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36,231,162 | drink expect among chines young adult qualit studi hong kong alcohol expect ie perceiv consequ drink report import factor predict drink behavior howev studi asia region larg limit school base sampl studi aim first explor drink expect among urban chines young adult | D000428;D044466 | T098;T055 |
36,231,161 | high urban rural inequ abdomin obes malawi insight malawi noncommunic diseas risk factor survey geograph dispar abdomin obes ao exist low incom countri due major demograph structur chang urban rural area aim investig differ urban rural preval ao malawi popul conduct secondari analysi data malawi step survey ao primari outcom high waist circumfer secondari outcom defin use criteria preval estim ao high waist circumfer wc standard age sex use age sex structur adult popul malawi provid census modifi poisson regress analysi adjust sociodemograph covari perform compar outcom two group urban versus rural total adult adult age includ studi age sex standard preval ao higher urban rural area vs adjust preval ratio apr confid interv ci p lt signific trend close gap urban rural apr ci p lt urban rural gap remain slight wider consid high wc threshold vs apr ci p lt vs apr ci p lt signific urban rural differ exist preval ao high wc malawi gap improv last eight year effect weight manag strategi promot reduc health care dispar malawi particular urban area | D000073296;D056128 | T047;T184;T033 |
36,231,160 | poor eat behavior relat progress prediabet japanes popul open cohort studi studi aim examin lifestyl factor associ chang glucos categori among individu without diabet analyz cohort data medic check up baselin april decemb primari secondari outcom chang glucos categori normoglycemia glycat hemoglobin hbac lt fast plasma glucos fpg lt mmoll prediabet hbac fpg mmoll prediabet normoglycemia mean follow year individu normoglycemia develop prediabet wherea individu prediabet return normoglycemia factor associ progress prediabet baselin bmi hazard ratio confid interv chang bmi follow late dinnersnack skip breakfast heavi alcohol consumpt factor associ return normoglycemia prediabet baselin bmi chang bmi follow conclus poor eat behavior skip breakfast late dinnersnack heavi alcohol consumpt associ progress normoglycemia prediabet | D011236 | T047 |
36,231,159 | evalu common prosper level region differ analysi along yangtz river econom belt common prosper essenti requir social well common aspir social peopl articl construct evalu index system indic common prosper cover four dimens materi wealth harmoni social life rich spiritu life livabl ecolog environ topsi method use comprehens rank nine provinc two municip yangtz river econom belt result show level common prosper along yangtz river econom belt increas signific level common prosper lower reach yangtz river econom belt much higher middl upper reach accord differ common prosper level among region provinc citi divid three categori high unbalanc low combin characterist type region polici suggest put forward perspect strengthen region industri cooper mechan deepen construct region livelihood infrastructur basic public servic improv abil region environment coordin | D007221;D045483 | T078;T057;T070 |
36,231,158 | structur relationship physic activ psychosoci function women men covid epidem poland sinc coronavirus diseas covid pandem serious crisi mani countri around world import conduct empir research aim identifi risk factor protect function peopl affect reason goal present research determin level physic activ sever symptom characterist mental disord cognit disord qualiti social function well structur relationship physic activ psychosoci function women men covid epidem eastern poland research conduct use ipaq sf questionnair ghq questionnair tus test version origin sfs scale self develop sociodemograph survey collect data indic women compar men show lower level week physic activ walk moder activ vigor activ qualiti function famili relationship higher sever mental health disord somat symptom function disord depress symptom cognit disord perceptu work disord attent deficit higher qualiti function work relationship hand structur model indic physic activ interact mental health disord cognit disord posit associ social function respond gender moder occur depend suggest physic activ adapt condit health may import compon gender individu psychoprevent intervent | D000086382 | T047;T067 |
36,231,157 | shoulder disloc incid risk factor rural vs urban popul poland background aim studi analyz incid shoulder disloc estim non modifi risk factor rural urban subgroup poland method studi cover entir polish popul divid urban rural subgroup observ januari decemb studi popul consist polish patient diagnosi shoulder disloc accord intern statist classif diseas relat health problem icd record obtain public health care provid nation health found narodowi fundusz zdrowia nfz base data assess shoulder disloc incid risk rate stratifi studi sampl sex age place resid rural urban use central statist offic gus person territori code teryt incid person year rural area person year urban area find signific differ incid two subgroup highest incid person year highest risk shoulder disloc found among subject year old live urban area furthermor men third decad life live urban area show highest risk ci p lt subgroup likelihood shoulder disloc signific lower femal sex among children year old howev girl live rural area present signific higher likelihood disloc compar peer live urban environ conclus signific differ incid rate shoulder disloc polish resid live rural urban area emerg highest incid observ among femal subject year old live urban environ highest risk found among men third decad life live urban area addit girl first decad life live rural area shoulder disloc girl live urban environ shoulder disloc domin femal subject age live rural area femal year old live urban area | D012783 | T047;T037 |
36,231,156 | empow elementari middl school youth speak safe advanc prevent child maltreat univers school base curriculum child maltreat global public health problem school base univers prevent program speak safe sub curriculum effect solut help address child violenc random control studi employ pre post six month follow design student kindergarten grade approxim age n survey measur efficaci curriculum increas student knowledg safeti rule self protect strategi analys explor differ follow condit indexscal grade use analysi covari control pre survey score sub group signific higher score follow student control group studi show student learn new knowledg skill act upon identifi child abus neglect keep other safe polici decis maker know child maltreat prevent program sub implement univers school low cost deliv essenti evid base safeti curriculum protect student child maltreat | D002649;D012574 | T092;T073;T048 |
36,231,155 | feasibl intervent simpl exercis risk fall dementia patient pilot studi physic exercis help older peopl maintain capac muscl strength balanc postur control bone mass function adl usual declin age dementia patient attend day care center particip activ cognit train music art therapi physic exercis session research aim determin effect simpl lower limb strength singl leg stanc train feasibl facil day care center reduc risk fall elder dementia twenti patient dementia divid intervent control group particip mobil strength coordin balanc exercis session min weekday week addit intervent group patient perform simpl lower limb strength sit stand singl leg stanc exercis everi session risk fall assess tinetti test sppb comparison post pre intervent score tinetti test sppb statist increas p point p intervent patient simpl lower limb strength singl leg stanc exercis feasibl done day care facil effect tool reduc risk fall elder dementia | D000058;D003704 | T048;T037 |
36,231,154 | internet websit portray herbal vital product contain eurycoma longifolia jack evalu qualiti risk onlin inform tongkat ali ta eurycoma longifolia herbal medicin hm plant tradit use treat sexual dysfunct enhanc libido men websit contain inform hm abund howev studi shown general qualiti websit contain inform hm low present studi aim assess qualiti risk websit contain inform ta supplement identifi health claim ta | D035701 | T002 |
36,231,153 | organ level factor associ chang deliveri five smoke cessat follow implement comprehens tobacco free workplac program within substanc use treatment center mani adult substanc use disord smoke cigarett howev tobacco use common address substanc use treatment center studi examin provid belief address tobacco use non nicotin substanc use treatment provid self efficaci deliv tobacco use assess perceiv barrier routin provis tobacco care associ chang deliveri evid base five smoke intervent ask advis assess assist arrang organiz level data substanc use treatment center implement tobacco free workplac program data collect program implement linear regress examin center level averag provid factor pre implement post minus pre implement associ chang use five smoke substanc use treatment patient result indic center provid endors less agreement tobacco use address non nicotin substanc use treatment report lower self efficaci provid tobacco use assess pre implement associ signific increas ask patient smoke assess interest quit assist quit attempt post implement center report barrier pre implement center greater reduct report barrier treatment time greater increas assess patient interest quit smoke assist quit attempt post implement overal center learn regard address patient tobacco use greater chang use five compar center whose personnel alreadi better inform train find studi advanc implement scienc contribut inform relev reduc research practic translat gap tobacco control patient group suffer tobacco relat health dispar | D016540;D019966 | T055;T048;T033 |
36,231,152 | effect acut ashwagandha ingest cognit function ashwagandha withania somnifera report decreas percept stress enhanc mood improv cognit function howev current unknown whether acut ashwagandha supplement affect memori cognit function studi evalu effect acut ashwagandha extract ingest execut function | D032341 | T002 |
36,231,151 | chang mental health three wave covid pandem slovakia neurotyp children versus children autism spectrum disord parent main goal research monitor chang mental health slovak famili children autism spectrum disord asd compar famili neurotyp children three wave covid pandem focus preval depress anxieti stress differ stressor parent children explor maladapt behavior avail intervent children asd data collect use extens questionnair includ depress anxieti stress scale questionnair dass two subscal vineland adapt behavior scale vab research sampl consist total parent child asd parent children asd report elev anxieti first wave chang found parent neurotyp children second wave preval anxieti depress stress experienc parent group increas signific parent asd children intern maladapt behavior children asd also increas third wave signific differ group parent found stress anxieti parent asd children score higher depress extern maladapt behavior neurotyp children increas minim chang children asd explain improv therapi avail children asd also observ studi | D000067877;D000086382 | T047;T067;T048 |
36,231,150 | breastfeed communiti vulner resili disast snapshot unit state gulf coast climat chang induc disast increas intens frequenc unit state infant feed aftermath extrem event particular challeng especi given larg variat communiti vulner resili aim studi identifi physic social spatial vulner communiti along gulf coast highlight locat high low breastfeed initi rate potenti offset exacerb infant feed challeng wake disast structur studi retrospect spatial data analysi breastfeed initi risk extrem event social vulner communiti resili uncov locat may need post disast intervent result suggest signific gap geograph distribut communiti risk vulner resili breastfeed initi exist mani metropolitan area benefit high breastfeed initi rate also risk disast convers mani rural communiti face less risk extrem event exhibit social vulner less resili disast strike priorit emerg respons resourc support infant feed disast critic import urban rural communiti diverg profil requir variabl strategi ensur recoveri result highlight variabl provid prescript guidanc regard potenti alloc emerg resourc | D004189;D004190 | T064;T067;T052 |
