PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,232,567 | efficaci safeti ginger side effect chemotherapi breast cancer patient systemat review meta analysi cancer one lead caus death world breast cancer preval cancer chemotherapi induc nausea vomit cinv one serious side effect chemotherapi current cinv treatment option sever flaw altern treatment option requir ginger tradit use treat nausea vomit also anticanc properti breast cancer cell base find research investig whether use ginger treat cinv breast cancer patient effect safe search pubm embas cochran librari cnki wanfang incept june outcom includ rhode index score nausea vomit retch sever frequenc cinv five rcts includ pool includ data perform subgroup analysi type cinv overal author found ginger associ reduct cinv subgroup sensit analysi reveal manag sever acut cinv breast cancer patient ginger effici term manag delay cinv breast cancer patient ginger also statist signific author conclud ginger may help lower acut delay cinv breast cancer patient sinc serious side effect ginger thought safe | D000932;D000970;D001943;D064420;D020939 | T046;T037;T002;T121;T191;T109;T039 |
36,232,566 | interpret machin learn model molecular design tyrosin kinas inhibitor use variat autoencod perturb base approach chemic space explor current studi introduc integr machin learn strategi autonom molecular design protein kinas inhibitor use variat autoencod novel cluster base perturb approach explor chemic latent space propos strategi combin autoencod base embed small molecul cluster base perturb approach effici navig latent space featur base kinas inhibit likelihood classifi guid optim molecular properti target molecular design propos generat approach molecul share similar structur tend cluster latent space interpol two molecul latent space enabl smooth chang molecular structur properti result demonstr propos strategi effici explor latent space small molecul kinas inhibitor along interpret direct guid generat novel famili specif kinas molecul display signific scaffold divers optim biochem properti assess latent base chemic featur base binari multiclass classifi develop robust probabilist evalu kinas inhibit likelihood specif tailor guid molecular design novel src kinas molecul generat molecul origin lck abl kinas inhibitor yield novel valid src kinas compound high kinas inhibit likelihood probabl valu p gt high similar tanimoto coeffici gt known src inhibitor combin molecular perturb design kinas inhibit likelihood analysi similar assess show propos molecular design strategi produc novel valid molecul transform known inhibitor differ kinas famili potenti chemic probe src kinas excel physicochem profil high similar known src kinas drug result studi suggest task specif manipul bias latent space may import direct effect task orient target specif autonom chemic design model | D000069550;D013026 | T057;T066 |
36,232,565 | polo like kinas play essenti role cytoprotect mg induc proteasom inhibit via phosphoryl serin hspb protein homeostasi includ protein fold refold degrad thought declin age hspb also known b crystallin prevent target protein aggreg molecular chaperon exhibit cytoprotect function various cell stress elucid effect hspb endoplasm reticulum er stress search novel bind protein hspb use proxim depend biotin label method protein presum interact hspb cell treat proteasom inhibitor mg identifi revers biotin bind capac method combin tamavidin rev magnet bead mass spectrometri discov new bind protein hspb polo like kinas plk apoptosi relat enzym express plk upregul mg treatment co local hspb near er l muscl cell inhibit plk decreas er stress induc phosphoryl serin hspb increas apoptosi activ caspas er stress overexpress hspb wt suppress er stress induc caspas activ observ phospho defici hspb mutant result clarifi role hspb phosphoryl er stress suggest plkhspb pathway play essenti role cytoprotect proteasom inhibit induc er stress | D046988;D061988 | T121;T126;T116 |
36,232,564 | germlin variant cancer relat gene among chines breast cancer patient next generat sequenc clinic base observ studi breast cancer bc associ hereditari compon deleteri germlin variant regard effect therapeut target conduct clinic base observ studi better understand distribut deleteri germlin variant assess clinicopatholog predictor relat variant among chines bc patient use cancer relat gene next generat sequenc panel novemb februari total bc patient recruit carri deleteri germlin variant cancer relat gene includ brca brca palb nbn mrea tp gene novel variant detect brca brca non brca gene variant panel gene hrr homolog recombin repair relat gene brca signific associ follow clinicopatholog factor age initi diagnosi bc famili histori cancer molecular subtyp ki index hereditari risk conclus expand spectrum germlin deleteri variant chines bc patient clinicopatholog predictor variant identifi facilit clinic genet test counsel appropri individu | D001943 | T191 |
36,232,563 | glucogallin attenu lps induc signal macrophag protect mice sepsi anti oxid anti inflammatori effect beta glucogallin bgg plant deriv natur product evalu vitro vivo studi vitro studi abil bgg pre treatment quench lps induc effect compar lps alon macrophag investig found bgg pre treatment show signific decreas ros superoxid pro inflammatori cytokin tnf alpha il il il il increas reduc glutathion coupl restor mitochondri membran potenti gene profil valid qpcr show bgg pre treatment downregul lps induc express c fos fas mmp ino cox myd trif traf tram c jun nf b observ bgg pre treatment reduc nuclear transloc lps activ nf b thus reduc subsequ express nlrp il indic abil bgg inhibit inflammasom format molecular dock studi show bgg could bind activ site tlr final lps driven sepsi mous model show pre treatment bgg sustain toxic shock evid surviv studi clear show therapeut potenti bgg toxic shock syndrom | D001688;D018805 | T121;T047;T046;T123 |
36,232,562 | brassinosteroid signal downstream suppressor bin interact slfrigida like induc earli flower tomato brassinosteroid br signal import plant development process various compon interact form signal cascad compon wide studi arabidopsi howev littl inform avail tomato brassinosteroid insensit bin downstream suppressor br signal play critic role br signal pathway frigida key suppressor flower locus c overexpress could caus earli flower howev br signal regul frigida homolog protein adjust flower time still unknown studi identifi frigida like protein conserv frigida domain tomato yeast two hybrid bifc confirm slbin interact slfrls sub cellular local nucleus tissu specif express slfrls observ high young root flower biolog result reveal slfrls interact slbin regul earli flower mrna level slbin also increas slfrl overexpress line relat express slcpd increas upon slfrl silenc sldwf slbin decreas import br signal research first provid molecular evid brs regul tomato flower interact slfrls slbin studi promot understand specif pathway essenti floral regul | D017360;D029681;D018551 | T168;T116;T002 |
36,232,561 | nanoparticl load platinum drug colorect cancer therapi colorect cancer common cancer men women numer studi therapeut effect nanoparticl colorect cancer report platinum treatment well medic compris nanoparticl util drug resist restrict use platinum medicin despit consider efficaci varieti cancer review report clinic licens platinum medicin cisplatin carboplatin oxaliplatin combin various nanoparticl evalu therapeut efficaci treatment colorect cancer includ mechan action resist limit | D000970;D015179;D053758 | T121;T109;T073;T191 |
36,232,560 | elev sustain intracellular calcium signal necessari efficaci induct human sperm acrosom reaction progesteron prostaglandin e postul trigger human sperm acrosom reaction ar howev report efficaci variabl like part reflect plethora experiment condit methodolog use detect physiolog relev event purpos studi develop assay robust induct object measur complet ar sperm healthi volunt patient undertak ivf treat varieti ligand progesteron prostaglandin e nh cl alon combin ar motil intracellular calcium measur measur use flow cytometri comput assist sperm analysi casa fluorimetri respect ar signific increas simultan applic progesteron prostaglandin e nh cl follow elev sustain intracellular calcium concentr howev observ notabl inter intra donor sampl heterogen ar induct studi patient sampl found relationship ivf fertil rate ar conclud progesteron prostaglandin e alon signific increas percentag live acrosom react sperm assay util drug discoveri sperm toxicolog studi predict ivf success | D020101;D002118 | T121;T043;T123;T196 |
36,232,559 | genom landscap mix phenotyp acut leukemia mix phenotyp leukemia mpal type acut leukemia blast popul show mix featur myeloid lymphoid andor b lymphoid differenti mpal rare carri poor prognosi thus often pose diagnost therapeut challeng convent diagnosi mpal requir either singl blast popul lineag defin phenotyp express multipl lineag myeloid b cell andor cell biphenotyp two distinct blast popul independ satisfi criteria design aml b andor bilineag given rariti mpal minim studi perform describ genom landscap neoplasm irb approv obtain central mcc databas search patient diagnosi acut undifferenti leukemia aul acut leukemia ambigu lineag alal mpal patient diagnos manual review hematopathologist confirm diagnosi mpal genom molecular data collat emr bioinformat mcc genom repositori twenti eight patient mpal identifi thirteen femal male averag age year old rang ten case biclon biphenotyp diagnos follow bmyeloid n tmyeloid n tb n cytogenet analysi karyotyp fish avail patient frequent recurr abnorm complex karyotyp n bcrabl transloc n del q n polysomi n mutat analysi avail patient wherein mutat detect uniqu gene frequent mutat gene tp runx wt mll flt cbl asxl tet mapk mll mapk target potenti target biomark found case overal surviv month rang ten patient treat allogen stem cell transplant superior outcom p one largest seri mpal case date corrobor previous find enrich detect runx flt itd mutat along discoveri unreport mutat mapk may amen therapeut manipul also report frequent occurr aml mds relat chang aml mrc defin cytogenet abnorm final show patient receiv stem cell transplant better overal surviv find support need genom profil mpal case exploit opportun target therapi orphan diseas dismal prognosi | D015470;D054198 | T191 |
36,232,558 | glcnacyl renal patho physiolog kidney maintain intern milieu homeostasi well regul manipul bodi fluid composit task perform correl structur function nephron kidney diseas chronic condit impact healthcar program global despit effort therapeut option treatment limit develop chronic degen diseas associ chang protein glcnacyl post translat modif involv regul divers cell function glcnacyl regul enzymat balanc glcnac transferas ogt glcnacas oga add remov glcnac residu target protein respect furthermor hexosamin biosynthet pathway provid substrat protein glcnacyl beyond physiolog role sever report indic particip protein glcnacyl cardiovascular neurodegen metabol diseas review discuss impact protein glcnacyl physiolog renal function diseas condit possibl futur direct field | D000117;D017351 | T121;T109;T126;T116 |
36,232,557 | character novel myrosinas high activ marin bacterium shewanella baltica myr myrosinas hydrolyz glucosinol generat isothiocyan cancer prevent anti cancer properti main sourc myrosinas crucifer plant improv effici isothiocyan prepar necessari explor novel sourc myrosinas studi describ bacterium shewanella baltica myr isol marin mud capabl produc novel myrosinas smyr molecular weight kda crude enzym smyr show highest activ c ph sinigrin glucoraphanin hydrolyz activ smyr umg respect moreov reaction temperatur c ph crude enzym smyr could effici degrad glucoraphanin sulforaphan within min yield mgml correspond convers effici sulforaphan glucoraphanin summari baltica myr myrosinas smyr novel myrosinas use prepar isothiocyan | D001937;D020592 | T007;T168;T002 |
36,232,556 | phosphor base bi function flame retard base phosphaphenanthren aluminum hypophosphit epoxi thermoset phosphor base bi function compound hpdal use reactiv type flame retard fr epoxi thermoset ep aim improv flame retard effici phosphorus base compound hpdal consist two differ p group aluminum phosphin ahp phosphophenanthren dopo differ phosphor chemic environ thus exert differ fr action exhibit intramolecular p p group synergi possess superior flame retard effici compar dopo ahp alon physic combin dopoahp ep ad wt hpdal made ep composit acquir loi valu pass ul v rate blow effect exhibit decreas heatsmok releas flame retard mode action hpdal confirm experi scan electron microscop sem x ray photoelectron spectroscopi xps thermogravimetri fourier transform infrar spectroscopi gas chromatographmass spectromet tg ftir gcms result indic phosphor base frs show differ influenc flame retard composit main depend chemic structur hpdal flame inhibit effect gas phase char effect condens phase well balanc distribut p content gascondens phase furthermor addit hpdal hard impair mechan properti matrix due link chemic bond | D005411 | T120 |
