PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
|---|---|---|---|
36,246,958 | upregul mir p contribut right ventricular remodel via calumenin pulmonari arteri hypertens right ventricular rv failur determin prognosi pulmonari arteri hypertens pah under mechan still unclear grow evid shown microrna particip rv remodel studi undertaken explor role mir p regul rv remodel induc pah two pah model use studi includ monocrotalin rat model hypoxiasu mous model mirna sequenc rt qpcr valid identifi mir p elev rv pah rat vitro mir p express increas angiotensin ii treatment mir p inhibit reliev angiotensin ii induc cardiomyocyt hypertrophi luciferas report assay show calumenin target gene mir p pretreat mir p inhibitor could rescu calumenin downregul induc angiotensin ii hc cell moreov intracellular ca concentr apoptosi increas angiotensin ii treatment mir p inhibit decreas intracellular ca accumul apoptosi final vivo mir p downregul antagomir mir p attenu rv remodel rescu calumenin downregul condit hypoxiasu exposur work highlight role mir p calumenin rv remodel may lead develop novel therapeut strategi right heart failur | D006976;D035683;D000081029 | T123;T047;T046;T114 |
36,246,937 | macrophag deriv sonorespons nanoparticl sonodynam anticanc therapi mani nanocarri current develop potenti tumor target still sever limit applic clinic treatment crucial explor novel nanocarri higher biocompat target effici overcom barrier tumor microenviron penetr deepli tumor | D053758;D014464 | T061;T073 |
36,246,936 | synergi polydopamin nanovaccin endostar algin hydrogel improv antitumor immun respons colon tumor tumor immunotherapi novel type therapeut treatment wide rang applic potenti prolong benefit howev current immunotherapi low overal respons rate treat varieti tumor combin immunotherapi therapi improv therapeut respons rate purpos work explor potenti anti angiogen treatment combin tumor cell lysat load polydopamin nanoparticl vaccin therapeut strategi colon tumor | D018414;D003110 | T191;T025 |
36,246,935 | sustain deliveri methylsulfonylmethan biodegrad scaffold enhanc effici bone regener popular dietari supplement contain sulfur compound methylsulfonylmethan msm wide use altern oral medicin reliev joint pain reduc inflamm promot collagen protein synthesi howev rare use develop bioactiv scaffold bone tissu engin | D000469;D054457 | T122;T126;T116 |
36,246,934 | multidynam osteogen differenti effect polydopamin micro arc oxid manipul nanostructur modif oral implant surfac effect mimic morpholog natur bone tissu allow osteoblast achiev prolifer differenti capabl bone interfac dental implant improv osteoinduct activ surfac titanium implant rapid osseointegr prepar novel composit coat mao pda nc micro arc oxid techniqu immers method evalu prolifer adhes osteogen differenti osteoblast coat | D015921;D010012 | T074;T042 |
36,246,933 | selenium nanoparticl enrich lactobacillus casei atcc prevent cognit dysfunct mice modul microbiota gut brain axi bidirect communic gut central nervous system mediat gut microbiota close relat occurr develop neurodegen diseas includ alzheim diseas ad selenium se identifi play role ad probiot benefici effect host brain function behavior modul microbiota gut brain axi herein evalu protect effect lactobacillus casei atcc l casei atcc selenium nanoparticl enrich l casei atcc l casei atcc senp galactosealuminum chlorid induc ad model mice | D060825;D000069196;D007780;D053758;D019636;D012643 | T123;T121;T007;T073;T196;T047;T001;T048 |
36,246,931 | magnet reson imag supra cervic fetal membran detect increas risk prelabor ruptur membran term deliveri preterm deliveri fetal membran fm ruptur labor howev abil predict case prematur ruptur membran prom preterm prematur ruptur membran pprom limit paper object determin whether predict method base weight magnet reson imag mri supra cervic fm could predict prom pprom | D005322 | T047;T046 |
36,246,930 | proteom profil whole plasma plasma deriv extracellular vesicl facilit detect tissu biomark non obes diabet mous mechan pancreat beta cell destroy type diabet td remain fulli understood recent observ indic diseas may aris differ pathobiolog mechan endotyp discoveri one sever protein biomark measur readili avail liquid biopsi eg blood plasma pre diabet period may enabl person diseas intervent recent studi shown extracellular vesicl ev sourc tissu protein liquid biopsi use plasma sampl collect pre diabet non obes diabet nod mice experiment model td address combin analysi whole plasma sampl plasma deriv ev fraction increas number uniqu protein identifi mass spectrometri ms compar analysi whole plasma sampl alon lc msms analysi plasma sampl deplet abund protein subject peptid fraction identifi protein analysi ev enrich plasma sampl identifi protein protein detect ev enrich sampl third identifi whole plasma sampl mani classifi either tissu enrich tissu specif origin conclus parallel profil ev enrich plasma fraction whole plasma sampl increas overal proteom depth facilit discoveri tissu enrich protein plasma appli plasma sampl collect longitudin nod mous model pathobiolog mechan integr proteom profil scheme describ herein may use discoveri new potenti endotyp specif biomark td | D003922;D000067128;D011236 | T026;T047 |
36,246,929 | metabol effect prolactin role dopamin agonist review prolactin polypeptid hormon well known role reproduct physiolog recent studi highlight role neurohormon appetit regul metabol elev prolactin level wide associ worsen metabol diseas appear low prolactin level could also metabol unfavor review discuss pathophysiolog prolactin relat metabol chang less common recogn effect prolactin adipos tissu pancrea liver small bowel furthermor effect dopamin agonist metabol profil patient hyperprolactinemia discuss well | D006966;D010911;D015175 | T047;T191 |
36,246,928 | gut microbiota associ differenti metabol characterist studi defin cohort african chines studi intend determin associ gut microbiota glucos respons healthi individu analyz connect gut microbiom glucos metabol relat paramet | D000069196;D006943;D007333;D061385 | T121;T007;T033;T047;T046;T001 |
36,246,927 | recognit fold function specif site ligand bind domain thyroid hormon receptor like famili thyroid hormon receptor like thr like famili largest transcript factor famili belong nuclear receptor superfamili direct bind dna regul gene express therebi control various metabol process ligand depend manner thr like famili contain receptor thrs rar vdr ppar ror rev erb car pxr lxrs other thr like receptor involv mani aspect human health includ develop metabol homeostasi therefor consid import therapeut target various diseas osteoporosi ricket diabet etc | D011988;D012279 | T047;T116;T192 |
36,246,926 | prognost factor mitotan treatment adrenocort cancer two decad experi institut case seri studi aim characteris clinicopatholog featur prognost factor larg cohort hungarian patient adrenocort cancer diagnos | D000306;D018268 | T191 |
36,246,925 | role gaba islet function gamma aminobutyr acid gaba non proteinogen amino acid neurotransmitt produc islet level high brain gaba synthes enzym glutam acid decarboxylas gad kda isoform gad major autoantigen type diabet origin describ releas via synapt like microvesicl insulin secretori vesicl beta cell understood releas substanti quantiti gaba direct cytosol via volum regul anion channel vrac releas gaba influenc activ multipl islet cell type ionotrop gaba receptor metabotrop gaba b receptor gaba also interfac cellular metabol atp product via gaba shunt pathway beta cell becom deplet gaba type diabet remain beta cell type diabet suggest loss reduct islet gaba correl diabet pathogenesi may contribut dysfunct alpha beta delta cell diabet individu function gaba nervous system well understood descript islet gaba system cloud differ report describ multipl secret pathway effector function review discuss attempt unifi major experiment result year literatur character role gaba islet | D003922;D003924;D007515 | T047;T023 |
36,246,924 | serum free triiodothyronin free thyroxin ratio potenti prognost biomark chronic kidney diseas patient glomerular crescent retrospect studi crescent format indic sever glomerular patholog hypothyroid usual predict poor prognosi sever diseas howev relationship thyroid function progress chronic kidney diseas ckd unclear studi analys prognost predict valu serum free triiodothyronin ft free thyroxin ft ratio correl renal function patient ckd crescent format | D051436;D014284 | T125;T121;T047;T116 |
36,246,923 | depress contraind anterior cervic decompress fusion cervic spondylosi evalu whether depress contraind anterior cervic decompress fusion acdf cervic spondylosi | D013123;D055009 | T061;T047 |
36,246,922 | mechan negat modul fsh signal salt induc kinas rat granulosa cell optim develop preovulatori follicl need follicl stimul hormon fsh recent find reveal salt induc kinas sik inhibit fsh action human rodent report seek increas understand molecular mechan control sik particip inhibit fsh action primari rat granulosa cell gcs result show fsh caus transient induct sik mrna contrast sik inhibit effect fsh receptor express next determin whether sik inhibit enhanc effect sever sequenti direct activ fsh signal pathway find reveal sik inhibit stimul induct steroidogen gene forskolin camp protein kinas pka camp respons element bind protein creb strike fsh stimul creb akt phosphoryl affect sik inhibit therefor analyz express activ putat creb cofactor demonstr gcs express creb regul transcript coactiv crtc fsh treatment sik inhibit increas nuclear express factor conclud sik target fsh pathway affect factor locat camppka creb propos sik control activ crtc ovarian gcs find demonstr first time sik blunt respons gcs fsh camp pka creb provid evid crucial role sik regul ovarian function femal fertil | D051057;D011962 | T126;T116;T192 |
