanti gap understand pathophysiolog autoimmun diseas futur research address isotypesubclass profil detail incorpor autoantibodi measur beyond total igg diseas model clinic studi
D001323;D001327
T129;T047;T116
36,336,399
adapt world determin plastic follicular helper cell antibodi crucial host defens well allerg diseas follicular helper tfh cell play essenti role germin center reaction facilit b cell differenti immunoglobulin affin matur isotyp switch although tfh cell uniqu gene transcript program regulatori network recent increas evid tfh cell plastic tfh cell express gene typic relat type effector cell associ differ type ig subclass context differ pathogen infect health condit review plastic tfh cell various type immun respons also point import implic tfh plastic understand treat human diseas includ allergi
D006377;D000084522
T025
36,336,392
elder abus elder abus defin harm inflict older person relationship expect trust andor person target base age disabl challeng clinician identifi radiologist help rais appropri suspicion elder abus base patient imag articl review common distribut radiograph pattern injuri sustain physic elder abus also discuss limit uniqu challeng radiolog assess elder abus includ issu communic frontlin provid broad overlap appear abus accident injuri set old age decondit
D004552
T054;T048
36,336,391
updat role imag detect intim partner violenc intim partner violenc ipv major public health problem advers health mental consequ patient clinician relat barrier screen includ underreport misattribut ipv caus patient seek help face social stigma discrimin radiolog may help overcom barrier object imag evalu note mismatch imag find provid clinic histori recogn injuri pattern specif ipv imag aid earli identif intervent even patient forthcom articl examin way radiologist adapt meet ever increas demand diagnosi report ipv
D000066511
T053
36,336,390
use enter contrast emerg set histor comput tomographi abdomen pelvi perform routin enter contrast help improv diagnost accuraci howev util enter contrast call question recent particular high patient volum set emerg depart articl review role enter contrast emerg set particular emphasi given specif clinic scenario enter contrast provid valu includ identif abdomin postsurg complic anastomot leak fistula detect penetr bowel injuri evalu acut append assess small bowel obstruct
D003287;D014950
T130;T037
36,336,389
multienergi comput tomographi applic trauma comput tomographi ct play import role trauma imag find direct impact manag advanc ct technolog specif multienergi ct allow simultan acquisit imag low high kilovolt peak techniqu allow differenti materi given materi differ absorpt behavior various multienergi ct postprocess applic help set trauma includ bone subtract virtual monoenerget imag iodin select imag virtual noncontrast imag techniqu appli head toe use improv imag qualiti increas conspicu injuri increas diagnost confid
D014057;D007455
T060;T123;T196;T121
36,336,388
imag soft tissu infect although superfici infect often diagnos manag clinic physic examin may lack sensit specif imag often requir evalu depth involv identifi complic depend area involv radiographi ultrasound ct mr imag combin imag modal may requir soft tissu infect nonnecrot necrot later morbid rapid cours infecti tenosynov common affect flexor tendon sheath hand character thicken enhanc synovium fluid fill tendon sheath
D018461;D002062;D013717
T047
36,336,387
comput tomographi angiographi peripher vascular injuri peripher vascular injuri rare find set trauma import sourc morbid mortal present fast accur diagnosi follow rapid repair vascular injuri import achiev best clinic outcom advanc comput tomographi ct decad experi vascular imag allow radiologist becom import contributor diagnosi character peripher vascular injuri review epidemiolog peripher vascular injuri indic imag way optim ct techniqu imag find common challeng accur diagnosi injuri
D057772
T037
36,336,386
imag trauma pregnanc pregnant patient acut trauma common encount clinician radiologist multidisciplinari approach key although radiographi ultrasound examin frequent use modal set matern fetal trauma fear radiat preclud carri thorough diagnost workup patient comput tomographi scan mri main serv problem solv follow modal stabil mother fetal well assess extern fetal monitor dedic obstetr ultrasound examin radiologist familiar sonograph comput tomographi find catastroph entiti
D016216;D008279
T060;T170;T059
36,336,385
understand ballist injuri understand pathophysiolog diseas allow physician make diagnosi alter natur cours develop implement appropri prevent manag strategi ballist injuri understand mechan injuri translat injuri observ make possibl make sens time complex imag appear mitig long term complic gunshot wound articl author describ differ type ballist projectil mechan injuri well injuri pattern caus addit lead arthropathi mr imag safeti patient retain ballist debri discuss
D014948
T037
36,336,383
multi energi ct applic problem solv emerg radiolog multi energi comput tomographi technolog increas use emerg room er set mani applic impact patient care includ virtual monoenerget imag materi specif imag import radiologist understand technolog optim use er set
D014057;D011871
T060;T091
36,336,380
treatment covid convalesc plasma patient humor immunodefici three consecut case review literatur patient lack humor respons suggest develop less sever covid report prolong relaps dead cours april grow evid benefit covid convalesc plasma ccp patient humor immunodefici congenit primari immunodefici treatment anti cd antibodi report three patient treat hospit review thirti one case describ literatur patient three resolv clinic pictur ccp dose ml enough case antibodi level transfus negat low suggest consumpt sar cov neutral patient protract clinic cours shorten ccp ccp could help patient humor immunodefici avoid relaps chronif ccp transfus earli possibl patient covid humor immunodefici
D000086382
T047;T067
36,336,379
stool donor recruit one year experi stool donor fecal microbiota transfer fmt rigor screen identifi disord health status success screen protocol identifi elig donor last year half evalu compar publish literatur target popul medic student respond public call donat stool qualifi donor brought stool sampl lab student respond call enrol studi donor deliv least one stool sampl main reason volunt exclus bodi mass index bmi kgm n identif esbl escherichia coli fece n success rate screen protocol consid high understand incent particip critic success recruit strategi fmt still littl known practic general popul
D003015;D064307
T032;T028;T037;T047;T001
36,336,378
