PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,231,062 | effect noonan syndrom germlin mutat mitochondria energi metabol noonan syndrom ns relat noonan syndrom multipl lentigin nsml contribut pathogenesi human diseas rasopathi famili famili genet disord constitut one largest group development disord variabl penetr sever associ distinct congenit disabl includ facial featur cardiopathi growth skelet abnorm development delayment retard tumor predisposit ns first clinic describ decad ago sever gene sinc identifi provid molecular foundat understand physiopatholog identifi target therapeut strategi gene encod protein particip regul rasmapk signal ras pathway regul cellular metabol control mitochondri homeostasi dynam energi product howev littl known role mitochondri metabol ns nsml manuscript comprehens review frequent mutat gene respons ns nsml cover role current knowledg cellular signal pathway focus pathophysiolog outcom mitochondria energi metabol | D044542;D009634 | T047;T019 |
36,231,061 | illustr gut thyroid axi alcohol use disord interplay gut dysfunct pro inflammatori respons thyroid function background heavi chronic alcohol drink lead alter gut dysfunct coupl pro inflammatori state thyroid associ hormon protein may dysregul heavi chronic alcohol intak howev mechan alter gut deriv chang thyroid function studi thus far studi investig role alcohol induc gut dysfunct pro inflammatori cytokin profil thyroid function patient alcohol use disord aud method male femal aud patient n divid gr patient normal thyroid stimul hormon tsh level n tsh miul gr patient clinic elev tsh level n tsh gt miul demograph drink measur comprehens metabol panel candid thyroid marker tsh circul triiodothyronin free thyroxin ft analyz gut dysfunct associ marker lipopolysaccharid lps lps bind protein lbp solubl lps induc pathogen associ protein scd candid pro inflammatori cytokin il tnf il il mcp pai also evalu result patient group present borderlin overweight bmi categori gr report numer higher indic chronic heavi drink pattern gr ft level elev within normal limit group gut dysfunct marker lbp scd numer elev gr vs gr suggest subtl ongo chang candid pro inflammatori cytokin signific elev gr includ il mcp pai gr show strong statist signific effect gut immun thyroid respons r p tsh level multivari regress model lbp scd pai level upstream variabl gut thyroid pathway addit auroc analysi demonstr mani cytokin strong predict tsh gr includ il area p lt tnf area p among other observ gr gr demonstr elev ft well tsh suggest subclin thyroid under cns dysfunct lack negat feedback loop conclus find reveal toxic effect heavi chronic drink play patholog role thyroid gland dysregul employ gut brain axi result also emphas potenti direct care evalu thyroid dysregul overal medic manag aud | D000437;D007422;D013961 | T023;T048 |
36,231,060 | runx famili hypox microenviron angiogenesi cancer tumor microenviron tme broad implic tumorigenesi tumor cell interact surround cell influenc develop progress tumor blood vessel major compon tme attribut creation hypox microenviron common featur advanc cancer inflam premalign tissu runt relat transcript factor runx protein transcript factor famili development master regul involv vital cellular process differenti prolifer cell lineag specif apoptosi furthermor runx famili involv regul various oncogen process signal pathway well tumor suppress function suggest runx famili play strateg role tumorigenesi review discuss relev find describ crosstalk runx famili hypox tme tumor angiogenesi signal molecul cancer develop progress | D050657;D009369 | T191;T123;T116 |
36,231,059 | interplay cellular respons dna doubl strand break estrogen cancer develop often connect impair dna repair dna damag signal pathway presenc dna damag cell activ dna damag respons complex cellular signal network includ dna repair activ cell cycl checkpoint cellular senesc apoptosi dna doubl strand break dsbs toxic lesion main repair non homolog end join homolog recombin repair hrr pathway estrogen depend cancer like breast ovarian cancer frequent associ mutat gene play role hrr femal sex hormon estrogen bind activ estrogen receptor er er er g protein coupl er gper er drive prolifer er inhibit cell growth estrogen regul transcript stabil activ numerus ddr factor ddr factor turn modul er express stabil transcript activ addit estrogen stimul dsb format cell part metabol prolif effect review present overview crosstalk estrogen cellular respons dsbs discuss estrogen regul dsb signal repair ddr factor modul express stabil activ estrogen also discuss regul hrr gene estrogen promot develop estrogen depend cancer | D053903;D009369 | T191;T049 |
36,231,058 | nose brain next step stem cell biomateri therapi neurolog disord neurolog disord lead caus morbid worldwid give rise grow need develop treatment revert symptom review highlight great potenti recent advanc cell therapi treatment neurolog disord administr pluripot stem cell novel therapi may promot neuroprotect neuroplast neuroregener lesion area review also address administr therapeut molecul intranas rout promis non convent rout allow direct access central nervous system without cross blood brain barrier avoid potenti advers reaction enabl administr larg quantiti therapeut molecul brain final focus need use biomateri play import role nutrient carrier scaffold immun modul administr non autolog cell littl research conduct integr biomateri alongsid intranas administ cell therapi high promis approach treatment neurolog disord | D001672;D009422 | T047;T122 |
36,231,057 | mir regul tcp modul siliqu develop associ seed shatter brassicacea seed shatter undesir trait lead crop yield loss improv siliqu resist shatter critic grain oil crop studi found mir target teosint branch cycloidea prolifer cell nuclear antigen bind factor tcps inhibit process post fertil fruit siliqu elong dehisc via regul fruitful ful express arabidopsi thaliana brassica napus atmira activ result longer siliqu thicken lignifi replum wherea overexpress mira resist version attcp mtcp led short siliqu narrow less lignifi replum genet expression analysi suggest ful act downstream tcp negat regul siliqu develop moreov hyper activ bntcpa b napus homolog attcp rapese result enhanc siliqu resist shatter due attenu replum develop taken togeth find advanc knowledg tcp regul siliqu develop provid potenti target genet manipul reduc siliqu shatter brassica crop | D017360;D029681;D001937;D029688;D035683 | T116;T002;T123;T168;T114 |
36,231,056 | combin paclitaxel pxr antagonist spa revers paclitaxel resist non small cell lung cancer paclitaxel ptx one effici drug late stage non small cell lung cancer nsclc patient howev patient gradual develop resist ptx long term treatment identif new strategi revers ptx resist nsclc crucial import treatment ptx agonist pregnan x receptor pxr regul ptx metabol antagon pxr therefor may render nsclc sensit ptx treatment studi investig pxr antagonist spa role ptx treatment nsclc vitro spa ptx synergist inhibit cell growth migrat invas paclitaxel sensit paclitaxel resist h lung cancer cell mechanist found ptx spa cotreat disassoci pxr abcb mdr p gp promot thus inhibit p gp express furthermor combin regimen synergist enhanc interact pxr tip abrog tip mediat tubulin acetyl lead mitosi defect phase arrest necroptosisapoptosi combin pxt spa dramat inhibit tumor growth paclitaxel resist atr xenograft tumor model taken togeth show spa reduc paclitaxel resist nsclc combin regimen ptx spa could potenti novel candid treatment taxan resist lung cancer | D002289;D008175 | T191 |
36,231,055 | biochem pathway cellular mechanosensingmechanotransduct role neurodegen diseas pathogenesi review shed light recent advanc regard character biochem pathway cellular mechanosens mechanotransduct particular attent role neurodegen diseas pathogenesi mechanist compon pathway most uncov today crosstalk mechan forc solubl intracellular signal still fulli elucid recapitul general concept mechanobiolog mechan govern mechanosens mechanotransduct process examin crosstalk mechan stimuli intracellular biochem respons highlight effect cellular organell homeostasi dysfunct particular discuss current knowledg translat mechanosign biochem signal focus diseas encompass metabol accumul mutant protein primari characterist format patholog intracellular aggreg alzheim diseas huntington diseas amyotroph later sclerosi parkinson diseas overal recent find elucid mechanosens mechanotransduct pathway may crucial understand pathogen mechan under neurodegen diseas emphas import pathway identifi potenti therapeut target | D000544;D019636;D010300 | T047;T048 |
