PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,367 | spatial genom resourc reveal molecular insight key bioactiv metabolit biosynthesi endang angelica glauca edgew angelica glauca edgew endang medicin aromat herb rich sourc numer industri import bioactiv metabolit includ terpenoid phenol phthalid nevertheless genom intervent sustain util restor genet resourc great offset due scarciti genom resourc key regul under special metabol unravel global atlas special metabol first spatial transcriptom sequenc leaf stem root generat million high qualiti pair end read assembl de novo unigen exhibit signific homolog six public protein databas organ specif cluster group differenti express unigen four subclust differenti enrich leaf stem root tissu predict transcript interactom network integr enrich gene ontolog go kegg metabol pathway identifi key regulatori unigen correspond terpenoid flavonoid carotenoid biosynthesi leaf tissu follow stem root tissu furthermor stem root specif signific enrich phenylalanin ammonia lyas pal cinnam hydroxylas ch caffeic acid methyltransferas comt indic phenylalanin mediat ferul acid biosynthesi stem root howev root specif express nadph depend alkenalon oxidoreductas nadph aor adenosyl l methionin depend methyltransferas sdms polyketid cyclas pkc cypa suggest root primari site phthalid biosynthesi addit gc ms uplc analys correspond organ specif gene express higher content limonen phthalid compound root higher accumul ferul acid stem follow root leaf tissu first comprehens genom resourc array candid gene key metabol pathway potenti util target upscal aromat pharmaceut import bioactiv metabolit also expedit genom assist conserv breed strategi reviv endang glauca | D029969;D061065 | T121;T109;T002 |
36,232,366 | effect age intramuscular connect tissu intramuscular connect tissu play critic role maintain structur integr muscl provid mechan support current studi investig age relat chang may contribut passiv stiff function impair skelet muscl variat extracellular matrix human quadricep femori muscl young men elder male elder femal hindlimb muscl week old month old year old cblj male mice evalu picrosirius red alcian blue weigert van gieson stain perform evalu collagen glycosamynoglycan elast fiber immunohistochemistri analys carri assess collagen collagen iii hyaluronan percentag area collagen signific higher age p lt human p lt mice main due increas collagen differ collagen iii p gt percentag area elast fiber perimysium signific lower p lt elder men togeth signific decreas hyaluronan content human mice signific differ detect accord gender accumul collagen lower level hyaluronan elast fiber age could caus stiffen muscl reduct adapt | D003238;D006820 | T122;T121;T109;T123;T024 |
36,232,365 | elev cerebrospin fluid protein albumin determin poor prognosi spinal amyotroph later sclerosi amyotroph later sclerosi al heterogen diseas onset phenotyp rate progress aim studi establish whether dysfunct blood brain barrier bbb blood spinal cord barrier bscb measur cerebrospin fluid csf protein albumin quotient qalb relat speed diseas progress amount patient diagnos al includ csf serum sampl determin biochem differ paramet surviv analysi base phenotyp show higher probabl death bulbar phenotyp compar spinal phenotyp p valu effect csf protein data show increas risk death spinal al patient valu csf protein increas model replic csf albumin yield similar result statist model determin lowest cut valu csf protein abl differenti patient good prognosi wors prognosi correspond csf protein gl p valu csf albumin qalb associ elev probabl death p valu high level qalb bad prognost indic spinal phenotyp addit high csf protein level also act marker poor prognosi | D000690 | T047 |
36,232,364 | molecular function character short type peptidoglycan recognit protein ct pgrp giant triton snail charonia tritoni peptidoglycan recognit protein pgrps famili pattern recognit receptor prrs involv host antibacteri respons function character invertebr vertebr anim howev littl inform avail regard potenti function pgrps giant triton snail charonia tritoni studi short type pgrp gene term ct pgrp identifi c tritoni ct pgrp predict contain sever structur featur known pgrps includ typic pgrp domain amidas src homolog sh domain ct pgrp gene constitut express tissu examin except probosci highest express level observ liver typic prr ct pgrp abil degrad peptidoglycan pgn proven non zn depend amidas activ antibacteri activ vibrio alginolyticus staphylococcus aureus first report reveal peptidoglycan recognit protein c tritoni result suggest peptidoglycan recognit protein ct pgrp import effector c tritoni modul bacteri infect resist v alginolyticus aureus studi may provid crucial basic data understand innat immun system c tritoni | D010457;D013203 | T047;T109;T123 |
36,232,363 | transcriptom rna base therapeut potenti approach manag sar cov infect sar cov coronavirus famili member appear china decemb caus diseas call covid declar pandem world health organ recent month great effort made field basic clinic research understand biolog infect process sar cov particular transcriptom analysi contribut generat new knowledg viral sequenc intracellular signal pathway regul infect pathogenesi sar cov generat new inform biolog furthermor transcriptom approach includ spatial transcriptom singl cell transcriptom direct rna sequenc use clinic applic monitor detect diagnosi treatment generat new clinic predict model sar cov consequ rna base therapeut relationship sar cov emerg promis strategi battl sar cov pandem assist novel approach crispr cas aso sirna system last discuss import precis public health manag patient infect sar cov establish fusion transcriptom rna base therapeut precis public health allow linkag develop health system facilit acquisit relev clinic strategi rapid decis make assist manag treatment sar cov infect popul combat global public health problem | D000086382 | T047;T067 |
36,232,362 | genom wide associ studi salt toler relat trait germin seedl develop intermedium spike barley collect increas salin one major consequ climat chang affect global crop product earli stage barley hordeum vulgar l life cycl consid critic phase due contribut final crop yield particular germin seedl develop sensit numer environment stress especi soil salin studi aim identifi snp marker link germin seedl develop mm nacl salin treatment perform genom wide associ studi gwas use panel intermedium spike barley h vulgar convar intermedium krn mansf access genotyp data ie snps use genom refer sequenc morex phenotyp result show mm nacl salin treatment signific reduc record germin seedl relat trait compar control treatment furthermor six access hor hor hor hor hor hor identifi salin toler intermedium spike barley collect gwas analysi indic total high signific associ snp marker control andor salin trait identifi two snp marker chromosom chr h two chr h one chr h signific link seedl fresh dri weight salin stress treatment addit two snp marker chr h also signific associ seedl fresh dri weight control condit salin stress one snp marker chr h h h detect one phenotyp trait found access exhibit highest salin toler salin relat qtls present result form basi detail studi lead improv salt toler breed program barley | D001467 | T168;T002 |
36,232,361 | neuroprotect function rasagilin selegilin inhibitor type b monoamin oxidas role monoamin oxidas synucleinopathi synucleinopathi group neurodegen disord caus accumul toxic speci synuclein common clinic featur chronic progress declin motor cognit behavior autonom function includ parkinson diseas dementia lewi bodi multipl system atrophi etiolog clarifi multipl pathogen factor includ oxid stress mitochondri dysfunct impair protein degrad system neuroinflamm current avail therapi prevent progress neurodegener diseas modifi neuroprotect therapi propos paper present molecular mechan neuroprotect inhibitor type b monoamin oxidas rasagilin selegilin prevent mitochondri apoptosi induc anti apoptot bcl protein famili pro surviv brain glial cell line deriv neurotroph factor also prevent toxic oligomer aggreg synuclein monoamin oxidas involv neurodegener neuroprotect independ catalyt activ type monoamin oxidas mediat rasagilin activ signal pathway induc neuroprotect gene neuron cell multi target propargylamin deriv develop therapi various neurodegen diseas preclin studi present neuroprotect rasagilin selegilin benefici effect scarc present strategi improv clinic trial discuss achiev diseas modif synucleinopathi | D019636;D018696;D000080874 | T121;T169;T047 |
36,232,360 | influenc heat treatment surfac structur optic properti nickel copper phthalocyanin thin film work present effect anneal chang polycrystallin phase copper nickel phthalocyanin found process great influenc optic properti vapor deposit layer perform measur show various form mpc valu refract index extinct coeffici increas consequ absorpt coeffici afm imag taken show valu heat morpholog differ raman measur show band cm bg symmetri higher intens form form intens band relat chang form phthalocyanin measur shown chang anneal temperatur layer chang optic properti consequ chang optoelectron paramet adjust requir new optoelectron devic solar cell sensor display ole | D009532;D009942 | T109;T123;T196 |
36,232,359 | striatal neuron partial express dopaminerg phenotyp function signific regul sinc discoveri striatal neuron express dopamin synthes enzym research attempt identifi phenotyp function signific studi shown transgen mice express green fluoresc protein gfp tyrosin hydroxylas th gene promot striatal neuron express th aromat l amino acid decarboxylas aadc enzym dopamin synthesi ii striatal neuron express dopamin synthes enzym dopaminerg sinc lack dopamin transport iii monoenzymat neuron express individu complementari dopamin synthes enzym produc neurotransmitt cooper iv striatal nerv fiber contain th aadc enzym project later ventricl provid deliveri pathway l dihydroxyphenylalanin dopamin cerebrospin fluid v striatal gfp neuron express receptor gene various signal molecul ie classic neurotransmitt neuropeptid steroid indic fine regul neuron base data assum synthesi dopamin striatal neuron compensatori respons death nigral dopaminerg neuron parkinson diseas open broad prospect develop fundament novel antiparkinsonian therapi | D050483;D014446 | T126;T123;T116;T192 |
36,232,358 | fetal program endocrin pancrea impact matern low protein diet gene express perinat rat pancrea rat time birth character transient rise beta cell replic well beta cell neogenesi function matur endocrin pancrea howev knowledg gene express period beta cell expans incomplet aim character perinat rat pancrea transcriptom identifi regulatori pathway differenti regul whole organ level offspr mother fed regular control diet co mother fed low protein diet lp perform mrna express profil via microarray analysi total rat pancrea sampl embryon day e postnat day p co group pancrea metabol pathway relat sterol lipid metabol high enrich wherea lp diet induc chang transcript involv rna transcript gene regul well cell migrat apoptosi moreov number individu transcript mark upregul p co pancrea growth arrest specif gas legumain lgmn et variant gene etv alpha fetoprotein afp dual specif phosphatas dusp angiopoietin like angptl lp diet induc downregul larg number transcript includ neurogenin neurog etv gas dusp signal transduc activ transcript stat growth hormon receptor ghr prolactin receptor prlr gas receptor axl receptor tyrosin kinas axl wherea upregul transcript relat inflammatori respons cell motil identifi differenti regul gene transcript network perinat pancrea data reveal mark adapt exocrin endocrin pancrea low protein diet data contribut identifi novel regul beta cell mass expans function matur may provid valuabl tool generat fulli function beta cell stem cell use replac therapi | D018753;D007515 | T061;T023 |
36,232,357 | uvsora uvsorb involv sorbicillinoid biosynthesi contribut fungal develop stress respons phytotox ustilaginoidea viren ustilaginoidea viren teleomorph villosiclava viren import fungal pathogen caus devast rice diseas produc mycotoxin includ sorbicillinoid biosynthesi biolog function sorbicillinoid report u viren studi identifi sorbicillinoid biosynthet gene cluster two polyketid synthas gene uvsora uvsorb respons sorbicillinoid biosynthesi u viren uvsora uvsorb mutant myceli growth sporul hyphal hydrophob increas dramat resist osmot pressur metal cation fungicid reduc phytotox activ rice germin seed cell wall integr also reduc furthermor mycelia cell wall uvsora uvsorb mutant show alter microscop submicroscop structur addit feed experi show sorbicillinoid could restor myceli growth sporul cell wall integr uvsora uvsorb mutant result demonstr uvsora uvsorb respons sorbicillinoid biosynthesi u viren contribut develop myceli growth sporul cell wall integr stress respons phytotox sorbicillinoid mediat provid insight investig biolog function biosynthesi sorbicillinoid | D005659;D006999;D009183;D012275 | T002;T131;T109;T168;T004 |
