PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,248,191 | inhibit mir p regul lipid metabol inflammatori cytokin secret macrophag allevi atherosclerosi improv tp express aim elucid regulatori function mir p lipid metabol inflammatori cytokin secret macrophag atherosclerosi | D050197;D035683 | T123;T047;T046;T114 |
36,248,190 | role noncod rna airway allerg diseas regul cell subset allerg rhiniti asthma common airway allerg diseas incid increas annual recent year human bodi frequent expos allergen environment irrit trigger immun inflammatori respons result alter gene express mount evid suggest epigenet alter strong associ progress sever allerg diseas noncod rnas ncrnas class transcrib rna molecul translat polypeptid consist three major categori microrna mirna long noncod rnas lncrnas circular rnas circrna previous studi show ncrnas involv physiopatholog mechan airway allerg diseas contribut occurr develop articl review current state understand role noncod rnas airway allerg diseas highlight limit recent studi outlin prospect research facilit clinic translat noncod rnas therapeut target biomark | D035683;D062085 | T123;T114 |
36,248,189 | influenc gut microbiota develop neurodegen diseas neurodegen disord mark neuron death time caus varieti cognit motor dysfunct protein misfold neuroinflamm mitochondri protein clearanc system dysfunct identifi common pathway lead neurodegener recent decad alter microbiom gut consid play central role diseas well health recent identifi anoth potenti featur seen neurodegen disord array microbi molecul releas digest tract may mediat gut brain connect permeat mani organ system includ nervous system furthermor recent find clinic well preclin trial suggest microbiota gut play critic part gut brain interplay misbal composit gut microbiom may link etiolog neurolog disord major neurodegen health problem under mechan still unknown review aim consid associ microbiota gut neurodegen disord well add understand signific gut microbiom neurodegener mechan underli know mechan behind gut microbiom role abund provid us new insight could lead novel therapeut strategi | D000069196;D064307;D019636 | T032;T007;T028;T047;T001 |
36,248,188 | lysophosphatid acid induc apoptosi dna damag oxid stress spinal cord neuron upregul lpalpa receptor lysophosphatid acid lpa disrupt effect lumbar spinal stenosi lss recent lpa report involv spinal cord neuron injuri toxic promot pathogenesi lss howev exact effect lpa spinal cord neuron remain unknown purpos studi investig effect lpa spinal cord neuron cytotox apoptosi dna damag oxid stress clinic detect lpa secret spinal cord neuron treat lpa cell viabil analyz mtt assay ldh leakag detect ldh kit cell apoptosi detect flow cytometri ros product measur dcfda stain mitosox red stain activ g g signal pathway detect serum respons factor respons element srf luciferas report gene relationship among lpa lpa rock examin western blot spinal cord neuron treat lpa cellular activ decreas ldh releas increas rho kinas inhibitor attenu lpa induc apoptosi dna damag oxid stress spinal cord neuron moreov mechanist investig indic lpa activ g rho rock induc apoptosi dna damag oxid stress spinal cord neuron upregul lpalpa receptor rho kinas inhibitor attenu effect lpa downregul lpalpa receptor taken togeth possibl mechan lpa secret lss patient aggrav patient injuri elucid use lpa induc spinal cord neuron injuri cell model vitro | D049368;D013119 | T116;T037;T192 |
36,248,187 | inhibit cebpb attenu lupus nephriti via regul pim signal system lupus erythematosus sle autoimmun diseas lead inflammatori damag multipl target organ lupus nephriti ln one life threaten organ manifest ccaatenhanc bind protein cebpb regul nlrp inflammasom involv pathogenesi sle howev role mechan cebpb ln remain unclear mrllpr mice lipopolysaccharid lps combin adenosin triphosph atp treat glomerular podocyt use model ln vivo vitro respect vivo investig express cebpb develop mrllpr mice assess effect cebpb inhibit renal structur function inject sh cebpb lentivirus mrllpr mice vitro glomerular podocyt treat pim oe si cebpb explor relat cebpb pim progress ln mice associ increas level cebpb inhibit cebpb amelior renal structur impair improv renal function damag associ ln knockdown cebpb could suppress activ nlrp inflammasom secret il il furthermor knockdown cebpb could inhibit nlrp inflammasom activ pyroptosi via bind pim promot downregul express overexpress pim revers effect cebpb defici regul cebpb pim facilit pyroptosi activ nlrp inflammasom therebi promot develop ln | D008180;D008181 | T047 |
36,247,882 | metabol activ recoveri intestin microbiota patient bronchial asthma establish high biolog divers intestin microorgan promot need scfas product induc immun regulatori pathway contribut anti inflammatori respons studi group patient allerg bronchial asthma ba investig studi patient test presenc sibo scfa spectrum determin sibo treatment patient studi group prescrib rifaximinum mg dose time day week patient prescrib rifaximinum dose follow administr lactobal probiot capsul time day month month probiot cours assign remain patient without sibo part ba complex therapi scfa studi immedi carri patient month probiot therapi cours | D001249;D000069196 | T047;T007;T001 |
36,247,876 | taz regul cisplatin resist epitheli ovarian cancer cell via angptlsox axi epitheli ovarian cancer eoc fatal gynecolog malign studi explor mechan taz regul drug sensit cisplatin ddp resist eoc cell angptlsox axi | D000970;D010051 | T121;T191;T109 |
36,247,875 | comprehens analysi role slca prognosi immun infiltr head neck squamous cell carcinoma slca upregul various cancer type promot prolifer invas metabol howev role prognosi immun regul head neck squamous cell carcinoma hnscc still obscur studi aim explor prognost immunotherapeut potenti slca hnscc | D015972;D006258 | T045;T191 |
36,247,874 | chemoprevent nqo induc mous tongu carcinogenesi akt inhibitor mmp rhoc signal pathway autophagi oral cancer oc common cancer head neck poor prognosi histopatholog follow stepwis pattern hyperplasia dysplasia cancer block progress oc precanc stage could great improv surviv cure rate akt protein play critic role signal transduct cancer cell found akt overexpress human oc sampl analysi tcga databas therefor studi aim investig chemoprevent effect akt inhibitor mk hcl oc vivo establish nitroquinolin oxid nqo induc mous tongu carcinogenesi model investig potenti chemoprevent effect mk hcl mous oc result nqo result show mk hcl could signific reduc incid rate growth oc inhibit transform dysplasia cancer nqo induc mous tongu carcinogenesi model simultan mark suppress cell prolifer angiogenesi mast cell mc infiltr nqo induc mous tongu cancer vitro result reveal mk hcl could also inhibit oral squamous cell carcinoma oscc cell malign biolog behavior includ cell prolifer coloni format cell invas migrat promot apoptosi mechanist studi reveal mk hcl suppress matrix metalloproteinas mmp rhoc express promot autophagi gene lc ii express summari find demonstr chemoprevent effect mk hcl nqo induc mous tongu carcinogenesi model like under mechan mediat mmp rhoc signal pathway autophagi | D002294;D009062 | T191 |
36,247,873 | tetrandrin attenu podocyt injuri inhibit trpc mediat rhoarock pathway tetrandrin tet compound found tradit chines medicin present protect effect kidney function studi aim clarifi efficaci under mechan tet podocyt injuri studi podocyt injuri induc rat adriamycin adr mpc podocyt construct trpc overexpress found tet treatment reduc level proteinuria serum creatinin blood urea nitrogen increas plasma albumin level adr induc rat tet reduc intracellular ca influx apoptosi mpc podocyt overexpress trpc tet downregul express renal trpc rhoa rock upregul express synaptopodin meanwhil reduc calcineurin activ vivo vitro conclus tet protect podocyt affect trpc downstream rhoarock signal pathway | D050199 | T025 |
36,247,866 | studi relationship correl turnov tendenc emerg nurs staff social work factor relationship correl emerg nurs staff turnov intent social work factor explor total nurs emerg depart hospit februari octob select research subject questionnair survey conduct among nurs compar general inform emerg nurs score turnov tendenc social support workplac violenc job burnout scale emerg nurs calcul multifactor logist regress use analyz influenc factor turnov tendenc emerg nurs staff spearman correl coeffici use analyz correl turnov tendenc emerg nurs staff influenc factor result survey show age educ level social support workplac violenc job burnout affect turnov tendenc emerg nurs staff manag pay attent take reason measur avoid staff turnov | D002055;D016529;D009741 | T091;T097;T048 |
36,247,865 | investig correl cuff inflat hypertens differ interarm diastol pressur induc singl arm ischemia correl cuff inflat hypertens differ interarm diastol pressur induc singl arm ischemia investig total patient undergo coronari angiographi hospit januari januari select divid non pseudohypertens non pht group case pht group case accord differ systol blood pressur diastol blood pressur measur direct indirect patient subject beam arm ischemia test blood pressur measur diastol pressur differ patient beam arm analyz endotheli function imag indic compar risk factor pht analyz binari logist regress diagnost efficaci diastol blood pressur differ interarm dbpi r pht patient analyz receiv oper characterist roc curv experiment result show diastol pressur differ induc singl arm ischemia use diagnosi cuff inflat hypertens | D006973 | T047 |
36,247,864 | studi huangqi bazhen decoct reliev chemotherapi intestin mucos capecitabin gavag mice order provid evid clinic applic therapeut effect mechan huangqi bazhen decoct chemotherapeut intestin mucos induc capecitabin mice investig paper mice divid differ group given capecitabin intragastr administr treatment drug morpholog featur intestin injuri includ villus height shorten crypt destruct apoptosi revers experiment result show huangqi bazhen decoct signific reduc weight loss diarrhea capecitabin treatment also found gsh px sod improv mda il tnf reduc signific | D052016 | T046 |
