PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,246,462 | analysi correl colleg music educ public mental health base deep learn continu chang colleg music educ public mental health problem convent solut longer suffici time adopt method base deep learn studi experi show deep learn well integr two among rapport rate reach sometim unstabl state system solv optim model final evalu algorithm overal score model obtain fluctuat accord data figur tabl conclud univers music educ deep learn receiv attent countri invest amount also increas billion billion highest music educ activ univers becom concert music instrument experi class final countri public mental health problem becom countri lowest level world | D000077321;D009146 | T170;T066 |
36,246,461 | higher educ environ monitor qualiti assess model use big data analysi deep learn univers exist help student develop skill goal univers develop rais standard personnel train core compon univers develop teach qualiti whether level practic train soon meet requir enterpris employ respond demand profess occup essenti teach qualiti evalu crucial cornerston ensur qualiti instruct univers colleg therefor concentr evalu instruct school colleg rapid thorough comprehend campus cooper adult educ programm run also enhanc efficaci imparti qualiti assess utilis educ data mine learn analysi technolog current issu backward evalu instrument singl evalu topic easi evalu method exist evalu qualiti school big data technolog use creat higher vocat educ environ monitor qualiti evalu system offer new vari approach evalu teach qualiti techniqu evalu qualiti school expand upon research use various big data mine technolog improv collabor filter algorithm mean absolut differ approxim data set larger conclus appli big data set techniqu work perform greater accuraci convent collabor filter algorithm score matrix becom denser score item model turn result accur similar calcul begin programm albeit similar calcul error increas score matrix becom denser | D000078332;D000077321 | T066;T057 |
36,246,460 | person inform secur environ monitor law protect use big data analysi articl explor caus issu person data privaci outlin limit china current legal framework articl make argument inform age self disciplin legal protect combin order safeguard person inform safeti also make specif recommend strengthen legal protect research also develop data process platform data safeti privaci protect studi technolog data safeti environ monitor privaci protect work develop optim methodolog dynam privaci budget alloc increas model speed converg calibr generat data adjust various privaci timeli need assumpt object select match privat safeti satisfi accord experiment find algorithm accuraci reach method enhanc model speed converg calibr data creat address flaw present data fusion publish procedur withstand attack background inform studi find serv start point futur work data secur protect person inform | D016494;D000078332 | T078;T080;T170;T097;T057 |
36,246,459 | construct legal system corpor social respons base big data analysi technolog compani essenti organ modern societi compani transform pure econom organ corpor citizen realiz econom respons practic social respons time construct legal system corpor social respons compani take social respons track legal system realiz compani mission time achiev win win situat compani societi paper use lda text cluster method analyz exist legal text obtain theme text cluster result thus propos five aspect legal system construct framework guid corpor social respons legal system pioneer signific | D000078332;D012941 | T078;T054;T057 |
36,246,407 | liquid liquid phase separ promot protein aggreg implic ferroptosi parkinson diseas dementia patholog featur pdd repres dopaminerg neuron death intracellular synuclein syn aggreg interact iron accumul syn tau explor essenti patholog mechan pdd howev link mechan factor remain unclear studi shown occurr develop neurodegen diseas pdd close relat separ abnorm phase substanc protein form droplet liquid liquid phase separ llps normal physiolog condit even undergo liquid solid phase transit form solid aggreg diseas regulatori disord lead patholog phenomena analyz exist literatur propos llps crucial mechan caus abnorm accumul syn tau protein pdd interact iron metabol disord key factor drive ferroptosi pdd therefor believ llps serv one mean explain patholog mechan pdd determin signific llps neurodegen diseas pdd stimul interest research treatment base interfer abnorm llps | D000544;D003704;D000079403;D019636;D010300 | T047;T043;T048 |
36,246,406 | macrophag differenti mediat gene ddx molecular biomark encompass tumor microenviron diseas stage prognos hepatocellular carcinoma ddx involv mechan cell prolifer mitogen et transcript suppressor met arrest cell cycl macrophag howev littl known ddx express clinic valu relationship tumor microenviron hcc | D006528;D008113;D035683 | T123;T191;T114 |
36,246,405 | cancer cell membran biomimet mesopor nanozym system effici ros generat antitumor chemoresist singl atom nanozym saz reaction specif optim catalyt properti great applic prospect tumor therapi complex tumor microenviron low content h limit therapeut effect studi develop bionic mesopor fe sazsddp nanosystem csd enhanc nanocatalyt therapi nct chemotherapi simultan encapsul chemotherapeut drug cisplatin ddp fe saz high peroxidas pod activ cancer cell membran csd could evad immun recognit activ target tumor site ddp upregul endogen h level activ nicotinamid adenin dinucleotid phosphat nadph oxidas therebi enhanc saz mediat hydroxyl radic oh product subsequ lead mitochondri damag intoler chemotherapi drug use hgcddp cell line vitro vivo experi result show csd achiev good therapeut benefit without side effect inflammatori reaction system induc multipl antitumor effect h self suppli mitochondri damag atp downregul eventu lead chemosensit | D002945;D009369 | T121;T197;T191 |
36,246,404 | cancer associ fibroblast hinder lung squamous cell carcinoma oxid stress induc apoptosi via mettl mediat methyl cola cancer associ fibroblast caf within tumor microenviron key player tumorigenesi tumor develop nevertheless regulatori mechan caf lung squamous cell carcinoma lusc associ remain poor elucid | D000072645;D002289;D002294;D008175 | T191;T025 |
36,246,403 | relat angiogen gene construct prognost signatur reveal immun oxid stress landscap screen drug hepatocellular carcinoma modif play key role develop hepatocellular carcinoma hcc angiogenesi relat gene arg increas use defin signatur predict patient prognosi correl relat arg marg clinic outcom immun oxid stress landscap unclear | D006528;D008113 | T191 |
36,246,402 | bio function potenti biochem properti propoli collect differ region balochistan provinc pakistan propoli well known resin natur substanc collect honeybe api mellifera l plant exud variat chemic composit propoli due differ sourc collect chang climat geograph locat studi differ propoli sampl collect differ region balochistan examin chemic composit total phenol total flavonoid content antioxid potenti use dpph radic scaveng assay antimicrobi activ bioactiv compon analysi reveal presenc steroid carbohydr flavonoid coumarin cardiac glycosid quinon anthraquinon terpenoid tannin phlobatannin differ level total phenol content rang mg gae g flavonoid content found mg qe g respect antioxid abil extract analyz concentr inhibit ic propoli sampl p possess lower ic mg ml higher inhibit dpph radic p show lower inhibit ic mg ml antibacteri activ sampl analyz wide group bacteria includ escherichia coli staphylococcus aureus pseudomona aeruginosa klebsiella pneumonia propoli extract p high activ klebsiella pneumonia maximum diamet zone inhibit mm propoli extract p show maximum zone inhibit escherichia coli propoli extract p found less activ minimum diamet zone inhibit mm antifung activ extract consid activ fungal speci propoli extract p show zone inhibit aspergillus niger propoli extract p high activ aspergillus parasiticus zone inhibit compar vibrat frequenc wave number sampl spectrograph acquir ftir spectrophotomet function group present extract identifi presenc seven element fe zn mn ni pb cd cr analyz atom absorpt spectrophotomet obtain concentr within permiss rang establish world health organ gc ms analysi reveal presenc differ compound belong differ class obtain result confirm imper potenti propoli use various biolog applic | D002301;D011429 | T121;T123;T109 |
36,246,401 | oxid stress fibromyalgia patholog treatment fibromyalgia fm character chronic widespread musculoskelet pain associ sleep problem fatigu depress anxieti persist pain impair cognit function negat impact psycholog state caus detriment effect patient qualiti life howev date treatment mechan diseas yet establish oxid stress might play critic role fm pathophysiolog increas level prooxid factor nitric oxid lipid peroxid mitophagi caus pain sensit fibromyalgia numer studi support hypothesi benefici antioxid effect fm due lack effect therapi fibromyalgia mani treatment sought reduc pain fatigu improv patient qualiti life manuscript discuss impact various antioxid procedur diminish fibromyalgia symptom hyperbar oxygen therapi modif dietari habit physic activ | D005356 | T047 |