36,231,054 | antagon cgrp receptor central peripher mechan mediat anim model chronic migrain calcitonin gene relat peptid cgrp play key role migrain pathophysiolog specif mechan under peripher central sensit explor interact cgrp pain mediat relev neuron sensit anim model chronic migrain male spragu dawley rat expos nitroglycerin ntg mgkg ip vehicl co administ cgrp receptor antagonist olcegep mgkg ip vehicl everi day day period twenti four hour last inject ntg vehicl behavior test ex vivo analysi perform olcegep attenu ntg induc trigemin hyperalgesia second phase orofaci formalin test interest also reduc gene express protein level cgrp pro inflammatori cytokin inflammatori associ mirna mir p mir p mir p transient receptor potenti ankyrin channel medulla pon area cervic spinal cord trigemin ganglia similar olcegep reduc ntg induc increas cgrp inflammatori cytokin serum find show activ cgrp pathway migrain anim model associ persist activ inflammatori pathway parallel condit hyperalgesia molecular event relev inform us mechan under chronic migrain | D035683;D008881 | T047;T123;T114 |
36,231,053 | gut microbiota nutrit health special focus specif bacteri cluster health influenc gut microbiom develop result extern intern factor nutrit environ medic use age sex genet alpha beta divers metric enterotyp cluster method common employ perform popul studi analys effect various treatment yet continu develop new sequenc technolog various omic field result becom access investig increas sophist methodolog need inde develop order disentangl complex way gut microbiom health intertwin diseas affluenc type diabet td cardiovascular diseas cvd common link speci associ bacteroid enterotyp declin various benefici complex microbi trophic network turn link aforement factor review explor effect common intern extern factor gut microbiom composit turn relat td cvd discuss research opportun enabl limit latest technic develop microbiom sector includ use artifici intellig ai strain track peak trough ratio | D002318;D003924;D000069196 | T007;T001;T047 |
36,231,052 | novel missens mutat ercc co segreg cerebellar ataxia consanguin pakistani famili autosom recess cerebellar ataxia arca heterogen rare disord main affect cerebellum manifest movement disord children young adult date arca caus mutat identifi near gene howev account less case studi multiplex consanguin pakistani famili present slowli progress gait ataxia bodi imbal dysarthria cerebellar atrophi identifi magnet reson imag brain use whole exom sequenc novel homozyg missens mutat ercc ct gt c pmt identifi co segreg diseas previous studi identifi homozyg mutat ercc causal cockayn syndrom type csa uv light sensit syndrom sever arca ercc play critic role nucleotid excis repair complex pmt substitut mutat locat high conserv wd beta transducin repeat motif silico model show structur protein signific affect pmt mutat like impair complex format protein protein interact cultur cell pmt mutat signific lower protein stabil compar wildtyp ercc protein find expand role ercc mutat arca indic ercc relat mutat consid differenti diagnosi arca | D002524 | T047;T184;T033 |
36,231,051 | supramolecular hydrogel wrap gingiv mesenchym stem cell cutan radiat injuri radiat induc skin wounddermat one common side effect radiotherapi intervent radiobiolog gingiva deriv mesenchym stem cell gmscs indic therapeut potenti skin diseas howev stem cell prone spread difficult stay skin long time limit curat effect applic studi investig therapeut efficaci nap gdfdfpdi py gel self assembl peptid hydrogel encapsul gmscs treat cs radiat induc skin wound mice effect evalu skin damag score hind limb extens measur histolog immunohistochem analysi vivo studi show py gel self assembl peptid hydrogel encapsul gmscs could effect improv wound heal irradi skin tissu addit found gmscs condit medium cm could promot prolifer migrat dna damag repair abil skin cell irradi human keratinocyt cell line hacat normal human dermal fibroblast hff mechanist gmscs cm promot express epiderm growth factor receptor egfr signal transduc activ transcript stat matrix metalloproteinas mmps suggest activ egfrstat signal pathway may involv repair skin cell exposur radiat conclus py gel self assembl peptid hydrogel encapsul gmscs benefici therapeut effect radiat induc cutan injuri may serv basi novel cell therapeut approach | D059630;D011832 | T025;T037;T047 |
36,231,050 | proteom phosphoproteom profil reveal oncogen role protein kinas famili kinas cholangiocarcinoma cholangiocarcinoma cca lethal malign hepatobiliari system dysregul protein express phosphoryl signal howev protein phosphoryl signatur ccas littl known perform proteom phosphoproteom profil tumor normal adjac tissu nat patient cca predict eleven pks high potenti relat cca comprehens infer function protein kinas pks cifpk pipelin besid two known cca associ pks screen remain candid uncov five pks novel regul cca specif protein kinas pkd famili member includ prkd prkd prkd identifi critic regul cca moreov pan inhibitor pkd famili naphthyl pp na pp valid potent agent inhibit prolifer migrat invas abil cca cell studi reveal new pks associ cca suggest prkd kinas novel treatment target cca | D001650;D018281 | T191 |
36,231,049 | influenc shear stress inflamm brd inhibit human endotheli cell holist proteom approach atherosclerosi import risk factor develop cardiovascular diseas addit increas plasma lipid concentr irregularoscillatori shear stress inflammatori process trigger atherosclerosi inhibitor transcript modulatori bromo extra termin domain bet protein famili beti could offer possibl therapeut approach due epigenet mechan anti inflammatori properti studi influenc laminar shear stress inflamm beti treatment human endotheli cell investig use global protein express profil ion mobil separ enhanc data independ acquisit mass spectrometri im dia ms purpos primari human umbil cord deriv vascular endotheli cell treat tnf mimic inflamm expos laminar shear stress presenc absenc brd inhibitor jq im dia ms detect protein express endotheli cell inflamm shear stress beti led pronounc chang protein express pattern jq greatest effect knowledg first proteom studi primari endotheli cell provid extens databas effect shear stress inflamm beti endotheli proteom | D050197;D042783 | T047;T046;T025 |
36,231,048 | impact activ base intervent neuropath pain experiment spinal cord injuri physic activ base rehabilit intervent repres main treatment concept peopl suffer spinal cord injuri sci role intervent play relief neuropath pain np state emerg along under mechan result sci induc np sci np anim model use investig benefit activ base intervent abi treadmil train wheel run walk swim biped stand activ base paradigm shown modul inflammatori relat alter well induc function structur chang spinal cord gray matter circuitri correl pain behavior thus far research avail provid incomplet pictur cellular molecular pathway involv benefici effect continu research essenti understand intervent benefit sci patient suffer np allow develop individu rehabilit therapi articl review preclin studi specif topic goe mechan involv sci np relat abi discuss effect differ activ base paradigm relat differ form intens initi time durat abi articl also summar mechan respect intervent amelior np sci provid suggest futur research direct | D009437;D013119 | T047;T184;T037 |
36,231,047 | function divers neuron cell adhes recognit molecul lcam proteolyt cleavag neuron cell adhes recognit molecul l keep cell togeth way homophil heterophil interact also promot cell motil cleav fragment sever proteas larg thought fragment sign degrad clear proteolysi contribut pronounc function divers l review work l fragment generat plasma membran releas extracellular space wherea membran bound fragment internalis enter nucleus thus convey extracellular signal cell interior post translat modif l determin sequenc cleavag proteas subcellular localis generat fragment insid neuron cell l fragment interact various bind partner facilit morphogen event well regen process stimul l proteolysi via inject l peptid proteas activ l l mimet promis tool therapi injur nervous system collect find gather year shed light great function divers l fragment also provid novel mechanist insight adhes molecul proteolysi activ develop diseas nervous system | D039842 | T123;T116 |
36,231,046 | endotheli nogo b suppress cancer cell prolifer via paracrin tgf smad signal nogo b report play critic role angiogenesi repair damag blood vessel howev role tumor microenviron remain unclear observ differenti express nogo b endotheli cell hepatocellular carcinoma hcc glioma sampl downregul nogo b express correl malign phenotyp cancer poor prognosi patient subsequ studi endotheli nogo b inhibit robust promot growth hcc glioma xenograft nude mice intrigu endotheli nogo b silenc dramat suppress endotheli cell expans tumor angiogenesi potent enhanc prolifer neighbor hcc glioma cell base result elisa assay nogo b silenc reduc tgf product endotheli cell attenu phosphoryl nuclear transloc smad neighbor cancer cell endotheli nogo b silenc mediat increas cancer cell prolifer abolish either tgf neutral antibodi tgf receptor inhibitor indic essenti role tgf endotheli nogo b mediat suppress cancer growth find broaden understand crosstalk cancer cell endotheli cell also provid novel prognost biomark therapeut target cancer treatment | D006528;D005910;D008113 | T191 |