36,232,555 | modul aryl hydrocarbon receptor express allevi neuropath pain chronic constrict nerv injuri anim model neuropath pain well known occur damag somatosensori system aryl hydrocarbon receptor ahr neuroprotect effect central nervous system subject intern extern stimul howev exact mechan ahr regul neuropath pain poor understood nerv explant cultur chronic constrict nerv injuri cci model wild ahr knockout mice use studi nerv explant cultur ovoid number increas ahr condit decreas omeprazol ahr agonist dose depend manner increas nerv degener associ inflamm respons appear ahr condit chang attenu omeprazol high express ahr injur nerv note cci delet ahr aggrav nerv damag restor omeprazol delet ahr increas ngf express reduc axon number paw skin attenu omeprazol high express inflamm reaction dorsal spinal cord somatosensori cortex hippocampus note ahr delet anim administr omeprazol attenu inflammatori respons also amplitud somatosensori evok potenti delet ahr aggrav neurobehavior compar wild type behavior attenu omeprazol chronic constrict nerv injuri augment ahr express injur nerv ahr delet worsen damag ahr agonist omeprazol counteract chang ahr agonist could potenti candid neuropath pain treatment | D000071576;D009437;D018696;D020196 | T047;T037;T121;T169;T184 |
36,232,554 | antagonist growth hormon releas hormon potenti antitumor effect pemetrex cisplatin pleural mesothelioma pleural mesothelioma pm aggress cancer poor prognosi effect therapi main caus exposur asbesto antagonist growth hormon releas hormon ghrh display strong antitumor effect mani experiment cancer includ lung cancer mesothelioma aim determin whether ghrh antagonist mia potenti antitumor effect cisplatin pemetrex pm vitro mia combin cisplatin pemetrex synergist reduc cell viabil restrain cell prolifer enhanc apoptosi compar drug alon vivo combin result strong growth inhibit msto h xenograft decreas tumor cell prolifer increas apoptosi mechanist mia particular chemotherapeut drug inhibit prolif oncogen pathway mapk erk cmyc downregul cyclin b mrnas inflammatori pathway nf kb stat also reduc well oxid angiogen tumorigen marker ino cox mmp mmp hmgb growth factor vegf igf overal find strong suggest ghrh antagonist mia class mia could increas efficaci standard therapi pm | D024243;D008654;D000086002;D010997 | T191;T123;T116 |
36,232,553 | antivir drug screen swine acut diarrhea syndrom coronavirus coronavirus possibl cross speci virus caus sever epidem ongo emerg coronavirus diseas covid caus sar cov pose sever threat global economi public health generat great concern zoonot virus swine acut diarrhea syndrom coronavirus sad cov alpha coronavirus respons mass piglet death result unpreced econom loss approv drug vaccin current avail sad cov infect given potenti abil caus cross speci infect essenti develop specif antivir drug vaccin sad cov drug screen perform total compound contain drug librari strategi exist medic repurpos identifi five compound gemcitabin mycophenol mofetil mycophenol acid methylen blue cepharanthin exhibit inhibitori effect sad cov dose depend manner cepharanthin methylen blue confirm block viral entri gemcitabin mycophenol mofetil mycophenol acid methylen blue could inhibit viral replic sad cov entri first report sad cov drug screen found five compound drug librari potenti anti sad cov drug support develop antivir drug possibl outbreak sad cov futur | D000998;D000086382 | T121;T047;T067 |
36,232,552 | imag infect cycl singl virion level phage e coli infect virus find invad target high specif effici exact molecular mechan infect cycl yet unclear infect involv mechan event singl particl method employ allevi problem ensembl averag use tirf microscopi uncov spatial dynam target recognit bind individu phage particl initi phase virion bound revers bacteri membran via two dimension diffus explor stabl bacteriophag anchor achiev tail fiber complex receptor bind could observ detail atom forc microscopi afm aqueous buffer condit six anchor fiber given phage display isotrop spatial orient viral infect led onset irrevers structur program host occur three distinct step first bacteri cell surfac rough monitor afm increas progress second membran bleb form minut time scale averag min observ phase contrast microscopi final host cell lyse violent explos process follow quick releas dispers phage progeni dna eject could evok vitro phototherm excit reveal genom releas mechan control prevent prematur deliveri host lysi gene singl particl approach employ thus provid unpreced insight detail complet viral cycl | D001435;D004926 | T007;T005 |
36,232,551 | renal corin essenti normal blood pressur sodium homeostasi atrial natriuret peptid anp mediat natriuresi known cardiac endocrin function sodium bodi fluid homeostasi corin proteas essenti anp activ studi role renal corin regul salt excret blood pressur creat corin condit knockout cko corin gene select disrupt kidney kcko heart hcko examin blood pressur urinari na cl excret cardiac hypertrophi wild type corin global ko kcko hcko mice fed normal high salt diet found normal salt diet nacl corin kcko hcko mice increas blood pressur indic renal cardiac corin necessari normal blood pressur mice high salt diet nacl reduc urinari na cl excret increas bodi weight salt exacerb hypertens cardiac hypertrophi observ corin kcko mice contrast impair urinari na cl excret salt exacerb hypertens observ corin hcko mice result indic renal corin function import enhanc natriuresi upon high salt intak function compens cardiac corin function mice | D009320;D006973 | T047;T123;T116 |
36,232,550 | novel long act oxytocin analog increas efficaci reduc food intak bodi weight oxytocin oxt analogu design overcom limit short half life nativ oxt peptid test ask obes relat outcom diet induc obes dio spragu dawley rat vitro function assay conduct effect daili subcutan inject ask vs oxt pair feed assess food intak bodi weight vivo ask longer last oxt analog improv pharmacokinet compar oxt vs h chronic day administr ask administ nmolkg oxt dose titrat nmolkg oxt appear less effect reduc energi intak relat ask equimolar dose day vehicl treat anim gain bodi weight oxt rat maintain bodi weight treat ask declin weight continu day period lead reduct mean standard error compar baselin compar pair fed counterpart ask treat rat show pronounc reduct bodi weight studi summari ask promis oxt base therapeut extend vivo stabil improv potenc lead profound reduct bodi weight part explain reduc food intak | D004435;D010121 | T116;T038;T121;T040;T125;T033 |
36,232,549 | updat extracellular vesicl base vaccin therapeut combat covid covid pandem deep impact peopl worldwid sinc late sar cov first identifi wuhan china addit effect public health affect human various aspect life includ social econom cultur polit also true research made vigor effort overcom covid throughout world still long way go accord innumer therapeut vaccin candid studi efficaci tri clinic short span time exampl versatil extracellular vesicl membran bound particl releas type cell recent highlight term effect biocompat safeti fight covid thus tri explain use extracellular vesicl therapeut develop vaccin covid along mechan comprehens background applic trap coronavirus control cytokin storm also discuss obstacl clinic use extracellular vesicl could resolv futur | D000086382;D000067128;D014765 | T047;T026;T121;T129;T067 |
36,232,548 | microbiota gut brain axi psychiatr disord modul gut microbiom influenc human health subject intens research gut microbiota could associ gastroenterolog diseas also psychiatr disord import factor stress mode deliveri role probiot circadian clock system diet occup environment exposur relationship gut microbiota brain function bidirect communic describ microbiom gut brain axi especi underlin review discuss link intestin microbiom brain host respons involv differ pathway intestin microbiota nervous system eg neurotransmitt endocrin system immunolog mechan bacteri metabolit review microbiota alter result develop psychiatr disord includ major depress disord mdd schizophrenia scz bipolar disord bd autism spectrum disord asd attent deficit hyperact disord adhd | D000067877;D003865;D000069196;D064307 | T007;T028;T001;T048;T032 |
36,232,547 | pharmacokinet myo inositol wistar rat anim model myo inositol popular inositol live organ present sugar alcohol free form also describ lipid aim studi check concentr chang myo inositol solut time oral administr h period wistar type rat rat receiv gkg inositol solut distil water oral gavag estim paramet base serum concentr myo inositol observ nine individu rat regard time observ describ one compart pharmacokinet model first order absorpt zero order endogen input check inositol highest myo inositol concentr observ first hour oral administr serum test rat concentr began decreas immedi maxim peak inositol concentr continu decreas h level still higher administr plasma profil myo inositol concentr show rapid declin time possibl due metabol compound | D007294;D008055 | T121;T109;T127 |
36,232,546 | drosophila model organ studi basic mechan longev spatio tempor regul gene express determin fate function various cell tissu consequ correct develop function complex organ certain mechan gene activ regul provid adequ cell respons chang environment factor asid gene express disord lead various patholog alter express particular gene shown signific decreas increas lifespan wide rang organ yeast human drosophila fruit fli ideal model system explor mechan longev age due low cost easi handl mainten larg number progeni per adult short life cycl lifespan relat low number paralog gene high evolutionari conserv epigenet mechan signal pathway avail wide rang tool modul gene express vivo focus organ evolutionarili conserv signal pathway whose compon signific influenc age process interconnect pathway gene express regul | D029721;D008136 | T102;T123;T116;T079 |
36,232,545 | structur studi divers betacyanin class matur pigment rich fruit basella alba l basella alba l var rubra malabar spinach identif betacyanin basella alba l basella alba l var rubra fruit perform low high resolut mass spectrometri lrms hrms well h c two dimension nmr reveal hitherto complet known betacyanin class plant kingdom especi presenc uniqu nitrogen acyl moieti structur pigment ascertain hrms orbitrap detect except detect polar betacyanin glycosyl deriv presenc seri previous report pigment malonyl betanidin glusosid acyl migrat isom along evid hydroxi butyryl betacyanin report first complet nmr data obtain novel princip acyl gomphrenin hydroxycinnam acid e caffeoyl gomphrenin malabarin e sinapoyl gomphrenin gandolin e coumaroyl gomphrenin globosin e feruloyl gomphrenin basellin | D050859;D000073559 | T109;T002 |
36,232,544 | plasma proteom enabl differenti lung adenocarcinoma chronic obstruct pulmonari diseas copd chronic obstruct pulmonari diseas copd major risk factor develop lung adenocarcinoma ac ac often develop under copd thus differenti entiti biomark challeng although surviv ac patient strong depend earli diagnosi biomark panel ac detect differenti copd still miss plasma sampl patient ac without under copd copd patient hospit control analyz use mass spectrometri base proteom perform univari statist addit evalu machin learn algorithm regard differenti ac vs copd ac copd vs copd univari statist reveal signific regul protein signific regul patient group furthermor random forest classif yield best perform differenti ac vs copd area curv auc ac copd vs copd auc influenti protein identifi permut featur import compar identifi univari test demonstr great potenti machin learn differenti high similar diseas entiti present panel biomark candid consid develop futur biomark panel | D000077192;D008175;D029424 | T191;T047 |
36,232,543 | effect drought host growth santalum album seedl pot cultur santalum album semi parasit plant growth often restrict due lack host water plantat establish studi effect water host growth album seedl studi pot cultur result show net photosynthet rate height album seedl decreas signific drought stress compar seedl album grown without host host could signific increas growth album seedl content solubl sugar prolin album leav increas signific drought stress drought stress result signific accumul malondialdehyd increment antioxid enzym activ non enzymat antioxid substanc antioxid capac stronger malondialdehyd content lower seedl leav album host seedl without host rna seq use analyz transcript express profil album leav result consist physiolog data result indic host promot seedl growth album increas antioxid capac osmot adjust substanc content seedl album allevi damag caus drought | D032123;D036226 | T168;T002 |
36,232,542 | identif molecular character diverg asian like canin parvovirus type b cpv b strain southern itali canin parvovirus type cpv infecti agent relev domest wild carnivoran recent studi document introduct spread cpv c strain asian origin italian canin popul investig tissu sampl puppi collect necropsi presenc viral enteropathogen sampl test posit cpv full code sequenc cpv b vp asp strain obtain virus relat cpv c strain asian origin unrel european cpv b strain sequenc genet signatur typic asian strain ns val val pro vp gli tyr ile mutat rare report asian cpv b strain ns n vp arg phylogenet analys place strain well support clade includ asian cpv c like strain alway basal singl sequenc long branch recombin observ strain specul could origin asian cpv c like strain acquir asp mutat studi report first evid asian like cpv b strain itali confirm occurr continu chang global cpv spread sinc posit converg mutat complic data interpret combin phylogenet mutat pattern analys crucial studi origin evolut cpv strain | D004283;D010322;D017993 | T047;T005 |