36,247,863 | analysi perform gadoxet acid disodium mri predict microvascular invas hepatocellular carcinoma studi aim evalu predict valu gadoxet acid disodium magnet reson imag mri microvascular invas mvi hepatocellular carcinoma hcc | D006528;D008113 | T191 |
36,247,862 | mechan anti inflammatori drug earli treatment oral gingiv mucosa soft tissu trauma traumat tissu develop uncontrol inflammatori respons caus secondari damag injur tissu part bodi therefor prevent wound infect reduc inflammatori respons reduc secondari tissu damag key earli treatment tissu trauma treatment gingiv soft tissu trauma anti inflammatori analges drug reason select accord condit effect reduc inflamm help periodont tissu regener heal howev studi mechan anti inflammatori drug earli treatment oral gingiv mucos soft tissu trauma specif mechan unknown therefor paper explor mechan anti inflammatori drug earli treatment oral gingiv mucosa soft tissu trauma experi provid theoret support clinic treatment gingiv mucosa soft tissu trauma repair paper two anti inflammatori drug levofloxacin metronidazol select measur releas properti vitro vivo white ear rabbit treat gingiv wound treatment experi physiolog characterist intratissu pressur tissu partial pressur oxygen il content pge content determin postinjuri period mechan action anti inflammatori drug determin research result shown anti inflammatori drug signific inhibit content il pge gingiv soft tissu injuri reduc local inflammatori respons acceler tissu heal | D015232;D015850 | T121;T129;T116;T109;T125 |
36,247,861 | nurs teach curriculum set introduc postcompet model vision internet informat nurs curriculum modern improv student skill meet recent trend medic healthcar field curriculum improv base expert recommend author inform data differ web sourc challeng task improv readabl understand curriculum real time standard consid fact articl introduc refin curriculum internet inform analysi rc iia method propos method incorpor distribut internet journal previous curriculum inform within activ nurs syllabus prevent repetit less inform content within activ curriculum besid classif learn knowledg base represent use within curriculum improv compet base refin inform recommend base curriculum prefer vari inform across differ standard propos analysi method reli exist distribut inform across multipl curriculum provid leverag visibl prolong stealth nurs curriculum | D003479;D020407 | T065;T170;T073 |
36,247,860 | comput tomographi angiographi b mode ultrasonographi artifici intellig plaqu segment algorithm perfor local prepar free anterolater femor flap research aim investig accuraci u shape network unet base comput tomographi angiographi cta b mode ultrasonographi us perfor local free anterolater thigh flap altf base unet fusion deep supervis mechan squeez excit modul attent mechan introduc optim algorithm cta segment model da unet establish segment perform da unet algorithm compar condit patient plan receiv altf surgeri select research object accord differ preoper local method divid group cta group b b mode us case group combin actual situat surgeri diagnost accord rate sensit sen specif distanc perfor locat actual locat compar two group dice coeffici jaccard index sen area curv auc averag hausdorff distanc avd da unet segment algorithm respect result signific better algorithm p group diagnost accord rate sen specif patient respect higher patient group b signific p show accuraci cta unet base da unet segment model perfor local altf better b mode us thus refer could provid prepar free altf clinic applic | D061525;D058226;D019651 | T061;T020;T023;T046;T031 |
36,247,859 | comprehens review smart health care applic paradigm challeng case studi growth advanc deep learn dl internet thing iot figur way modern contemporari world integr various technolog distinct field viz agricultur manufactur energi transport suppli chain citi healthcar research identifi feasibl integr deep learn cloud iot enhanc overal autom iot may prolong applic area util cloud servic cloud even prolong applic data acquir iot devic like sensor deep learn diseas detect diagnosi studi explain summari various techniqu util smart healthcar ie deep learn cloud base iot applic smart healthcar fog comput smart healthcar challeng issu face smart healthcar present wider scope intend particular applic aspati monitor diseas detect diagnos technolog use develop smart system outlin smart health bestow qualiti life conveni comfort live made possibl servic provid smart healthcar system shss sinc healthcar massiv area enorm data broad spectrum diseas associ differ organ immens research done overcom drawback tradit healthcar method deep learn iot effect appli healthcar sector autom diagnos treatment process even rural area remot applic may includ diseas prevent diagnosi fit patient monitor food monitor mobil health telemedicin emerg system assist live self manag chronic diseas | D000080487;D017216 | T058;T170 |
36,247,858 | diagnost prognost valu dach methyl sensit esophag cancer radiotherapi detect methyl status cell fate determin dach gene esophag cancer tissu explor predict valu methyl dach sensit radiotherapi esophag cancer cancer tissu correspond paracancer tissu specimen normal esophag mucos tissu patient admit hospit radic esophag cancer radiotherapi januari april collect methyl status dach detect methyl specif polymeras chain reaction msp esophag cancer patient divid radiotherapi sensit radiotherapi insensit group accord efficaci radiotherapi methyl status dach compar two group test use analyz relationship methyl status dach clinicopatholog characterist esophag cancer patient kaplan meier surviv curv use analyz relationship methyl status dach radiotherapi sensit surviv esophag cancer patient cox proport risk model use analyz independ influenc factor affect radiotherapi sensit esophag cancer patient methyl rate dach esophag cancer tissu higher paracancer tissu normal tissu differ statist signific p patient esophag cancer complet radiotherapi includ patient radiotherapi sensit patient radiotherapi insensit dach methyl rate esophag cancer patient radiotherapi sensit group lower radiotherapi insensit group differ statist signific p dach methyl rate esophag cancer patient tnm stage iii iv tumor differenti degre hypofraction lymph node metastasi higher differ statist signific p kaplan meier curv show median surviv time patient dach methyl radiotherapi month shorter patient dach unmethyl radiotherapi month differ surviv curv two group statist signific p median surviv time patient radiotherapi sensit group month longer patient radiotherapi insensit group month differ two group statist signific p median surviv time patient radiotherapi sensit group month longer patient radiotherapi insensit group month differ surviv curv two group statist signific p result multifactori cox regress model show tnm stage stage iii iv hr ci tumor hypofraction hr ci presenc lymph node metastasi hr ci dach methyl hr ci may increas risk insensit radiotherapi patient esophag cancer p rate dach methyl esophag cancer tissu increas methyl status dach relat radiotherapi sensit surviv esophag cancer patient expect new target diagnosi treatment esophag cancer patient | D004938 | T191 |
36,247,857 | express sr bi lxr macrophag origin foam cell mous raw regul astragalus polysaccharid investig influenc astragalus polysaccharid ap express sr bi scaveng receptor bi lxr raw macrophag origin foam cell | D050197;D005487 | T047;T046;T025 |
36,247,856 | auricular point press bean continu intervent mg curat effect relationship prognosi elder mhd suffer effect auricular point press bean continu intervent microglobulin mg curat effect relationship prognosi elder mainten hemodialysi mhd suffer explor examin select elder mhd suffer treat hospit februari februari examin object random divid two set case examin set case contrast set suffer contrast set given routin attend care suffer examin set given auricular acupunctur combin continu attend intervent experiment result show mhd suffer auricular acupunctur combin continu attend therapi period effect enhanc clinic therapi effect enhanc suffer inflammatori index renal function index reduc readmiss rate enhanc prognosi qualiti life | D015669;D011788 | T078;T029 |
36,247,855 | systemat review efficaci safeti tradit chines medicin granul associ hormon treat primari nephrot syndrom children systemat evalu efficaci safeti tradit chines medicin tcm granul associ hormon treat primari nephrot syndrom pns children | D008516;D009404 | T060;T047;T091 |
36,247,854 | analysi express inflammatori factor cell lymphocyt patient orthoped trauma infect risk factor sinc orthoped patient wound open clinic practic postop wound infect condit prone occur pose vari degre threat patient prognosi life health paper retrospect studi conduct orthoped trauma patient hospit januari januari includ patient postop infect patient without infect detect compar level inflammatori factor level cell lymphat group index differ roc curv drawn analyz diagnost efficaci postop infect indic patient orthoped trauma differ baselin data two group compar multivari logist regress analysi perform infect status experiment result show il il crp infect group patient signific higher uninfect group cd cd cd signific lower uninfect group mean patient infect orthoped trauma disord state immun cytokin function therefor postop infect effect assess earli combin detect indic addit analysi clinic data show oper time number under diseas surgic method also risk factor postop infect | D007376;D015850 | T129;T121;T116 |
36,247,853 | efficaci safeti peginterferon entecavir tenofovir treatment chronic hepat b genotyp c articl discuss clinic valu pegyl interferon peg ifn combin entecavir tenofovir treatment chronic hepat b chb genotyp c patient patient chb genotyp c divid three group control group entecavir group tenofovir group accord differ treatment method efficaci advers reaction ar three group observ month treatment drug withdraw clinic efficaci safeti three treatment method evalu experiment result show sustain respons rate rr tenofovir entecavir group higher control incid total ar tenofovir group signific higher control entecavir group peg ifn entecavir tenofovir effect tenofovir antivir effect | D019694 | T047 |
