PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,467 | util physiolog activ molecular compon grape seed grape marc nutrit intervent may high contribut mainten restor human health grape viti vinifera one oldest known benefici nutrit compon human diet high polyphenol content proven enhanc human health beyond doubt statist base public health studi especi prevent cardiovascular diseas cancer current review concentr present classifi polyphenol bioactiv molecul resveratrol quercetin catechinepicatechin etc avail high quantiti viti vinifera grape byproduct molecular pathway cellular signal cascad involv effect polyphenol molecul also present review summar current avail vitro vivo experiment literatur data biolog activ most easili access tabular form new molecul differ therapeut purpos also synthes base exist polyphenol compound class avail high quantiti grape wine grape marc therefor overview molecular structur provid novel possibl dendrim nanobioconjug review current avail vitro vivo experiment literatur data polyphenol biolog activ present easili access tabular form scope review detail antidiabet anticarcinogen antivir vasoprotect neuroprotect role grape origin flavonoid novelti studi lie descript process agricultur product grape seed skin industri relev detail descript molecular mechan action addit review clinic therapeut applic polyphenol uniqu summari studi yet done | D002392;D050091;D027843 | T116;T002;T122;T121;T109;T168;T129;T104 |
36,232,466 | zinc finger homeobox famili cancer doubl edg sword zinc finger homeobox zhx famili includ zhx zhx zhx protein similar uniqu structur contain two ch type zinc finger motif four five hox like homeodomain member zhx famili form homodim heterodim subunit nuclear factor previous studi suggest zhxs function posit negat transcript regul recent studi reveal biolog function under mechan cancer review summar advanc zhx mediat function includ tumor suppress oncogen function cancer format progress molecular mechan regulatori function cancer cell prolifer migrat invas metastasi moreov differenti express level associ good poor outcom patient various malign differenti respons chemotherapi exert opposit function oncogen tumor suppressor therefor zhxs act doubl edg sword cancer | D005801;D009369 | T191;T028 |
36,232,465 | drb modul leaf roll regul accumul microrna relat leaf develop rice import agronom trait rice oryza sativa moder leaf roll help maintain erect leav minim shadow leav lead improv photosynthet effici grain yield howev molecular mechan under rice leaf roll still need elucid isol rice mutant rl show adaxi roll leaf phenotyp due decreas number size bulliform cell confirm rl phenotyp caus singl nucleotid substitut osdrb locosg gene encod doubl strand rna bind gene constitut express encod protein local nucleus cytoplasm yeast two hybrid assay show osdrb could interact dicer like dcl osdrb respect qrt pcr analysi relat gene suggest defect osdrb mir oshb pathway could play import role format roll leaf phenotyp rl osdrb mutat reduc mir accumul result elev express class iii homeodomain leucin zipper gene oshb involv leaf polar andor morpholog develop moreov osdrb mutat also reduc accumul mir mir mir mir could caus abnorm leaf develop rl regul express target gene relat leaf develop | D035683;D012275 | T002;T123;T168;T114 |
36,232,464 | lactobacillus rhamnosus cy enhanc intestin barrier function regul tight junction protein express oxid stress inflamm respons lipopolysaccharid induc caco cell intestin barrier vital prevent inflammatori bowel diseas ibd object studi assess whether lactobacillus rhamnosus cy could allevi oxid stress inflamm disrupt tight junction tj barrier function induc lipopolysaccharid lps therefor explor potenti under molecular mechan result show lps induc cancer coli caco cell signific increas level reactiv oxygen speci ros lactat dehydrogenas inflammatori cytokin interleukin interleukin interleukin tumor necrosi factor il il il tnf cell apoptosi rate decreas level tj protein occludin zonula occluden zo claudin antioxid enzym catalas superoxid dismutas glutathion peroxidas cat sod gsh px p lt howev lactobacillus rhamnosus cy could reliev cytotox apoptosi oxid stress pro inflammatori cytokin express also inhibit toll like receptor nuclear factor kappa b tlrnf b signal pathway furthermor gene express antioxid enzym well mrna protein express tj protein improv particular concentr cfuml signific prevent inflammatori injuri induc lps caco cell p lt find support potenti applic lactobacillus rhamnosus cy probiot prevent lps induc intestin injuri treat intestin barrier dysfunct | D052201;D062725 | T007;T123;T116 |
36,232,463 | formul characteris evalu antihypertens peptid isoleucin prolin prolin leucin lysin prolin chitosan nanoparticl coat zein oral drug deliveri isoleucin prolin prolin ipp leucin lysin prolin lkp food deriv tripeptid whose antihypertens function demonstr hypertens rat model howev peptid display low oral bioavail due poor intestin epitheli permeabl instabl ipp lkp formul nanoparticl np use chitosan cl via ionotrop gelat coat zein follow addit zein high encapsul effici ee gt obtain np simul gastric fluid sgf cumul releas peptid achiev h wherea simul intestin fluid sif cumul releas observ h higher colloid stabil mv observ coat np compar uncoat one mv vitro cytotox studi show reduct cellular viabil human intestin epitheli caco hepg liver cell upon exposur np np compon administr np encapsul ipp lkp oral gavag spontan hypertens rat shr attenu systol blood pressur sbp h suggest np provid appropri releas achiev prolong hypotens effect vivo conclus chitosan zein nanoparticl cz np potenti oral deliveri system encapsul ipp lkp | D048271;D053758;D015028 | T116;T073;T121;T109;T123 |
36,232,462 | temperatur bias mirna express pattern european sea bass dicentrarchus labrax develop environment effect particular temperatur chang demonstr influenc activ function well teleost temperatur may chang season wild captiv aquacultur oper moreov climat chang expect shift temperatur profil worldwid microrna mirna import temperatur sensit gene express regul act post transcript level known key regul develop reproduct immun respons therefor earli larval develop european sea bass dicentrarchus labrax one extens cultur speci mediterranean aquacultur investig earli rear temperatur ie c regard impact temperatur mirna sncrna high throughput sequenc also phenotyp level term growth sex vision skelet deform express profil reveal stage temperatur specif mirna express target gene role reproduct immun respons main flexion fin stage similar stage temperatur specif result also observ concern number rod cell lower jaw elong present work present first time high promis result influenc earli rear temperatur post transcript level european sea bass develop putat impact reproduct immun respons well regard teleost vision larval develop | D001492;D035683;D058727 | T123;T013;T114 |
36,232,461 | probe potenti mechan quercetin kaempferol heat stress induc sertoli cell injuri integr network pharmacolog experiment valid quercetin kaempferol flavonoid wide present fruit veget medicin plant attract much attent due antioxid anti inflammatori anticanc antibacteri neuroprotect properti guarante cell direct contact germ cell sertoli cell exert role support nutrit protect spermatogenesi current studi network pharmacolog use explor target signal pathway quercetin kaempferol treat spermatogen disord vitro experi integr verifi result quercetin kaempferol heat stress induc sertoli cell injuri onlin platform use analyz go biolog pathway kegg pathway result network pharmacolog show quercetin kaempferol intervent spermatogenesi disord most target oxid respons oxid stress ros metabol process nfb pathway result cell experi show quercetin kaempferol prevent declin cell viabil induc heat stress reduc express level hsp ros sertoli cell reduc p nf b p p ib level regul express occludin vimentin f actin sertoli cell protect cell structur research first demonstr quercetin kaempferol may exert effect resist injuri cell viabil structur heat stress | D002056;D011794 | T121;T109;T127;T037 |
36,232,460 | dendrim tetraphenylmethan moieti central core synthesi pore studi adsorpt volatil organ compound reason yield two dendrim central tetraphenylmethan peripher di tert butanoylamino benzoylpiperazin moieti prepar dendrim void space solid state adsorb guest molecul bet valu vari depend h bond interact peripher moieti gas molecul dendrit framework fabric void space flexibl presenc polar gas molecul co bet increas signific time bet n one dendrim adsorb cyanobenzen level mgg author best knowledg almost equival highest report valu literatur | D050091;D055549 | T104;T109;T122 |
36,232,459 | prepar character degrad cellulos base paper superhydrophob antibacteri barrier properti food packag great paradigm foremost food packag use renew biodegrad lignocellulos base materi instead plastic novel packag success prepar cellulos paper coat mixtur polylact acid pla cinnamaldehyd cin barrier screen nano silica modifi stearic acid sasio superhydrophob layer comprehens investig various test result show prepar packag possess excel thermal stabil attribut inorgan sio incorpor excel film form characterist pla improv tensil strength manufactur paper mpa compar origin cellulos paper mpa enhanc benefit rough nanostructur surfac modifi low surfac energi sa contact angl composit paper attain own superhydrophob perform various liquid moreov composit paper show excel gas moistur oil bacteria barrier properti result reinforc function coat cobb wvp composit paper reduc respect antibacteri effici novel composit paper remark thermal stabil tensil strength barrier properti exploit potenti candid eco friend renew biodegrad cellulos paper base composit substitut petroleum deriv packag | D018857;D010578 | T109;T073 |
36,232,458 | lipophil compound antibacteri activ opuntia ficus indica root extract algeria chemic composit investig gas chromatographi mass spectrometri antibacteri activ lipophil extract three varieti opuntia ficus indica root algeria report paper first time result obtain reveal total compound includ fatti acid sterol monoglycerid long chain aliphat alcohol identifi quantifi sitosterol found major compound root three varieti furthermor consider amount essenti fatti acid oleic linol linolen acid also identifi green varieti richest among three studi varieti antibacteri activ evalu disc diffus method reveal lipophil extract effect main gram posit staphylococcus aureus methicillin resist staphylococcus aureus mrsa mm gram negat strain main pseudomona aeruginosa gave inhibit zone mm consid high antibacteri activ minim inhibitori concentr test bacteria reveal interest valu major bacteria test g ml bacillus sp gml two staphylococcus strain g ml e coli g ml obtain pseudomona sp studi allow us conclud lipophil fraction cactus root possess interest phytochem steroid fatti acid long chain alcohol act antibiot like compound counter pathogen strain | D055624;D029747;D010840 | T002;T007;T121;T109;T123 |
36,232,457 | respons rice overlap growth stage water stress assimil accumul transport starch synthesi superior inferior grain drought stress joint boot direct affect plant growth product rice limit natur factor joint boot stage short growth period rice varieti high overlap high latitud area sensit water deficit howev littl known dri matter transloc rice strategi starch synthesi fill superior inferior grain differ drought stress unclear studi rice plant subject three degre drought stress kpa kpa kpa day joint boot stage investig dri matter accumul transloc grain fill enzym activ starch synthesi superior inferior grain rice overlap growth stage result show drought stress signific reduc dri matter accumul stem leav mild moder drought increas dri matter transloc effici howev sever drought stress larg limit dri matter accumul transloc larg amount dri matter remain veget organ sever drought stress high content nsc stem sheath play key role resist drought stress drought stress joint boot direct caus chang grain fill strategi moder sever drought grain fill activ period superior grain shorten complet necessari reproduct growth grain fill activ period inferior grain signific prolong avoid decreas grain yield signific decreas grain fill rate superior inferior grain caus reduct thousand grain weight particular influenc grain fill rate inferior grain thousand grain weight signific drought stress chang starch synthesi strategi superior inferior grain solubl starch synthas starch branch enzym activ inferior grain increas signific drought stress gbss activ sensit drought stress therefor amylos content decreas amylopectin synthesi enhanc drought stress especi inferior grain | D015061;D012275;D013214 | T002;T126;T116;T168 |