36,246,400 | relationship ferroptosi pyroptosi relat gene clinic prognosi tumor immun microenviron head neck squamous cell carcinoma ferroptosi pyroptosi two new program cell death pcd mode discov recent year howev potenti valu ferroptosi pyroptosi relat gene fprgs prognosi predict tumor immun microenviron head neck squamous cell carcinoma hnscc still unclear obtain signific fprgs base train dataset tcga hnsc use univari cox differenti express analysi tcga hnsc n dataset cluster two group cluster b base signific fprgs differenti express gene deg cluster b put univari cox least absolut shrinkag select oper lasso analysi build risk model predict capabl risk model success confirm intern valid extern valid clinic sampl valid improv clinic applic nomogram model combin risk score clinic inform construct moreov patient lower risk score character increas immun respons tumor mutat burden tmb patient higher risk score character increas tp mutat rate conclus comprehens analysi fprgs reveal signific role prognosi predict tumor immun microenviron risk model contain fprgs could potenti prognost marker effect immunotherapi target hnscc | D000079403;D006258 | T191;T043 |
36,246,399 | current insight bioactiv molecul antioxid anti inflammatori pharmacolog activ cinnamomum camphora linn c camphora renown tradit unani medicin herb belong famili lauracea therapeut applic various ailment prophylact properti prevent flu like epidem symptom covid comprehens apprais familiar reader tradit broad applic camphor unani modern medicin effect bioactiv molecul electron databas web scienc pubm googl scholar scopus research gate search bioactiv molecul preclinicalclin research includ research review paper retriev addit classic unani english herbal pharmacopeia book ethnomedicin properti therapeut applic explor oxid stress signific impact age obes diabet mellitus depress neurodegen diseas polyphenol bioactiv compound linalool borneol nerolidol c camphora antioxid activ potenti remov free radic major bioactiv molecul camphor cineol limelol safrol limonen alpha pinen cineol anti inflammatori antibacteri anxiolyt analges immunomodulatori antihyperlipidem mani pharmacolog properti establish vitro vivo preclin research natur bioactiv molecul mechan action applic diseas highlight futur prospect gap prioriti need address | D014151;D000086382;D027423 | T121;T067;T039;T002;T047 |
36,246,398 | pcaf acceler vascular senesc via hippo signal pathway pcbp associ factor pcaf one histon acetyltransferas hat known involv cell growth andor differenti pcaf report involv atherosclerot plaqu neointim format howev role cellular senesc remain undefin investig potenti mechan pcaf mediat cellular senesc immunohistochem ihc analysi show pcaf distinct increas endothelia aorta age mice palmit acid pa x radiat signific induc express senesc associ marker pcaf human umbil vein endotheli cell huvec pcaf silenc pa treat huvec signific rescu senesc associ phenotyp pcaf overexpress acceler addit result show yes associ transcript regul yap act end effector hippo signal pathway crucial pcaf mediat endotheli senesc yap activ declin observ age vascular endothelia overexpress yap partial amelior pcaf induc endotheli senesc vivo endotheli ec specif pcaf downregul age mice use adeno associ virus reveal less vascular senesc associ phenotyp result suggest pcaf mediat endotheli senesc hippo signal pathway impli pcaf may becom potenti target prevent treatment vascular age | D042783;D000090683 | T025;T043 |
36,246,397 | potenti role voltag depend anion channel treatment parkinson diseas parkinson diseas pd neurodegen diseas second alzheim diseas term preval previous studi indic occurr progress pd associ mitochondri dysfunct mitochondri dysfunct one import caus apoptosi dopaminerg neuron therefor maintain stabil mitochondri function potenti strategi treatment pd voltag depend anion channel vdac main compon outer mitochondri membran particip varieti biolog process review focus potenti role vdac treatment pd found vdac involv pd regul apoptosi autophagi ferroptosi vdac oligomer vdac ubiquitin regul mitochondri permeabl transit pore mptp vdac interact vdac synuclein syn promis method treatment pd propos inhibit vdac oligomer promot vdac ubiquitin effect approach treatment pd previous studi proven express vdac signific chang pd model express level vdac decreas substantia nigra sn patient suffer pd compar control group consist normal individu use bioinformat tool vdac involv pd main regul apoptosi vdac may similar function vdac conclud function role vdac contribut therapeut strategi pd | D019636;D010300 | T047 |
36,246,396 | effect lycopen attenu injuri ischemia reperfus tissu organ ischemia lead cell trauma tissu necrosi irrevers damag death intend revers ischemia reperfus aggrav ischem injuri ischemia reperfus injuri ir injuri rang patholog process ir injuri one organ also harm organ lead system multiorgan failur type carotenoid lycopen shown treat prevent mani diseas eg rheumatoid arthriti cancer diabet osteoporosi male infertil neurodegen diseas cardiovascular diseas make hot research topic health care recent research suggest lycopen evid amelior ischem ir injuri mani organ clinic studi avail therefor essenti review effect lycopen ischem ir injuri differ organ may help research potenti clinic applic | D000975;D015427 | T123;T121;T037;T039;T044 |
36,246,395 | energi stress mediat ampk activ promot gpx depend ferroptosi jakstatp axi renal cancer energi stress unfavor condit tumor cell often expos ferroptosi consid emerg target tumor therapi howev role ferroptosi energi stress renal cancer current unknown studi found glucos depriv signific enhanc gpx depend ferroptosi ampk activ ampk activ suppress gpx express transcript level upregul p express addit inactiv jakstat transcript promot p express therebi promot ampk mediat gpx depend ferroptosi conclus energi stress promot ampk mediat gpx depend erastin induc ferroptosi renal cancer jakstatp signal axi | D000079403;D007680 | T191;T043 |
36,245,845 | effect enter parenter nutrit support pulmonari function elder patient chronic obstruct pulmonari diseas complic respiratori failur investig effect enter parenter nutrit support epn pulmonari function elder patient chronic obstruct pulmonari diseas copd complic respiratori failur rf | D029424;D012131 | T047;T046 |
36,245,844 | construct prognost risk model small cell lung cancer base immun relat gene small cell lung cancer sclc high invas fatal malign research present stage impli express immun relat gene associ prognosi sclc accord essenti explor effect immun relat molecular marker judg prognosi treat sclc research obtain sclc dataset gene express omnibus geo subject mrnas differenti express analysi differenti express mrnas demrna intersect immun relat gene yield immun relat differenti express gene deg function deg reveal gene ontolog go kyoto encyclopedia gene genom kegg enrich analys thereaft categor subtyp immun relat deg via k mean cluster kaplan meier curv analyz effect subtyp sclc patient surviv singl sampl gene set enrich analysi ssgsea estim valid activ differ immun gene subtyp differ signific final immun relat gene assess model construct univari lasso multipl cox regress analys riskscor kaplan meier curv receiv oper characterist roc curv independ prognost analys valid prognost valu immun relat gene assess model suggest gsea promin differ cytokin relat pathway high low risk group analysi went discov statist signific differ express human leukocyt antigen hla protein costimulatori molecul express surfac cd cd lymphocyt differ group word start immun relat gene construct prognost model sclc could effect evalu clinic outcom offer guidanc treatment prognosi sclc patient | D008175;D055752 | T191 |
36,245,843 | identif key gene involv tumorigenesi prognosi prostat cancer prostat cancer pca malign tumor male major case advanc metastat castrat resist metastasi lead caus mortal pca tradit earli detect predict approach differenti differ stage pca therefor new biomark necessari earli detect clear differenti pca stage provid precis therapeut intervent | D011471;D011944 | T191;T116;T192 |
36,245,842 | high express adher circul integrin serv diagnost marker venous thromboembol investig diagnost valu circul integrin venous thrombosi vte | D016023;D054556 | T047;T192;T116;T129 |
36,245,841 | associ waist circumfer preval surviv digest tract cancer us adult popul studi base machin learn method paper aim investig relationship waist circumfer wc digest tract cancer morbid mortal | D000069550;D009369 | T191;T066 |