36,247,852 | qualiti control clinic medic laboratori base mobil medic edg comput today depart mani healthcar organ suffer data storag network speed doctor diagnos patient help treatment process need well manag clinic trial data main basi judg patient condit medic process rapid develop clinic laboratori technolog china import achiev made medicin clinic hospit use larg number differ type test reagent equip accuraci test data becom key issu test result accuraci test data come zero error clinic test deriv rigor oper rigor tester clinic test articl dedic qualiti control analysi research base mobil medic edg comput clinic trial articl introduc relev theori mobil medic edg comput technolog qualiti control method refer studi general medic student clinic compet problem solv communic skill procedur histori physic examin critic non critic indic object structur clinic examin osc addit routin test group qualiti control group strengthen import aspect medic test design conduct compar experi experi prove qualiti control group strengthen import link medic test higher index routin test group aspect among detect accuraci rate reach great signific improv detect link patient condit follow diagnosi treatment link | D013337 | T097 |
36,247,851 | effect radioimmunoassay accuraci thyroid hormon detect present import method detect thyroid hormon hospit china radioimmunoassay besid radioimmunoassay blood test antibodi test method thyroid hormon detect howev long term clinic investig accuraci result thyroid hormon detect radioimmunoassay affect mani factor possibl influenc factor includ inaccur thyroid hormon test result due improp way blood collect nurs improp way keep transport blood sampl nurs therefor paper analyz discuss influenc factor accuraci thyroid hormon detect radioimmunoassay technolog paper conduct research use statist analysi clinic data improv separ method qualiti control laboratori blood specimen collect method radioimmunoassay occur antibodi batch case improv separ method qualiti control laboratori mismatch item account error method oper account unmatch specimen biochem characterist clinic manifest thyroid hormon blood sampl collect method research found mild hemolysi signific effect measur result sever hemolysi tendenc affect result blood collect tube effect test result mild hemolysi refer increas rate red blood cell destruct due various intern extern factor bodi symptom mild hemolysi occur general obvious sever hemolysi refer diseas caus blood group incompat main refer immun hemolysi caus blood group incompat mother babi well sever jaundic sever anemia statist analysi clinic data found among patient reason inaccuraci result use radioimmunoassay technolog follow patient inaccur due person factor result due hospit factor total patient inaccur result measur thyroid hormon affect mani factor reason influenc factor accuraci radioimmunoassay clarifi appropri measur taken deal give full play role radioimmunoassay improv detect | D013974;D014284 | T125;T121;T116;T109 |
36,247,850 | meta resolv risk factor nosocomi infect patient undergo thorac surgeri know various complic may occur surgeri postop bleed infect common clinic practic postop infect main manifest abdomin abscess periton fungal infect thorac surgeri common clinic oper direct deal relev lesion better curat effect usual obtain howev patient undergo thorac surgeri general sever ill low immun resist long durat complic surgic treatment process therefor probabl nosocomi infect high mani risk factor infect occurr hai increas suffer econom burden patient workload medic staff also prolong hospit time patient reduc turnov rate hospit bed caus unnecessari econom loss affect social econom benefit hospit base paper propos analyz risk factor nosocomi infect patient undergo thorac surgeri provid refer prevent control nosocomi infect paper analyz actual situat nosocomi infect citi hospit use meta analysi determin factor nosocomi infect perspect relev research literatur meta analysi result show patient older year twice risk postop infect compar patient younger year | D003428;D013903 | T047;T091 |
36,247,849 | observ curat effect acupunctur tonifi kidney remov blood stasi combin radiofrequ surgeri patient nsclc diagnost efficaci combin detect ntx bgp cyfra occurr bone metastas curat effect observ acupunctur tonifi kidney remov blood stasi combin radiofrequ surgeri patient non small cell lung carcinoma nsclc diagnost efficaci combin detect ntx bgp cyfra bone metastas investig nsclc patient admit hospit januari decemb select examin two set patient random divid studi set control set use random number tabl method case set patient control set given ct guid percutan radiofrequ ablat therapi patient studi set given combin acupunctur therapi tonifi kidney remov blood stasi basi therapi control set experiment result show nsclc patient applic kidney tonifi stasi remov acupunctur therapi combin radiofrequ surgeri notori enhanc clinic therapi effect enhanc qualiti life patient detect ntx bgp cyfra indic effect predict prognosi | D015670;D001859;D002289;D008175 | T061;T191 |
36,247,848 | diagnost valu comparison multislic spiral computer tomographi magnet reson imag artifici intellig algorithm diagnos occult fractur knee joint aim studi explor applic valu multislic spiral computer tomographi msct magnet reson imag mri intellig algorithm diagnosi occult fractur knee joint ofkj patient negat x ray examin suspect fractur includ research accord examin method patient divid msct group mri group diagnost result two method compar compar tradit algorithm explor superior result demonstr algorithm appli studi clearer segment tradit algorithm run signific faster algorithm result msct mri patholog examin differ statist signific p specif accuraci sensit posit predict valu ppv negat predict valu npv msct respect coincid rate miss diagnosi rate misdiagnosi rate respect compar mri differ signific statist p segment effect msct closer standard segment higher effici msct intellig algorithm produc better diagnost perform higher detect rate mri diagnos ofkj could use clinic auxiliari diagnosi evalu ofkj deserv applic valu | D005596 | T037 |
36,247,847 | mri imag omic risk factor analysi pwmd prematur infant base fuzzi cluster algorithm magnet reson imag mri characterist periventricular white matter damag pwmd prematur infant use fuzzi c mean cluster algorithm fcm explor influenc factor clarifi total prematur infant admit neonat depart hospit februari februari select depth investig accord occurr pwmd divid pwmd group simpl prematur deliveri group case group preterm infant examin mri chang imag characterist appar diffus coeffici adc valu analyz clinic inform subject collect influenc factor pwmd preterm infant analyz multivari regress analysi first magnet reson imag mri examin case punctur cluster linear lesion case case case respect experiment result show pwmd preterm infant present punctat cluster high linear signal mri manifest caus downward trend adc valu caus respiratori distress low birth weight prematur ruptur membran respiratori tract infect risk symptom | D007234;D066127 | T033;T023;T100;T024 |
36,247,846 | deconstruct knee cartilag injuri athlet use mr imag base artifici intellig segment algorithm knee joint second largest joint human bodi wide rang function activ strong support human bodi moreov cartilag knee joint hyalin cartilag relat brittl vulner trauma clinic work damag articular cartilag diseas high rate orthoped visit paper experiment group case includ observ patient acut articular cartilag injuri oa diagnos knee arthroscopi experiment group control group strenuous exercis one day mri magnet reson imag sat minut examin convent scan sagitt fse twi fse twi fs fse twi fs fse twi fs pdwi coron fs pdwi sequenc normal control group color map generat workstat articular cartilag divid midsagitt plane patellar cartilag tibial plateau rough divid upper middl lower anterior middl posterior third order ensur maximum compar result artifici intellig segment algorithm use divid region interest equal central part partit select much possibl measur valu three partit cartilag measur one one averag comparison result valu cartilag part accord patellar cartilag femor cartilag tibial cartilag p valu respect therefor earli detect earli treatment articular cartilag injuri great signific perform athlet competit level extens sport life | D002357;D002358 | T047;T024 |
36,247,845 | evalu abc bleed score ttr score risk bleed anticoagul patient nonvalvular atrial fibril complic coronari heart diseas explor predict valu abc bleed score ttr score risk bleed patient nonvalvular atrial fibril nvaf complic coronari heart diseas chd anticoagul | D001281;D003327;D020521 | T047;T046 |
36,247,844 | fertil status marri peopl live hivaid china order analyz fertil status marri peopl live human immunodefici virus hiv acquir immun defici syndrom aid plha reproduct age china sampl marri plhas age china select use stratifi cluster sampl method particip face face interview structur questionnair among fertil status influenc factor plhas statist analyz experiment result show marri plha reproduct age china high proport children fertil status fertil intent femal higher male proport unwant pregnanc hiv diagnosi femal high | D000163;D015658 | T047 |
36,247,843 | diagnost signific f fdg petct imag coupl magnet reson imag entir bodi bone metastas see f fluorodeoxyglucos positron emiss tomographycomput tomographi f fdg petct imag pair mr diffus imag help doctor diagnos bone metastas | D001859;D019788 | T191;T130;T109 |
36,247,842 | detect diagnost valu cytokin serum children acut viral enceph acut viral enceph one serious infecti diseas order analyz diagnost efficaci serum procalcitonin pct c reactiv protein crp sb protein acut viral enceph total children acut viral enceph juli decemb select includ viral enceph group result show sb protein model high specif sensit simpl oper provid new idea direct differenti diagnosi improv optim relev clinic diagnosi treatment scheme high clinic valu | D018792;D000077740 | T123;T047;T116 |