36,232,541 | effect seven day exposur silver nanoparticl fertil homeostasi zebrafish danio rerio silver nanoparticl agnp found open water effect low concentr organ homeostasi fulli understood aim studi determin short term exposur effect agnp coat pvp polyvinylpyrrolidon homeostasi liver gonad zebrafish sexual matur zebrafish expos seven day silver ion mgdm agnp mgdm last day liver test ovari subject histolog analysi liver analyz express cat gpxa gsr sod cypa gene last day experi lowest surviv rate found agnp mgdm group histolog analysi show agnp silver ion caus increas area hepatocyt highest prolifer index hepatocyt found agnp mgdm group furthermor agnp found interfer spermatogenesi oogonesi well reduc express level cat gpxa sod gene liver compar control group base result conclud exposur agnp caus cytotox chang zebrafish activ immun system negat affect process meiosi gonad generat oxid stress | D053768;D012834 | T196;T073 |
36,232,540 | compound heterozygosi aadc defici complex phenotyp term aadc protein popul aromat amino acid decarboxylas aadc defici rare monogen diseas due mutat ddc gene produc aadc homodimer pyridox phosphat depend enzym disord often fatal first decad character profound motor impair development delay last two year net rise number patient variant identifi mayb also push ongo gene therapi trial major identifi genotyp compound heterozyg effort underway reach earli diagnosi find possibl new markersnew fast method predict clinic outcom howev clear correl genotyp phenotyp exist date nevertheless homozyg patient reliabl result obtain use genet method combin avail comput tool crystal structur corrobor biochem investig recombin homodimer aadc variant obtain character solut variant molecular basi defect suggest valid sinc correl quit well mildnesssever homozyg phenotyp instead predict compound heterozyg patient difficult sinc complement effect could happen analyz exist literatur compound heterozygos aadc defici genet disord highlight order assess pathogen measur activ aadc heterodimer variant integr bioinformat structur function data whole protein constel theoret present patient wider discuss symptomat heterozygos aadc defici also present | D002262 | T126;T116 |
36,232,539 | increas nmur express mast cell synovi membran obes osteoarthr patient obes risk factor knee osteoarthr koa neuromedin u nmu nmu receptor nmur nmur associ obes relat disord found mast cell mcs elev osteoarthr howev nmunmur express examin synovi membran sm synovi mcs obes osteoarthr patient compar express nmu nmur nmur mast cell mc marker cpa sm koa patient categor normal weight nw bmi lt kgm n overweight ow bmi lt kgm n obes ob kgm n studi nmu nmur express mcs compar mc rich fraction mc rf cd mc rf cd mc rf extract use magnet isol mc poor fraction mc pf nmu nmur express compar nmur signific elev ow ob compar nw moreov cpa level signific greater ob nw nmur cpa express signific higher cd cd mc rf mc pf therefor nmur express elev sm ob koa patient express found mcs investig analyz nmunmur pathway mc may provid link obes koa patholog | D008407;D010003 | T025;T047 |
36,232,538 | italian precis medicin pediatr oncolog move beyond action alter neuroblastoma nb common extracrani solid tumor encount childhood although signific improv outcom patient high risk diseas prognosi patient metastat relaps refractori diseas poor henc clinic integr genom sequenc standard clinic practic necessari order develop person therapi children relaps refractori diseas personalizedmedicin preme project focus design innov therapeut strategi patient suffer relaps nb perform whole exom sequenc wes patient match tumor normal sampl identifi genet variant amen precis medicin specif two patient studi first case three year old male earli relaps nb second case year old male relaps year first diagnosi nb result review multi disciplinari molecular tumor board mtb clinic report issu order physician wes reveal mutat cgc cula gene case mutat cag psmc gene case patient treat accord action alter promis result effect treatment nb one main challeng pediatr oncolog era precis medicin need design new therapeut strategi nb fundament result demonstr feasibl incorpor clinic wes pediatr oncolog practic | D009447;D057285 | T191;T061;T091 |
36,232,537 | compar experiment investig biodegrad antimicrobi polym base composit produc print technolog enrich metal particl due prevail exist covid pandem novel practic strategi combat pathogen rise worldwid estim global around hospit patient acquir least one healthcar associ infect one novel strategi develop incorpor metal particl polymer materi neutral infecti agent consid broad spectrum antimicrobi potenc materi incorpor metal particl intend hybrid composit materi could inher add signific valu final product therefor research aim investig antimicrobi polymer pla base composit materi enhanc differ microparticl copper aluminum stainless steel bronz antimicrobi properti hybrid composit prepar composit materi sampl produc fuse filament fabric fff print technolog test differ time interv establish antimicrobi activ result present depict sampl prepar copper pla show best antibacteri activ min differ type bacteria compar sampl metal enrich pla base antibacteri sheet remark effect staphylococcus aureus escherichia coli therefor good candid futur biomed food packag tissu engin prosthet materi textil industri scienc technolog applic thus antimicrobi sheet made pla mix metal particl offer sustain solut wide rang applic touch surfac big concern | D000890;D000086382 | T121;T047;T067 |
36,232,536 | clinic signific claudin express oral squamous cell carcinoma chang claudin express demonstr various tumor present studi specif compar claudin express oral squamous cell carcinoma oscc healthi oral epithelium individu analyz associ claudin express clinic relev cours paramet studi includ tissu sampl clinic relev follow data patient primari untreat oscc oral mucosa analyz via western blot express claudin import tumor healthi tissu obtain pairwis patient allow intraindividu comparison healthi tumor epithelium oral caviti express claudin protein intraindividu comparison reveal oscc claudin express higher express claudin lower healthi epithelium associ found increas claudin express shorter relaps free surviv addit reduc express claudin negat impact relaps free surviv furthermor associ reduc express claudin stage tumor presenc lymph node metastas found thus express level claudin appear predict diagnosi prognosi oscc | D002294;D006258;D009062 | T191 |
36,232,535 | hormet spatiotempor photosystem ii respons mechan salvia excess zinc exposur exposur salvia sclarea plant excess zn day result increas ca fe mn zn concentr decreas mg aboveground tissu signific increas aboveground tissu mn vital oxygen evolv complex oec photosystem ii psii contribut higher effici oec togeth increas fe fundament role compon enzym involv electron transport process result increas electron transport rate etr decreas mg content aboveground tissu contribut decreas chlorophyl content reduc excess absorpt sunlight oper improv psii photochemistri psii decreas excess energi psii lower degre photoinhibit judg increas maximum effici psii photochemistri f v f molecular mechan zn treat leav display improv psii photochemistri increas fraction open psii reaction center q p main increas effici reaction center f v f enhanc etr element bioimag zn ca laser ablat induct coupl plasma mass spectrometri la icp ms reveal co local mid leaf vein high zn concentr locat mid leaf vein area mesophyl cell accumul small amount zn thus resembl spatiotempor heterogen respons suggest adapt strategi find contribut understand exposur excess zn trigger hormet respons psii photochemistri exposur aromat medicin plant excess zn hydropon regard econom approach amelior defici fe zn essenti micronutri human health | D045332;D027544 | T116;T002;T026;T126;T123 |
36,232,534 | phytochem chemoprevent activ obtain thai medicin plant mammea siamensi miq ander isol structur determin new prenylcoumarin inhibitori activ aromatas aim search phytochem aromatas inhibitori activ five new prenylcoumarin mammeasin k l n isol methanol extract mammea siamensi miq ander flower fam calophyllacea origin thailand stereostructur elucid base spectroscop properti among new compound ic possess relat strong inhibitori activ aromatas target drug alreadi use clinic practic treatment prevent estrogen depend breast cancer analysi lineweav burk plot show competit inhibit aromatas k addit potent coumarin constitu mammea bab cyclo k competit inhibitori activ equival aminoglutethimid aromatas inhibitor use therapeut | D031252;D010946 | T002 |
36,232,533 | novel morpholin bear quinolin deriv potenti cholinesteras inhibitor influenc amin carbon linker phenylamino group seri novel n phenylaminoquinolin deriv contain morpholin group design synthes anti cholinesteras activ abt radic scaveng activ test among compound g h j l compar inhibit activ refer galantamin ach especi compound g reveal potent inhibit ach bche ic valu respect kinet analysi demonstr compound g act mix type ach inhibitor dock comparison ach complex agre differ inhibitori potenc observ experi besid compound f l show excel abt radic scaveng activ ic valu respect superior control trolox ic worth note aminoquinolin deriv exhibit better drug like properti | D000544;D006912 | T121;T047;T109;T048 |
36,232,532 | landscap cellular bioeffect trigger ultrasound induc sonopor sonopor process transient pore format cell membran trigger ultrasound us numer studi provid us firm evid sonopor may assist cancer treatment effect drug gene deliveri howev massiv gap bodi literatur issu understand complex biophys biochem sonopor induc cellular effect studi provid detail explan us trigger bioeffect particular cell compart intern environ cell well consequ cell reproduct growth moreov detail biophys insight us provok pore format present studi expect review knowledg cellular effect initi us induc sonopor summar attempt clinic implement | D045423;D013010 | T074;T062 |
36,232,531 | polyanilin deriv nitrogen contain carbon nanostructur differ morpholog anod modifi microbi fuel cell anod modif carbon nanomateri import strategi improv microbi fuel cell mfc perform presenc nitrogen carbon network introduc activ nitrogen function group consid benefici anod modif aim nitrogen contain carbon nanostructur ncns differ morpholog obtain via carbon polyanilin investig anod modifi mfcs present studi investig influenc ncn morpholog chang anod microbi communiti mfc perform result show nanofibrillar morpholog ncns benefici improv mfc perform maximum power densiti mwm time higher anod modifi carbon polyanilin granular morpholog time higher mfc use carbon cloth anod nanofibrillar morpholog due well defin individu nanofib separ microgap micropor better organ carbon network lead larger specif surfac area higher conduct allow effici substrat transport better bacteri colon greater relat abund geobact thermoanaerobact justifi improv mfc perform | D001674;D049329 | T074;T073 |
36,232,530 | ectop express arabidopsi thaliana zdof tomato solanum lycopersicum l associ improv greenhous product enhanc carbon nitrogen use larg collect transgen tomato line ectop express differ arabidopsi thaliana transcript factor screen variant alter leaf starch line may affect carbon partit alloc sink focus l harbor thaliana zdof dna bind one zinc finger isoform atzdof gene fold higher starch sucros ratio sourc leav diel p lt aim determin whether associ effect product l plant alter nitrogen n carbon c metabol n c ratio higher six week old l treat n l growth less inhibit compar wild type accompani faster root elong p lt six week old l acquir dri matter ppm co compar ambient co p lt wild type wt remain unchang gc ms tof data show l sourc leav enrich amino acid compar wt dpa fruit greater mass higher sucros increas yield p lt compar wt affymetrix cdna array analysi suggest cdnas alter fold p lt l sourc leav c label fruit disk identifi potenti differ dpa fruit metabol suggest post transcript regul import conclud atzdof germplasm deriv therefrom investig climat chang adapt potenti | D017360;D018551 | T168;T002 |
36,232,529 | sequenc analysi novel staphylococcus aureus lineag wild captiv macaqu staphylococcus aureus widespread common opportunist bacterium colonis infect human well wide rang anim studi methicillin suscept aureus mssa methicillin resist aureus mrsa isol monkey ape lemur indic presenc number poor unknown lineag pathogen order obtain insight staphylococc divers sequenc strain wild captiv individu three macaqu speci macaca mulatta assamensi sylvanus use nanopor illumina technolog strain previous identifi microarray poor unknown strain isol novel lineag st st st st st st st st st st st st st st st st st st st st sequenc characteris first time addit isol belong st lineag also observ human st mrsa strain alreadi known macaqu also includ studi mobil genet element genom island carriag prophag analys evid novel host specif virul factor howev conspicu high rate carriag pathogen island harbour edinb etd ete well higher number repeat unit within gene sasg encod adhes factor human isol observ none strain harbour gene encod panton valentin leukocidin conclus wildlif includ macaqu may harbour unappreci divers aureus lineag may clinic relev human livestock wildlif conserv given declin state mani wildlif popul | D055624;D013203 | T007;T047 |