36,245,840 | studi antidepress emot regul base feedback analysi music therapi brain comput interfac today societi peopl poor mental abil prone neuropsychiatr diseas anxieti adhd depress due long term negat emot although convent western medicin certain curat effect drug signific anticholinerg side effect central toxic well cardiovascular gastrointestin side effect limit applic elder present sever antidepress use clinic certain limit accord symptom depress paper propos feedback emot regul method brain comput interfac music therapi method use special music stimul regul releas inhibit sex hormon bodi reduc influenc negat emot intern environ bodi maintain steadi state bodi method eeg use emot control signal depress patient biolog signal transform music depress patient understand clarifi physiolog psycholog state realiz emot self regul feedback | D062207;D000080103;D009146;D009147 | T061;T074;T170;T041 |
36,245,839 | stretch train rehabilit potenti allevi ankylos spondyl mice inactiv wnt catenin pathway ankylos spondyl chronic inflammatori diseas character invas joint central axi involv soft tissu joint surround spine stretch train rehabilit str wide appli treatment wnt catenin signal pathway close relat studi aim explor potenti molecular mechan under protect effect str vitro vivo male dba mice employ establish anim model hematoxylin eosin stain show str revers patholog damag bone tissu total antioxid capac mice increas antioxid capac upregul superoxid dismutas malondialdehyd express dba mice mtt rt qpcr western blot result indic str improv surviv rate cell downregul express target gene wnt catenin pathway inhibit cell inflamm apoptosi conclus find indic str treatment might effect therapeut strategi | D013167;D051176 | T047;T123;T116 |
36,245,838 | identif novel gene marker base gene profil among differ sever obstruct sleep apnea obstruct sleep apnea osa caus repeat blockag upper respiratori airway sleep tradit evalu method osa sever yet limit studi aim screen gene signatur effect evalu osa sever express profil peripher blood mononuclear cell differ sever osa patient access gene express omnibus geo databas total differenti express gene deg screen among vari sever osa sampl analysi varianc anova test total deg screen pre post treatment osa sampl use test overlap two group deg select deg metascap enrich analysi afterward mfuzz packag use perform soft cluster analysi gene cluster obtain observ gene express condit cluster posit associ osa sever degre also gene express condit cluster negat correl osa sever total gene marker relat osa progress select cluster cluster express level correl analyz marker gene cluster cluster examin find gene signific correl apnea hypopnea index ahi accur object assess sever osa great signific formul follow treatment strategi patient osa paper set marker gene detect sever osa screen bioinformat method could joint use tradit osa diagnost index achiev reliabl osa sever evalu | D007963;D020181 | T025;T047 |
36,245,837 | classif method thoracolumbar vertebr fractur due basketbal sport injuri base deep learn basketbal competit propos classif method thoracolumbar fractur assist diagnosi basketbal injuri analyz feasibl clinic applic improv recoveri rate | D001265;D001490;D000077321;D050723;D016103 | T056;T066;T073;T037 |
36,245,836 | mha net multibranch hybrid attent network medic imag segment robust segment organ medic imag key techniqu medic imag analysi diseas diagnosi u net robust structur medic imag segment howev u net adopt consecut downsampl encod captur multiscal featur result loss contextu inform insuffici recoveri high level semant featur paper present new multibranch hybrid attent network mha net captur contextu inform high level semant featur main idea propos mha net use multibranch hybrid attent featur decod recov high level semant featur lightweight pyramid split attent psa modul use connect encod decod subnetwork obtain richer multiscal featur map compar propos mha net state art approach drive dataset fluoroscop roentgenograph stereophotogrammetr analysi x ray dataset polyp dataset experiment result differ modal imag reveal propos mha net provid better segment result segment approach | D007091;D016571 | T170;T066 |
36,245,835 | clinic effect catgut embed plus warm needl moxibust improv inflamm qualiti life knee osteoarthr patient clarifi influenc catgut embed plus warm needl moxibust improv inflamm qualiti life knee osteoarthr patient | D009071;D020370 | T061;T047 |
36,245,667 | post traumat stress disord post traumat growth follow kidney transplant kidney transplant kt life save therapi kidney failur howev kt recipi suffer debilit depress post traumat stress disord ptsd suicid contrast ptsd post traumat growth ptg posit psycholog chang respons challeng situat ptg studi chronic diseas less known role set kt sought elucid preval predictor effect ptsd ptg post kt outcom also consid role benefit find resili | D016030;D000078002;D013313 | T061;T041;T048 |
36,245,665 | machin learn model predict mortal within day dialysi initi first day dialysi initi associ high morbid mortal end stage kidney diseas eskd patient machin learn base tool predict mortal could inform patient clinician share decis make whether initi dialysi pursu medic manag use extrem gradient boost xgboost algorithm predict mortal first day dialysi initi nation repres popul unit state renal data system | D007676;D000069550;D015233;D006435 | T047;T061;T066;T081;T170 |
36,245,664 | gut kidney crosstalk immunoglobulin nephropathi immunoglobulin nephropathi igan common primari glomerulonephr worldwid work model pathogenesi igan involv multistep process start product galactos defici polymer immunoglobulin gd iga enter system circul gut associ lymphoid tissu galt galactos defici iga target endogen igg lead format circul immun complex deposit mesangium result glomerular inflamm diseas onset relaps often associ gut infect support hypothesi gut play import pathogen role presenc microbi pathogen food antigen activ dendrit cell gut mucosa induc cell depend independ b cell differenti iga secret plasma cell igan patient promot system releas mucos gd iga bacteri strain capac elicit iga product littl known antigen specif pathogen gd iga howev efficaci treatment target gut inflamm support pathogen link bowel immun system igan herein review evid support role gut inflamm igan pathogenesi | D005922 | T047 |
36,245,663 | urinari neutrophil gelatinas associ lipocalin predict intens care unit admiss diagnosi prospect cohort studi acut kidney injuri aki common caus tubular injuri associ wide varieti critic ill well known urinari biomark lead earli identif aki howev abil urinari biomark distinguish differ type critic ill less studi | D058186;D054834 | T047;T123;T116;T037 |
36,245,662 | practic guid genet test kidney disord unknown etiolog genet test increas use workup diagnosi kidney diseas kidney relat disord undetermin caus pocket cost clinic genet test becom afford logist hurdl overcom interest genet test may stem need make confirm diagnosi guid manag patient desir inform explan prognosi pose challeng provid formal train select interpret limit genet test manuscript provid detail discuss relev case clinic genet test use kidney gene panel appli case demonstr identif pathogen variant monogen diseas contrast genet risk allel bring diagnost limit diagnost util test nephrolog review aim guid clinician formul pretest convers patient interpret genet variant nomenclatur consid follow investig although provid gain experi still risk test caus anxieti benefit howev provid educ support clinic genet test appli otherwis unexplain kidney relat disord increas serv valuabl diagnost tool potenti reshap consid treat mani kidney relat diagnos | D007674;D009398 | T047;T091 |
36,245,660 | develop administr data base frailti index older adult receiv dialysi frailti present older adult receiv dialysi object develop administr data base frailti index assess frailti index predict valid mortal futur hospit | D000073496 | T046;T184;T033 |
36,245,654 | critic role osteopontin maintain urinari phosphat solubl ckd nephron loss dramat increas tubular phosphat concentr exceed supersatur osteopontin opn matricellular protein enhanc miner solubl solut howev role opn maintain urinari phosphat solubl ckd remain undefin | D009397;D051436 | T047 |
36,245,653 | develop new equat predict mortal risk patient continu rrt predict risk death patient admit critic care unit facilit appropri manag particular among patient critic ill patient continu rrt crrt high mortal predict mortal risk patient difficult purpos studi develop model predict mortal risk patient crrt valid model extern | D000079664 | T061 |
36,245,651 | post hoc analysi kidneyintelx cardioren outcom diabet kidney diseas kidneyintelx bioprognost test assess risk ckd progress risk stratifi individu kidney heart failur death outcom canagliflozin cardiovascular assess studyindividu score high risk seem deriv benefit treatment canagliflozin versus placebothes find may serv increas adopt underutil therapi cardioren risk reduct patient diabet kidney diseas | D002319;D003924;D003928;D000077203 | T022;T047;T109;T121 |
36,245,649 | continu long term physic activ monitor hemodialysi patient physic inact common patient receiv hemodialysi activ pattern throughout day relat dialysi larg unknown knowledg gap address long term continu activ monitor attempt may accept patient receiv dialysi | D000072936;D007676;D018670;D006435 | T061;T047;T060;T073 |