36,247,840 | narrat worst experi associ peritraumat distress covid pandem mix method studi usa itali background although symptom posttraumat stress disord ptsd associ covid pandem experi studi explor yet associ specif covid narrat peritraumat distress precursor ptsd object explor worst experi associ peritraumat distress first wave covid pandem method adult resid n us n itali n complet onlin survey includ socio demograph data covid relat experi peritraumat distress inventori open question worst experi first period covid pandem april may themat content analysi tca conduct answer open question classif regress tree cart analysi use identifi theme best predict clinic level peritraumat distress result main tca theme relat particip worst covid experi anxieti threat loss anger stress constrict threat preval theme correl experi quarantin infect love one receiv diagnosi us particip descript worst experi relat life threat loss italian report threat world stress social isol feel trap cart analysi main predictor perceiv negat effect covid crisi among covid relat threat self experi robust predictor absenc depriv resourc experienc high level anxieti robust predictor conclus studi provid evid util mix method approach conceptu experi associ covid pandem risk traumat symptom find may inform healthcar intervent polici tackl new challeng pose covid pandem highlight clinic signific level peritraumat distress symptom preval covid pandemicclin signific level peritraumat distress covid pandem relat experi life threat resourc depriv anxieti cross cut theme articul themat content analysi anxieti threat loss anger stress constrictionth us italian particip descript worst experi differ subtl import way american report life threat loss compar italian report threat world stress social isol feel trap | D000086382;D013313 | T047;T067;T048 |
36,247,731 | hear touch multisensori integr mate choic mate choic potent generat divers fundament pillar sexual select evolut mate choic multistag affair complex sensori inform elabor action use identifi scrutin evalu potenti mate partner wide accept communic mate assess reli multimod cue studi investig mechan control fundament behavior restrict focus domin sensori modal use speci examin vision human smell rodent howev despit undeni import initi recognit attract approach toward potenti mate modal gain relev interact progress amongst touch audit review focus recent find touch audit contribut evalu choic mate partner outlin current knowledg regard neuron circuit process touch audit amongst other context mate choic ask neural circuit connect area studi light multisensori integr | D014110;D055698 | T041;T042 |
36,247,730 | probe structur function locus coeruleus project cns motor center brainstem nucleus locus coeruleus lc send project forebrain brainstem cerebellum spinal cord sourc neurotransmitt norepinephrin ne area year lc consid homogen structur function ne would releas uniform act simultan cell circuit receiv lc project howev recent studi provid evid lc modular design segreg output channel potenti differenti releas action ne project field new find prompt radic shift think lc oper demand revis theoret construct regard impact lc ne system behavior outcom health diseas within context major gap knowledg relationship lc ne system cns motor control center know much organ lc ne system respect sensori cognit circuitri impact lc output sensori guid behavior execut function much less known role lc ne pathway motor network oper movement control start point close gap understand propos use intersect recombinas base viral genet strategi trac trace axon collater well establish ex vivo electrophysiolog assay character effer connect physiolog attribut mous lc motor network project neuron novel hypothesi test lc cell project cns motor center scatter throughout rostral caudal extent nucleus collect display common set electrophysiolog properti addit expect find lc project neuron maintain organ network axon collater capabl support select synchron releas ne motor circuitri purpos coordin regul oper across network respons balanc movement dynam investig hypothesi advanc knowledg role lc ne system motor control provid basi treat movement disord result diseas injuri normal age | D008125;D009474 | T023;T025 |
36,247,729 | neural circuit monogam behavior interest studi neural circuit relat mate behavior mate choic monogam speci lie parallel found human social structur sexual behavior mammal exhibit social monogami potenti expand understand human neurobiolog under mechan extens research suggest social monogami oppos non monogami mammal consequ neural encod sociosensori inform sexual partner increas reward valu thus reinforc valu mate outweigh reward valu mate potenti sexual partner mechan reinforc social relationship breed pair common defin pair bond addit accentu prosoci behavior toward partner characterist behavior may appear territori partner guard select aggress toward unfamiliar conspecif biparent care concomit social buffer distress upon partner separ also observ follow work intend overview compar known neural function circuit relat mate sexual behavior monogam mammal particular discuss report cricetid rodent microtus peromyscus genus new world primat nwp callicebina subfamili titi monkey marmoset callithrix spp addit mention main factor modul neural circuit relat social monogami modul may reflect phenotyp differ ultim creat wide observ divers social behavior | D010152;D011323 | T015;T054 |
36,247,728 | reliabl tms measur use convent hand hold method differ number stimuli tibiali anterior muscl healthi adult object object studi determin reliabl corticomotor excit measur use convent hand hold transcrani magnet stimul tms method tibiali anterior ta muscl healthi adult number stimuli requir reliabl assess method forti healthi adult particip three repeat session corticomotor excit assess term rest motor threshold rmt slope recruit curv rc peak motor evok potenti amplitud pmep mep latenc use convent tms method first two session conduct rest interv h last session conduct day afterward except rmt three outcom measur elicit block first stimuli analyz respect within day session vs day session vs reliabl four outcom measur assess use intraclass correl coeffici icc standard error measur minimum detect differ confid interv result good excel within day day reliabl found tms induc outcom measur examin use stimuli icc except pmep show day reliabl moder level icc number three stimuli adequ achiev minimum accept within day reliabl tms induc paramet day reliabl mep latenc regard day reliabl rc slope pmep least seven nine stimuli recommend respect conclus find indic high reliabl corticomotor excit measur tms adequ number stimuli ta muscl healthi adult result interpret caveat specif methodolog choic equip set characterist sampl current studi clinic trial registr http wwwchictrorgcn identifi chictr | D009044;D050781 | T062;T023;T029;T061 |
36,247,727 | prelimb cortex respond male ultrason vocal presenc male pheromon femal mice sensori signal critic perform adapt social behavior copul male mice emit ultrason vocal usv previous studi shown femal mice exhibit approach behavior toward sound sourc male usv expos male pheromon exocrin gland secret peptid esp femal mice exhibit prefer toward particular type male usv find suggest male usv modul femal courtship behavior howev remain unclear brain region cell type neuron involv neuron process male usv clarifi issu immedi earli gene analysi behavior analysi neurochem analysi perform situ hybrid analysi c fos mrna multipl brain region show neuron prelimb cortex respons present male usv presenc esp furthermor studi found activ prelimb cortex correl durat femal explor behavior toward sound sourc usv final use doubl immunohistochemistri present studi show prelimb neuron respond present male usv presum excitatori glutamaterg neuron result suggest prelimb cortex may facilit femal courtship behavior respons male usv | D014465;D014828 | T055;T070 |
36,247,720 | sport injuri risk prevent mri imag perform athlet physic educ order effect prevent athlet injuri sport train physic educ method risk prevent sport injuri base mri technolog propos method solv problem injuri prevent sport train studi associ analysi algorithm data mine technolog research mri technolog experiment result show averag predict error ct us consid model predict accur conclus method risk prevent sport injuri base mri technolog effect prevent injuri athlet process sport train reduc injuri rate athlet | D001265;D013177 | T056;T037 |
36,247,719 | evalu pelvic floor dysfunct pelvic floor ultrasonographi total hysterectomi cervic cancer studi valu pelvic floor ultrasonographi evalu pelvic floor dysfunct pfd total hysterectomi cervic cancer | D017773;D002583 | T023;T191 |
36,247,488 | combin donor recipi obes risk graft loss kidney transplant background preval obes increas global appreci effect donor recipi dr obes graft outcom increas import method cohort adult kidney transplant recipi identifi use srtr use cox proport hazard model examin associ dr obes pair bodi mass index bmi kgm death censor graft loss dcgl caus graft loss logist regress examin risk delay graft function dgf day graft loss also explor associ dr weight mismatch kg kg r r kg r outcom stratifi dr obes pair result relat non obes dr obes dr highest risk outcom dcgl hr ci caus graft loss hr ci dgf ci earli graft loss ci donor obes modifi risk recipi obes dcgl p caus graft loss p dgf earli graft loss known associ dr weight mismatch dcgl attenu either donor recipi obes conclus dr obes status impact earli late post transplant outcom | D006084;D016030;D009765;D014019;D066027 | T061;T098;T042;T047;T101 |
36,247,201 | studi associ dietari habit pattern frailti elder cross section survey communiti china purpos studi explor effect chines dietari habit pattern frailti among elder peopl xian communiti also sought provid dietari suggest prevent frailti | D000073496 | T033;T184;T046 |