36,231,045 | clinic prognost valu ppia sqstm ccl hepatocellular carcinoma patient singl cell transcriptom analysi hepatocellular carcinoma hcc malign poor prognosi subtyp primari liver cancer scrna seq approach provid uniqu insight tumor cell behavior singl cell level cytokin signal immun system play import role tumorigenesi pro tumorigen anti tumorigen function biomark cytokin signal immun relat gene csirg urgent requir assess hcc patient diagnosi treatment analyz express profil hcc singl cell tcga icgc data discov three import csirg ppia sqstm ccl link overal surviv hcc patient cancer status three hub csirg taken account creat risk nomogram nomogram high level predict accuraci base csirg risk score distinct pattern somat tumor mutat burden tmb detect two group enrich pyrimidin metabol pathway purin metabol pathway lysosom pathway hcc link csirg high risk score overal scrna seq bulk rna seq use creat strong csirg signatur hcc diagnosi | D006528;D008113 | T191 |
36,231,044 | disrupt optic atrophi opa contribut cell death hl cardiomyocyt subject lethal ischemia reperfus injuri disrupt mitochondri structurefunct well recogn determin cell death cardiomyocyt subject lethal episod ischemia reperfus ir howev precis mitochondri event precipit lethal ir injuri remain incomplet resolv use vitro hl cardiomyocyt model aim establish whether proteolyt process optic atrophi protein opa inner mitochondri membran protein respons maintain crista junction integr play causal mechanist role determin cardiomyocyt fate cell subject lethal ir injuri preserv opa may contribut well document cardioprotect achiev ischem precondit ipc remot ischem condit report hl cell subject h simul ischemia display increas activ oma metalloproteas respons proteolyt process opa initi min follow reoxygen accompani process mitochondri opa ie cleavag yield short opa peptid releas short opa cytosol howev sirna mediat knockdown opa content exacerb lethal ir injuri attenu cardioprotect seen ipc remot precondit stimulus achiev transfer reperfus medium trm ipc cell cultur model taken togeth result support concept mainten opa integr play mechanist role determin cell fate hl cardiomyocyt model lethal ir injuri preserv opa under cardioprotect seen ischem condit | D009896;D015427 | T047;T037 |
36,231,043 | morpholog phagophor precursor correl light electron microscopi autophagosom biogenesi occur transient subdomain endoplasm reticulum call omegasom fluoresc microscopi appear small puncta grow diamet final shrink disappear autophagosom complet autophagosom form phagophor membran cistern elong close form doubl membran limit autophagosom earlier electron microscopi studi show elong phagophor line endoplasm reticulum side howev morpholog earli phagophor precursor studi electron microscopi level use live cell imag cell express marker phagophor biogenesi combin correl light electron microscopi well electron tomographi atgab doubl defici cell reveal high resolut morpholog phagophor precursor three dimens show phagophor close near close autophagosom alreadi stage omegasom diamet still larg observ phagophor precursor emerg next endoplasm reticulum bud like high curv membran cistern small open cytosol phagophor precursor open form flat cistern elong curv form classic describ crescent shape phagophor | D000071182;D004583 | T026;T196;T081 |
36,231,042 | comprehens profil cellular sphingolipid mammalian endotheli microgli cell cultur normal high glucos condit sphingolipid spls play divers role maintain cellular homeostasi dysregul spl metabol associ patholog chang stress diseas cell studi investig differ spl metabol cultur human primari retin endotheli hrec murin microgli cell bv normal condit normal glucos ng mm high glucos hg mm induc stress sphingolipidom immunohistochemistri biochem molecular assay measur differ observ spl profil hrec bv cell high glucos treatment caus gt fold increas level lactosyl ceramid laccer hrec bv cell induc hexosyl ceramid hexcer threefold signific increas sphingosin phosphat sp compar ng alter spl profil coincid chang transcript level inflammatori vascular permeabl mediat hrec inflammatori mediat bv cell differ spl profil differenti respons hg stress endotheli microgli cell suggest spl metabol signal differ mammalian cell type therefor patholog associ cell type | D017628;D013107 | T025;T109 |
36,231,041 | f nos pet brain imag suggest elev neuroinflamm idiopath parkinson diseas neuroinflamm implic key patholog mechan mani neurodegen diseas thought mediat larg part microglia nativ phagocyt immun cell cns abnorm aggreg protein synuclein phagocytosi microglia one possibl neuropathophysiolog mechan drive parkinson diseas pd conduct human pilot studi evalu feasibl target induc isoform nitric oxid synthas use f nos radiotrac measur neuroinflamm idiopath pd ten adult consist pd patient healthi control hc underw one hour dynam f nos positron emiss tomographi pet brain imag arteri blood sampl observ increas f nos whole brain distribut volum v pd patient compar age match healthi control p lt via tissu compart tc model rate constant k transport blood tissu differ group p find suggest elev oxid stress surrog marker inflamm present earli stage idiopath pd indic f nos pet imag promis non invas method measur neuroinflamm | D010300 | T047 |
36,231,040 | technolog enabl singl molecul super resolut imag mrna transient natur rna render one difficult biolog target imag difficulti stem physic properti rna well tempor constraint associ therewith concern complic difficulti imag endogen rna within cell transfect target sequenc concern combin tradit concern associ super resolut light microscopi made imag critic target difficult recent advanc provid research tool imag endogen rna live cell cellular singl molecul level review techniqu use label imag rna special emphas various label method virtual super resolut imag techniqu | D021621;D000072760 | T059;T062;T073;T060 |
36,231,039 | ca mediat switch epiplakin diffus keratin bound state affect keratin dynam keratin exert import structur also cytoprotect function adapt support cellular homeostasi epiplakin eppk shown decor keratin filament epitheli cell play protect role stress mechan still unclear use live cell imag epitheli cell express fluoresc tag eppk keratin report unexpect dynam behavior eppk upon stress eppk diffus distribut throughout cytoplasm associ keratin filament live cell standard cultur condit howev er oxid uv stress well cell fixat induc rapid associ eppk keratin filament local eppk revers depend elev cytoplasm ca level moreov keratin filament associ eppk led signific reduc keratin dynam thus propos eppk stabil keratin network stress condit involv increas cytoplasm ca | D003599;D007633 | T026;T123;T116 |
36,231,038 | baicalin modul inflammatori respons macrophag activ lps via calcium chop pathway studi natur product allevi inflammatori respons macrophag caus endotoxin lipopolysaccharid continu studi investig anti inflammatori activ baicalin relat macrophag activ caus lipopolysaccharid lps baicalin flavon glycosid found plant scutellaria baicalensi scutellaria lateriflora belong genus scutellaria multiplex cytokin assay mca griess reagent assay fluo calcium assay dihydrorhodamin dhr assay quantit rt pcr flow cytometri perform use raw mous macrophag mca reveal baicalin signific decreas product interleukin il granulocyt coloni stimul factor g csf vascular endotheli growth factor vegf macrophag inflammatori protein mip mip mip rant lps stimul raw macrophag concentr dhr assay show baicalin signific inhibit reactiv oxygen speci generat lps stimul raw macrophag flow cytometri reveal baicalin signific reduc level phosphoryl p mapk fas lps stimul raw macrophag baicalin also inhibit mrna express level inflammatori gene chop fas nos ptgs stat c jun c fos ata ic valu baicalin il tnf g csf vegf interferon gamma induc protein ip leukemia inhibitori factor lif lipopolysaccharid induc cxc chemokin lix mip mip mip rant nitric oxid intracellular calcium hydrogen peroxid respect baicalin modul inflammatori respons macrophag activ lps via calcium chop pathway | D001688;D047309 | T121;T109;T123 |
36,231,037 | calcium sens receptor casr mediat intracellular communic cardiovascular diseas calcium sens receptor casr g protein coupl receptor gpcr cell surfac locat receptor induc high diffus messeng ip ca camp cytoplasm activ various cellular respons recent also suggest casr mediat intracellular communic endoplasm reticulum er mitochondria nucleus proteaseproteasom autophagi lysosom involv relat cardiovascular diseas complex intracellular signal receptor challeng valuabl therapeut target therefor necessari understand mechan behind signal characterist receptor intracellular communic review provid overview recent research progress various regulatori mechan casr relat cardiovascular diseas heart kidney interact associ common caus also discuss | D002318;D044169 | T047;T116;T192 |
36,231,036 | emerg role clinic potenti circsmarca cancer circular rnas circrna type endogen non code rna critic epigenet regul way close loop structur high stabl conserv tissu specif play import role develop mani diseas includ tumor neurolog diseas cardiovascular diseas circsmarca circrna form parent gene smarca via back splice dysregul express varieti tumor involv tumor develop dual function oncogen tumor suppressor serv compet endogen rna cerna bind various mirna also interact rna bind protein rbp regul downstream gene express also aid dna damag repair regul transcript express parent gene review systemat summar express characterist dual biolog function molecular regulatori mechan circsmarca involv carcinogenesi tumor progress well potenti applic earli diagnosi gene target therapi tumor | D035683;D009369 | T191;T123;T114 |