36,232,528 | nicotinamid mononucleotid prevent retin dysfunct mous model retin ischemiareperfus injuri retin ischemiareperfus ir injuri caus sever vision impair retin ir injuri associ patholog increas reactiv oxygen speci inflamm result retin neuron cell death date effect therapi develop nicotinamid mononucleotid nmn key nicotinamid adenin dinucleotid nad intermedi shown exert neuroprotect retin diseas howev remain unclear whether nmn prevent retin ir injuri thus aim determin whether nmn therapi use retin ir injuri induc retin degener one day nmn intraperiton ip inject adult mice subject retin ir injuri mice inject nmn everi day three day electroretinographi immunohistochemistri use measur retin function alter retin inflamm respect protect effect nmn administr examin use retin cell line w cocl induc oxid stress condit nmn ip inject signific suppress retin function damag well inflamm nmn treatment show protect effect oxid stress induc cell death antioxid pathway nrf hmox activ nmn treatment conclus nmn could promis prevent neuroprotect drug ischem retinopathi | D018696;D015427 | T121;T169;T037 |
36,232,527 | egg protein transferrin deriv peptid irw lle arg trp iqw lle gln trp prevent obes mous model induc high fat diet via reduc lipid deposit reprogram gut microbiota egg deriv peptid play import role insulin secret sensit oxid stress inflamm suggest possibl involv obes manag henc aim studi explor allevi effect irw lle arg trp iqw lle gln trp obes via mous model induc high fat diet entir experiment period last eight week result demonstr iqw prevent weight gain decreas glucos low densiti lipoprotein ldl malonaldehyd triglycerid total cholesterol tc leptin level increas concentr adiponectin p lt n although irw fail prevent weight gain reduc concentr glucos high densiti lipoprotein hdl ldl leptin increas concentr adiponectin p lt n moreov irw iqw increas glucos toler insulin resist base result intraperiton glucos test insulin toler test p lt n quantit polymeras chain reaction result reveal irw iqw downregul mrna express dgat diacylglycerol acyltransferas dgat diacylglycerol acyltransferas tnf il il liver tissu p lt n result ribosom rna amplicon sequenc show iqw irw tend reduc relat abund firmicut parabacteroid irw enhanc abund bacteroid p lt n collect irw iqw supplement could allevi progress obes due fact supplement reduc lipid deposit maintain energi balanc reprogram gut microbiota | D000069196;D061385 | T007;T001;T121 |
36,232,526 | lithium treatment improv cardiac dysfunct rat depriv rapid eye movement sleep rapid eye movement rem sleep depriv trigger mania induc cardiac fibrosi beyond neuroprotect lithium cardioprotect potenti antifibrot activ studi investig whether lithium improv rem sleep depriv induc cardiac dysfunct evalu potenti mechan transthorac echocardiographi histopatholog analysi western blot analysi perform control rem sleep depriv rat without lithium treatment licl mmolkgday administ oral gavag week vivo isol ventricular prepar result reveal rem sleep depriv rat exhibit impair contractil greater fibrosi control lithium treat rem sleep depriv rat western blot analysi show rem sleep depriv heart higher express level transform growth factor beta tgf phosphoryl smad alpha smooth muscl actin lithium treat rem sleep depriv control heart moreov lithium treat rem sleep depriv heart lower express angiotensin ii type receptor phosphoryl nuclear factor kappa b p calcium releas activ calcium channel protein transient receptor potenti canon trpc trpc rem sleep depriv heart find suggest lithium attenu rem sleep depriv induc cardiac fibrogenesi dysfunct possibl downregul tgf angiotensin ii ca signal | D006331;D012895 | T047;T042;T041 |
36,232,525 | age relat low bone miner densiti cbl mice reflect aberr bone morphogenet protein signal observ human patient diagnos osteoporosi osteoporosi op bone disord character decreas bone miner densiti bmd bone morphogenet protein bmp inject use promot bone format op patient howev patient unrespons bmp display upregul bmp receptor type bmpria protein kinas ck ck synthet produc peptid name casein kinas ck util bmp signal pathway enhanc osteogenesi primari osteoblast isol op patient wherea bmp although shown op patient current reliabl mous model studi bmp ck signal public show bmpria requir ck mediat osteogenesi cc cell crispr cas mediat gene knockout bmpria util cbl b mous strain age model studi aberr bmp signal demonstr like op patient month mice bmp increas bone growth display upregul bmpria ck protein express furthermor ck enhanc osteogenesi decreas osteoclastogenesi age group wherea bmp increas miner month mice increas osteoclast format age group data demonstr age b mice reliabl model mimick data obtain op patient | D047390;D010024 | T047;T126;T116 |
36,232,524 | methamphetamin induc system inflamm anxieti role gut immun brain axi methamphetamin meth high addict drug abus million user worldwid thus becom global health concern limit manag option ineffici exist treatment method driven research understand mechan under meth induc disord find effect treatment studi aim understand complex interact gastrointestin immun nervous system follow acut meth dose administr one potenti under molecular mechan concentr impact meth abus gut permeabl find show decreas express tight junction protein zo epcam intestin tissu presenc fabp sera meth treat mice suggest intestin wall disrupt increas presenc cd immun cell intestin wall confirm gut wall inflammationdisrupt brain express inflammatori marker ccl cxcl il tmem presenc albumin higher meth mice compar sham suggest meth induc blood brain barrier disrupt spleen cellular gene chang also note addit mice treat acut dose meth show anxious behavior dark light open field elev maze test compar sham control find meth induc inflamm anxieti may provid opportun develop effect treatment meth addict futur | D019969;D000697;D008694 | T121;T109;T131;T048 |
36,232,523 | genom wide identif character nf ya gene famili express respons differ nitrogen form populus canescen nf ya gene famili class conserv transcript factor play import role plant growth develop respons abiot stress poplar model organ studi rapid growth woodi plant need consum mani nutrient howev studi respons nf ya gene famili nitrogen woodi plant limit studi conduct systemat comprehens bioinformat analysi nf ya gene famili base populus canescen genom data total pcnf ya gene identifi map chromosom accord amino acid sequenc characterist genet structur nf ya domain pcnf yas divid five clade gene duplic analysi reveal five pair replic fragment one pair tandem duplic pcnf ya gene pcnf ya gene promot region rich differ cis act regulatori element among myb myc element abund among pcnf ya gene contain bind site p canescen mir addit rt qpcr data root wood leav bark p canescen show differ spatial express profil pcnf ya gene transcriptom data rt qpcr analysi show express pcnf ya gene alter treatment differ nitrogen form furthermor function pcnf ya gene transgen poplar analyz potenti role pcnf ya gene respons poplar root differ nitrogen form reveal indic gene regul root growth develop | D032107 | T002 |
36,232,522 | experiment research model assess cross reactiv f human psa two differ perspect similar antigen structur includ degre correspond amino acid sequenc spatial structur alway reflect actual cross reactiv allergen inhibit test appear invalu tool assess potenti cross reactiv allergen natur condit public present two experiment model inhibit test solid phase sp liquid phase lp exemplari research model use cross reactiv human psa anti f ige antibodi perform sp model use micropl coat human psa lp model base mix anti f ige posit serum materi contain human psa anti f ige psa concentr inhibit measur evalu inhibit effect result perform experi show propos model inhibit test effect tool studi cross reactiv relationship antigen sp concentr anti f decreas lp decreas turn psa concentr sp decreas lp decreas conclus sp lp seem effect tool assess actual cross reactiv differ allergen | D007073;D017430 | T126;T116;T129 |
36,232,521 | use steam process improv biochem activ polygonatum sibiricum polysaccharid galactos induc memori impair mice polysaccharid polygonatum sibiricum psp possess antioxid antiag neuroprotect activ howev whether steam process influenc biolog activ psp especi age relat memori impair yet known studi polygonatum sibiricum rhizom subject nine steam nine dri process psps differ steam time abstract thereaft physicochem properti qualifi antioxid activ psps evalu gal induc ht cell model effect psps psp psp psp memori evalu use gal injur mice result show steam psps low ph valu larg negat charg share similar main chain substitu cellular experi show antioxid activ steam psps increas psp psp psp could signific amelior memori impair gal injur mice psp show optim effect meanwhil psp demonstr best effect term prevent cell death synapt injuri gal injur mice addit steam psps increas anti oxid stress relat protein express decreas inflamm relat protein express gal injur mice collect steam process improv effect psps gal induc memori impair mice like increas antioxid activ psps | D031384 | T002 |
36,232,520 | identif gene famili bamboo character pe b reveal potenti role promot growth protein famili play import role regul plant growth develop gene famili report multipl speci howev littl known gene famili bamboo studi total gene belong famili identifi three repres bamboo speci ie olyra latifolia phyllostachi eduli bonia amplexicauli whose encod protein group non group phylogeni analysi protein arabidopsi thaliana oryza sativa divers gene structur motif characterist among three bamboo speci collinear analysi suggest gene famili bamboo undergon strong purif select evolut tissu specif express analysi show express pe vari differ tissu p eduli suggest function divers growth develop co express analysi show four pe co express posit eight ribosom gene yeast two hybrid yh assay show pe bd could interact peribosom qpcr result demonstr pe b peribosom similar express trend increas shoot height confirm would work togeth particip shoot growth develop bamboo addit transgen arabidopsi plant overexpress pe b longer root larger stem diamet earlier bolt time faster growth rate wild type arabidopsi indic pe b act growth promot result provid comprehens inform gene bamboo highlight pe b potenti target bamboo improv | D017360;D018506 | T045;T002 |
36,232,519 | janus face hmgb post aneurysm subarachnoid hemorrhag asah inflamm aneurysm subarachnoid hemorrhag asah result major ruptur intracrani aneurysm potenti devast diseas high morbid mortal bleed aneurysm success secur howev toxic mechan impact blood extravas subarachnoid space damag brain cell lead releas differ damag associ molecular pattern molecul damp damp upregul inflamm bind cognat receptor immun cell under earli delay brain injuri asah moreov molecul also associ differ post asah complic lead poor clinic outcom among damp hmgb repres prototyp protein damp well character proinflammatori role asah differ post asah complic howev recent investig uncov yet anoth face hmgb involv promot brain tissu remodel neurovascular repair anti inflammatori effect sah differ face reli differ redox state hmgb cours time sah elucid dynam redox state hmgb high biomark well therapeut potenti review main highlight recent find along convent describ normal role hmgb nuclear protein proinflammatori molecul diseas asah | D024243;D013345 | T047;T046;T123;T116 |
36,232,518 | necroptosi contribut lps induc activ hypothalam pituitari adren axi piglet model stressor caus activ hypothalam pituitari adren hpa axi system inflammatori respons newli propos cell death manner recent year necroptosi occur varieti tissu damag inflamm howev role necroptosi hpa axi activ remain elucid aim studi investig occurr necroptosi role hpa activ porcin stress model induc escherichia coli lipopolysaccharid lps sever typic stress behavior like fever anorexia shiver vomit observ piglet lps inject hpa axi activ shown increas plasma cortisol concentr mrna express pituitari corticotropin releas hormon receptor crhr adren steroidogen acut regulatori protein star mrna express tumor necrosi factor tnf interleukin il il hypothalamus pituitari gland adren gland elev lps accompani activ necroptosi indic higher mrna express necroptosi signal includ receptor interact protein kinas rip rip phosphoryl mix lineag kinas domain like protein mlkl furthermor necrostatin nec inhibitor necroptosi inhibit necroptosi indic decreas mrna level rip rip mlkl phosphoglycer mutas famili member pgam hypothalamus pituitari gland adren gland nec also decreas mrna express tnf il inhibit activ hpa axi indic lower plasma cortisol concentr mrna express adren type melanocortin receptor mcr star find suggest necroptosi present contribut hpa axi activ induc lps find provid potenti possibl necroptosi intervent target allevi hpa axi activ stress respons | D007030;D010913 | T022;T030 |