36,247,200 | healthi age reflect innat adapt immun paramet aim paper establish quantifi relat healthi age innat adapt immun paramet indic age relat diseas | D000073656 | T102 |
36,247,199 | associ poor nutrit status increas risk subsequ vertebr fractur elder peopl percutan vertebroplasti relationship poor nutrit state risk fractur investig studi aim investig abil control nutrit status conut geriatr nutrit risk index gnri predict incid subsequ vertebr fractur svf percutan vertebroplasti pvp | D050815;D044342;D058866;D016103;D054854 | T061;T047;T046;T037 |
36,247,198 | covid earli case diseas spread emerg global spread sever acut respiratori syndrom coronavirus sar cov critic understand prevent control futur viral pandem review tool use retrospect search limit result obtain china franc itali usa examin possibl scenario emerg sar cov human popul consid chines citi wuhan first case atyp pneumonia attribut sar cov diseas spread worldwid possibl superspread event includ wuhan base th militari world game octob chines new year holiday januari februari sever clue point earli region circul sar cov northern itali lombardi soon septemberoctob franc novemberdecemb goal prevent futur pandem call addit retrospect studi design trace origin sar cov | D000086382 | T047;T067 |
36,247,197 | covid pandem impact academ global health program result larg intern survey covid pandem caus signific disrupt intern communic travel academ global health program aghp high incom countri hic low middl incom countri lmic given import intern travel communic aghp pandem like consider impact educ research administr compon program date substant studi determin impact covid pandem aghp hic lmic studi assess impact result adapt aghp pandem realiti goal share strategi approach | D000086382;D014943 | T078;T047;T091;T067 |
36,247,105 | preval chronic pain adult popul israel internet base survey chronic pain cp preval differ studi inconsist rang spain uk | D059350 | T184;T047 |
36,247,104 | efficaci levobupivacain versus levobupivacain plus dexmedetomidin infiltr post tonsillectomi analgesia random control trial studi evalu analges effect levobupivacain infiltr tonsil bed combin levobupivacain dexmedetomidin patient undergo tonsillectomi | D000698;D020927;D014068 | T061;T121;T109 |
36,247,103 | analges medic fibromyalgia patient cross section studi approv drug fibromyalgia syndrom fms europ german guidelin amitriptylin duloxetin pregabalin recommend temporari use aim studi cross section investig current practic medic fms patient germani systemat interview patient fms particip larger studi patient stratifi subgroup without decreas intraepiderm nerv fiber densiti drug common use treat fms pain nonsteroid anti inflammatori drug nsaid patient metamizol amitriptylin frequent analges treatment regimen demand pain attack drug administ daili remain regimen median pain relief self rate patient numer rate scale point nsaid metamizol amitriptylin drug discontinu due lack efficaci rather side effect acetaminophen flupirtin select serotonin reuptak inhibitor reduct pain sever best achiev nsaid metamizol hypothesi decreas intraepiderm nerv fiber densiti might repres neuropath subtyp fms would associ better effect drug target neuropath pain could confirm cohort mani fms patient take demand medic line current guidelin random clinic trial need assess drug effect fms subgroup | D005356;D009437 | T184;T047 |
36,247,102 | psycholog profil relev temporomandibular disord symptom preorthodont patient temporomandibular disord tmds refer group heterogen musculoskelet diseas divers clinic symptom undetermin aetiolog psycholog profil close relat onset treatment outcom tmds | D003863;D013705 | T184;T047;T048 |
36,247,101 | rapid improv neck disabl mobil sleep qualiti chronic neck pain treat fu subcutan needl random control studi chronic neck pain common musculoskelet disord caus overus neck upper back muscl poor postur common combin limit rang motion neck shoulder case recov within day howev symptom often recur easili fu subcutan needl fsn new therapeut approach use treat patient chronic neck pain howev solid evid support effect fsn chronic neck pain disabl | D059350;D004561 | T061;T184;T047 |
36,247,090 | use laney p control chart monitor covid case jordan research examin use laney p control chart applic test rule assess government intervent throughout covid pandem understand certain activ event took place affect infect rate data infect rate ir collect octob march ir calcul divid number confirm case number pcr polymeras chain reaction test perform ir data subsequ plot laney p control chart use minitab softwar chart therebi allow us studi effect infect rate govern move restrict movement activ popul well result eas restrict restrict measur prove effect decreas infect rate wherea relax measur opposit effect typic test signal consid indic chang process although situat observ slight chang accompani signal regardless analysi show case use test rule rapid detect pattern chang ir allow remedi action taken without delay studi use laney p control chart monitor covid ir compar perform ewma control chart addit analyz perform various test rule detect ir chang compar laney p control chart ewma control chart data show case laney p control chart abl identifi chang ir faster compar perform differ test detect chang ir one see particular test outperform other case also recommend analyz data point singl stage multistag analys accord new perspect rather tradit one use process improv project accord singl stage analysi give complet pictur infect rate chang overal wherea multistag analysi sensit small chang | D000086382 | T047;T067 |
36,247,089 | explor potenti biomark ferroptosi mechan therapeut target associ cutan squamous cell carcinoma via integr transcriptom analysi cutan squamous cell carcinoma cscc lead caus death patient nonmelanoma skin cancer nmsc howev unclear pathogenesi cscc limit applic molecular target therapi | D002294;D000079403;D035683;D012878 | T123;T191;T114;T043 |
36,247,088 | glucos determin singl nm puls photoacoust techniqu multipl calibr extern factor photoacoust spectroscopi prove potenti method noninvas blood glucos detect use nm puls laser excit photoacoust signal glucos solut explor influenc differ glucos concentr photoacoust signal analyz sensit photoacoust signal glucos wavelength design simpl photoacoust cell structur use focus ultrason transduc receiv signal reduc signal attenu term result found high concentr glucos solut result strong linear discrimin concentr close human bodi level signal differ obvious therefor explor extern factor affect photoacoust signal detail propos calibr method calibr signal generat low concentr glucos solut also good linear | D005947;D061088 | T060;T123;T121;T109 |
36,247,084 | fuzzi approxim entropi extrema base multipl move averag novel approach obstruct sleep apnea screen obstruct sleep apnea osa respiratori diseas associ autonom nervous system dysfunct novel method analyz osa depend heart rate variabl fuzzi approxim entropi extrema base multipl move averag emma fapen effect assess sympathet tension limit therebi realiz good perform diseas sever screen | D020181 | T047 |
36,247,080 | inhibit madl mediat pulmonari fibrosi impair mitochondri function induct cell senesc idiopath pulmonari fibrosi ipf chronic irrevers progress interstiti lung diseas character recurr alveolar epitheli cell injuri fibroblast hyperprolifer cumul deposit extracellular matrix lead alveolar destruct lung mitot arrest defici like madl compon mitot spindl assembl checkpoint prevent onset anaphas chromosom proper align metaphas potenti therapeut target cancer howev role madl pulmonari fibrosi explor analyz express madl lung tissu control subject ipf patient mice bleomycin induc fibrosi via ihc qrt pcr western blot analysi examin role madl ros product mitochondri function cell senesc establish profibrot microenviron found madl high upregul alveolar epitheli cell fibrot lung tissu patient ipf mice bleomycin induc fibrosi loss madl express activ led decreas cell viabil prolifer cell subsequ mechanist investig demonstr inhibit madl damag mitochondria led augment ros product cellular senesc thus promot establish profibrot microenviron taken togeth result reveal allevi alveolar epitheli cell mitochondri damag aris augment madl may novel therapeut strategi mitig pulmonari fibrosi | D054990 | T047 |
36,247,079 | nasopharyng wash normal salin decreas sar cov viral load random pilot control trial although great progress made past year scientif understand biolog epidemiolog pathogenesi sever acut respiratori syndrom coronavirus sar cov case morbid fatal rate remain great concern continu challeng healthcar resourc worldwid novel variant emerg therefor urgent need afford readili avail strategi reduc viral transmiss previous studi non covid patient demonstr administr low salt isoton na isoton salin na solut associ immedi signific reduct microbi antigen relat declin microbi burden aim present studi determin effect nasal wash normal salin nasopharyng viral load outcom hospit patient covid pneumonia | D000086382;D000086402 | T047;T005;T067 |
36,247,078 | efficaci high flow nasal cannula versus convent oxygen therapi obes patient periop period systemat review meta analysi obes risk factor sever airway obstruct hypoxemia high flow nasal cannula hfnc consid novel method oxygen therapi efficaci hfnc obes patient controversi meta analysi aim assess efficaci hfnc compar convent oxygen therapi cot obes patient periop period | D063087;D012131 | T061;T047;T046 |
36,247,045 | diagnost challeng helicobact pylori infect ethiopia communiti base cross section studi resourc constrain countri accur diagnosi helicobact pylori infect remain challeng studi aim assess clinic util local avail serolog stool antigen test kit manag peopl suspect h pylori infect ethiopia | D004415;D016481;D016480 | T184;T047;T007 |