36,231,035 | novel gata variant caus bleed phenotyp associ combin platelet storag pool defici mild dyserythropoiesi modifi slca variant germlin defect transcript factor gata known caus dyserythropoiesi anemia variabl abnorm platelet count function howev damag variant close locat c termin zinc finger domain gata near unknown studi year old male index patient year old daughter suffer moder mucocutan bleed diathesi sinc birth whole exom sequenc detect novel hemizyg gata missens variant ca gt c ptp locat c termin zinc finger nuclear local sequenc non random x chromosom inactiv heterozyg daughter blood smear patient demonstr larg platelet fraction moder thrombocytopenia index flow cytometri electron microscopi analysi support combin subtyp storag pool defici caus impair agonist induc platelet aggreg light transmiss aggregometri granul exocytosi flow cytometri absenc bcam index lu b low express daughter lu b confirm less obvious effect defect gata also erythrocyt borderlin anemia elev hbf level differenti transcript gata regul gene indic mild dyserythropoiesi patient furthermor mild slca defect associ heterozyg slca cc gt pav variant matern transmit daughter may modifi diseas mild spherocytosi hemolysi | D000740;D010981 | T047 |
36,231,034 | immun regen respons burn injuri burn divers complex injuri local effect also serious system consequ sever prolong inflammatori respons caus heat electr friction chemic radiat common divid superfici superfici partial deep partial full thick injuri sever burn depend main size depth injuri also locat age under system diseas prolong strong immun respons make major burn even wors caus multipl system effect includ damag heart lung blood vessel kidney organ burn requir surgic excis superfici superfici partial thick follow known progress wound heal inflamm prolifer remodel whilst deep partial full thick injuri requir excis graft burn intervent requir optim coverag function cosmesi annual million peopl worldwid suffer burn associ high morbid mortal fortun past decad burn care signific improv improv understand pathophysiolog burn injuri burn wound progress led develop skin graft fluid resuscit infect control nutrit review articl focus immun regen respons follow burn injuri introduct describ epidemiolog burn burn pathophysiolog focus follow chapter system respons burn injuri next defin immun respons burn introduc differ cell type involv subsequ discuss regen cell respons burn well emerg novel treatment battl burn | D002056 | T037 |
36,231,033 | increas adipos tissu express il associ inflammatori marker peopl high ldl cholesterol chronic low grade inflamm induc obes central risk factor develop metabol syndrom high low densiti lipoprotein cholesterol ldl c induc inflamm common denomin metabol syndrom il play signific role pathogenesi meta inflammatori diseas howev relationship ldl c remain elus cross section studi determin whether adipos tissu il express associ inflammatori mediat peopl increas plasma ldl c concentr subcutan adipos tissu biopsi collect peopl sub divid two group base plasma ldl c concentr lt mmoll adipos express il inflammatori marker determin use real time qrt pcr plasma concentr total cholesterol tc triglycerid tg high densiti lipoprotein cholesterol hdl c ldl c determin use standard method adiponectin level measur enzym link immunosorb assay elisa adipos il transcript found increas peopl high ldl c compar low ldl c group h ldl c fold l ldl c fold p lt il correl posit ldl c r p lt immunochemistri analysi show il protein express also elev peopl h ldl c il express high ldl c group associ multipl adipos inflammatori biomark p includ macrophag marker cdc cd cd cd tlrs tlr tlr irf pro inflammatori cytokin tnf il il chemokin cxcl ccl ccl ccl ccl notabl cohort il express correl invers plasma adiponectin conclus adipos il may inflammatori biomark diseas progress peopl high ldl c | D006949;D024821 | T047;T033 |
36,231,032 | effect endochondr intramembran ossif pathway bone tissu format vascular human tissu engin graft bone graft engin differenti human mesenchym stromal cell mscs via endochondr intramembran ossif pathway evalu effect pathway properti engin bone graft capac drive bone regener bone marrow deriv mscs differenti silk scaffold either hypertroph chondrocyt hyper osteoblast osteo week vitro cultiv implant subcutan week pathway construct evalu time respect gene express composit histomorpholog microstructur vascular biomechan hypertroph chondrocyt express higher level osteogen gene deposit signific bone miner protein osteoblast implant miner hyper group less matur osteo group follow week implant hyper group increas miner densiti similar overal miner composit compar osteo group hyper group also display signific blood vessel infiltr osteo group group contain macrophag indic bone regener data suggest similar bodi repair process endochondr pathway might advantag regener larg defect wherea intramembran ossif could util guid tissu format pattern scaffold architectur | D059630;D010012 | T025;T042 |
36,231,031 | krppel like factor pivot gene regul erythropoiesi krppel like factor klf play crucial role erythropoiesi depth studi conduct mice human highlight import erythroid lineag commit termin erythropoiesi progress switch globin gene role klf haemoglobin switch exert direct activ globin gene silenc globin activ bcla import globin gene repressor link klf globin silenc identifi transcript factor possibl therapeut target hemoglobinopathi moreov sever mutat identifi human gene respons various benign phenotyp erythroid disord studi phenotyp associ mutat great contribut current understand complex role klf erythropoiesi review focus princip function klf erythroid cell commit differenti span primit definit erythropoiesi fundament role klf haemoglobin switch also highlight final overview princip human mutat relat phenotyp disord describ | D004920;D055545 | T042;T123;T116 |
36,231,030 | pancreat ductal adenocarcinoma molecular patholog predict biomark pancreat ductal adenocarcinoma pdac extrem poor prognosi due lack method biomark earli diagnosi resist convent treatment modal target therapi immunotherapi pdac heterogen group malign epitheli neoplasm various histomorpholog pattern complex heterogen geneticmolecular landscap newli propos molecular classif pdac base extens genom transcriptom proteom epigenet data provid signific insight molecular heterogen aggress biolog dead diseas recent studi character tumor microenviron tme shed light dynam interplay tumor cell immunosuppress tme pdac essenti diseas progress well resist chemotherapi newli develop target therapi immunotherapi critic need develop predict marker clinic util select effect person therapi pdac patient review provid overview histolog molecular heterogen subtyp pdac well precursor lesion immunosuppress tme current avail predict molecular marker patient | D021441;D010190 | T191 |
36,231,029 | silenc adipocytokin nov novel approach revers oxid stress induc cardiometabol dysfunct novccn adipocytokin recent link obes insulin resist cardiometabol dysfunct nov manufactur secret adipos tissu blood level high correl bmi nov level increas obes myriad inflammatori diseas elev nov level caus oxid stress increas free radic decreas antioxid decreas heme oxygenas ho level result decreas vascular function silenc nov nov knockout mice improv insulin sensit want studi suppress nov express obes anim model affect pathway process relat obes inflamm cardiometabol function first studi investig interact adipos tissu specif novccn cardiometabol function | D002318;D007333;D061385 | T121;T047;T046 |
36,231,028 | hyaluron acid coat bovin milk exosom achiev tumor specif intracellular deliveri mirna cell type specif drug deliveri straightforward strategi achiev target cancer therapi reduc side effect hyaluron acid ha us food drug administr fda approv biocompat carbohydr polym extens employ target ligand drug deliveri system due natur abil bind tumor cell overexpress cluster differenti cd receptor report prepar antitumor efficaci ha coat bovin milk exosom ha mexo tumor specif deliveri microrna p mimic mir exosom base deliveri formul prepar mir encapsul insid lumen ha display outsid membran result formul ha mexo mir abl specif target cd posit cancer cell concomit increas intracellular uptak mir compar uncoat mexo mir formul ha mexo mir show signific increas antitumor efficaci vitro vivo import ha mexo mir show excel biocompat caus signific system toxic given ha bovin milk exosom low cost high access biogen materi broad biomed applic ha decor bovin milk exosom proven practic drug deliveri system rna drug target cancer therapi | D055354;D035683;D009369 | T191;T026;T123;T114 |