36,232,517 | anticoagul monitor activ partial thromboplastin time anti xa activ intens care unit patient interest thrombin generat assay current guidelin recommend monitor anticoagul effect unfraction heparin ufh measur anti xa activ rather activ partial thromboplastin time aptt intens care unit icu patient primari object studi evalu correl aptt anti xa activ thrombin generat ufh treat icu patient prospect observ pilot studi conduct adult surgic icu patient treat ufh aptt anti xa activ monitor daili therapeut target aptt andor anti xa uml correl among aptt anti xa activ thrombin generat determin measur endogen thrombin potenti etp inflammatori respons evalu c reactiv protein crp use marker inflammatori respons plasma sampl icu patient analyz correl aptt anti xa activ ci p lt although thrombin generat aptt anti xa correl inflammatori respons correl higher thrombin generat anti xa activ compar aptt aptt therapeut rang low thrombin generat observ inhibit anti xa therapeut rang coagul test aptt anti xa correl thrombin generat decreas thrombin generat observ anti xa within therapeut rang work need evalu coagul biomark respons clinic outcom specif icu popul | D006493;D013917 | T116;T121;T109;T126;T123 |
36,232,516 | integr transcript network reveal spatial molecular interplay under alantolacton inulin biosynthesi inula racemosa hook f inula racemosa hook f pushkarmula perenni himalayan herb known aromat phytopharmaceut attribut yet explor genomictranscriptom scale studi effort made unveil global transcript atlas under organ specif special metabolit biosynthesi integr rna seq analysi million sequenc read phytochem analysi leaf stem root tissu overal assembl nonredund unigen identifi exhibit spatial express leaf root stem subsequ integr predict transcript interactom network unigen edg gene ontolog kegg pathway enrich analysi reveal isoprenoid terpenoid diterpenoid gibberellin biosynthesi antimicrobi activ root tissu interest root specif express germacren mediat alantolacton biosynthesi gas gao gh ipp dmap kao antimicrobi activ bzr defl ltp well support quantit express profil phytochem accumul alantolacton g mg isoalantolacton g mg suggest root site alantolacton biosynthesi signific interact leaf specif carbohydr metabol root specif inulin biosynthesi indic sourc leaf sink root regul inulin find comprehens demonstr sourc sink transcript regul alantolacton inulin biosynthesi extend upscal target special metabolit nevertheless genom resourc creat studi also util develop genom wide function relev molecular marker expedit breed strategi genet improv racemosa | D000890;D004224;D038143 | T121;T109;T002 |
36,232,515 | identif character circular rnas involv flower develop senesc rhododendron delavayi amp nbsp franch floral develop senesc crucial determin econom ornament valu circrna play essenti role regul plant growth develop howev systemat identif circrna lifespan flower studi aim explor express profil function role circrna full flower stage rhododendron delavayi franch carri transcriptom sequenc six stage rhododendron delavayi franch flower identifi circular rna express profil addit use bioinformat method explor function circrna includ analysi circrna mirna mrna network short time seri express miner stem identifi circrna differenti express bud fade stage furthermor use stem analysi one circrna express model profil signific upregul senesc stage includ circrna addit circrna mirna mrna network construct differenti express circrna target mrna may regul develop senesc rhododendron flower final analyz correl circrna mrna combin exist report propos circrna play regulatori role flower develop senesc mediat jasmon signal pathway overal result provid new clue potenti mechan circrna act novel post transcript regul develop senesc process flower | D035683;D029793 | T123;T002;T114 |
36,232,514 | diphenyl diselenid allevi tert butyl hydrogen peroxid induc oxid stress lipopolysaccharid induc inflamm rat glomerular mesangi cell hyperglycemia oxid stress inflamm play key role onset develop diabet complic diabet nephropathi dn diphenyl diselenid dpds stabl simpl organ selenium compound anti hyperglycem anti inflammatori anti oxid activ nevertheless vitro role molecular mechan dpds dn remain unknown therefor investig effect dpds tert butyl hydrogen peroxid bhp induc oxid stress lipopolysaccharid lps induc inflamm rat glomerular mesangi hbzi cell explor under mechan dpds attenu bhp induc cytotox concurr decreas intracellular ros mda content increas sod activ gsh content moreov dpds augment protein mrna express nrf ho nqo gclc bhp stimul hbzi cell addit dpds suppress lps induc elev intracellular content mrna express interleukin il il tnf furthermor lps induc nfb activ high phosphoryl jnk erk mark suppress dpds hbzi cell summari data demonstr dpds improv bhp induc oxid stress activ nrfkeap pathway also improv lps induc inflamm via inhibit nfbmapk pathway hbzi cell suggest dpds potenti develop candid prevent treatment dn | D003928;D012643 | T121;T047;T123;T196 |
36,232,513 | mesenchym stem cell deriv extracellular vesicl propos therapi rat model cerebr small vessel diseas mesenchym stem cell deriv extracellular vesicl msc ev employ past decad therapeut agent various diseas includ central nervous system cns disord current aim use msc ev potenti treatment cerebr small vessel diseas csvd complex disord varieti manifest msc ev intranas administr salt sensit hypertens prone sbhi rat doca salt load sbhi ds previous shown model csvd msc ev accumul within brain lesion site sbhi ds vitro model inflammatori environ brain demonstr anti inflammatori properti msc ev follow vivo msc ev treatment gene set enrich analysi gsea sbhi ds cortic reveal downregul immun system respons relat gene set addit msc ev downregul gene set relat apoptosi wound heal coagul upregul gene set associ synapt signal cognit specif gene mark alter upon treatment synergist effect gene altern suffici increas anim surviv improv neurolog state affect sbhi ds rat data suggest msc ev act microenviron modul various molecular pathway conclud msc ev may serv benefici therapeut measur multifactori disord csvd | D059345;D064791;D000067128;D059630 | T047;T026;T121;T109;T025;T125 |
36,232,512 | remov copper ii aqueous environ use silk sericin deriv carbon sericin product silk industri recycl contribut environment protect sustain develop cocoon silk industri paper basi realiz sericin enrich solut cu ii adsorpt capac sericin deriv carbon sc prepar differ pyrolysi temperatur studi sc character use scan electron microscopi sem zeta potenti effect initi concentr cu ii ph adsorpt temperatur contact time adsorpt process evalu follow investig mechan cu ii adsorpt sc result show sc porous structur provid site cu ii adsorpt maximum adsorpt capac cu ii onto sc mgg obtain adsorpt temperatur c ph addit pseudo second order kinet model langmuir isotherm model correct describ adsorpt process cu ii onto sc therefor sc act potenti adsorb remov cu ii water studi help promot effect use cocoon silk resourc | D047030;D014874 | T121;T131;T123;T116 |
36,232,511 | role mesenchym stem cell extracellular vesicl idiopath pulmonari fibrosi idiopath pulmonari fibrosi ipf progress interstiti fibrot diseas lead disabl death within year diagnosi pulmonari fibrosi diseas multifactori etiolog concept aberr regener pulmonari epithelium reveal pathogenesi ipf accord repeat damag death alveolar epitheli cell main mechan lead develop progress ipf cell death provok migrat prolifer activ fibroblast overproduc extracellular matrix result fibrot deform lung tissu mesenchym stem cell mscs extracellular vesicl ev promis therapi pulmonari fibrosi mscs ev deriv mscs modul activ immun cell inhibit express profibrot gene reduc collagen deposit promot repair damag lung tissu review consid molecular mechan develop ipf multifacet role mscs therapi ipf current ev mscs regard promis cell free therapi tool review discuss result avail date use ev mscs lung tissu repair | D000067128;D054990;D059630 | T026;T025;T047 |
36,232,510 | tryptamin microbi metabolit ferment rice bran suppress lipopolysaccharid induc inflamm murin macrophag model ferment thought alter composit bioavail bioactiv compound rice bran howev process affect anti inflammatori effect rice bran bioactiv compound might particip function yet elucid studi aim isol bioactiv compound ferment rice bran play key role anti inflammatori function ferment rice bran fraction use success solvent solid phase extract ferment rice bran fraction appli lipopolysaccharid lps activ murin macrophag evalu anti inflammatori activ hot water fraction frba ethanol fraction frbb n hexan fraction frbc shown abl suppress pro inflammatori cytokin express lps stimul raw cell subsequ fraction hot water fraction frbf frbe also abl reduc inflammatori respons cell lps investig reveal tryptamin bacteri metabolit tryptophan abund present extract result indic tryptamin may play import role anti inflammatori effect ferment rice bran furthermor anti inflammatori effect frbe tryptamin may depend activ aryl hydrocarbon receptor | D008070;D012275 | T109;T168;T002 |
36,232,509 | inhibit gaba r applic lactobacillus casei zhang allevi ulcer coliti mice gaba r potenti target intestin epitheli renew repair emerg evid indic gamma aminobutyr acid type receptor gaba r lactobacillus casei zhang regul coliti varieti way particip host immun inflammatori respons alter gut microbiota influenc intestin barrier function howev much known mechan gaba r l casei affect colon epitheli cell renew interact gaba r l casei process elucid establish dextran sulfat sodium dss induc model measur mous bodi weight colon length diseas activ index dai histolog score result indic inhibit gaba r allevi dss induc coliti symptom result less weight loss intact colon tissu moreov treatment bicucullin bic gaba r inhibitor increas level pcna catenin tcf mice coliti interest open field test perform show inhibit gaba r also attenu coliti relat anxieti like behavior rna gene sequenc analysi show inhibit gaba r partial revers gut dysbacteriosi dss induc mice increas abund benefici bacteria addit l casei zhang supplement inhibit express gaba r mice coliti promot prolifer renew colon epitheli cell allevi anxieti like behavior intestin microflora disord mice thus gaba r play key role benefici effect l casei dss induc coliti mice | D003092;D003093;D007780 | T007;T047 |
36,232,508 | amidas contribut full virul sclerotinia sclerotiorum sclerotinia sclerotiorum one notori ubiquit soilborn plant pathogen caus serious econom loss larg number host worldwid although virul factor identifi filament fungus includ various cell wall degrad enzym toxin oxal acid effector understand virul strategi far complet explor novel factor contribut diseas new pipelin combin forward genet screen next generat sequenc util studi analysi hypovirul mutant reveal mutat amidas encod gene sscleg result reduc virul first report contribut amidas fungal virul like affect oxal acid homeostasi | D019815;D037521 | T131;T121;T109;T123;T130 |
36,232,507 | new chemotact mechan govern long rang angiogenesi induc patch arteri graft vein chemotaxi migrat cell respons chemic stimulus import concept angiogenesi model angiogenesi model chemotaxi defin migrat sprout tip respons upgradi vegf vascular endotheli growth factor howev found angiogenesi induc perform arteri patch graft rabbit occur decreas vegfa gradient data show vegfa concentr peak approxim cm away arteri patch decreas measur approach patch also observ new blood vessel form twist congest area distinguish manner non patholog blood vessel explain observ develop mathemat model compar result numer simul experiment data introduc new chemotact veloc use tempor chang chemoattract gradient govern sprout tip migrat perform hybrid simul illustr growth new vessel result indic speed growth new vessel oscil reach peripheri arteri patch crowd congest blood vessel format observ numer simul thus numer simul result agre experiment data | D009389;D042461 | T046;T123;T116 |
36,232,506 | chang proxim tubular reabsorpt modul microvascular regul via tgf system review paper consid consequ modul tubular reabsorpt proxim macula densa sodium glucos co transport sglt inhibitor acetazolamid furosemid state glomerular hyperfiltr sglt inhibitor improv renal function earli advanc diabet nephropathi decreas glomerular filtrat rate gfr presum activ tubuloglomerular feedback tgf mechan central paper renoprotect effect sglt inhibitor diabet nephropathi partial explain tgf activ altern explan sustain activ tgf lean two prerequisit partial adapt occur reabsorpt proxim macula densa partial adapt occur tgf respons main proxim tubular loop henl sodium transport sodium hydrogen exchang nhe sglt na k cl co transport nkcc sglt inhibitor acetazolamid furosemid import compound inhibit transport would decreas sodium reabsorpt upstream macula densa increas tgf activ could direct indirect affect tgf respons could oppos sustain tgf activ sglt inhibitor sustain activ tgf partial compens tubular reabsorpt tgf respons sglt inhibitor shown preserv gfr earli advanc diabet nephropathi earli diabet nephropathi solid physiolog basi effect advanc nephropathi lack addit tgf hard studi human therefor role tgf remain elus review also consid altern explan renoprotect effect sglt inhibitor diabet patient enhanc microvascular network function furthermor combin use sglt inhibitor angiotensin convert enzym inhibitor acei angiotensin receptor blocker arb diabet decreas inflammatori pathway improv renal oxygen delay progress diabet nephropathi | D003928;D000077203 | T121;T047;T109 |