36,246,921 | distinguish metastat benign adren mass patient extra adren malign adren gland common organ involv metastasi studi aim compar adren metastas am adren benign mass abm patient extra adren malign stage follow | D000310;D016609 | T191 |
36,246,920 | effect serum progesteron level hcg trigger day pregnanc outcom gnrh antagonist cycl present studi analyz effect hcg trigger day progesteron p level live birth rate lbr gonadotropin releas hormon gnrh antagonist protocol | D007987;D010062;D011374 | T061;T121;T123;T116;T109;T125 |
36,246,919 | free fatti acid receptor endocrin regul glucos metabol insight gastrointestin pancreat adipos interact glucos metabol primarili control pancreat hormon coordin assist hormon gastrointestin adipos tissu studi unfold sophist hormon gastrointestin pancreat adipos interact network essenti maintain glucos homeostasi respons chang substrat nutrient free fatti acid ffas import substrat involv glucos metabol ffas abl activ g protein coupl membran receptor includ gpr gpr gpr gpr specif express pancreat islet cell enteroendocrin cell well adipocyt activ ffa receptor regul secret hormon pancrea gastrointestin adipos tissu influenc glucos metabol review present effect ffa receptor glucos metabol via hormon gastrointestin pancreat adipos interact under intracellular mechan furthermor develop therapeut drug target ffa receptor treatment abnorm glucos metabol type diabet mellitus summar | D003924;D005230 | T047;T109 |
36,246,918 | renal fat fraction signific associ risk chronic kidney diseas patient type diabet ectop fat deposit close relat chronic kidney diseas ckd current popul studi conduct determin relationship renal parenchyma fat deposit risk ckd among patient type diabet mellitus tdm therefor employ magnet reson imag mri detect renal parenchyma fat content individu tdm express renal fat fraction ff explor whether renal ff import risk factor ckd patient tdm | D003924;D051436 | T047 |
36,246,917 | implement thyroid relat patient report outcom routin clinic practic patient report outcom pros increas use clinic practic improv clinic care multipl studi show systemat use pros enhanc communic patient improv patient satisfact symptom manag qualiti life data aggreg examin health level patient group improv qualiti care compar patient outcom institut region nation level howev barrier challeng handl appropri achiev success implement pros routin clinic practic paper briefli overview thyroid relat pros describ unsolv qualiti life issu benign thyroid diseas provid exampl routin collect pros summar key point facilit success implement thyroid relat pros routin clinic practic final paper touch upon futur direct pro research | D011788;D013961 | T078;T023 |
36,246,916 | contribut immun cell bone metastasi pathogenesi bone metastasi close relat surviv rate cancer patient reduc qualiti life bone marrow microenviron contain complex immun cell compon local microenviron conduc tumor format growth uniqu immun environ varieti immun cell includ cell natur killer cell macrophag dendrit cell myeloid deriv suppressor cell particip process bone metastasi review introduc interact immun cell cancer cell bone microenviron obtain detail contribut implic bone metastasi discuss immunotherapeut strategi target immun cell cancer patient bone metastasi | D001859;D000072737 | T191;T025 |
36,246,915 | extern valid clinic applic predict model sever hypoglycemia intern valid one year risk predict model sever hypoglycemia sh type diabet evalu general hospit set extern verifi valid perform | D003924;D007003 | T047 |
36,246,914 | exercis type diabet mellitus blood glucos implic exercis time scientif literatur show exercis mani benefit individu type diabet yet sever barrier exercis popul exist post exercis hypoglycaemia hyperglycaemia sever studi suggest time exercis may import factor prevent exercis induc hypoglycaemia hyperglycaemia howev pauciti evid sole focus summaris find regard exercis time impact glucos metabol type diabet report suggest resist high intens interv exercisetrain often known hiit may best commenc time day individu like experi hypoglycaem event ie afternooneven due superior blood glucos stabil resist hiit exercis provid continu aerob base exercis advis perform morn due circadian elev blood glucos time therebi provid ad protect hypoglycaem episod ultim evid concern exercis time glycaem control remain embryon stage care design investig nexus requir could har determin effect possibl safest time exercis type diabet | D003922;D006943;D007003 | T033;T047 |
36,246,913 | associ obes phenotyp left ventricular mass index left ventricular hypertrophi children adolesc argu metabol healthi obes mho increas risk cardiovascular diseas aim studi evalu whether popul obes childrenadolesc metabol unhealthi obes muo phenotyp associ higher left ventricular mass index andor higher preval left ventricular hypertrophi mho phenotyp also test whether addit insulin resist index homa index th percentil sex age presenc hyperuricemia serum uric acid th percentil sex age definit muo better identifi obes children earli cardiac damag left ventricular hypertrophi defin presenc left ventricular mass index greater equal age sex specif th percentil studi popul includ obes children male mean age standard deviat year muo left ventricular mass index higher muo children mho children vs gm p wherea percentag muo children present left ventricular hypertrophi slight higher muo children vs p multipl linear regress analys show variabl signific associ higher left ventricular mass index male gender p bodi mass index z score p waist height ratio p multipl logist regress analys show presenc left ventricular hypertrophi signific associ higher bodi mass index z score p waist height ratio p spite higher left ventricular mass index muo compar mho children muo phenotyp signific predictor either higher left ventricular mass index higher left ventricular hypertrophi preval muo phenotyp low predict abil presenc left ventricular hypertrophi area receiv oper characterist curv sensit specif addit insulin resist hyperuricemia definit muo chang result observ standard definit muo multivari analysi muo phenotyp appear littl use identifi earli presenc cardiac damag larg popul obes children adolesc excess weight abdomin obes confirm import determin earli organ damag obes children | D033461;D007333;D024821;D000067329;D063766 | T033;T184;T047;T046 |
36,246,911 | explor risk factor impair fast glucos middl age popul live south korean communiti use categor boost machin epidemiolog studi identifi factor associ impair fast glucos use subject year old year old without diabet mellitus nation survey data develop nomogram could predict group vulner impair fast glucos use machin learn | D001786;D011236 | T047;T109 |
36,246,910 | preserv effect imeglimin pancreat cell mass noninvas evalu use exendin spectct imag perspect mitochondri involv progress loss cell mass bcm pernici influenc type diabet mellitus tdm evalu bcm convent requir invas method provid cross section data howev noninvas approach longitudin assess bcm live subject use indium label exendin deriv lys bndtpa ahx exendin exendin develop recent imeglimin novel antidiabet agent report improv glycem control glucos stimul insulin secret gsis via augment mitochondri function howev influenc imeglimin bcm fulli understood investig effect imeglimin bcm vivo prediabet dbdb mice use noninvas exendin singl photon emiss comput tomographycomput tomographi spectct techniqu week studi period imeglimin treatment attenu progress glucos intoler imeglimin treat mice retain greater bcm control consist result exendin spectct scan furthermor immunohistochem analysi reveal reduc cell apoptosi imeglimin treat dbdb mice also lower releas cytosol cytochrom c protein cell furthermor electron microscopi observ membran potenti measur reveal improv structur integr membran potenti mitochondria imeglimin treat islet respect result demonstr attenu progress bcm loss prediabet dbdb mice part via inhibit mitochondria mediat apoptosi | D003924;D011236 | T047 |
36,246,909 | vitro propag xxi human klinefelt spermatogoni stem cell step toward new fertil opportun klinefelt syndrom ks character masculin phenotyp supernumerari sex chromosom xxi impair fertil due loss spermatogoni stem cell sscs earli testicular cryopreserv could option futur fertil treatment patient includ sscs transplant vitro spermatogenesi critic essenti adapt current vitro sscs propag system fertil option ks patient ks human testicular sampl year old non mosaic ks boy donat patient enrol experiment testicular tissu bank program testicular cell isol cryopreserv tissu propag long term cultur day cell specif gene express confirm presenc four main cell type found test spermatogonia sertoli leydig peritubular cell popul zbtb undifferenti spermatogonia identifi throughout cultur use digit pcr flow cytometr analysi also detect hla cd cdf popul indic mainten stem cell subpopul among spermatogoni cell fish stain chromosom x show cell contain xxi karyotyp smaller number contain either xy xx xy xx popul abl enrich magnet sort cd spermatogonia marker molecular karyotyp demonstr genom stabil cultur cell time final singl cell rnaseq analysi confirm transcript id tcn nano within popul putat sscs popul first studi show success isol long term vitro propag human ks testicular cell find could inform develop therapeut fertil option ks patient either vitro spermatogenesi transplant ssc vivo | D007713;D013093 | T049;T047;T025;T019 |