36,231,149 | polycycl aromat hydrocarbon indoor dust croatia level sourc human health risk compound contribut indoor pollut regular investig due fact peopl spend time indoor worldwid investig shown polycycl aromat hydrocarbon pah present indoor dust best knowledg paper report first time presenc pah croatian household eleven pah analys hous dust sampl collect citi zagreb surround n possibl indoor sourc associ health risk assess total mass fraction detect pah rang ng g ng g median ng g wherebi four ring compound flu pyr contribut daha compound show statist signific posit correl analys pah indic origin differ sourc base diagnost ratio princip compon analysi pca mix sourc contribut pah level present croatian household although result indic croatian hous dust weak pollut pah total ilcr valu calcul children adult reveal peopl expos highest mass fraction pah measur area elev cancer risk | D000393;D009369;D011084 | T191;T109;T131 |
36,231,148 | natur base resili experi five citi south asia mani part world urban area south asian region increas expand citi today heart commerci technolog social develop also vulner varieti natur anthropogen threat complex urban infrastructur ever expand popul citi exacerb impact climat chang increas risk natur hazard throughout histori various hydrolog disast includ flood tidal surg drought non hydrolog disast earthquak landslid storm led catastroph social econom environment impact numer south asian citi disast risk reduct therefor central ensur sustain urban area although natur base solut nbs identifi promis strategi reduc risk increas resili appear lack evid base approach nbs measur practic obtain benefit natur environment communiti develop conserv manag restor ecosystem backdrop south asian citi provid opportun evalu capac achiev natur base resili nbr nbs studi document insight five citi five differ countri south asian region subject wide array disast barish bangladesh phuentshol bhutan gurugram india kathmandu nepal colombo sri lanka primari object studi provid evid nbs practic thus success stori citi consider highlight restor natur canal integr develop plan communiti particip barish concept gross nation happi gnh minim natur intervent phuentshol green citi includ eco corridor veget belt biodivers park gurugram proper land use plan aim differ disast kathmandu wetland restor manag multipl benefit colombo case could therefor act proxi learn prepar recov futur disast build nbr | D004190;D017753 | T082;T067;T070 |
36,231,147 | systemat review water sanit hygien urban poor low middl incom countri covid pandem gender len inadequ water sanit hygien wash among urban poor women major urban polici concern low middl incom countri lmic pauciti systemat inform wash among urban poor pandem review opportun challeng face urban poor lmic covid pandem use prisma guidelin conduct comprehens search databas includ medlin embas web scienc cinahl novemb august use themat analysi synthes qualit data meta analys estim pool preval screen record conduct full text review studi includ studi pool preval share water point ci non adher hygien practic ci non adher face mask ci access share communiti toilet ci insuffici facil caus crowd long wait time share facil make physic distanc challeng women report difficulti maintain privaci sanit men present due stay home rule due unafford women report use cloth instead sanitari pad scarv instead mask | D000086382;D012499 | T090;T047;T067 |
36,231,146 | systemat review meta analysi mercuri exposur among popul environ contact electron wast electron wast e wast recycl releas mercuri hg environ though knowledg hg level site yet examin worldwid basi systemat review scientif studi conduct extract analyz synthes data hg level e wast product environ near recycl site peopl data extract studi countri includ hg level electr electron product environment sampl soil air plant food water dust human biomark blood hair urin averag hg level product gg highest level found lamp gg averag soil sediment hg level gg e wast site least eight time higher control site averag urinari hg level gg creatinin approxim two fold higher among e wast worker versus control group collect find demonstr e wast recycl may lead hg contamin environ human popul close proxim process site find contribut grow knowledg base mercuri exposur divers sourc exposur pathway work potenti polici implic context minamata convent | D059029;D008628 | T068;T131;T196 |
36,231,145 | plan sustain green urban empir bottom communiti led perspect green infrastructur gi indic khyber pakhtunkhwa kp pakistan rise vulner urban green infrastructur ugi grab global attent inclus urban landscap green polici ulgp framework crucial support green growth research intend explor local communiti perspect assembl sustain ugi indic vital taxonomi urban green space ug element aim develop multi function sustain ugi indic base framework eco friend support green resili citi khyber pakhtunkhwa kp provinc pakistan depth household survey execut three kp district charsadda peshawar mardan place self administ questionnair cover theme around climat chang adapt urban resili ugi relat import index rii interquartil rang iqr method set data analysi reveal excel reliabl gt intern consist result confirm communiti base ugi indic focus promot green energi save strategi e imp level rii ten ugi indic import rii eleven moder import rii ugi indic found enhanc ug element rii find provid foundat urban polici chang develop sustain ugi framework build eco region paradigm greener growth | D057231;D007291 | T121;T123;T114;T070 |
36,231,144 | social infrastructur street network critic infrastructur age friend communiti design mediat effect physic activ establish age friend environ communiti level essenti promot healthi age studi focus relationship older adult communiti environ level satisfact within measur physic activ pa communiti environ three variabl communiti level satisfact communiti environ sce communiti social infrastructur ssi communiti street network ssn analyz older adult particip suzhou use mediat analysi multipl linear regress investig relationship physic activ communiti environ result mediat effect model show sce ssi ssn affect physic function older adult via total amount physic activ tpa ssi ssn affect older adult physic function affect total durat moder intens physic activ mpa vigor intens physic activ vpa addit ssi ssn relat type communiti facil street space qualiti access studi provid valuabl insight optim age friend neighborhood moder vigor intens pas facil street space level | D066270 | T169;T078 |
36,231,143 | meg express indic lymph node metastasi presenc cancer associ fibroblast papillari thyroid cancer papillari thyroid cancer common endocrin malign occur incid rate per us adult popul overal year surviv ptc near presenc lymph node metastasi lnm capsular invas indic need extens neck dissect possibl adjuv radioact iodin therapi imag modal ultrasound ct current use detect suspici cervic lymph node sensit tumor posit node low therefor advanc preoper detect lnm may optim surgic medic manag patient thyroid cancer end analyz bulk rna sequenc dataset identifi candid marker high predict lnm identifi meg long noncod rna previous describ tumor suppressor express malign cell high associ lnm tissu furthermor express meg high predict tumor infiltr cancer associ fibroblast singl cell rna sequenc data reveal express meg isol cancer associ fibroblast caf aggress form thyroid cancer find suggest meg express specif caf high associ lnm may driver aggress diseas | D000072645;D002291;D013964 | T191;T025 |
36,231,142 | patient select approach fgfr inhibitor trial mani path end inhibitor fibroblast growth factor receptor fgfr signal investig various human cancer diseas recent first compound receiv fda approv biomark select patient popul differ approach technolog appli clinic trial rang protein immunohistochemistri mrna express eg rna situ hybrid detect various dna alter eg copi number variat mutat gene fusion review advantag limit differ technolog discuss import tissu diseas context identifi best predict biomark fgfr target therapi | D056915;D047428 | T121;T045;T116;T086 |
36,231,141 | rock inhibitor abolish negat impact mir endometrium deriv extracellular vesicl support embryo attach extracellular vesicl ev nanos vesicl act snapshot cellular compon mediat cellular communic may contain cargo content undesir effect develop model improv effect endometrium deriv ev endo ev porcin embryo attach feeder free cultur condit endo ev cargo content analyz use convent real time pcr micro rnas messeng rnas proteom porcin embryo generat parthenogenet electr activ feeder free cultur condit supplement without endo ev cellular uptak endo ev confirm use lipophil dye pkh endo ev cargo contain mir mir mir togeth mrnas porcin endogen retrovirus perv catenin target perv crisprca result reduc express perv mrna transcript increas mir endo ev supplement embryo reduc embryo attach supplement medium contain endo ev mir inhibitor signific improv embryo attach outgrowth supplement rho kinas inhibitor ri dramat improv embryo attach outgrowth moreov express mir mir mrna transcript bcl zinc finger e box bind homeobox catenin interferon protein tyrosin phosphatas non receptor type perv cyclin depend kinas increas embryo supplement endo ev ri compar control group endo ev ri reduc apoptosi increas express oct cdx cell number embryon outgrowth examin individu combin effect ri compar mir mimic found ri allevi negat effect mir mimic embryo attach outgrowth ev improv embryo attach unwant effect de trop cargo content mir allevi anti apoptot molecul rock inhibitor | D000067128;D035683 | T026;T123;T114 |
36,231,140 | mitochondri distress methylmalon acidemia novel pathogen insight therapeut perspect mitochondria high dynam doubl membran enclos organell sustain cellular metabol henc cellular organism homeostasi dysregul mitochondri network might therefor confer potenti devast vulner high energi requir cell type contribut broad varieti hereditari acquir diseas includ inborn error metabol cancer neurodegener age associ advers review highlight biolog function mitochondria local enzym perspect understand pathophysiolog inherit disord destroy mitochondri homeostasi cellular metabol use methylmalon acidemia mma paradigm mitochondri dysfunct discuss mitochondri direct signal pathway sustain physiolog homeostasi special cell type may disturb diseas condit review also provid critic analysi molecular underpin defect autophagi mediat qualiti control surveil system contribut cellular dysfunct indic potenti therapeut strategi affect tissu insight might ultim advanc discoveri develop new therapeut methylmalon acidemia also current intract mitochondri diseas thus transform abil modul health homeostasi | D000592;D028361 | T047 |
36,231,139 | ethylen activ ein ein eil signal pathway tapetum disturb anther develop arabidopsi ethylen previous report repress stamen develop cucumb arabidopsi perform detail analysi effect ethylen anther develop ethylen treatment stamen pistil display obvious development defect lead steril tapetum microspor microsporocyt degener ethylen treatment ein ein eil mutant ethylen treatment affect fertil indic effect ethylen anther develop mediat ein ein eil vivo transcript ein ein activ ethylen tapetum layer howev ectop express ein tapetum induc signific anther defect impli express ein regul post transcript level consist ethylen treatment induc accumul ein tapet cell thus ethylen activ transcript ein ein also stabil ein tapetum disturb develop express sever ethylen relat gene signific increas express five key transcript factor requir tapetum develop decreas ethylen treatment result thus point ethylen inhibit anther develop ein ein eil signal pathway activ signal pathway anther wall especi tapetum induc degener tapetum lead pollen abort | D017360;D029681 | T116;T002 |
36,231,138 | inflammatori signatur predict clinic benefit first line cetuximab plus platinum base chemotherapi recurrentmetastat head neck cancer epiderm growth factor receptor egfr pathway shown play crucial role sever inflammatori condit host immun inflamm status relat tumor prognosi studi aim evalu prognost signific four gene inflammatori signatur recurrentmetastat rm head neck squamous cell carcinoma hnscc patient treat egfr inhibitor cetuximab plus chemotherapi inflammatori signatur assess rm hnscc patient enrol multicent trial b receiv first line cetuximab plus platinum base chemotherapi primari endpoint studi progress free surviv pfs secondari endpoint overal surviv os object respons rate orr patient popul subdivid group accord signatur score group four gene signatur prove signific prognost valu result median pfs month patient high vs month intermedi vs month low valu p find confirm os median time month high intermedi low valu score respect p orr consid signatur signific higher respond non respond p reach area curv auc ci find highlight role inflamm respons cetuximab chemotherapi rm hnscc may translat implic improv treatment select | D006258;D010984 | T191;T196 |