36,232,505 | role regulatori cell deriv extracellular vesicl human diseas regulatori treg cell play crucial role maintain immun self toler immun homeostasi close associ mani human diseas recent treg cell deriv extracellular vesicl treg ev demonstr novel cell contact independ inhibitori mechan treg cell treg ev contain mani specif biolog molecul deliv target cell modul immun respons inhibit cell prolifer induc cell apoptosi chang cytokin express profil target cell abnorm quantiti function treg ev associ sever type human diseas condit transplant reject inflammatori diseas autoimmun diseas cancer treg ev promis novel potenti target diseas diagnosi therapi drug transport moreov treg ev possess distinct advantag treg cell base immunotherapi howev therapeut potenti treg ev limit factor standard protocol isol purif larg scale product drug load effici review systemat describ structur compon function basic mechan action treg ev discuss emerg role pathogenesi potenti applic treg ev human diseas | D000067128;D050378 | T026;T025 |
36,232,504 | express analysi moritella viscosa challeng atlant salmon identifi diseas respond gene microrna predict target gene pathway moritella viscosa bacteri pathogen caus winter ulcer diseas atlant salmon lesion affect fish lead increas mortal decreas fish welfar inferior meat qualiti farm salmon microrna mirna small non code rnas involv post transcript regul guid mirna induc silenc complex specif mrna transcript target gene goal studi identifi mirna respond moritella viscosa salmon investig mirna express head kidney muscleskin lesion site caus pathogen protein code gene express investig microarray analysi materi seventeen differenti express guid mirna gde mirna identifi head kidney thirti nine lesion site microarray analysi reproduc differenti express signatur sever thousand gene known infect respons silico target predict enrich analysi suggest gde mirna predict target gene involv immun respons hemostasi angiogenesi stress respons metabol cell growth apoptosi major conserv gde mirna eg mir mir mir mir mir mir mir known infect respons vertebr collect find indic gde mirna import post transcript gene regul host respons bacteri infect | D035683;D034221;D020317 | T007;T123;T013;T114 |
36,232,503 | vitro inhibitori effect select asteracea plant pancreat lipas follow phenol content identif liquid chromatographi high resolut mass spectrometri lc hrms pancreat lipas pnlip ec play pivot role digest dietari lipid metabol pathway direct relat obes one effect strategi obes treatment inhibit pnlip possibl achiev specif phenol compound occur high abund plant studi multidisciplinari approach present investig pnlip inhibitori effect plant belong asteracea botan famili first stage studi rapid cost effici pnlip assay microwel plate format develop import paramet optim eg enzym substrat upon pnlip assay optim aqueous dichloromethan asteracea plant extract test cut inhibit level set analyz sampl signific inhibitori effect inhibitori rate gt use ultra high perform liquid chromatographi hybrid quadrupol time flight mass spectrometri uhplc q tof ms method specif metabolom suspect screen perform phenol compound tentat identifi includ phenol acid flavonoid flavonoid glycosid flavonoid glycosid amongst other case aqueous extract phytochem known induc pnlip inhibitori effect eg compound contain galloyl molecul caffeoylquin acid monitor chrysanthemum morifolium grindella camporum hieracium pilosella extract present approach combin vitro bioactiv measur high end metabolom identifi phenol compound potenti medicin andor dietari applic | D019659 | T002 |
36,232,502 | effect dietari glycinin oxid damag apoptosi tight junction intestin juvenil hybrid yellow catfish pelteobagrus fulvidraco pelteobaggrus vachelli object studi examin influenc glycinin growth intestin structur integr relat oxid damag apoptosi tight junction juvenil hybrid yellow catfish pelteobagrus fulvidraco pelteobaggrus vachelli fish initi weight g fed diet contain five differ level glycinin week result demonstr dietari glycinin level negat correl final weight feed intak protein effici ratio surviv rate experi fish level dietari glycinin exceed structur integr posterior intestin observ impair character disord exfoli margin intestin villi blur broken boundari tight junction damag organell cell vacuol level dietari glycinin depress total antioxid capac total superoxid dismutas activ posterior intestin furthermor high level dietari glycinin linear quadrat regul mrna express claudin occludin zo linear signific regul mrna express bax cyt c caspas caspas p posterior intestin conclus dietari glycinin impair morpholog structur posterior intestin induc oxid stress cell apoptosi eventu imped growth perform juvenil hybrid yellow catfish | D002397 | T013 |
36,232,501 | hypoxia induc factor signal osteogenesi skelet repair suffici oxygen requir maintain normal cellular physiolog function creatur develop breed homeostasi late research report patholog hypoxia environment hypoxia might affect bone health adapt hypoxia pivot cellular event normal cell develop differenti patholog set ischemia central mediat homeostasi hypoxia induc transcript factor hif allow cell surviv low oxygen environ essenti regul osteogenesi skelet repair perspect summar role hif hif signal pathway implic bone develop skelet repair outlin molecular mechan regul downstream growth factor protein molecul vegf epo present opportun develop therapi bone regener | D010012;D042461 | T042;T123;T116 |
36,232,500 | integr atac seq rna seq reveal dynam chromatin access gene express appl respons drought drought resist plant influenc multipl signal pathway involv various transcript factor mani target gene multipl type epigenet modif studi epigenet modif drought focus dna methyl histon modif fewer chromatin remodel chang chromatin access play import role abiot stress plant affect rna polymeras bind various regulatori factor howev chang chromatin access drought appl well understood studi landscap chromatin access associ gene express appl gl drought condit analyz assay transposas access chromatin high throughput sequenc atac seq rna seq differenti analysi drought treatment control identifi peak upregul chromatin access peak downregul access drought induc chromatin access chang gene main enrich metabol stimulus bind pathway combin result differenti analysi rna seq atac seq identifi gene higher chromatin access increas gene express drought condit may play import function drought respons process among total nine transcript factor gene identifi includ athb hat wrki transcript factor gene differenti express differ chromatin access motif bind loci may particip appl respons drought regul downstream gene studi provid refer chromatin access drought stress appl result facilit subsequ studi chromatin remodel transcript factor | D000081204;D027845 | T168;T063;T002 |
36,232,499 | effect pt decor optic properti pristin defect mos ab initio studi use structur relax calcul first principl molecular dynam fpmd perform numer simul explor interact mos surfac platinum atom calcul optic properti result materi explor three initi posit interact pt atom pristin mos surfac plus anoth posit pt mos surfac sulfur vacanc v surfac absorb pt atom case consid absorpt energi rang ev ev calcul optic properti band structur two case largest absorpt energi ev ev pristin mos semiconductor gap around ev adsorpt pt atom ev case materi reduc band gap ev addit optic absorpt visibl rang great increas energi band structur mos sulfur vacanc v show band gap ev consequ chang optic properti adsorpt pt atom v vacanc materi band gap ev case optic absorpt visibl rang increas eight time reflect infrar rang get rough doubl situat pt absorb atom consid final perform two fpmd run k test stabil case lowest highest absorpt energi observ confirm qualit result obtain structur relax | D008982;D010984 | T123;T196 |
36,232,498 | extract dendrobium allevi dri eye diseas rat model regul aquaporin express mapksnf b signal dri eye one common ocular surfac diseas caus tear film instabl ocular surfac damag due abnorm qualiti quantiti tear inflammatori factor initi relev transduct signal pathway trigger inflammatori cascad respons result ocular surfac inflamm shown activ ingredi dendrobium polysaccharid alkaloid phenol anti inflammatori anti tumour immun boost effect dendrobium officinal extract improv glandular secret function increas salivari secret increas express level water channel protein salivari gland patient dri eye syndrom investig vitro cytoprotect effect dendrobium extract sodium chlorid induc hyperosmot condit human cornea keratocyt hks result show dendrobium officinal kimura et migo water extract dow dendrobium loddigesii rolf water extract dlw could upregul express aquaporin aqp protein thus exert repair effect promot cell migrat furthermor oral administr dow dlw enhanc tear product rat exert protect effect ocular surfac damag dow dlw could upregul express aqp mucin muc ac protein lacrim gland reduc inflammatori respons dow dlw inhibit activ correspond mitogen activ protein kinas mapk nf kb pathway therebi play role improv dri eye symptom studi provid new perspect dri eye treatment dow dlw may potenti therapeut agent dri eye | D031667;D015352 | T047;T184;T002 |
36,232,497 | influenc sever earli chronic kidney diseas oxid stress patient without type diabet mellitus earli chronic kidney diseas ckd condit tend progress end stage kidney diseas eskd earli diagnosi kidney diseas earli stage reduc complic alter renal function repres complic diabet mellitus dm mechan under progress ckd diabet could associ oxid inflammatori process studi aim evalu state inflamm oxid stress os progress ckd earli stage patient without type diabet mellitus tdm analyt cross section studi carri patient ckd earli stage without tdm elisa method determin express pro inflammatori cytokin il tnf well lipoperoxid lpo nitric oxid superoxid dismutas activ sod colorimetr method determin glutathion peroxidas gpx total antioxid capac tac patient ckd tdm signific decreas antioxid defens sod p lt gpx p lt tac p lt compar patient without tdm consequ patient tdm higher concentr oxid marker p lt inflamm marker il p lt tnf patient without tdm ckd stage relat oxid antioxid inflammatori marker outcom tdm patient patient without tdm present increas sod p decreas p lt stage ckd increas conclus patient tdm present higher level oxid inflammatori marker accompani decreas antioxid defens howev oxid status marker associ ckd stage progress patient without tdm thus sod marker could help detect earli stage ckd patient yet develop metabol comorbid tdm | D003924;D051436 | T047 |
36,232,496 | slow evolut toward super aggreg oligom form swap rnase n termini wish amyloidosi nativ monomer rnase oligomer upon lyophil acet acid solut heat high concentr various solvent way produc mani dimer oligomer conform three dimension domain swap ds mechan involv rnase n orand c termini found mani oligom evolv toward neglig amount larg deriv store month c phosphat buffer call speci super aggreg sas notabl sas origin nativ rnase monom oligom character exclus presenc c terminus swap enzym subunit well instead swap least two subunit n termini mandatori produc immunoblot sas confirm deriv rnase even retain low ribonucleolyt activ interact regist thioflavin tht addit tem analys indic sas larg circular amyloid like deriv confirm rnase act auto chaperon although display mani amyloid prone short segment includ loop includ n terminus therefor hypothes open rnase n terminus henc oligomer ds may repres preliminari step favor massiv rnase aggreg interest process slow requir low temperatur limit concomit oligom dissoci nativ monom data hypothesi propos discuss light protein aggreg general possibl futur applic contrast amyloidosi | D000686;D012259 | T047;T126;T116 |
36,232,495 | neuro inflamm modul post traumat brain injuri lesion bench bed side head trauma common caus disabl young adult known silent epidem caus mosaic symptom whether neurolog sensori motor deficit psychiatr depress anxieti symptom somat vertigo tinnitus phosphen furthermor cranial trauma ct children present sever particular term epidemiolog mechan physiopatholog notabl link attack immatur organ adult head trauma children lifelong repercuss caus social famili isol difficulti school later socio profession advers improv manag pre hospit rehabilit cours patient reduc secondari morbid mortal often without long term disabl one hypothes contributor process chronic neuroinflamm could accompani primari lesion facilit develop tertiari lesion neuroinflamm complex process involv differ actor glial cell astrocyt microglia oligodendrocyt permeabl blood brain barrier excitotox product oxygen deriv cytokin releas tissu damag neuron death sever studi investig effect various treatment neuroinflammatori respons traumat brain injuri vitro anim human model aim review examin various anti inflammatori therapi implement | D000070642;D007249 | T046;T037 |
36,232,494 | metal cluster trigger assembl heterogen au ag nanoclust high load perform biocompat capabl work first report prepar heterogen assembl structur au ag nanoclust ncs good drug carrier high load perform biocompat capabl glutathion protect au ag cluster self assembl porous au ag ncs size valu nm morpholog character reveal diamet au ag ncs approxim nm well correspond potenti abil load perform metal cluster trigger assembl process compar individu compon stabil load perform heterogen au ag ncs improv exhibit relat biocompat enhanc exact inform cell viabil approxim cell incub g ml particl solut day drug releas adriamycin au ag ncs carri pbs ph respect simul vivo tumor microenviron releas effici could reach ph less ph use ultrasound field extern environ acceler assembl process metal cluster trigger assembl au ag ncs size morpholog assembl au ag ncs control use differ power paramet w w w ambient atmospher overal novel approach exhibit convey assembl work metal cluster trigger heterogen structur porous characterist exist properti water solubl stabil low toxic capsul consid depend agent various biomed applic drug carrier immunotherapi | D006046;D053768 | T121;T196;T073 |