36,246,908 | osteocyt pathogenesi hypophosphatem ricket sinc phosphorus compon hydroxyapatit prolong depriv affect bone miner fibroblast growth factor fgf essenti maintain phosphat homeostasi main produc osteocyt fgf increas excret inorgan phosphat pi decreas product dihydroxyvitamin kidney osteocyt cell osteoblast lineag undergon termin differenti becom embed miner bone matrix osteocyt express fgf multipl gene respons hereditari hypophosphatem ricket includ phosphat regul gene homolog endopeptidas x chromosom phex dentin matrix protein dmp famili sequenc similar member c famc sinc inactiv mutat phex dmp famc boost product fgf molecul might consid local negat regul fgf mous studi suggest enhanc fgf receptor fgfr signal involv overproduct fgf phex defici x link hypophosphatem ricket xlh dmp defici autosom recess hypophosphatem ricket type sinc fgfr involv transduct signal evok extracellular pi pi sens osteocyt may abnorm diseas serum level sclerostin inhibitor wnt catenin signal secret osteocyt increas xlh patient mous studi suggest potenti inhibit sclerostin new therapeut option diseas elucid complex abnorm osteocyt fgf relat hypophosphatem diseas provid detail understand pathogenesi effect treatment | D053098;D063730 | T047 |
36,246,907 | gpi indic immun infiltr prognosi human breast cancer comprehens analysi glucos phosphat isomeras gpi play import part gluconeogenesi glycolysi interconvers glucos phosphat fructos phosphat clinic signific still remain unclear breast cancer brca analyz express gpi brca patient determin prognost valu result show express level gpi upregul brca patient high gpi express correl poor overal surviv os brca time high gpi express correl poor clinicopatholog characterist stage iii year old n negat estrogen receptor er posit analysi influenc gpi prognosi brca suggest gene protein posit correl gpi gene protein main involv cell cycl signal pathway addit studi observ gpi close relat n methyladenosin rna methyl modif immun cell infiltr ferroptosi relat gene express brca differ rna methyl alter immun cell infiltr ferroptosi relat gene express high gpi express group low gpi express group final found gpi brca gene alter brca patient gene alter gpi poor prognosi diseas free surviv dfs altogeth work strong suggest gpi may serv new prognost biomark brca patient | D001943 | T191 |
36,246,906 | ubiquitin like process tug protein mechan regul glucos uptak energi metabol fat muscl respons insulin stimul fat muscl cell mobil glut glucos transport cell surfac enhanc glucos uptak ubiquitin like process tug aspscr ubxd protein central mechan regul process recent advanc area review data support model intact tug trap insulin respons glut storag vesicl golgi matrix bind vesicl cargo n terminus matrix protein c terminus insulin stimul liber vesicl trigger endoproteolyt cleavag tug mediat uspm proteas cleavag occur fat muscl cell fibroblast cell type proteolyt process intact tug generat tugul ubiquitin like protein modifi n termin cleavag product adipocyt tugul modifi singl protein kifb kinesin motor carri glut vesicl cargo cell surfac muscl anoth motor may modifi cleavag intact tug tug c termin product extract golgi matrix p vcp atpas muscl fat cleavag product enter nucleus bind ppar pgc regul gene express promot fatti acid oxid thermogenesi stabil tug c termin product regul ate arginyltransferas depend n degron pathway may creat feedback mechan control oxid metabol although clear tug process coordin glucos uptak aspect physiolog metabol mani question remain pathway regul alter metabol diseas human | D005947;D047908;D025801 | T123;T121;T116;T109 |
36,246,905 | optim wait period frozen embryo transfer hysteroscop polypectomi propens score match analysi evalu optim wait period frozen thaw embryo transfer fet hysteroscop polypectomi hsc p | D047928 | T046 |
36,246,904 | relationship level vitamin leptin fgf girl young women polycyst ovari syndrom polycyst ovari syndrom endocrinopathi main affect adolesc girl young women childbear age girl presenc clinic biochem symptom hyperandrogen particular consid role vitamin defici insulin resist inflamm dyslipidemia obes ie diseas associ pcos investig may suggest involv pathophysiolog syndrom leptin shown stimul format fgf bone relationship incid dyslipidemia adipos tissu mass concentr fibroblast growth factor main aim present research project assess concentr vitamin calcium select hormon well concentr adipokin leptin girl diagnos polycyst ovari syndrom | D000089703;D020738;D011085;D014807 | T121;T116;T127;T125;T047 |
36,246,903 | pth fgf klotho vitamin regul calcium phosphorus genet epigenet beyond action sever bone miner ion regul name pth fgf klotho oh vitamin oh control calcium phosphat metabol molecul addit biolog effect relat cell signal metabol ultim surviv therefor factor tight regul various level genet epigenet protein secret cleavag review main determin miner homeostasi includ well establish genet post translat regul bring attent epigenet mechan affect function pth fgfklotho oh clinic relev epigenet mechan includ methyl cytosin cpg rich island histon deacetyl micro rna interfer exampl sporad pseudohypoparathyroid type b phpb diseas character resist pth action due blunt intracellular camp signal pthpthrp receptor associ abnorm methyl gnas locus therebi lead reduc express stimulatori g protein subunit gs post translat regul critic function fgf modif includ glycosyl phosphoryl regul cleavag fgf henc proport avail fgf biolog activ extens data oh vitamin receptor vdr regul gene much need learn regul reduc vdr express vdr mutat caus ricket thought contribut differ disord epigenet chang increas methyl vdr result decreas express associ sever cancer infect genet epigenet determin play crucial role function miner factor disord lead differ diseas relat bone beyond | D018167;D014807 | T121;T116;T127;T192 |
36,246,902 | identif valid signatur involv voltag gate chlorid ion channel gene predict prostat cancer recurr voltag gate chlorid ion channel clcs transmembran protein maintain chlorid ion homeostasi various cell accumul studi indic clcs relat cell growth prolifer cell cycl nevertheless role clcs prostat cancer pca systemat profil purpos studi investig express profil biofunct clcs gene construct novel risk signatur predict biochem recurr bcr pca patient identifi five differenti express clcs gene cohort construct signatur compos clcn clcn lasso cox regress analysi train cohort cancer genom atlas tcga test entir cohort tcga gse gene express omnibus geo use intern independ extern valid dataset signatur could divid pca patient high low risk group differ prognos appar correl clinic featur independ excel prognost indic enrich analysi indic signatur primarili concentr cellular process metabol process express pattern clcn clcn detect cohort base immunohistochemistri stain found clcn clcn high express pca tissu compar benign tissu posit associ higher gleason score shorter bcr free time function experi reveal clcn clcn downregul inhibit cell prolifer coloni format invas migrat prolong cell cycl promot apoptosi furthermor seahors assay show silenc clcn clcn exert potenti inhibitori effect energi metabol pca collect signatur could provid novel robust strategi prognost evalu improv treatment decis make pca patient | D002712;D011471 | T196;T191;T034 |
36,246,901 | diesel deriv pm induc impair cardiac movement follow mitochondria dysfunct cardiomyocyt particul matter pm pollut air expos human bodi inhal ingest skin contact accumul various organ throughout bodi organ accumul pm grow health concern particular cardiovascular system pm emiss form air solid particl liquid droplet fuel particular diesel combust pm size particl major risk factor approxim prematur death annual caus air pollut studi assess deleteri effect diesel deriv pm exposur hl mous cardiomyocyt cell line pm induc biolog chang includ ultrastructur intracellular reactiv oxygen speci ros generat viabil intracellular atp level analyz moreov analyz chang transcriptom use rna sequenc metabolom use gas chromatographi tandem mass spectrometri gc msms liquid chromatographi tandem mass spectrometri lc msms pm treat hl cell ultrastructur analysi use transmiss electron microscopi reveal disrupt mitochondri crista structur pm dose depend manner elev ros level reduct cell viabil atp level similar observ pm dose depend addit gene differenti express fold chang cut total identifi gene amino acid aa differenti express fold chang cut total identifi aa profil use bioinformat analysi ingenu pathway analysi ipa softwar found chang transcriptom metabolom high relat chang biolog function includ homeostasi ca depolar mitochondria function mitochondria synthesi atp cardiomyopathi moreov integr singl omic network construct combin transcriptom metabolom silico predict analysi ipa predict upregul mitochondria depolar ros generat cardiomyopathi suppress ca homeostasi mitochondri function atp synthesi occur pm treat hl cell particular cardiac movement hl signific reduc pm treatment conclus result assess harm effect pm mitochondri function analyz biolog chang relat cardiac movement potenti associ cardiovascular diseas | D000393;D052638 | T131;T167 |