36,231,137 | kras gd mutat subtyp pancreat ductal adenocarcinoma influenc prognosi stage diseas present background kras gd mutat subtyp present pancreat ductal adenocarcinoma pdac one lead global caus cancer death retrospect cohort studi aim investig whether detect kras gd mutat subtyp pdac patient determin prognosi across stage diseas method review medic record patient present pdac larg tertiari hospit compar surviv use kaplan meier log rank test cox proport hazard regress model result kras gd mutat subtyp signific associ poorer surviv compar across whole popul pdac patient p hr ci howev kras gd patient resect shorter median surviv time day compar genotyp median surviv day p hr ci conclus kras gd patient resect diagnosi shorter surviv compar pdac patient data suggest kras gd may clinic use prognost biomark pdac | D021441;D010190 | T191 |
36,231,136 | mitochondri vdac potenti therapeut target inflamm relat diseas clinic opportun multifunct protein voltag depend anion channel vdac locat mitochondri outer membran pivot protein maintain mitochondri function power cellular bioactiv via energi generat vdac involv regul energi product mitochondri oxidas stress ca transport substanc metabol apoptosi mitochondri autophagi mitophagi mani function vdac malfunct associ mitochondri disord affect inflammatori respons result regul bodi defens respons stress stimul overrespons inflamm may caus chronic diseas mitochondri dna mtdna act danger signal trigger nativ immun system activ secret vdac mediat releas mtdna cytoplasm enhanc cytokin level activ immun respons vdac regul mitochondri ca transport lipid metabol mitophagi involv inflamm relat diseas pathogenesi mani scientist suggest approach deal inflamm overrespons issu via specif target therapi due broad function vdac may becom use target therapi inflamm relat diseas mechan vdac role inflamm requir explor comprehens systemat summar role vdac inflammatori respons hope research lead novel therapeut strategi target vdac order treat inflamm relat disord | D008928;D050995 | T043;T026;T123;T116 |
36,231,135 | captopril allevi chondrocyt senesc doca salt hypertens rat associ gut microbiom alter gut microbiota key control healthi age hypertens osteoarthr oa two frequent co exist age relat patholog older adult associ gut microbiota dysbiosi herebi explor gut microbiom alter deoxycorticosteron acet doca induc hypertens rat model captopril anti hypertens medicin chosen attenu joint damag knee joint harvest radiolog histolog examin meanwhil fecal sampl collect rrna shotgun sequenc rrna data annot use qiim v metagenom data function profil humann databas differenti abund analys adopt identifi signific bacteri genera pathway gut microbiota doca induc hypertens induc pinka senesc cell sncs accumul aorta kidney p lt also knee joint contribut articular cartilag degrad subchondr bone disturb captopril remov pinka sncs differ organ partial lower blood pressur mitig cartilag damag meanwhil alter found associ reduct escherichia shigella level gut microbiom gut microbiota dysbiosi might emerg metabol link chondrocyt senesc induc doca trigger hypertens under molecular mechan warrant investig | D064791;D000069196;D006973 | T047;T007;T121;T001;T109;T125 |
36,231,134 | extracellular matrix neuroblastoma cell communic complex interplay therapeut implic neuroblastoma nb pediatr neuroendocrin neoplasm aris sympatho adren lineag neural crest deriv multipot progenitor cell fail differenti nb common extracrani tumor children manifest undisput heterogen unsatisfactori outcom high risk hr nb patient call research inter relat treatment molecular featur diseas regard well establish tumor microenviron tme malign cell engag complex dynam interact extracellular matrix ecm stromal cell ecm sourc pro anti tumorigen factor regul tumor cell fate surviv prolifer resist therapi moreov ecm composit organ result signal network vast remodel tumor progress metastasi review main focus molecular mechan effect interact select ecm compon receptor neuroblastoma cell addit describ role enzym modifi degrad ecm nb final articl give exampl knowledg exploit prognosi yield new treatment option nb patient | D009447 | T191 |
36,231,133 | vitro transfect regul gene identifi favor outcom neuroblastoma cell line previous use microarray show high express dhrs nrob cypa predict favor nb outcom investig whether express gene associ suppress nb cell sk n sh nb tgw growth assess morpholog perform growth coloni format migrat assay well rna sequenc effect transient express gene also assess tetracyclin control express tet system gene overexpress reduc cell growth induc morpholog senesc gene express analysi identifi pathway involv cellular senesc cell adhes cell transduc gene dropout occur passag make long term stabl gene transfer difficult tet induc gene express caus pronounc cell morpholog chang specif dhrs nrob led rapid inhibit arrest cell growth though cypa affect cell growth rate cell cycl dhrs arrest cell cycl interact tran retinol pathway drove differenti senesc tumor overexpress gene reduc malign grade cell new therapeut strategi might induct gene suppress growth high risk neuroblastoma lead differenti senesc | D009447;D014801 | T191;T109;T127;T121 |
36,231,132 | model obes driven pancreat carcinogenesi review current vivo vitro model obes pancreat carcinogenesi pancreat ductal adenocarcinoma pdac common pancreat malign year surviv rate therebi exhibit worst prognosi solid tumor increas incid togeth continu lack target treatment option caus pdac second lead caus cancer relat death western world obes belong predomin risk factor pancreat cancer improv understand impact obes pancreat cancer develop progress novel laboratori techniqu develop review summar current vitro vivo model pdac obes well overview varieti model investig obes driven pancreat carcinogenesi start give overview differ method cultiv adipocyt vitro well various vivo mous model obes moreov establish murin human pdac cell line well organoid summar genet engin model pcac compar xenograft model introduc final review publish vitro vivo model studi impact obes pdac enabl us deciph molecular basi obes driven pancreat carcinogenesi | D021441;D010190 | T191 |
36,231,131 | flavon cirsiliol salvia x jamensi bind f moieti atp synthas modul free radic product sever studi shown mammalian retin rod outer segment os peculiar structur devoid mitochondria character ectop express molecular machineri oxid phosphoryl ectop aerob metabol would provid chemic energi phototransduct take place os natur polyphenol includ larg varieti molecul pleiotrop effect rang anti inflammatori antioxid other goal present studi investig potenti flavonoid cirsiliol trihydroxi dimethoxyflavon extract salvia x jamensi modul reactiv oxygen speci product ectop oxid phosphoryl take place os molecular dock analysi identifi cirsiliol bind site insid f moieti nanomotor f f atp synthas experiment approach base luminometri spectrophotometri cytofluorimetri evalu atp synthesi respiratori chain complex activ h product respect result show signific dose depend inhibit atp product cirsiliol moreov cirsiliol effect reduc free radic product os expos ambient light report consider protect effect cirsiliol structur stabil rod os suggest may consid promis compound oxid stress | D047309;D027544 | T109;T002 |
36,231,130 | air male fertil new hypothesi male infertil affect approxim european men character idiopath urgenc identifi factor affect male fertil one factor autoimmun regul air protein found thymus studi context central toler function nuclear transcript modul respons express tissu restrict antigen special thymic cell prevent autoimmun express test remain enigmat recent observ steril mice correl absenc air test regardless defici express medullari thymic epitheli cell cell hematopoiet system assess air transcript level discov sertoli cell exclus sourc air test like play non immun role suggest unknown mechan testicular air regul fertil discuss result context previous report suggest infertil observ air defici mice autoimmun aetiolog present altern point view role air test respect fertil alter perspect air function test current perceiv | D015551;D004847 | T025;T046 |
36,231,129 | cellular sourc neuroprotect role interleukin facial motor nucleus axotomi facial motoneuron fmn surviv mediat cd cell interleukin il depend manner facial nerv axotomi fna cd cell sourc neuroprotect il aim studi identifi tempor cell specif induct il express facial motor nucleus elucid neuroprotect capac express axotomi immunohistochemistri reveal fmn constitut produc il wherea astrocyt induc make il fna il mrna co local microglia axotomi microgli product il protein detect determin whether singl sourc il critic fmn surviv crelox mous strain util select knock il neuron astrocyt microglia agreement local data reflect concert il product multipl cell type singl cellular sourc il alon could provid neuroprotect fna find suggest coordin neuron astrocyt il product necessari fmn surviv role neuron homeostasi well neuroprotect trophism axotomi | D020220;D065828 | T023;T037 |
36,231,128 | dynam actin cytoskeleton signal pathway cellular wound repair repair wound cell membran essenti cell surviv upon wound actin transient accumul wound site loss actin accumul lead cell death mechan actin accumul wound site type actin relat protein particip actin remodel signal pathway unclear first examin actin accumul wound site dictyostelium cell actin assembl de novo wound site independ cortic flow next search actin signal relat protein target wound site fourteen examin protein transient accumul differ time third perform function analys use gene knockout mutant specif inhibitor rac wasp formin arp complex profilin coronin contribut actin dynam final found multipl signal pathway relat torc elmodoc complex pip deriv product pla calmodulin involv actin dynam wound repair | D000199;D004023 | T123;T116;T204 |
36,231,127 | investig two mode cancer associ antigen heterogen agent base model chimer antigen receptor cell therapi chimer antigen receptor car cell therapi success treat liquid tumor limit success solid tumor work examin unansw question regard car cell therapi use comput model percentag tumor must express cancer associ antigen treatment success model includ cancer cell vascular car cell modul interact compar two differ model antigen express tumor cell binari cancer cell either suscept immun car cell therapi gradat cancer cell probabl kill car cell vari antigen express level within tumor determin effect treatment two model simul show gradat antigen model elimin tumor paramet valu binari model model shield lownon antigen express cell protect high antigen express cell reduc efficaci car cell therapi one predict combin car cell therapi target general popul cell well one specif target cancer stem cell increas efficaci | D009369;D000076962 | T191;T192;T116;T129 |
36,231,126 | crosstalk extracellular matrix stiff ros drive endometri repair via hif yap axi menstruat although menstrual cycl driven sex steroid hormon uncompl physiolog process import femal health fertil regen biolog howev understand uniqu type tissu homeostasi remain unclear examin biolog effect mechan forc evalu chang trend extracellular matrix ecm stiff result suggest ecm stiff reduc break mechanotransduct delay endometrium repair mous model simul mens construct ecm stiff interfer model vitro explain mechan forc conduct mechan endometri regener discov ecm stiff increas express nuclear transfer yap improv creation microenviron manner induc prolifer angiogenesi endometri repair activ yap addit observ physiolog endometri hypoxia occur menstrual cycl express hif increas mechanist addit classic f actinyap pathway also found roshif yap axi involv transmiss mechan signal studi provid novel insight essenti menstrual cycl present effect nonhormon treatment menstrual disord | D040542;D008598 | T044;T040 |
36,231,125 | profound effect dexamethason immunolog state synthesi secret capac human testicular peritubular cell function human testicular peritubular cell htpcs form small compart locat seminifer epithelium interstiti area testi fulli known go beyond intratesticular sperm transport includ immunolog role express glucocorticoid receptor gr indic may regul glucocorticoid gcs herein studi consequ gc dexamethason dex cultur htpcs serv uniqu window human testi examin chang cytokin main qpcr elisa holist mass spectrometri base proteom analysi cellular secret protein also perform dex use therapeut concentr decreas transcript level proinflammatori cytokin eg il il mcp sirna mediat knockdown gr reduc action il chang il confirm elisa measur note dex also lower gr level proteom result reveal strong respons h signific alter cellular protein pronounc one h dex exposur less abund abund cellular protein dex also alter composit secretom protein decreas increas h among regul protein extracellular matrix ecm basement membran compon eg fbln cola cola well ptx star result pinpoint novel profound effect dex htpcs transferr human testi chang specif ecm immunolog state testi may occur men upon treatment dex medic reason | D012671;D013737 | T023 |