36,232,356 | mutat ossac encod xanthin dehydrogenas caus earli senesc rice anim higher plant xanthin dehydrogenas high conserv housekeep enzym purin degrad oxid hypoxanthin xanthin xanthin uric acid previous report demonstr xanthin dehydrogenas play vital role n metabol stress respons xanthin dehydrogenas involv regul leaf senesc recess earli senesc mutant excess sugar accumul ossac isol previous screen em induc mutant librari show xanthin dehydrogenas play role n metabol also involv regul carbon metabol rice base map base clone ossac identifi encod xanthin dehydrogenas ossac constitut express examin tissu ossac protein locat cytoplasm transcript analysi reveal purin metabol chlorophyl metabol photosynthesi sugar metabol redox balanc affect ossac mutant moreov carbohydr distribut chang lead accumul sucros starch leav contain ossac account decreas express ossweeta ossweeta ossweet oxid inactiv starch degrad enzym ossac result indic ossac play vital role leaf senesc regul carbon metabol rice | D012275 | T168;T002 |
36,232,355 | metabol reprogram tumor endotheli cell dynam crosstalk differ compon tumor microenviron critic determin cancer progress metastat dissemin tumor immun therapeut respons angiogenesi critic tumor growth abnorm blood vessel contribut hypoxia acidosi tumor microenviron hostil environ cancer stromal cell abil alter metabol order support high energet demand favor rapid tumor prolifer recent advanc shown tumor endotheli cell metabol reprogram target endotheli metabol pathway impact development patholog vessel sprout therefor use metabol antiangiogen therapi normal blood vasculatur combin immunotherapi offer clinic nich treat cancer | D042783;D009369 | T191;T025 |
36,232,354 | lssmscarlet lssmscarlet chemic stabl genet encod red fluoresc protein larg stoke shift red fluoresc protein larg stoke shift lssrfps genet encod effici excit nm light allow simultan dual color one two photon fluoresc imag fluoresc correl spectroscopi combin green fluoresc protein fps recent base convent bright mscarlet rfp develop lssrfp lssmscarlet lssmscarlet character two pka valu ph valu studi develop improv version lssmscarlet name lssmscarlet lssmscarlet character stoke shift nm extrem ph stabil singl pka valu lssmscarlet lssmscarlet fold faster fold slower matur lssmscarlet respect addit lssrfps fold photost chemic resist denatur guanidinium chlorid guanidinium thiocyan also compar suscept lssmscarlet lssmscarlet lssrfps reagent use whole mount imag expans microscopi immunostain techniqu due higher ph stabil faster matur lssmscarlet lamp fusion fold brighter lssmscarlet lamp lysosom mammalian cell lssmscarlet hlampa fusion similar bright lssmscarlet hlampa lysosom success appli monomer lssmscarlet lssmscarlet protein confoc imag structur protein live mammalian cell also solv x ray structur lssmscarlet protein resolut site direct mutagenesi lssmscarlet protein demonstr key role residu improv ph chemic stabil lssmscarlet protein | D008322;D008853 | T059;T015 |
36,232,353 | variant specif analysi reveal novel long rang rna rna interact sar cov orfa sinc start covid pandem understand patholog sar cov rna virus life cycl prioriti mani research current new variant virus emerg various level pathogen abund within human host popul although much viral pathogen attribut viral spike protein bind affin human lung cell ace receptor comprehens knowledg distinct featur viral variant might affect life cycl pathogen yet attain recent vivo studi rna structur sar cov genom reveal certain long rang rna rna interact use silico predict larg popul sar cov sequenc observ variant specif evolutionari chang certain long rang rris also found statist evid exist one thermodynam base rri predict name comp beta variant sequenc similar test disregard sequenc variant inform howev lead signific result perform popul base analys aggreg test may fail identifi novel interact due variant specif chang variant specif analys result de novo rri identif | D000086382;D000086402 | T047;T067;T005 |
36,232,352 | compar studi al mco ni layer doubl hydroxid silicon foam character flame retard smoke suppress compar differ action two repres transit metal cation co ni layer doubl hydroxid ldhs coal ldh nial ldh intercal co synthes chemic structur microstructur surfac area thereof success character two ldhs util flame retard smoke suppress silicon foam sif densiti flame retard smoke suppress thermal stabil compress strength two sifldh nanocomposit investig introduct ldhs slight decreas densiti sif due catalyt action co ni foam process sif respect flame retard addit phr either coal ldh nial ldh could effect improv limit oxygen index sif base result vertic flame test cone calorimet test flame retard fire safeti sif effect enhanc incorpor ldhs addit owe good catalyt action larg specif surfac area nial ldh g coal ldh g nial ldh reveal higher effici flame retard smoke suppress coal ldh accord result energi dispers x ray spectroscopi co ni particip format protect char layer inhibit releas sio gas phase final influenc thermal decomposit compress strength sif result addit ldhs discuss | D005411;D012906 | T131;T120 |
36,232,351 | triobp protein aggreg exist major depress disord schizophrenia occur two distinct region protein presenc proteinopathi accumul specif protein aggreg neuron emerg aspect patholog schizophrenia major mental ill among initi protein implic form aggreg condit trio f actin bind protein isoform triobp ubiquit express protein involv stabil actin cytoskeleton investig insolubl triobp indic aggreg brain sampl schizophrenia patient major depress disord patient control individu anterior cingul cortex ba strike insolubl triobp consider preval condit control implic triobp aggreg schizophrenia indic role major depress disord result seen use high stringenc insolubl assay previous use studi disc protein lower stringenc assay would expect also detect function actin bound triobp previous also determin region amino acid center protein critic abil form aggreg attempt refin express various truncat mutant triobp vector neuroblastoma cell examin aggreg way possibl narrow aggreg critic region triobp amino acid amino acid long triobp surpris result suggest second section triobp also capabl independ induc aggreg option express amino acid extrem n terminus protein result amino acid long version triobp also refer tara tap reduc potenti form aggreg presenc insolubl triobp brain sampl patient combin insight mechan aggreg triobp generat aggreg resist mutant triobp lack region signific use investig mechan consequ triobp aggreg major mental ill | D003865;D012559 | T048 |
36,232,350 | exosom micro rnas intercellular communic idiopath pulmonari fibrosi communic neighbor distant cell made complex network includ extracellular vesicl ev exosom subgroup ev releas cell type found biolog fluid urin plasma airway secret like bronchoalveolar lavag bal nasal lavag saliva sputum main cargo exosom enrich mrnas microrna mirna transfer recipi cell consequ modifi redirect biolog function effect mirna deriv role gene express regul repress degrad target mrnas nowaday various type research focus evalu potenti exosom mirna biomark prognosi diagnosi differ patholog nevertheless report role pathophysiolog idiopath pulmonari fibrosi ipf chronic lung diseas character progress lung scar cure review focus role effect exosom mirna intercellular communic onset progress ipf well discuss potenti util therapeut agent treatment diseas | D055354;D000067128;D054990;D035683 | T026;T123;T047;T114 |
36,232,349 | current molecular combin therapi use treatment breast cancer breast cancer second lead caus death women worldwid monotherapi singl agent treatment use mani year alway effect mani patient relaps initi treatment moreov patient respons therapi becom weaker resist monotherapi develop time especi problemat metastat breast cancer tripl negat breast cancer recent combin therapi two drug use target two pathway emerg promis new treatment option combin therapi often effect monotherapi demonstr lower level toxic long term treatment review provid comprehens overview current combin therapi includ molecular target therapi hormon therapi immunotherapi chemotherapi also describ molecular basi breast cancer various treatment option differ breast cancer subtyp combin therapi promis also discuss challeng despit challeng use innov combin therapi hold great promis compar tradit monotherapi addit use multidisciplinari technolog nanotechnolog comput technolog potenti optim combin therapi even | D001943;D064726 | T191 |
36,232,348 | whole transcriptom analys apricot japanes plum fruit mcp ethylen inhibitor ethrel ethylen precursor treatment reveal new insight physiolog ripen process physiolog prunus fruit ripen complex complet understood process improv knowledg postharvest behavior shelf life period transcriptom level studi use high throughput sequenc analysi rna seq monitor fruit analyz differ ethylen regul treatment includ mcp ethylen inhibitor ethrel ethylen precursor two contrast select apricot prunus armeniaca l japanes plum p salicina l cultivar goldrich santa rosa keeg protein protein interact network analysi unveil signific metabol pathway involv ripen process photosynthesi plant hormon signal transduct addit previous discov gene link fruit ripen pectinesteras auxin respons protein confirm main gene involv process gene encod pectinesteras pentos glucuron interconvers pathway overexpress speci upregul ethrel hand auxin respons protein iaa aquaporin pip upregul mcp goldrich santa rosa respect result also show upregul chitinas glutaredoxin ethrel treatment goldrich santa rosa respect photosystem subunit v psag photosynthesi upregul mcp speci furthermor overexpress gene encod gdp l galactos ferredoxin ascorb aldar metabol photosynthesi pathway caus mcp favor antioxid activ therefor slow fruit senesc process | D002688;D000068219;D000068242 | T002;T126;T116;T168 |
36,232,347 | stabl magnetorheolog fluid contain bidispers filler compactmesopor silica coat drawback magnetorheolog fluid low kinet stabil sever limit practic util paper describ suppress sediment combin bidispers coat techniqu magnet sub micro addit fabric sequenti coat organosilan first layer repres compact silica outer layer consist mesopor silica obtain oil water biphas stratif method success modif techniqu evidenc transmiss electron microscopi scan electron microscopyenergi dispers x ray spectroscopi fourier transform infrar spectroscopi coat except increas specif surfac area g neat particl g combin lower densiti result remark improv sediment profil expens compactmesopor silica slight diminish magnet particl magnetorheolog perform remain accept level evalu modifi version cross model sediment curv first time magnetorheolog model via novel five paramet equat model show robust fit capabl sub micro addit prevent primari carbonyl iron particl aggreg project improv sediment behavior six fold reduct sediment rate detail focus also given analyz implic sub micro addit surfac textur overal behavior bidispers magnetorheolog fluid | D017646;D012822 | T109;T197 |
36,232,346 | autism spectrum disord associ bacteri metabolit p cresol derail neuroimmun respons microgli cell partial via reduct adam adam bacteri metabolit methylphenol para cresol p cresol deriv p cresyl sulfat p cs elev urin fece children autism spectrum disord asd shown p cresol administr induc social behavior deficit repetit behavior mice howev mechan p cresol specif metabolit p cs reach brain asd remain investig p cs shown inhibit lps stimul inflammatori respons disintegrin metalloproteas adam disintegrin metalloproteas adam thought regul microgli immun respons cleav membran bound protein present studi neuroinflamm model lps activ bv microglia use unveil potenti molecular mechan p cs asd pathogenesi microgli cell p cs treatment decreas express matur adam adam addit p cs treatment attenu tnf il releas well phagocytosi activ microglia vitro adam inhibit experi either adam adam inhibit reduc constitut lps activ releas tnf tnfr il r microgli cell increas constitut lps activ microgli phagocytot activ vivo result confirm involv adam adam asd pathogenesi utero vpa expos male mice elev concentr serum p cresol associ metabolit p cs p cresyl glucuronid p cg associ vpa induc increas adam matur decreas adam matur relat attenu level solubl tnf tgf mice brain overal present studi demonstr partial role adam adam derail innat immun respons microgli cell associ p cs induc asd pathogenesi | D051722;D000067877 | T126;T116;T048 |
36,232,345 | chromosom number rdna loci evolut onobrychi fabacea evolut chromosom number ribosom dna rdna loci number localis studi onobrychi mill diploid tetraploid speci well two basic chromosom number x x observ among analys taxa chromosom distribut rdna loci present first time use fluoresc situ hybridis fish rdna probe onobrychi speci show high polymorph number localis rdna loci among diploid wherea rdna loci pattern similar polyploid phylogenet relationship among speci infer nrit sequenc use framework reconstruct pattern basic chromosom number rdna loci evolut analysi evolut basic chromosom number allow infer x ancestr number descend dysploidi polyploidis major mechan chromosom number evolut analys chromosom pattern rrna gene loci phylogenet context result reconstruct one locus rdna one locus rdna interstiti chromosom posit ancestr state genus | D032461;D007887 | T026;T002 |