36,246,900 | causal associ obes relat anthropometr indic bodi composit knee hip arthriti larg scale genet correl studi epidemiolog studi repeat investig associ obes relat anthropometr indic bodi composit osteoarthr oa howev result remain inconsist work aim investig genet correl causal associ obes relat anthropometr indic bodi composit knee hip oa | D015207;D020370 | T047 |
36,246,899 | ast alt ratio first trimest risk gestat diabet mellitus aspart aminotransferas alanin transaminas ratio astalt report affect risk type diabet tdm uncertain relationship gestat diabet mellitus gdm | D003924;D016640 | T047 |
36,246,898 | obes associ higher torqu teno viral load compar lean obes affect rise proport popul import risk factor unfavor outcom viral diseas includ sever acut respiratori syndrom coronavirus associ diseas torqu teno virus ttv ubiquit apathogen virus reflect immun function host aim studi investig associ obes ttv load indirect marker compromis viral immun respons | D000086382;D004266;D022783 | T047;T005;T067 |
36,246,897 | hypertens disord pregnanc polycyst ovari syndrom associ child communic social skill sex specif androgen depend manner prenat exposur testosteron implic etiolog autism spectrum disord asd hypertens disord pregnanc polycyst ovari syndrom associ hyperandrogen increas risk asd examin whether increas matern testosteron mediat relationship hyperandrogen disord hds pregnanc child communic social skill matern plasma collect second trimest parent report measur child communic social skill obtain year age particip enrol nullipar pregnanc outcom studi monitor mother numomb retrospect frequenc match cohort studi design identifi mother one hds match control women diagnos hd carri femal higher testosteron level compar carri male p compar femal control femal born women hd signific higher score social communic questionnair p matern testosteron partial mediat relationship diagnosi hd scq score among femal find point sex specif associ two hds hypertens disord pregnanc polycyst ovari syndrom child communic social skill mediat effect matern testosteron pregnanc research need understand placent mediat effect matern testosteron child brain develop neurodevelopment outcom | D000067877;D046110;D011085 | T047;T046;T048 |
36,246,896 | artifici intellig promot diagnosi screen diabet retinopathi deep learn evolv new form machin learn technolog classifi artifici intellig ai substanti potenti larg scale healthcar screen may allow determin appropri specif treatment individu patient recent develop diagnost technolog facilit studi retin condit ocular diseas metabol endocrinolog global diabet retinopathi dr regard major caus vision loss deep learn system effect accur detect dr digit fundus photograph optic coher tomographi thus use ai techniqu system high accuraci effici develop diagnos screen dr earli stage without resourc access special clinic deep learn enabl earli diagnosi high specif sensit make decis base minim handcraft featur pave way person dr progress real time monitor time ophthalm endocrin therapi review discuss cut edg ai algorithm autom detect system dr stage grade featur segment predict dr outcom therapeut ophthalm indic system diseas reveal ai | D003920;D003930;D012164 | T047 |
36,246,895 | higher matern thyroid resist indic associ increas neonat thyroid stimul hormon analys base huizhou mother infant cohort studi aim explor relationship matern thyroid function thyroid resist paramet neonat thyroid stimul hormon tsh | D006980;D010900 | T047 |
36,246,893 | effect weight loss pregnanc outcom neuron reproduct metabol hormon gene express profil granulosa cell obes infertil pcos patient undergo ivf et investig effect weight loss pregnanc outcom pcos relat neuron reproduct metabol hormon ovarian granulosa cell gene express profil obes pcos infertil patient undergo vitro fertil embryo transfer ivf et | D007247;D007333;D011085 | T033;T047;T046 |
36,246,892 | evolv role alarin physiolog diseas condit futur potenti clinic implic alarin member galanin famili neuropeptid wide express central nervous system peripher tissu human rodent initi isol fifteen year ago ganglion cell human neuroblastoma subsequ demonstr broad distribut blood vessel skin eye peripher central nervous system thymus gastrointestin tract endocrin organ differ speci alarin amino acid neuropeptid deriv altern splice galp gene miss exon found involv sever physiolog function includ feed behavior energi homeostasi glucos homeostasi bodi temperatur reproduct also vasoact anti inflammatori anti edema antimicrobi activ howev physiolog effect alarin fulli elucid receptor mediat effect current known unearth novel biolog effect alarin unidentifi receptor therefor task futur biomed research addit alarin involv various diseas condit metabol syndrom obes insulin resist type diabet diabet retinopathi hypertens cardiac fibrosi polycyst ovarian syndrom depress thus alarin may serv promis tool futur pharmacolog treatment diagnosi research await confirm whether alarin protect patholog role diseas articl provid comprehens review evolv implic alarin varieti physiolog diseas condit futur perspect | D000890;D003924;D009479 | T121;T047;T116;T123 |
36,246,891 | membran estrogen signal femal reproduct motiv estrogen receptor initi identifi uterus later throughout brain bodi intracellular ligand regul transcript factor affect genom chang upon ligand bind howev rapid estrogen receptor signal initi outsid nucleus also known occur via mechan less clear recent studi indic tradit receptor estrogen receptor estrogen receptor also traffick act surfac membran signal cascad membran bound estrogen receptor mer rapid effect cellular excit ultim affect gene express seen phosphoryl creb princip mechan neuron mer action glutam independ transactiv metabotrop glutam receptor mglur elicit multipl signal outcom interact mer mglur shown import mani divers function femal includ limit reproduct motiv review membran initi estrogen receptor signal femal focus interact mer mglur | D011960;D018094 | T116;T192 |
36,246,890 | perspect metabolom earli diagnosi prognosi gestat diabet mellitus gestat diabet mellitus gdm one common metabol disord pregnant women earli detect gdm provid opportun effect treatment hyperglycemia pregnanc thus decreas risk advers perinat outcom mother newborn metabolom emerg techniqu offer novel point view understand onset develop diseas repeat use various gestat period recent studi gdm moreov metabolom provid vari opportun differ diagnos gdm prediabet predisposit diabet diagnosi gdm gestat age sever week earlier use tradit method assess prognosi consid physiolog subtyp gdm clinic index longitudin metabolom truli facilit dynam monitor metabol alter cours pregnanc herein review recent advanc metabolom summar evid studi applic metabolom gdm highlight aspect diagnosi differenti diagnos gdm earli stage also discuss futur studi direct concern physiolog subtyp prognosi limit metabolom | D016640;D011236 | T047 |
36,246,889 | associ alter matern lipid level birthweight term within famili comparison matern lipid level affect birthweight long term health offspr howev associ could influenc genet common factor | D000078064 | T033 |
36,246,888 | research progress ferroptosi diabet kidney diseas ferroptosi newli discov form cell death differ form regul cell death morpholog biochem genet level character iron depend accumul lipid peroxid ferroptosi close relat intracellular metabol amino acid lipid iron henc regul may facilit diseas intervent treatment diabet kidney diseas one serious complic diabet lead serious psycholog econom burden patient societi progress end stage renal diseas present effect treatment diabet kidney diseas ferroptosi recent identifi anim model diabet kidney diseas herein systemat review regulatori mechan ferroptosi associ differ form cell death summar relationship diabet kidney diseas explor regul interven progress diabet kidney diseas treatment | D003920;D003928;D000079403 | T047;T043 |
36,246,887 | complement receptor car osteoblast regul osteoclastogenesi experiment postmenopaus osteoporosi recent year evid accumul complement system integr part innat immun may involv regul bone homeostasi well inflammatori bone loss exampl rheumatoid arthriti periodont complement may also contribut osteoporosi develop investig mechan limit use mice condit delet complement anaphylatoxin receptor car demonstr car osteoblast car runx cre mice osteoclast car lysm cre mice affect physiolog bone turnov age relat bone loss either sex confirm micro comput tomographi histomorphometri biomechan analys bone measur bone turnov marker blood serum femal mice subject ovariectomi ovx common model postmenopaus osteoporosi signific bone loss induc car flfl car lysm cre mice demonstr signific reduc bone volum fraction trabecular number thick well increas trabecular separ trabecular bone compart confirm osteoclast number receptor activ nuclear factor k b rank ligand rankl serum level signific elev mous line contrast car runx cre mice protect bone loss ovx serum rankl concentr increas ovx data suggest bone cell specif car may redund bone homeostasi regul physiolog condit howev car osteoblast crucial induct bone resorpt osteoporot condit stimul rankl releas wherea car osteoclast regul ovx induc bone loss therefor result implic car osteoblast potenti target treat postmenopaus osteoporosi | D010024;D015663 | T047 |