36,232,456 | heterozyg loss krit mice affect metabol function liver promot hepat oxid glycat stress krit loss function mutat underli pathogenesi cerebr cavern malform ccm major vascular diseas affect central nervous system cns howev krit also express outsid cns modul key regul metabol oxi inflammatori pathway includ master transcript factor foxo suggest widespread function signific herein show kritfoxo axi implic liver metabol function antioxidativeantiglyc defens inde perform compar studi krit heterozyg krit wild type mice found krit haploinsuffici result foxo expressionact downregul liver affect hepat foxo depend signal pathway marker major metabol process includ gluconeogenesi glycolysi mitochondri respir glycogen synthesi moreov caus sustain activ master antioxid transcript factor nrf hepat accumul advanc glycat end product age abnorm expressionact age receptor detoxifi system furthermor associ impair food intak system glucos dispos plasma level insulin specif molecular alter detect liver krit mice also confirm krit knockout cell overal find demonstr first time krit haploinsuffici affect glucos homeostasi liver metabol antioxidativeantiglyc function thus inspir futur basic translat studi | D061385;D051267 | T121;T123;T116 |
36,232,455 | applic artifici intellig climat resili smart crop breed recent artifici intellig ai emerg revolutionari field provid great opportun shape modern crop breed extens use indoor plant scienc advanc crop phenom envirom togeth omic approach pave way elucid detail complex biolog mechan motiv crop function respons environment trepid omic approach provid plant research precis tool evalu import agronom trait larger size germplasm reduc time interv earli growth stage howev big data complex relationship within imped understand complex mechan behind gene drive agronom trait format ai bring huge comput power mani new tool strategi futur breed present review encompass applic ai technolog util current breed practic assist solv problem high throughput phenotyp gene function analysi advanc ai technolog bring new opportun futur breed make envirotyp data wide util breed furthermor current breed method link genotyp phenotyp remain massiv challeng imped optim applic high throughput field phenotyp genom envirom review elabor ai prefer tool increas accuraci high throughput crop phenotyp genotyp envirotyp data moreov explor develop approach challeng multiom big comput data integr therefor integr ai omic tool allow rapid gene identif eventu acceler crop improv program | D018556;D000069600 | T040;T002 |
36,232,454 | dexamethason load hydrogel improv motor cognit function rat mild traumat brain injuri model function recoveri follow traumat brain injuri tbi limit due progress neuron damag result secondari injuri associ neuroinflamm steroid anti inflammatori drug dexamethason dx reduc neuroinflamm activ microglia infiltr macrophag previous work develop hydrolyt degrad poli ethylen glycol bis acryloyloxi acet peg bis aa hydrogel dexamethason dx conjug hyaluron acid ha dxm demonstr dexamethason load hydrogel peg bis aaha dxm reduc neuroinflamm apoptosi lesion volum improv neuron cell surviv motor function recoveri seven day post injuri dpi rat mild tbi model studi investig effect local applic peg bis aaha dxm hydrogel motor function recoveri dpi cognit function recoveri well secondari injuri dpi rat mild cci tbi model observ peg bis aaha dxm treat anim exhibit signific improv motor function rotarod test cognit function morri water maze test compar untreat tbi anim also observ peg bis aaha dxm hydrogel reduc inflammatori respons apoptosi lesion volum compar untreat anim dpi therefor peg bis aaha dxm hydrogel promis therapeut intervent tbi treatment | D001924;D000070642 | T037 |
36,232,453 | ablat presynapt protein mover impair learn perform decreas anxieti behavior mice presynapt protein movertprglsvap absent drosophila c elegan differenti express synaps rodent brain suggest confer specif function subtyp presynapt termin order investig absenc protein affect behavior learn mover knockout mice ko subject seri establish learn test determin possibl behavior cognit alter male femal week old ko cblj wildtyp wt control mice test batteri memori anxieti test test includ cross maze novel object recognit test morri water maze mwm elev plus maze epm open field test mover ko mice show impair recognit memori test decreas anxieti behavior epm mover ko lead chang work memori cross maze spatial refer memori mwm howev detail analysi swim strategi demonstr allocentr specif memori deficit male ko mice data indic mover appear control synapt properti associ specif form memori format behavior suggest modulatori role synapt transmiss | D001007;D017173 | T041;T184;T048;T204 |
36,232,452 | compar transcriptom analysi two peach rootstock uncov effect gene differenti express nitrogen use effici nitrogen import nutrient element limit plant growth yield format excess nitrogen negat effect plant environ import reveal molecular mechan high nue nitrogen use effici breed peach rootstock varieti high nue studi two peach rootstock shannong maotao differ nue use materi treat mm kno transcriptom sequenc togeth control group result comparison group found two rootstock differ respons kno kcls vs kclm kno vs kcls kno vs kno kno vs kclm differenti express gene deg identifi respect includ multipl transcript factor famili deg enrich mani biolog process signal transduct pathway includ nitrogen metabol plant hormon signal transduct function ppnrt show regul express kno treatment verifi heterolog express arabidopsi plant height spad soil plant analyz develop leaf primari root length transgen plant increas compar wt indic role ppnrt nitrogen metabol studi uncov first time differ molecular regulatori pathway involv nitrogen metabol two peach rootstock provid gene reserv studi molecular mechan nitrogen metabol theoret basi screen peach rootstock varieti high nue | D000068239;D059467 | T168;T081;T002;T086 |
36,232,451 | differenti respons ileal colon microbiota rat high fat diet induc atherosclerosi grow evid suggest gut microbiota associ atherosclerosi howev function heterogen gut segment give rise region differ gut microbiota establish rat model feed rat high fat diet long period patholog microbiota chang ileum colon rat examin correl microbiota analyz aortic mesothelium experiment rat damag intima show evid calcium salt deposit indic rat model success develop note vari degre patholog damag ileum colon experiment rat rdna high throughput sequenc show signific differ divers divers microbiota comparison ileum colon furthermor ileum colon rat show vari degre intestin microbiota disturb articl contribut studi relationship microbiota differ region gut provid new approach gut microbiota intervent treatment | D050197;D064307 | T047;T046;T028;T001;T032 |
36,232,450 | effect post harvest ozon treatment molecular stabil marker amelanchi alnifolia nutt fruit cold storag fruit amelanchi alnifolia nutt ex roem nutt good sourc bioactiv compound vitamin due fact berri soft fruit requir special procedur increas molecular mechan stabil cold storag studi investig effect ozon treatment appli cyclic everi h select chemic mechan paramet saskatoon berri kept storag purpos measur perform assess chang molecular marker antioxid potenti content vitamin c total polyphenol well microbi stress maximum destruct forc uniaxi compress sampl effect storag process also assess relat condit use determin proport fruit affect diseas occur storag find show ozon treatment led increas content bioactiv compound initi stage storag result decreas loss water bioactiv compound later stage ultim irrespect condit appli ozon treatment observ growth micro organ fruit surfac inhibit result storag loss relev period signific reduc | D010126;D027824 | T103;T002 |
36,232,449 | metagenom sequenc diagnosi plasmodium spp differ level parasitemia edta blood malaria patient proof principl assess molecular diagnost approach increas includ diagnost workup even primari diagnosi malaria non endem set difficult maintain skill microscop malaria detect due rariti diseas pathogen specif nucleic acid amplif howev bear risk overlook pathogen associ febril ill returne tropic assess discriminatori potenti metagenom sequenc identif differ plasmodium speci various parasitemia edta blood malaria patient overal proport plasmodium spp specif sequenc read assess sampl show robust posit correl parasitemia spearman r p robust negat correl cycl threshold ct valu genus specif real time pcr spearman r p depend appli bioinformat algorithm discrimin speci level success instanc limit factor discrimin speci level low parasitemia speci depend lack avail reliabl refer genom mix infect high varianc proport infect speci summari metagenom sequenc perform studi suitabl detect malaria human blood sampl diagnost detect limit reliabl discrimin speci level remain higher compet diagnost approach like microscopi pcr | D008288;D009696;D010961 | T047;T123;T204;T114 |
36,232,448 | associ mir health relat qualiti life cognit function clinic data patient differ grade glioma tumor glioma central nervous system tumor lethal prognosi small micro rna molecul particip various biolog process tissu specif therefor could promis target cancer treatment thus studi aim examin mir potent biomark diagnosi prognosi glioma patient first time find associ express level mir patient qualiti life qol cognit function express level mir analyz post oper ii iv grade glioma quantit real time polymeras chain reaction express profil compar patient clinic data age surviv time oper tumor grade locat mutat status isocitr dehydrogenas idh promot methyl methylguanin methyltransferas furthermor health relat qol assess use karnofski perform scale qualiti life questionnair cognit assess assess hopkin verbal learn test revis trail make test phonem fluenci task express mir signific lower tumor grade iii iv associ idh wild type glioma wors prognosi patient overal surviv addit posit correl observ mir level function status qol glioma patient therefor mir uniqu molecul play import role gliomagenesi also associ chang patient qualiti life | D001932;D005910;D035683 | T191;T123;T114 |
36,232,447 | waldenstrm macroglobulinemia mechan diseas progress current therapi waldenstrm macroglobulinemia indol b cell lymphoma without known cure bone marrow microenviron cytokin play key role waldenstrm macroglobulinemia wm tumor progress one fda approv drug exist treatment wm ibrutinib treatment plan involv varieti drug inhibitor review explor avenu tumor progress target drug therapi investig wm relat b cell lymphoma | D016393;D008258 | T191 |
36,232,446 | heterogen evolut sex chromosom torrent frog genus amolop sharp contrast bird mammal numer cold blood vertebr sex chromosom describ homomorph sex chromosom homomorphi suggest result high turnov often observ across deepli diverg clade howev littl known tempo mode sex chromosom evolut among close relat speci examin evolut sex chromosom among nine speci torrent frog genus amolop analyz male femal gbs rad seq individu perform pcr verif individu identifi signatur sex chromosom involv two pair chromosom found sex chromosom homomorphi result turnov x recombin amolop speci simultan exhibit heterogen evolut homolog non homolog sex chromosom low turnov rate non homolog sex chromosom exist torrent frog ongo x recombin homolog sex chromosom act indispens forc prevent sex chromosom differenti | D011995;D012730 | T026;T045 |
36,232,445 | full length transcriptom map reef build coral illumin molecular basi calcif symbiosi circadian gene coral transcriptom data larg reli short read sequenc sever limit understand coral molecular mechan leav mani import biolog question unresolv sequenc full length transcriptom four common frequent domin reef build coral use pacbio sequel ii platform obtain inform report gene function structur express profil among compar analysi biominer relat gene provid insight molecular basi coral skelet densiti gene express profil symbiont symbiodiniacea also isol annot holobiont sequenc data final phylogenet analysi key circadian clock gene among evolutionarili repres speci indic four key member earli metazoan includ cri gene clock npas cyc arntl tim per fifth member occur bilateria summari work provid foundat work manipul skeleton product symbiosi promot surviv import organ | D037421;D004141 | T204 |