36,247,044 | patholog characterist prognost determin outcom patient diagnos colorect adenocarcinoma univers teach hospit kigali worldwid colorect cancer crc second diagnos cancer femal third men aris epithelium colorectum known colorect cancer common develop countri develop countri may due inaccur data exist diseas region combin embrac western lifestyl express current trend chang cultur social lifestyl practic play major part etiolog crc aim studi document epidemiolog patholog characterist prognost determin patient diagnos crc rwanda data patient file review glass slide case kigali univers teach hospit chuk statist analyz patient characterist describ mean frequenc accord comparison perform use chi squar test fisher exact test odd ratio confid interv ci surviv curv plot use kaplan meier method log rank test use assess statist differ observ surviv curv categor variabl p valu consid statist signific statist analys perform use statist product servic solut spss graphpad prism medcalc accord mean age particip year main symptom rectal bleed rectal adenocarcinoma nos repres convent adenocarcinoma tumor grade ii common stage ptn resect margin free lympho vascular invas case high immun respons case case still aliv end data collect patient overal surviv year prognost determin also affect outcom studi overal surviv period year crc diagnos rwanda | D000230;D015179 | T191 |
36,247,043 | kiwifruit kiwifruit extract treatment constip systemat review meta analysi systemat review aim summar evid determin effect kiwifruit kiwifruit extract treatment constip | D011620 | T123;T121;T109 |
36,246,995 | cardiac vagal activ associ gut microbiom pattern women exploratori pilot studi function reciproc gut microbiom vagal nerv activ suggest howev human studi address phenomenon limit | D000069196;D064307 | T032;T007;T028;T001 |
36,246,993 | understand medic informat among dental medic student current medic care deepli reli informat stage patient care signific enhanc due use healthcar profession format medic informat result crucial everyday practic howev healthcar studi program alway provid educ use wide varieti system young profession find need learn experi aim studi assess understand medic dental student regard medic informat ict | D004501;D008490;D013337 | T065;T097;T091;T066 |
36,246,992 | greenhous gas emiss percept covid pandem period unpreced histor time industri econom societ activ world great challeng human health ecosystem aspect human endeavor owe covid sar cov cv pandem topic aspect research interest despit negat impact cv pandem also posit report cv pandem reduct gas flare reduct burn fossil fuel automobil exhaust reduct ensu factor greenhous gase emiss one major drive global warm climat chang well environment effluenc henc brief perspect review studi center greenhous gas ghg emiss studi employ method approach analyz alreadi avail research studi exist public databas ghg emiss use percept cv pandem specif find review show meteorolog perspect global respons catastroph ensu cv pandem great influenc reduct ghgs reduct burn fossil fuel automobil industri devic reduct ensu factor ghg emiss henc far truth conclud possibl posit connect cv pandem ghg emiss studi direct impact environ owe negat posit environment consequ cv pandem suggest recommend form futur prospect ghg emiss vis vis global warm climat chang also discuss furthermor suggest improv food secur agricultur pandem cv outbreak period highlight | D000086382;D000074382 | T047;T067;T197 |
36,246,991 | detect radiolabel inflammatori cell macrophag subpopul chronic respiratori diseas result preliminari analys chronic respiratori diseas crds like asthma chronic obstruct pulmonari diseas copd lead caus morbid mortal worldwid alveolar macrophag immun cell exist differ polar statesphenotyp shown play critic role inflammatori process paper differ polar mous bone marrow deriv macrophag bmdm proinflammatori immunomodul radiolabel either mtc l hexamethylen propyleneamin oxim tc hmpao deoxi f fluoro glucos f fdg ga citrat biocompat vivo biodistribut radionuclid label macrophag intraven inject evalu radioact measur perform use packard cobra quantum gamma counter macrophag show higher uptak f fdg tc hmpao ga citrat macrophag show higher uptak radionuclid macrophag use radionuclid biocompat macrophag hour postinject f fdg label macrophag found signific higher lung inflammatori anim respect control mice label macrophag either f fdg tc hmpao affect biodistribut result initi experi indic radionuclid label macrophag may allow higher sensit detect nuclear imag techniqu pet spect confirmatori studi need noninvas imag radiolabel bmdm understand role inflammatori process inher crds | D019788;D008264 | T130;T025;T109 |
36,246,990 | effect differ dose dex anesthesia inflammatori factor hemodynam patient undergo neurosurgeri relationship rss score effect differ dose dexmedetomidin dex anesthesia inflammatori factor hemodynam patient undergo neurosurgeri relationship rss score analyz total patient receiv neurosurgeri hospit march march select accord differ intraop dex dose enrol patient random divid low medium high dose group patient group studi hemodynam index inflammatori factor anesthesia effect ramsay sedat scale rss score compar group experiment result show neurosurgeri compar low dose dex high dose dex better maintain patient intraop hemodynam paramet effect inhibit postop inflammatori respons postop awaken time also relat prolong medium dose dex effect control patient awaken time | D000758;D020927;D009493 | T061;T121;T091;T109 |
36,246,989 | clinic efficaci safeti evalu calcitriol combin bisphosphon therapi postmenopaus osteoporosi base retrospect cohort studi retrospect cohort studi explor clinic efficaci safeti evalu calcitriol combin bisphosphon therapi postmenopaus osteoporosi conduct postmenopaus osteoporosi suffer admit hospit januari june retrospect collect divid contrast set studi set case set contrast set suffer treat bisphosphon studi set basi therapi drug contrast set treat calcitriol capsul first curat effect bone miner densiti standard bone metabol standard two set contrast lumbar spine bone miner densiti vas score qualiti life two set suffer therapi year therapi contrast correl bone miner densiti vas qualiti life suffer analyz last readmiss situat two set one year contrast experiment result show postmenopaus women osteoporosi calcitriol combin bisphosphon therapi notori enhanc clinic therapi effect suffer low advers reaction effect enhanc bone miner densiti bone densiti suffer | D050071;D015663 | T121;T047 |
36,246,988 | clone character gene encod hmgs synthas polygonatum sibiricum saponin polygonatum sibiricum mani pharmacolog activ antitumor antioxid blood sugar lower synthes two pathway mevalon mva methylerythritol phosphat mep hydroxi methylglutaryl coenzym synthas hmgs key enzym mva synthesi pathway express level may affect accumul saponin main activ ingredi p sibiricum studi success clone hmgs hmgs p sibiricum sequenc similar differ site multipl sequenc align result indic n termin sequenc hmgs conserv phylogenet analysi show p sibiricum officinali n tazetta nobil relat common evolutionari ancestor express level hmgss total saponin content differ tissu reveal hmgs express rhizom posit correl total saponin content studi abiot stress effect methyl jasmon meja demonstr express hmgs hmgs gene induc meja peak h fell h present find would provid blueprint futur studi hmgs role triterpenoid biosynthesi p sibiricum | D031384;D012503;D014315 | T002;T109 |
36,246,987 | effect carri continu nurs base mobil platform life children leukemia discharg hospit analyz effect carri continu nurs base mobil platform life children leukemia discharg | D007938;D010351 | T058;T191 |
36,246,986 | multimod mri base radiom nomogram earli differenti recurr pseudoprogress high grade glioma evalu diagnost valu multimod mri radiom base weight fluid attenu invers recoveri imag twi flair combin weight contrast enhanc imag twi ce earli differenti high grade glioma recurr pseudoprogress | D005910;D049451 | T081;T191;T170 |
36,246,985 | genet divers escherichia coli coharbor mcr extend spectrum beta lactamas poultri emerg resist beta lactam agent poultri result multidrug resist mdr phenotyp escherichia coli isol poultri bird appear mobil colistin resist mcr gene poultri sector worsen situat therefor current studi aim investig molecular epidemiolog mcr harbor colistin resist e coli among poultri | D024881;D004927;D029968 | T047;T032;T116 |
36,246,984 | identifi effect nuanxin capsul myocardi injuri induc chronic hypoxia via network pharmacolog analysi experiment valid nuanxin capsul nx hospit prepar guangdong provinci hospit chines medicin use heart failur hf treatment year mechan protect effect investig studi aim explor mechan protect effect nx hf treatment via network pharmacolog analysi experiment valid network pharmacolog analysi predict nx involv regul respons apoptot process hypoxia via protect cellular damag mitochondri dysfunct chronic hypoxia mechan may involv regul pik akt signal pathway hif signal pathway ampk signal pathway mapk signal pathway experiment valid indic nx capabl improv cellular viabil restor cellular morpholog suppress cellular apoptosi cellular nx also exert cardioprotect inhibit mitochondri membran potenti injuri protect mitochondri respiratori energi metabol chronic hypoxia cellular model consist result network pharmacolog predict addit screen activ compound nx good bind key target indic nx may exert protect effect multicompound multitarget conclus nx protect effect hf cellular mitochondri protect chronic hypoxia via multicompound multitarget multipathway mechan may involv modul pik akt signal pathway hif signal pathway ampk signal pathway mapk signal pathway | D004365;D000860 | T123;T184;T121;T033;T046 |