36,232,344 | advanc anti cancer activ flavonoid scutellaria radix perspect mechan despit encourag progress develop novel therapi cancer remain domin caus diseas relat mortal becom lead econom healthcar burden worldwid scutellaria radix sr huangqin chines common herb use tradit chines medicin long histori treat seri symptom result cancer like dysregul immun respons metabol abnorm major bioactiv ingredi extract sr flavonoid includ baicalein wogonin along glycosid baicalin wogonosid repres promis pharmacolog anti tumor activ deserv extens research attent emerg evid made great stride elucid multi target therapeut mechan key signal pathway under efficaci potenti flavonoid deriv sr field cancer treatment current review aim summar pharmacolog action flavonoid various cancer vivo vitro moreov also make brief summar endeavor develop drug deliveri system structur modif enhanc bioavail biolog activ flavonoid monom taken togeth flavonoid compon sr great potenti develop adjuv even primari therapi clinic manag cancer promis prospect | D004365;D044950;D009369 | T121;T109;T123;T191 |
36,232,343 | pectobacterium versatil bacteriophag possum complex polysaccharid deacetyl tail fiber tool host recognit pectobacteri schitovirida novel close relat phage possum horatius infect pectobacterium versatil phytopathogen caus soft rot potato essenti plant properti genom composit defin n like bacteriophag genus cbunavirus part recent form famili schitovirida propos adsorpt apparatus phage consist tail fiber connect virion adapt protein tail fiber possess enzymat domain phage possum use deacetyl polysaccharid surfac host strain provid viral attach infect mechan suppos common cbunavirus phage featur consid design cocktail phage control soft rot | D001435;D044043;D017902 | T007;T005 |
36,232,342 | studi long term trace fibroblast three dimension tissu engin scaffold base graphen quantum dot order find conveni stabl way trace human skin fibroblast hsfs three dimension tissu engin scaffold long time experi graphen oxid quantum dot goqd amino graphen quantum dot agqd carboxyl graphen quantum dot cgqds use materi sourc label hsfs explor possibl use long term tracer hsfs three dimension tissu engin scaffold content experi follow hsfs cultur cell cultur medium compos three kind graphen quantum dot h respect use cell count kit cck transwel migrat chamber phalloidin iflior detect effect graphen quantum dot biocompat hsfs use live cell workstat detect fluoresc label result three kind graphen quantum dot hsfs test fluoresc attenu hsfs day hsfs label graphen quantum dot inocul three dimension chitosan demethylcellulos sodium scaffold live cell workstat use detect spatial distribut hsfs three dimension scaffold fluoresc properti hsfs experiment result result cck transwel migrat fitc phalloidin cytoskeleton test show three kind graphen quantum dot effect biolog properti hsfs p lt result fluoresc label experi show agqd could make hsfs fluoresc cell show orang red fluoresc result long rang trace hsfs label agqd show fluoresc life hsfs long day spatial distribut hsfs detect three dimension scaffold base fluoresc properti detect time day | D048271;D006108;D045663 | T121;T109;T196;T073 |
36,232,341 | endometri cell acut expos phthalat vitro phenocopi endometriosi environment factor link increas endometriosi risk includ exposur di ethylhexyl phthalat dehp endocrin disruptor studi aim investig whether dehp vitro exposur primari endometri stromal cell ensc primari endometri epitheli cell enec human endometri adenocarcinoma cell line ishikawa proper mimic alter describ eutop endometrium women endometriosi primari ensc enec isol six fertil egg donor ishikawa cell expos dehp assess viabil endometriosi marker il vegf hoxa ezh lsd steroid receptor gene express er er pr pr b pgrmc invas capac viabil h dehp exposur signific affect none endometriosi marker studi alter acut dehp exposur express steroid receptor invas capac ensc signific increas dehp exposur conclus acut dehp exposur primari endometri cell fulli phenocopi chang viabil express marker steroid receptor describ endometriosi howev signific increas ensc invas observ dehp exposur could link dehp exposur increas endometriosi likelihood | D004051;D052244;D004715;D011987 | T047;T116;T192;T131;T122;T191;T109;T039 |
36,232,340 | proof principl studi suggest potenti anti inflammatori activ butyr propion periodont cell short chain fatti acid scfas potent immun modul present gingiv crevicular fluid therefor like scfas exert role periodont health diseas better understand scfas modul inflamm screen acet acid propion acid butyr acid potenti abil lower inflammatori respons macrophag gingiv fibroblast oral epitheli cell vitro end raw primari macrophag expos lpss porphyromona gingivali p gingivali without scfas moreov gingiv fibroblast hsc oral epitheli cell expos il tnf without scfas report butyr effect reduc lipopolysaccharid lps induc express il chemokin c x c motif ligand cxcl raw primari macrophag butyr also reduc il tnf induc express il chemokin c x c motif ligand cxcl cxcl gingiv fibroblast likewis butyr lower induc express cxcl cxcl il hsc cell butyr caus reduct p nuclear transloc raw macrophag gingiv fibroblast hsc cell propion acet partial lower inflammatori respons vitro reach level signific find suggest macrophag also gingiv fibroblast oral epitheli cell suscept anti inflammatori activ butyr | D011422;D014409 | T121;T109;T116;T129 |
36,232,339 | high resolut conform analysi rgdechi deriv peptid base combin nmr spectroscopi md simul crucial role integrin patholog process tumor progress metastasi format inspir intens effort design novel pharmaceut agent modul integrin function order provid new tool potenti therapi past decad investig biolog proprieti chimer peptid rgdechi contain cyclic rgd motif link echistatin c termin fragment abl specif recogn v without cross react v iib integrin addit demonstr use two rgdechi deriv peptid call rgdechi rgdechi chemic modif introduc c termin part peptid alter abolish bind v integrin shed light structur dynam determin involv integrin recognit mechan investig effect chemic modif explor conform space sampl rgdechi rgdechi use integr natur abund nmrmd approach data demonstr flexibl rgd contain cycl driven echistatin c termin region rgdechi peptid coupl mechan n c termin region | D039302;D010455 | T121;T116;T192 |
36,232,338 | antiag activ phytochem dark color plant food involv autophagi apoptosi associ pathway last two decad human life expect increas year accompani correspond increas healthi lifespan age associ wide rang human disord includ cancer diabet cardiovascular neurodegen diseas delay age organ tissu improv physiolog function elder reduc risk age relat diseas autophagi apoptosi crucial mechan cell surviv tissu homeostasi may also primari age regulatori pathway recent epidemiolog studi shown eat color plant food could increas life expect sever repres phytochem dark color plant food quercetin catechin curcumin anthocyanin lycopen appar antiag potenti nevertheless antiag signal pathway phytochem dark color plant food remain elus present review summar autophagi apoptosi associ target pathway phytochem discuss core target involv antiag effect clinic evalu exploit phytochem antiag agent need develop novel antiag therapeut prevent age relat diseas improv healthi lifespan | D002392;D003474 | T121;T109;T130 |
36,232,337 | viscer adipos tissu molecular network regulatori microrna pediatr obes silico approach childhood obes carri increas risk metabol complic sleep disturb cancer viscer adipos independ associ inflamm insulin resist obes children howev under pathogen mechan still unclear aim detect gene express pattern regulatori network viscer adipos tissu obes pediatr individu use differenti express gene deg identifi two public avail dataset gse gse perform function enrich protein protein interact network analys identifi pathway target transcript factor tfs microrna mirna regulatori network overlap deg six signific cluster candid hub gene furthermor tfs target hub gene gene regul mir p mir p mir p mir top mirna accord maximum number mirna mrna interact pair mirna signific enrich sever pathway includ lipid metabol immun respons vascular inflamm brain develop associ prediabet diabet nephropathi depress solid tumor multipl sclerosi gene mirna detect studi involv pathway diseas relat obes obes associ complic result emphas import tgf signal pathway regulatori molecul immun system adipocyt apoptot pathway pediatr obes network associ condit molecular mechan potenti regul contribut pathogenesi open investig | D035683;D063766 | T047;T123;T033;T114 |
36,232,336 | non pharmacolog therapeut option treatment alzheim diseas alzheim diseas grow global crisi need urgent diagnost therapeut strategi current treatment strategi most involv immunotherapeut medic littl success halt diseas progress hypothes pathogenesi develop ad expand implic organ system well cellular reaction non pharmacolog intervent rang minim deepli invas attempt address divers contributor ad review aim delin mechan under intervent attempt provid explanatori link observ differ diseas state postul metabol structur mechan chang techniqu discuss exhaust list non pharmacolog intervent ad provid foundat facilit deeper understand area studi | D000544 | T047;T048 |
36,232,335 | immun state convers mesenter lymph node mous breast cancer model secondari lymphoid tissu spleen lymph node lns contribut breast cancer develop metastasi anti pro tumor direct although secondari lymphoid tissu extens studi littl known immun convers mesenter lns mlns breast cancer develop demonstr inflammatori immun convers mlns metastat breast cancer model splenic cell signific decreas continu suppress ifn product tumor develop myeloid deriv suppressor cell mdscs dramat enrich howev cell number mln decreas mdscs moder increas cell mln exhibit convers pro inflammatori state high ifn express anti inflammatori state high express il il earli late stage breast cancer develop interest increas migrat cd cdb dendrit cell dcs mln along increas glucan level serum observ even late stage breast cancer suggest cd cdb dcs could prime cancer reactiv cell togeth data indic mln import lymphoid tissu contribut breast cancer develop | D001943;D016753;D009369 | T191;T116;T129 |
36,232,334 | protein fatti liver diseas hepatocellular carcinoma non alcohol fatti liver diseas nafld high preval slow progress hepat patholog character differ stage increas sever ultim give rise develop hepatocellular carcinoma hcc besid drastic lifestyl chang drug effect extent allevi nafld hcc remain poor curabl cancer among deregul molecular mechan promot nafld hcc sever member protein famili appear play import role develop hepat steatosi non alcohol steatohepat nash hcc specif member ca bind protein famili inde signific overexpress either parenchym non parenchym liver cell exert pleiotrop patholog function drive nafldnash sever stage andor cancer develop aberr activ specif isoform also report drive malign liver cancer herein discuss implic sever key member famili eg sa sa sa sa sa nafld hcc particular focus intracellular versus extracellular function differ hepat cell type clinic relev non invas diagnosticprognost biomark differ stage nafld hcc pharmacolog target therapeut purpos debat | D006528;D008113;D065626 | T191;T047 |
36,232,333 | differ format reactiv oxygen speci cytotox thiol combin aqua cyanocobalamin cobalamin essenti nutrient requir normal function cell defici lead various patholog state hydroxocobalamin hocbl cyanocobalamin cncbl form vitamin b common use supplement substanti evid indic cobalamin suppress promot oxid stress howev mechan under effect poor understood shown oxid thiol catalyz hocbl cncbl accompani reactiv oxygen speci ros product induc certain condit oxid stress cell death form vitamin b structur thiol play decis role process found mechan kinet thiol oxid catalyz hocbl cncbl differ substanti hocbl increas rate oxid thiol greater extent cncbl quench ros combin certain thiol oxid catalyz cncbl general slower yet absenc ros quench result higher accumul aforement result might explain pronounc cytotox induc combin thiol cncbl whole data obtain provid new insight redox process cobalamin involv result might also help develop new approach treatment cobalamin respons disord oxid stress import compon | D006879;D014805 | T121;T109;T127;T114 |
36,232,332 | neomycin interfer phosphatidylinositol bisphosph yeast plasma membran activ cell wall integr pathway cell wall integr pathway cwi mapk mediat signal rout essenti yeast cell respons cell wall damag regul distinct aspect fungal physiolog recent proven incorpor genet circuit oper signal amplifi pathway allow identif novel element involv cwi signal show strong growth inhibit trigger pathway hyperactiv cell carri integr pathway activ circuit ipac also allow easi identif new stimuli use ipac found various chemic agent activ cwi pathway includ aminoglycosid neomycin cell lack key compon pathway sensit antibiot due disrupt signal upon neomycin stimul neomycin reduc phosphatidylinositol bisphosph pip avail plasma membran myriocin induc torc depend ypk phosphoryl suggest strong interfer plasma membran homeostasi specif pip neomycin induc transcript profil involv gene relat stress cell wall biogenesi also amino acid metabol reflect action antibiot yeast ribosom | D012441;D029701 | T116;T004 |