evalu five immunoassay one later flow immunochromatographi anti sar cov antibodi detect order deal current pandem caus novel sar cov coronavirus sever serolog immunoassay recent develop object use complementari diagnost tool support rt pcr techniqu current consid gold standard method howev new assay need evalu valid purpos studi assess perform five immunoassay two elisa three clia assay one rapid immunochromatograph test detect anti sar cov antibodi
D000086402;D000086382
T005;T067;T047
36,336,375
inter agenc perspect translat advanc biomark discoveri medic countermeasur develop terrestri space radiat environ past year us govern made signific stride establish research fund initi portfolio consist subject matter expert radiat induc biolog effect normal tissu research support nation cancer institut nci provid much earli find identifi cellular pathway involv radiat injuri due need push boundari kill tumor cell minim damag interven normal tissu protect normal tissu surround tumor physician deliv higher radiat dose tumor reduc advers effect relat treatment initi reli critic nci research nation institut allergi infecti diseas niaid first task develop radiat medic countermeasur provid bridg fund move basic research toward advanc develop translat goal niaid program fund approach one day employ protect civilian popul radiolog nuclear incid addit realiti long term space flight possibl radiat exposur acut high intens chronic lower dose level nation aeronaut space administr nasa identifi requir discov develop radioprotector mitig protect astronaut space mission sustain partnership sister agenc three organ must continu leverag fund find overlap research area acceler biomark identif product develop help safeguard differ yet undeni similar human popul cancer patient public citizen astronaut
D000078642;D011832;D013026
T061;T047;T037;T057
36,336,374
high throughput screen strategi space base radiat countermeasur discoveri human begin ventur space approach better protect astronaut hazard found space need develop one particular hazard concern complex radiat ever present deep space current unlik enough spacecraft shield could launch would provid adequ protect astronaut long durat mission journey mar back effort identifi mean protect prophylact radioprotect drug propos potenti mean reduc biolog damag caus radiat unfortun radioprotector approv fda usag develop protect normal cellstissu acut high level radiat exposur oncolog radiat treatment date essenti radioprotector develop specif counteract effect chronic low dose rate space radiat review highlight high throughput screen hts methodolog could implement identifi radioprotect agent sever potenti target pathway phenotyp assay discuss along potenti challeng toward screen radioprotector util hts strategi one propos potenti identifi new chemic scaffold develop efficaci radioprotector specif design protect astronaut deep space journey overarch goal review elicit broader interest appli drug discoveri techniqu specif hts toward identif radiat countermeasur design efficaci toward biolog insult like encount astronaut long durat voyag
D003359;D013026;D011837
T121;T039;T070;T057
36,336,373
high throughput screen small molecul potenti countermeasur galact cosmic radiat induc cellular dysfunct space travel increas galact cosmic ray exposur flight crew signific elev travel move beyond low earth orbit includ combin high energi proton heavi ion fe distinct differ biolog respons low energi transfer x ray high energi transfer high let howev given relat low fluenc rate exposur flight oper might possibl manag deleteri effect use small molecul current avail virtual report date examin small molecul manag radiat exposur base low let challeng end fda approv drug librari drug use perform high throughput screen cultur cell follow exposur galact cosmic radiat hc myoblast es pluripot cell hy endotheli cell line expos singl exposur cgi use ion gcrsim protocol develop nasa space radiat laboratori nsrl follow gcr exposur cell maintain two week drug hierarch cumul score develop incorpor measur mitochondri cellular function oxid stress cell senesc top score retest follow similar protocol use drug within drug consid anti inflammatori capac other also indirect suppress pro inflammatori pathway note antioxid capac lead candid came differ drug class includ angiotensin convert enzym inhibitor antagonist cox inhibitor well drug mediat histamin receptor surpris differ class anti diabet medic observ use includ sulfonylurea metformin use hierarch decis structur identifi sever lead candid one drug even drug class complet success across paramet test suggest complex manag consequ galact cosmic radiat exposur
D003359;D013026;D020450
T196;T070;T057
36,336,372
rrx right stuff protect treatment outer space antibiot aspirin antimalari anticanc agent half world best sell drug deriv natur howev acceler climat disrupt habitat destruct pollut biodivers loss negat impact potenti natur sourc continu serv repositori novel pharmaceut basi final frontier drug develop perhap rainforest coral reef natur habitat rather aerospac industri virtual unlimit inexhaust man made librari potenti bioactiv compound first aerospac sourc therapeut reach clinic rrx inhibitor nod like receptor nucleotid bind oligomer domain leucin rich repeat pyrin domain nlrp inflammasom phase trial treatment small cell lung cancer sclc soon start phase trial protect chemoradiotherapi induc sever oral mucos first line head neck cancer man mission moon mar asteroid well space tourism beckon perhap fit compound like rrx deriv trinitroazetidin tnaz explos propel rocket potenti purpos option mitig major biomed effect space radiat exposur includ cancer develop tissu degener within mission mission articl highlight promis rrx attenu acut late effect radiat exposur astronaut includ develop cancer
D001384;D009369;D013026
T057;T191;T109
36,336,371
angiotensin convert enzym ace inhibitor radiat countermeasur long durat space flight angiotensin convert enzym ace inhibitor effect countermeasur chronic radiat injuri rodent model evid similar effect human rodent model ace inhibitor effect mitig radiat injuri kidney lung central nervous system cns skin even start week irradi human best data efficaci radiat countermeasur come retrospect studi injuri radiotherapi patient propos ace inhibitor dose approv human use indic could use reduc risk chronic radiat injuri deep space explor potenti interact ace inhibitor micrograv due effect ace inhibitor fluid balanc use might restrict post exposur whenif radiat exposur reach danger level major unresolv issu approach spars evid efficaci ace inhibitor low dose rate exposur andor high let radiat would occur long durat space flight second issu lack clear mechan action ace inhibitor mitig make obtain appropri label food drug administr anim rule difficult
D011832;D013026
T047;T037;T057
36,336,370