36,232,444 | arabidopsi ubiquitin conjug enzym ubc ubc ubc major function sugar metabol leaf senesc ubiquitin conjug enzym e requir protein ubiquitin arabidopsi es group subfamili function mani unknown util genet biochem method studi role arabidopsi ubc ubc ubc e subfamili iv arabidopsi ubc tripl mutant plant higher level glucos sucros starch control plant well higher protein level key gluconeogen enzym cytosol fructos bisphosphatas cyfbp vitro assay proteasom inhibitor mg inhibit degrad recombin cyfbp wherea atp promot cyfbp degrad quadrupl mutant ubc cyfbp sugar level return normal suggest increas sugar level ubc mutant due increas cyfbpas level addit ubc mutant plant show earli leaf senesc late stage plant develop well acceler leaf senesc use detach leav leaf senesc phenotyp remain quadrupl ubc cyfbp mutant result suggest ubc two line import function sugar metabol regul cyfbp protein level leaf senesc like cyfbp independ mechan | D017360;D029701 | T116;T002 |
36,232,443 | vitro vivo valid gata suppress induct adipogenesi improv insulin sensit impair adipogenesi associ develop insulin resist increas risk type diabet td gata bind protein gata implic impair adipogenesi onset insulin resist therefor hypothes inhibit gata could promot adipogenesi restor healthi fat distribut enhanc insulin signal primari human preadipocyt treat gata inhibitor dnazym hgd cell prolifer adipogen capac gene express insulin signal measur follow well establish protocol balbc mice treat dnazym hgd period week liposom load dnazym hgd pioglitazon posit vehicl negat control administ subcutan everi day right thigh end studi adipos tissu collect weigh site inject opposit side oment depot antioxid enzym superoxid dismutas catalas activ assess anim sera gene express measur use well establish protocol vitro gata inhibit induc adipogenesi primari human preadipocyt enhanc insulin signal reduc express psk vivo gata inhibit promot adipogenesi site inject reduc mcp express gata inhibit also reduc oment tissu size ppar express find suggest modul gata express offer potenti therapeut benefit correct impair adipogenesi promot healthi fat distribut improv insulin sensit potenti lower risk td | D021881;D003924;D007333 | T047;T046;T116;T126;T114 |
36,232,442 | effect rage delet cardiac transcriptom age cardiac age character increas cardiomyocyt hypertrophi myocardi stiff fibrosi enhanc cardiovascular risk receptor advanc glycat end product rage involv sever age relat diseas rage knockout rage mice show acceler cardiac dimens chang interstiti fibrosi age studi identifi age associ cardiac gene express signatur induc rage delet analyz left ventricl transcriptom young middl age old month old femal rage cbln wt mice compar young old rage versus age match wt mice identifi differ express gene respect function infer analysi show rage delet associ regul gene involv antigen process present exogen antigen adapt immun respons cellular respons interferon beta gamma young anim ii regul gene relat fatti acid oxid cardiac structur remodel cellular respons hypoxia mice iii regul gene belong complement activ triglycerid biosynthet process old anim find show age depend cardiac phenotyp rage mice associ alter gene relat adapt immun cardiac stress pathway | D000375;D059467 | T081;T040;T086;T033 |
36,232,441 | relat structur zn ii bind affin shed light mechan rad hook domain function phosphoryl metal bind protein protein interfac still unchart territori intermolecular interact date protein complex bind zn ii intermolecular manner deepli investig notabl exampl interfac locat high conserv rad protein part mre rad nbs mrn complex zn ii requir homodimer zn rad high stabil zn rad conserv protein deriv thermophil archaeon pyrococcus furiosus log k amino acid long fragment first one studi also human paralog studi log k amino acid long fragment report previous extrem high stabil result metal coupl fold process particular rad protein fragment play critic role sequenc structur stabil analysi base human rad present separ individu structur compon increas stabil complex point amino acid residu far away zn ii bind site larg respons complex stabil influenc individu compon well reflect previous publish crystal structur human rad zinc hook pdb gox addit herebi report effect phosphoryl zinc hook domain exert destabil effect domain studi identifi factor govern stabil metal mediat protein protein interact illumin molecular basi | D004268;D020027 | T123;T116;T194 |
36,232,440 | potenti sulforaphan broccoli membran vesicl regul mm human macrophag activ macrophag emerg import therapeut target mani human diseas aim studi analyz effect broccoli membran vesicl sulphoraphan sfn either free encapsul activ human monocyt deriv macrophag primari cultur result show exposur h sfn free encapsul induc potent reduct activ human macrophag downregul proinflammatori anti inflammatori cytokin phagocyt capabl c albican broccoli membran vesicl repres inert nanocarri low amount bioactiv compound abl modul cytokin product depend inflammatori state cell could induc opposit effect higher dose sfn reflect hormet effect data reinforc potenti use broccoli compound therapeut agent inflammatori diseas also open new clinic possibl applic diseas relat immunodefici autoimmun cancer therapi consid variabl biolog effect differ scenario proper therapeut strategi brassica bioactiv compound design patholog | D001937 | T168;T002 |
36,232,439 | nuclear function kaea subunit keop complex aspergillus nidulan kae subunit high evolutionarili conserv keopsekc complex involv univers ta trna modif sever report discuss particip complex transcript regul yeast human cell includ previous observ kaea aspergillus nidulan homologu kaep aim project confirm role kaea transcript employ high throughput transcriptom rna seq chip seq proteom lc ms analysi confirm kaea subunit keop complex nidulan analysi kaea kaea mutant show although ta trna modif unaffect mutant reveal signific alter transcriptom compar wild type find kaea local chromatin identifi protein partner allow us postul addit nuclear function protein data shed light univers bi function role factor prove activ protein limit trna modif cytoplasm also affect transcript activ number nuclear gene data avail via ncbi geo databas identifi gse rna seq gse chip seq via proteomexchang identifi pxd proteom | D001233 | T004 |
36,232,438 | intestin epitheli stat activ rescu defect anti helminth respons caus ogt delet dynam regul intestin epitheli cell iec prolifer differenti crucial maintain mucosa homeostasi respons helminth infect glcnac transferas ogt enzym catalyz transfer glcnac donor substrat udp glcnac onto acceptor protein propos promot intestin epitheli remodel helminth expuls modifi activ epitheli stat whether iec intrins ogt stat axi involv anti helminth respons test vivo show induc delet ogt iec adult mice lead reduc tuft goblet cell differenti increas crypt cell prolifer aberr paneth cell local use mous model concurr ogt delet stat overexpress iec provid direct vivo evid stat act downstream ogt control tuft goblet cell differenti iec howev epitheli ogt regul crypt cell prolifer paneth cell differenti stat independ pathway result verifi protein glcnacyl iec crucial maintain epitheli homeostasi anti helminth type immun respons | D008463;D017351 | T121;T109;T126;T116 |
36,232,437 | identif optim tlr ligand altern posit ribos methyl recognit rna receptor innat immun system regul various posttransl modif differ singl ribos methyl shown convert tlrtlr ligand specif tlr ligand investig whether posit methyl crucial function end design differ methyl rna oligoribonucleotid orn investig immun activ various cell system analyz degrad rnase treatment found rrna deriv tlr ligand rna differenti digest result methyl lead variat tlr tlr inhibit suitabl certain methyl rna deriv tlr agonist demonstr fact rna sequenc weak tlr agonist thus abl identifi specif methyl rna deriv optim tlr ligand | D051199;D051200 | T192;T116;T129 |
36,232,436 | genom wide identif express analysi mapk gene famili lettuc lactuca sativa l function analysi lsmapk high temperatur induc bolt mitogen activ protein kinas mapk pathway wide distribut signal cascad eukaryot involv regul plant growth develop stress respons high temperatur frequent occur environment stressor caus prematur bolt lettuc qualiti declin yield loss howev whether mapk play role thermal induc bolt remain poor understood studi lsmapk famili member identifi lettuc genom physic chemic properti subcellular local chromosom local phylogeni gene structur famili evolut cis act element phosphoryl site lsmapk gene famili evalu via silico analysi accord phylogenet relationship lsmapk divid four group b c support analys gene structur conserv domain collinear analysi show collinear pair among lsmapk atmapk slmapk predict cis act element potenti phosphoryl site close associ hormon stress resist growth develop express analysi show lsmapk respond high temperatur among lsmapk signific continu upregul upon heat treatment heat stress stem length lsmapk knockdown line signific shorter control plant microscop observ demonstr differenti time flower bud stem apex delay accord therefor silenc lsmapk signific inhibit high temperatur acceler bolt lettuc indic lsmpak might potenti regul lettuc bolt studi provid theoret basi better understand molecular mechan under mapk gene high temperatur induc bolt | D018545;D020928 | T126;T168;T116;T002 |
36,232,435 | magneto mechan approach biomedicin benefit challeng futur perspect magneto mechan approach power techniqu use mani differ applic biomedicin includ remot control enzym activ cell receptor cancer select treatment mechan activ drug releas etc approach base use combin magnet nanoparticl extern magnet field led movement nanoparticl torqu forc enough chang conform biomolecul even break weak chemic bond howev despit mani theoret experiment work topic difficult predict magneto mechan effect particular case import result scatter often translat experi main reason magneto mechan effect extrem sensit chang paramet magnet nanoparticl environ chang paramet appli magnet field thus review summar propos simplifi theoret explan main factor affect effici magneto mechan approach discuss natur mnp mediat mechan forc order magnitud show main applic magneto mechan approach control properti biolog system | D060526;D053758 | T073;T070 |
36,232,434 | model dta combin multipl instanc learn privat public mechan predict strength drug target interact also call drug target bind affin dta play fundament role facilit drug discoveri goal find prospect drug candid increas number drug protein interact machin learn techniqu especi deep learn method becom applic drug target interact discoveri signific reduc requir experiment workload paper present spontan formul dta predict problem instanc multi instanc learn address problem three stage first organ given drug target sequenc instanc via privat public mechan identifi predict score instanc bag final combin predict score output predict comprehens evalu demonstr propos method outperform state art method three benchmark dataset | D000465;D000069550 | T170;T066 |
36,232,433 | molecular identif pro excitogen receptor channel phenotyp deaffer lumbar motoneuron earli phase sct rat spastic impact qualiti life patient suffer spinal cord injuri imped recoveri locomot cellular level spastic consid primarili caus hyperexcit spinal motoneuron mns within spinal stretch reflex circuit hypothes complet spinal cord transect rat fast adapt molecular respons lumbar mns develop return loss input assum earli loss glutamaterg affer chang express glutamaterg ampa nmda receptor subunit may forerunn develop spastic hindlimb muscl better understand molecular underpin concomit express gaba glycinerg receptor serotoninerg noradrenerg receptor regul persist inward current crucial sustain discharg mns examin togeth voltag gate ion channel cation chlorid cotransport use quantit real time pcr show tracer identifi mns innerv extensor flexor muscl ankl joint multipl increas transcript code ampar htr subunit along profound decreas gaba r glyr subunit kcc studi demonstr mns group similar adapt excit state may increas occurr extensor flexor muscl spasm | D013119;D027981 | T123;T116;T037 |
36,232,432 | fc receptor activ monocyt promot b lymphocyt migrat iga isotyp switch patient inflammatori bowel diseas ibd produc enhanc immunoglobulin iga microbiota compar healthi individu correl diseas sever sinc iga complex potent activ myeloid cell via iga receptor fcri cd excess iga product may contribut ibd patholog howev cellular mechan contribut dysregul iga product ibd poor understood demonstr intestin fcri express myeloid cell ie monocyt neutrophil close contact b lymphocyt lamina propria ibd patient furthermor stimul fcri monocyt trigger product cytokin chemokin regul b cell differenti migrat includ interleukin il interleukin il tumour necrosi factor tnf prolifer induc ligand april chemokin ligand ccl vitro cytokin promot iga isotyp switch human b cell moreov nave b lymphocyt cultur vitro presenc fcri stimul monocyt enhanc iga isotyp switch observ compar b cell cultur non stimul monocyt taken togeth fcri activ monocyt produc cocktail cytokin well chemokin stimul iga switch b cell close contact b cell myeloid cell observ colon ibd patient hypothes ibd iga complex activ myeloid cell turn result excess iga product like contribut diseas patholog interrupt loop may therefor repres novel therapeut strategi | D015212;D016753 | T047;T116;T129 |