36,232,331 | tumor intrins pd l exert oncogen function activ wnt catenin pathway human non small cell lung cancer program death ligand pd l strong inhibit cell activ therebi aid tumor escap immun respons pd l inhibitor proven effect treatment differ type cancer includ non small cell lung cancer nsclc yet knowledg regard biolog function tumor intrins pd l lung cancer remain obscur studi set goal determin function pd l use overexpress knockdown strategi pd l silenc result decreas migratori invas abil tumor cell togeth attenu coloni form capac ectop express pd l show opposit effect along increas activ mapk wnt catenin pathway upregul wnt catenin target gene addit overexpress pd l associ dysregul cellular exosom mirna involv tumor progress metastasi primari lung tumor immunohistochemistri reveal pd pd l high express squamous cell carcinoma scc compar adenocarcinoma p p respect scc pd express signific associ tumor grade p taken togeth data suggest pd l may exert oncogen function nsclc activ wnt catenin signal may act potenti diagnost marker lung scc | D002289;D002294;D008175;D035683 | T191;T123;T114 |
36,232,330 | iron deposit ferroptosi spleen murin model acut radiat syndrom total bodi irradi tbi result death associ hematopoiet insuffici although radiat caus apoptosi white blood cell red blood cell rbc undergo hemolysi due hemoglobin denatur rbc lysi post irradi result releas iron plasma produc secondari toxic event investig radiat induc iron spleen mice follow tbi effect radiat mitig captopril rbc hematocrit reduc day nadir day post tbi prussian blue stain reveal increas splenic fe alter express iron bind transport protein determin qpcr western blot immunohistochemistri captopril affect iron deposit spleen modul iron bind protein caspas activ day indic apoptosi occur also identifi marker iron depend apoptosi known ferroptosi pwaf acceler senesc marker upregul macrophag inflamm effect tbi investig effect radiat fe ja murin macrophag cell line radiat induc pwaf ferritin caspas h radiat iron upregul sever marker pro inflammatori polar radiat iron also upregul marker anti inflammatori polar data indic follow tbi iron accumul spleen regul iron bind protein trigger apoptosi possibl ferroptosi | D054508;D000079403 | T043;T037 |
36,232,329 | anticanc therapeut strategi target p aggreg p tumor suppressor protein mutat cancer case mutat frequent result p oncogen gain function gof result greater tendenc aggreg phase separ phase transit pathway gof relat p aggreg includ chemoresist make therapi even difficult therapi avail treatment cancer still quit limit studi new molecul therapeut target focus p aggreg promis strategi cancer review classifi anticanc molecul antiaggreg properti four categori thiol alkyl agent design peptid agent chaperon base mechan inhibit p aggreg miscellan compound anti protein aggreg properti studi neurodegen diseas furthermor highlight autophagi possibl degrad pathway aggreg p consid cancer protein aggreg diseas review strategi use disrupt p aggreg lead cancer regress | D009369;D016159 | T191;T123;T116 |
36,232,328 | equip sexual sting male specif venom peptid euscorpius italicus anim kingdom intraspecif variat occur exampl popul differ life stage sex venom anim involv differ venom composit case venom util context mate differ composit might driven sexual select regard genus euscorpius promis group research scorpion exhibit distinct sexual dimorph known perform sexual sting mate howev venom composit genus remain larg unexplor demonstr euscorpius italicus exhibit male specif venom composit identifi larg fraction substanc involv sex specif venom peptid first determin analyz presenceabs pattern ion signal maldi tof mass spectra venom sampl sex juvenil subsequ proteo transcriptom analysi provid sequenc inform relev venom peptid correspond precursor result show sever potenti toxin precursor regul male venom gland possibl reduc toxic effect caus femal sexual sting identifi precursor one promin male specif venom peptid may ideal candid activ test futur studi addit descript male specif featur venom e italicus studi also includ general survey venom precursor speci | D001733;D012604 | T131;T123;T116;T037 |
36,232,327 | control photophys behavior rhenium complex di thiazol yl pyridin base ligand pendant conjug aryl group structur properti correl control electron excit state transit metal complex tmcs high signific tmc base function materi develop within studi seri carbonyl complex aryl substitut di thiazol yl pyridin ar n dtpi synthes ground excit state properti investig number condens aromat ring function link mode aryl substitu play fundament role control photophys result recl co ar n dtpi n photoexcit recl co ar n dtpi n naphthyl naphthyl phenanthrenyl lead popul mlct lowest triplet state chromophor bear anthryl anthryl pyrenyl group ligand local rhenium complex append pyrenyl group featur long live room temperatur emiss attribut equilibrium mlct il ilct excit state dynam complex recl co anthryl dtpi n recl co anthryl dtpi n strong depend electron coupl anthracen recl co dtpi n less steric hindranc chromophor recl co anthryl dtpi n respons faster format il ilct larger contribut ilct anthracen dtpi relat isomer complex recl co anthryl dtpi n agreement stronger electron communic aryl coordin centr recl co anthryl dtpi n display room temperatur emiss contribut mlct il anthracen ilct anthracen dtpi phosphoresc latter present rare observ phenomena luminesc metal complex | D056831;D012211 | T104;T196 |
36,232,326 | age associ loss renal nestin posit progenitor cell decreas number resid progenitor cell age shown sever organ loss associ declin regen capac greater vulner organ injuri howev experi evalu number progenitor cell kidney age perform recent studi tri address chang number renal progenitor cell age experi carri young old transgen nestin green fluoresc protein gfp report mice sinc nestin suggest one marker progenitor cell found nestin cell kidney tissu locat putat nich resid renal progenitor cell evalu amount nestin cell kidney differ age reveal multifold decreas level nestin cell old mice vitro experi primari cultur renal tubular cell show cell includ nestin cell old mice lower prolifer rate moreov resist damag factor reduc cell obtain old mice data indic loss resid progenitor cell kidney decreas renal cell prolif capac age | D007668;D013234 | T023;T025;T081 |
36,232,325 | dlmam deep learn base tool identifi n dimethyladenosin site rna sequenc n dimethyladenosin post transcript modif may associ regulatori role control cellular function therefor crucial accur identifi transcriptom wide site understand under depend mrna regul mechan biolog function use three sequenc base featur encod scheme includ one hot nucleotid chemic properti ncp nucleotid densiti nd repres rna sequenc sampl addit propos ensembl deep learn framework name dlmam identifi site dlmam consist three similar base classifi contain multi head attent modul embed modul two parallel deep learn sub modul convolut neural network cnn bi direct long short term memori bilstm predict modul demonstr superior perform model architectur compar multipl model framework method analyz train data independ test data addit compar model exist state art comput method mampr multirm accuraci acc dlmam model improv compar mampr multirm independ test data respect area receiv oper characterist curv auroc dlmam model increas respect result indic dlmam achiev best predict perform term acc matthew correl coeffici mcc auroc area precis recal curv aupr assess general perform propos model implement chromosom level leav cross valid found obtain auroc valu greater indic propos method robust accur predict site | D000465;D000077321 | T170;T066 |
36,232,324 | intermolecular interact evolv nemat twist bent phase transit polar beam infrar ir spectroscopi provid valuabl inform chang orient sampl nemat phase especi role intermolecular interact form period modul twist bent phase infrar absorb measur quantum chemistri calcul base densiti function theori dft perform investig structur molecul interact nemat n twist bend n tb phase thioether dimer nemat twist bend phase observ signific chang mean ir absorb cool transit n phase n tb phase found accompani mark decreas absorb longitudin dipol cool absorb transvers dipol increas indic transvers dipol becam correl parallel investig influenc closest neighbor dft calcul perform result optim molecular core system observ chang squar transit dipol well correspond absorb chang observ ir spectra interact molecul domin pair observ well axial shift core | D050866 | T104;T073 |
36,232,323 | role phosphorus nitrogen nutrient transport arbuscular mycorrhiz symbiosi land plant speci form symbios arbuscular mycorrhiz fungi nutrient transfer plant larg mediat partnership last year great progress made deciph molecular mechan under mediat modul nutrient uptak progress grow number fungal plant gene respons uptak nutrient soil transfer across fungal root interfac identifi review outlin current concept nutrient exchang within symbiosi mechan regul focus p n transfer fungal partner host plant highlight possibl interplay p n nutrient exchang transport belong plant fungi synergist process transmembran transport soil nutrient symbiot interfac plant acquisit although much progress made elucid complex mechan integr role nutrient transfer symbiosi question still remain answer exampl p n transport less studi differ speci fungi involv fungi plant n uptak clear defin p coordin util n p unknown transport cultiv plant inocul fungi transcriptom metabolom network soil fungi interfac fungi plant interfac insuffici studi find open new perspect fundament research applic fungi agricultur | D038821;D010758 | T196;T004;T197 |
36,232,322 | gsttgstm genotyp anti tuberculosi drug induc hepatotox peruvian patient peru peopl diagnos tuberculosi tb although tb treatment effect associ signific advers drug reaction adr drug induc liver injuri dili consid predomin among first line antituberculosi drug isoniazid inh main drug respons appear dili liver inh metabol enzym n acetyltransferas nat cytochrom p e cype glutathion transferas gst two isoform gstt gstm base previous studi hypothes interact gstt gstm null genotyp induc dili tb patient cross section studi particip complet anti tb treatment genotyp reveal presenc absenc bp band gstm gstt respect found preval gstm genotyp presenc null respect gstt presenc null respect neither genotyp preval patient develop dili n confirm hypothesi howev found combin gstm present genotyp gstt null genotyp fast nat acetyl cype cc genotyp signific risk develop adr p ci propos presenc gstm present genotyp gstt null genotyp fast nat acetyl cype cc genotyp peruvian popul could consid risk factor develop adr due therapeut drug intak | D001191;D056486;D014376 | T047;T126;T116;T037 |
36,232,321 | chronic ethanol consumpt alter presynapt regul dorsal striatal dopamin releas cblj mice alcohol use disord aud character escal alcohol consumpt preoccup alcohol continu alcohol consumpt despit advers consequ dopamin implic neural behavior process involv reward reinforc critic neurotransmitt aud clinic preclin research shown long term ethanol exposur alter dopamin releas though work focus nucleus accumben nac like nac dorsal striatum ds implic neural behavior process aud howev littl work examin chronic ethanol effect ds dopamin dynam therefor examin effect ethanol consumpt withdraw dopamin releas presynapt regul fast scan cyclic voltammetri cblj mice found one month ethanol consumpt alter maxim dopamin releas dopamin tissu content howev find dopamin autoreceptor sensit also found decreas cholinerg control dopamin releas via contain nachr dopamin axon interest effect revers follow withdraw rais possibl neuroadapt aud might revers abstin altogeth work elucid chronic alcohol induc neurobiolog dysfunct dopamin system | D017660;D004298 | T116;T192;T121;T109;T123 |
36,232,320 | molecular mechan under ca calmodulin depend protein kinas kinas signal transduct ca calmodulin depend protein kinas kinas camkk activ kinas multipl downstream kinas includ cam kinas camki cam kinas iv camkiv protein kinas b pkbakt amp kinas ampk phosphoryl activ loop thr residu respons increas intracellular ca concentr camkk ca cam depend enzym camkk mediat kinas cascad play import role number ca depend pathway neuron morphogenesi plastic transcript activ autophagi metabol regul well pathophysiolog pathway includ cancer progress metabol syndrom mental disord review focus molecular mechan under camkk mediat signal transduct normal pathophysiolog condit summar current knowledg structur function physiolog properti regulatori kinas camkk develop applic pharmacolog inhibitor | D054737;D051057 | T121;T126;T116 |