36,232,493 | transcriptom analysi reveal complex regulatori pathway background color juvenil plectropomus leopardus skin color variat fish skin color often strong affect background color hypothes regulatori mechan variat skin color p leopardus link background color studi conduct transcriptom analysi plectropomus leopardus cultur differ background color compar gene express level import signal pathway rna seq analysi yield known mrnas novel mrnas differenti express gene deg deg relat melanin synthesi screen key melanin relat gene identifi specif tyr slca mcr ednrb dct tat wnt deg main involv melanogenesi includ tyrosin metabol wnt signal pathway camp signal pathway express level key gene upregul background color deepen msh wnt gf mshcamp depend wnt catenin pikakt signal pathway activ result accumul intracellular mitf mitf promot melanin product bind tyr tyrp dct promot region present studi explor molecular mechan under darken skin color pattern p leopardus provid theoret basi molecular mechan under pigment p leopardus | D008543;D012880 | T042;T109;T123 |
36,232,492 | compar dft studi process control agent mechanochem synthesi pbte process control agent organ addit use regul balanc fractur mechan knead control size mill particl tributyl phosphat tbp evalu act surfac modifi pbte compar result obtain use formaldehyd ch order elucid natur interact tbp pbte surfac global local descriptor calcul via densiti function theori first tbp ch molecul structur optim vertic ionize energi well vertic electron affin calcul elucid molecul behav energet remov electron gain respect result compar obtain electrostat potenti map van der waal isosurfac infer theoret insight use propos adsorpt mode tbp ch pbte surfac usabl ration facet expos pbte surfac treatment optim structur compound system show close correl surfac energi shift pbte facet exhibit final wulff construct built compar usag tbp ch molecul pbte morpholog | D005557;D011789 | T121;T109;T131;T170 |
36,232,491 | identif novel renal metastasi associ cpg base dna methyl signatur rmam approxim patient renal cell cancer rcc present synchron metastat diseas time diagnosi metachron metastat diseas occur case within year recent advanc adjuv treatment aggress rcc follow surgeri suggest biomark base predict risk distant metastasi could improv patient select biometr analysi tcga kirc data identifi candid loci nk homeobox gene nkx hypermethyl primari metastat rcc analys nkx dna methyl three gene region includ total cpg site tumor adjac normal tissu rcc metastat tissu sampl metastas rcc patient reveal high signific tumor specif primari metastat specif metastat tissu specif hypermethyl nkx combin cpg site methyl data nkx metastasi associ gene ina nhlh thbs demonstr similar metastat tissu metastat primari rcc tissu random forest method evalu unknown test cohort tissu use receiv oper characterist curv analysi reveal metastat tissu differenti median area curv p random run analysi variabl import demonstr median contribut decis make least one cpg site gene suggest superior inform site annot nhlh nkx thus dna methyl nkx associ metastat state rcc tissu contribut four gene base statist predictor tumor metastat renal tissu | D002292;D007680 | T191 |
36,232,490 | role ghrelin system coliti hepat risk factor inflammatori relat cancer known exact lead develop colorect cancer crc hepatocellular carcinoma hcc specif risk factor increas probabl occurr unclear pathogenesi late diagnosi poor prognosi result high recurr metastasi rate repeat ineffect therapi cancer continu challeng basic scienc practic medicin ghrelin system compris ghrelin altern peptid eg obestatin growth hormon secretagogu receptor ghs rs ghrelin acyl transferas goat play import role physiolog patholog gastrointestin gi tract promot various physiolog effect includ energi metabol amelior inflamm ghrelin system play role pathogenesi inflammatori bowel diseas ibd well known risk factor develop crc well inflammatori liver diseas trigger develop hcc coliti associ cancer serv prototyp inflamm associ cancer littl known role ghrelin system mechan transform chronic inflamm low high grade dysplasia final crc hcc also associ chronic inflamm fibrosi aris differ etiolog includ alcohol nonalcohol fatti liver diseas nafld andor hepat b hbv hepat c virus hcv infect howev exact role ghrelin progress chronic inflammatori lesion hcc still unknown aim review summar find role ghrelin system inflammatori bowel liver diseas order better understand impact system develop inflammatori relat cancer name crc hcc | D006528;D003092;D006506;D006509;D006526;D008113 | T191;T047 |
36,232,489 | aerob exercis prevent arteri stiff attenu hyperexcit sympathet nerv perivascular adipos tissu mice transvers aortic constrict aim investig efficaci exercis prevent arteri stiff potenti role sympathet nerv within perivascular adipos tissu pvat pressur overload induc heart failur hf mice eight week old male mice subject sham oper sham transvers aortic constrict sedentari tac se transvers aortic constrict exercis tac ex group six week aerob exercis train perform use treadmil arteri stiff determin measur elast modulus elast collagen fiber aorta sympathet nerv distribut pvat observ circul noradrenalin ne express adrenerg receptor ar adiponectin pvat quantifi recoveri cardiac function aerob exercis thorac aortic collagen elast modulus cem collagen fiber signific decreas p lt tac se vs tac ex elastin elast modulus eem signific increas p lt tac se vs tac ex circul ne sympathet nerv distribut pvat signific decreas p lt tac se vs tac ex express ar signific reduc p lt tac se vs tac ex adiponectin signific increas p lt tac se vs tac ex pvat regular aerob exercis effect prevent arteri stiff extracellular matrix ecm remodel development cours hf sympathet innerv adiponectin within pvat might strong implic | D006333;D059289;D010805;D013564 | T038;T047;T046;T022 |
36,232,488 | valid appropri refer gene qrt pcr normal oat avena sativa l uv b high light stress oat food forag crop speci wide cultiv worldwid also import forag grass plateau region china high level ultraviolet radiat sunlight screen suitabl refer gene oat uv b high light stress prerequisit ensur accuraci real time quantit pcr qrt pcr data use plant adapt research studi eight candid refer gene sulfit oxidas suox victorin bind protein vbp actin encod actin protein psk simul like psks tata bind protein like tbp ubiquitin conjug enzym e ubc elong factor alpha ef glyceraldehyd phosphat dehydrogenas gapdh select base previous studi oat transcriptom data express stabil refer gene oat root stem leav uv b high light stress first calcul use three frequent use statist softwar genorm normfind bestkeep comprehens stabil gene evalu use reffind result show stabli express refer gene root stem leav oat uv b stress ef tbp psks respect stabli express refer gene root stem leav high light stress psks ubc psks respect psks stabli express refer gene sampl reliabl select refer gene valid analysi express phenylalanin ammonia lyas pal gene studi highlight refer gene accur quantit analysi gene express differ tissu oat uv b high light stress | D018554;D020648 | T126;T123;T116;T002 |
36,232,487 | develop novel primer taqman probe set diagnosi quantif meloidogyn enterolobii soil use qpcr droplet digit pcr assay earli detect pathogen plant season valuabl forecast diseas occurr therefor rapid reliabl diagnost approach urgent need especi one aggress root knot nematod meloidogyn enterolobii studi develop novel primer taqman probe set aim enterolobii primer probe set success appli identif quantif enterolobii via qpcr technolog also suitabl improv pcr technolog known ddpcr analys work present first applic technolog plant parasit nematod compar qpcr ddpcr exhibit better perform regard analyt sensit provid accur detect enterolobii conceal field soil addit generat standard curv calcul number egg soil use qpcr ddpcr platform hope result herein help forecast diseas sever enterolobii infect adopt effect manag strategi | D010271;D017187;D014431 | T204 |
36,232,486 | assess efficaci safeti use ppar agonist load nanocarri inflammatori eye diseas drug load nanocarri ncs new system great improv deliveri target drug specif tissu organ work ppar agonist load polymer ncs prepar stabil spray dri test vitro ex vivo vivo anim model provid safe formul optic anti inflammatori treatment ncs shown well toler sign irrit alter eye properti detect vitro het cam test vivo draiz test furthermor sign cytotox found nc formul retinoblastoma cell analyz use alamarblu assay transmitt experi evidenc good corneal transpar formul test ocular anti inflammatori studi confirm signific prevent efficaci use ncs system affect corneal tissu structur moreov anim corneal structur treat ncs analyz use x ray diffract use synchrotron light small angl x ray scatter sax analysi show signific differ corneal collagen interfibrillar space treatment fresh prepar ncs ncs dri process compar correspond negat control inflamm induc consid result ppar agonist ncs could safe effect altern treatment inflammatori ocular process | D005128;D047492 | T047;T116;T192 |
36,232,485 | integr analys regul mediat methyl modif pattern tumor microenviron infiltr character pan cancer invas immun cell tumor microenviron tme close relat cancer develop studi demonstr n methyladenosin affect invas immun cell tme well cancer develop comprehens analyz rna seq data differ cancer type base regul identifi two distinct modif pattern close associ tme cell infiltr overal patient surviv use princip compon analysi pca construct mascor base express relat prognost gene success predict patient surviv low mascor subtyp character immun cell infiltr good prognosi lower tnm stage high mascor subtyp character low immun infiltr stromal activ poor prognosi mascor also close associ immunotherapi respons signific higher complet responseparti respons crpr patient stabl diseaseprogress diseas sdpd patient immunotherapi cohort therefor studi indic modif play import role prognosi pan cancer format complex tme pan cancer research help improv cognit modif pan cancer level identifi effect strategi immunotherapi | D009369;D059016 | T191;T070 |
36,232,484 | analysi effect ninjinyoeito physic frailti mice physic frailti age relat clinic syndrom involv decreas bodi weight mobil activ walk speed occur individu sarcopenia acceler increas oxid stress ninjinyoeito tradit japanes kampo medicin use treat condit includ anemia physic weak investig whether ninjinyoeito could improv physic frailti control oxid stress senesc acceler mous prone samp model first samp mice divid two group ninjinyoeito treat untreat former consum diet contain ninjinyoeito month age month age bodi weight motor function locomotor activ mean walk speed measur subsequ mice euthan measur muscl weight hydroxi deoxyguanosin level muscl brain cleav caspas express brain result show reduct weight locomotor function locomot averag walk speed untreat group signific improv ninjinyoeito furthermor hydroxi deoxyguanosin level reduc muscl brain ninjinyoeito treat mice compar level untreat mice cleav caspas express similar reduc brain treat mice indic reduc apoptosi find suggest ninjinyoeito inhibit sarcopenia base physic frailti antioxid effect | D000073496;D055948 | T047;T046;T184;T033 |
36,232,483 | sensorineur hear loss sjgren syndrom sjgren syndrom chronic autoimmun diseas character system dysfunct exocrin gland main salivari lachrym gland sjgren syndrom consist two form primari sjgren syndrom character dri eye dri mouth without autoimmun diseas secondari sjgren syndrom character symptom associ autoimmun diseas system lupus erythematosus diseas sever vari consider mild glandular dryness sever glandular involv numer extraglandular system featur sensorineur hear loss sometim observ primari secondari sjgren syndrom review articl consist patholog sjgren syndrom clinic manifest sjgren syndrom autoimmun inner ear diseas histoanatom featur inner ear immunolog characterist inner ear pathophysiolog autoimmun inner ear diseas treatment sensorineur hear loss sjgren syndrom futur direct final introduc recent develop diseas model salivari gland inflamm discuss futur expect treatment sensorineur hear loss sjgren syndrom | D006319;D007638;D007759;D012859 | T047 |
36,232,482 | ch express crucial methyl jasmon induct chicor acid product echinacea purpurea l moench cell suspens cultur echinacea purpurea l moench one econom import medicin plant cultiv worldwid high medicin valu sever industri applic pharmaceut food industri thank various phytochem content includ caffeic acid deriv cad e purpurea extract antioxid anti inflammatori immuno stimul properti among cad chicor acid one import compound shown import pharmacolog properti present research aim optim product chicor acid e purpurea cell cultur methyl jasmon meja differ concentr differ durat treatment util elicitor content total polyphenol chicor acid measur sever gene involv chicor acid biosynthet pathway select express evalu differ time point cell cultur growth perform aim identifi suitabl putat molecular marker use proxi earli predict chicor acid content without need expens quantif method correl product chicor acid respons meja increas respons oxid stress also propos | D001688;D020900 | T121;T123;T002 |