36,246,983 | compar genom character relaxin peptid famili cattl buffalo relaxin famili peptid signific regul reproduct nutrient metabol immun respons mammal present studi aim identifi character relaxin famili peptid cattl buffalo genom level genom proteom sequenc cattl buffalo goat sheep hors camel access ncbi databas blast perform identifi four relaxin peptid gene rln insl insl insl bos taurus wherea three relaxin gene rln insl insl bubalus bubali evolutionari analysi reveal conserv natur relaxin famili peptid buffalo cattl physicochem properti reveal relaxin protein thermost hydrophil basic peptid except insl acid peptid three nonsynonym mutat two rln posit p one insl posit r q bos taurus wherea two nonsynonym mutat one rln posit g w one insl posit g r bubalus bubali identifi insl one indel insert posit bos taurus gene duplic analysi reveal predomin segment duplic inslrln inslinsl gene pair help expand gene famili wherea bubalus bubali show primarili tandem duplic inslrln studi conclud relaxin famili peptid remain conserv evolut gene duplic might help adapt enrich specif function like reproduct nutrient metabol immun respons nonsynonym mutat identifi potenti affect function buffalo | D012065 | T125;T121;T116 |
36,246,982 | antibiot resist genotyp phenotyp characterist frequenc virul factor p aeruginosa isol isol water sampl iran pseudomona aeruginosa pathogen bacterium contamin water studi water sampl evalu p aeruginosa antibiot resist abund virul factor p aeruginosa isol water sampl among type water well spring water show highest p aeruginosa respect posit sampl per type sampl drink water miner water show minor contamin p aeruginosa preval antibiot resist meropenem imipenem erythromycin gentamicin chloramphenicol enrofloxacin zero lowest highest preval antibiot resist observ drink water well water respect abund gene encod antibiot resist p aeruginosa blatem blactx blashv studi also show abund virul gene pseudomona aeruginosa strain isol water algd lasb toxa exo studi suggest water may sourc p aeruginosa contribut releas resist gene food chain cross contamin water transfer process caus contamin p aeruginosa water therefor hygien principl effect reduc water contamin | D060766;D008900;D011552 | T121;T197;T167;T047 |
36,246,981 | burden psoriasi china global level systemat analysi global burden diseas studi psoriasi skin diseas thought relat immun system dysfunct studi aim analyz preval psoriasi china multipl differ categori compar preval global level order bring insight policymak treat diseas | D000071219;D011565 | T081;T047 |
36,246,980 | resveratrol induc apoptosi suppress migrat invas cervic cancer cell inhibit hedgehog signal pathway investig effect mechan resveratrol biolog behavior cervic cancer cell hela cell apoptosi migrat invas hela cell detect flow cytometri wound heal transwel assay express level hedgehog signal pathway protein smoothen smo zinc finger transcript factor gli sonic hedgehog homolog shh detect quantit real time pcr qpcr western blot compar control group resveratrol res signific induc apoptosi inhibit migrat invas hela cell express smo gli shh downregul hela cell treat res hedgehog agonist purmorphamin pur revers res induc increas apoptosi reduct migrat invas hela cell conclus res induc apoptosi suppress migrat invas hela cell inhibit hedgehog signal pathway | D053823;D002583 | T123;T191;T116 |
36,246,979 | anti inflammatori effect chitosan oligosaccharid heart failur mice heart failur current one lead caus death worldwid inflammatori factor play import role develop chitosan oligosaccharid cos low molecular weight form chitosan mani specif biolog activ studi cos effect heart failur studi first time perform transvers arch constrict tac surgeri mice anim model heart failur find reveal cos administr mgkg mgkg dose signific amelior tca induc left ventricular lv hypertrophi well increas lung heart weight mice improv tac induc lv dysfunct dose effect attenu lv cardiomyocyt hypertrophi decreas heart inflamm heart failur mice conclus result indic supplement cos normal diet might effect way prevent myocardi tissu damag patient suffer heart failur | D048271;D006333 | T121;T047;T046;T109 |
36,246,978 | systemat analysi cxc chemokin vascular endotheli growth factor network colon adenocarcinoma perspect angiogenesi tumor angiogenesi play vital role tumorigenesi prolifer metastasi recent vascular endotheli growth factor vegfa cxc chemokin shown play vital role angiogenesi explor express level gene regulatori network prognost valu target predict cxc chemokin vegfa network colon adenocarcinoma coad crucial perspect tumor angiogenesi | D000230;D019743;D003110;D035683;D042461 | T129;T123;T116;T191;T114 |
36,246,977 | clinic analysi case extern auditori canal cholesteatoma surgeri special endoscopi investig clinic characterist surgic experi surgic outcom extern auditori canal cholesteatoma eacc surgeri endoscop otolaryngoscopi | D002781;D018424 | T047 |
36,246,976 | clinic effect flexibl ureteroscop laparoscop treatment parapelv cyst compar clinic effect flexibl ureteroscop laparoscop treatment parapelv cyst | D003560;D052177 | T047;T190 |
36,246,975 | model social support patient inform caregiv dyad close person inform caregiv import provid support indic cancer patient cancer affect coupl codepend system aim studi investig factor influenc multidimension aspect social support cancer patient inform caregiv dyad | D017028;D009369 | T099;T098;T191;T097 |
36,246,974 | downregul matriptas inhibit porphyromona gingivali lipopolysaccharid induc matrix metalloproteinas proinflammatori cytokin suppress tlrnf b signal pathway human gingiv fibroblast matriptas cell surfac proteolyt enzym belong type ii transmembran serin proteas famili mediat inflammatori skin disord cancer progress matriptas may affect develop periodont via proteas activ receptor activ howev cellular mechan matriptas involv periodont unknown studi examin antiperiodont effect matriptas porphyromona gingivali deriv lipopolysaccharid pg lps stimul human gingiv fibroblast hgfs matriptas small interf rna transfect hgfs treat pg lps mrna protein level proinflammatori cytokin matrix metalloproteinas mmp evalu use quantit real time polymeras chain reaction qrt pcr enzym link immunosorb assay elisa respect western blot analys perform measur level toll like receptor tlr interleukin il receptor associ kinas irak transform growth factor activ kinas tak p p pg lps stimul hgfs matriptas downregul inhibit lps induc proinflammatori cytokin express includ express il il tumor necrosi factor tnf il moreov matriptas downregul inhibit pg lps stimul mmp express addit confirm mechan under effect matriptas downregul involv suppress pg lps induc iraktak nf b result suggest downregul matriptas pg lps induc mmp proinflammatori cytokin express via tlr mediat iraktak nf b signal pathway hgfs | D005347;D020781;D010518;D012697 | T047;T116;T126;T025 |
36,246,973 | effect ankl propriocept train prevent ankl injuri martial art athlet martial art routin origin china tradit sport chines nation one outstand sport cultur repres china sinc ancient time excess difficult movement martial art routin competit train caus athlet injuri purpos articl studi effect propriocept train ankl joint prevent ankl injuri martial art athlet ankl strength train ankl propriocept train combin strength train improv dynam static balanc footbal player articl analyz mechan caus martial art athlet injuri propos treatment method ankl injuri experiment part articl martial art athlet male femal select research object random divid male femal experiment group control group experiment group receiv ankl muscl strength train week control group receiv ankl muscl strength train ankl propriocept train experiment result prove ankl propriocept train improv dynam static balanc martial art athlet effect prevent occurr ankl injuri paper dynam balanc abil bipe stand state eye close test reduct stabil index front back direct control group experiment group respect seen stabil train effect experiment group obvious | D016512;D001265;D016139 | T056;T037 |
36,246,972 | cleavag auf coxsackievirus b affect ddx regulatori viral replic itraq proteom analysi coxsackievirus b cvb c proteas c pro play specif cleavag role au rich bind factor auf also call hnrnp consequ disput regul auf downstream molecul studi itraq approach first use quantifi differenti express cellular protein auf overexpress hela cell provid straightforward insight role auf viral infect total differenti express protein dep includ upregul downregul protein identifi dep involv varieti cellular process via go term protein protein interact seri bioinformat analys among dep demonstr import role cellular metabol particular ddx verifi negat regul auf increas cvb infect cell turn promot cvb replic find provid potenti novel idea explor new antivir therapi target | D053487;D000081035;D034502;D040901 | T123;T091;T126;T116 |
36,246,971 | sox knockdown overcom enzalutamid resist castrat resist prostat cancer inhibit notch signal pathway castrat resist prostat cancer crpc still challeng treat dissatisfact androgen signal target therapi forc peopl look treatment strategi therefor studi aim explor role soxnotch signal crpc upregul sox notch hes indic poor progress free surviv pfs crpc patient express protein also upregul enzalutamid resist lncap cell enza r moreov knock sox inhibit malign biolog behavior decreas activ notch signal enza r cell import knock sox obvious revers enzalutamid resist enza r cell ro secretas inhibitor inactiv notch signal exert similar effect last found sox knockdown andor ro suppress tumor growth bone metastasi vivo altogeth studi indic soxnotch signal involv crpc enzym possibl target develop novel treatment crpc | D064129;D055757 | T123;T191;T116 |
36,246,970 | effect analysi nurs method base stratifi emerg knowledg emerg myocardi infarct first aid give immedi first aid patient suffer accident injuri sudden diseas emerg medic personnel arriv scene sent hospit treatment myocardi infarct sever emerg coronari heart diseas often coronari atherosclerosi plaqu ruptur bleed thrombosi lead acut complet occlus coronari arteri acut necrosi myocardium articl aim investig effect stratifi emerg care team assist multidisciplinari first aid knowledg acut myocardi infarct first aid hope reduc probabl acut myocardi infarct first aid nurs care busi process reengin manag idea reach heyday usual defin achiev workflow product reorgan optim corpor strategi valu ad oper process system polici organ structur support articl first outlin concept step medic imag registr analyz characterist current medic imag registr method use two common use medic registr method today studi bpr theori use construct ami emerg care process hospit effect reduc emerg delay time ami patient improv patient emerg respons increas effici emerg nurs rescu work experiment result paper show sensit first four group stiii ii st avl stv stiii sti mv respect sensit relat close greater among stiii ii highest sensit term specif stiii ii st avl stv stiii sti mv respect st mv lowest specif st avl highest specif | D003327;D004632;D009203 | T061;T047;T058;T093 |