countermeasur develop space radiat induc gastrointestin carcinogenesi current futur perspect signific higher probabl space radiat induc gastrointestin gi cancer incid mortal mar mission project use biophys statist model approach may exceed current nasa mandat limit less reid risk exposur induc death sinc spacecraft shield fulli effect heavi ion space radiat unmet need develop effect medic countermeasur mcm strategi heavi ion space radiat induc gi carcinogenesi safeguard astronaut past success appli gi cancer mous model approach understand space radiat induc gi cancer risk associ molecular signal event also test sever potenti mcms safeguard astronaut prolong space mission review provid updat summari mcm test use gi cancer mous model approach lesson learn perspect senesc signal target approach desir protect space radiat induc gi carcinogenesi furthermor also discuss advanc senotherapeut candidatescombin potenti mcm space radiat induc gi carcinogenesi
D003359;D013026;D009381
T070;T191;T057
36,336,369
countermeasur efficaci apigenin silicon ion induc earli damag blood bone marrow expos cblj mice investig countermeasur efficaci apigenin ap given diet supplement radiat induc damag hematopoiet tissu collect day total bodi exposur male cblj mice gy mevn silicon si ion gave food ap concentr mgkg bodi weight bw ap without ap ap mice irradi four group mice six mice group control ie radiat gy ap group radiat gy ap group radiat gy ap group radiat gy ap complet blood count cbc differenti blood count perform mous mous anti clastogen activ ap evalu use vivo blood erythrocyt micronucleus mn assay mous bone marrow bm cell collect use measur level activ nuclear factor kappa b nf b pro inflammatori cytokin ie tumor necrot factor alpha tnf interleukin il il beta il il use coloni form unit assay cfu tool studi countermeasur efficaci ap harm effect si ion prolifer hematopoiet stemprogenitor cell hspcs result show ap high effect prevent leukopenia thrombocytopenia also enhanc erythropoiesi prolifer hspcs also observ potent anti clastogen activ ap given mice diet supplement found ap effect suppress activ nf b pro inflammatori cytokin suggest ap given diet supplement protect mice si ion induc damag hematopoiet tissu irradi male cblj mice via anti inflamm activ
D001853;D047310
T121;T023;T024;T109
36,336,368
need biolog countermeasur mitig risk space radiat induc carcinogenesi cardiovascular diseas central nervous system defici nasa current plan long durat deep space explor mission outsid low earth orbit leo result exposur astronaut relat high lifetim dose ioniz radiat ir exceed human previous encount space concern exposur long term health consequ radiat carcinogenesi cardiovascular degen diseas central nervous system decrement exist engin solut insuffici decreas lifetim accumul ir exposur level current allow agenc standard therefor appropri countermeasur mitig strategi must develop enabl long durat mission emerg discoveri field radiat oncolog mitig acut radiat syndrom ar demonstr potenti compound basedbiolog radiomodifi drastic improv clinic outcom repres promis strategi space radiat countermeasur develop review outlin uniqu challeng pose space radiat environ defin limit terrestri radiat protect strategi space describ brief overview current space radiat countermeasur develop strategi highlight potenti new approach countermeasur identif develop specul potenti benefit beyond space explor
D002318;D013026;D003359
T047;T070;T057
36,336,367
medic countermeasur hematopoiet subsyndrom acut radiat syndrom space year apollo mission end nation aeronaut space administr nasa intern space agenc prepar return moon step toward deep space explor dose rang fraction gray gy gy crew risk develop bone marrow failur associ hematopoiet subsyndrom acut radiat syndrom h ar requir pharmacolog intervent reduc risk life mission complet four medic countermeasur mcm coloni stimul factor class drug approv treatment myelosuppress associ ar taken conjunct antibiot fluid antidiarrh antiemet antipyret treatment symptomat ill likelihood recoveri mission complet great improv current review describ perform health risk deep space flight ioniz radiat exposur crew mission moon mar us food drug administr fda approv medic intervent treat ar expans human explor mission beyond low earth orbit leo includ near term lunar futur mar mission inclus mcms counteract ar spaceflight kit critic preserv crew health perform
D054508;D000078642;D011835;D013026
T061;T037;T057
36,336,366
acceler space radiat countermeasur develop drug repurpos discoveri safe effect radiat countermeasur mcm long durat spaceflight challeng due complex space radiat biolog high safeti requir clinic valid molecular target use case preclin model sever known limit challeng make evalu exist fda approv drug indic drug repurpos attract strategi acceler space radiat countermeasur develop drug repurpos offer sever advantag de novo drug discoveri includ establish manufactur method human clinic safeti data well understood dose pharmacokinet consider limit work fix set possibl candid compound properti repurpos drug tailor well defin new indic reformul develop drug combin drug repurpos thus attract strategi mitig high risk cost drug develop deliv new countermeasur protect human space radiat long term mission
D058492;D013026
T062;T057;T061
36,336,365
arm forc radiobiolog research instituteuniform servic univers health scienc perspect space radiat countermeasur discoveri need develop deploy medic countermeasur mcms order support astronaut space mission excess exposur ioniz radiat exposur radiat environ extraterrestri space complex character near constant fluenc element atom particl proton domin particl type wide differ energi ionize potenti chronic exposur ioniz radiat carri near long term health risk general relat relat intens durat exposur radiat associ health risk manag limit extent physic mean perhap might effect manag biomed arm forc radiobiolog research instituteuniform servic univers health scienc long histori research develop mcms specif design support terrestri base militari mission involv radiat threat compon develop mcms low high dose radiat major aim current research provid lesson learn develop countermeasur applic futur space mission extraterrestri radiat environ
D003359;D013026;D008889
T070;T097;T057
36,336,364
microglia rheostat space radiat effect cns microenviron microglia innat immun cell within brain aris distinct myeloid lineag like tissu resid macrophag microglia respond injuri immun challeng particip repar process phagocytosi preserv normal function import also particip normal homeostat process includ mainten neurogen nich synapt plastic associ develop review highlight aspect microgli biolog repeat insult occur age neurodegen diseas possibl radiat exposur may heighten microgli respons contribut dysfunct creat situat normal repar mechan longer suffici maintain brain health idea discuss context evolv literatur focus microgli respons possibl target mitig late cns radiat effect repres potenti risk futur explor deep space environ