36,232,431 | molecular dock silico analysi natur biomolecul dengu ebola zika sar cov variant concern monkeypox virus emerg rapid evolut human pathogen virus combin difficulti develop effect vaccin underlin need develop innov broad spectrum antivir therapeut agent present studi aim determin silico antivir potenti six bacteri antimicrobi peptid amp two phytochem silvestrol andrographolid two bacteri secondari metabolit lyngbyabellin hapalindol h dengu virus zika virus ebola virus major variant sar cov monkeypox virus comparison dock score obtain natur biomolecul perform specif neutral antibodi posit control cluspro antivir drug negat control autodock vina glycocin f natur biomolecul test show high bind energi viral surfac protein correspond viral cell receptor lactococcin g plantaricin asm also achiev high dock score viral surfac protein correspond cell surfac receptor silvestrol andrographolid hapalindol h lyngbyabellin show variabl dock score depend viral surfac protein cell receptor test three glycocin f mutant amino acid modif show increas dock energi spike protein sar cov b indian variant sar cov p japanbrazil variant dengu denv envelop protein mutant amp indic frequent occurr valin prolin amino acid rotam amp glycocin f particular promis biomolecul develop broad spectrum antivir treatment target attach entri virus target cell | D000086382;D003715;D019142;D000071244 | T047;T067;T005 |
36,232,430 | biolog treatment pediatr psoriasi state art futur perspect psoriasi chronic system inflammatori diseas primarili affect skin associ multipl comorbid consider reduct qualiti life affect patient one third psoriasi case begin childhood associ signific medic comorbid obes metabol syndrom arthriti psychiatr disord addit chronic natur frequent relaps psoriasi tend requir long term treatment treatment pediatr psoriasi usual involv method use adult howev treatment pediatr psoriasi use label research regard still lack target therapi involv use newli develop biolog drug also increas appli childhood psoriasi review summar clinic featur pediatr psoriasi focus main updat concept pathogenesi biolog treatment pediatr psoriasi | D001688;D011565 | T121;T047;T123 |
36,232,429 | spatial reorgan liquid crystallin domain red blood cell type diabet patient peripher arteri diseas work investig red blood cell rbc membran fluiditi influenc sever hyperglycemia induc pathway could provid complementari index hbac monitor develop type diabet mellitus tdm relat macroangiopath complic peripher arteri diseas pad contextu liquid crystallin lc domain spatial organ membran analys investig phase dynam transit twenti seven patient long durat tdm recruit classifi dm includ non pad patient dm pad includ patient stage pad mean valu rbc general polar gp repres membran fluiditi togeth spatial organ lc domain compar two group p valu lt consid statist signific although compar anthropometr characterist durat diabet hbac rbc membran pad patient found signific fluid gp non pad patient gp alter shown trigger chang lc microdomain composit distribut found decreas feret diamet dm dm pad increas circular alter rbc membran fluiditi correl spatial reconfigur lc domain possibl alter metabol function associ develop tdm relat macroangiopath complic | D003924;D058729 | T047 |
36,232,428 | meta analysi identifi bdnf novel common gene differ alter cross speci model rett syndrom rett syndrom rtt rare disord one abund caus intellectu disabl femal singl mutat gene code methyl cpg bind protein mecp respons disord mecp regul gene express transcript regul well epigenet imprint chromatin condens consequ numer biolog pathway multipl level influenc howev exact molecular pathway genotyp phenotyp current fulli elucid treatment rtt pure symptomat curat option rtt yet reach clinic pauciti main due incomplet understand under pathophysiolog disord clinic use common diseas driver biomark therapeut target identifi premis identifi univers robust diseas driver therapeut target interrog rang rtt transcriptom studi span differ speci model mecp mutat meta analysi use rna sequenc data brain rtt mous model human post mortem brain tissu patient deriv induc pluripot stem cell ipsc neuron perform use weight gene correl network analysi wgcna studi identifi modul gene common dataset follow ten hub gene drive express atrx adci adci sod cacnaa plcg cct rps bdnf mecp discuss potenti benefit gene therapeut target | D015518 | T047 |
36,232,427 | rare case success treat doubl valv infect endocard caus pseudomona aeruginosa pseudomona aeruginosa rare yet particular aggress infect endocard pathogen describ case success manag doubl valv p aeruginosa infect endocard presum sourc bacteremia long term tunnel central venous cathet use hemodialysi | D016470;D004696;D004697 | T047 |
36,232,426 | later growth cessat increas freez toler potenti result later dormanc evergreen iri compar decidu iri winter dormanc protect surviv strategi plant resist harsh natur environ context global warm progress dormanc signific affect perenni requir research systemat studi perform compar induct dormanc two close relat iri speci ecodorm process evergreen iri japonica thunb decidu iri tectorum maxim artifici condit first morpholog physiolog observ evalu ensur development status two iri speci furthermor express pattern gene involv key pathway relat plant winter dormanc determin correl analys dormanc marker gene conduct found decidu iri enter dormanc earlier evergreen iri artifici dormanc induct condit phytohormon carbohydr play role coordin growth stress respons dormanc induct iri speci moreov dormanc relat mad box gene snrks snf relat protein kinas might repres bridg carbohydr phytohormon interact iri dormanc find provid hypothet model explain later dormanc evergreen iri compar decidu iri artifici dormanc induct condit reveal candid gene find studi could provid new insight research dormanc perenni plant ecodorm process contribut effect manag iri product postharvest storag ship | D031323;D010937 | T125;T116;T002 |
36,232,425 | ambra pglnarg mutat identifi cowden syndrom famili exhibit hyperprolif potenti htert rpe cell cowden syndrom cs rare autosom domin disord associ multipl hamartomat neoplast lesion various organ cs patient found germlin mutat pten tumor suppressor present studi investig causat gene cs famili pten phosphatas tensin homolog delet chromosom negat cs patient whole exom sequenc analysi reveal ambra autophagi beclin regul novel candid gene harbor two germlin variant pglnarg qr pargser rs ambra key regul autophagi signal network tumor suppressor function valid role ambra clinic manifest cs generat ambra deplet qr mutat htert rpe humantelomeras revers transcriptas immort retin pigment epitheli cell use crispr cas gene edit system observ ambra deplet mutant cell show accumul phase lead hyperprolifer characterist hamartomat lesion specif ambra qr mutat disturb gs transit cell lead continu mitot entri mutant cell irrespect extracellular condit analysi primari ciliogenesi cell specul mitot entri ambra qr mutant could due non function primari cilia lead impair process extracellular sensori signal addit observ situs inversus phenotyp ambra deplet zebrafish development abnorm result dysregul primari ciliogenesi taken togeth establish ambra qr mutat observ cs patient might play import role induc hyperprolif potenti cell regul primari ciliogenesi | D006223 | T191;T047 |
36,232,424 | antivirul activ umbelliferon protect effect hydrophila infect grass carp hydrophila import pathogen main harm aquat anim exhibit resist varieti antibiot seek effect altern antibiot effect umbelliferon um sub mic hydrophila virul factor quorum sens system studi subsequ rna sequenc employ explor potenti mechan antivirul activ umbelliferon meanwhil protect effect umbelliferon grass carp infect hydrophila studi vivo result indic umbelliferon could signific inhibit hydrophila virul hemolysi biofilm format swim swarm motil quorum sens signal ahl ai transcriptom analysi show umbelliferon downregul express level gene relat exotoxin secretori system tss tss iron uptak etc anim studi demonstr umbelliferon could signific improv surviv grass carp infect hydrophila reduc bacteri load various tissu amelior cardiac splenic hepatopancrea injuri collect umbelliferon reduc pathogen hydrophila potenti drug treat hydrophila infect | D002347;D005393;D016905 | T047;T013 |
36,232,423 | identif express analysi nitraria sibirica pall auxin respons factor arf gene famili nitraria sibirica shrub surviv extrem drought environ auxin respons factor arf class transcript factor wide involv plant growth develop well regul stress resist howev genom wide identif arf gene famili respons environment stress especi drought stress n sibirica yet report identifi total arf gene genom n sibirica distribut chromosom divid three clade intragenom synteni analysi reveal one collinear gene pair arf gene famili ie nsarfa nsarfb cis act element analysi show multipl hormon stress respons cis act element found promot nsarf suggest nsarf may involv multipl biolog process quantit real time pcr qrt pcr show mani nsarf tissu specif express pattern highest express nsarf seedl n sibirica addit nsarf upregul drought independ endogen aba biosynthesi wherea respons nsarf nsarfa drought disrupt aba biosynthesi inhibitor fluridon studi provid basi research nsarf n sibirica respond hormon signal environment stress | D007210;D019684 | T109;T123;T002 |
36,232,422 | conveni way quinoxalin deriv reaction oxoindolin yl phenylacetonitril benzen diamin microwav assist reaction oxoindolin yl phenylacetonitril andbenzen diamin lead high yield format correspond quinoxalin sole easili isola product featur transform involv unusu extrus phenylacetonitril molecul could perform short sequenc start common avail indol nitroolefin | D003959;D011810 | T109 |
36,232,421 | low dose non target radiat effect environment protect medicin new model focus electromagnet signal role signal initi perpetu effect trigger deposit ionis radiat energi part system clear less clear earli step involv convert energi chemic biolog effect non target part system paper aim present new model could aid understand role low dose effect determin ultim diseas outcom propos key role electromagnet signal result physico chemic process excit decay acoust wave lead initi damag respons pathway elev reactiv oxygen speci membran associ chang key ion channel critic signal pathway allow coordin respons across system level exampl depend perturb transduc advers benefici outcom may predomin suggest appreci import signal communic multipl level organis unifi theori could emerg would allow develop model incorpor time space system level posit data appropri area multidimension domain propos use term infosom captur natur radiat induc communic system includ physic well chemic signal name model variabl respons model vrm allow multipl outcom follow exposur low dose signal low dose irradi cell tissu organ suggest use dose infosom radiat protect might open new conceptu avenu could allow intrins uncertainti embrac within holist protect framework | D024201;D011832 | T043;T037;T047 |
36,232,420 | cd cd nkt like cell show imbalanc control immedi exercis delay onset muscl sore purpos studi carri immunophenotyp character special focus natur killer cell junior swimmer hungarian nation swim team intens acut exercis nineteen swimmer ten femal nine male complet exercis protocol sixteen swimmer experienc delay onset muscl sore find substanti earlier result increas percentag cd cd natur killer cell cd cd dim nk cell decreas percentag cd cell among lymphocyt exercis protocol drop natur killer cell activ back pre exercis level line earlier find interest percentag cd cd nkt like cell chang signific three swimmer report delay onset muscl sore contrari percentag cd cd nkt like cell among lymphocyt increas fourteen decreas two swimmer report delay onset muscl sore studi first time demonstr link delay onset muscl sore imbalanc control cd cd nkt like cell among lymphocyt howev valid associ larger sampl size studi necessari | D055611 | T025 |