36,245,648 | integr diabet eye screen hemodialysi unit northern ireland diabet rise global common caus end stage renal diseas blind peopl hemodialysi attend sever dialysi appoint per week affect attend diabet eye screen addit previous literatur suggest patient hemodialysi like sight threaten diabet eye diseas studi aim determin attend diabet eye screen program northern ireland diabet retinopathi sever use handheld retin imag peopl diabet attend hemodialysi unit northern ireland | D003920;D003930 | T047 |
36,245,647 | chang iron avail roxadustat nondialysi dialysi depend patient anemia ckd roxadustat hypoxia induc factor prolyl hydroxylas inhibitor increas hemoglobin stimul erythropoietin synthesi improv iron avail facilit iron uptak andor releas store exploratori analysi assess effect roxadustat treatment laboratori paramet relat iron metabol patient anemia chronic kidney diseas ckd | D000740;D004921;D064800;D051436 | T121;T047;T116;T125 |
36,245,645 | dendrit cell epitheli sodium channel inflamm salt sensit hypertens kidney damag salt sensit hypertens major risk factor cardiovascular morbid mortal pathophysiolog mechan lead differ individu bp respons chang dietari salt remain elus research last two decad reveal immun system play critic role develop hypertens relat end organ damag moreov sodium accumul nonosmot human tissu includ skin muscl shift dogma bodi sodium balanc regul emerg evid suggest high concentr extracellular sodium direct trigger inflammatori respons antigen present cell apc lead hypertens vascular renal injuri import sodium entri apc mediat epitheli sodium channel enac although role enac renal regul sodium excret bp well establish new find impli enac may also exert bp modulatori effect extraren tissu immun depend pathway review discuss recent advanc understand pathophysiolog salt sensit hypertens particular focus role apc extraren enac | D006973;D017673 | T047;T168 |
36,245,643 | fgf cardiovascular structur function advanc chronic kidney diseas fibroblast growth factor fgf bone deriv phosphatonin elev chronic kidney diseas ckd implic develop cardiovascular diseas unknown whether elev fgf ckd associ impair cardiovascular function capac assess maximum exercis oxygen consumpt vo max sought determin whether fgf associ cardiovascular function capac patient advanc ckd improv vo max kidney transplant | D007676;D016030;D051436 | T061;T047 |
36,245,556 | integr multi omic analysi base nomogram predict prostat cancer bone metastasi incid common site prostat cancer metastasi bone tissu mani recent studi conduct genom clinic research regard bone metastat prostat cancer howev work need better defin patient elev risk metastasi | D001859;D035683;D011471;D062085 | T191;T123;T114 |
36,245,555 | effect genet variant nicotin metabol pathway smoke cessat aim investig associ various genet variant nicotin metabol pathway smoke cessat sc chines han popul | D016540 | T055 |
36,245,431 | risk somat diseas patient eat disord role comorbid substanc use disord eat disord ed substanc use disord sud often co occur involv somat diseas far studi consid whether comorbid sud may impact somat diseas risk patient ed therefor studi aim examin impact comorbid sud risk somat diseas categori patient anorexia nervosa bulimia nervosa bn unspecifi eat disord use compar match control | D001068;D019966 | T047;T048;T033 |
36,245,426 | long non code rna vpsd enhanc prolifer invas epitheli mesenchym transit endometri cancer via mir psgk endometri cancer ec kind gynecolog malign rise incid rate studi aim explor role vpsd antisens rna vpsd ec express vpsd microrna mir p serum glucocorticoid regul kinas sgk detect quantit real time pcr qrt pcr cell prolifer invas epitheli mesenchym transit emt determin cell count kit cck ethynyl deoxyuridin edu transwel western bolt vpsd predict spong mir p via starbas verifi luciferas report rna bind protein immunoprecipit rip rna pull experi clinic characterist vpsd mir p sgk analyz role vpsd ec tumorigenesi assess xenograft nude mice vpsd upregul ec cell tissu interfer vpsd inhibit growth invas emt ec cell mechan vpsd molecular spong mir p overexpress mir p revers vpsd induc ec cell prolifer invas emt moreov sgk confirm bind mir p furthermor overexpress sgk allevi sh vpsd caus effect ec cell high level vpsd sgk low mir p express predict poor prognosi express three gene correl lymph node metastasi patholog stage intern feder gynecolog obstetr figo stage associ age er pr express interest knockdown vpsd suppress ec tumor growth mice vpsd promot cell invas prolifer emt via modul mir psgk axi provid new option therapeut strategi ec | D062085;D035683;D016889 | T191;T123;T114 |
36,245,424 | preval anxieti depress peopl differ type cancer haematolog malign cross section studi cancer patient often present psycholog symptom affect qualiti life physic health outcom surviv two frequent psychiatr comorbid anxieti depress howev preval disord among cancer patient remain unclear studi frequent report vari rate present studi aim provid robust point estim preval anxieti depress mix cancer sampl cancer type separ consid confound variabl | D001932;D001943;D019337 | T191 |
36,245,422 | orang fluoresc carbon dot employ quantit analysi silver ion glyphosin mode success develop kind carbon dot cd emit obvious orang fluoresc base hydrotherm method polyacryl acid employ carbon sourc develop cds equip multipl function group co oh cooh facilit possibl interact potenti target meaning introduct silver ion induc fluoresc quench prepar cds meanwhil propos cds achiev detect ag linear rang detect limit moreov addit glyphosin gradual recov fluoresc accompani concentr glyphosin vari detect limit therebi cds prepar show potenti broaden avenu detect ag glyphosin | D045663;D032084;D010575 | T131;T168;T073;T002 |
36,245,417 | preval prevent suicid ideat among asylum seeker high risk urban post displac set among asylum seeker high risk unstabl post displac context aim investig preval risk suicid ideat studi test whether mind base trauma recoveri refuge mbtr r may prevent treat suicid ideat studi | D012036;D013313 | T098;T048 |
36,245,410 | public health public good toward univers wellb aim consolid recent trend public health reconceptu field public good build sever strand theori research action formul impact futur field argument compris three main part first part describ central compon propos public good condit justic experi matter outcom subject object wellb second section identifi continua practic paint trajectori tradit public health ecolog participatori public health univers wellb frame public good continua defin term assumpt practic role among other continua pertain capabl scope field ecolog focus time intervent role citizen role profession role set role govern final third section introduc seri strategi recommend make narrat univers wellb public good realiti | D011634;D012935 | T078;T091;T080 |
36,245,409 | evid public health integr multidisciplinari concept tradit evid public health found health scienc use hierarchi evid commentari argu need combin evid base broad rang scientif disciplin methodolog best translat research improv public health | D011634 | T091 |
36,245,408 | norwegian polici reduc social inequ health develop reduc social inequ health import aim develop nordic welfar state commentari present develop norwegian polici area social inequ enter polit agenda norway most defin problem select marginalis group world health organ project led michael marmot inspir norwegian polici maker concept social gradient introduc level social gradient health becam central strategi norwegian polici make culmin public health act act focus structur determin health municip central role implement howev municip most respons servic provid downstream measur littl control social determin tax labour market polici public health act import institutionalis social inequ polici field within public health municip administr level contribut meet aim reduc social gradient | D006291;D054624 | T089;T080 |
36,245,407 | examin public health impact function somat disord use danfund studi background persist physic symptom eg pain fatigu preval popul person may develop function somat disord fsd still need explor limit general bodili sensat fsd great controversi exist regard delimit occurr risk factor prognosi cost fsd general popul main due lack focus suffici power popul base epidemiolog studi materi method danfund studi largest focus popul base studi fsd potenti answer crucial question regard fsd disord danfund origin copenhagen area denmark initi interdisciplinari team research includ basic scientist clinic research epidemiologist public health research popul base cohort near peopl fill detail questionnair gone thorough health examin biobank establish cohort examin five year result preval fsd danish popul twice common women men person fsd report impair daili activ low self perceiv health qualifi fsd major public health problem research plan unravel risk factor fsd employ bio psycho social approach accord detail plan preliminari result present work progress likewis plan assess prognosi health care cost provid conclus invit research field collabor uniqu data materi | D011634;D013001 | T091;T048 |