36,231,124 | multi transgener effect environment toxic mammalian reproduct environment toxic et exogen chemic group diffus environ contamin food water air soil food chain bioaccumul organ mammal exposur et affect male femal fertil reproduct health complex alter impact gametogenes among process human direct exposur et concur declin fertil transmiss across generat recent propos howev multi transgener inherit et reprotox demonstr anim review recent studi perform laboratori model anim investig effect et bpa phthalat pesticid persist contamin reproduct system transmit generat includ multigener effect exposur compound exclud transgener effect unexpos anim addit report epigenet mechan dna methyl histon tail noncod rnas may play mechanist role nongenet transmiss environment inform exposur germlin across generat | D006657;D010575 | T131;T123;T116 |
36,231,123 | patholog role hdac cancer beyond histon deacetylas hdac class hdac catalyz deacetyl histon non histon protein one best character isoform numer studi identifi interact partner hdac pertain divers molecular mechan consequ deregul overexpress hdac give rise diseas hdac especi involv various aspect cancer progress cancer cell prolifer metastasi immun evas drug resist hdac also associ develop non cancer diseas cornelia de lang syndrom cdls infecti diseas cardiovascular diseas pulmonari diseas myopathi therefor hdac attract therapeut target various hdac select inhibitor hdaci develop address patholog function hdac cancer diseas well illustr sever hdaci shown anti cancer effect | D003635;D009369 | T191;T047 |
36,231,122 | stereolog estim myocardi fat associ obes epicardi viscer adipos tissu normal human heart contain epicardi adipos tissu eat myocardi fat associ obes myocardi fat viscer adipos tissu vat cardiovascular diseas fulli understood object studi estim myocardi fat use stereolog method investig relat obes eat vat establish eat volum deceas individu includ postmortem comput tomographi conduct eviscer heart six sampl left right ventricl lv rv heart stereolog examin calcul percentag myocardi fat kidney oment fat weigh autopsi waist hip ratio calcul femal slight non signific p larger proport rv fat compar men found signific posit correl bodi mass index bmi lv myocardi fat p rv correl borderlin signific p eat volum posit correl rv lv myocardi fat found associ waist hip ratio whr oment kidney fat measur vat myocardi fat normal promin rv correl eat part bmi found associ vat | D050152;D009765 | T047;T024 |
36,231,121 | cell enrich lipotransf celt improv tissu regener rejuven without substanti manipul adipos tissu graft good avail larg content adult stem cell adipos tissu made one interest tissu regen medicin although lipofil one frequent procedur plastic surgeri method still struggl high absorpt rate volum loss therefor mani effort made optim liposuct process harvest tissu order increas fat graft retent immunomodulatori properti cytokin secretori activ differenti potenti enrich adipos tissu deriv stem cell identifi promis tool promot transplant surviv review import paramet lipofil optim final present new method enrich lipoaspir adipos tissu deriv stem cell discuss paramet contribut fat graft surviv | D015187;D012060 | T061 |
36,231,120 | mesenchym stemstrom cell therapeut tool cell base therapi regen medicin introduct expertis topic collect pleas present open editori introduc topic collect new era mesenchym stromalstem cell function applic state art therapeut challeng futur direct | D059630;D044968 | T025;T091 |
36,231,119 | calcium relat gene predict outcom serv therapeut target endometri cancer endometri cancer ec common gynecolog cancer increas incid dysregul intracellular calcium play crucial role cancer progress howev relationship calcium relat gene prognosi remain unclear studi aim establish risk model base calcium relat gene prognosi predict patient ec tcga total set divid train set test set four gene prognost signatur cacnad slca trpm ccl establish classifi ec patient low risk high risk group model valid test dataset total set ec patient high riskscor show signific shorter overal surviv low riskscor trend consist among subgroup moreov enrich analysi confirm calcium relat estrogen respons signal signific enrich high risk group knockdown cacnad sirna blocker amlodipin inhibit cell prolifer induc cycl arrest vitro calcium channel blocker inhibit cell prolifer induc cycl arrest vitro also show mark tumor inhibit effect vivo summari prognost model construct four calcium relat gene reliabl predict outcom ec patient calcium channel blocker signific potenti ec treatment | D002118;D016889 | T121;T191;T123;T196 |
36,231,118 | left atrial myocardium arteri hypertens arteri hypertens affect billion peopl worldwid associ increas morbid mortal respons million death year hypertens mediat damag target organ includ heart addit elicit left ventricular hypertrophi dysfunct heart failur hypertens also caus left atrial remodel may culmin atrial contractil dysfunct atrial fibril summar data various aspect left atrial remodel essenti hypertens gather studi patient hypertens spontan hypertens rat anim model close mimic cardiac remodel human hypertens analyz timelin remodel process ie distinguish alter occur prehypertens earli hypertens advanc hypertens heart diseas deriv potenti mechan under left atrial remodel essenti hypertens final discuss consequ remodel process atrial ventricular function data impli left atrial remodel multifactori start earli hypertens import contributor progress hypertens heart diseas includ develop atrial fibril heart failur | D001281;D064752;D006333;D006973 | T047;T046 |
36,231,117 | adhes g protein coupl receptor gpr adgrf regul epiderm differenti associ cytoskelet krt among human adhes g protein coupl receptor agpcr uniqu subfamili gpcrs adgrf encod gpr show obvious skin domin transcriptom profil express function skin larg unknown report gpr present small subset basal suprabas noncornifi keratinocyt stratifi epidermi support epiderm transcriptom data psoriat skin character hyperprolifer delay differenti express gpr krt fundament suprabas keratin dimer delay delet adgrf hacat keratinocyt grown organotyp mode abrog krt reduc keratinocyt stratif indic role gpr epiderm differenti unexpect endogen gpr glycosyl like proteolyt process local intracellular along krt posit keratin filament regular pattern data demonstr hitherto unknown function gpr regul epiderm differenti krt | D000078404;D015603 | T025 |
36,231,116 | nasal microbiom interact host childhood asthma childhood asthma major chronic non communic diseas infant children often trigger respiratori tract infect nasal caviti reservoir broad varieti commens microb potenti pathogen associ respiratori ill includ asthma healthi nasal microenviron protect effect respiratori tract infect first microbi colonis nasal region initi immedi birth subsequ colonis nasal microbiota infanc play import role rapid establish immun homeostasi develop matur immun system dysbiosi microbiota resid mucos surfac nasopharynx gut trigger immun modul sever infect exacerb event nasal microbiom dysbiosi relat onset symptomat infect dynam interact viral infect nasal microbiota earli life affect later develop respiratori infect review summaris exist find relat nasal microbiota colonis dynam variat host microbiom interact childhood health respiratori ill particular examin asthma also discuss current understand bias produc environment factor technic concern import standardis research method microbiom modif prevent treatment childhood asthma review lay groundwork pay attent essenti less emphas topic improv understand overal composit dynam chang influenc nasal microbiom associ childhood asthma | D001249;D064307;D012141 | T001;T047;T032;T028 |
36,231,115 | novel homozyg founder variant rtnip two consanguin saudi famili genet architectur mitochondri diseas continu expand current exceed diseas caus gene bi allel variant rtnip also known optic atrophi opa lead earli onset recess optic neuropathi atrophi encephalopathi afflict patient gene known encod mitochondri ubiquinol oxidoreductas interact reticulon thought mitochondri antioxid nadph oxidoreductas describ two unrel consanguin famili northern region saudi arabia harbor missens variant rtnip nm cg lt pvalph gene clinic affect individu present intellectu disabl encephalopathi ataxia optic atrophi seizur base whole exom sequenc confirmatori sanger sequenc variant fulli segreg phenotyp famili absent among larg ethnic match control well numer hous exom predict pathogen differ silico classifi structur model immunoblot analys strong indic variant pathogen sinc famili belong one tribal inhabit saudi arabia postul variant like founder provid estim age variant present data confirm diseas causal founder variant | D001927;D009896 | T047 |
36,231,114 | tfeb beyond role autophagi lysosom regul transcript factor eb tfeb consid master transcript regul autophagi lysosom biogenesi regul target gene express bind clear motif tfeb dysregul link develop numer patholog condit howev sever line evid show tfeb might point converg divers signal pathway might therefor modul import biolog process cellular senesc dna repair er stress carbohydr lipid metabol wnt signal relat process regul tfeb occur predomin post translat level includ phosphoryl acetyl sumoyl parsyl glycosyl noteworthi tfeb activ context depend therefor regul subject coordin mechan respond nutrient fluctuat also stress cell program ensur proper cell homeostasi organism health review provid updat insight novel post translat modif regul tfeb activ give overview tfeb beyond wide known role autophagi lysosom pathway thus open possibl consid tfeb potenti therapeut target | D001343;D008247 | T043;T026 |
36,231,113 | immunomodulatori effect bone homeostasi regul osteoblast differenti hadmsc via pd pd l axi human mesenchym stem cell hmscs promis candid stem cell therapi known secret program death pd ligand pd l regul cell mediat immunosuppress given limit current stem cell therapi approach improv immunomodulatori capac stem cell differenti efficaci need studi propos novel strategi overcom challeng remain hmsc mediat bone regener found pd high express osteoblast pd pd l axi mediat decreas proinflammatori cytokin express differenti osteoblast cocultur human adipos deriv mesenchym stem cell hadmsc moreov decreas attenu pd pd l pathway inhibit osteogen properti includ osteogen gene express calcium deposit increas osteoblast cocultur hadmsc compar monocultur osteoblast treat pd l exosom hadmsc also exhibit enhanc osteogen properti includ calcium deposit osteogen gene express cocultur system mimic physiolog condit bone matrix pd pd l axi mediat increas express osteogen gene therebi enhanc osteogen properti calcium deposit osteoblast maintain result provid therapeut potenti novel role pd pd l axi bone matrix modul bone properti immunosuppress potenti aid prevent bone diseas via maintain bone homeostasi | D059630;D061026 | T025;T192;T116;T129 |
36,231,112 | structur heterogen gabaerg tripartit synaps concept tripartit synaps describ close interact pre postsynapt element surround astrocyt process glutamaterg synaps establish presenc astrocyt process structur arrang vari consider within brain region synaps neuron contrast less known organ astrocyt process gabaerg synaps although bi direct signal known exist synaps therefor establish super resolut expans microscopi gabaerg synaps nearbi astrocyt process stratum radiatum mous hippocamp ca region visual presynapt vesicular gaba transport postsynapt cluster protein gephyrin document subsynapt heterogen gabaerg synapt contact compar volum distribut astrocyt process near gabaerg synaps individu synaps glutamaterg synaps made two novel observ first astrocyt process abund gabaerg synaps larg postsynapt gephyrin cluster second astrocyt process less abund vicin gabaerg synaps compar glutamaterg suggest latter may select approach astrocyt gaba transport distribut also specul specif arrang enabl effici uptak gaba presynapt termin | D011963;D005680 | T121;T123;T116;T192 |