36,246,885 | impact genet variant cypc gene bladder cancer suscept bladder cancer common lead caus mortal around world previous studi indic genet factor signific associ bladder cancer progress instanc cypc gene involv bladder cancer progress howev littl known impact cypc genet polymorph bladder cancer risk aim detect associ cypc variat bladder cancer suscept | D001749 | T191 |
36,246,884 | hypothyroid protect causal associ hepatocellular carcinoma two sampl mendelian random studi observ studi suggest associ hypothyroid risk hepatocellular carcinoma hcc causal direct effect still inconclus aim test whether hypothyroid causal associ risk hcc use mendelian random mr analysi | D006528;D007037;D008113 | T047;T191 |
36,246,883 | gamma glutamyl transferas high densiti lipoprotein cholesterol ratio valuabl predictor type diabet mellitus incid gamma glutamyl transferas ggt high densiti lipoprotein cholesterol hdl c proven valuabl predictor type diabet mellitus tdm aim studi investig associ ggthdl c ratio incid tdm | D003924;D005723 | T047;T126;T116 |
36,246,882 | gut microbiom metabol activ type diabet analysi base presenc gada type diabet td progress affect circul glutam acid decarboxylas antibodi gada persist mani year studi aim investig whether gut microbiom correl metabolit chang td presenc gada | D003922;D000069196 | T047;T007;T001 |
36,246,880 | oxid stress mediat beta cell death dysfunct target diabet manag biggest drawback current diabet therapi treatment consequ caus diseas regardless diabet type preserv recoveri function pancreat beta cell stand biggest challeng treatment diabet free radic oxid stress among major mediat autoimmun destruct beta cell type diabet td beta cell malfunct death provok glucotox insulin resist type diabet td addit oxid stress reduc function beta cell td stimul de tran differenti loss transcript factor critic beta cell develop matur regener review summar date clarifi redox relat mechan involv regul beta cell ident death underlin similar differ td td protect effect natur antioxid oxid stress induc beta cell failur also discuss consid oxid stress affect epigenet regulatori mechan involv regul pancreat beta cell surviv insulin secret review highlight huge potenti epigenet therapi special attent paid applic state art crisprca technolog base target epigenom edit purpos chang differenti state differ cell type make insulin produc abil attenu diabet clarif mention mechan could provid better insight diabet etiolog pathogenesi would allow develop novel potenti effici therapeut strategi prevent revers beta cell loss | D003922;D003924;D050417 | T047;T025 |
36,246,879 | seabuckthorn polysaccharid combin astragalus polysaccharid amelior alcohol fatti liver regul intestin flora present incid alcohol fatti liver diseas afld increas year year numer studi confirm liver diseas close relat intestin flora seabuckthorn astragalus membranaceus tradit chines medicin tcm homolog medicin food good liver protect polysaccharid regul intestin flora studi effect hrp ap combin two polysaccharid intestin flora afld mice provid scientif basi treatment afld two polysaccharid | D027883;D005235;D000069196;D031281 | T001;T047;T007;T002 |
36,246,878 | exenatid improv hepatocyt insulin resist induc differ region adipos tissu obes result energi surplus character abnorm adipos tissu accumul andor distribut adipokin secret differ region adipos tissu induc chang key protein insulin signal pathway hepatocyt result impair hepat glucos metabol studi aim investig whether exenatid affect key protein irspikakt signal pathway hepatocyt alter differ region fat depot six non obes patient without endocrin diseas select research subject subcutan adipos tissu sat viscer adipos tissu vat co cultur hepg cell transwel chamber presenc absenc exenatid adipokin content supernat experiment group detect elisa addit hepg cell co cultur group without insulin collect express key protein ir p ir pik p akt p akt detect western blot wb result show adipokin il mcp vegf stnfr supernat hepg cell induc differ region adipos tissu signific higher hepg group vat releas adipokin sat furthermor adipokin signific inhibit exenatid import differ region fat depot affect irspikakt insulin signal pathway hepatocyt exenatid regul express hepatocyt protein ir pik p p akt inhibit adipos tissu regul express hepatocyt protein p ir promot adipos tissu effect vat express key protein hepatocyt signific sat statist differ express akt protein among experiment group suggest exenatid influenc express akt protein hepatocyt conclus exenatid may improv hepat insulin resist ir inhibit adipokin regul express key protein irspikakt pathway | D007333 | T046 |
36,246,877 | crisprca mediat mutat insulin like peptid encod gene affect growth ridgetail white prawn exopalaemon carinicauda insulin like peptid ilp play key role anim growth metabol reproduct vertebr crustacean one type ilp insulin like androgen gland hormon iag report relat sex differenti howev function type ilp rare report identifi anoth type ilp ridgetail white prawn exopalaemon carinicauda ecilp ortholog drosophila melanogast ilp sequenc character express analys show ecilp similar vertebr insulinigf insect ilp heterodimer structur express profil use crisprca genom edit technolog generat ecilp knockout ko prawn ecilp ko individu signific higher growth inhibitori trait mortal normal group addit knockdown ecilp rna interfer rnai result slower growth rate higher mortal result indic ecilp import growth regul e carinicauda | D061385;D033541;D033561 | T121;T204 |
36,246,876 | primari aldosteron obstruct sleep apnea know thus far primari aldosteron obstruct sleep apnea well known caus hypertens contribut increas cardiovascular morbid mortal independ howev relationship two entiti remain unclear studi demonstr contradictori result review aim collat put perspect current avail research regard associ primari aldosteron obstruct sleep apnea relationship two entiti clinic characterist clinic implic outcom treatment potenti causal link mechan herebi present | D006929;D006973;D020181 | T047 |
36,246,875 | antioxid antirad activ depend adren tumor type aim studi assess total antioxidantoxid status plasma urin patient adren tumor studi group consist patient women men adren mass classifi three subgroup non function incidentaloma pheochromocytoma cushingsconn adenoma number patient set priori base previous experi test power antioxid activ total antioxid capac tac total oxid status tos oxid stress index osi antirad activ radic scaveng activ assay dpph ferric reduc antioxid power frap measur use colorimetr method frap level decreas plasma urin incidentaloma p pheochromocytoma p cushingsconn adenoma p dpph antirad activ plasma patient adren mass p plasma tac increas incidentaloma patient p wherea pheochromocytoma group p decreas plasma urin tos p osi p signific higher patient adren tumor pheochromocytoma patient plasma urin tac p p well plasma plasma dpph p urin frap p correl posit normethanephrin first show reduc radic scaveng capac plasmaurin patient adren mass nevertheless plasma tac signific higher incidentaloma group compar control therefor plasma urinari antioxid antirad activ depend presenc tumor lower level tac dpph frap clear indic reduc abil scaveng free radic thus lack effect protect oxid stress patient adren tumor plasma urin redox biomark use assess system antioxid status adren tumor patient | D000236;D000310;D010673 | T191 |
36,246,874 | relationship lipid risk score new onset hypertens prospect cohort studi dyslipidemia hypertens import risk factor atherosclerot cardiovascular diseas howev relationship dyslipidemia incid hypertens remain elucid comprehens main purpos studi construct lipid risk score explor risk predict effect integr lipid indic new onset hypertens | D050171;D006973 | T047;T046 |
36,246,873 | proxim ligat assay studi tsh receptor homodimer crosstalk igf receptor human thyroid cell proxim ligat assay pla methodolog permit detect protein protein close protein within nanomet cell tissu endogen protein level exogen overexpress detect protein high sensit specif employ dna hybrid step follow dna amplif pla use success mani type protein method paper describ work pla provid exampl use studi tshigf receptor crosstalk grave orbit fibroblast gof tsh receptor homodimer primari cultur human thyrocyt | D017526;D011989 | T126;T116;T192 |
36,246,872 | identif hub gene earli detect bone metastasi breast cancer global among women frequent detect diagnos lethal type cancer breast cancer bc particular bone one frequent distant metastas breast cancer patient bone metastasi aris approxim advanc patient thus need identifi valid earli detect marker differenti metastasi non metastasi breast cancer | D001859;D001943 | T191 |
36,246,871 | analysi thyroid involv children adult langerhan cell histiocytosi underestim endocrin manifest langerhan cell histiocytosi lch rare diseas caus clonal expans cdacd lch cell thyroid involv lch most describ case report | D003919;D006646;D007037;D013964 | T047;T191 |
36,246,870 | elev triglycerid glucos tyg index predict impair islet cell function hospit base cross section studi explor relationship tyg index insulin secret function pancreat cell determin possibl tyg index predict cell dysfunct develop diabet | D003920;D005947 | T123;T047;T121;T109 |