36,232,319 | synthesi silver nano particl use myricetin vitro assess anti colorect cancer activ silico integr creation novel anticanc treatment varieti human ill includ differ malign danger microb also potenti depend nanoparticl includ silver recent success biolog synthes metal nanoparticl use plant extract natur flavonoid hexahydroxyflavon myricetin anticanc properti much known regulatori effect myricetin possibl cell fate determin mechan apoptosisprolifer colorect cancer major investig relat anticanc activ myricetin domin focus enhanc tumor cell uncontrol growth ie apoptosi thus decid explor potenti myricetin interactor associ biolog function use silico approach focus main goal work involv synthesi silver nanoparticl label myricetin synthes silver nanoparticl examin use uv visibl spectroscopi dynam light scatter spectroscopi fourier transform infrar spectroscopi scan electron microscopi studi investig effect myricetin colorect cancer numer techniqu use show myricetin effect colon cancer cell transmiss electron microscopi employ monitor morpholog chang furthermor combin result colorect cancer gene express dataset myricetin interactor pathway base result conclud myricetin abl effici kill human colorect cancer cell line sinc share import biolog role possibl rout compon myricetin may promis herbal treatment colorect cancer per silico analysi tcga dataset | D000970;D053768;D009369 | T121;T109;T073;T191 |
36,232,318 | infiltr apoptot macrophag subpopul negat correl immunotherapi respons colorect cancer polar tumor associ macrophag tam play key role tumor develop immunotherapi colorect cancer crc patient howev impact apoptosi tam polar immunotherapi efficaci patient differ mismatch repair status mmr remain unclear construct atlas macrophag found higher rate infiltr like tam subpopul pmmr crc tumor tissu compar dmmr crc tumor tissu import lower infiltr rate mc like tam associ immunotherapi respons polar trajectori reveal apoptosi mc like tam dmmr differenti mc like tam pmmr impli higher polar level pmmr furthermor found high express sa induc apoptosi mc like tam dmmr conclus identifi apoptot tam subpopul polar trajectori found apoptosi caus high express sa reduc infiltr tumor well level polar contribut favor immunotherapi respons find provid new insight potenti role apoptosi suppress tumor enhanc immunotherapeut efficaci | D003110;D015179 | T191 |
36,232,317 | novel protein adamt promot gastric carcinogenesi target ifi nf b signal pathway disintegrin metalloproteinas thrombospondin motif adamt report involv pathogenesi solid cancer howev role gastric cancer gc unclear studi role adamt gastric cancer investig effect adamt cell migrat invas prolifer investig function experi vivo vitro downstream signal pathway adamt confirm use bioinformat analysi co immunoprecipit immunofluoresc meanwhil bioinformat analysi qrt pcr western blot dual luciferas report gene analysi assay use identifi adamt target express adamt gc analyz public dataset express adamt correl clinic characterist gc investig immunohistochemistri ectop adamt express signific promot tumor cell migrat invas growth bioinformat analysi western blot show adamt upregul ifi protein nf b pathway confirm immunofluoresc western blot dual luciferas report gene analysi identifi bind site p ifi may direct involv transcript regul ifi ifi knockdown revers promot effect adamt cell invas migrat prolifer indic adamt act gc cell target nf bifi axi adamt associ poor prognosi clinic characterist adamt promot cell migrat invas prolifer target ifi nf b pathway potenti progress surviv biomark gc | D035683;D013274 | T191;T123;T114 |
36,232,316 | dri bilberri vaccinium myrtillus l allevi inflamm advers metabol effect caus high fat diet mous model obes obes increas problem worldwid often associ co morbid type ii diabet atherosclerot diseas non alcohol fatti liver diseas risk diseas lower reliev system low grade inflamm associ obes even without notic weight loss bilberri anthocyanin rich wild berri known antioxid anti inflammatori properti present studi high fat diet induc mous model obes use investig effect air dri bilberri powder weight gain system inflamm lipid glucos metabol chang gene express adipos hepat tissu bilberri supplement unabl modifi weight gain prevent increas hepat injuri marker alt mani inflammatori factor like saa mcp cxcl induc high fat diet bilberri supplement also partial prevent increas serum cholesterol glucos insulin level conclus bilberri supplement allevi system hepat inflamm retard develop unwant chang lipid glucos metabol induc high fat diet thus bilberri supplement seem support retain healthier metabol phenotyp develop obes effect might contribut bilberri anthocyanin | D003924;D061385;D029800 | T121;T047;T168;T002 |
36,232,315 | human cytomegalovirus long non code rna prevent induct reactiv oxygen speci maintain viral gene silenc latenc human cytomegalovirus hcmv signific sourc diseas immunosuppress immunona treatment hcmv made problemat viral latenc lifecycl stage virus reduc gene express produc infecti virus high express viral gene hcmv latenc viral long non code rna although recent shown lncrna lower level reactiv oxygen speci ros infect monocyt impact latenc unclear show import establish maintain hcmv latenc aid suppress viral lytic gene express direct relat abil quench reactiv oxygen speci ros consist also find exogen induc ros caus reactiv latent hcmv effect compens treatment antioxid lower ros level final show ros mediat reactiv independ myeloid differenti instead reli nf b activ altogeth result reveal novel factor central complex process underpin hcmv latenc find may particular relev transplant set transplant tissueorgan subject high ros level hcmv reactiv pose signific threat | D003587;D062085 | T123;T005;T114 |
36,232,314 | galectin potenti therapeut target neurodegen disord advanc medicin increas longev human result higher incid chronic diseas due rise elder popul age depend neurodegen disord becom increas preval avail treatment option provid symptomat relief cure under caus diseas therefor becom imper discov new marker therapi modul cours diseas progress develop better treatment option affect individu grow evid indic neuroinflamm common factor one main induc neuron damag degener galectin gal class galactosid bind protein lectin ubiquit express almost vital organ gal modul various cellular respons regul signific biolog function includ immun respons prolifer differenti migrat cell growth interact glycoprotein glycolipid recent year extens research conduct gal superfamili gal gal gal prime focus role describ modul neuroinflamm neurodegen process review discuss role gal causat progress neurodegen disord describ role gal microglia astrocyt modul along pro anti inflammatori function addit discuss potenti use gal novel therapeut target neuroinflamm restor tissu damag neurodegen diseas | D037161;D019636 | T047;T123;T116 |
36,232,313 | possibl connect two dual function process relationship ferroptosi jnk pathway ferroptosi repres typic process dual function cell fate decis sinc reduct andor inhibit ferroptosi desir therapi diseas neurolog disord local ischemia reperfus kidney injuri hematolog diseas enhanc ferroptosi cancer cell may benefit patient cancer jnk pathway also real dual function fate cell multipl factor suggest potenti link ferroptot jnk pathway process ros mediat ii inhibit lipid peroxid scaveng iii ras mutat may play role initi pathway aim investig possibl link ferroptosi jnk pathway interest jnk inhibitor co treatment could enhanc cancer cytotox effect ferroptosi induc nras kras mutat harbor cell ht mia paca sinc cancer cytotox effect jnk inhibitor could suspend ferroptosi inhibitor sole jnk inhibitor treatment affect cell viabil seem jnk inhibitor amplifi effect ferroptosi induc cancer cell death amplifi effect jnk inhibitor could observ oxid stress driven cell death henc seem specif ferroptosi final result suggest gsh contentdeplet could import candid switch anti cancer effect jnk inhibitor | D000970;D000079403;D009369 | T121;T043;T109;T191 |
36,232,312 | molecular mechan anti inflammatori phytochem natur occur bioactiv also known phytochem wide recogn research owe multipl potenti | D000893;D064209 | T121;T109;T123 |
36,232,311 | virtual screen quantum chemistri analysi sar cov rna depend rna polymeras use chembl databas reproduct remdesivir rtp favipiravir rtp bind mode obtain cryo em experi high bind affin novel coronavirus sever acut respiratori syndrom coronavirus sar cov identifi pathogen caus coronavirus diseas covid rna depend rna polymeras rdrp sar cov potenti target treatment covid rdrp complex dsrna structur suitabl dock simul prepar use cryo electron microscopi cryo em structur pdb id aap resolut report recent structur refin perform use energi calcul structur base virtual screen perform use chembl databas screen drug approv clinic preclin drug predict exhibit high bind affin rdrp complex dsrna nine nucleosid triphosph analog anti viral activ includ among hit drug among remdesivir ribonucleosid triphosph favipiravir ribonucleosid triphosph adopt similar dock mode observ cryo em structur addit dock simul predict compound high bind affin rdrp complex dsrna suggest bioactiv compound could anti sar cov drug candid hit bioactiv compound main consist typic noncoval major groov binder dsrna three layer oniom mp g amber geometri optim calcul frequenc analys mp g amber perform estim bind free energi repres bioactiv compound obtain dock simul fragment molecular orbit calcul mp g level theori subsequ perform analyz detail interact procedur use studi repres possibl strategi discov anti sar cov drug drug librari could signific shorten clinic develop period drug reposit | D000086382;D012263 | T047;T067;T114 |
36,232,310 | valor polyethylen terephthal mucon acid engin pseudomona putida plastic wast rapid accumul environ becom huge global challeng mani studi highlight role microbi metabol engin valor polyethylen terephthal pet wast studi propos new conceptu scheme upcycl pet construct multifunct pseudomona putida kt simultan secret pet hydrolas lcc leaf branch compost cutinas synthes mucon acid use pet hydrolys final product extracellular lcc separ supernat cultur ultrafiltr latter use next round pet hydrolysi total g produc g pet cycl whole biolog process reach theoret convers new conceptu scheme valor pet wast advantag exist pet upcycl scheme provid new idea util macromolecular resourc difficult decompos lignin | D016958 | T007 |
36,232,309 | effect cigarett smoke exposur gut microbiota liver transcriptom mice reveal gut liver interact cigarett smoke exposur harm impact health increas risk diseas howev studi cigarett smoke induc advers effect perspect gut liver axi lack studi evalu advers effect cigarett smoke exposur mice physiolog biochem histopatholog analys explor cigarett smoke induc gut microbiota imbal chang liver gene express multiom analysi demonstr cigarett smoke exposur caus abnorm physiolog indic includ reduc bodi weight blood lipid food intak mice also trigger liver injuri induc disord gut microbiota liver transcriptom especi lipid metabol signific correl intestin bacteri abund express lipid metabol relat gene detect suggest coordin regul lipid metabol gut microbiota liver metabol specif salmonella harm bacterium negat posit correl acsl downregul gene angptl cypaa plin involv lipid metabol ligilactobacillus benefici bacterium show opposit trend gene result clarifi key role gut microbiota liver damag metabol improv understand gut liver interact caus cigarett smoke exposur | D000073865;D000069196 | T007;T055;T001 |
36,232,308 | role endothelin right atrial arrhythmogenesi rabbit monocrotalin induc pulmonari arteri hypertens atrial arrhythmia consid promin phenomena pulmonari arteri hypertens pah result atrial electr structur remodel endothelin et level correl pah sever associ atrial remodel arrhythmia studi hemodynam measur western blot analysi histopatholog perform control monocrotalin mct mgkg induc pah rabbit convent microelectrod use simultan record electr activ isol sinoatri node san right atrium ra tissu prepar et nm bq et receptor antagonist nm perfus mct treat rabbit show increas relat wall thick pulmonari arteriol mean cell width cross section area rv myocyt higher right ventricular systol pressur deem pah compar control spontan beat rate san ra prepar faster mct induc pah group slow et mct induc pah rabbit higher incid sinoatri conduct block et induc atrial prematur beat short run intra atrial reentrant tachycardia bq administr mitig et induc ra arrhythmogenesi mct induc pah ra specimen mct induc pah rabbit smaller connexin larger rock phosphoryl akt control similar pkg akt control conclus et act trigger factor interact arrhythmogen substrat initi maintain atrial arrhythmia pah et et receptorrock signal may target therapeut intervent treat pah induc atrial arrhythmia | D016686;D000081029 | T047;T109;T131 |