36,231,111 | railmap type interferon induct subcellular network plan virus chang track innat immun respons constitut cell first line defens virus culmin express type interferon ifn ifn stimul gene induc antivir state infect neighbor cell effici signal transduct key factor strong control type ifn express depend compartment differ step signal cascad dynam event involv compart organell compartment innat immun player reli associ membran organell also includ format supramolecular organ center smoc effector concentr liquid liquid phase separ success replic virus need evad innat defens evolv multitud strategi impair type ifn induct one disrupt spatial immun signal dynam review focus role compartment ensur adequ innat immun respons viral pathogen draw attent crucial transloc event occur downstream pattern recognit lead express type ifn furthermor intend highlight concis exampl viral countermeasur interf spatial organ allevi innat immun respons | D007370;D014780 | T121;T005;T116;T129 |
36,231,110 | novel insight role kissgpr system energi metabol major metabol organ kissgpr system multifunct genet system essenti role regul energi balanc metabol homeostasi mammalian hypothalamus two major popul neuron rostral periventricular region third ventricl rpv arcuat nucleus arc produc kisspeptin kiss arc neuron input kisspeptin glutam feed associ neuron regul energi intak expenditur balanc kisspeptin peripher circul involv lipid accumul adipos tissu hepat pancreat circuit kisspeptin signal affect insulin secret suggest critic role kissgpr system regul glucos lipid metabol addit review also predict role kissgpr system skelet muscl associ exercis perform recent studi focus link kisspeptin signal energi homeostasi investig potenti function warrant therefor review summar role kissgpr system major metabol organ relat energi metabol homeostasi aim endow reader critic updat view kissgpr system energi metabol | D004734;D059648 | T116;T123;T040;T039 |
36,231,109 | next generat immuno oncolog strategi unleash nk cell activ recent year immunotherapi becom power therapeut option multipl malign uniqu capac natur killer nk cell attack cancer cell without antigen specif make optim immunotherapeut tool target tumor sever approach current pursu maxim anti tumor properti nk cell clinic includ develop nk cell expans protocol adopt transfer establish favor microenviron nk cell activ redirect nk cell activ tumor cell blockag inhibitori mechan constrain nk cell function summar recent strategi nk cell base immunotherapi discuss requir optim approach enhanc clinic outcom nk cell base immunotherapi target tumor | D007167;D009369 | T191;T061 |
36,231,108 | global transcript epigenet reconfigur chemic reprogram human retin pigment epitheli cell photoreceptor like cell retin degen diseas frequent caus loss retin neural cell photoreceptor cell replac regard one promis therapi multipl type stem somat cell test photoreceptor convers howev current induct effici still low molecular mechan under reprogram remain clarifi work combin treatment small molecul direct reprogram human fetal retin pigment epitheli rpe cell chemic induc photoreceptor like cell cipc vitro bulk singl cell rna sequenc well methyl sequenc perform understand transcript epigenet chang cipc convers multi omic analysi show direct reprogram process part resembl event earli retina develop also found effici cipc convers rpe much better human dermal fibroblast hdf small molecul effect induc rpe cell cipc via suppress epitheli mesenchym transit emt among signal pathway involv cipc convers glutam receptor activ promin summari rpe cell effici reprogram photoreceptor like cell defin pharmacolog modul provid use cell sourc photoreceptor generat cell replac therapi retin degen diseas | D012162;D055213 | T023;T046 |
36,231,107 | chromatin liquid liquid phase separ llps regul ionic condit fiber length dynam regul physic state chromatin cell nucleus crucial maintain cellular homeostasi chromatin exist solid liquid like form depend surround ion bind protein post translat modif mani factor sever recent studi suggest chromatin undergo liquid liquid phase separ llps vitro also vivo yet controversi conclus natur chromatin llps also observ vitro studi inconsist partial due deviat vitro buffer condit induc condensationaggreg chromatin well differ chromatin nucleosom array construct use studi work present detail character effect k mg nucleosom fiber length physic state properti reconstitut nucleosom array llps general observ shorter nucleosom array reconstitut repeat widom dna bp nucleosom repeat length physiolog ion concentr contrast gel solid like condens detect consider longer lambda dna kbp nucleosom array condit addit demonstr presenc reduc bsa acet buffer essenti chromatin llps process overal studi provid comprehens understand sever factor regard chromatin physic state shed light mechan biolog relev chromatin phase separ vivo | D002843;D009707 | T123;T116 |
36,231,106 | bta mir target rhob gene dairi cow attenu lps induc inflammatori respons mammari epitheli cell bovin mammari epitheli cell bmec part first line defens pathogen recent studi bta mir report activ congenit innat immun inflammatori damag pathogenesi mastiti dairi cow purpos studi identifi regulatori mechan bta mir downstream target gene inflammatori bmec doubl luciferas report gene assay demonstr ras homolog famili member b rhob target gene bta mir elucid role bta mir congenit immun respons bta mir mimic mimicinhibitor transfect bmec stimul lipopolysaccharid lps activ toll like receptor nuclear factor b tlrnf b signal pathway real time quantit pcr qpcr western blot use detect express relat gene protein enzym link immunosorb assay elisa use detect secret inflammatori factor result show bta mir express inflamm bmec reduc secret inflammatori factor target rhob deactiv nf b gene activ silenc rhob inhibit lps induc inflammatori respons bmec overal bta mir attenu lps induc inflammatori respons act negat feedback regul via target rhob provid novel avenu mastiti treatment | D008413;D035683 | T047;T123;T114 |
36,231,105 | axon guidanc molecul pain chronic pain debilit condit influenc social econom psycholog aspect patient live henc need better treatment draw extens interest research communiti development molecul wnt ephrin semaphorin acknowledg central player proper growth biolog system receptor ligand express wide varieti neuron glial cell implic pain develop mainten resolut therebi surpris impair pathway affect activ function entir cell evid indic aberr activ pathway nervous system rodent model chronic pain condit wnt ephrin semaphorin signal particip enhanc neuron excit peripher sensit synapt plastic product releas inflammatori cytokin review summar current knowledg three main development pathway mechan link pathogenesi progress pain consid impact neuron glial cell experiment anim model elucid downstream pathway may provid new mechan involv wnt ephrin semaphorin pathway pain chronic | D059350;D039961 | T047;T184;T123;T116 |
36,231,104 | willinfrmd mediat mitochondri dysfunct relev neuron toxic willin frmd report potenti alzheim diseas ad risk gene seri genom wide associ neuroimag studi howev mechan under potenti role ad pathogenesi remain unknown demonstr direct effect willinfrmd express posit mitochondri oxid stress novel potenti mechan under role willinfrmd ad pathogenesi specif use mous hippocamp ht cell primari mous neuron show induc downregul willinfrmd protein express furthermor demonstr willinfrmd knockdown lead mitochondri dysfunct fragment well upregul erk signal report key earli featur ad pathogenesi import increas willinfrmd express abl rescu induc abnorm mitochondri morpholog function energet thus enhanc willinfrmd express hold potenti therapeut strategi protect induc mitochondri neuron dysfunct | D016229;D055106 | T063;T116 |
36,231,103 | hierarch cluster trajectori analys reveal viremia independ b cell perturb hiv infect time aid hiv infect approxim twice long compar hiv infect despit reduc viremia hiv infect individu display sign chronic immun activ hiv infect individu b cell hyperactiv driven continu antigen exposur howev contribut viremia b cell perturb hiv infect individu remain larg unexplor use polychromat flow cytometri consensus hierarch cluster pseudotim trajectori infer character b cell hiv hiv infect hiv seroneg individu observ increas frequenc cluster contain hyperactiv bet high cd high cd int prolifer bet cd high cd cd memori b cell virem hiv p lt p lt respect virem hiv p lt p respect treatment nave avirem hiv p p respect infect individu compar seroneg individu contrast expans observ success treat hiv infect individu final pseudotim trajectori infer show bet express hyperactiv prolifer memori b cell popul locat termin end two trajectori hiv hiv infect treatment nave avirem hiv infect individu success art treat hiv infect individu show b cell perturb data suggest avirem hiv infect individu would also benefit antiretrovir treatment | D015658;D006679;D015497 | T047;T005;T034 |
36,231,102 | alg promot periton metastasi ovarian cancer increas interact mannosyl upar adam periton metastasi main caus poor prognos high mortal ovarian cancer patient abnorm protein glycosyl modif associ cancer malign elev mannosyltransferas alg catalyz mannosyl glycoprotein found malign tumor howev patholog signific alg regulatori mechan ovarian cancer metastasi unclear result show level alg mannosyl higher human ovarian cancer tissu compar normal ovarian tissu measur lectin chip western blot lectin blot analys well ovarian tissu microarray analysi alg also correl poor prognosi ovarian cancer patient accord surviv analysi downregul alg decreas prolifer stem periton metastasi ovarian cancer cell increas urokinas plasminogen activ receptor upar mannosyl catalyz alg enhanc urokinas plasminogen activ upa upar activ interact upar disintegrin metalloproteinas adam promot ovarian cancer periton metastasi via adamraserk pathway furthermor decreas alg suppress ascit format periton metastasi ovarian cancer cell mice studi highlight alg potenti diagnost biomark prospect therapeut target ovarian cancer | D010051;D010534 | T191 |
36,231,101 | necrostatin allevi lung ischemia reperfus injuri via inhibit necroptosi apoptosi lung epitheli cell lung ischemia reperfus injuri liri associ mani diseas includ primari graft dysfunct lung transplant specif effect therapi necroptosi contribut pathogenesi ischemia reperfus injuri necrostatin nec necroptosi inhibitor target ripk report allevi ischemia reperfus injuri various organ howev under mechan nec liri remain unclear paper vivo liri model built left lung hilar clamp mice vitro cold ischemia reperfus cir model use bea b cell appli mimic lung transplant set found nec signific allevi ischemia reperfus induc lung injuri cytokin releas necroptosi epitheli cell mous lung vitro nec also mitig cir induc cell death inflammatori respons bea b cell protect effect achiev simultan inhibit format necrosom ripk depend apoptosi howev nec decreas necrosom number increas apoptosi level lung tissu ischemia reperfus clarifi nec could also attenu lung injuri promot neutrophil apoptosi flow cytometri conclus nec allevi lung ischemia reperfus injuri inhibit necroptosi apoptosi epitheli cell promot apoptosi neutrophil thus nec could promis medic primari graft dysfunct lung transplant | D055370;D055031;D015427 | T047;T046;T037 |
36,231,100 | genet associ farrow rate swine leukocyt antigen allel haplotyp microminipig previous report specif swine leukocyt antigen sla haplotyp associ signific effect sever reproduct perform trait high inbr miniatur pig popul microminipig mmps studi clarifi effect farrow rate sla similar mate partner mmp popul compar farrow rate measur reproduct success cumul mate among follow three group mate partner complet share sla class class ii haplotyp allel partner cs one share haplotyp allel os non share haplotyp allel ns averag farrow rate cs group consist complet share sla class ii haplotyp drbi dqb allel lowest three group moreov lower farrow rate indic mate pair smaller amino acid pairwis genet distanc sla sla drb dqb allel pair result suggest dissimilar sla class class ii allel mate partner mark improv reproduct perform therefor sla allel haplotyp potenti use genet marker select mate pair breed program epistat studi reproduct trait mmps | D000596;D000949 | T121;T123;T116;T129 |