36,245,406 | popul base epidemiolog glostrup popul studi glostrup popul studi popul base cohort undertaken south western part greater copenhagen sinc particip random select adult general popul first cohort establish assess cardiovascular risk factor sinc object broaden describ analys health general popul studi health examin studi clinic biochem data addit data self administ questionnair studi interview fast blood urin sampl collect store biobank studi sever cohort perform accord standard method intern consortia henc data pool danish intern cohort date individu men women age year particip glostrup popul studi particip examin eight time data use diseas specif epidemiolog social epidemiolog genet epidemiolog age lifestyl health intervent nest within cohort glostrup popul studi repres great resourc possibl merg differ cohort enabl larg dataset well trend time furthermor long follow nation regist follow examin uniqu purpos commentari inform glostrup popul studi invit collabor continu util great resourc combat current futur challeng within health promot diseas prevent | D000375;D012107 | T081;T170;T040;T169;T062;T096;T033 |
36,245,405 | migrat health research nordic countri prioriti implic public health past year wit increas immigr nordic countri beyond neighbour countri europ divers impli variat differ health status health outcom within across popul migrant health research priorit health polici practic especi long term nation plan often exclud migrant articl briefli trace histori group reason migrat road migrant health research norway sweden finland denmark discuss case data research includ need basi data collect methodolog challeng provid brief snapshot migrant health research identifi current gap discuss implic research recommend region nordic strategi promot intercountri exchang share learn final reflect larger pictur implic polici practic could enabl societ condit reduc avoid health inequ | D011634;D014171 | T098;T091 |
36,245,404 | improv health adolesc nordic countri help fill evid gap nordic countri well develop welfar polici sever structur statutori measur place aim promot public health studi countri often absent systemat review research literatur assess effect polici measur design promot health use adolesc health promot effort relat primari prevent obes exampl short commentari aim illustr pauciti well design studi investig effect public health polici affect adolesc paper argu nordic research communiti good posit help fill gap contribut wide intern literatur evalu polici intervent | D006293;D011634 | T091;T058;T170 |
36,245,402 | advers childhood experi global mental health avenu reduc burden child adolesc mental disord mental disord one largest contributor burden diseas global hold also children adolesc especi low middl incom countri preval sever disord influenc social determin includ exposur advers occur earli life latter event refer advers childhood experi ace editori provid overview literatur role ace social determin mental health lens global mental health relat ace mental health extens explor research centr higher incom context argu find realm global mental health integr ace eg prevent respons psychosoci intervent children adolesc caregiv field global mental health also undertak activ effort better address ace initi goal reduc burden mental disord among children adolesc global | D000076783;D001523 | T048;T033 |
36,245,364 | molybdenum carbid base photocatalyst synthesi function applic effect non nobl molybdenum carbid mo x c moc mo c attract extens attent regard promis research area near futur owe good biocompat high stabil band gap adjust rich valenc state excel catalyt activ perspect summar recent progress achiev molybdenum carbid base catalyst first crystal band structur molybdenum carbid general present second various modifi strategi molybdenum carbid outlin enhanc photocatalyt perform includ dope engin vacanc engin morpholog structur engin establish molybdenum carbid base composit catalyst final potenti applic photocatalysi area molybdenum carbid base photocatalyst general futur develop trend perspect promis materi also discuss | D008982 | T123;T196 |
36,245,358 | applic parallel laser apparatus measur forearm flang wild bornean orangutan pongo pygmaeus wurmbii construct parallel laser photogrammetri apparatus construct commerci avail part measur forearm length flang width wild bornean orangutan object valid method apparatus discuss issu encount construct preliminari growth curv adult male also compar flang width forearm length way investig relationship bodi size flang develop use camera cage around dslr camera top attach two parallel green laser estim error repeat accuraci interobserv reliabl measur measur forearm length three differ way see consist longest forearm measur repeat cv similar flang repeat accuraci measur known object high error interobserv discrep low laser space increas distanc subject correct use calibr photo session transpar discuss issu encount aim access method help expand use laser photogrammetri preliminari measur show male flang width forearm length reliabl increas tandem femal growth plateaus around age first birth year old conclud suggest improv apparatus method ensur laser remain parallel | D011148;D005542 | T015;T023 |
36,245,335 | contribut phylogenet understand evolut epidemiolog dengu virus dengu virus denv one import arbovir pathogen tropic subtrop near one third world popul risk infect transmiss denv involv sylvat cycl nonhuman primat nhp aed genus mosquito endem cycl human host predomin aed aegypti denv belong genus flavivirus famili flavivirida consist four antigen distinct serotyp denv phylogenet analys denv reveal origin epidemiolog driver determin molecular evolut natur review discuss phylogenet research improv understand denv evolut affect viral ecolog improv abil analyz predict futur denv emerg | D003716;D003715;D000330 | T047;T005;T204 |
36,245,324 | singl cell rna sequenc technolog demonstr heterogen age prostat peripher transit zone identifi cellular function heterogen within age prostat critic understand spatial distribut prostat diseas | D000728;D011467 | T121;T023;T125;T039 |
36,245,297 | csf glial marker elev subset patient genet frontotempor dementia neuroinflamm shown import pathophysiolog diseas mechan frontotempor dementia ftd includ activ microglia process measur life assay differ glia deriv biomark cerebrospin fluid howev studi far taken place ftd even fewer focus genet form ftd | D057180;D020774 | T047;T048 |
36,245,291 | emerg role ib inflamm emphasi psoriasi psoriasi chronic inflammatori disord affect skin joint result immunolog dysfunct enhanc il induc th differenti ikappab zeta ib atyp transcript factor ib protein famili sinc contrari famili member posit regul nf b pathway exclus local nucleus ib defici reduc visibl manifest experiment psoriasi diminish express psoriasi associ gene thus tempt consid ib potenti therapeut target psoriasi well ilil mediat inflammatori diseas review discuss regul express nfkbiz protein ib downstream target involv pathogenesi multipl disord emphasi psoriasi evid support inhibit ib may promis altern current therapeut manag psoriasi | D016328;D011565 | T047;T116;T129 |
36,245,289 | prognost valu molecular properti tertiari lymphoid structur oesophag squamous cell carcinoma tertiari lymphoid structur tlss play key role tumour adapt immun howev prognost valu molecular properti tlss oesophag squamous cell carcinoma escc patient studi | D004938;D000077277;D000072717 | T191;T024 |
36,245,253 | singl cell transcriptom profil reveal key role znf natur killer cell exhaust multipl myeloma decreas cytotox natur killer nk cell shown multipl myeloma mm howev under molecular mechan remain unclear use singl cell rna sequenc analysi vitro experi aim uncov valid molecular distinct insight identifi regul nk cell exhaust provid potenti target novel immun therapi mm | D009101 | T191 |
36,245,248 | revisit antiangiogen multikinas inhibitor era immun checkpoint blockad case sorafenib success develop multikinas inhibitor last two decad revolution manag mani malign cancer agent antiangiogen kinas inhibitor sorafenib certain advantag broad spectrum activ cancer cell vascular endotheli cell pericyt mainstay treatment diseas advanc renal liver cancer recent emerg immunotherapi use immun checkpoint blockad diseas rais import question treatment interact antiangiogen drug seven combin approv lung liver kidney endometri cancer multipl combin therapi aggress pursu clinic thus reveal mechan action antiangiogen kinas inhibitor combin immun checkpoint blockad critic improv treatment outcom landmark commentari sorafenib cancer therapi highlight import question see relat articl wilhelm et al cancer res | D000082082;D008113 | T121;T191;T043;T129 |