D019636;D011832
T047;T037
36,336,363
target hippocamp neurogenesi protect astronaut cognit mood declin due space radiat effect neurogenesi essenti lifelong process neural stem cell generat new neuron within hippocampus center learn memori mood control neural stem cell vulner environment insult span chronic stress radiat insult reduc number diminish neurogenesi lead memori declin anxieti depress preserv neural stem cell could thus help prevent neurogenesi associ patholog outcom particular import long term space mission environment exposur radiat signific higher earth multipl develop mechanist discoveri radiat injuri hippocamp neurogenesi new platform develop select specif effect safe small molecul neurogenesi protect agent hold great promis minim radiat damag neurogenesi review summar effect space like radiat hippocamp neurogenesi focus current advanc drug discoveri develop discuss nuclear receptor tlxnre oleic acid receptor exampl neurogen target might rescu neurogenesi follow radiat
D018480;D011832
T047;T037;T097
36,336,362
compact portabl sourc high let radiat valid potenti applic galact cosmic radiat countermeasur discoveri implement systemat program galact cosmic radiat gcr countermeasur discoveri requir conveni access ground base space radiat analog current gold standard approach gcr simul use particl acceler sequenti irradi ion beam repres differ gcr compon limit particular studi non acut respons strategi requir robot instrument implement complex vitro model emerg altern anim experiment explor theoret practic issu relat differ approach provid high let radiat field space radiat countermeasur discoveri base use compact portabl sourc generat neutron induc charg particl present model studi show dd dt neutron generat well amb radionuclid base sourc generat charg particl linear energi transfer let distribut within rang biolog interest extend kevm resembl let distribut refer gcr radiat field experienc spacecraft lunar surfac also demonstr feasibl use dd neutron induc bp dna doubl strand break repair foci hbec kt line human bronchial epitheli cell wide use studi lung carcinogenesi neutron induc foci larger persist x ray induc foci consist induct complex difficult repair dna damag characterist exposur high let kevm radiat discuss limit neutron approach includ low fluenc low let rang kevm absenc certain long rang featur high charg energi particl track present concept integr compact portabl sourc multiplex microfluid vitro cultur system discuss pathway valid use compact portabl sourc countermeasur discoveri
D003359
T070
36,336,361
consider carcinogenesi countermeasur develop use mous model activ space expos human profound new environ challeng human perform requir innov support technolog among environment variabl exposur ioniz radiat major concern astronaut long term effect exposur divers tissu poor understood need howev creat opportun novel approach particular develop countermeasur effect ioniz radiat exposur carcinogenesi present uniqu challeng diseas process due inher complex process challeng obtain larg volum clinic evid thus develop countermeasur address potenti effect ioniz radiat exposur requir understand biolog underpin design countermeasur effect conjunct high robust model approach test examin vivo review highlight specif consider acceler develop space radiat countermeasur carcinogenesi
D000069079;D013026
T037;T057
36,336,360
small tissu chip big opportun space medicin spaceflight environ includ micrograv radiat may consider effect health perform astronaut especi long durat martian mission convent ground space experiment approach employ investig comprehens biolog effect spaceflight environ class recent emerg bioengin vitro model tissu chip character small footprint potenti autom recapitul tissu level physiolog thus promis help provid molecular cellular insight space medicin briefli review technic advantag tissu chip discuss specif chip physiolog recapitul sever tissu chip launch space pois come multi agenc collabor impli increas import role tissu chip space medicin
D000337;D018535;D013026;D014893
T083;T070;T091;T057
36,336,359
clinic trial dish space radiat countermeasur discoveri nasa aim return human moon within next five year land human mar decad space radiat exposur repres major challeng astronaut health long durat mission link increas risk cancer cardiovascular dysfunct central nervous system cns impair negat outcom character radiat health effect develop correspond countermeasur high prioriti prepar long durat space travel due limit anim cell model develop novel physiolog relev radiat model need better predict individu risk bridg gap preclin test clinic trial drug develop clinic trial dish ctid possibl use human induc pluripot stem cell hipsc offer power tool drug safeti efficaci test use patient specif cell model review develop applic ctid space radiat biolog countermeasur studi focus progress made past decad
D003359;D057026;D013026;D011832
T070;T025;T037;T047;T057
36,336,358
revers radiat induc immunosuppress use new therapeut modal radiat induc immun suppress pose signific health challeng million patient undergo cancer chemotherapi radiotherapi treatment astronaut space tourist travel outer space limit number recombin protein therapi sargramostim approv acceler hematolog recoveri pronounc role granulocyt macrophag coloni stimul factor gm csf csf proinflammatori cytokin pose addit challeng creat immun dysfunct toward pathogen autoimmun diseas present approach high throughput drug discoveri target valid lead molecul identif use nucleic acid base molecul nanoligom molecul ration design use bioinformat artifici intellig ai base rank method synthes singl modal combin differ design element downregul gene express target gene result elev diminish protein express intend target method addit alter relat gene network target ultim result pathway modul approach use perturb identifi effect upstream regul canon pathway therapeut intervent revers radiat induc immunosuppress lead nanoligom identifi screen human donor deriv peripher blood mononuclear cell pbmcs upregul erythropoietin epo show greatest revers radiat induc cytokin chang test vivo mous radiat model low dose mgkg intraperiton administr shown regul gene express epo lung tissu well counter immun suppress result point broader applic approach toward drug discoveri potenti investig lead molecul revers gene therapi treat advers health outcom induc radiat exposur
D007963;D001185
T090;T025;T066;T073
36,336,357