36,231,099 | toll like receptor polymorph aspg associ increas risk ovarian cancer ovarian cancer oc one common cancer threaten women live around world epitheli ovarian tumor repres common ovarian neoplasm oc patient diagnos advanc stage urgent need identifi novel biomark diseas singl nucleotid polymorph snps tlr gene may serv crucial marker cancer suscept investig frequenc tlr polymorph group women includ oc four snps two tlr rs rs tlr rs rs analyz use polymeras chain reaction restrict fragment length polymorph pcr rflp digest fragment separ identifi multicapillari electrophoresi load quantif human papillomavirus hpv type determin use digit droplet pcr method found increas frequenc heterozyg genotyp minor allel tlr rs snp women oc compar healthi control result remain high signific bonferroni correct multipl test p lt evid linkag disequilibrium found examin tlr snps find suggest tlr aspg polymorph could genet risk factor develop oc | D010051;D051197 | T191;T116;T192 |
36,231,098 | systemat interrog temperatur perturb insulin signal pathway optogenet stimul applic nir optogenet system great demand due superior properti enabl vivo deep tissu penetr irradi nir tissu sampl cell rapid generat heat local result elev temperatur affect cell molecular level activ heat shock pathway ros generat nevertheless report present detail comparison effect temperatur chang rate signal pathway biomolecul especi rapid heat chang aim broaden understand temperatur sensit investig seven insulin signal pathway biomolecul insr ir akt gsk psk foxo erk three cell line cc hepg fao temperatur c result show except insr pakt foxo biomolecul sensit rapid temperatur chang temperatur higher c signific phosphoryl c around reduct phosphoryl occur moreov psk sensit time dephosphoryl quick min phosphoryl time find extend temperatur rang c provid addit time cours inform signal pathway biomolecul respons necessari advanc nir optogenet research | D007328;D038762 | T121;T126;T116;T125 |
36,231,097 | astrocyt heterogen regul synapt activ awar number synaps regulatori function perform astroglia rapid expand rais interest question regard astrocyt heterogen special across brain region whether astrocyt pois signal multitud way instead tune surround synaps astrogli signal alter psychiatr cognit disord fundament question field recent year molecular morpholog character astrogli type broaden abil design studi better analyz manipul specif function astroglia recent data emerg studi discuss depth review also highlight remain question emerg new techniqu recent appli toward understand role astrocyt synaps regul adult brain | D001253;D013569 | T025;T030 |
36,231,096 | understand cell model characterist rna express profil primari immort human mesotheli cell human vein microvascular endotheli cell vitro studi essenti pre clinic research choic cell line often driven handl cost effect depth knowledg specif characterist scant mesotheli cell interact endotheli cell wide use research includ cancer drug develop comprehens profil therefor perform rna sequenc polar primari periton hpmc immort pleural mesotheli cell met compar endotheli cell umbil vein huvec cardiac capillari hcmec seventi seven per cent gene share cell line mesotheli endotheli cell specif transcript reflect major differ hpmc met dna relat process extracellular matrix migrat prolifer adhes transport growth factor immun respons huvec hcmec dna replic extracellular matrix adhes organ high variabl share gene relat six cluster cell tissu origin immort also cell migrat capac cell adhes regul angiogenesi respons hypoxia distinct cell type specif biolog process describ cellular compon molecular function reactom pathway analys provid crucial inform specif featur frequent use mesotheli endotheli cell line essenti appropri use | D042783;D012313 | T025;T114 |
36,231,095 | sleep alter mous model spinocerebellar ataxia type spinocerebellar ataxia type sca neurodegen disord show progress neuron loss sever brain area broad spectrum motor non motor symptom includ ataxia alter sleep sleep disturb known play pathophysiolog role neurodegen disord impact sca unknown use spectrograph measur sought quantit character sleep electroencephalographi eeg sca transgen mice confirm diseas phenotyp first measur motor phenotyp week old homozyg sca yacmjd mice non transgen wild type litterm mice light light period next implant electrod obtain h zeitgeb time eeg record three consecut day mice week old eeg base spectroscopi show compar wild type litterm sca homozyg mice display increas durat rapid eye movement sleep rem fragment sleep wake state ii higher beta power oscil rem non rem nrem iii addit spectral power band alter rem wake data show sleep architectur eeg spectral power dysregul homozyg sca mice indic common sleep relat etiolog factor may underli mous human sca phenotyp | D017827 | T047 |
36,231,094 | direct differenti human embryon stem cell function hepatocyt like cell algin microencapsul sphere lack stabl sourc hepatocyt one major limit hepatocyt transplant clinic applic bioartifici liver human embryon stem cell hesc high degre self renew totipot potenti limitless sourc varieti cell lineag includ hepatocyt mani techniqu develop effect differenti hesc function hepatocyt like cell howev applic hesc deriv hepatocyt like cell hesc hep clinic constrain low yield fulli differenti cell small scale cultur difficulti harvest immunolog graft reject resolv shortcom develop novel differenti system involv algin microencapsul sphere improv current hepat differenti provid readi use hesc hep | D000066449 | T025 |
36,231,093 | stat target inhibitor oral squamous cell carcinoma oral squamous cell carcinoma oscc usual origin precancer lesion oral mucosa account approxim oral cancer current therapeut approach yet meet need patient year surviv rate patient oscc recent studi reveal signal transduc activ transcript stat play key role develop progress oscc stat overexpress constitut activ oscc cell promot cancer cell prolifer anti apoptosi migrat invas angiogenesi radiotherapi resist immun escap well stem cell self renew differenti regul transcript downstream target gene inhibitor stat signal pathway shown promis anticanc effect vitro vivo stat expect molecular target treatment oscc review highlight oncogen signific stat oscc emphasi therapeut approach effect small molecul inhibitor target stat final also propos potenti research direct expect develop specif stat inhibitor oscc treatment | D002294;D006258;D009062 | T191 |
36,231,092 | intrachromosom loop histon k methyl coordin regul lncrna h fetal mitogen igf imprint cluster decidu microenviron earli pregnanc recurr spontan abort rsa high heterogen complic pregnanc under mechan remain uncharacter dysregul decidu critic contributor phenotyp alter relat pregnanc complic understand molecular factor under rsa explor role longnoncod rnas lncrnas decidu microenviron crosstalk fetal matern interfac occur explor rna seq data rsa patient identifi h noncod rna exhibit matern monoallel express one upregul lncrnas associ rsa patern express fetal mitogen igf reciproc coregul h within imprint cluster also upregul notabl gene underw loss imprint h igf activ transcrib parent allel decidu tissu loss imprint decidu tissu associ loss hkm repress histon marker igf promot cpg hypomethyl central ctcf bind site imprint control center icr loss ctcf mediat intrachromosom loop data suggest dysregul higf imprint pathway may import epigenet factor decidu microenviron relat poor decidu | D006657;D062085 | T123;T116;T114 |
36,231,091 | fgfr mutat pcysarg enhanc mitochondri metabol mediat osteogenesi via fgffgfr ampk erk axi crouzon syndrom crouzon syndrom omim caus fgfr mutat autosom domin syndrom craniosynostosi under mechan remain obscur | D003394;D003398 | T047;T019 |
36,231,090 | c al associ prolin arginin dipeptid repeat protein induc activ nlrp inflammasom hmc microglia cell bind complement compon q subcompon bind protein cqbp syringin prevent effect amyotroph later sclerosi al fatal diseas motor neuron gradual degener mutat corf gene main genet caus al c al one specif patholog featur product prolin arginin pr dipeptid repeat protein dpr studi develop pr dpr pr express human hmc microgli cell model found pr main aggreg spot nucleus induc signific nlrp inflammasom activ moreov mous nsc motor neuron cell treat condit medium pr express hmc cell pr cm caus cell damag apoptosi activ howev r express hmc cell treat mcc nlrp inhibitor revers result furthermor identifi complement compon q subcompon bind protein cqbp one interact partner pr downregul cqbp hmc cell induc nlrp inflammasom activ similar pr express final found syringin block interact pr cqbp effect reduc pr induc nlrp inflammasom activ hmc cell improv apoptosi nsc cell caus pr cm studi first link pr cqbp nlrp inflammasom activ microglia develop potenti therapeut strategi syringin intervent c al | D000690 | T047 |
36,231,089 | fli men discoveri tlrs nobel prize physiolog medicin award three immunologist bruce beutler jule hoffmann ralph steinman steinman honor work dendrit cell adapt immun beutler hoffman receiv prize contribut discoveri innat immun hoffmann found toll gene crucial mount antimicrobi respons fruit fli first implic development gene immun signal two year later beutler built observ describ toll like gene tlr receptor bacteri product lps repres crucial step innat immun activ protect bacteri infect mammal public spearhead research innat immun sens spark huge interest regard innat defens mechan follow year decad today beutler hoffmann research result discoveri role multipl tlrs innat immun also much broader understand molecular compon innat immun system review aim collect discoveri lead public beutler hoffmann take close look earli advanc development biolog immunolog converg research award nobel prize also discuss discoveri influenc futur research highlight import hold today | D008070;D051197 | T109;T116;T192 |
36,231,088 | hoci probe cpp induc differenti human dermal fibroblast vascular endotheli cell phdhif hey signal pathway human dermal fibroblast hdfs potenti differenti endotheli cell vec previous research report hypochlor acid hocl probe cpp effici induc differenti hdfs vec howev mechan differenti clear hoci probe cpp bind hoci modul effect studi western blot qpcr phd enzym activ assay found cpp inhibit enzym activ prolyl hydroxylas phd therebi stabil hif clarifi mechan cpp inhibit phd enzym activ construct plasmid found cpp inhibit phd activ increas hif level modul phd cys hocl hdfs furthermor rna seq experi show cpp could induc express hey target gene regul hif also key transcript factor vec use sirna transfect vivo experi confirm cpp could induc hdfs differenti vec hey summari identifi new inhibitor phd demonstr new role hocl cell differenti elucid mechan hocl probe cpp induc differenti hdfs vec | D042783;D064799 | T025;T126;T116 |
36,231,087 | covid patholog lung kidney heart brain differ role cell macrophag microthrombosi aim describ covid patholog across differ tissu clarifi diseas pathophysiolog lung kidney heart brain nine covid autopsi compar use antibodi sar cov macrophag microglia lymphocyt b lymphocyt activ platelet alzheim diseas patholog also assess pcr techniqu use verifi presenc viral rna covid case short clinic cours day mean age yo hypox chang inflammatori infiltr present across tissu lymphocyt compon lung kidney predomin tissu p lt signific greater presenc lymphocyt lung p show greatest presenc viral antigen heart show scant sar cov trace endothelium endocardium foci activ macrophag rare lymphocyt brain show scarc sar cov trace promin microgli activ rare lymphocyt pon exhibit highest microgli activ p microthrombosi signific higher covid lung p compar control characterist patholog featur covid abund lymphocyt microthrombosi lung relev microgli hyperactiv brainstem studi suggest long term sequela covid deriv persist inflamm rather persist viral replic | D000086382;D013927 | T047;T046;T067 |
36,231,086 | singl cell transcriptom understand hsc heterogen evolut upon age singl cell transcriptom technolog enabl uncov character cellular heterogen pave way studi aim understand origin consequ hematopoiet system essenc well adapt model system benefit technolog advanc character differ cellular state cellular state interconnect may defin specif locat global transcript landscap sustain complex regulatori network transcriptom signatur fix evolv time give rise less effici hematopoiet stem cell hsc lead well document hematopoiet age review advanc singl cell transcriptom approach understand hsc heterogen grasp hsc deregul upon age also discuss new bioinformat tool develop analysi result larg complex dataset final sinc hematopoiesi driven fine tune complex network must interconnect highlight mathemat model benefici interconnect multilay inform predict hsc behav age | D006412;D059467 | T025;T081;T086 |