36,245,247 | dawn antibodi drug conjug era dm reinvent futur chemotherapi solid tumor deliv target chemotherapi antibodi drug conjug adc emerg extrem effect therapeut strategi multipl type cancer first agent class establish treat solid tumor trastuzumab emtansin dm approv treatment posit metastat breast cancer much knowledg led approv came landmark cancer research public lewi phillip colleagu describ vitro vivo efficaci pharmacokinet toxic dm demonstr relev preclin activ posit breast cancer model articl author also explor use differ linker conjug cytotox payload trastuzumab vehicl demonstr improv stabil efficaci toler compound adopt specif thioether linker find work set stage clinic develop dm also highlight modular adc small chang compon abl dramat impact activ toxic find would prove key develop novel adc sever reshap way treat breast cancer cancer type commentari discuss key implic work phillip colleagu put context current anticip expans use adc treat cancer see relat articl phillip et al cancer res | D000970;D001943;D018796;D008453 | T121;T129;T109;T191 |
36,245,246 | uniqu foxa associ chromatin state dictat therapeut resist lobular breast cancer invas lobular carcinoma ilc second common histolog subtyp breast cancer account case ilc estrogen receptor er posit yet biolog distinct invas ductal carcinoma idc retrospect analys indic poorer outcom endocrin therapi issu cancer research nardon colleagu investig mechan differenti therapi respons ilc sole explain genet profil tumor author conduct thorough examin epigenom ilc compar idc clinic preclin model reveal altern chromatin access state ilc driven pioneer factor foxa foxa regul express feed forward mechan bind ilc uniqu foxa enhanc site result foxa er axi promot transcript gene associ tumor progress tamoxifen resist target foxa enhanc region block transcript program inhibit ilc prolifer result shed light new epigenet mechan drive ilc tumor progress treatment resist may profound therapeut implic see relat articl nardon et al p | D001943;D018270;D018275 | T191 |
36,245,245 | detour experi recommend lesson learn pf patient mutant egfr posit non small cell lung cancer nsclc benefit tyrosin kinas inhibitor tki treatment howev patient ultim develop acquir resist half attribut egfr exon tm mutat landmark public cancer research demonstr improv drug potenc pan human egfr inhibit pf second generat egfr tki compar first generat egfr tki pf show abil overcom tm mutat vitro potenti improv treatment outcom patient mutant egfr posit nsclc review preclin clinic develop pf reflect lesson learn detour experi see relat articl engelman colleagu cancer res | D002289;D008175 | T191 |
36,245,243 | fusobacterium colorect cancer import associ random coincid role microbiom human cancer becom area intens research controversi mani report highlight physic associ fusobacterium colorect cancer associ provid diagnost therapeut promis also given rise sever controversi regard influenc fusobacterium speci human colorect cancer discuss two area controversi surround emerg pathogen influenc fusobacterium colorect cancer prolifer effect fusobacterium immun microenviron colorect cancer | D015179;D005674;D064307 | T047;T028;T191;T001;T032 |
36,245,232 | phenylpropyl guanidinium magnet ionic liquid green select extract rna phenylpropyl guanidinium magnet ionic liquid pgmil design prepar extract rna complex sampl properti pgmil character vibrat sampl magnetomet fourier transform infrar spectromet thermogravimetr analyz transmiss electron microscop scan electron microscop singl factor analysi factor affect rna extract process pgmil volum temperatur extract time ph systemat investig abil pgmil select extract rna investig nanodrop optim condit extract effici rna reach propos extract method demonstr extract rna seri complex sampl matric includ metal ion mixtur medicin yeast extract retain rna could readili recov simpli use tris hcl buffer recoveri rate regener studi shown extract effici pgmil chang signific use time studi provid green rapid environment friend extract method select extract rna | D052578 | T103;T120 |
36,245,230 | high express folat receptor alpha associ poor prognosi patient cervic cancer folat receptor fr membran protein express various solid tumor limit express normal cell therefor fr attract target cancer treatment studi aim investig relationship fr express clinicopatholog characterist surviv cervic cancer | D002583;D002294 | T191 |
36,245,229 | prognost influenc earli time chemotherapi follow primari cytoreduct surgeri advanc epitheli ovarian cancer current investig analyz prognost role time chemotherapi ttc interv follow primari cytoreduct surgeri patient advanc epitheli ovarian cancer | D065426;D010051 | T191;T061 |
36,245,228 | incid gastrointestin perfor associ bevacizumab combin neoadjuv chemotherapi first line treatment advanc ovarian fallopian tube periton cancer analysi japanes healthcar claim databas assess incid bevacizumab associ gastrointestin gi perfor first line treatment patient ovarian fallopian tube periton cancer receiv neoadjuv chemotherapi nac japanes real world clinic practic | D010051;D010534 | T191 |
36,245,227 | sp induc lncrna mcfl promot cisplatin resist ovarian cancer regul igfbpigfmekerk axi cisplatin resist huge problem encount ovarian cancer treatment studi probe role under mechan lncrna mcfl ovarian cancer cisplatin resist | D062085;D010051 | T191;T123;T114 |
36,245,219 | impact covid lockdown patient report outcom measur dutch hip knee arthroplasti patient first covid lockdown elect surgeri great reduc priorit patient greater need expect benefit term qualiti life advis lockdown also potenti affect follow outcom therefor studi compar patient report outcom measur prom retriev lockdown dutch primari total hip knee arthroplasti tha tka patient previous year | D019644;D019645;D000086382 | T061;T047;T067 |
36,245,218 | plap lineag trace singl cell transcriptom reveal cellular dynam periodont ligament periodont tissu support teeth alveolar bone socket via fibrous attach periodont ligament pdl pdl contain periodont fibroblast stemprogenitor cell collect known pdl cell pdlcs top osteoblast cementoblast surfac alveolar bone cementum respect howev characterist lineag hierarchi cell type remain poor defin studi identifi periodont ligament associ protein plap pdl specif extracellular matrix protein generat knock mice express creert gfp specif plap posit pdlcs genet lineag trace confirm long stand hypothesi pdlcs differenti osteoblast cementoblast pdl singl cell atlas defin cementoblast osteoblast plap ibspsparcl plap ibspcola respect popul nes mural cell sb schwann cell non stromal cell also identifi rna veloc analysi suggest plap highlya cell popul sourc pdlcs lineag trace plap pdlcs periodont injuri show periodont tissu regener pdlcs studi defin divers cell popul pdl clarifi role pdlcs periodont tissu homeostasi repair | D010513;D059467 | T023;T081;T030;T086 |
36,245,208 | invert v glansplasti updat techniqu outcom year later distal hypospadia common congenit urolog anomali numer correct procedur describ last year gold standard oper techniqu distal hypospadia switch meatal advanc glanuloplasti magpi procedur tubular incis plate tip urethroplasti modif magpi procedur first describ year ago invert v miv glansplasti improv upon magpi procedur reduc instanc meatal retract miv glansplasti uniqu compar mani common use procedur requir formal urethroplasti incorpor darto flap alway necessit extens mobil glan wing describ updat techniqu outcom miv glansplasti delin situat miv best employ | D007021 | T019 |
36,245,207 | success treat urethr condyloma acuminatum util intraurethr self applic fluorouracil via q tip condyloma acuminatum benign genit lesion associ low risk human papillomavirus subtyp approxim hpv associ genit wart occur urethra topic treatment urethr condyloma women challeng treat due difficulti appli medic maintain contact urethra long enough effect present case success clear urethr condyloma acuminatum treat via self applic use q tip | D003218;D014522 | T047 |
36,245,206 | obstruct ureter calculus caus massiv hydronephrosi renal allograft nephrolithiasi rare complic renal transplant patient obstruct calculus renal allograft often lack usual renal colic symptom therefor present atyp symptom treatment obstruct calculi imper prevent renal allograft failur complic report case year old man present year renal transplant renal failur massiv hydronephrosi secondari obstruct calculus | D006869;D007669;D016030;D014514 | T061;T047 |
36,245,205 | rare case isol scaphoid congenit megalourethra reconstruct congenit megalourethra first describ rare urethr anomali result dysgenesi penil corpus spongiosum without corpus cavernosum involv lead dilat penil urethra present come two form scaphoid fusiform former common result defici absent corpus spongiosum fusiform type much rarer consist absenc corpus spongiosum cavernosum present case involv surgic correct isol scaphoid type congenit megalourethra signific improv postop cosmet function outcom | D014521;D014564 | T023;T019 |
36,245,204 | robot distal ureterectomi implant obstruct metastat melanoma surgic consider palliat set non urotheli malign ureter obstruct muo caus hydronephrosi renal damag infecti sequela overal condit symptom plan system therapi inform urolog intervent well select case role definit reconstruct describ robot assist distal ureterectomi reimplant definit repair obstruct metastat melanoma | D008545;D065287;D014513;D014516 | T191;T061;T023 |