36,232,419 | surfactin mitig high fat diet streptozotocin induc type diabet improv pancreat dysfunct inhibit inflammatori respons surfactin bacillus amyloliquefacien fmb util treat mice type diabet tdm induc high fat dietstreptozotocin hfdstz group earlier research indic surfactin could lower blood glucos mitig liver dysfunct improv hfdstz induc tdm modul intestin microbiota thus investig effect surfactin pancrea colon mice tdm elucid detail mechan present studi mice hfdstz induc tdm pancreat colon inflamm oxid stress endoplasm reticulum stress er reduc given oral surfactin dose mgkg bodi weight accord research surfactin also improv glucos metabol activ phosphatidylinositol kinas pik protein kinas b akt signal pathway protect islet cell promot insulin secret inhibit glucagon releas mitig pancrea dysfunct addit surfactin treatment colon level tight junction protein occludin claudin tdm mice consider increas respect find reveal surfactin amelior hfdstz induc pancrea inflamm dysfunct preserv intestin barrier dysfunct gut microbiota homeostasi also enhanc insulin sensit glucos homeostasi tdm mice final experi abl demonstr earli surfactin intervent might delay develop tdm caus hfdstz accord critic biochem paramet serum | D003921;D003924;D007333 | T050;T047;T046 |
36,232,418 | somat mutat landscap mexican patient cdh mutat chrq amplif associ diffus type gastric adenocarcinoma hispan popul compar ethnic group present aggress gastric cancer phenotyp higher frequenc diffus type gastric adenocarcinoma ga could relat mutat landscap ga patient use whole exom sequenc sought present mutat landscap ga mexican patient treat instituto nacion de cancerologa perform comprehens statist analysi explor relationship genom variant clinic data tumor histolog presenc signet ring cell h pylori ebv describ potenti differ mutat landscap diffus intestin ga mexican patient patient intestin type ga tend present higher frequenc notch mutat copi number gain cytoband q q copi number loss cytoband p q q wherea patient diffus type ga tend present high frequenc cdh mutat cnv gain cytoband q q first descript mutat landscap ga mexican patient better understand tumorigenesi hispan patient lay groundwork discov potenti biomark therapeut target | D000230;D016480;D013274 | T191;T007 |
36,232,417 | effect hydrogel contact angl wall thick artifici blood vessel vascular replac one effect tool solv cardiovascular diseas due limit autolog transplant size mismatch etc blood vessel replac often short suppli emerg artifici blood vessel bioprint expect solv problem blood vessel prosthesi play import role field cardiovascular medic materi howev small diamet blood vessel prosthesi diamet lt mm still unabl achiev wide clinic applic paper respons surfac analysi first util obtain relationship contact angl gelatinsodium algin mix hydrogel solut differ temperatur mass percentag self develop bioprint use obtain optim print space differ condit row space print verifi relationship contact angl print thick final relationship blood vessel wall thick contact angl obtain biofabr bioprint also confirm control vascular membran thick mold lay foundat follow studi small calib blood vessel print mold experi | D062028;D001802 | T121;T063 |
36,232,416 | metabol potenti gut microbiom signific impact condit regimen allogen hematopoiet stem cell transplant recipi allogen hematopoiet stem cell transplant ahsct putat curat treatment malign hematolog disord transplant immun system suppressederad condit regimen non myeloabl myeloabl replac donor immun system previous studi show chang gut taxonom profil decreas bacteri divers post transplant studi expand cohort patient focus impact condit regimen taxonom featur metabol function gut bacteria knowledg first studi examin metabol potenti gut microbiom patient group adult ahsct recipi shotgun sequenc stool sampl collect day relat ahsct includ one sampl select per patient per period pre ahsct day post ahsct day total patient sampl includ speci rich alpha divers gene rich metabol rich lower post ahsct pre ahsct declin pronounc myeloabl group myeloabl group show declin genera increas genera non myeloabl group genera decreas increas lower fold chang observ myeloabl group myeloabl group bacteri metabol function decreas one function increas non myeloabl group three function decreas two function increas henc chang taxonomi post ahsct caus profound declin bacteri metabol function especi myeloabl group thus provid new evid associ myeloabl condit gut dysbiosi function perspect | D000069196;D019337;D018380 | T007;T001;T061;T191 |
36,232,415 | construct de pattern plasma protein aspect potenti tumor marker use tumor marker aid earli detect cancer recurr prognosi hope might also use screen test earli detect cancer question find ideal tumor marker sensit specif reliabl acut issu human plasma one popular sampl common collect clinic provid noninvas rapid analysi type diseas includ cancer mani effort appli search ideal tumor marker dig deep plasma proteom situat area improv two way attempt find ideal singl tumor marker generat panel differ marker case proteom certain play major role line evid abund call classic plasma protein may use generat tumor biomark profil comprehens profil inform protein level also proteoform distribut protein initi profil protein norm generat work collect bibliograph inform connect cancer level classic plasma protein addit present proteoform profil de pattern protein norm generat two dimension electrophoresi mass spectrometri immunodetect next step similar profil repres protein perturb plasma produc case differ cancer generat addit base inform differ test system develop | D009369;D020543 | T191;T123;T116 |
36,232,414 | consequ autophagi delet age relat chang epiderm lipidom mice autophagi control mechan intracellular self digest function metabol adapt stress develop proteostasi maintain cellular homeostasi age delet autophagi epiderm keratinocyt prevent format function epidermi permeabl barrier caus increas suscept damag stress metabol alter acceler age phenotyp investig epiderm autophagi defici use keratin driven atg delet would affect lipid composit epidermi young old mice use mass spectrometr lipidom found reduct age relat accumul storag lipid epidermi autophagi defici mice specif chang chain length satur fatti acid sever lipid class transcriptom immunostain suggest chang accompani chang express localis lipid fatti acid transport protein notabl fatti acid bind protein fabp autophagi knockout thus maintain autophag activ advanc age may necessari maintain epiderm lipid homeostasi mammal | D004817;D000081362 | T091;T024;T109 |
36,232,413 | predict rank biomark use multipl unir protein protein interact ppis key import understand cell organ function thus recent decad mani approach develop identif discoveri interact approach address problem ppi identif either experiment point view comput one present updat version unir comput predict tool take advantag biomed literatur aim extract document alreadi publish protein associ predict undocu one use comput tool previous evalu experiment valid predict interact benchmark public databas experiment valid ppis updat form unir allow user provid list protein known implic eg particular diseas well anoth list protein potenti associ protein first list unir automat analyz list rank protein second list associ protein first list thus serv potenti biomark discoveryvalid tool | D025941;D011506 | T116;T123;T063 |
36,232,412 | gut immun brain axi import rout neuropsychiatr morbid inflammatori bowel diseas inflammatori bowel diseas ibd compris crohn diseas cd ulcer coliti uc associ neuropsychiatr symptom like anxieti depress condit strong worsen ibd diseas burden present review summar current understand pathogenesi depress anxieti ibd present stepwis cascad along gut immun brain axi initi evas chronic intestin inflamm pass epitheli vascular barrier gut caus system inflamm summar differ anatom transmiss rout gut deriv peripher inflamm central nervous system cns highlight current knowledg neuroinflammatori chang cns preclin ibd mous model focus microglia brain resid macrophag subsequ discuss neuroinflamm ibd alter neuron circuitri trigger symptom like depress anxieti final role intestin microbiota gut immun brain axi ibd review comprehens understand interact gastrointestin tract immun system cns account similar differ uc cd pave path improv predict treatment neuropsychiatr comorbid ibd inflammatori diseas | D003093;D003424;D015212 | T047 |
36,232,411 | genom wide character express analysi fatti acid desaturas gene famili poplar fatti acid desaturas fad modul carbon carbon singl bond form carbon carbon doubl bond acyl chain lead unsatur fatti acid ufa vital role plant growth develop respons environment stress studi total populus trichocarpa fad ptfad candid identifi poplar genom cluster seven clade includ fab fad fad fad fad dsd sld exon intron composit conserv motif ptfad cluster clade consider conserv found segment duplic event predomin attribut ptfad gene famili expans sever hormon stress respons element ptfad promot impli express ptfad member complic regul gene express pattern analysi reveal ptfad mrna level signific induc abiot stress interact protein gene ontolog go analysi indic ptfad close associ ufa biosynthesi addit ufa content poplar signific chang drought salt stress especi ratio linol linolen acid integr ptfad express pattern ufa content show abiot stress induc ptfad member mediat convers linol linolen acid play vital role respons osmot stress studi highlight profil function ptfad identifi valuabl gene forest improv | D044943;D032107 | T126;T116;T002 |
36,232,410 | role fatti acid bind protein character atrial fibril predict outcom cathet ablat util biomark character atrial cardiomyopathi unclear aim test abil biomark fibrosi galectin gal adipos fatti acid bind protein fabp leptin predict presenc low voltag area lva electroanatom voltag map recurr atrial fibril af pulmonari vein isol pvi | D001281;D017115;D011667 | T061;T047;T046;T023 |
36,232,409 | identif character auxin respons factor gene famili reveal regulatori network respond multi hormon crosstalk ga induc grape parthenocarp berri exogen gibberellin ga wide use improv berri qualiti induc parthenocarp seedless berri grape reveal auxin respons factor arf key transcript factor respons auxin might respond ga involv modul grape parthenocarpi howev under molecular mechan process remain yet unclear total vvarf member identifi ovari ga induc grape parthenocarpi interest almost member ga respons factor could classifi plant hormon signal transduct ko involv tryptophan metabol pathway k moreov vvarf predict interact protein involv kegg pathway interact protein particip ko pathway includ auxin iaa salicyl acid sa abscis acid aba cytokinin ctk ethylen signal pathway respond ga mediat multi hormon crosstalk analysi demonstr vvarf might major factor modul ga induc parthenocarpi via crosstalk iaa ctk sa ethylen signal follow vva rf vvarf involv sa aba signal pathway respect final develop vvarf mediat regulatori network respond ga mediat multi hormon crosstalk grape parthenocarpi collect find provid novel insight regulatori network vvarf ga guid multi hormon signal modul grape parthenocarpi great implic molecular breed high qualiti seedless grape berri | D027843 | T168;T116;T002;T129 |
36,232,408 | rhamnolipid micel adsorpt properti biosurfact natur occur amphiphil activ pursu altern synthet surfact clean person care cosmet product basi abil mobil dispers hydrocarbon biosurfact also involv bioremedi oil spill rhamnolipid low molecular weight glycolipid biosurfact consist mono di rhamnos head group hydrocarbon fatti acid chain examin micel purifi mono rhamnolipid di rhamnolipid aqueous solut adsorpt model solid surfac rhamnolipid micel water endotherm cmc critic micel concentr di rhamnolipid lower mono rhamnolipid cmcs decreas upon nacl addit rhamnolipid adsorpt gold surfac most revers adsorb layer rigid better understand biosurfact self assembl adsorpt properti import util consum product environment applic | D012210;D012965 | T121;T109;T123;T196;T197;T130 |
36,232,407 | shp stat signal axi regul coupl becn slca contribut sorafenib induc ferroptosi hepatocellular carcinoma ferroptosi type iron depend cell death pertain excess lipid peroxid suggest sorafenib anti angiogen medic hepatocellular carcinoma hcc induc ferroptosi under mechan remain larg unknown employ sirna mediat gene silenc investig role src homolog region domain contain phosphatas shp follow sorafenib treatment cystineglutam antiport system xc regul cystin uptak co immunoprecipit also perform examin interact mcl beclin becn solut carrier famili member slca function catalyt subunit system xc result studi show sorafenib enhanc activ shp dephosphoryl stat downregul express mcl consequ reduc associ mcl becn contrast increas bind becn slca observ follow sorafenib treatment elev interact becn slca inhibit activ system xc wherea becn silenc restor cystin intak protect cell ferroptosi notabl ectop express mcl uncoupl becn slca rescu cell viabil attenu lipid peroxid result reveal ferroptosi could induc hcc via shp stat mediat downregul mcl subsequ inhibit slca increas becn bind | D006528;D000079403;D008113 | T191;T043 |