36,231,085 | supraphysiolog oxygen level mammalian cell cultur current state futur perspect convent incub use cell cultur regul level make headspac concentr contrast human tissu expos physioxia vivo accumul evid shown hyperox condit standard cell cultur practic affect varieti biolog process review discuss supraphysiolog level affect reactiv oxygen speci ros metabol redox homeostasi gene express replic lifespan cellular respir mitochondri dynam furthermor present evid demonstr hyperox cell cultur condit fail recapitul physiolog patholog behavior tissu vivo includ case alter cellular respons drug hormon toxic conclud maintain physioxia cell cultur imper order better replic vivo like tissu physiolog patholog avoid artifact research involv cell cultur | D018496;D010100 | T121;T184;T123;T196 |
36,231,084 | network base analysi identifi hub gene involv spatial root respons mechan constrain previous studi report asymmetr respons observ along main poplar woodi bent root axi strong relat type mechan forc compress tension intens forc displac despit larg number target propos trigger asymmetri understand comprehens synergist effect antistress spatial relat pathway still lack recent progress bioinformat area potenti fill gap use silico studi abl investig biolog function pathway overlap identifi promis target plant respons present first time comprehens network base analysi proteom signatur use identifi function pivot gene involv coordin signal pathway molecular activ asymmetr modul respons differ bent poplar root sector side accomplish aim candid protein differenti repres across poplar bent root side sector group accord abund profil pattern map togeth first neighbour high confid set interact string compos specif cluster relat subnetwork vi success subnetwork explor function gene set enrich analysi identifi enrich gene ontolog term subnetwork analys identifi gene strong interconnect gene hub gene thus pivot role bent root asymmetr respons analysi reveal novel inform regard respons coordin communic potenti signal pathway asymmetr activ along main root axi deleg main ca new later root format ros gravitrop respons lignin accumul signatur furthermor data indic concav side bent sector mechan forc intens communic neighbour distant sector induc spatial relat strategi ensur water uptak accompani cell modif inform could critic understand plant maintain improv structur integr whenev wherev necessari natur mechan stress condit | D018506;D032107 | T045;T002 |
36,231,083 | blood endotheli cell extracellular vesicl potenti biomark select plasma covid convalesc plasma therapi despit advanc vaccin therapi current avail death due coronavirus diseas covid still heavili document sever infect individu experi general inflammatori storm caus massiv secret pro inflammatori cytokin lead endotheli dysfunct cardiovascular diseas multi organ failur even death covid convalesc plasma ccp therapi select primarili base anti sar cov antibodi level convinc expect fight covid given consequ dysfunct endothelium progress diseas propos select plasma ccp therapi base specif paramet take consider effect vascular inflamm thus present studi character subset ccp use ccp therapi measur anti pro inflammatori effect human coronari arteri endotheli cell hcaec data reveal longer time laps onset symptom plasma donat mitochondri dysfunct evidenc concentr blood endotheli cell extracellular vesicl bec ev increas plasma young individu mild symptom type select convalesc plasma promot activ blood vascular endothelium reflect overexpress icam nfb downregul cadherin propos mechan warn signal sent injur endothelium trigger self defens peripher blood vessel excess inflamm therefor result line previous data suggest specif select covid convalesc plasma base time donat follow onset clinic symptom donor sever symptom age donor characterist relat easi identifi hospit would reflect concentr plasma bec ev optim ccp therapi | D000086382;D018352;D000067128;D011024 | T047;T026;T067 |
36,231,082 | platelet deriv extracellular vesicl stimul migrat partial remodel ca handl machineri mda mb breast cancer cell platelet support cancer progress via releas microparticl microvesicl enhanc migratori behaviour recipi cancer cell recent show platelet deriv extracellular vesicl pev stimul migrat invas high metastat mda mb cell stimul phosphoryl p mapk myosin light chain mlc herein assess whether pro migratori effect pev involv remodel ca handl machineri drive mda mb cell motil | D001943;D000067128 | T191;T026 |
36,231,081 | concis review stem cell model scna relat encephalopathi current perspect futur therapi mutat scna gene caus varieti phenotyp rang mild form febril seizur general epilepsi febril seizur plus sever dravet non dravet development epilept encephalopathi two thousand pathogen variant scna gene identifi differ pathogen mechan loss vs gain function describ precis molecular mechan respons deficit exhibit patient fulli elucid addit phenotyp variabl prove involv genet factor final express reason anim model cell line model use explor molecular patholog scna relat disord limit use result studi base model direct translat affect individu address patient uniqu genet background generat function neuron glia patient deriv ipsc togeth generat isogen control use crisprca technolog final brain organoid model seem good way solv problem review scna relat encephalopathi well stem cell model use explor molecular basi | D001927;D004831;D057026;D003294 | T047;T025 |
36,231,080 | character aquaporin inhibitor rg vitro dbdb mice aquaporin aqp facilit glycerol small neutral solut transmembran diffus identif specif inhibitor aquaporin famili protein difficult due high sequenc similar human isoform due limit channel surfac area permit inhibitor bind aqp inhibitor molecul describ date suitabl vivo experi describ character new small molecul aqp inhibitor rg cell base calcein quench assay stop flow light scatter record aqp permeabl proteoliposom moreov investig effect rg glycerol metabol mice cell base assay rg block aqp water permeabl glycerol permeabl similar high potenc aqp channel block rg confirm proteoliposom oral gavag dbdb mice rg dose depend elev plasma glycerol observ blood glucos lower effect statist signific experi establish rg direct blocker aqp channel suggest use experiment tool vivo experi aqp function | D020346;D005990 | T121;T109;T123;T116 |
36,231,079 | vivo inhibit mir modest limit cardiac enlarg fibrosi mous model establish type diabet induc cardiomyopathi improv diastol function microrna mir elev heart set cardiac stress patholog previous report inhibit mir vivo provid protect set pressur overload induc patholog cardiac hypertrophi dilat cardiomyopathi prior work also shown circul cardiac mir elev set diabet howev therapeut potenti inhibit mir vivo diabet heart assess current studi type diabet induc adult male mice daili inject streptozotocin stz week post stz mice establish type diabet diastol dysfunct mice administ lock nucleic acid lna antimir salin control eight week follow cardiac function cardiac morpholog cardiac fibrosi capillari densiti gene express assess diabet mice present high blood glucos elev liver kidney weight diastol dysfunct mild cardiac enlarg cardiac fibrosi reduc myocardi capillari densiti mir elev heart diabet mice comparison non diabet mice inhibit mir signific effect diastol function atrial enlarg mild effect prevent elev cardiac enlarg fibrosi ventricular gene express b type natriuret peptid bnp anti angiogen mirna mir mir target vinculin invers correl mir express mir target unchang summari inhibit mir provid limit protect mous model establish type diabet induc cardiomyopathi fail improv diastol function given diabet repres system disord numer mirna dysregul diabet heart well organ strategi target multipl mirna andor earlier intervent like requir | D002311;D003922;D035683 | T047;T123;T114 |
36,231,078 | role runx protein lymphocyt function anti tumor immun runt relat transcript factor runx famili protein crucial mani development immuno physiolog process import cellular tissu develop repeat demonstr often found mutat implic tumorigenesi import runx emerg critic regul lymphocyt function pathogen infect tumorigen cell latter revolution current understand runx protein contribut control tumor pathogen multifunct role runx mammalian immun respons tissu homeostasi led us appreci valu control anti tumor immun respons summar discuss role runx regul develop function lymphocyt respond foreign tumorigen threat highlight key role anti tumor immun | D050657;D009369 | T191;T123;T116 |
36,231,077 | k ubiquitin p facilit pellino context chronic obstruct pulmonari diseas lung cellular senesc chronic obstruct pulmonari diseas copd kind age relat airflow obstruct diseas most caus cigarett smoke howev relationship copd lung cellular senesc still fulli understood found silenc pellino could inhibit protein level p construct cell line express ubiquitin ha found e ubiquitin ligas pellino could bind senesc marker p modifi p k site ubiquitin co ip assay furthermor found p mediat lung cellular senesc could inhibit silenc pellino galactos senesc mice model moreov construct copd mous model shpellino adenovirus found silenc pellino could inhibit copd inflamm via reduct sasp regul p taken togeth studi find elucid silenc e ligas pellino exhibit therapeut potenti treatment attenu progress lung cellular senesc copd | D005690;D029424 | T047;T109;T123 |
36,231,076 | liquid biopsi translat bridg time clinic research advanc understand tumor immun microenviron time vital optim direct effect cancer immun therapi pre clinic bench research vital better understand genom interplay time immun therapi respons howev vital key effect translat cancer research bridg translat bring understand bench bedsid without bridg research time lack effici effect translat clinic cancer treatment decis make clinic oncologist purpos commentari emphas import research improv clinic util bridg well time research | D009369;D059016 | T191;T070 |
36,231,075 | tryptophan catabolit kynurenin pathway major depress episod melancholia psychot featur suicid behavior systemat review meta analysi major depress disord mdd bipolar disord bd melancholia psychot featur suicid behavior accompani activ immun inflammatori oxid pathway may stimul indoleamin dioxygenas ido first rate limit enzym tryptophan catabolit trycat pathway result increas tryptophan degrad elev tryptophan catabolit trycta purpos current studi systemat review meta analyz level trp compet amino acid caa trycat patient sever affect disord method pubm googl scholar scifind search present studi recruit studi examin particip includ unipolar mdd bipolar bd depress patient healthi control sever patient show signific lower p lt trp standard mean differ smd confid interv ci trpcaa smd ci level moder effect size signific differ caa found kynurenin kyn level unalt sever mddbd phenotyp kyntrp ratio show signific increas patient psychot featur smd ci quinolin acid qa signific increas smd ci kynuren acid ka signific decreas smd ci sever mddbd patient affect disord melanchol psychot featur suicid behavior show normal ido enzym activ lower avail plasmaserum trp brain probabl due process low albumin level | D003865;D007737 | T123;T116;T048 |
36,231,074 | withaferin attenu retin ischemia reperfus injuri via akt depend inhibit oxid stress background retin ischemia reperfus ir injuri often result intract visual impair surviv retin capillari endotheli cell crucial treatment retin ir injuri protect retin endothelia damag challeng work withaferin small molecul deriv plant antibacteri anti inflammatori effect use millennia tradit medicin present studi aim investig potenti protect effect withaferin retin ir injuri method drug like withaferin evalu swissadm web tool potenti protect effect withaferin ir induc injuri human retin microvascular endotheli cell hrmec investig use multipl approach rna sequenc perform associ mechanist signal pathway analyz base kyoto encyclopedia gene genom data analyt result rna sequenc data valid vitro vivo experi result withaferin reduc ir injuri induc apoptot death hrmec vitro good drug like properti rna sequenc experiment valid result indic withaferin increas product crucial antioxid molecul heme oxygenas ho peroxiredoxin prdx ir addit withaferin activ akt signal pathway increas express ho prdx therebi exert antioxid effect attenu retin ir injuri decreas apoptosi hrmec blockad akt complet abolish effect withaferin conclus studi identifi first time withaferin protect ir induc apoptosi human microvascular retin endotheli cell via increas product antioxid prdx ho result suggest withaferin promis drug candid treatment retin ir injuri | D051547;D015427 | T126;T116;T037 |