36,245,203 | short term reoper rate artifici urinari sphincter placement pediatr patient artifici urinari sphincter aus demonstr good function outcom pediatr popul sought examin nationwid short term reoper rate pediatr patient aus placement | D014550;D016741 | T047;T074 |
36,245,202 | detail cadaver analysi perives lymph node cystectomi specimen perives lymph node ad th edit american joint committe cancer ajcc stage bladder cancer current node inconsist evalu time radic cystectomi object studi provid detail anatom evalu perives lymph node | D015653;D001749 | T191;T061 |
36,245,201 | men prefer pre vasectomi consult telephon survey vasectom men due covid pandem teleconsult allow insur servic provinc quebec canada assess prefer vasectom patient pre vasectomi consult conduct person telephon | D000086382;D014659 | T047;T061;T101;T074;T067 |
36,245,200 | util ultrasonographi preoper assess tumor thrombi kidney cancer studi examin clinic accuraci ultrasonographi compar magnet reson imag mri intraop find evalu tumor thrombi level patient renal cell carcinoma | D002292;D007680;D013927 | T191;T046 |
36,245,199 | age stratifi contin outcom robot assist radic prostatectomi incontin robot assist radic prostatectomi rarp signific impact qualiti life studi aim compar age stratifi contin outcom canadian men undergo rarp | D011471;D065287;D014549 | T191;T061;T046 |
36,245,197 | effect prior prostat cancer treatment periop patholog outcom cystectomi comprehens analysi outcom periop patholog set patient prior diagnosi prostat cancer perform object studi describ effect prior prostat cancer treatment periop patholog outcom cystectomi | D011471;D001749 | T191 |
36,245,196 | hemorrhag cystiti review literatur treatment option hemorrhag cystiti hc morbid condit patient challeng urologist manag mani potenti contribut etiolog sever bleed variabl import consid clinic scenario formul manag strategi order provid highest qualiti care patient provid review literatur includ diagnosi treatment option | D003556;D006417 | T047 |
36,245,142 | variabl region p isoform alloster hard code dna interact alloster regul protein activ pervad biolog second secret life examin alloster regul mutant reactiv tumor suppressor protein p found general definit alloster effector includ entir protein expand mean bind site includ interfac transcript factor dna use understand modul protein activ cast variabl region p isoform alloster regul p interact consensus dna implement molecular dynam simul lab new techniqu molecular dynam md sector md markov state model investig effect nine natur occur splice variant isoform p find isoform differ wild type dynam properti interact dna consid implic find allosteri cancer treatment | D016159;D056004 | T066;T044;T123;T116 |
36,245,138 | drug resist characterist molecular type escherichia coli isol neonat class tertiari hospit multicentr studi across china escherichia coli common pathogen caus invas bacteri infect neonat recent year clinic antimicrobi suscept test demonstr increas rate drug resist e coli infect studi aim analys resist characterist e coli common antimicrobi agent perform multilocus sequenc type mlst clinic strain e coli collect chines neonat | D004926;D004927 | T007;T047 |
36,245,137 | molecular design prepar protein base soft ionic conductor tunabl properti protein base soft ionic conductor attract consider research interest recent year great potenti applic human machin interfac howev fundament mechanist understand ionic conduct silk base ionic conductor still unclear first develop environment friend scalabl method fabric silk base soft ionic conductor use silk protein calcium chlorid mechanist understand ion transport molecular interact calcium ion silk protein variabl water content investig depth combin experiment simul approach result show calcium ion primarili interact amid group protein low water content ionic conduct low sinc calcium ion confin around silk protein within water content increas calcium ion hydrat format water shell lead increas distanc calcium ion silk protein result motion calcium ion increas achiev higher ionic conduct optim ratio silk protein calcium ion water silk base soft ionic conductor good stretchabl self heal properti obtain protein base soft ionic conductor use fabric smart devic electrochrom devic | D002118;D047011 | T121;T123;T116;T196 |
36,245,136 | nutrit genet determin essenti hypertens among adult respond nation nutrit survey philippin preliminari observ studi prevent strategi hypertens sequela requir understand predispos condit recognit risk individu sever factor genet nongenet influenti like vari effect across ethnic studi aim identifi dietari lifestyl relat differ genet variant associ hypertens filipino studi includ adult filipino respond philippin nation nutrit survey live nation capit region data socio demograph profil select lifestyl factor obtain via face face interview blood pressur anthropometr biochem indic health determin use standard procedur hypertens incid determin follow american colleg cardiologyamerican heart associ guidelin genotyp util custom illumina golden gate genotyp array subsequ allel genotyp associ analyt genet variant effect adjust clinic paramet via logist regress without hypertens relat higher intak dietari protein fat carbohydr latter p note establish risk factor hypertens high lipid level fast blood sugar consist frequent seen among hypertens respond gene marker snps rs apoc utr rs cypc exon rs intergen pcdh diaph locus remain signific multivari logist regress studi highlight nutrit genet inform may contribut hypertens among filipino could guid public health initi identifi filipino suscept hypertens recommend control strategi lower morbid rate | D006973 | T047 |
36,245,122 | overproduct osracka effector target scaffold protein promot osrbohb mediat ros product confer rice floral resist fals smut diseas without yield penalti grain format fundament crop yield vulner abiot biotic stress rice grain product threaten fals smut fungus ustilaginoidea viren specif infect rice floral organ disrupt fertil seed format howev littl known molecular mechan u viren rice interact genet basi floral resist report u viren secret cytoplasm effector uvcbp facilit infect rice flower mechanist uvcbp interact rice scaffold protein osracka compet interact reduc nicotinamid adenin dinucleotid phosphat oxidas osrbohb lead inhibit reactiv oxygen speci ros product although analysi natur variat reveal osracka variant could avoid target uvcbp express level osracka correl field resist u viren rice germplasm overproduct osracka restor osracka osrbohb associ promot osrbohb phosphoryl enhanc ros product confer rice floral resist u viren without yield penalti taken togeth find reveal new pathogen mechan mediat essenti effector flower specif pathogen provid valuabl genet resourc balanc diseas resist crop yield | D012275 | T168;T002 |
36,245,119 | develop bariatr surgeri context precis medicin precis medicin base individu medicin new medic model develop cross applic genom sequenc technolog bioinformat big data scienc establish precis medicin model conduc maxim effici util medic resourc patient benefit bariatr surgeri emerg branch general surgeri new centuri although develop bariatr surgeri still long way go precis medicin add signific valu rapid posit develop branch bariatr surgeri context precis medicin bariatr metabol surgeri infanc current success implement precis control bariatr surgeri initi focus predict postop weight studi bodi weight differ epigenet howev still gap fill area postop recoveri nutrit support treatment realize individu treatment base big data futur integr larg scale resourc data inform realiz establish multi center clinic sampl librari perfect data collect long term follow clinic inform meanwhil conduct deep biolog data mine effect big data platform use data refer achiev accur predict control obes treatment formul detail implement plan detail procedur standard last least pay attent patient privaci prevent person health inform leakag | D050110;D057285 | T061;T091 |
36,245,118 | effect bariatr surgeri sex hormon male patient obes object analyz evalu differ sex hormon laparoscop roux en gastric bypass surgeri lrygb laparoscop sleev gastrectomi lsg male patient obes method studi retrospect cohort studi inclus criteria male patient obes met surgic indic chines guidelin surgic treatment obes type diabet edit patient bodi mass index bmi kgm obes relat metabol diseas patient sever obes bmi kgm sex hormon level check year surgeri exclus criteria includ patient endocrin diseas thyrotoxicosi hyperprolactinemia hypothalam pituitari lesion sever major organ dysfunct could toler anesthesia surgeri accord criteria clinic data male patient obes admit gastrointestin surgerybariatr center first affili hospit jinan univers octob januari includ total male patient obes includ studi mean age bodi weight bmi total testosteron level year kg kgm nmoll respect forti five patient exhibit testosteron defici among patient underw lsg lsg group underw lrygb surgeri lrygb group main outcom measur chang sex hormon level bariatr surgeri patient secondari outcom measur comparison chang sex hormon level lsg lrygb result pearson correl analysi show preoper estradiol posit correl waist circumfer r p hip circumfer r p chest circumfer r p testosteron negat correl bmi r p waist circumfer r p hip circumfer r p chest circumfer r p neck circumfer r p one year follow bariatr surgeri serum testosteron nmoll vs nmoll z p follicl stimul hormon iul vs iul z p progesteron nmoll vs nmoll z p level signific higher patient estradiol pmoll vs pmoll z p prolactin miul vs miul z p level decreas addit prolactin level lrygb group statist signific differ level estradiol p follicl stimul hormon p lutein hormon p progesteron p testosteron p compar preoper level lsg group statist signific differ level follicl stimul hormon p prolactin p testosteron p compar preoper level conclus degre obes men negat correl testosteron level lrygb lsg signific improv sex hormon level male patient obes testosteron level show signific increas surgeri | D050110;D003924 | T061;T047 |