36,232,481 | photosynthet reaction molecul function simpl model complex system photosynthesi basic process life earth one chang life histori drastic | D018534;D010788 | T044;T083;T039;T070 |
36,232,480 | emerg role ceramid breast cancer biolog therapi one classic hallmark cancer imbal elev cell prolifer reduc cell death ceramid bioactiv sphingolipid regul balanc long implic cancer effect ceramid cell death therapeut efficaci well establish emerg evid indic ceramid turnov downstream sphingolipid sphingomyelin hexosylceramid sphingosin phosphat ceramid phosphat equal import drive pro tumorigen phenotyp prolifer surviv migrat stem therapi resist complex dynam sphingolipid network extens studi sever cancer includ breast cancer find key sphingolipidom alter exploit develop new therapeut strategi improv patient outcom review current literatur shape understand ceramid synthesi turnov alter breast cancer chang offer potenti strategi improv breast cancer therapi | D009369;D013109 | T191;T109;T123 |
36,232,479 | disord glucos level associ xanthin oxidas activ overweight type diabet women oxid stress play import role vascular complic observ patient obes type diabet td xanthin oxidas xo break purin nucleotid uric acid contribut product reactiv oxygen speci ros howev relationship xo activ glucos homeostasi td subject obes unclear hypothes disord glucos level associ serum xo activ overweight women men td without hyperuricemia studi serum xo activ women men without td result show serum xo activ greater td patient bodi mass index bmi kgm bmi lt kgm p lt sex base compar analys overweight td patient show serum xo activ correl homeostasi model assess cell function homa fast plasma glucos fpg hemoglobin ac overweight td women overweight td men addit compar overweight td men women higher high sensit c reactiv protein hs crp level howev overweight td men higher xo activ uric acid level women result suggest xo activ higher overweight td patient especi men sensit disord glucos level overweight women td | D003924;D050177 | T047;T033 |
36,232,478 | metabol signal plant mitochondria adapt environment stress interact mitochondria cellular compon evolv differ plant mammal plant organell contain protein altern oxidas aox conjunct intern extern altern nad p h dehydrogenas allow canon oxid phosphoryl oxpho bypass plant mitochondria also contain uncoupl protein ucp bypass oxpho recent work reveal oxpho bypass perform aox ucp link new mechan mitochondri retrograd signal aox function associ apic meristem transcript factor mediat mitochondri retrograd signal ucp regul plant oxygen sens mechan via prt n degron discuss crosstalk independ action aox ucp mitochondri retrograd signal associ abiot stress respons also discuss mitochondri function retrograd signal mechan affect chloroplast function addit discuss mitochondri inner membran transport mediat mitochondri communic organell last review mitochondri metabol use improv crop resili environment stress respect particular focus contribut brazilian research group advanc topic mitochondri metabol signal | D024101;D009243 | T121;T123;T116;T114 |
36,232,477 | genotyp phenotyp landscap japanes patient tuber sclerosi complex tuber sclerosi complex tsc autosom domin disord character multipl dysplast organ lesion neuropsychiatr symptom caus loss function mutat either tsc tsc genotyp phenotyp analys conduct worldwid larg scale studi japanes patient still mani unclear point studi analyz japanes patient tsc definit possibl genet diagnos total mutat tsc tsc identifi mosaic mutat larg intragen delet four splice abnorm due deep intron mutat sever lesion symptom differ preval sever tsc tsc patient general sever tsc patient moreov tsc missens frame mutat may attenu skin renal symptom compar tsc mutat genet test reveal approxim parent proband mild tsc could miss patient demograph present studi reveal high frequenc tsc patient low preval epilepsi compar global statist patient mild neuropsychiatr phenotyp diagnos japan seem due higher util brain imag suggest possibl signific amount mild tsc patient may correct diagnos worldwid | D014402 | T191 |
36,232,476 | cardiac alarmin residu risk marker atherosclerosi hypolipidem therapi increas level low densiti lipoprotein main risk factor initi progress atherosclerosi although statin treatment effect lower level still residu risk cardiovascular event hypothes specif panel stress sens molecul alarmin could indic persist silent atherosclerosi residu risk new zealand white rabbit divid control group c group receiv high fat diet twelv week au treat hyperlipidem group lipid diet eight week follow standard diet hypolipidem treatment atorvastatin pcsk sirna inhibitor four week asi mass spectrometri experi left ventricl lysat complement immunolog genom studi corrobor data hyperlipidem diet determin general alarmin regul tendenc c group signific spectral abund increas measur specif heat shock protein famili member hmgb annexin hypolipidem treatment demonstr revers regul trend non signific spectral alter c group identifi alarmin studi highlight discrimin potenti alarmin hyperlipidemia follow hypolipidem treatment data avail via proteomexchang identifi pxd | D017305;D050197;D024243;D019161 | T047;T046;T116;T121;T109;T123 |
36,232,475 | synthesi anticanc activ molecular dock studi novel n mannich base oxadiazol base dimethylpyridin scaffold cancer one greatest challeng modern medicin today difficult long term treatment mani side effect drug use grow resist treatment neoplast cell necessit new approach therapi promis target therapi base direct impact cancer cell continu research new biolog activ molecul report herein design synthesi anticanc evalu new seri n mannich base type hybrid compound contain morfolin differ substitut piperazin moieti oxadiazol ring dimethylpyridin core compound test potenti cytotox five human cancer cell line c snb mcf wt mcf dx two activ n mannich base compound evalu growth inhibit effect melanoma c normal hacat cell line use clonogen assay popul doubl time test apoptosi determin neutral version comet assay confoc microscopi method enabl visual f actin reorgan obtain result demonstr compound cytotox proapoptot effect melanoma cell capabl induc f actin depolar dose depend manner moreov comput chemistri approach molecular dock electrostat potenti employ studi non coval interact investig compound four receptor found examin molecul exhibit similar bind affin respect chosen refer drug | D000970;D008545 | T121;T109;T191 |
36,232,474 | studi phytochem profil ocimum basilicum var minimum l alef essenti oil larvicid activ silico interact acetylcholinesteras aed aegypti diptera culicida aed aegypti l diptera culicida import transmitt diseas tropic countri control larva mosquito help reduc case diseas dengu zika chikungunya thus present studi aim evalu larvicid potenti essenti oil eo ocimum basilicum var minimum l alef eo extract stem distil chemic composit character gas chromatographi coupl mass spectrometri gcms gc fid larvicid activ eo evalu third instar ae aegypti follow world health organ standard protocol interact major compound acetylcholinesteras ach evalu molecular dock predomin class oxygen monoterpen concentr major compound limonen cineol linalool methyl chavicol basilicum var minimum eo show unpreced activ third instar ae aegypti larva dose depend relationship lc gml lc gml major compound abl interact ach molecular dock assay indic ecolog altern mosquito larva control | D000330;D007306;D018649;D009822;D000071244;D000071243 | T047;T002;T131;T109;T005;T204 |
36,232,473 | urin nmr metabolom precis oncolog colorect cancer metabolom fundament approach discov novel biomark potenti use precis medicin appli popul screen nmr base metabolom becom power clinic tool precis oncolog urin test wide accept due intrins non invas review provid first exhaust evalu nmr metabolom determin colorect cancer crc urin specif search pubm web scienc scopus perform studi met requir criteria restrict queri studi type lead colorect cancer sampl versus control comparison also prospect studi surgic effect review compound includ studi merg databas identifi compound urin sampl found least three articl result analyz three group case crc adenoma control pre post surgeri combin group combin case control pre post surgeri group twelv compound found relev seven regul metabolit crc identifi creatinin hydroxybenzo acid aceton carnitin glucos hippur acid l lysin l threonin pyruv acid three regul compound crc identifi acet acid phenylacetylglutamin urea pathway enrich analysi return two pathway signific express pyruv metabol glycolysisgluconeogenesi pathway case pyruv acid regul urin crc patient cancer cell prolifer effect tissu acet acid regul urin crc patient chemoprotect effect present | D015179;D019289 | T191;T109;T123;T121 |
36,232,472 | mpsi manifest treatment outcom skelet focus mucopolysaccharidosi type mpsi omim autosom recess disord caus pathogen variant idua gene encod lysosom alpha l iduronidas enzym defici enzym caus system accumul glycosaminoglycan gag although diseas manifest typic appar birth present earli life progress includ wide spectrum phenotyp find among storag gag within lysosom disrupt cell function metabol cartilag thus impair normal bone develop ossif skelet manifest mpsi often refractori treatment sever affect patient qualiti life review discuss patholog molecular process lead impair endochondr ossif mpsi patient limit current therapeut approach understand under mechan respons skelet phenotyp mpsi patient crucial could lead develop new therapeut strategi target skelet abnorm mpsi earli stage diseas | D007068;D008059 | T047;T126;T116 |
36,232,471 | lipopolysaccharid cellular senesc involv atherosclerosi atherosclerosi chronic inflammatori diseas vascular wall relat age thus far role cellular senesc bacteri infect pathogenesi atherosclerosi specul independ type macrophag vascular endotheli cell vascular smooth muscl cell senesc state site atherosclerot lesion likewis bacteri infect accumul lipopolysaccharid lps outer membran compon gram negat bacteria also observ atherosclerot lesion patient review introduc integr two potenti pathway atherosclerosi previous studi suggest lps direct induc cellular senesc cultur monocytesmacrophag vascular cell addit lps enhanc inflammatori properti senesc associ secretori phenotyp sasp senesc endotheli cell thus lps deriv gram negat bacteria could exagger pathogenesi atherosclerosi induc enhanc cellular senesc sasp associ inflammatori properti specif vascular cell atherosclerot lesion propos mechan provid novel approach prevent treat common age relat diseas | D050197;D008070 | T047;T046;T109 |
36,232,470 | take breather advanc interleukin inhibit asthma relief interleukin il major cytokin respons eosinophil prolifer migrat degranul eosinophil play consider role manifest type asthma therefor make il uniqu clinic import target therapeut intervent due critic role il play area eosinophil activ identifi target three therapeut mepolizumab benralizumab reslizumab review describ il pathway present clinic trial histori three il inhibitor provid insight role il clinic asthma present addit review aim foster investig il pathway describ current novel therapeut discoveri strategi monoclon antibodi | D018927;D001249 | T121;T047 |
36,232,469 | anti tnf therapi suppress adipos tissu inflamm crohn diseas anti tnf biolog shown mark improv qualiti life patient crohn diseas cd yet one third patient fail benefit treatment patient cd develop characterist wrap viscer adipos tissu vat inflam intestin area term creep fat known adipos tissu expans influenc efficaci anti tnf drug question whether anti tnf therapi impact creep fat cd might affect outcom diseas adipos tissu biopsi obtain cohort patient cd receiv anti tnf drug non anti tnf treat patient control group match sex age bodi mass index undergo surgic intervent symptomat complic found anti tnf therapi restor adipos tissu morpholog suppress immun cell infiltr creep fat addit anti tnf treatment appear mark improv pro inflammatori phenotyp adipos tissu macrophag adipos tissu deriv stem cell studi provid evid anti tnf medic influenc immun cell progenitor cell creep patient cd suppress inflamm propos perilesion vat consid administ anti tnf therapi patient cd | D001688;D003424 | T121;T047;T123 |
36,232,468 | strategi convert cell hyalin cartilag magic spell adult stem cell damag hyalin cartilag gradual decreas joint function grow pain signific reduc qualiti patient life clinic approv procedur autolog chondrocyt implant aci treat knee cartilag lesion sever limit includ absenc healthi articular cartilag tissu cell isol difficulti relat chondrocyt expans vitro today various aci modif develop use autolog chondrocyt altern sourc auricl nose rib adult stem cell differ tissu also great interest due less traumat materi extract innat abil activ prolifer chondrogen differenti accord differ adult stem cell type origin various strategi propos stem cell expans initi chondrogen differenti current review present divers develop appli techniqu base autolog adult stem cell differenti hyalin cartilag tissu target articular cartilag damag therapi | D053687;D002358 | T025;T024 |
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