36,246,869 | vertic sleev gastrectomi normal circul glucocorticoid level lower glucocorticoid action tissu select mice glucocorticoid produc adren cortex essenti mainten metabol homeostasi glucocorticoid activ catalys hydroxysteroid dehydrogenas hsd excess glucocorticoid associ insulin resist hyperglycaemia small number studi demonstr effect glucocorticoid metabol bariatr surgeri group gastrointestin procedur known improv insulin sensit secret assum result weight loss studi hypothes reduct glucocorticoid action follow bariatr surgeri contribut wide observ euglycem effect treatment | D005743;D005938;D007333;D061385 | T061;T121;T109;T125;T039;T046 |
36,246,570 | upregul mir p amelior calcif aortic valv diseas inhibit bmp signal pathway develop calcif aortic valv diseas cavd complex process ectop calcif involv various factor lead aortic valv stenosi hemodynam chang sever case even sudden death current aortic valv replac effect method osteogen differenti aortic valv interstiti cell avic one key factor valv calcif emerg evid suggest bone morphogenet protein bmp induc proosteogen activ avic howev regulatori mechan under activ avic unclear present studi elucid high throughput rna sequenc rt qpcr mir p evid downregul calcif aortic valv also prove mir p involv regul osteogen differenti avic target predict analysi dual luciferas report gene assay confirm mir p preferenti bound bmp furthermor effect mir pbmp axi osteogen differenti avic examin use gain loss function approach final construct mous cavd model verifi effect mir pbmp axi aortic valv calcif leaflet vivo conclus mir p regul osteogen differenti avic negat regul bmp highlight mir p may potenti therapeut target cavd | D001024;D035683 | T123;T047;T114 |
36,246,569 | lifestyl improv vitamin supplement play import role prevent childhood diabet studi investig characterist insulin secret hydroxyvitamin oh level children obes | D003920;D007333;D063766;D014808 | T033;T047;T046 |
36,246,568 | analysi adrenocorticotrop hormon cortisol level acut respiratori distress syndrom covid patient sar cov infect may caus multipl organ failur howev scarc inform found impact endocrin system studi conduct determin plasma adrenocorticotrop hormon acth plasma cortisol level cohort covid patient acut respiratori distress syndrom ard | D000086382;D012128 | T047;T067 |
36,246,567 | heih promot malign progress gastric cancer regul stat mediat autophagi glycolysi studi clinic valu heih hyperexpress gastric cancer molecular mechan promot malign prolifer gastric cancer cell qrt pcr use detect express heih gastric cancer nontumor gastric tissu heih interfer sequenc construct downregul heih express mgc bgc cell line cck clonogenesi transwel assay use detect effect heih prolifer invas tumor cell protein level stat p stat p lc detect western blot result show heih high express gastric cancer p interfer heih express mgc bgc cell reduc prolifer invas gastric cancer cell result statist signific p heih act mirna spong mir heih promot gastric cancer develop inhibit mir stat downstream target mir heih inhibit autophagi promot glycolysi conclus heih high express gastric cancer heih promot malign prolifer develop gastric cancer cell heih may new candid site patholog diagnosi molecular drug therapi futur clinic treatment gastric cancer | D035683;D062085;D013274 | T123;T191;T114 |
36,246,566 | mechan xiaochaihu decoct treat hepat fibrosi explor network pharmacolog explor materi basi pharmacolog mechan xiaochaihu decoct xchd classic tradit chines medicin tcm formula inhibit hepat fibrosi hf | D004365;D044949 | T123;T121;T109 |
36,246,565 | urinari pca superior diagnost biomark prostat cancer among ghanaian men prostat cancer one common diagnos cancer men prostat specif antigen psa biomark choic screen diagnosi prostat cancer howev ineffici exist diagnost capabl studi thus evalu diagnost prognost potenti urinari pca altern biomark prostat cancer ghanaian popul | D017430;D011471 | T129;T191;T126;T116 |
36,246,564 | ultrasonographi combin blood biochemistri earli diagnosi diabet kidney diseas diabet kidney diseas dkd well recogn microvascular complic diabet mellitus perfus intraren arteri close relat develop dkd aim present studi investig relat ultrasonographi perform intraren arteri grade dkd | D003924;D003928 | T047 |
36,246,563 | analysi linc mir express colorect cancer patient via tissu microarray base fluoresc situ hybrid tissu microarray tma contain individu colorect tumor sampl adjac normal sampl construct express level linc mir detect fluoresc situ hybrid | D015179;D035683;D062085 | T123;T191;T114 |
36,246,562 | hspaa hspa hspa potenti molecular biomark prognosi among hsp famili alzheim diseas alzheim diseas ad chronic neurodegen diseas lead impair cognit memori heat shock protein hsp famili play import role pathogenesi ad known regul protein misfold varieti diseas includ inhibit aggreg nft format ad yet diagnost molecular marker ad remain unclear herein sought investig molecular marker hsp famili affect diagnosi treatment ad comput analysi studi intersect hsp famili member immun molecul taken screen immun relat hsp famili gene base dataset ncbi gene express omnibus geo databas found express level hspaa hspa signific increas ad sampl hspa signific decreas surpris combin hub gene good diagnosi ad via receiv oper characterist curv roc moreov clinic valu hub gene assess spearman correl analysi ad relat gene secretas activ secretas activ term immun cell infiltr show distribut seven immun cell type macrophag neutrophil cell cd memori activ macrophag nk cell activ plasma cell cell follicular helper associ occurr ad cibersort furthermor data suggest ep myc tp jun crebbp esr might key transcript factor tfs hub gene general find suggest hspaa hspa hspa potenti molecular biomark prognosi among hsp famili ad provid new perspect diagnost therapeut target ad | D000544;D019636 | T047;T048 |
36,246,561 | five emt relat gene signatur predict acut myeloid leukemia patient outcom epitheli mesenchym transit emt gene shown signific associ prognosi solid tumor howev lack model emt gene predict prognosi aml patient | D015470;D035683 | T123;T191;T114 |
36,246,560 | whole transcriptom analysi key gene signal pathway endogen ard analyz differenti express gene deg rat endogen acut respiratori distress syndrom ard lung injuri explor pathogenesi earli diagnost molecular marker use whole transcriptom data | D000073888;D055370;D035683;D012128;D062085 | T123;T047;T037;T114 |
36,246,559 | identif calcium channel relat gene prx prognosi immun infiltr prostat cancer prostat cancer one common malign men calcium signal implic progress prostat cancer play critic role immun cell function howev whether specif calcium channel relat gene play crucial role immun cell infiltr level prostat cancer requir research studi perform integr analysi transcript clinic somat mutat data cancer genom atlas databas identifi hub calcium channel relat gene prx associ prognosi immun infiltr prostat cancer prx express posit correl immun cell infiltr level express immun checkpoint gene downregul prx led poor surviv patient prostat cancer furthermor valid molecular clinic characterist prx use multipl databas conduct vitro experi addit drug sensit analysi reveal patient low prx express sensit docetaxel bicalutamid conclus reveal associ calcium channel relat gene prostat cancer identifi prx biomark earli diagnosi prognosi predict aid treatment decis patient prostat cancer | D015220;D011471 | T123;T191;T116 |
36,246,558 | predict protein protein interact site multifeatur fusion rf mrmr if predict protein protein interact ppi site one perplex problem drug discoveri comput biolog although signific progress made combin differ machin learn techniqu varieti distinct characterist problem still remain unresolv studi techniqu ppi site present use random forest rf algorithm follow minimum redund maxim relev mrmr approach method increment featur select if physicochem properti protein featur residu disord sequenc conserv secondari structur solvent access incorpor five structur characterist also use predict ppi site analysi featur show structur featur relat solvent access surfac area rasa surfac curvatur sc help predict ppi site result show perform propos predictor superior sever state art predictor whose averag predict accuraci sensit specif respect propos predictor expect becom help tool find ppi site featur analysi present studi give use insight protein interact mechan | D019295;D011506 | T123;T116;T091 |
36,246,557 | singl cell rna sequenc reveal activ involv macrophag polar pulmonari hypertens sustain hypoxia trigger progress rise pulmonari arteri pressur caus serious pulmonari diseas macrophag play import role along progress pulmonari hypertens howev state macrophag polar earli stage pulmonari hypertens unclear | D006976 | T046 |
36,246,556 | surviv prognosi characterist primari esophag small cell carcinoma comprehens explor surviv characterist primari esophag small cell carcinoma pscce identifi main factor affect prognosi | D018288;D004938 | T191 |
36,246,555 | correl clinicopatholog factor brain tumor relat epilepsi glioma glioma patient brain tumor relat epilepsi btre complex profil due simultan presenc two patholog glioma epilepsi howev tradit receiv much attent malign brain tumor under pathophysiolog brain tumor relat epilepsi remain poor understood purpos studi investig possibl correl molecular neuropatholog glioma btre wide rang btre associ molecular marker glioma patient | D001932;D004827;D005910 | T033;T047;T191 |