36,232,406 | isol sequenc chromosom arm rs rye secal cereal rye secal cereal climat resili cereal grown extens grain forag crop northern eastern europ addit import crop use improv wheat introgress genom region improv yield diseas resist understand genom divers rye assist improv crop facilit introgress valuabl trait wheat isol sequenc short arm rye chromosom rs tritical sd use flow cytometri compar public lo rye whole genom refer assembl identifi lo gene present isol chromosom arm two cluster contain seven sixti five gene present tritical sd rs absent lo rs identifi gene assign chromosom locat lo assembl present tritical sd rs suggest chromosom arm locat gene studi support lo refer assembl provid repertoir gene tritical rs | D012434;D000066889 | T002 |
36,232,405 | approach measur activ major lipolyt lipogen enzym vitro ex vivo sinc one goal adipos tissu research determin lipolyt lipogen activ primari metabol pathway affect adipocyt health size thus repres potenti therapeut target treatment obes associ diseas nowaday relat larg number method measur activ pathway involv enzym applic differ biolog sampl variabl review characterist mean lipogen lipolyt enzym inhibitor avail methodolog assess activ comment advantag disadvantag methodolog applic vivo ex vivo vitro ie cell organ respect extract emphasi adipocyt adipos tissu | D050155;D008066 | T040 |
36,232,404 | molecular character snp base molecular marker develop two novel high molecular weight glutenin gene triticum spelta l spelt wheat triticum spelta l nx aabbdd valuabl sourc new gene resourc wheat genet improv present studi two novel high molecular weight glutenin subunit hmw gs ax glu glu b german spelt wheat identifi encod gene subunit amplifi clone allel specif pcr pcr complet sequenc open read frame orf obtain ax bp bp encod amino acid residu respect molecular character show subunit longer repetit region high percentag helic n c termini benefici form superior gluten macropolym protein model alphafold reveal similar three diamension structur featur ax two x type superior qualiti subunit ax ax four type superior qualiti subunit four cystein residu three x type subunit ax ax ax cystein intermedi repeat region type subunit expect particip intramolecular disulfid bond format cystein might form intermolecular disulfid bond glutenin gliadin enhanc gluten macropolym format snp base molecular marker ax gene develop verifi differ f popul recombin inbr line ril deriv cross spelt wheat bread wheat cultivar studi provid data new glutenin gene molecular marker wheat qualiti improv | D003545;D014908 | T116;T002;T121;T123;T168 |
36,232,403 | molecular mechan cellular injuri role toxic heavi metal chronic kidney diseas chronic kidney diseas ckd progress diseas affect million adult everi year major risk factor includ diabet hypertens obes affect million adult worldwid ckd character cellular injuri follow perman loss function nephron injur cell die nephron becom sclerot remain healthi nephron attempt compens undergo various structur molecular function chang chang design maintain appropri renal function may lead addit cellular injuri progress diseas ckd progress filtrat decreas abil elimin metabol wast environment toxic declin inabl elimin environment toxic arsenic cadmium mercuri may contribut cellular injuri enhanc progress ckd present review describ major molecular alter contribut pathogenesi ckd effect arsenic cadmium mercuri progress ckd | D001151;D008628;D019216;D051436 | T121;T131;T196;T047 |
36,232,402 | vitamin weight chang mendelian random prospect studi associ hydroxyvitamin year weight chang assess popul base prospect studi conduct lausann switzerland data first n women second n women third n women follow up use weight genet risk score grs snps associ vitamin level construct baselin grs correl posit hydroxyvitamin level base spearman rank correl confid interv p lt bodi mass index p associ found quartil grs weight chang year multivari adjust weight chang sem year follow kg first fourth quartil grs respect p two step linear regress show signific clinic meaningless associ grs deriv vitamin weight chang year slope confid interv nmoll increas grs deriv hydroxyvitamin level kg respect conclud littl associ genet determin hydroxyvitamin level weight gain | D057182;D014808 | T047;T062 |
36,232,401 | trpv receptor regul sphingosin phosphat implic anandamid depend regul mitochondri activ cc myoblast sphingosin phosphat sp endocannabinoid ec system comprehend bioactiv lipid wide involv regul similar biolog process interact sp ec far investig skelet muscl system activ use murin cc myoblast investig effect sp ec element qrt pcr western blot uhplc ms addit modul mitochondri membran potenti jc mitotrack red cmx ros fluoresc dye well level protein control mitochondri function along oxygen consumpt assess western blot respirometri respect cell treatment methanandamid maea presenc sp antagonist endocannabinoid bind receptor sp induc signific increas trpv express mrna protein level reduc protein content cb dose depend effect maea mediat trpv evidenc particular low dose respons increas wherea high dose negat modul cell surviv moreov maea induc hyperpolar counteract sp find open new dimens sp endocannabinoid cross talk skelet muscl identifi trpv pivot target | D063388;D005456 | T109;T123;T130 |
36,232,400 | evalu sensit breast cancer cell line cardiac glycosid unveil atpb possibl biomark person treatment er express breast cancer molecular classif breast cancer bc dictat pharmacolog treatment estrogen receptor er express tumor treat oh tamoxifen fulvestr inhibit receptor aromatas inhibitor ie anastrozol letrozol exemestan reduc estradiol e circul blood level besid endocrin therapi et drug er posit bcs treat epiderm growth factor receptor egf r inhibitor ie gefitinib erlotinib lapatinib accord express notwithstand anti bc drug novel person approach bc treatment requir prolong administr pharmaceut determin resist phenotyp result metastat bc recent report cardiac glycosid cg ie nak atpas inhibitor ouabain could repurpos er posit primari metastat bc treatment induc er degrad kill bc cell evalu cgs could repres addit treatment option er posit bcs nak atpas could consid biomark er posit bc treatment result indic atpb nak atpas isoform educ choic person treatment er posit bc cgs cgs could efficaci administ associ gefitinib | D001943;D002301 | T191;T109;T121 |
36,232,399 | format uniqu placent seed capsul matur process tomato fruit morpholog anatom studi seed format featur juici tomato fruit carri ovul form placenta shown gradual envelop protrus placent tissu aris simultan result process seed enclos individu capsul seed capsul shown vivo airtight air fill tomato seed shown studi develop insid capsul full matur fruit come contact detach molder cell placenta protrus convert gel pulp use scan electron microscopi possibl reveal detail ribbon like pubesc format tomato seed well understand mechan crack outer layer cell seed coat associ detect calcium oxal crystal cell uniqu outer layer tomato seed coat seem play role scaffold maintain constant volum protect capsul | D018551 | T168;T002 |
36,232,398 | mast cell dendrit cell cellular immun checkpoint immunotherapi solid tumor immun checkpoint inhibitor revolution cancer immunotherapi inhibitor game changer mani cancer mani patient sometim show unpreced therapeut efficaci howev therapeut efficaci larg limit mani solid tumor tumor control immun microenviron prevent immun system effici reach recogn elimin cancer cell tumor immun microenviron larg orchestr immun cell tumor gain resist immun system among cell mast cell dendrit cell cell type possess enorm capabl shape immun microenviron capabl stage cell cellular checkpoint immun microenviron regain control cell tumor microenviron open new avenu break resist solid tumor immunotherapi review discuss mast cell dendrit cell context solid tumor immun cell alon cooper modul solid tumor resist immun system also discuss modul could use novel immunotherapeut modal weaken solid tumor resist immun system weaken could help immunotherapeut modal engag tumor effici | D008407;D009369 | T191;T025 |
36,232,397 | cellular molecular target acut ischem stroke despit avail treatment strategi ischem stroke still lead caus death disabl worldwid | D002545;D000083242;D020521 | T047;T046 |
36,232,396 | unorthodox pcna bind chromatin assembl factor eukaryot dna replic fork hub enzym continu act synthes dna propag dna methyl epigenet mark perform qualiti control repair nascent dna packag dna chromatin mani enzym involv spatiotempor correl process perform function bind prolifer cell nuclear antigen pcna long stand question plethora pcna bind enzym exert activ without interf first step toward deciph complex regul studi chromatin assembl factor caf bind pcna demonstr caf bind pcna heretofor uncharacter manner depend upon cation pi interact arginin residu conserv among caf homolog absent pcna bind protein insert hydrophob pocket normal occupi protein contain canon pcna interact peptid pip mutat arginin disrupt abil caf bind pcna assembl chromatin pip caf p subunit resid extrem c terminus appar long helix amino acid report bind dna length helix presenc pip c terminus evolutionarili conserv among numer speci rang yeast human arrang long dna bind coil coil termin pip may serv coordin dna pcna bind caf | D002843;D004261 | T045;T116 |
36,232,395 | hyperbar oxygen therapi allevi social behavior dysfunct neuroinflamm mous model autism spectrum disord autism spectrum disord asd multifactori neurodevelopment disord ndd character impair social communic repetit behavior among symptom asd high herit shank one high risk gene asd recent year knowledg grow regard neuroplast effect induc hyperbar oxygen therapi hbot potenti use asd character effect hbot mous model asd human genet condit insg mutat shank gene compar placebo hbot improv social behavior reduc neuroinflamm cortex insg mice specif hbot induc upregul insulin like growth factor igf express level reduc number iba posit cell mous model asd compar placebo control togeth research suggest hbot potenti improv clinic outcom asd amelior core pathophysiolog process respons develop disord | D000067877;D006931 | T061;T048 |
36,232,394 | synthesi novel trifluoroanisol deriv contain phenylpyridin moieti herbicid activ find novel herbicid compound high activ broad spectrum seri phenylpyridin moieti contain trifluoroanisol deriv design synthes identifi via nuclear magnet reson nmr high resolut mass spectrometri hrms greenhous base herbicid activ assay reveal compound exhibit gt inhibitori activ abutilon theophrasti amaranthus retroflexus eclipta prostrat digitaria sanguinali setaria viridi dose g aihm better fomesafen compound exhibit excel herbicid activ abutilon theophrasti amaranthus retroflexus greenhous set respect median effect dose ed valu g aihm slight superior fomesafen ed g aihm respect half maxim inhibitori concentr ic compound fomesafen use inhibit nicotiana tabacum protoporphyrinogen oxidas nt ppo enzym nm dock result compound indic introduct chloro trifluoromethylpyridin trifluoromethoxi group benefici format stabl interact compound nt ppo work demonstr compound could optim ppo herbicid candid control various weed | D027721;D006540 | T131;T002 |
36,232,393 | neurotox effect doxorubicin treatment cardiac sympathet neuron doxorubicin doxo remain amongst common use anti cancer agent treatment solid tumor lymphoma leukemia howev clinic use hamper cardiotox character heart failur arrhythmia may requir chemotherapi interrupt devast consequ patient surviv qualiti life although advers cardiac effect doxo consolid under mechan still incomplet understood previous shown doxo lead proteotox cardiomyocyt cm death myocardi fibrosi mechan lead mechan electr dysfunct sever work focus cms culprit doxo induc arrhythmia heart failur recent studi suggest doxo may also affect cardiac sympathet neuron csns would thus repres addit cell target doxo cardiotox confoc immunofluoresc morphometr analys reveal alter sn innerv densiti topolog heart doxo treat mice consist reduc cardiotrop effect adrenerg neuron vivo ex vivo analys suggest doxo induc denerv may link reduc neurotroph input shown reli nerv growth factor releas innerv cms notabl similar alter observ explant heart doxo treat patient data demonstr chemotherapi cardiotox includ alter cardiac innerv unveil previous unrecogn effect doxo cardiac autonom regul involv cardiac physiolog patholog includ heart failur arrhythmia | D006333;D020258 | T047;T046;T037 |
36,232,392 | osmosmr interleukin famili cytokin physiolog patholog condit oncostatin osm member interleukin il famili cytokin bind two differ receptor leukemia inhibitori factor receptor lifr oncostatin receptor osmr complex contain common glycoprotein gp subunit | D016207;D015850 | T116;T129 |