36,231,027 | cuedc drive catenin nuclear transloc promot tripl negat breast cancer tumorigenesi hyperactiv wnt signal crucial tumor format fulli elucid molecular detail cancer specif wnt signal pathway activ contribut tumorigenesi help determin futur treatment strategi aim explor contribut cuedc novel cue domain contain protein activ wnt signal tumorigenesi tripl negat breast cancer tnbc determin under mechan tnbc patient sampl diseas free surviv dfs data use determin associ cuedc tnbc progress effect cuedc tnbc examin tnbc cell vitro subcutan xenograft tumor vivo gene knockdown immunoprecipit plus liquid chromatographi tandem mass spectrometri pull co immunoprecipit local surfac plasmon reson nuclear transloc analysi use uncov mechan cuedc regul wnt signal tnbc develop cuedc suffici maintain hyperactiv wnt signal requir tnbc tumorigenesi contribut cuedc play major role determin outcom oncogen wnt signal vitro vivo mechanist cue domain cuedc direct bound arm domain catenin promot catenin nuclear transloc enhanc express catenin target gene import amino acid competit peptid target cue domain cuedc block interact cuedc catenin abrog malign phenotyp tnbc cell vitro vivo observ tnbc patient exhibit higher level cuedc show mark hyperactiv wnt signal pathway poor clinic outcom highlight clinic relev find cuedc promot tnbc tumor growth enhanc wnt signal direct bind catenin acceler nuclear transloc target interact cuedc catenin may valuabl strategi combat tnbc | D064726;D051176 | T191;T123;T116 |
36,231,026 | role endotheli cell onset develop modul vein graft diseas endotheli cell compris intim layer vasculatur play crucial role facilit regul aspect nutrient transport vascular homeostasi inflammatori respons given import cell maintain healthi haemodynam environ dysfunct endothelium central host vascular diseas key predictor cardiovascular risk note endotheli dysfunct believ key driver vein graft diseas patholog vein graft utilis coronari arteri bypass graft surgeri develop intim hyperplasia acceler atherosclerosi result poor long term patenc rate activ denud endothelium follow surgic trauma implant graft encourag host immun inflammatori cellular differenti respons risk drive graft failur review aim provid overview current work knowledg regard role endotheli cell onset develop modul vein graft diseas well address current surgic medic manag approach aim benefici modul endotheli function improv patient outcom | D042783;D014652 | T025;T047 |
36,231,025 | pyrotinib target egfr statcd loop mediat cell viabil tsc pyrotinib irrevers pan erbb receptor tyrosin kinas inhibitor design therapi posit breast cancer inhibit epiderm growth factor receptor egfr famili effici select suppress prolifer human tsc defici smooth muscl cell revers lung chang lamtsc pilot studi indic pyrotinib dramat restrain vital tsc defici cell compar limit impact tsc express cell pyrotinib induc g phase arrest trigger apoptosi block abnorm activ cd tsc defici cell cd import immun checkpoint also involv regul signal pathway pyrotinib inhibit nuclear import pegfr restrain pegfrpstat signal direct boost transcript express cd bind promot region revers cd enhanc pegfr function direct bind pyrotinib specif target tsc defici cell inhibit tumor cell viabil induc apoptosi egfr statcd loop vivo vitro thus pyrotinib may promis new therapeut drug tsc treatment | D066246;D047428 | T121;T126;T116;T192 |
36,231,024 | green valley drosophila amp nbsp melanogast constitut heterochromatin protein code gene involv cell divis control constitut heterochromatin repres signific fraction eukaryot genom arabidopsi human melanogast certain nematod share similar genet molecular properti anim plant speci studi conduct last year melanogast organ led discoveri sever function associ constitut heterochromatin made possibl revis concept ubiquit genom territori incompat gene express aim review focus attent group protein code gene resid melanogast constitut heterochromatin implic differ step cell divis | D004331;D006570 | T026;T204 |
36,231,023 | restor fyn level huntington diseas contribut enhanc synapt glunb compos nmda receptor creb activ n methyl aspart receptor nmdar import postsynapt receptor contribut normal synapt function cell surviv howev overactiv huntington diseas hd nmdar caus excitotox hd affect striatal neuron show alter nmdar current augment ratio surfac intern glunb contain nmdar augment accumul extrasynapt site fyn protein member src kinas famili skf import role nmdar phosphoryl synapt local function recent demonstr fyn reduc sever hd model thus studi aim explor impact hd mediat alter fyn level post synapt densiti psd role distort nmdar function local intracellular neuroprotect pathway yac mous primari striatal neuron show reduc synapt fyn level activ hd mous striatal neuron relat decreas phosphoryl synapt glunb compos nmdar occur concomit augment extrasynapt nmdar activ current reduc camp respons element bind protein creb activ along induct cell death pathway import express constitut activ form skf reestablish nmdar local phosphoryl function psd yac mous neuron enhanc skf level activ also promot creb activ reduc caspas activ yac mous striatal neuron work support first time relev role fyn protein psd modul control nmdar synapt function hd favor neuroprotect pathway cell surviv respect fyn tyr kinas constitut import potenti hd therapeut target direct act psd | D006816;D016194 | T047;T116;T192 |
36,231,022 | surgic menopaus impair retin conduct worsen prognosi acut model rat optic neuropathi defici estradiol menopaus period import risk factor neurodegen diseas includ various optic neuropathi aim studi evalu impact surgic menopaus function surviv ratio rgcs rat model onc optic nerv crush use eight week old femal long evan rat divid two main group depend time ovariectomi procedur ova euthanasia two week vs seven week subgroup ova ova onc onc retin function assess electroretinographi erg rgc loss ratio evalu use immunolabel count rgcs seven week ova menopaus morpholog affect interneuron rgc howev onc procedur appli rgcs appear suscept damag case depriv estrogen analysi phnr photop negat respons sever diminish ova onc group depriv estrogen menopaus result acceler retin neurodegener first involv retin interneuron lack estrogen increas suscept rgcs insult | D009901;D020221 | T047;T037 |
36,231,021 | rab gtpase modul vascular function rab gtpase largest famili small gtpase ubiquit express protein control various aspect cellular function cell surviv exocytosi rab cycl gdp bound inact form gtp bound activ form activ specif rab gtpase posit vesicl mediat cellular network involv intracellular traffick recycl andor exocytosi cargo protein dysfunct rab signal pathway implic various diseas process precis cellular function sever member rab gtpase famili still unknown lack pharmacolog tool lethal gene knockout made detail character protein interact network difficult nevertheless avail evid suggest protein vital normal cell function endotheli smooth muscl cell control vascular lumen diamet modul blood flow endotheli cell also secret sever pro antithrombot factor vasoact substanc coordin local inflammatori respons angiogenesi rab gtpase function endotheli cell relat well explor hand report avail protein vascular smooth muscl review summar present knowledg rab gtpase vasculatur | D042783;D020691 | T025;T126;T116 |
36,231,020 | pro inflammatori chemokin ccl cxcl cxcl bind activ platelet integrin iib alloster manner activ platelet integrin iib key event hemostasi thrombus format known mediat exclus insid signal show inflammatori chemokin cxcl cxcl previous studi ccl studi bound alloster bind site site vascular integrin v addit classic ligand bind site site alloster activ integrin independ insid signal sinc iib expos inflammatori chemokin increas concentr inflamm eg cytokinechemokin storm platelet activ hypothes chemokin bind activ iib alloster activ mechan found chemokin bound iib notabl activ solubl iib mm ca bind site activ cell surfac iib cho cell lack machineri insid signal chemokin receptor quick lt min low concentr ngml compar activ solubl iib probabl chemokin bind cell surfac proteoglycan furthermor activ iib chemokin sever time potent mm mn propos ccl cxcl store platelet granul may alloster activ iib upon platelet activ trigger platelet aggreg transmembran cxcl activ endotheli cell may mediat platelet endotheli interact bind activ iib addit chemokin circul produc inflamm may trigger iib activ possibl miss link inflamm thrombosi | D039302;D019039 | T129;T116;T192 |
36,231,019 | elucid anti tumorigen efficaci oltipraz dithiolethion glioblastoma glioblastoma multiform gbm aggress primari brain tumor display high infiltr growth pattern remain refractori chemotherapi phytochem carri specif low cytotox may serv potent safer altern convent chemotherapi treat gbm evalu anticanc effect oltipraz olt synthet dithiolethion found mani veget includ crucif olt exposur non toxic hek cell line impair cell growth three gbm cell line ln ln u mg arrest gm phase olt expos gbm cell induc generat reactiv oxygen speci ros mitochondri depolar caspas mediat apoptosi nuclear condens dna fragment decreas glutathion natur ros scaveng well vimentin catenin emt associ marker effect subpopul gbm cell exhibit glioblastoma stem cell gscs like characterist reveal reduc express oct sox cd cd decreas aldh nestin cd cell contrast increas express gfap gfap cell olt also signific suppress oncospher form abil cell efficaci valid vivo wherein oral administr olt could suppress ectop establish gbm tumor growth scid mice howev alter bodi weight organ ratio biochem paramet reflect absenc toxic otherwis togeth find could demonstr promis chemotherapeut efficaci olt potenti implic treat gbm | D005909 | T191 |