36,245,117 | risk factor analysi bodi mass rebound laparoscop sleev gastrectomi establish nomogram predict model object investig potenti independ risk factor bodi mass rebound follow laparoscop sleev gastrectomi lsg construct nomogram predict model base factor method retrospect observ studi patient obes undergon lsg depart gastrointestin surgeri affili changzhou peopl hospit nanj medic univers januari juli retrospect enrol patient divid accord status postop bodi mass rebound inclus criteria patient age year undergon lsg bariatr surgeri surgic indic accord chines guidelin surgic manag obes type diabet mellitus exclus criteria patient undergon bariatr surgeri take weight loss drug drug affect bodi weight sever gastroesophag reflux hiatal hernia pregnant incomplet clinic data lost follow follow year total patient obes male femal undergon lsg surgeri enrol mean age bodi mass index bmi year kgm respect patient follow till juli focus bodi weight postop bodi mass rebound defin percentag increas nadir bodi mass lowest bodi mass year follow period bodi weight rebound follow lsg influenc factor observ base nomogram model construct evalu relationship patient basic data clinic indic preoper hematolog indic postop indic bodi weight rebound follow lsg analyz via univari analysi independ risk factor screen multivari logist regress analysi factor statist signific differ includ nomogram predict model moreov model intern model set extern valid set baselin data match patient obes center valid use receiv oper characterist roc curv calibr curv decis curv analysi dca via r softwar roc curv analysi use analyz predict cutoff valu measur data bodi mass rebound result overal patient exhibit postop bodi weight rebound lowest bmi kgm time reach lowest bmi month patient exhibit bodi weight rebound lowest bmi kgm time reach lowest bmi month result univari analysi show bmi depress anxieti c reactiv protein crp level system immun inflammatori index sii prognost nutrit index pni albuminfibrinogen ratio afr associ bodi weight rebound follow lsg statist signific differ p result multivari regress analys suggest depress odd ration confid interv ci p preoper crp level mgl ci p sii ci p pni ci p afr ci p five independ risk factor bodi mass rebound nomogram predict model construct base multivari analysi result score pni sii afr crp depress respect total score calcul ad individu score risk factor use calcul probabl bodi mass rebound follow lsg evalu result nomogram model show c index sensit specif model valid set respect calibr curv analysi dca indic nomogram model good predict valu bodi mass rebound lsg conclus preoper depress crp mgl sii pni afr independ risk factor bodi mass rebound follow lsg henc nomogram predict model base factor effect predict bodi mass rebound patient undergo lsg | D019440;D003924;D010535 | T121;T061;T047;T060 |
36,245,116 | short term efficaci laparoscop sleev gastrectomi plus uncut jejunojejunostomi sg uncut jjb treatment obes prospect studi object analyz short term efficaci sleev gastrectomi plus uncut jejunojejunostomi sguncut jjb patient obes method prospect studi conduct general surgeri depart beij chaoyang hospit januari decemb nct inclus criteria patient bodi mass index bmi kgm type diabet mellitus tdm least two comorbid bmi kgm waist circumfer cm male cm femal age year exclus criteria includ patient pregnant diagnos sever neurolog mental ill long term user antidepress immunosuppress diagnos sever gastroesophag reflux diseas underw revis surgeri patient incomplet follow data insuffici follow time also exclud patient divid sg uncut jjb group sg group accord doctor recommend patient will primari endpoint percentag excess weight loss ewl secondari endpoint percentag total weight loss twl tdm remiss rate patient regular follow end decemb result exclud seven patient meet inclus criteria elig patient final identifi sguncut jjb group sg group oper time minut vs minut z p total cost yuan vs yuan p slight higher sguncut jjb group sg group p conclus sguncut jjb might achiev promis weight loss effect similar sg relat lower incid postop nausea vomit might effect safe approach obes manag | D003924;D015390;D010535;D009767 | T061;T047;T060 |
36,245,115 | analysi earli sever postop complic risk factor patient underw bariatr metabol surgeri singl cent object analyz incid earli sever complic follow bariatr metabol surgeri experi diagnosi treatment risk factor method retrospect observ studi clinic data patient underw bariatr metabol surgeri may may depart bariatr metabol surgeri first affili hospit nanj medic univers retrospect collect among patient male femal mean age bodi mass index bmi patient time oper year kgm respect regard surgic type patient underw sleev gastrectomi sg underw roux en gastric bypass rygb underw sleev gastrectomi plus jejunojejun bypass sgjjb underw singl anastomosi duoden switch sad inclus criteria patient clavien dindo grade iii undergo sg rygb sg jjb sad complet clinic data exclus criteria patient undergo revision surgeri oper bariatr metabol surgeri clavien dindo classif use analyz incid earli sever postop complic prognosi earli sever postop complic defin clavien dindo iii complic within day surgeri meanwhil multivari logist regress model use identifi risk factor complic result summari earli sever complic follow bariatr metabol surgeri patient male femal exhibit earli sever complic mean age bmi patient year kgm respect preoper patient hypertens type diabet mellitus respiratori failur heart failur sever complic includ patient grade iiia grade iiib grade iva grade v complic incid sever postop complic differ surgic procedur sg rygb sgjjb sad common sever complic leakag patient bleed patient obstruct patient manag complic grade iiia complic includ eight patient leakag one sever inflamm treat antibiot nasogastr nutrit tube placement ct guid drainag grade iiia complic five patient bleed treat reoper patient recov four patient leakag treat reoper wherein three convert rygb one patient underw resutur leakag site two patient obstruct treat adhesiolysi patient grade iva complic includ respiratori failur complic acid aspir treat icu grade v complic bleed patient sgjjb treat reoper confirm bleed short gastric vessel unfortun patient die risk factor analysi earli sever complic univari analysi detect sex age type diabet mellitus oper time surgic type associ postop complic p howev multivari analysi indic age year odd ratio confid interv ci p surgic type sad ci p rygb ci p sgjjb ci p independ risk factor earli sever complic follow bariatr metabol surgeri conclus bariatr metabol surgeri safe common postop complic includ leakag bleed obstruct requir earli detect diagnosi treatment improv treatment outcom age surgic type independ risk factor earli sever complic follow bariatr metabol surgeri | D050110;D003924;D015390;D009767;D012131 | T061;T047;T046 |
36,245,114 | effect metabol surgeri islet function asian patient type diabet type diabet high profil global public health problem particular asia young age onset low bodi mass index earli appear pancreat islet dysfunct characterist asian patient tdm metabol surgeri becom standard treatment tdm patient signific improv tdm varieti mechan includ modul energi homeostasi reduct bodi fat mass inde restor islet function also play integr role remiss tdm metabol surgeri islet function asian tdm patient improv signific proven short term long term effect addit islet function import criterion refer patient select prior metabol surgeri mechan islet function improv metabol surgeri clear postop anatom chang gastrointestin tract lead number hormon chang seem potenti caus includ glucagon like peptid gastric inhibitori polypeptid peptid yy ghrelin cholecystokinin author analyz current retrospect prospect studi effect metabol surgeri islet function asian tdm patient low bmi mechan summar clinic evid metabol surgeri improv islet function asian tdm patient low bmi discuss under mechan great signific realiz person precis treatment metabol surgeri improv clinic benefit | D050110;D003924 | T061;T047 |
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