36,232,307 | target specif machin learn score function improv structur base virtual screen perform sar cov drug develop leverag machin learn shown improv accuraci structur base virtual screen furthermor tremend amount empir data public avail enhanc perform machin learn approach proof concept studi cl pro enzym sar cov use structur base virtual screen reli heavili score function wide accept target specif score function may perform effect univers score function real world drug research develop process would benefici drug discoveri develop method effect build target specif score function current studi bindingdb databas use retriev experiment data smina util generat protein ligand complex extract interactionfingerprint ifp simpleinteractionfingerprint sifp fingerprint via open drug discoveri tool oddt present studi found randomforestclassifi randomforestregressor perform well use fingerprint along molecular access system macc extend connect fingerprint ecfp ecfp found area precis recal curv consid satisfactori level accuraci addit enrich factor analysi indic train score function rank molecul correct compar smina generic score function molecular dynam simul indic top rank molecul identifi develop score function high stabl activ site support valid develop process research may provid templat develop target specif score function specif enzym target | D000086382;D000086402 | T047;T067;T005 |
36,232,306 | copper ii replac structur zinc ion prokaryot zinc finger ros result function domain strict interplay known involv copper zinc mani cellular process reason result copper interact zinc bind protein great interest instanc copper interfer dna bind activ zinc finger protein associ develop varieti diseas biolog impact copper depend chemic properti two common oxid state cu cu ii framework follow attent address unveil effect metal ion replac zinc finger zinc contain protein explor effect zn ii cu cu ii replac prokaryot zinc finger domain prokaryot zinc finger protein ros involv horizont transfer gene tumefacien host plant infect belong famili protein name rosmucr whose member recogn differ bacteria symbiont pathogen mammal plant interest amino acid coordin sphere poor conserv protein although sequenc ident high fact member famili protein bind zinc metal assum structur similar ros residu replac zinc ligand form network hydrogen bond hydrophob interact surrog zn coordin role peculiar featur ros zf domain prompt us studi metal ion replac ion differ electron configur ionic radius protein intens studi perfect suit model metal bind protein studi effect metal ion replac appear toler zn cd substitut replac wildtyp metal ni ii pb ii hg ii structur character report give high resolut descript interact copper ros demonstr copper oxid state bind protein replac give rise function domain | D008628;D015032 | T121;T131;T196;T123 |
36,232,305 | role exosom health diseas would thought discoveri made research washington univers | D055354 | T026 |
36,232,304 | differ acut kidney injuri pattern renal ischemia reperfus injuri extracorpor membran oxygen mice use extracorpor membran oxygen ecmo associ acut kidney injuri aki thorac organ transplant howev multipl factor contribut aki develop procedur renal ischemia reperfus injuri iri due hypo perfus kidney surgeri studi aim explor kidney injuri pattern mous model ecmo renal iri kidney cbl mice examin moder min sever min unilater transient renal pedicl clamp h veno venous ecmo renal injuri marker neutrophil infiltr tubular transport function pro inflammatori cytokin renal heme oxygenas ho express determin immunofluoresc qpcr procedur caus aki differ injuri pattern sever neutrophil infiltr kidney evid renal iri follow ecmo tubular transport function sever impair renal iri preserv ecmo group procedur caus upregul pro inflammatori cytokin renal tissu differ time kinet ecmo iri ho strong induc tubular cell indic contact hemolysi deriv protein iri ho express infiltr myeloid cell tubulo interstiti space conclus renal iri ecmo caus aki kidney damag renal iri pronounc includ sever neutrophil infiltr tubular transport impair enhanc ho express tubular cell ecmo encourag limit hemolysi therapeut approach reduc ecmo associ aki | D058186;D015199;D015427 | T061;T047;T037 |
36,232,303 | allyl butyl phenylethyl isothiocyan modul akt mtor cyclin cdk signal gemcitabin cisplatin resist bladder cancer cell line combin cisplatin gemcitabin treatment caus rapid resist develop patient advanc urotheli carcinoma present studi investig potenti natur isothiocyan itc allyl isothiocyan aitc butyl isothiocyan bitc phenylethyl isothiocyan peitc suppress growth prolifer gemcitabin cisplatin resist bladder cancer cell line sensit gemcitabin cisplatin resist rt tccsup cell treat itc tumor cell growth prolifer clone format evalu apoptosi induct cell cycl progress investig well molecular mode action investig evalu cell cycl regul protein cyclin depend kinas cdks cyclin b mechanist target rapamycin mtor akt signal pathway itc signific inhibit growth prolifer clone format tumor cell line sensit resist cell arrest gm phase independ type resist alter cdk cyclin axi akt mtor signal pathway observ aitc treat cell minor effect apoptosi induct contrast aitc de activ akt mtor signal induc apoptosi rt cell minor effect cdk express conclud aitc bitc peitc exert tumor suppress properti cisplatin gemcitabin resist bladder cancer cell wherebi molecular action may differ among cell line integr itc gemcitabin cisplatin base treatment regimen might optim bladder cancer therapi | D002295;D001749 | T191 |
36,232,302 | mrna captur sequenc rt qpcr detect pathognomon novel secondari fusion transcript ffpe tissu sarcoma showcas assess perform mrna captur sequenc identifi fusion transcript ffpe tissu differ sarcoma type follow rt qpcr confirm valid workflow six posit control tumor specif chromosom rearrang analyz use trusight rna pan cancer panel fusion transcript call fusioncatch confirm aberr enabl identif fusion gene partner breakpoint next whole transcriptom truseq rna exom sequenc appli fusion gene negat alveolar rhabdomyosarcoma arm undifferenti round cell sarcoma urc tumor fluoresc situ hybrid fish identifi classic pathognomon rearrang six patient pathognomon fusion transcript readili detect ie pax foxo two arm patient ewsr fli ewsr erg ewsr nfatc four urc patient remain patient newli identifi fusion transcript confirm rt qpcr includ cop toml ncoa dtnb wwtr linc plaa mobb apb chek brd leutx fusion transcript arm patient addit recurr detect secondari fusion transcript patient diagnos ewsr nfatc posit sarcoma confirm cop tbcd picalm sytl smg vps ubef al conclus studi show mrna captur sequenc enhanc detect rate pathognomon fusion enabl identif novel secondari fusion transcript sarcoma | D012509;D012983 | T191 |
36,232,301 | genet obes human clinic review obes complex multifactori disord genet environment factor increas worldwid preval obes develop develop countri develop genom wide associ studi gwas next generat sequenc ngs increas discoveri genet associ awar monogen polygen caus obes genet obes could classifi syndrom non syndrom obes prader willi fragil x bardet biedl cohen albright hereditari osteodystrophi aho syndrom exampl syndrom obes associ development delay earli onset obes non syndrom obes could monogen polygen chromosom origin monogen obes caus variant singl gene polygen obes includ sever gene involv member gene famili new advanc genet test led identif obes relat gene leptin lep leptin receptor lepr proopiomelanocortin pomc prohormon convertas pcsk melanocortin receptor mcr singl mind homolog sim brain deriv neurotroph factor bdnf neurotroph tyrosin kinas receptor type gene ntrk report causat gene obes ngs use emerg use tool search candid gene obes clinic set | D044105;D054411 | T116;T192 |
36,232,300 | introduct guest editor special issu multi metal system strong cooper bond weak interact known chemic element call metal make major chemic element includ period tabl | D008670 | T197 |
36,232,299 | patholog featur paediatr patient tk defici thymidin kinas tk defici caus mitochondri dna deplet syndrom aim report clinic biochem genet histopatholog ultrastructur featur cohort paediatr patient tk defici mitochondri dna isol muscl biopsi assess deplet delet tk gene sequenc use sanger sequenc genom dna muscl biopsi present rag red fibr rrfs preval greater younger age along increas succin dehydrogenas sdh activ cytochrom c oxidas cox negat fibr endomysi inflammatori infiltr observ younger patient accompani overexpress major histocompat complex type mhc immunofluoresc studi complex iv show greater number fibr visual cox stain ultrastructur analysi found three major type mitochondri alter consist concentr arrang lamellar crista electrodens granul intramitochondri vacuol patholog featur muscl show substanti differ youngest patient compar later onset diseas addit ultrastructur featur describ muscl biopsi sarcomer de structur youngest patient sever phenotyp | D017240 | T047 |
36,232,298 | biolog activ diterpenoid clerodendrum genus review one key area interest pharmacognosi diterpenoid mani studi perform identifi new sourc optim isol biolog properti import sourc abietan pimaran clerodan type diterpenoid deriv member genus clerodendrum lamiacea due divers chemic natur type plant materi rang extract techniqu need various temperatur solvent type extract time well use ultrasound bath diterpenoid isol clerodendrum demonstr rang cytotox anti prolif antibacteri anti parasit anti inflammatori activ review describ various biolog activ diterpenoid isol far speci clerodendrum indic activ one well plant sourc take account structur term activ summaris method extract | D032409;D045785 | T109;T123;T002 |
36,232,297 | translat micrograv research earth applic topic translat micrograv research earth applic compris public focus space life scienc gravit biolog space medicin | D000337;D013026;D014893 | T091;T057;T070 |
36,232,296 | non isocyan aliphat aromat poli carbon urethan insight transurethan reaction structur properti relationship studi reveal insight transurethan reaction lead aliphat aromat non isocyan poli carbon urethan nipcus structur properti relationship crucial impact alkyl chain length diphenylmethylen bis hydroxyalkyl carbam bhac process transurethan reaction prove strong suscept hydroxyethyl hydroxybutyl carbam moieti back bite side reaction observ due format thermodynam stabl cyclic product urea bond bhac nipcus longer alkyl chain hydroxypentyl hydroxyhexyl hydroxydecyl carbam introduc bhac structur prone back bite side reaction h c nmr well ft ir spectroscopi confirm presenc carbon urethan urea sampl bond nipcus well prove lack allophan ether group increas alkyl chain length carbon atom urethan group nipcu hard segment result increas elong break crystallin phase content well decreas tg tensil strength hard moreov obtain nipcus exhibit except mechan properti eg tensil strength mpa elong break | D004986;D011140 | T121;T109;T122 |
36,232,295 | vaccin induc subcutan granuloma goat reflect differ host mycobacterium interact bcg recombin bcg deriv vaccin tubercul granuloma high dynam structur reflect complex host mycobacterium interact object studi compar granuloma develop site vaccin bcg recombin deriv goat character host respons epithelioid cell multinucl giant cell mngc cell subset b cell plasma cell dendrit cell mycobacteri antigen label immunohistochemistri lipid acid fast bacteria afb label specif stain granuloma central caseous necrosi develop inject site goat though lesion size extent necrosi differ vaccin strain cd b cell scarc cd cell numer granuloma induc recombin deriv compar parent bcg strain number mngcs cell lipid bodi mark lower group administ recombin bcg strain microscop detect afb mycobacteri antigen rather frequent area central necrosi howev isol bacteria cultur rare success summari bcg recombin deriv induc reproduc subcutan caseous granuloma goat easili monitor surgic remov studi granuloma reflect genet modif recombin bcg deriv therefor suitabl model compar reaction differ mycobacteria tb vaccin | D001500;D009161;D014376 | T047;T116;T007;T121;T129 |
36,232,294 | track topolog electron effect fold stabil guanin defici rna g quadruplex engin new comput tool de novo quadruplex fold initi aim work elucid mutual influenc differ singl strand segment loop cap thermodynam stabil rna g quadruplex end use new nab gq builder softwar program construct dozen two tetrad g quadruplex topolog base design librari sequenc probe sequenc morpholog stabil relationship design topolog perform molecular dynam simul result provid guidanc design g quadruplex balanc structur turn programm physicochem properti applic biomateri moreov compar examin singl strand segment three oncogen promot g quadruplex assess druggabl potenti futur therapeut strategi final basi thorough analysi quantum mechan level theori seri guanin assembl demonstr valenc tautomer trigger coordin cation initi process g quadruplex fold propos sequenti fold mechan otherwis dictat cancel dipol moment guanin | D054856 | T086 |