36,231,018 | magnetoreceptori function european robin retina electrophysiolog morpholog non homogen avian magnet compass allow orient migrat shown function proper short wavelength long wavelength visibl light therefor magnetorecept system assum light wavelength depend local retina eye putat candid role primari magnetosensori molecul cryptochrom known express avian retina must abl interact phototransduct protein previous report migratori bird chang magnet field direct induc signific effect electroretinogram amplitud respons blue flash effect observ nasal quadrant retina report new electroretinograph microscop microspectrophotometr data european robin confirm magnetosensit retin nasal quadrant appli background illumin hypothes magnetorecept distinct region may relat morpholog analyz retin distribut optic properti oil droplet filter structur within cone found nasal quadrant contain doubl cone intens color oil droplet compar rest retina may relat magnetosensori function | D025041;D056931 | T053;T123;T116 |
36,231,017 | mast cell interact foxp regulatori cell occur dermi initi ige mediat cutan anaphylaxi mast cell mcs well known role ige mediat cutan anaphylact respons regulatori function skin still intens scrutini use red mc basophil report rmb mous allow red fluoresc detect diphtheria toxin mediat deplet mcs investig interact mcs foxp regulatori lymphocyt treg langerhan cell lcs passiv cutan anaphylaxi pca respons use intravit imag show mcs sessil homeostasi pca breed rmb mice langerin egfp mice reveal dermal mcs interact epiderm local lcs latter show constant sprout dendrit homeostasi pca bred foxp egfp mice found although foxp treg present homeostasi mani treg transient infiltr skin pca veloc pca alter treg increas durat contact time mcs compar pca control mice antibodi mediat deplet treg effect intens pca henc observ increas treg number contact time mcs regardless effect intens pca respons suggest anti inflammatori role dedic prevent mc activ | D000707;D008407 | T047;T046;T025 |
36,231,016 | photosynthesi respons differ salin immers two nativ rhizophoracea mangrov mangrov ecosystem vulner rise sea level plant expos high salin tidal submerg way plant respond vari salin immers depth level light irradi poor studi understand photosynthesi respons salin submerg mangrov acclim differ tidal elev two year old seedl two nativ mangrov speci kandelia obovata rhizophora stylosa treat differ salin concentr part per thousand ppt without immers condit fifteen photosynthet photon flux densiti ppfd mol photonm photosynthet capac chlorophyl fluoresc chlf paramet speci measur found differ ppfds electron transport rate etr induct much faster photosynthet rate pn induct pn restrict stomat conduct gs pn immers k obovata plant increas indic speci immers toler wherea pn level r stylosa plant salt toler immers plant treat ppt salin exhibit lower pn higher non photochem quench npq heat quench valu follow increas excess energi photoprotect effect sinc npq easili measur field valu provid use ecolog monitor index may provid refer mangrov restor habitat creation ecolog monitor | D043982 | T002 |
36,231,015 | mitochondrion mediat cell death erk alox independ caspas signal mitochondri disrupt lead releas cytochrom c activ caspas downstream caspas cascad execut apoptosi howev cell death proceed effici absenc caspas follow mitochondri disrupt suggest exist caspas independ cell death mechan genom wide sirna librari screen identifi network gene mediat caspas independ cell death ros product alox depend membran lipid peroxid erk depend phosphoryl alox critic target alox nuclear membran mediat lipid peroxid result nuclear transloc cytolyt molecul induc dna damag cell death consist doubl knockout caspas alox mice delet either gene alon led signific cell expans inhibit cell death indic caspas alox depend pathway function parallel regul cell death vivo unbias whole genom screen reveal erk alox mediat pathway promot membran lipid peroxid nuclear transloc cytolyt molecul lead execut cell death parallel caspas signal cascad | D045304;D008928 | T116;T026;T126;T123;T043 |
36,231,014 | secret flavonoid synthesi mushroom cell flavonoid chemic compound occur wide across plant kingdom consid valuabl food addit pro health properti sourc also identifi kingdom especi interest abil edibl mushroom synthes flavonoid mushroom usual defin group fungal speci capabl produc macroscop fruit bodi mani articl consid content flavonoid group fungi wherea synthesi flavonoid reveal myceli cell abil mushroom fruit bodi produc flavonoid seem clear resolv articl overview latest key scientif find flavonoid mushroom outlin organ current state knowledg abil mushroom fruit bodi synthes import group compound vital process put puzzl current state knowledg flavonoid biosynthesi mushroom cell togeth propos univers scheme studi unambigu decid whether fruit bodi individu mushroom capabl synthes flavonoid | D000363 | T004 |
36,231,013 | human dsp acm mous model display stress induc cardiac electr structur phenotyp arrhythmogen cardiomyopathi acm inherit disord character fibro fatti infiltr increas propens ventricular arrhythmia sudden death genet variant desmosom gene associ acm incomplet penetr common featur acm famili complic understand extern stressor contribut toward diseas develop analyz dual role genet extern stressor acm progress develop one first mous model acm recapitul human variant introduc murin equival human rg variant endogen desmoplakin dsprg mice homozyg variant display embryon lethal dsprg mice viabl reduc express dsp present arrhythmogen structur phenotyp identifi baselin howev increas afterload result reduc cardiac perform increas chamber dilat acceler progress heart failur addit follow catecholaminerg challeng dsprg mice display frequent prolong arrhythm event final aberr local connexin note dsprg mice baselin becom appar follow cardiac stress via pressur overload summari cardiovascular stress key trigger unmask electr structur phenotyp one first human acm mous model | D019571 | T047;T019 |
36,231,012 | determin reactiv oxygen nitrogen speci novel volatil organ compound defens respons tomato plant botryti cinerea induc trichoderma viren trs present studi trichoderma viren trs decreas grey mould diseas caus botryti cinerea tomato plant lycopersicum l enhanc defens respons general plant belong remiz varieti infect effect b cinerea perkoz plant generat reactiv molecul superoxid peroxynitrit onoo less hydrogen peroxid h nitrosothiol sno green leaf volatil glv among new find histochem analys reveal b cinerea infect caus nitric oxid accumul chloroplast detect plant treat trs treatment plant trs caus system spread h accumul apoplast nuclei spme gcxgc tof ms analysi reveal volatil organ compound voc releas tomato plant treat trs hexanol deriv eg ethyl hexyn hexadien ol salicyl acid deriv eg hepten yl isoamyl salicyl consid protect tomato plant b cinerea first time result valuabl studi aim determin locat function plant treat trichoderma check contribut detect voc plant protect b cinerea | D035901;D018551;D026403;D055549 | T002;T121;T109;T123;T168;T004 |
36,231,011 | provision matrix format implant surfac bridg role calcium ion success dental implant lie strong last integr patient receiv bone first biolog interact implant surfac determin subsequ evolut integr process studi set object analyz mechanist interact earli regen matrix implant surfac modifi calcium ion ca compar standard implant surfac noca put surfac quartz crystal microbal dissip qcm monitor frequenc shift f viscoelast properti adsorb biofilm use scan electron microscopi sem visual result interfac upon addit human blood plasma ca surfac form adsorb three dimension film attach surfac f hz noca biofilm form attach surfac f hz min blood two repres commerci implant ca noca surfac show also distinct interfac ca implant form visibl clot attach implant compos main platelet surfac coverag red blood cell sc entrap within fibrin network sc noca implant larg popul red blood cell sc scarc fibrin remnant sc implant show clot surfac macroscop pre clinic clinic result discuss work encourag modif titanium implant surfac calcium ion improv bone regen process taken togeth result add inform role ca ion bridg format provision matrix implant surfac effect implant osseointegr | D015921;D014025 | T074;T196 |