36,246,554 | estrogen protect renal ischemia reperfus injuri regul thtreg cell immun balanc inflamm critic mediat renal ischemia reperfus ir injuri iri lymphocyt exert key role renal iri induc inflamm connexin cx relat mainten lymphocyt homeostasi various preclin research report estrogen renoprotect agent base anti inflammatori potenti present research aim studi role lymphocyt activ cx estradiol mediat protect renal iri femal rat classifi six group control rat ir rat ovariectom rat ovariectom ir rat ovariectom rat treat estradiol gap level serum creatinin scr blood urea nitrogen bun paller score dramat increas ir rat especi ovariectom rat contrast indic mark decreas administ estradiol gap immunofluoresc stain reveal cd cell infiltr kidney tissu earli stage iri peripher blood renal tissu proport cd cd cell ratio cd cd high ir rat especi ovariectom rat proport cd cd cell low peripher blood high renal tissu administr estrogen gap revers effect il level serum tissu homogen signific increas ovariectom rat subject ir signific decreas estrogen gap treat rat opposit trend observ il level correl analysi demonstr il correl posit bun scr paller score il negat correl indic western blot show cx express mark increas peripher blood lymphocyt ir rat especi ovariectom rat intervent estrogen gap cx express signific downregul find indic cx may particip regul thtreg balanc estrogen renal iri | D018031;D015427 | T123;T116;T037 |
36,246,499 | rare case iatrogen invert stress cardiomyopathi discuss case year old femal admit chronic intract lower back pain requir elect spinal surgeri postop experienc chest pressur abdomin pain notabl elev cardiac marker cardiac catheter left ventriculogram reveal normal coronari arteri basal anterolater hypokinesi normal movement distal segment anterior wall rare variant stress cardiomyopathi diagnos | D054549 | T047 |
36,246,498 | simultan dual distal radial balloon aortic valvuloplasti larger aortic annuli dual distal mini balloon aortic valvuloplasti stabil year old patient sever aortic stenosi punctur radial arteri solv issu larg diamet aortic ring introduc feasibl strategi select case fragil octogenarian patient high hemorrhag risk move anatom snuffbox offer better postprocedur occlus rate better workspac ergonom procedur | D001024;D063126;D006348 | T061;T047 |
36,246,478 | empir studi influenc colleg student physic fit level public health compulsori cours univers physic fit import part public health present research physic fit lack comprehens evalu method accur guid public health base paper compar key factor affect public health aim better guid public health improv level public health paper colleg student select research object use statist analysi method find signific differ influenc factor regress analysi carri differ influenc factor determin key factor affect physic fit result show physic fit level exercis frequenc physic injuri key factor affect physic fit serious impact public health impact level therefor colleg sport depart set factor formul develop plan physic fit promot improv public health | D015444;D011634 | T061;T056;T091 |
36,246,477 | influenc mechan educ leadership environment account base big data algorithm last year big data techniqu teach overgrown make educ decis includ inform knowledg crucial compon start trend use big data algorithm strateg technolog advanc use analyz enorm amount inform develop strateg judgment current studi aim address issu convent instruct administr manag solut focus manual rule formul big data storag interpret poor effici analyz big data lack valu develop educ leadership qualiti studi suggest educ leadership model base big data algorithm elm bda explor student leadership perform reli cooper filtrat fuzzi c mean fcm big data differ influenc mechan factor direct link educ leadership also analyz use big data algorithm build intellig institut administr system research also expos organiz studi evalu big data research alreadi exist studi emphas expand signific big data addit studi explor effect big data analyt educ leadership qualiti util fcm score system design predict student leadership level use big data algorithm student motiv train improv skill educ learn method enhanc educ institut better decis make use big data leadership develop big data facilit effici educ decis make merg various data telecommun technolog use big data school increas leadership qualiti among student effect use big data decis make academ leader must creat new type learn monitor system | D000077558;D007857 | T078;T170;T054 |
36,246,476 | dilemma solut copyright justic system health short video network big data environ monitor short video quick taken mobil screen network user establish one signific social platform internetera new carrier social cultur short film qualiti high particip strong engag high real time quick propag satisfi need internet user interperson communic read enjoy leisur time backdrop network big data environ monitor base paper defin fair use system short video copyright elabor concept examin system challeng potenti fix context network develop model short video repeat detect use local key point accord experiment find algorithm short video repetit detect accuraci rate reach recal rate reach develop fair use system short video copyright current network environ video complex scene achiev good detect perform establish good data analysi foundat provid signific amount assist system escap predica | D000077558;D003309 | T170 |
36,246,475 | visual construct environment factor modern art work perspect paint art sinc twenti first centuri continu improv econom life peopl higher higher requir life present therefor explor better environment art design becom key concern mani peopl kind environment design reli develop modern art china analyz atmospher environment factor visual construct method modern art work integr geograph posit map construct slam artifici intellig analyz flavor time visual construct modern art believ slam algorithm combin full convolut network fcn superpixel crf better estim posit mani dynam scene therefor explor differ way integr art cultur modern art work modern social scienc technolog realiz modern environment art design seen slam system form combin visual construct environment factor modern art work suitabl peopl life current stage | D001185 | T090;T073;T066 |
36,246,474 | analysi question dialect relationship pursuit intens school physic health educ rapid develop countri school physic educ health program gradual becom essenti part school order improv student core physic educ skill literaci import role impact student physic mental health develop school p h program convey teacher student knowledg train skill improv school sport enhanc physic fit also fulli develop awar abil teacher student work hard collabor paper examin analyz problem dilemma associ pursuit health sport specif intens school sport combin theori health exercis physic educ train moral educ literatur review logic analysi valu analysi purpos paper clarifi differ logic orient specif sport intens regul school sport health pursuit school sport teach clarifi correct relat issu provid theoret practic support school sport better implement concept health first promot school sport reform sound develop paper analyz relationship exercis health physic educ program teacher school perspect natur dialect find outstand problem may exist effect promot develop student physic mental health | D010806;D012574 | T065;T092;T073 |
36,246,473 | psycholog adapt intervent strategi colleg student english learn mix foreign languag teach environ monitor issu tradit teach method current english educ becom evid colleg classroom signific imped innov growth colleg english educ promot develop colleg student around english profici essay focus english learn adapt intervent tactic colleg student use bfltm blend foreign languag teach model studi employ individu center approach choos colleg student primari subject conduct cluster analysi adapt various colleg student english learn base classif indic studi make follow deduct general state student adapt studi english averag intern dimens learn easi adapt averag cognit strategi adapt averag whether averag learn adapt english major signific p signific dimens learn attitud learn interact learn environ p view improv colleg student english learn adapt bfltm paper put forward strategi cultiv student english autonom learn abil creat suitabl classroom atmospher autonom learn establish english autonom learn center virtual communiti | D007802;D007858 | T062;T171;T041;T061 |
36,246,472 | antibiot resist bacteria resist gene isol ghanaian drink water sourc control infecti diseas serious threaten increas number microorgan resist antimicrobi agent antibiot resist bacteria also identifi water environ field studi perform sampl drink water sourc seven district southern ghana target borehol dam hand dug well stream baseflow condit bacteria isol n total water sampl investig antimicrobi suscept determin carriag select antibiot resist gene bacteri identif perform use convent select media method analyt profil index api method antibiot suscept test carri use kirbi bauer method result indic water sourc test poor qualiti base presenc fecal indic organ common occur bacterium isol water klebsiella spp n follow e coli n gram negat bacteria isol common resist cefuroxim gram posit common resist meropenem highest rate bacteri resist one antibiot observ klebsiella spp follow e coli pcr use detect presenc select antibiot resist gene gram negat isol presenc bla ndm sul l tet tet w observ isol water sourc contrast erm f detect gram negat isol water sourc resist gene observ e coli isol reduc microbi contamin various water sourc need protect public health ensur sustain resourc call educ citizenri | D000900;D060766 | T121;T195;T167 |