36,231,073 | diverg effect adolesc ethanol exposur tripartit synapt develop across prefront cortex subregion adolesc development period encompass limit puberti continu earli adulthood period matur refin observ across brain region prefront cortex pfc critic cognit function adolesc also time excess alcohol consumpt form bing drink peak increas risk long term cognit deficit risk develop alcohol use disord later life anim model reveal adolesc ethanol etoh exposur result protract disrupt neuron function perform pfc depend task requir higher order decis make howev role astrocyt etoh induc disrupt prefront cortex depend function yet elucid astrocyt complex morpholog extens network peripher astrocyt process pap ensheath pre postsynapt termin form tripartit synaps tripartit synaps astrocyt play sever critic role includ synapt mainten dendrit spine matur neurotransmitt clearanc proxim depend interact investig effect adolesc bing etoh exposur astrocyt morpholog pap synapt proxim synapt stabil protein dendrit spine morpholog subregion pfc import emerg higher cognit function found adolesc bing etoh exposur result subregion specif chang astrocyt morpholog astrocyt neuron interact correspond loss astrocyt synaps dendrit spine correspond region specif etoh depend shift dendrit spine phenotyp last found chang astrocyt neuron interact consequ chang express key synapt structur protein neurexin neuroligin neuroligin data demonstr adolesc etoh exposur result endur effect neuron glia interact persist adulthood subregion specif pfc manner suggest select vulner work necessari understand function behavior implic | D000431;D012741 | T121;T109;T040 |
36,231,072 | alter cord blood lipid concentr correl birth weight doppler velocimetri fetal vessel human fetal growth restrict pregnanc fetal growth restrict fgr associ short long term morbid often fetal compromis utero evidenc abnorm doppler velocimetri fetal vessel lipid vital growth develop metabol fgr pregnanc fetus grow full genet potenti poor understood hypothes triglycerid concentr increas placenta import complex lipid reduc cord plasma pregnanc produc smallest babi birth weight lt correl ultrasound doppler doppler umbil arteri ua middl cerebr arteri mca assess longitudin pregnanc diagnos estim fetal weight efw lt week gestat subset enrol women placenta cord blood collect deliveri fatti acid extract target lipid class analysi triglycerid tg phosphatidylcholin pc lysophosphatidylcholin lpc eicosanoid perform lcms sub analysi particip categor fgr fenton birth weight bw sga control fenton bw gt fgrs n deliv week earlier p smaller p higher ua pulsatil index pi p sgas n fgr plasma tg free arachidon acid aa sever eicosanoid increas p lt docosahexaeno acid dha lpc decreas p lt plasma tg correl invers bw p lt plasma eet non esterifi aa dha correl invers bw direct ua pi p lt placent dha pc aa pc correl direct mca pi p lt fetus initi refer inadequ fetal growth efw lt bw demonstr distinct differ cord plasma lipid profil bw gt correl doppler pis provid new insight fetal lipidom respons fgr utero environ impact chang specif process growth develop particular fetal brain elucid relationship doppler pi may provid addit context fgr surveil target approach nutrit manag infant | D005312;D005317 | T046;T031 |
36,231,071 | emerg role pericyt deriv extracellular vesicl vascular neurolog health pericyt pcs central compon neurovascular unit contribut regen potenti central nervous system cns peripher nervous system pns virtu role blood flow regul angiogenesi mainten bbb neurogenesi neuroprotect emerg evid indic pcs also role mediat cell cell communic secret extracellular vesicl ev extracellular vesicl cell deriv micro nano size vesicl transport cell constitu protein nucleic acid lipid parent origin cell recipi cell pc deriv ev pc ev play crucial homeostat role neurovascular diseas promot angiogenesi maintain integr blood tissu barrier provid neuroprotect cargo carri pc ev includ growth factor endotheli growth factor vegf connect tissu growth factor ctgfs fibroblast growth factor angiopoietin neurotroph growth factor brain deriv neurotroph growth factor bdnf neuron growth factor ngf glial deriv neurotroph factor gdnf well cytokin interleukin il il il mcp pc ev also carri mirna circular rna link neurovascular health progress sever vascular neuron diseas therapeut strategi employ pc ev potenti treatment vascular neurodegen diseas review discuss current research characterist featur ev secret pcs role neuron vascular health diseas | D000067128;D035683 | T026;T123;T114 |
36,231,070 | genotyp environ interact analysi metabolit pearl millet genotyp high concentr slowli digest resist starch grain genotyp environ interact gei play import role select suitabl germplasm breed programm assess gei effect pearl millet pennisetum glaucum l genotyp select possess high concentr slowli digest starch sds resist starch rs grain entri grown random complet block design three replic locat bawku ghana sador niger bamako mali konni nigeria gampella burkina faso across west africa harvest grain locat metabolom profil use flow inject ionize high resolut mass spectrometri fie hrms total mass featur mz negat ion mode posit ion mode detect mz link metabolit involv starch antioxid lipid biosynthesi vitamin metabol combin anova reveal gei signific evid health benefit metabolit mani associ sugar especi galactos metabol addit main effect multipl interact ammi analysi examin genotyp variat gei effect combin princip compon analysi pca found mz posit ionis propenyl heptano account gei variat along pc ammi base stabil paramet astab modifi ammi stabil valu masv modifi ammi stabil index masi appli identifi stabl high perform genotyp health benefit metabolit similar best linear unbias predict blup base stabil estim also perform use harmon mean genotyp valu hmgv relat perform genotyp valu rpgv harmon mean relat perform genotyp valu hmrpgv identifi genotyp rank across multipl environ multi trait stabil index mtsi calcul found genotyp g icmh g icmx stabl best mean perform across health benefit metabol trait find demonstr potenti g e assess deliveri health benefit metabolit rich grain futur varieti hybrid pearl millet | D031782 | T002 |
36,231,069 | anti inflammatori properti sglt inhibitor empagliflozin activ primari microglia sodium glucos cotransport sglt inhibitor includ empagliflozin routin use antidiabet drug recent studi indic besid benefici effect blood glucos level empagliflozin may also exert vascular anti inflammatori neuroprotect properti brain microglia crucial mediat inflamm neuroinflamm play key role neurodegen disord dampen microglia mediat inflamm may slow diseas progress context investig immunomodulatori effect empagliflozin activ primari microglia valid experiment model rat primari microgli cell activ pro inflammatori state stimul lps influenc empagliflozin express pro inflammatori mediat nos il tnf ilb anti inflammatori mediat il assess use quantit pcr elisa investig chang activ erk cascad western blot nfkb transloc immunostain observ empagliflozin reduc express pro anti inflammatori mediat lps activ primari microglia effect might mediat nhe rather sglt inhibit erk nfkb pathway result support putat anti inflammatori effect empagliflozin microglia suggest sglt inhibitor may exert benefici effect neurodegen disord | D000077203 | T121;T109 |
36,231,068 | transcriptom chang glioma cell cultiv condit neurospher format glioma common heterogen primari brain tumor develop new relev preclin model necessari research move cultur adher glioma relev model neurospher necessari understand chang cell undergo transcriptom level present work use three patient deriv glioma two immort glioblastoma cultiv carri adher cultur neurospher ns condit compar transcriptom monolay ml ns cell cultur use enrichr gene set enrich analysi describ transcript factor tfs pathway involv format glioma ns observ ns format accompani activ five common glioma tfs sox ubtf nfel tcf stat set transcript control tfs myc max suppress ns upregul gene involv process epitheli mesenchym transit cancer stem invas migrat glioma cell howev mycmax depend downregul gene involv translat focal adhes apic junction furthermor found three egfr fgfr signal feedback regul common analyz glioma spri errfi rab use creat new therapeut strategi suppress invas progress glioma | D005910;D059467 | T191;T081;T086 |
36,231,067 | applic lacunar quantif singl molecul local microscopi imag quantit analysi dataset achiev singl molecul local microscopi vital studi structur subcellular organ cluster analysi emerg multi facet tool structur analysi local dataset howev result produc great depend set paramet process comput intens present new approach structur analysi use lacunar unlik cluster analysi lacunar calcul quick provid definit inform structur local use simul data demonstr lacunar result interpret use interpret compar lacunar analysi previous cluster analysi base result field dna repair show new algorithm effici | D008853;D000072760 | T059 |
36,231,066 | prolong antiretrovir treatment induc adipos tissu remodel associ mild inflamm siv infect macaqu chronic sivhiv infect adipos tissu target antiretrovir treatment art virus might subsequ contribut low grade system inflamm observ patient art evalu inflammatori profil chronic sivhiv infect assay subcutan viscer abdomin non infect siv control art nave siv infect siv art control siv infect sivart cynomolgus macaqu mrna express gene code factor relat inflamm signific differ observ compar sivart group siv andor siv group art treat infect impact metabol fraction elev express ppar cebp extracellular matrix elev express cola hif inflammatori profil pro anti inflammatori signatur detect greater mrna express anti inflammatori marker adiponectin cd marker associ inflamm tnf mx ccl cxcl intergroup differ marker il mcp conclus observ mark differ immun metabol profil context art treat chronic siv infect differ relat art siv infect per se | D015658;D016097;D015302 | T047;T005 |
36,231,065 | exosom plasminogen activ inhibitor induc ioniz radiat adapt glioblastoma cachexia cancer cachexia muscl wast syndrom lead sever compromis qualiti life increas mortal strong associ cachexia poor prognosi demonstr intract cancer includ glioblastoma gbm present studi demonstr ioniz radiat ir first line treatment gbm caus cancer cachexia increas exosom releas plasminogen activ inhibitor pai glioblastoma cell exosom pai deliv skelet muscl direct penetr muscl phosphoryl stat intensifi muscl atrophi activ muscl ring finger protein murf muscl atrophi f box atrogin furthermor hamper muscl protein synthesi inhibit mtor signal addit pharmacolog inhibit pai tm inhibit muscl atrophi rescu muscl protein synthesi therebi provid surviv benefit gbm orthotop xenograft mous model summari data delin role pai induct gbm cachexia associ radiotherapi treat gbm data also indic target pai could serv attract strategi manag gbm follow radiotherapi would lead consider improv qualiti life gbm patient undergo radiotherapi | D002100;D005909 | T191;T184 |
36,231,064 | reprogram cell metabol better anti tumor immun cell play central role anti tumor immun whose activ differenti profound regul intrins metabol reprogram emerg evid reveal metabol process cell general alter tumor cell tumor releas factor lead crippl anti tumor immun therefor better understand cell metabol mechan crucial develop next generat cell base anti tumor immunotherapeut review discuss metabol pathway affect cell exert anti tumor effect remodel metabol program improv cell mediat anti tumor immun respons emphas glycolysi carboxyl acid cycl fatti acid oxid cholesterol metabol amino acid metabol nucleotid metabol work togeth tune tumor reactiv cell activ prolifer | D009369;D013601 | T191;T025 |
36,231,063 | advanc concentr gradient generat approach microfluid devic toxic analysi systemat review aim analyz develop function microfluid concentr gradient generat cggs toxicolog evalu differ biolog organ search articl use keyword concentr gradient generat toxic microfluid devic articl found includ examin regard fabric microdevic characterist cgg biolog model desir result main fabric method soft lithographi use polydimethylsiloxan pdms materi su mold new technolog appli minim shear bubbl problem reduc cost acceler prototyp christma tree cgg design variat report studi well convect method generat biolog model includ bacteria nematod antibiot screen microalga pollut toxic tumor normal cell primarili chemotherapi screen zebrafish embryo drug metal development toxic toxic effect concentr generat evalu most imag microscopi techniqu studi show advantag cggs techniqu applic sever biolog model even soft lithographi pdms christma tree popular respect categori current studi aim appli new technolog intric architectur improv test effect reduc common microfluid problem allow high applic toxic test differ medic environment model | D004785;D056656 | T075;T131 |
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