36,231,010 | thyroid hormon induc oral cancer growth via pd l depend signal pathway oral cancer fatal diseas incid taiwan increas thyroid hormon l thyroxin stimul cancer cell prolifer via receptor integrin v plasma membran also induc express program death ligand pd l cell prolifer cancer cell thyroid hormon also activ catenin depend cell prolifer cancer cell howev relationship pd l cancer prolifer fulli understood current studi investig role induc thyroid hormon induc pd l regul gene express prolifer oral cancer cell thyroxin bound integrin v induc pd l express via activ erk signal transduc activ transcript stat inactiv stat inhibit pd l express nuclear pd l accumul inhibit pd l express reduc catenin accumul furthermor nuclear pd l form complex nuclear protein p suppress pd l express shrna block express pd l catenin also signal transduct prolif gene express cancer cell growth summari thyroxin via integrin v activ erk stat stimul pd l depend catenin relat growth oral cancer cell | D060890;D009062 | T191;T116;T129 |
36,231,009 | nestin modul airway smooth muscl cell migrat affect spatial rearrang vimentin network focal adhes assembl airway smooth muscl cell migrat play role progress airway remodel hallmark allerg asthma howev mechan regul cell migrat yet entir understood nestin class vi intermedi filament protein involv proliferationregener neuron cancer cell skelet muscl role cell migrat fulli understood nestin knockdown kd inhibit migrat human airway smooth muscl cell use confoc microscopi imari softwar found nestin kd attenu focal adhes size cell spread moreov polo like kinas plk vimentin phosphoryl ser previous shown affect focal adhes assembl nestin kd reduc plk phosphoryl thr indic plk activ vimentin phosphoryl ser contact vimentin filament paxillin morpholog focal adhes moreov express vimentin phosphoryl mimic mutant sd aspart acid substitut ser rescu migrat vimentin reorgan focal adhes size nestin kd cell togeth result suggest nestin promot smooth muscl cell migrat mechanist nestin regul plk phosphoryl mediat vimenitn phosphoryl connect vimentin filament paxillin focal adhes assembl | D022001;D007382 | T026 |
36,231,008 | viscer adipos tissu ef mirna pathway associ type diabet human extrem obes object regul express transcript factor ef human viscer adipos tissu vat character dysmetabol obes sub phenotyp ef mirna network describ multipl cancer investig whether elev vat ef obes associ vat mirna alter similar distinct describ cancer furthermor assess ef associ mirna chang may contribut link high vat ef dysmetabol obes phenotyp method assembl cohort patient obes high vat ef match age sex bmi patient low vat ef without obes patientsgroupx group perform nanostr base mirna profil vat sampl patient candid ef relat mirna valid qpcr independ cohort patient extrem obes without type diabet tdm n bioinformat tool manipul ef express cell use establish plausibl function vat ef mirna network obes result among n identifi mirna differenti express relat ef obes evid cancer relat ef mirna network identifi human vat obes hek cell overexpressiondownregul ef correspond alter express mirna mirna p two mirna report metabol function consist ef vat cohort express mirna p intercorrel correl express ef cohort detect signific associ biochem paramet cohort patient extrem obes high vat ef show diabet complic obes phenotyp higher express mirna mirna p also correl fast glucos level mirna fast insulin mirna p conclus whilst previous describ cancer relat ef mirna network appear oper vat obes mirna p may link high ef express vat diabet complic extrem obes phenotyp | D003924;D035683 | T047;T123;T114 |
36,231,007 | recent progress futur prospect crisprca deriv transcript activ crispra system plant genom edit technolog becom one hottest research area recent year among divers genom edit tool cluster regular interspac short palindrom repeatscrispr associ protein system crisprca system exhibit obvious advantag specif simplic flexibl previous genom edit system addit emerg cas mutant dcas dead cas lost endonucleas activ maintain dna recognit activ guid rna provid power genet manipul tool particular combin dcas protein transcript activ achiev specif regul gene express made import contribut biotechnolog medic research well agricultur crisprdca activ crispra increas transcript endogen gene overexpress foreign gene tradit transgen technolog plant cell routin method verifi gene function elev gene transcript one main limit overexpress vector capac constraint make difficult express multipl gene use typic ti plasmid vector agrobacterium crispra system overcom limit tradit gene overexpress method achiev multipl gene activ simpli design sever guid rnas one vector review summar latest progress base develop crispra system includ suntag dcas vpr dcas tv scrna sam crispr act applic plant furthermor limit challeng current crispra system futur prospect applic also discuss | D064130;D064113 | T040;T123;T116 |
36,231,006 | post translat modif cgas sting critic switch immun regul innat immun mechan initi immun respons via pattern recognit receptor prrs cyclic gmp amp synthas cgas member prrs sens divers pathogen endogen dna activ innat immun signal pathway includ express stimul interferon gene sting type interferon inflammatori cytokin turn instruct adapt immun respons develop groundbreak discoveri rapid advanc research host defens cancer biolog autoimmun disord sinc cgasst enorm potenti elicit innat immun respons understand function regul critic widespread effici regulatori mode cgas sting pathway post translat modif ptms coval linkag function group amino acid chain general consid regulatori mechan protein destruct renew review discuss cgas sting signal transduct mechan relat diseas focus current differ regulatori modal ptms control cgas sting trigger innat immun inflammatori respons | D007370;D008565 | T116;T192;T121;T123;T129 |
36,231,005 | brain endotheli cell contrari aortic transport degrad low densiti lipoprotein via ldlr alk transport low densiti lipoprotein ldl endothelium key step develop atherosclerosi notori phenotyp differ exist endotheli cell origin differ vascular bed endotheli cell form blood brain barrier restrict paracellular transcellular passag plasma protein systemat compar brain versus aortic endotheli cell toward interact ldl role protein known regul uptak ldl endotheli cell brain endotheli cell aortic endotheli cell bind intern ldl howev wherea aortic endotheli cell degrad small amount ldl transcytos major brain endotheli cell degrad transport ldl use rna interfer sirna found ldlr clathrin pathway lead ldl degrad either endotheli cell type loss gain function experi show alk promot transcellular ldl transport aortic endotheli cell also limit ldl degrad brain endotheli cell sr bi caveolin promot ldl uptak transport aortic endotheli cell limit neither bind associ ldl brain endotheli cell togeth result indic distinct ldl traffick brain microvascular endotheli cell aortic endotheli cell | D042783;D008077 | T025;T109;T123;T116 |
36,231,004 | nrf mediat dichotomi vascular system mechanist therapeut perspect nuclear factor erythroid relat factor nrf transcript factor control express gene cluster differ categori distinct function rang redox balanc metabol protein qualiti control cell biolog consequ nrf activ either protect detriment context depend manner cardiovascular system studi focus protect properti nrf main key transcript factor antioxid defens howev emerg evid reveal unexpect role nrf mediat cardiovascular maladapt remodel dysfunct certain diseas set herein review role nrf cardiovascular diseas focus vascular diseas discuss negat effect nrf vasculatur well potenti under mechan also discuss clinic relev target nrf pathway treatment cardiovascular diseas | D000975;D051267 | T116;T121;T123;T044;T039 |
36,231,003 | glucos p dehydrogenas antioxid enzym regulatori function skelet muscl exercis hypomorph glucos p dehydrogenas gpd allel caus gpd defici affect around one twenti peopl worldwid high incid gpd defici may reflect evolutionari adapt widespread preval malaria gpd defici red blood cell rbcs hostil malaria parasit infect human although medic interest enzym defici main focus rbcs recent evid suggest broader implic gpd defici health includ skelet muscl diseas gpd catalyz rate limit step pentos phosphat pathway ppp provid precursor nucleotid synthesi dna replic well reduc nicotinamid adenin dinucleotid phosphat nadph nadph involv detoxif cellular reactiv oxygen speci ros de novo lipid synthesi associ increas ppp activ stimul cell growth report differ tissu includ skelet muscl liver kidney ppp activ increas skelet muscl embryogenesi denerv ischemia mechan overload inject myonecrot agent physic exercis fact highest relat increas activ skelet muscl enzym one bout exhaust exercis gpd suggest activ ppp occur skelet muscl provid substrat muscl repair age associ loss muscl mass strength lead decreas gpd activ protein content skelet muscl gpd overexpress drosophila melanogast mice protect metabol stress oxid damag age associ function declin result extend median lifespan review discuss whether well known posit effect exercis train skelet muscl mediat increas gpd | D005955;D008288 | T047 |
36,231,002 | liquid liquid phase separ cardiovascular diseas liquid liquid phase separ llps biochem process cell drive protein rna molecul concentr droplet droplet lipid membran rather exist distinct organell relat surround environ act biochem reaction chamber recent year signific progress made studi llps especi neurodegen diseas cancer virolog field littl known llps cardiovascular diseas cvd review discuss current understand mechan biolog function llps particular role regul cvd | D002318;D019636 | T047 |