36,232,391 | role rnaiii resist antibiot antimicrobi agent staphylococcus epidermidi biofilm staphylococcus epidermidi known opportunist pathogen one lead caus chronic biofilm associ infect biofilm format consid main strategi resist antibiot treatment help bacteria escap human immun system understand complex mechan biofilm format help find new way treat resist strain lower preval nosocomi infect order examin role rnaiii regul agr quorum sens system extent influenc biofilm resist antimicrobi agent delet mutant epidermidi rpa rnaiii defici repressor domain main function hld gene creat delet strain use examin influenc oxacillin combin vanillin biofilm resist cell surviv determin util real time qpcr confoc laser scan microscopi clsm crystal violet stain analys found rnaiii independ control phenol solubl modulin psms rnaiii effector molecul signific role biofilm resist antibiot phenol compound protect integr biofilm moreov combin antibiot antimicrobi agent induc methicillin resist epidermidi biofilm format lead exceed difficult medic treatment | D000890;D013203 | T121;T047 |
36,232,390 | role extracellular matrix human neurodegen diseas dens neuropil central nervous system leav limit space extracellular substanc free advent immunohistochemistri soon follow advanc diagnost tool enabl us explor biochem heterogen compartment brain extracellular matrix exploratori clinic research alik composit extracellular matrix critic shape neuron function chang assembl trigger reflect brainspin cord malfunct studi focus extracellular matrix chang neurodegen disord summar phenotyp appear biochem characterist well major enzym regul remodel matrix establish diseas specif built basement membran central nervous system perineuron net perisynapt axon coat protect neuron toxic agent biochem analysi reveal individu glycosaminoglycan proteoglycan compon interact molecul depend site type progress diseas select matrix compon either proactiv trigger format diseas specif harm product reactiv accumul like reduc tissu breakdown neuron loss review diagnost use increas import medic screen extracellular matrix compon especi enzym inform us diseas status better yet allow us forecast ill | D019636 | T047 |
36,232,389 | walnut shell biowast valor via htc process remov emerg pharmaceut pollut aqueous solut research emphas perform eco friend carbon materi hydrochar hc obtain hydrotherm carbon htc process appli walnut shell ws biowast materi display promis properti use environment applic emerg pharmaceut pollut retent water sourc thus three hydrochar code hcws hcws hcws obtain use dynam autoclav specif condit temperatur c autogen pressur biomass water weight ratio three differ reaction time h h h hcwss character mean atr ftir sem ed analys test possibl adsorb assess remov effici emerg pharmaceut pollut paracetamol methylen blue uv vis spectrophotometri kinet adsorpt studi carri best result obtain hcws hydrochar perspect includ activ step hydrochar test emerg pharmaceut pollut | D004785;D031324 | T131;T002 |
36,232,388 | senesc tumor cell anticanc therapi benefici detriment effect cellular senesc process result stabl cell cycl arrest prevent cell prolifer induc varieti stimuli includ metabol stress dna damag telomer shorten oncogen activ senesc general consid process tumor suppress prevent cancer cell prolifer inhibit cancer progress also key effector mechan mani type anticanc therapi chemotherapi radiotherapi direct bioactiv molecul releas senesc cell stimul immun respons senesc character senesc associ secretori phenotyp sasp benefici detriment impact cancer progress despit negat attempt still made use senesc fight cancer especi come senolyt possibl combin prosenesc therapi target tumor cell caus senesc senotherapi target senesc cell promis cancer treatment review provid inform cellular senesc connect carcinogenesi therapeut possibl link process | D016922;D009369 | T191;T043 |
36,232,387 | effect dri onion powder quercetin obes associ hepat menifest retinopathi onion allium cepa l rich flavonoid particular quercetin report anti obes properti under mechan associ health issu remain unclear studi compar effect dri onion powder quercetin high fat diet hfd induc obes nonalcohol fatti liver diseas retin neovascular briefli rat n per group divid control hfd alon fat hfd hfd w w hfd quercetin mgkg week bodi fat marker metabol fatti liver steatohepat retinopathi analyz result reveal dose depend suppress bodi weight viscer subcutan fat accumul epididym adipocyt hfd fed rat also decreas hfd induc alt ast free fatti acid glucos proinflammatori cytokin oxid stress group lower triglycerid total cholesterol proinflammatori cytokin level acc fatti acid synthesi associ enzym express higher hepat antioxid enzym activ fecal lipid exhibit better similar efficaci quercetin quercetin increas fecal level acet acid butyr acid similar also reduc lipid peroxid eye retin adipos neovascular howev quercetin result appar decreas regul rafmapk pathway eye specimen conclus suppress viscer subcutan liver fat accumul better quercetin like due higher fecal fat excret lower oxid stress proinflammatori cytokin level acc express quercetin regul signal pathway better reduc retin adipos neovascular | D065626;D012164 | T047 |
36,232,386 | breed feed system impact bioactiv anti inflammatori properti bovin milk present studi aim assess influenc breed feed system bovin milk profil betain carnitin milk capac counteract inflammatori endotheli cell ec damag induc interleukin il first experiment design two breed chosen holstein vs modicana investig biomolecul content antioxid capac milk dairi product second experiment design two feed system pastur vs total mix ratio test holstein evalu possibl effect function profil milk dairi product final bulk milk two experiment design use evalu efficaci prevent il induc endotheli inflammatori damag result show modicana milk whey higher biomolecul content antioxid activ compar holstein milk p lt milk holstein fed tmr show higher concentr butyrobetain valerobetain p lt l carnitin p lt similar whey holstein fed tmr also show higher content valerobetain glycin betain l carnitin acetyl l carnitin p lt compar holstein fed pastur convers antioxid activ milk dairi product affect feed system ec milk sampl reduc il induc cytokin releas well accumul reactiv oxygen speci ros induct cell death robust effect elicit modicana milk p lt overal modicana milk show higher content biomolecul antioxid activ compar holstein suggest breed feed system posit affect health promot profil dairi cattl milk | D000975;D008892 | T121;T123;T168;T044;T031;T039 |
36,232,385 | rhizobi type secret system dr jekyl mr hyde rhizobium legum symbiosi rhizobia soil bacteria establish symbiot associ legum result plant nodul form root host plant rhizobia differenti bacteroid capabl fix atmospher nitrogen ammonia ammonia transfer plant exchang carbon sourc appropri environ bacteri surviv process subject tight regul sever checkpoint allow progress infect restrict type secret system tss secretori system inject protein call effector te direct cytoplasm host cell alter host pathway suppress host defens respons secret system present rhizobia role symbiosi crucial symbiot associ show two possibl face dr jekyl mr hyde complet necessari format nodul block nodul differ legum speciescultivar review compil inform current avail effect differ rhizobi effector plant symbiot phenotyp phenotyp divers highlight import tss certain rhizobium legum symbios | D007887;D012231 | T007;T002 |
36,232,384 | tumor cell specif retent photodynam action erlotinib pyropheophorbid conjug enhanc uptak photosensit epitheli tumor cell target egfr pyropheophorbid deriv synthes erlotinib attach differ posit macrocycl although addit erlotinib reduc cellular uptak sever compound show prolong cellular retent maintain photodynam efficaci aim studi identifi whether erlotinib moieti assist tumor target interact egfr whether interact inhibit egfr kinas activ activ conjug analyz primari cultur human head neck tumor cell high level express egfr human carcinoma grown xenograft mice uptak erlotinib conjug correl cellular express egfr none compound exert egfr inhibitori activ one deriv erlotinib posit ps display enhanc tumor cell specif retent mitochondria improv pdt efficaci subset tumor case moreov upon treatment conjug therapeut light egfr inhibitori activ recov attenu egfr signal depend tumor cell prolifer find suggest tumor cell specif deposit erlotinib pyropheophorbid follow light trigger releas egfr inhibitori activ may improv photodynam therapi attenu tumor growth depend egfr deriv signal | D010778;D017319 | T121;T061;T039 |
36,232,383 | dual effect tryptamin prostat cancer cell growth regul pilot studi abnorm tryptophan metabol link cancer neurodegen diseas tryptophan metabolit report potenti prostat cancer pca biomark howev littl known bioactiv tryptophan metabolit pca cell growth studi mtt transwel assay use studi cytotox major tryptophan metabolit pca normal prostat epitheli cell line ultraperform liquid chromatographi high resolut mass spectrometri uplc hrms use analyz metabol chang cell treat tryptamin flow cytometri confoc imag western blot use test apoptosi induc tryptamin shown tryptamin obvious inhibitori effect pca cell line pc lncap stronger normal prostat cell line rwpe tryptamin shown induc apoptosi inhibit pc cell migrat metabol chang includ amino acid metabol relat cell prolifer metastasi found pc cell treat tryptamin furthermor pc xenograft mous model use studi effect tryptamin vivo intratumor inject tryptamin demonstr signific reduc tumor growth tumor size vivo howev intraperiton treatment result increas tumor growth dual effect vivo advanc understand bioactiv tryptamin regul prostat tumor develop addit major role neuromodul | D011467;D011471 | T191;T023 |
36,232,382 | prepar multicolour solid fluoresc carbon dot light emit diod use phenylethylamin co carbon agent carbon dot cds new type photoluminesc nanomateri attract extens attent various field uniqu luminesc properti howev cds exhibit fluoresc quench solid state aggreg state limit applic paper uniqu strategi propos regul solut achiev multicolour fluoresc cds solid state report success prepar orang green blue solid fluoresc cds use citric acid urea phenylethylamin precursor methanol ethanol water solvent respect solid state fluoresc cds may caus linkag phenylethyl structur surfac cds format effect dispers cds prevent interact graphit nuclei meanwhil multicolour solid fluoresc cds realiz adjust solvent prepar process base excel fluoresc properti cds orang green blue light emit diod led prepar white led wled obtain mix three colour solid fluoresc cds show applic potenti cds display light equip | D002244;D045663 | T121;T196;T073 |
36,232,381 | alter surfac express insulin degrad enzym monocyt lymphocyt covid patient diagnosi hospit discharg although covid diseas develop worldwid pandem pathophysiolog remain fulli understood insulin degrad enzym ide zinc metalloproteas high affin insulin found interactom multipl sar cov protein howev relev ide innat adapt immun respons elicit circul peripher blood mononuclear cell unknown show ide high express surfac circul monocyt cell cd cd lower extent b cell healthi control notabl ide surfac express upregul monocyt covid patient diagnosi increas sever patient howev ide surfac express downregul relat healthi control month hospit discharg studi immun subset effect pronounc male femal thus sex depend addit ide level monocyt cd cell cd cell invers correl circul insulin level covid patient diagnosi hospit discharg note high glucos insulin level downregul ide surfac express monocyt isol healthi donor without affect express cd cell cd cell conclus studi reveal sex metabol depend regul ide monocyt suggest regul might import recruit immun cell site infect well glucometabol control covid patient | D000086382;D007339 | T116;T047;T126;T067 |
36,232,380 | target maladapt effect bing drink circadian gene express previous studi support role circadian gene regul alcohol intak reveal harm alcohol use alter circadian rhythm howev minim knowledg effect chronic alcohol process rhythmic circadian gene express across brain region import circadian biolog alcohol intak therefor present studi sought test effect chronic bing like drink diurnal circadian gene express pattern master circadian pacemak scn ventral tegment area vta nucleus accumben nac high drink dark hdid mice uniqu genet risk model drink intox consist earlier find found week bing like drink reduc amplitud sever core circadian clock gene nac scn vta better inform use circadian relev pharmacotherapi reduc harm drink amelior alcohol effect circadian gene express test whether casein kinas inhibitor pf phosphodiesteras type upstream regul circadian signal inhibitor apremilast would reduc bing like intak mitig circadian gene suppress pf reduc intak circadian gene effect contrast apremilast reduc drink effect circadian express pattern | D063425 | T055 |