har nucleic acid technolog human health earth space nucleic acid therapeut versatil class sequenc programm drug offer robust clinic viabl strategi modul express correct genet defect contribut diseas major drug current market target protein howev protein repres subset possibl diseas target nucleic acid therapeut allow intuit engag genom sequenc provid direct way target mani diseas genet root caus clinic success depend platform technolog support durabl well toler pharmacolog activ given tissu nucleic acid drug possess potent combin target specif adapt requir advanc drug develop mani diseas therapeut technolog matur clinic applic also expand access person therapi patient rare solo genet diseas spaceflight crew member expos uniqu hazard spaceflight especi relat galact cosmic radiat gcr exposur repres anoth patient subset may also benefit nucleic acid drug countermeasur review discuss various class rna dna target nucleic acid drug provid overview present day clinic applic describ major strategi improv deliveri safeti overal efficaci
D009696
T123;T114
36,336,356
look horizon potenti uniqu approach develop radiat countermeasur deep space travel futur lunar mission beyond requir new innov approach radiat countermeasur translat research institut space health trish focus identifi support uniqu approach reduc risk human health perform futur mission beyond low earth orbit paper describ three fund complementari avenu reduc risk human radiat exposur experienc deep space first focus identifi new therapeut target reduc damag effect radiat focus high throughput genet screen access sometim call lower organ model second focus design innov approach countermeasur develop special attent nucleotid base methodolog may constitut agil way design therapeut final focus develop new innov way test radiat countermeasur human model system anim studi continu benefici studi space radiat imperfect translat human use three dimension complex vitro model promis approach aid develop new countermeasur person assess radiat risk three distinct uniqu approach complement tradit space radiat effort provid futur space explor option safeguard short long term health
D003359;D011835;D013026;D000069079
T061;T070;T037;T057
36,336,355
break limit biolog countermeasur space radiat exposur enabl long durat spaceflight concern health effect space radiat exposur current limit durat deep space travel effect biolog countermeasur could allow human break limit facilit human explor sustain presenc moon mar elsewher solar system issu present collect articl provid perspect data relev implement countermeasur discoveri develop program topic includ agenc drug develop perspect prospect repurpos exist drug agent potenti adopt new technolog high throughput screen novel anim microphysiolog model altern ground base radiat sourc long term goal countermeasur program includ reduct risk radiat exposur induc cancer death accept level reduct risk brain cardiovascular system organ
D013026;D000069079
T037;T057
36,335,989
overview fuzuloparib treatment ovarian cancer background futur perspect last decad clinic trial use various poli adp ribos polymeras parp inhibitor patient ovarian cancer shown promis result introduct parp inhibitor chang treatment landscap improv outcom patient ovarian cancer fuzuloparib develop jiangsu hengrui pharmaceut co ltd novel oral avail small molecul parp inhibitor introduc trifluoromethyl group chemic structur fuzuloparib exhibit higher stabil lower inter individu variabl parp inhibitor sever clinic trial fzocus seri other carri assess efficaci safeti fuzuloparib differ line treatment advanc recurr ovarian cancer treatment mainten present recent data studi discuss current progress potenti futur direct
D000067856;D010051
T121;T191
36,335,987
lncrna xist promot carboplatin resist ovarian cancer activ autophagi via target mir pfoxp axi resist chemotherapi drug make ovarian cancer oc difficult treat ultim kill patient long non code rnas close relat carboplatin resist oc present studi explor role lncrna x inact specif transcript xist carboplatin resist oc
D062085;D035683;D010051
T123;T191;T114
36,335,970
helicobact pylori erad primari prevent peptic ulcer bleed older patient prescrib aspirin primari care heat randomis doubl blind placebo control trial peptic ulcer patient receiv aspirin associ helicobact pylori infect aim investig whether h pylori erad would protect aspirin associ ulcer bleed
D016480;D016481;D016998;D010437
T047;T007
36,335,797
random control trial virtual realiti learn environ obstetr medic student teach virtual realiti learn environ vrle potenti transform deliveri teach obstetr medic student often find difficult conceptu fetal lie present
D013337;D000076142;D004501
T065;T066;T097
36,335,486
ki adn vesjt ki nem live donor transplant frequent medic intervent beyond medic issu live organ donat rais psychosoci question donor motiv
D009927
T033;T055;T058;T073
36,335,485
diabet mellitus kapcsolata depressziv szorongss az letminsggel mani studi demonstr psycholog factor play import role develop cours diabet mellitus
D011788;D003924
T078;T047
36,335,484
kontrasztanyag nlkli mgnesesrezonancia angiogrfia diagnosztikus teljestmny al vgtagi verrbetegekben lower extrem arteri diseas lead often associ chronic renal failur use nephroprotect modal essenti
D058729
T047
36,335,483
silver russel szindrma diagnosztikai lpsei terpi lehetsgei egi csaldi halmozdst mutat eset kapcsn character intrauterin postnat growth retard consequ small statur silver russel syndrom associ typic minor anomali relat macrocephalia protrud forehead downturn corner mouth micrognathia low set ear facial skelet limb asymmetri find involv main endocrin system molecular background syndrom complex often caus involv critic region chromosom andor chromosom besid molecular diagnosi netchin harbison clinic score system aim contribut success diagnosi silver russel syndrom although silver russel syndrom most sporad case report present extrem rare famili accumul three four sibl affect silver russel syndrom earli diagnosi import initi adequ feed nutrit guidanc enhanc earli develop start growth hormon therapi soon possibl would like emphas manag long term follow crucial prevent potenti complic treat specif issu appropri orv hetil
D056730
T047
36,329,792
detect mec gene methicillin resist staphylococcus aureus mrsa isol milk risk factor farm probolinggo indonesia background staphylococcus aureus common found dairi cow sourc contamin milk aureus resist beta lactam antibiot especi cefoxitin refer methicillin resist staphylococcus aureus mrsa spread mrsa separ sanit manag milk origin milk collect udder hand farmer milk process purpos studi examin level mrsa contamin dairi cow milk farmer hand method total sampl dairi cow milk sampl farmer hand swab collect dairi farm probolinggo east java indonesia sampl cultur purifi use mannitol salt agar msa profil aureus resist establish disk diffus test use disk beta lactam antibiot name oxacillin cefoxitin result aureus isol resist oxacillin cefoxitin antibiot test oxacillin resist screen agar base orsab confirm test mrsa ident aureus isol suspect mrsa test genotyp polymeras chain reaction pcr method detect presenc mec gene result isol identif found isol aureus result resist test found isol aureus resist oxacillin isol resist cefoxitin orsab test found mani isol posit mrsa pcr test detect presenc mec gene three isol posit mec gene conclus studi show sever aureus isol mrsa gene encod mec dairi farm