36,246,969 | develop optim prognost model associ stem gene hepatocellular carcinoma hepatocellular carcinoma hcc one lethal cancer worldwid associ varieti risk factor cancer stem cell self renew cell promot occurr metastasi tumor enhanc drug resist tumor treatment studi aim develop stem score model assess prognosi hepatocellular carcinoma hcc patient optim treatment singl cell sequenc data gse download geo databas compar gene express hepat stem cell hepatocyt tumor sampl screen differenti express gene relat stem r packag clusterprofil use explor potenti function stem relat gene construct prognost model use lasso regress analysi base tcga gse cohort associ stem score clinic featur drug sensit gene mutat tumor immun microenviron explor r packag rms use construct nomogram model total stem relat gene enrol construct prognosi model kaplan meier analysi prove good perform stem score model predict overal surviv os hcc patient stem score close associ clinic featur drug sensit tumor immun microenviron hcc infiltr level cd cell lower tumor associ macrophag higher patient high stem score indic immunosuppress microenviron studi establish stem relat gene model reliabl predict os hcc find may help clarifi biolog characterist progress hcc help futur diagnosi therapi hcc | D006528;D008113 | T191 |
36,246,968 | effect neurodynam mobil health relat qualiti life cervic deep flexor endur patient cervic radiculopathi random trial cervic radiculopathi disord cervic spinal nerv root affect larg number popul previous mani studi conduct design suitabl protocol manag disord lack qualiti purpos studi compar effect neural mobil cervic isometr health relat qualiti life deep flexor endur cervic radiculopathi | D011843 | T047;T037 |
36,246,967 | link anril gene rs polymorph common atherosclerosi cardiovascular complic hospit base case control studi ukrainian popul patient ac patient las control subject enrol case control studi real time pcr use anril rs genotyp spss softwar packag version ibm usa use data analysi | D050197;D062085 | T123;T047;T046;T114 |
36,246,966 | plasma methyl rnf noninvas diagnosi gastric cancer rnf tumor suppressor gene involv cell develop prolifer apoptosi methyl rnf mrnf lead low express rnf close relat occurr develop gastric cancer gc studi design evalu potenti perform plasma mrnf noninvas biomark diagnosi gc | D005757;D011230;D013274 | T047;T191 |
36,246,965 | segment breast tubul h e imag base dks doubleu net model format breast tubul play import role patholog grade breast cancer breast tubul surround larg number epitheli cell locat subcutan tissu chest shape breast tubul various includ tubular round oval make process breast tubul segment difficult task deep learn technolog capabl learn complex data structur via effici represent could help pathologist accur detect breast tubul hematoxylin eosin h e stain imag paper propos deep learn model name dks doubleu net accur segment breast tubul complex appear h e imag propos dks doubleu net model suggest use densenet modul encod second subnetwork doubleu net util dens featur layer strengthen propag featur extract previous layer order better discov intrins characterist breast tubul complex structur divers shape moreov featur fuse modul call kernel select modul ksm insert output layer two u net branch doubleu net implement multiscal featur fusion via self adapt kernel select sake accur segment breast tubul differ size experi public brac dataset privat clinic dataset shown model achiev better segment perform compar state art model u net doubleu net resunet hrnet deeplabv specif public brac dataset method produc f score outperform f score u net doubleu net hrnet respect much better perform deeplabv resunet respect privat clinic dataset propos model achiev f score shown improv perform u net doubleu net hrnet deeplabv resunet respect superior perform could also observ compar propos dks doubleu net other use metric dice miou | D007091 | T066 |
36,246,964 | reliabl valid korean version crohn ulcer coliti questionnair patient inflammatori bowel diseas ibd decreas qualiti life qol improv treatment goal cucq verifi simpl effect qol measur tool valid korean version cucq approv develop | D003093;D003424;D015212 | T047 |
36,246,963 | prognost valu gimap role promot immun cell infiltr tumor microenviron lung adenocarcinoma gimap recogn import regul carcinogenesi develop lung cancer function gimap tumor microenviron tme lung cancer unclear studi investig express variat gimap lung adenocarcinoma luad explor associ infiltr immun cell cancer genom atlas tcga data gene express omnibus geo data analyz infiltr immun cell identifi timer tumor immun estim resourc tisidb integr repositori portal tumor immun system interact gimap express declin non small cell lung cancer nsclc correl poor overal surviv os luad indic gimap promis prognost biomark luad gimap mutat frequenc tcga cohort relev express immun compon timer cibersort analysi confirm high gimap express possibl promot immun cell infiltr tme low gimap impair efficaci immunotherapi target common immun check point inhibitor ici go gene ontolog kegg kyoto encyclopedia gene genom analys perform provid insight biolog process involv luad gimap expect prognost biomark luad provid potenti adjuv neoadjuv therapeut strategi target ici | D000077192;D002289;D019204;D008175 | T191;T126;T116 |
36,246,962 | phytochem analysi total phenol flavonoid content anticanc evalu solvent extract saponin h digitata cancer one challeng diseas modern era research investig extens research worldwid underway find novel therapeut prevent treatment diseas extract natur sourc shown one best effect treatment cell prolifer angiogenesi differ approach includ disc potato model brine shrimp chorioallanto membran cam assay adopt analyz anticanc effect habenaria digitata also evalu mtt activ niht cell line dexamethason etoposid vincristin sulfat use posit control assay extract includ crude extract hdcr saponin hdsp n hexan hdhx chloroform hdchf ethyl acet hdea aqueous fraction hdaq shown excel result use various assay exampl saponin chloroform display decent antitumor angiogen activ use potato tumor assay saponin fraction chloroform shown effici potato tumor experi demonstr tumor suppress concentr gml respect ic valu gml addit two sampl chloroform saponin outperform rest test sampl term antiangiogen activ ic gml gml respect character solvent fraction chloroform hdchf saponin hdsp appear display good effect tumor angiogenesi minim activ tumefacien hdchf hdsp prospect candid isol natur product antineoplast properti | D000970;D009369;D012503 | T121;T191;T109 |
36,246,961 | pyridin n oxid alkaloid allium stipitatum synthet disulfid analog potenti drug candid mycobacterium tuberculosi molecular dock qsbar admet predict approach studi consid pyridin n oxid alkaloid allium stipitatum synthet disulfid analog pdas candid next generat antimycobacteri agent light grow resist exist convent therapi silico studi involv molecular dock simul pdas carri mycobacterium tuberculosi target protein mts determin theoret bind affin compound b demonstr stronger bind affin similar mts molecular descriptor mds describ structur physicochem properti compound also calcul use chemd explor use pearson correl analysi princip compon analysi pca comparison mds convent antitubercular medicin pdas possess similar score isoniazid pyrazinamid mds also use conduct quantit structur bind affin relationship qsbar studi build good fit signific model princip compon regress pcr partial least squar regress plsr leav one cross valid adopt plsr result good predict model mts rang r rang q pcr plsr model predict signific effect ndonr hy mol wt nhev nring ndb log p w pol isiz tiac getov ui bind ligand mts silico predict pdas admet profil conduct qikprop util admet profil compound favor outcom current studi strengthen signific compound promis lead candid treatment multidrug resist tuberculosi | D000470;D000490;D009169 | T123;T121;T007;T109;T131;T002 |
36,246,960 | observ curat effect trimetazidin combin metoprolol elder patient coronari heart diseas complic heart failur effect myocardi remodel integr tradit chines western medicin diabet retinopathi dr common complic diabet often character damag retin vascular microcircul result retin exud hemorrhag fibrosi neovascular age countri popul incid dr increas year year becom one main blind eye diseas ophthalm diseas also tend younger far although pathogenesi dr complet clear scholar general believ dr base disord glucos metabol caus chang microcircul ocular tissu nerv blood vessel result chronic damag nutrit visual function eye diseas order explor demand cardiovascular diseas treatment make lack chronic diseas affect peopl physic harm improv success rate cardiovascular diseas treatment method observ efficaci myocardi remodel trimetazidin combin metoprolol elder patient coronari heart diseas heart failur base integr tradit chines western medicin propos elder peopl year old afraid cardiovascular diseas take activ protect method base observ integr tradit chines western medicin propos time intellig medic monitor system construct better studi observ improv efficaci trimetazidin combin metoprolol elder patient coronari heart diseas heart failur myocardi impact refactor result studi show trimetazidin good clinic effect ischem cardiomyopathi heart failur base observ integr tradit chines western medicin | D002318;D003327;D006333;D014292 | T121;T047;T046;T109 |
36,246,959 | clinic characterist risk factor among patient posit covid test admit icu studi show common characterist among icu admit patient due covid avail net studi saudi arabia limit | D000086382;D006973 | T047;T067 |
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