36,232,379 | poli butylen adipateterephthal co glycol copolyest synthesi base methyl glycol improv barrier properti synthesi structur properti main problem manufactur tradit biodegrad plastic expens manufactur polym deriv petroleum applic scope current limit due poor comprehens perform studi novel biodegrad poli butylen adip acidterephthal co glycol acid pbatga copolyest glycol acid unit success synthes esterif polycondens use cheap coal chemic byproduct methyl glycol instead expens glycol acid structur copolyest character atr ftir h nmr dsc xrd barrier properti water contact angl heat resist mechan properti test accord experi result pbatga copolyest show improv oxygen water vapor barrier charact better hydrophil compar pbat crystal peak pbatga elev c c content ga unit mol meanwhil elong break pbatga result indic pbatga copolyest good potenti high water vapor barrier degrad packag materi | D063566;D010578 | T109;T073 |
36,232,378 | automat segment laser induc injuri oct imag base deep neural network model optic coher tomographi oct consider applic potenti noninvas diagnosi diseas monitor skin diseas basal cell carcinoma bcc destruct henc quantit segment skin import earli diagnosi treatment deep neural network wide use boundari recognit segment diseas area medic imag research oct skin segment laser induc skin damag segment base deep neural network still infanc segment quantit analysi pipelin laser skin injuri skin stratif base deep neural network model propos base stratif mous skin laser injuri model mous skin induc laser construct multilay structur injuri area accur segment use deep neural network method first intact area mous skin damag area differ laser radiat dose collect oct system label manual label experienc histologist varieti deep neural network model use realiz segment skin layer damag area skin dataset particular u net model base dual attent mechan use realiz segment laser damag structur result compar analyz segment result show dice coeffici mous dermi layer injuri area reach dice coeffici fat layer muscl layer reach evalu result averag surfac distanc assd hausdorff distanc hd indic segment result excel high overlap rate manual label area short edg distanc result studi import applic valu quantit analysi laser induc skin injuri explor laser biolog effect potenti applic valu earli noninvas detect diseas monitor postop recoveri futur | D007091;D041623 | T060;T066 |
36,232,377 | role extracellular matrix inflamm abdomin aortic aneurysm abdomin aortic aneurysm aaa one danger cardiovascular diseas occur main men age year asymptomat patient diagnos late usual suffer pain abdomin caviti late detect aaa contribut high mortal rate mani environment genet molecular factor contribut develop subsequ ruptur aaa inflamm apoptosi smooth muscl cell degrad extracellular matrix aaa wall believ major molecular process under aaa format pharmacolog treatment implement prevent format aaa cure diseas therefor import patient diagnos earli stage diseas biomark contribut assess concentr level help determin level rate aaa develop potenti biomark today includ homocystein cathepsin osteopontin osteoprotegerin review describ major aspect molecular process take place aortic wall aaa format addit biomark monitor contribut prompt diagnosi aaa patient age year describ | D017544 | T047 |
36,232,376 | new insight pivot role amygdala inflamm relat depress anxieti disord depress anxieti disord two preval psychiatr diseas affect hundr million individu worldwid understand etiolog relat mechan great import might yield new therapeut strategi treat diseas effect past decad grow number studi point import stress induc inflammatori respons amygdala kernel region process emot stimuli potenti critic contributor pathophysiolog depress anxieti disord review first summar recent progress anim human studi toward understand causal link stress induc inflamm depress anxieti disord particular emphasi find show effect inflamm function chang neuron amygdala level rang molecular signal cellular function synapt plastic neural circuit behavior well contribut patholog inflamm relat depress anxieti disord final conclud discuss difficulti surround current research propos issu worth futur studi field | D000679;D003863 | T023;T184;T048 |
36,232,375 | nsd promis target hematolog disord alter epigenet machineri critic involv cancer develop mainten therefor protein charg generat epigenet modif activ studi potenti target anticanc therapi import widespread epigenet mark dimethyl histon lysin hkme recent consid mere intermedi toward generat trimethyl form recent data support specif role mani aspect genom regul hk dimethyl main carri protein nuclear set domain nsd famili among nsd one relev member key role normal hematopoiet develop consequ nsd frequent alter sever type tumor especi hematolog malign herein discuss role nsd patholog process review recent find develop new compound aim oncogen form novel anticanc candid | D006402;D009369 | T191;T047 |
36,232,374 | mdm base proteolysi target chimera protac innov drug strategi cancer treatment proteolysi target chimera protac molecul select degrad protein interest poi incorpor ligand recruit mous doubl minut mdm protac form call mdm base protac shown promis cancer treatment due dual mechan action protac recruit mdm prevent bind p result degrad poi also increas intracellular level p suppressor activ whole set biolog process cell cycl arrest apoptosi addit protac certain case allow degrad target nanomolar potenc rapid sustain manner time less suscept develop resist toler without caus chang protein express select target includ respect isoform mutat cell type overcom limit associ use inhibitor therapeut target therefor aim review analyz discuss characterist mdm base protac develop degrad oncogen protein understand potenti futur anticanc drug | D000970;D009369;D051736 | T116;T121;T191;T109;T123 |
36,232,373 | keratocyt differenti regul nf b tgf signal crosstalk interleukin il transform growth factor beta tgf import cytokin involv corneal wound heal studi effect cytokin corneal stromal cell keratocyt differenti il treatment result reduc keratocyt phenotyp evid morpholog chang decreas express keratocyt marker includ keratocan lumican aldha cd tgf treatment induc keratocyt differenti toward myofibroblast phenotyp inhibit simultan treatment il seen inhibit sma express morpholog chang reduc contract found mechan crosstalk il tgf occur via regul nf b signal pathway sinc il induc inhibit tgf stimul keratocyt myofibroblast differenti abolish specif nf b inhibitor tpca found smad particip downstream signal smad express level negat regul il posit regul tgf tpca treatment led overal upregul smad mrna protein level suggest nf b signal downregul smad express level keratocyt propos regul cell differenti keratocyt fibroblast eventu myofibroblast close relat oppos effect il tgf mechan govern crosstalk nf b signal | D016328;D016212 | T123;T116;T129 |
36,232,372 | alter central liver metabol pediatr patient non alcohol fatti liver diseas non alcohol fatti liver diseas nafld common chronic liver diseas children associ overweight insulin resist ir almost noth known vivo alter liver metabol nafld especi earli stage non alcohol steatohepat nash use complex mathemat model liver metabol quantifi central hepat metabol function children biopsi proven nafld patient person model variant generat base enzym abund determin mass spectroscopi analysi reveal statist signific alter hepat carbohydr lipid ammonia metabol increas degre obes sever nafld histolog featur nash ir display oppos associ chang carbohydr lipid metabol synergist decreas urea synthesi favor increas releas glutamin driver liver fibrosi taken togeth studi reveal alreadi signific alter nash liver pediatr patient howev differ modul simultan presenc ir | D007333;D065626 | T047;T046 |
36,232,371 | delay diagnosi congenit combin pituitari hormon defici includ sever growth hormon defici children persist neonat hypoglycemia case report review apart stimul human growth cell prolifer growth hormon gh pleiotrop metabol effect period life sever gh defici common compon combin pituitari hormon defici cphd cphd may caus mutat gene encod transcript factor signal molecul involv normal pituitari develop howev often genet caus remain unknown symptom depend hormon defici first symptom gh adrenocorticotrop hormon acth defici may persist hypoglycemia appar healthi newborn often neglect diagnos cphd base decreas concentr hormon secret anterior pituitari peripher endocrin gland find magnet reson imag vari wide includ anterior pituitari hypoplasiaaplasia pituitari stalk interrupt syndrom psis delay diagnosi treatment life threaten gh therapi necessari recov hypoglycemia improv auxolog psychomotor develop present two girl diagnos treat depart diagnosi cphd delay despit persist neonat hypoglycemia review similar case attent paid progress genet assess patient sinc introduct whole exom sequenc especi import psis | D005315;D019382;D007003;D007232;D010900 | T121;T047;T116;T125 |
36,232,370 | platelet sr psoxcxcl cxcr axi influenc thrombot propens prognosi coronari arteri diseas platelet express transmembran chemokin sr psoxcxcl proteolyt cleavag generat scxcl solubl chemokin scxcl engag cxcr platelet synergist propag degranul aggreg thrombot respons current investig pro thrombot prognost associ platelet cxcl cxcr axi cad n ccs n ac n patient platelet surfac associ cxcl cxcr surfac express ascertain flow cytometri correl signific platelet activ marker cdp denot degranul pac bind denot b integrin activ higher platelet cxcl surfac associ st quartil vs nd th quartil correspond signific elev collagen induc platelet aggreg assess whole blood imped aggregometri platelet cxcl cxcr express alter dyslipidemia triglycerid total cholesterol ldl level higher gt median plasma hdl level correspond decreas platelet cxcl cxcr although platelet cxcl cxcr express chang signific correl troponin level correspond higher creatin kinas ck activ progress deterior left ventricular eject fraction lvef admiss elev th quartil platelet cxcl p cxcr p measur admiss signific associ wors prognosi howev cox ph regress analysi platelet cxcl ascertain independ predictor caus mortal therefor platelet cxcl cxcr axi may influenc thrombot propens prognosi cad patient | D001792;D019743;D003324 | T025;T116;T047;T129 |
36,232,369 | analysi tumor infiltr cell transcriptom reveal uniqu genet signatur across differ type cancer cd cd cell play key role cellular immun respons cancer cytotox respons effector lineag differenti respect subset found differ type cancer howev unclear whether tumor infiltr cell subset exhibit similar transcriptom profil across differ type cancer comparison healthi tissu resid cell thus analyz singl cell transcriptom five tumor infiltr cd cd treg cell obtain differ type cancer identifi specif pathway subset malign environ silico analysi perform singl cell rna sequenc data avail public repositori gene express omnibus includ breast cancer melanoma colorect cancer lung cancer head neck cancer dimension reduct cluster select differ subpopul malign nonmalign dataset common gene across differ type cancer identifi compar nonmalign gene cell subset identifi specif pathway exclus pathway cd cell cd cell treg common pathway tumor infiltr cell subset identifi final identifi pathway compar rnaseq proteom data obtain cell subset cultur malign environ observ cytokin signal especi th type cytokin top overrepres pathway treg malign sampl | D008545;D059467 | T191;T081;T086 |
36,232,368 | clinic trial new drug vascular cognit impair vascular dementia popul age challeng treatment cognit impair dementia vascular dementia second lead caus dementia alzheim diseas cognit consequ ischem brain injuri recogn prefer target therapeut strategi prompt search potenti agent keyword vascular dementia use search clinicaltrialsgov determin agent repres phase ii iii iv agent classifi basi mechan random control trial meet inclus criteria complet past year ongo plan stage also identifi one trial phase nine phase ii six phase iii one phase iv fewer trial new drug improv cognit amelior behavior psycholog symptom dementia target vascular dementia alzheim dementia drug trial vascular dementia overlap drug trial target function outcom cerebrovascular diseas intern pharmaceut compani invest new drug target vci vascular dementia remain insuffici | D000544;D003072;D060825;D015140 | T047;T048 |
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