D055624
T007
36,329,791
return work school covid pandem stress schoolteach assess immedi psycholog effect cross section studi background adopt remot class student vogu sinc onset pandem school reopen phase manner second wave coronavirus diseas covid india revert regular face face teach student becam challeng teacher student especi time impend third wave way studi aim assess presenc symptom depress anxieti stress teacher attend reopen school scenario face face class addit studi associ psycholog symptom teacher age group gender school board school institut type method cross section studi conduct octob decemb school reopen data collect use googl form questionnair schoolteach depress anxieti stress scale item dass questionnair assess psycholog symptom result schoolteach femal privat institut central board secondari educ cbse school board preval depress anxieti stress teacher respect near femal teacher express depress anxieti stress symptom amongst age group symptom higher group found anxieti statist signific compar gender p found statist signific differ concern age group school board school institut psycholog symptom conclus preval psycholog symptom high among schoolteach school reopen regular face face teach gender associ anxieti teacher agre identifi teacher symptom provid adequ psycholog counselingsupport would improv mental health status therebi qualiti teach student
D058873;D000086382
T047;T067
36,250,003
genet environment perturb alter rhythmic express pattern circadian long non code rna pera mous liver background long non code rnas lncrnas play wide varieti biolog role without encod protein although function mani lncrnas uncov recent year regulatori mechan lncrna express still poor understood despit express pattern lncrnas much specif compar mrnas investig rhythmic express pera novel lncrna regul circadian rhythm given pera express antiphas period per core circadian clock gene transcrib antisens strand per hypothes rhythmic pera express driven either promot rhythmic per transcript via transcript interfer method leverag exist circadian rna seq dataset analyz express pattern pera per respons genet environment disrupt circadian rhythm mous liver test hypothes compar chang express pattern pera per conclus found case pera express independ control circadian transcript factor case pattern express chang consist transcript interfer independ regul hypothes although addit experi necessari distinguish possibl find work contribut deeper understand mechan express lncrna regul
D062085;D057906
T123;T040;T114
35,999,844
case report caecal volvulus manag diagnosi treatment young patient caecal volvulus cv rare caus intestin obstruct defin axial torsion caecum ascend colon termin ileum around mesenter vascular pedicl lead ischemia bowel necrosi year old woman signific medic histori admit general abdomin pain evolv three day along constip abdomin distens vomit physic examin show general abdomin tender rigid rebound tender associ abdomin distens tympan upon percuss laboratori find within normal limit abdomin comput tomographi scan reveal distens loop larg bowel long axi extend right lower quadrant epigastrium left upper quadrant colon haustral pattern absent abdomin comput tomographi scan show round focal collect air distend bowel haustral creas upper left quadrant addit spiral loop collaps cecum give whirl sign note along low attenu fatti mesenteri twist bowel patient underw emerg laparotomi caecectomi use gea charg patient complaint post oper cv rare caus bowel obstruct main caus exceed mobil caecum despit rare cv repres second common caus larg bowel volvulus behind sigmoid volvulus acut obstruct cv hard differenti clinic obstruct small bowel therefor radiolog exam need surgeri gold standard treatment cv report rare case cv highlight rariti patholog specifi diagnost therapeut mean clinic biolog evolut
D045822;D002429;D007415
T047
35,923,292
tourett syndrom research highlight summar select research report relev tourett syndrom author consid import interest author welcom articl suggest thought feedback reader
D005879
T047
36,335,463
irx amelior sepsi induc acut kidney injuri mice promot cxcl sepsi induc acut kidney injuri general critic complic high relev kidney inflamm spite advanc clinic critic care specif effect therapi acut kidney injuri still insuffici present studi aim investig protect effect iroquoi homeobox gene irx sepsi induc kidney dysfunct mice
D058186;D018805
T047;T046;T037
36,335,462
dimethyl itacon inhibit lps induc inflammatori releas apoptosi alveolar type ii epitheli bronchial epitheli cell activ pulmonari surfact protein injuri lung common clinic serious inflammatori diseas howev pathogenesi remain unclear exist treatment includ cytokin therapi stem cell therapi hormon therapi complet effect treat diseas dimethyl itacon dmi surfact import anti inflammatori effect
D011663;D055370
T123;T121;T109;T037;T047
36,335,461
knockdown dapk attenu il induc extracellular matrix degrad inflammatori respons osteoarthr chondrocyt via regul p mapk signal pathway reveal possibl effect death associ protein kinas dapk progress osteoarthr oa potenti under mechan
D010003;D035683
T123;T047;T114
36,335,460
analysi respons sever eosinophil asthmat patient benralizumab clinic trial real life studi publish show effect benralizumab sever eosinophil asthmat patient aim present studi describ super respond benralizumab seri patient complet least year treatment compar super respond non super respond
D018927;D001249;D011657;D009298
T033;T121;T047
36,335,459
orientin inhibit progress fibroblast like synovi cell rheumatoid arthriti regul mapk signal pathway natur compound found play essenti role divers inflammatori diseas includ rheumatoid arthriti ra orientin flavonoid compound close relat divers patholog process nevertheless role orientin ra still unknown
D000070918;D001172
T047;T025
36,335,458
urolithin induc protect autophagi allevi inflamm oxid stress endoplasm reticulum stress pediatr pneumonia investig therapeut effect urolithin ua pediatr pneumonia under mechan
D059865;D011014
T049;T047;T050
36,335,457