36,246,471 | public awar matter achiev un sustain develop goal clean water everyon unit nation set sustain develop goal provid clean water everyon sdg success implement sdg still mile go public awar role key factor achiev sustain develop goal vital receiv less attent research past understand role public awar relev factor achiev sdg collect cross section dataset develop countri appli partial least squar structur equat model approach result reveal willing pay clean water social influenc facil provid govern public awar knowledg contamin water posit influenc household intent use clean water also found public awar partial mediat relationship studi result use polici implic govern ngos stakehold organ work achiev sdg develop countri | D000076502;D014867 | T078;T121;T067;T197;T068 |
36,246,470 | spatiotempor relationship ecosystem servic valu ecolog risk disast prone mountain area take upper reach minjiang river exampl mountain area suscept disast frequent occurr disast drive chang ecosystem servic valu esv also bring certain ecolog risk increas incid disast howev scholar investig spatiotempor correl esv disast prone mountain area ecolog risk index eri basin unit paper aim clarifi spatial relationship esv eri chang land use take upper reach minjiang river studi area author collect land use data estim esv valu equival factor per unit area method construct eri basi relationship esv eri investig detail result show follow total esv exhibit fluctuat upward trend spatial distribut esv great affect slope altitud import reason rise esv studi area increas forest area water area upper reach minjiang river general low eri relat good overal ecoenviron howev ecolog risk continu rise strong high risk area area frequent human activ low altitud area river bank spatial correl coupl esv eri studi area ie strong high esv area general low ecolog risk correl intensifi elaps time chang servic valu region ecosystem driven unreason land use great impact ecoenviron clarifi spatiotempor relationship esv eri research provid theoret basi data support formul ecoenvironment restor protect plan upper reach minjiang river coordin develop societi economi ecoenviron region | D004190;D017753 | T082;T070;T067 |
36,246,469 | covid acceler global plastic consumpt implic plastic ingrain societi repercuss usag nonbiodegrad plastic problem recent realiz despit detriment environment impact covid epidem compel worldwid citizen increas plastic use due afford avail volum hospit solid wast particular plastic overgrow due unexpect increas medic wast culmin global wast manag catastroph henceforth adopt good wast manag practic along appropri technolog view current issu fresh perspect would opportun current scenario accord review studi focus plastic wast scenario covid epidem review also dissemin altern dispos option recommend practic solut lessen human relianc tradit plastic respons various legisl regulatori author local region worldwid level address | D000086382;D008506;D018505 | T068;T047;T067;T031 |
36,246,468 | influenc analysi music teach environ monitor student mental health use data mine technolog student current most experi psycholog issu like worri fear primarili brought high demand place one psychotherapi techniqu music therapi goal use music enhanc health particular tool break barrier insid outsid bodi base data mine dm technolog paper examin impact music educ student psycholog health studi demonstr dm algorithm utilis work lowest error rate averag error rate follow aca method averag error rate final ai algorithm averag error rate shown approach suit research effect music instruct student psycholog well function modul base dm develop simul experi confirm applic effect dm algorithm done use data sourc dm structur model mine system build modul foundat origin psycholog evalu system | D008603;D009146 | T170;T041 |
36,246,467 | monitor path select rural public servic environ base data mine technolog new era basic public servic infrastructur rural region lot issu flaw result low effici basic public servic deliveri substanti imped growth rural social economi enhanc farmer qualiti life build smart platform monitor rural public servic environ realis growth rural area creat new socialist countrysid holist ensur sustain stabl healthi develop rural societi great strateg import new circumst essay explor way encourag develop rural public servic platform order choos best cours action rural public servic new era studi studi practic problem rural public servic use dm data mine technolog mine user characterist public servic platform experiment find demonstr algorithm accuraci use techniqu rural public servic may effici mine user characterist offer specif technic support modern day decis maker walk life extraordinari desir inform conceal huge amount data inform age advantag combin two becom wide recognis | D019035 | T058;T073;T093 |
36,246,466 | research injuri caus prevent effect colleg row athlet base multipl regress residu algorithm row competit colleg univers intern competit also favorit competit colleg student howev cours row competit stabil athlet injuri often occur difficult solv effect aim problem loss athlet row competit colleg univers accur prevent paper put forward multipl regress prevent effect model make comprehens analysi combin complex reason integr multipl regress residu analysi better find influenc factor aim find caus athlet injuri put forward correspond countermeasur first analyz caus loss establish framework injuri prevent colleg rower overal diagnosi framework reason accord univers row prevent control standard divid various prevent measur comprehens prevent control measur mechan get caus injuri final optim combin various control measur form control system result matlab show combin multipl regress residu analysi improv accuraci athlet injuri prevent treatment make accuraci shorten diagnosi time less minut meet requir athlet injuri diagnosi normal row competit | D000073678 | T056 |
36,246,465 | analysi nostalgia emot experi rural tourism environ cognit consumpt willing base big data technolog primari research vehicl rural tourism use paper examin urban visitor homesick research explor effect homesick tourist percept travel destin consumpt intent qualit analysi logist empir analysi questionnair survey work also explor behavior trait custom purchas intent perspect big data environ construct relev consumpt behavior model rural visitor accord behavior trait questionnair design investig paper make statist analysi tourist basic inform expect valu actual experi explor relat factor affect consumpt behavior understand consumpt behavior law tourist rural tourism consumpt research show mse mean squar error algorithm rmse root mean squar error algorithm final combin influenc tourist consumpt behavior paper tri put forward countermeasur suggest rural tourism paper aim studi develop plan rural tourist destin provid correspond basi destin select tourist homesick | D000085926;D014195 | T056 |
36,246,464 | monitor model analysi vocal perform teach environ use cluster analysi perspect core literaci cultiv student artist qualiti enhanc vocal music qualiti prepar make great contribut innov develop countri vocal music art main goal open vocal music perform major colleg univers advanc technolog demand talent develop vocal music teach methodolog vocal music perform major colleg univers must continu enhanc otherwis issu disconnect teach style talent develop harm develop high qualiti vocal music talent innov growth vocal music perform major colleg univers vocal music perform major colleg univers activ support reform innov vocal music teach mode order extend student knowledg develop around abil provid strong foundat vocal music perform develop student encompass music abil research suggest design strategi monitor model optim teach environ vocal perform major standpoint core literaci increas effici object cours instruct cluster analysi aid student categoris search vocal music perform main repertoir well use collabor filter recommend locat vocal music perform simul test analysi complet last method certain accuraci higher convent algorithm accord simul find addit signific increas student interest studi vocal music perform cours reform innov teach method cours colleg univers also strengthen student understand various repertoir style signific enhanc music literaci | D000067010;D013334 | T033;T081;T098;T169 |
36,246,463 | empir analysi effect physic exercis adolesc mental health mediat mechan use physic exercis purpos maintain adolesc mental health import topic psycholog research howev unifi conclus effect physic exercis time level mental health paper investig causal effect physic activ adolesc mental health use multilay linear model approach bootstrap method test possibl mediat effect result studi show nonlinear invert u shape relationship physic activ time adolesc mental health threshold valu min result mediat effect analysi show self assess health self confid academ stress peer relationship posit peer behaviour import mediat mechan physic activ mental health result mediat effect analysi show physic exercis import mediat mechan self assess confid academ stress peer relationship posit peer behaviour | D000294;D008603 | T055;T041 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.