36,232,293 | antioxid activ quercetin h induc oxid stress model red blood cell function role band protein lifespan red blood cell rbcs expos larg number stressor therefor consid suitabl model investig cell respons oxid stress os studi conduct evalu potenti benefici effect natur antioxid quercetin q os model repres human rbcs treat h marker os includ hemolysi reactiv oxygen speci ros product thiobarbitur acid reactiv substanc tbar level oxid protein sulfhydryl group cd bp express methemoglobin format methb well anion exchang capabl band protein bp analyz rbcs treat h mm h without pre treatment h q rbcs pre treat mm h expos q result show pre treatment q effect post treatment counteract os rbcs particular pre exposur q avoid morpholog alter format acanthocyt prevent h induc os damag restor abnorm distribut bp cd express moreov h exposur associ decreas rate constant uptak via bp well increas methb format alter attenu pre treatment q result contribut elucid os relat event human rbcs propos q natur antioxid counteract os relat alter identifi bp possibl target treatment prevent os relat diseas condit age relat complic impact rbcs physiolog | D001457;D000975 | T116;T121;T123;T044;T039 |
36,232,292 | empagliflozin preserv skelet muscl function hfpef rat model besid structur alter myocardium heart failur preserv eject fraction hfpef also associ molecular physiolog alter peripher skelet muscl skm contribut exercis intoler often seen hfpef patient recent use sodium glucos transport inhibitor sglti clinic studi provid evid signific reduct combin risk cardiovascular death hospit hfpef present studi aim elucid impact empagliflozin empa skm function metabol mitochondri function establish hfpef rat model age week obes zsf rat random either receiv standard care empa drink water zsf lean anim serv healthi control week treatment echocardiographi skm contractil perform mitochondri function assess saponin skin fiber skm tissu snap frozen molecular analys hfpef evid obes anim compar lean increas e preserv left ventricular eject fraction empa treatment signific improv e result improv skm contractil reduc intramuscular lipid content better mitochondri function main complex iv minor modul atrophi relat protein seen empa treatment result clear document benefici effect empa skm function present hfpef model effect accompani posit effect mitochondri function possibl modul skm function | D060766;D006333;D012503 | T046;T047;T167;T109 |
36,232,291 | glycyrrhiz acid deriv promis candid manag type diabet mellitus complic type diabet mellitus tdm chronic metabol diseas character hyperglycemia chronic insulin resist progress declin cell function defect insulin secret becom one lead caus death worldwid present cure tdm treat blood glucos level control report diabet patient may suffer advers effect convent medicin therefor altern therapi tradit chines medicin tcm use manag treat diabet review glycyrrhiz acid gl deriv suggest promis candid treatment tdm complic princip bioactiv constitu licoric one type tcm review comprehens summar therapeut effect relat mechan gl deriv manag blood glucos level treat tdm complic addit also discuss exist clinic trial highlight research gap clinic research summari review provid understand gl deriv tdm well complic recent progress develop potenti drug target tdm | D003924;D007333 | T047;T046 |
36,232,290 | inhibit borrelia burgdorferi induc tlr nfb canon signal gallic acid target cd adaptor protein p molecul case lyme diseas caus borrelia burgdorferi infect increas throughout northern america europ pathogen treat time manner antibiot caus persist debilit health outcom search novel agent b burgdorferi investig phenol compound gallic acid anti borrelia anti inflammatori effect result show biocid effect start gml activ spirochet persistersround shape bodi biofilm like aggreg b burgdorferi sensu stricto activ macrophag live b burgdorferi also result robust nfb depend proinflammatori respons seen increas product cytokin use human cd macrophag vitro show cd adaptor phosphoryl p molecul imped nonbiocid noncytotox concentr gallic acid result inhibit express secret cytokin il il tnf find demonstr efficaci gallic acid b burgdorferi provid potenti mechanist insight tlrcd nfb mediat mode action studi potenti gallic acid safe effect compound borrelia caus infect warrant | D025065;D008193 | T007;T047 |
36,232,289 | impact spermidin cc myoblast prolifer redox status polyamin metabol h exposur central featur skelet muscl abil regener activ environment signal satellit cell activ cell prolifer myoblast defect process profound affect subsequ process regener high level reactiv oxygen speci hydrogen peroxid h consequ format oxid macromolecul increas myoblast cell death strong contribut loss myoblast function recent particular interest turn toward benefici effect muscl natur occur polyamin spermidin spd work test hypothesi spd upon oxid challeng would restor compromis myoblast viabil redox status effect spd combin aminoguanidin spd ag inhibitor bovin serum amin oxidas murin cc myoblast treat mild dose h evalu analyz myoblast viabil recoveri wound scratch ii redox status iii polyamin pas metabol treatment cc myoblast spd ag increas cell number acceler scratch wound closur h exposur caus redox status imbal cell death combin treatment spd ag show antioxid effect cc myoblast partial restor cellular total antioxid capac reduc oxid glutathion gshgssg ratio increas cell viabil reduct cell death moreov spd ag administr counteract induct polyamin catabol gene pa content decreas due h challeng conclus data suggest spd treatment protect role skelet muscl cell restor redox balanc promot recoveri wound scratch thus make myoblast abl better cope oxid insult | D006861;D013095 | T121;T109;T123;T130;T197 |
36,232,288 | molecular insight mrna polyadenyl deadenyl poli tail present almost eukaryot mrnas play critic role mrna stabil nuclear export translat effici biosynthesi shorten poli tail regul larg multiprotein complex howev molecular mechan protein machineri still remain unclear recent studi regard structur biochem characterist protein complex shed light potenti mechan polyadenyl deadenyl review summar recent structur studi pre mrna end process complex initi polyadenyl discuss similar differ yeast human machineri specif highlight recent biochem effort reconstitut activ human canon pre mrna end process system well role rbbpmpe activ entir machineri also describ poli tail remov pan pan ccr deadenyl complex discuss emerg role cytoplasm poli bind protein pabpc promot deadenyl togeth recent discoveri show dynam featur machineri play import role regul polyadenyl deadenyl | D026723;D029701 | T044;T116 |
36,232,285 | predict clean movement techniqu crossfit athlet use optim upper limb rang motion prospect cohort studi aim studi determin optim upper limb rang motion rom profil catch phase clean movement cpcm identifi key rom perform cpcm crossfit athlet | D012785;D034941 | T023;T030 |
36,232,284 | cocktail effect endocrin disrupt chemic applic chlorpyrifo lavend essenti oil chlorpyrifo pesticid toxic human health ban past decad due persist bioaccumul properti chlorpyrifo still present soil pregnant women expos chlorpyrifo drink water herbal product essenti oil eo result advers effect mother fetus object evalu compar potenti endocrin disrupt effect chlorpyrifo free contamin lavend eo studi releas four hormon activ px cell death receptor human placent jeg tox cell key biomark endocrin toxic pregnant women hplacentox assay observ free chlorpyrifo disrupt placent hormon activ px receptor wherea chlorpyrifo lavend eo disrupt placent hormon confirm chlorpyrifo classifi endocrin disrupt chemic edc pregnant women point endocrin disrupt effect may appar present lavend eo result reveal exist specif revers cocktail effect may protect properti edc | D004390;D060766;D052244;D027523;D009822;D010575 | T002;T167;T131;T109;T039 |
36,232,283 | feasibl biochar deriv sewag sludg promot sustain agricultur mitig ghg emiss review sewag sludg ss connect varieti global environment problem assess risk various dispos techniqu quit use recommend appropri manag prepar sewag sludg biochar ssb impact soil characterist plant health nutrient leach greenhous gas emiss ghgs critic review studi compar featur ssb obtain various pyrolysi temperatur reveal chang element content lower hydrogencarbon ratio ssb generat higher pyrolysi temperatur point exist aromat carbon molecul addit prepar ssb increas ash content lower yield higher surfac area result rise pyrolysi temperatur worldwid potenti ss output co equival emiss predict factor global popul common dispos manag order creat futurist strategi cope quantiti abund global ss accord estim worldwid ss output associ co eq emiss around million ton dri solid mt ds teragram tg respect quantiti rise mt ds sewag sludg tg co eq emiss increas regard develop popul countri may support econom growth util low cost method produc biochar employ local agricultur complet comprehend benefit drawback ssb soil supplement studi long term field applic ssb requir | D000074382;D012722 | T069;T197 |
36,232,282 | impact non face face teach passiv train person protect equip use health scienc student random control trial covid era call transform higher educ univers combin non face face teach tradit procedur studi analyz effect perceiv satisfact cohort health scienc student non face face teach passiv train versus face face teach activ train proper don dof person protect equip ppe clinic simul scenario | D000086382;D000067393 | T047;T073;T067 |
36,232,281 | forc transform regul captur research interact mechan environment regul green transform dairi farm subject product situat increas resourc environ shortag green transform dairi farm subject product driven environment regul concentr embodi promis govern solv problem breed environment pollut due shortcom environment regul undefin connot green transform dairi farm subject product interact relationship two remain unclear present base defin concept green transform dairi farm subject product paper aim analyz interact mechan environment regul green transform dairi farm main product build dynam game model environment regul dairi farm subject introduc constraint benefit reput mechan behavior model explor whether environment regul drive green transform dairi farm subject product result show green transform dairi farm subject product follow subject substitut view emphas sourc reduct process control termin treatment strict design environment regul could effect drive green transform dairi farm subject product inevit environment regul vulner rent seek behavior dairi farm subject regul captur introduct reput mechan great improv rent seek behavior dairi farm subject probabl environment regul regul captur indirect forc dairi farm subject particip green transform product greater punish dairi farm subject particip green transform product forc particip green transform product time also reduc risk damag credibl govern base studi paper also discuss shortcom environment regul includ exit light implement environment regul polici decentr light inspect environment regul subject result light process environment regul mode formal regul light inform regul environment regul form provid scientif refer formul environment regul polici livestock poultri breed futur compar previous studi paper innov two aspect first defin conceptu connot green transform dairi farm subject product second systemat discuss interact mechan environment regul green transform dairi farm subject product paper provid scientif refer develop futur environment regul polici livestock poultri farm | D000383;D058751 | T090;T008 |
36,232,280 | inequ low air qualiti relat health impact among socioeconom group world work research aim assess percept air qualiti health symptom caus low urban air qualiti among vulner socio econom group world work bangkok thailand questionnair survey worker formal inform sector five district differ socio econom characterist level air pollut find show symmetri air qualiti monitor data health symptom differ socio econom group asymmetri air qualiti monitor data peopl percept air qualiti area also show inequ low air qualiti relat health impact socio econom group world work peopl work near street highway industri zone tend health symptom relat low air qualiti inform sector worker face health risk formal sector worker studi appeal effect air pollut communic enhanc public inform sector worker popul literaci air pollut sourc air pollut critic health impact avail suffici primari care organ communiti health care center address work relat health need reach inform sector worker popul | D000397 | T069;T080 |
36,232,279 | associ primari care util emerg room hospit inpati servic util among middl age elder self referr system evid china health retir longitudin studi rapid econom growth age hospit inpati emerg servic util grown rapid emphas urgent requir adjust optim structur health servic util studi shown primari care effect way reduc inpati emerg room er servic util studi aim examin whether middl age elder individu select primari care outpati servic last month less er hospit inpati servic util select hospit outpati servic via self referr system data obtain four wave nation repres china health retir longitudin studi charl pool respond outpati visit age year use logist regress explor associ type outpati er visit hospit use zero truncat negat binomi regress examin impact outpati visit type number hospit length hospit day trend test use explor trend outpati visit type er hospit inpati servic util increas outpati visit among respond charl primari care outpati visit less like er visit adjust ci hospit adjust ci fewer hospit day adjust irr ci trend test show increas number total outpati visit associ lower hospit p higher odd er visit p find suggest polici maker need adopt systemat polici focus restructur balanc structur resourc servic util three tier healthcar system | D000078336;D007297 | T101;T081 |