therapeut potenti caffein polycyst ovari syndrom rat model via modul proinflammatori cytokin antioxid activ recent studi shown polycyst ovari syndrom pcos affect women worldwid associ reproduct metabol dysfunct caffein natur found tea cocoa coffe shown caffein chang hormon profil stimul ovul enhanc fertil therefor studi effect caffein rat pcos investig purpos femal rat divid five group control group without intervent sham group administr oliv oil caffein solvent pcos group inject mg estradiol valer rat caffein group administr mgkg caffein rat pcos caffein group day treatment ovari rat remov prepar evalu includ hematoxylin eosin stain tunel assay real time pcr biochem analysi administr caffein pcos mice consider reduc volum ovari p follicular cluster p howev superoxid dismutas glutathion peroxidas dramat activ pcos caffein group compar other p besid caffein treatment pcos mice led bax reduct increas bcl express hand express il tnf pcos caffein group high compar group found caffein reduc apoptosi inflamm pcos ovari enhanc unpleas symptom pcos
D011085
T047
36,335,456
studi specif gut microbiota adult patient delay onset atop dermat atop dermat ad common recurr skin diseas first onset ad adult known adult onset atop dermat aoad gut microbiota close associ ad gut skin axi consid novel target prevent ad howev studi analyz aoad particular studi compar differ intestin flora aoad persist ad patient
D003876;D000069196
T047;T007;T001
36,335,455
new classif option nsaid hypersensit kalyoncu classif european network drug allergi enda propos consensus document hypersensit reaction nonsteroid anti inflammatori drug nsaid subgroup patient nsaid exacerb respiratori diseas nerd develop urticariaangioedema type reaction respons nsaid kalyoncu classif might novel option classifi patient nsaid hypersensit nh studi compar enda kalyoncu classif
D004342;D000707;D000799;D012220;D014581
T047;T046
36,335,454
knockdown bcl allevi psoriasi dyslipidemia comorbid regul akt pathway psoriasi consid inflammatori skin diseas accompani dyslipidemia comorbid b cell leukemia bcl belong ib inhibitor nuclear factor kappa b nf b famili regul inflammatori respons associ nf b role bcl psoriasi investig studi
D011565;D050171;D015448
T047;T046;T191
36,335,453
anethol amelior inflamm induc monosodium urat acut gouti arthriti model via inhibit tlrsmyd pathway assess effect anethol monosodium urat msu induc inflammatori respons investig role acut gouti arthriti aga verifi molecular mechan
D015210
T047
36,335,452
asthma chronic obstruct pulmonari diseas overlap syndrom aco exist narrat review epidemiolog practic asthma chronic obstruct pulmonari diseas copd tradit approach separ entiti must research treat separ grow recognit howev substanti proport patient obstruct lung diseas characterist asthma copd term asthma copd overlap syndrom aco lung diseas expert difficulti defin aco mani still resist accept possibl asthma copd may link like practic clinician may equal confus identifi treat aco narrat review aim clarifi concept aco definit argu best way understand aco view chronic lung diseas process longitudin rather cross section present evid aco end result natur histori sever asthma review also point serious gap knowledg regard therapi aco present emerg data support intracellular respiratori pathogen chlamydia pneumonia possibl common etiolog agent sever asthma aco
D000080445;D029424;D001249
T047
36,335,451
morronisid allevi lipopolysaccharid induc inflammatori oxid stress inflammatori bowel diseas inhibit nlrp nf b signal pathway investig effect morronisid inflammatori oxid stress lipopolysaccharid lps induc inflammatori bowel diseas ibd cell model
D008070;D015212
T047;T109
36,335,450
protopin allevi lipopolysaccharid trigger intestin epitheli cell injuri retard nlrp nf b signal pathway reduc inflamm oxid stress inflammatori bowel diseas ibd common chronic intestin diseas protopin isol differ plant investig understand special function vari diseas howev regulatori effect protopin progress ibd remain unclear studi aim explor effect protopin progress ibd under regulatori mechan action
D016328;D015212
T129;T047;T116
36,335,449
research progress statin immun regul multipl sclerosi experiment allerg encephalomyel aim studi summar studi statin use treat multipl sclerosi ms experiment allerg encephalomyel eae under mechan
D004681;D009103;D019161
T121;T047;T050;T109
36,335,448
anti inflammatori effect n trifluoromethylphenyl cyano hydroxi croton acid amid glucon acid allerg rhiniti asthma control allerg rhiniti asthma main airway diseas higher preval eosinophil inflamm airway hyperrespons mucus hypersecret revers airflow obstruct immunopathogenesi symptom rhiniti asthma croton acid bio activ inflamm glucon acid chelat may protect croton acid activ airway togeth may control allerg rhiniti asthmaallerg rhiniti asthma mice model treat croton glucon acid total ige histamin il il il level measur lung tissu goblet cell hyperplasia mucus hypersecret inflamm evaluatedth level il goblet cell hyperplasia perivascular peribronchi inflamm control croton acid asthma allerg rhiniti group total ige hista mine il il level mucus hypersecret signific chang treat nontreat asthma rhiniti group
D012220;D001249;D065631
T047
36,335,447
contact dermat black henna tattoo child due paraphenylenediamin temporari henna tattoo becom increas popular particular among children teenag word henna persian origin prepar plant lawsonia inermi belong famili lythracea concern allerg reaction natur henna past rare respons contact dermat frequent paraphenylenediamin ppd ad past author present case femal child erythemat exanthem appear applic black henna tattoo diagnosi contact dermat black henna tattoo hypothesis epicutan test perform immunoalergolog depart coimbra univers hospit use standard european batteri natur henna past test reveal posit reaction ppd
D013653;D017449
T033;T058;T047
36,335,446
serum dual specif phosphatas reflect decreas exacerb risk correl less advanc exacerb sever lower inflammatori cytokin children asthma fact dual specif phosphatas dusp regul cell activ pro allerg respons inflamm engag pathogenesi asthma clinic role children asthma unclear present studi aim explor express dusp associ exacerb risk sever inflammatori cytokin children asthma
D016207;D001249
T129;T047;T116
36,335,445
ctrp suppress neutrophil extracellular trap format amelior sepsi induc lung injuri inactiv erk pathway septic lung injuri associ excess neutrophil activ neutrophil extracellular trap format contribut inflammatori lung injuri sepsi cqtumor necrosi factor relat protein ctrp paralog adiponectin exert anti inflammatori antioxid properti role ctrp sepsi associ inflammatori lung injuri investig studi
D065206;D055371;D018805
T026;T047;T046;T037
36,335,444