36,232,278 | quantif influenc citratef ii molar ratio hydroxyl radic product pollut degrad fe ii catalyz h oxid process ligand enhanc hydroxyl radic oh product import strategi fe ii catalyz h oxid process howev influenc molar ratio ligand fe ii oh product remain elus studi employ citrat inorgan dissolv fe ii fe ii dis repres ligand fe ii speci respect quantifi relationship result show oh product high depend citratef ii molar ratio instanc oxygen fe ii dis oh accumul low moder high citratef ii molar ratio respect low citratef ii molar ratio lt inorgan fe ii dis main contribut oh product increas citratef ii molar ratio high level fe ii citrat complex turn electron sourc oh product chang fe ii speciat increas citratef ii molar ratio elev oh product pollut degrad mgl phenol degrad within min oxygen fe ii citrat system ph result suggest moder molar ratio ligandf ii may optim fe ii catalyz h oxid process | D004785;D017665 | T131;T197 |
36,232,277 | subject exercis experi group cohes among chines particip squar danc moder mediat model year particip gender background studi aim explor relationship year particip subject exercis experi group cohes among gender specif squar danc practition method subject exercis experi questionnair seeq group environ questionnair geq use evalu subject exercis experi see group cohes gc analysi conduct chines male femal use multipl group analysi within structur equat model result posit aspect subject exercis experi see posit well pwb strong posit effect gc group negat aspect see psycholog fatigu pf psycholog distress pd negat effect gc b male group indirect effect particip year associ see gc model b ci standard error se p c signific differ path coeffici notic associ year particip see gc conclus base result gender differ term partial mediat role adher relationship see gc present futur research fit popular societi | D003615;D000079225 | T056;T048 |
36,232,276 | type communiti support servic self efficaci continu communiti live among individu disabl caregiv studi explor impact five type communiti support servic ie center base care home base care respit care caregiv assist financi subsidi self efficaci continu communiti live among individu disabl caregiv | D017028;D006233 | T098;T101;T097;T099 |
36,232,275 | loneli intim relationship scale lir develop valid intim relationship shown loneli posit relat self esteem happi well also regard buffer loneli nevertheless substant research indic intim relationship marriag produc result loneli thus serious affect person physic emot spiritu well loneli intim relationship may damag relationship goe thus newli develop scale introduc aid clinician research discov loneli intim union address negat affect union sinc none measur loneli tap loneli experienc intim relationship new rate scale loneli intim relationship scale lir develop test psychometr generat item follow qualit approach base semi structur questionnair administ volunt general isra popul theoret empir literatur assess expert psychologist second studi n self report scale assess loneli intim relationship develop follow psychometr construct valid evalu new sampl particip analys reveal loneli intim relationship experienc main term three aspect detach hurt guilt exploratori confirmatori factor analys valid test indic final item loneli intim relationship scale well structur reliabl valid scale tap emot behavior cognit manifest loneli intim relationship | D008132 | T033 |
36,232,274 | relationship frequenc breakfast consumpt convers parent somat symptom children three wave latent growth model breakfast consumpt essenti children generat energi day parent play import role children breakfast habit spend time parent breakfast great influenc children emot develop therefor studi investig relationship frequenc children breakfast consumpt time spent convers parent children somat symptom data obtain korea children youth panel survey initi collect fourth grade elementari school student follow three year spss amo softwar use data analysi multivari latent growth model appli analyz effect breakfast consumpt frequenc children somat symptom mediat effect parent child convers time relationship consequ children frequenc breakfast consumpt increas somat symptom decreas furthermor parent child convers time mediat relationship two variabl therefor student parent teacher educ import breakfast communic parent student emot health | D062408;D000071896 | T056;T184 |
36,232,273 | impact transport restructur intens greenhous gas emiss empir data china adjust transport structur reduc intens greenhous gas emiss effect way address climat chang issu paper select six transport sector construct hybrid input output model studi impact transport restructur intens co non co greenhous gas emiss sector differ period result show effect transport restructur greenhous gas emiss manifest differ differ time period transport restructur signific effect reduc intens greenhous gas emiss sector howev impact transport restructur intens non co greenhous gas emiss limit also found railway transport sector low impact transport sector term greenhous gas emiss sinc provid insight optim china transport structur | D000074382 | T197 |
36,232,272 | effect receiv financi support adult children depress among older person mediat role social particip older person vulner depress sfdure age process financi resourc social particip expect impact depress symptom studi investig relationship financi support children depress among chines older person well mediat effect social particip relationship data particip age extract wave china health retir longitudin survey charl multivari regress analysi perform cross section data two wave longitudin data test hypothes result reveal financi support children negat associ depress symptom short term long term addit relationship partial mediat social particip short term associ fulli mediat social particip long term financi support posit relat social particip social particip negat associ depress symptom studi offer depth insight relationship financi support children depress among chines older person polici initi stimul social particip promot improv older person mental health | D032721;D058992 | T054;T099 |
36,232,271 | factor associ accept mass drug administr filariasi systemat review mass drug administr mda implement tool elimin lymphat filariasi accept among suscept popul crucial achiev mda effect coverag systemat review aim present systemat determin factor associ accept mda articl relat factor associ accept collect electron three differ databas scopus web scienc pubm four pair independ review screen titl abstract collect data store endnotex inclus criteria afterward includ articl critic apprais assess qualiti studi use mix method apprais tool mmat articl identifi includ final review knowledg awar attitud percept communic deliveri access mda gender age factor associ mda accept communiti accept remain challeng implement mda expand mda coverag endem countri strong need address factor influenc communiti accept mda | D004605;D005369 | T121;T047 |
36,232,270 | evalu method water resourc suitabl territori spatial plan case studi baiyin citi semi arid region water resourc major factor spatial layout agricultur product urban construct import part china ongo territori spatial plan order assess constrain guid effect water resourc territori spatial plan water resourc suitabl evalu need carri grid scale tradit basin region scale indic water resourc satisfi requir high spatial accuraci territori spatial plan intern differ could describ studi irrig water suppli cost index cia urban water suppli cost index ciu evalu character afford potenti water suppli cost simul optim water suppli path grid scale index water resourc suitabl agricultur product wrsa urban construct wrsu construct grade wrsa wrsu classifi grid scale baiyin citi area water resourc suitabl relat suitabl less suitabl unsuit agricultur product km km km km respect account total area baiyin citi area water resourc suitabl relat suitabl less suitabl unsuit urban construct km km km km respect account total area baiyin citi coupl analysi land use land resourc suitabl carri studi show grid scale wrsa wrsu could well character spatial differ water resourc suitabl agricultur product urban construct result geodetector base studi show wrsa wrsu indic better explanatori power land use spatial distribut compar indic water distanc therefor index could provid scientif support delimit agricultur space urban space effect mean determin region function water resourc territori spatial plan furthermor index could appli arid semi arid area also hilli area water suppli suitabl play restrict role agricultur product urban construct | D003247;D062066 | T064;T081;T069;T078;T070 |
36,232,269 | physic activ execut function adolesc mediat role sleepi background physic activ sleepi found influenc develop execut function present studi aim address effect differ level physic activ adolesc execut perform ie work memori inhibit role sleepi relationship hypothes higher level physic activ would associ better execut function relationship mediat least partial reduc sleepi school method adolesc age recruit request wear acceleromet seven consecut day measur daili level physic activ cleveland adolesc sleepi questionnair casq use assess sleepi work memori inhibit control assess indic execut function result found sedentari activ negat associ work memori perform light moder vigor physic activ relat better work memori relationship differ level physic activ work memori mediat reduc sleepi school conclus find provid nuanc evid benefit light moder vigor physic activ cognit develop could explain reduc sleepi school | D056344;D000077260 | T041;T048 |
36,232,268 | econom burden associ depress symptom among middl age elder peopl chronic diseas china coexist physic diseas depress symptom exacerb morbid disabl increment econom burden remain unclear use cross section data china health retir longitudin studi charl survey estim econom burden associ depress symptom among middl age elder peopl chronic diseas multivari regress model use assess annual health care util expenditur product loss depress symptom among peopl common chronic diseas found depress symptom associ higher increment econom burden total health care cost increas annual product loss increas cancer malign tumor largest econom burden associ depress symptom cni addit annual health care cost loss cni due addit annual product loss effect depress symptom econom burden patient chronic condit increas number chronic condit consid high econom burden associ depress symptom among patient chronic condit import consid mental health patient chronic diseas treatment manag | D003863;D000086522 | T033;T184;T048;T041 |
36,232,267 | caus stress among healthcar profession success hospit manag approach mitig covid pandem cross section studi outbreak covid pandem pose immedi challeng manag hospit germani elsewher risk stress front line healthcar profession forc occup health safeti unit adopt varieti protect measur thorough valid main object present analysi assess import sourc stress protect measur appli counteract stress among healthcar staff greatest impact better understand factor improv hospit manag worker safeti futur health crisi situat may also prove benefici non crisi situat purpos exploratori cross section quantit studi use questionnair creat purpos carri total profession nurs physician klinikum mittelbaden balg hospit baden baden germani first wave pandem statist analys show nurs suffer stress physician stress higher among profession critic care emerg unit unit less expos infect patient also found measur salari incent encourag work well integr team perceiv support hospit manag mitig stress find highlight import support measur manag superior know actual effect measur appli manag factor mention could help protect healthcar profession event anoth pandem similar situat may still valu deal continu covid pandem | D000086382 | T047;T067 |
36,232,266 | factor influenc concentr traffic urban environ case studi guangzhou citi ozon pollut serious issu china pose signific threat peopl health traffic emiss main pollut sourc urban area x volatil organ compound voc traffic emiss main precursor thus crucial investig relationship traffic condit pollut studi focus potenti relationship concentr traffic condit roadsid urban background guangzhou one largest citi china result demonstr signific differ concentr observ roadsid urban background environ howev concentr time higher sunni day gm cloudi day due meteorolog condit result confirm limit traffic emiss may increas concentr guangzhou therefor focus industri energi transport emiss mitig influenc meteorolog condit minim pollut result studi provid theoret basi mitig emiss polici china | D000393;D000397;D010126;D055549 | T131;T069;T109;T103;T080 |
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