omalizumab allergen immunotherapi respiratori allergi mini review allergen immunotherapi committe italian societi pediatr allergi immunolog siaip although current approv treat sever asthma chronic spontan urticaria omalizumab also effect safe add treatment allerg diseas name omalizumab propos use add therapi patient allerg rhiniti asthma undergo specif allergen immunotherapi ait ait treatment modifi natur histori ige mediat diseas brief review summar avail evid controversi efficaci safeti omalizumab combin specif ait
D065631;D001249
T047
36,335,443
whole exom sequenc identifi homozyg novel rag mutat child omenn syndrom omenn syndrom os rare type sever combin immunodefici manifest erythroderma eosinophilia hepatosplenomegali lymph adenopathi elev level serum ige os inherit autosom recess mode inherit germlin mutat human rag gene caus os
D016511
T047
36,335,442
high throughput virtual screen strategi develop potenti treatment bronchial asthma target interleukin cytokin signal chronic inflamm airway passag lead clinic syndrom pediatr asthma allerg reaction caus bacteri viral fungal infect lead immun dis balanc prime helper cell th specif cluster differenti cd cell differenti favor th specif respons activ inter leukin interleukin il il cytokin signal activ secret immunoglobulin e ige il develop bronchial asthma elev bronchial hyperrespons enabl product immunoglobulin igm ige present studi aim target il signal use molecular dock understand molecular dynam simul mds propos compel candid treat asthma develop librari avail allerg drug n check bind affin il protein bpnpdb molecular dock confirm best pose bind energi epinephrin guaifenesin respect studi interact hydrogen bond van der wall estim electrostat energi suffici interact activ site il shown inhibit inflammatori signal comput result confirm epinephrin guaifenesin potenti ligand show potenti inhibitori activ il signal studi also suggest design new ligand screen larg cohort drug futur predict exact mechan control critic featur asthma
D006140;D001249;D006967
T121;T047;T046;T109
36,335,441
new autoimmun diseas atop dermat children atop dermat ad main consid allergi exacerb allerg factor evid suggest exist autoimmun compon pathophysiolog ill studi literatur dealt occurr autoimmun children ad analyz follow studi publish pubm year clinic sign symptom similar autoimmun diseas period remiss relaps correl ad autoimmun diseas describ patient ad also present wide rang autoimmun comorbid three major factor contribut pathogenesi ad damag skin barrier disord immun respons imbal skin microbiom base genet chang influenc environment factor predomin activ th cell increas th th th subset promot skin inflamm evid suggest ad might classifi autoimmun diseas allerg reaction
D003876;D001327;D006967
T047;T046
36,335,440
vitamin defici children adolesc food allergi associ number allergen sun exposur nutrit status object describ serum vitamin concentr children adolesc food allergi fa verifi associ number food allergen involv length sun exposur nutrit status cross section studi patient fa age year assess follow refer outpati clinic sao paulo brazil clinic biochem data collect analysi oh calcium phosphorus phosphatas parathyroid hormon pth high sensit c reactiv protein hs crp cut point use vitamin defici oh ngml vitamin defici detect patient median age year interquartil rang iqr median serum oh concentr ngml iqr multivari linear regress perform consid serum vitamin level depend variabl allergi multipl food invers length sun exposur direct nutrit status independ associ serum oh level p p respect patient cow milk allergi also show lower vitamin concentr comparison fa ngml iqr vs ngml iqr p vitamin defici affect half individu fa multipl food allergi associ lower vitamin concentr reinforc import monitor vitamin status patient fa
D014808;D016269
T047;T046
36,335,439
phlda knockdown inhibit inflamm oxid stress regul jnkerk pathway play protect role sepsi induc acut kidney injuri acut kidney injuri aki preval complic sepsi caus substanti burden patient famili well societi reliabl marker urgent requir prevent treatment aki pleckstrin homolog like domain famili member phlda implic various diseas involv sepsi induc aki remain explor jnkerk pathway reveal involv progress sepsi one previous studi demonstr phlda could activ jnkerk pathway hepat ischemiareperfus injuri nevertheless involv phlda sepsi trigger aki jnkerk pathway probe
D058186;D018805
T047;T046;T037
36,335,424
gynecomastia malign case male invas ductal breast carcinoma treat neoadjuv chemotherapi background male breast cancer repres rare malign identifi risk factor includ genet radiat exposur liver dysfunct concomit diagnosi klinefelt syndrom gynecomastia common present patient despit increas estrogen level adipos breast tissu gynecomastia proven signific risk factor carcinoma develop male patient new onset breast mass recommend undergo diagnost mammogram breast ultrasound evalu diagnos breast cancer common invas ductal carcinoma breast half patient found estrogen progesteron receptor erpr posit case report case report present black man gynecomastia areolar lesion month durat follow traumat event initi refer surgic team evalu subsequ imag biopsi data reveal erpr posit invas ductal carcinoma multidisciplinari discuss held patient arrang begin neoadjuv treatment doxorubicin hydrochlorid cyclophosphamid follow treatment paclitaxel ac chemotherapi follow bilater mastectomi adjuv hormon therapi conclus treatment male breast cancer remain relat like femal breast cancer may due limit data treatment male breast cancer thus far studi involv neoadjuv chemotherapi femal patient demonstr promis respons expand surgic option patient possibl decreas rate recurr addit studi warrant discern optim therapi male patient popul
D001943;D018567;D006177;D044584;D018270
T047;T191
36,335,423
octyl cyanoacryl hidden allergen common caus postsurg allerg contact dermat background octyl cyanoacryl topic adhes use wound closur becom common caus rash postsurg patient increas number case postsurg contact dermat attribut octyl cyanoacryl local skin reaction octyl cyanoacryl describ differ case report limit case report diffus cutan allerg reaction object aim studi review experi patch test cyanoacryl method report five case allerg contact dermat octyl cyanoacryl confirm patch test patient experienc skin reaction day surgeri patient describ erythemat prurit rash initi local incis subsequ spread surround area two five patient develop widespread rash requir longer durat system steroid octyl cyanoacryl remain agent low diagnost suspicion possibl caus contact dermat surgic procedur result patient one posit reaction octyl cyanoacryl pt four posit pt result one patient posit scratch test negat pt result test abrad skin increas yield conclus postsurg patient evalu use patch test clinic pictur suggest contact dermat
D014014;D017449;D005076
T184;T122;T047