36,231,001 | structur basi integrin insid activ integrin express leukocyt precis regul integrin critic leukocyt adhes traffick neutrophil integrin particip slow roll activ insid signal fulli activ integrin mediat rapid leukocyt arrest adhes two activ pathway start selectin ligand engag chemokin receptor ligat respect converg phosphoinositid kinas talin kindlin rap focus recent structur insight autoinhibit talin autoinhibit trimer kindlin activ talin kindlin bind cytoplasm tail separ adjac site discuss possibl pathway talin kindlin activ recruit plasma membran role integrin activ propos new model final step integrin activ involv complex talin kindlin integrin plasma membran | D018821;D016608 | T192;T123;T116;T129 |
36,231,000 | polycyst ovari syndrom endometri cancer scope review literatur gut microbiota gut dysbiosi associ polycyst ovari syndrom pcos endometri cancer ec studi investig whether gut dysbiosi may explain increas endometri cancer risk polycyst ovari syndrom aim scope review evalu extent natur publish studi gut microbiota polycyst ovari syndrom endometri cancer attempt find similar composit microbiota search public rang year due complet date human microbiom project obtain articl input keyword gut microbiom gut microbiota gut dysbiosi pcos endometri cancer search engin pubm scopus identifi initi search includ articl final review appli exclus inclus criteria although literatur grow field identifi enough publish studi investig whether gut dysbiosi may explain increas ec risk pcos within studi identifi unabl identifi consist pattern microbiom similar present studi women pcos compar women ec although found phylum firmicut similar decreas women pcos studi women ec howev signific variabl within studi identifi make high like may arisen chanc research pertain molecular microbiolog mechan relat gut microbiom need elucid greater understand contribut pathophysiolog endometri cancer patient polycyst ovarian syndrom | D016889;D000069196;D064307;D011085 | T047;T007;T028;T191;T001;T032 |
36,230,999 | use retin microvascular function telomer length age blood pressur predict individu low cardiovascular risk age repres major risk factor mani patholog limit human lifespan includ cardiovascular diseas biolog age good biomark assess earli individu risk cvd howev find good measur biolog age ongo quest studi aim assess use retin microvascular function separ combin telomer length predictor age system blood pressur individu low cardiovascular risk healthi particip low cardiovascular risk recruit divid three group group less year old group year old group year old relat telomer length rtl paramet retin microvascular function cvd circulatori marker blood pressur bp measur individu symbol regress analysi use infer chronolog age system bp measur use either rtl combin rtl paramet retin microvascular function rtl decreas signific age p also age relat differ studi group retin arteri time maximum dilat p maximum constrict p maximum constrict percentag p youngest particip error predict versus actual valu chronolog age smallest case use retin vascular function p combin paramet rtl p systol bp better predict rtl also younger individu p assess retin arteri vascular function better predictor rtl non modifi variabl age younger individu age group rtl better microvascular function infer modifi risk factor cvds older individu accumul physiolog structur biolog chang make predict unreli | D002318 | T047 |
36,230,998 | presynapt ht mglu receptor receptor crosstalk prefront cortex metamodul glutam exocytosi glutamaterg nerv end rat prefront cortex pfc possess presynapt ht heteroreceptor mglu autoreceptor whose activ inhibit glutam exocytosi measur mm kcl evok h aspart h asp releas mimic glutam exocytosi concomit activ two receptor null inhibitori activ wherea blockad ht heteroreceptor mdl strengthen inhibitori effect elicit mglu receptor agonist ly ht receptor antagonist mdl ketanserin trazodon amplifi impact low nm ly clozapin mimic ht agonist doi inhibit kcl evok h asp overflow mdl depend fashion modifi doi induc effect mglu ht protein co immunoprecipit synaptosom lysat incub pfc synaptosom mdl clozapin modifi insert mglu subunit synaptosom plasma membran conclus ht mglu receptor coloc physic associ pfc glutamaterg termin function interact antagonist like fashion control glutam exocytosi mglu ht metamodul could relev therapi central neuropsychiatr disord includ schizophrenia also unveil cellular event account develop also influenc respons drug regimen | D003024;D018094;D014196 | T121;T109;T116;T192 |
36,230,997 | timp depend modul metabol profil impact chemoresist nsclc develop chemoresist remain signific barrier treat nsclc alter cancer cell metabol import mechan chemoresist studi explor role aberr metabol timp mediat chemoresist bioinformat analysi identifi associ high timp alter energi metabol defin role depolar mitochondria reduct lactat secret higher ros level timp kd cell reduc gsh level timp modul metabol profil via acetyl mitochondri stat interact cd intrigu monom acetyl stat critic alter metabol wherea stat dimer abrog function mitochondri metabol profil also alter cisplatin resist clone cell also correl immunoexpress cd stat timp patient sampl studi provid evid timp alter metabol profil modul mitochondri metabol via cd stat axi effect stat acetyl also lent support critic role timp chemoresist interrog tcga luad dataset reveal perturb critic modul alter metabol state cancer cell higher express five gene signatur includ timp correl immunosuppress cell found associ overal surviv studi identifi sever metabol mechan could influenc therapeut option prognosi nsclc patient | D002289;D008175 | T191 |
36,230,996 | effect glucos level cardiovascular risk cardiovascular diseas remain lead caus death disabl develop cardiovascular diseas tradit associ various risk factor somehow relat unhealthi lifestyl smoke obes lack physic activ etc also risk factor associ genet predisposit well presenc concomit diseas especi chronic one one strike exampl cours type diabet metabol disord associ impair carbohydr metabol main clinic manifest type diabet elev blood glucos level link diabet cvd well known logic assum elev glucos level may import extent context heart vascular diseas review tri summar data possibl role blood glucos risk factor develop cvd | D002318;D003924 | T047 |
36,230,995 | immunogen cell death emerg target gastrointestin cancer immunogen cell death icd regul form cell death induc activ innat adapt immun respons releas damag associ molecular pattern damp subsequ recognit pattern recognit receptor prrs generat specif cd lymphocyt thus icd induc certain chemotherapeut agent target therapi radiat oncolyt virus could becom potenti cancer treatment provid antitumour immun cancer vaccin moreov combin immunotherapi especi immun checkpoint inhibitor could overcom immunosuppress tumour microenviron characteris certain cancer includ gastrointestin cancer review provid insight role icd induct colorect gastric pancreat hepatocellular carcinoma specif discuss main mechan involv icd potenti applic gastrointestin cancer treatment latest clinic trial updat | D000970;D005770;D050504 | T121;T109;T005;T191 |
36,230,994 | alter lipid metabol heart spontan hypertens rat preced left ventricular hypertrophi cardiac dysfunct disturb cardiac lipid metabol associ develop cardiac hypertrophi heart failur spontan hypertens rat shrs genet model primari hypertens patholog left ventricular lv hypertrophi high level diacylglycerol cardiomyocyt earli develop howev exact effect lipid pathway involv metabol develop cardiac dysfunct shrs unknown therefor use shrs wistar kyoto wki rat week age analyz impact perturb process involv lipid synthesi degrad develop lv hypertrophi shrs age triglycerid level higher wherea free fatti acid fa content lower lv shrs compar wki rat express de novo fa synthesi protein lower cardiomyocyt shrs compar correspond wki control higher express gene involv tg synthesi week old shrs may explain higher tg content rat adenosin monophosph activ protein kinas phosphoryl peroxisom prolifer activ receptor protein content lower cardiomyocyt week old shrs suggest lower rate oxid decreas protein content hydrolas domain contain adipos triglycerid lipas atgl activ increas content gg switch protein atgl inhibitor indic lower rate lipolysi heart shrs conclus present studi show develop lv hypertrophi myocardi dysfunct shrs associ triglycerid accumul attribut lower rate lipolysi oxid cardiomyocyt | D017379;D050356 | T047;T044 |
36,230,993 | target mast cell allerg diseas current therapi drug repurpos incid allerg diseas grown tremend past three generat current treatment effect consider unmet need mast cell critic effector allerg inflamm secret mediat receptor mediat long target allergi therapi recent drug move step earlier mast cell activ block ige il il interact receptor review summar latest therapi target mast cell well new drug clinic trial addit offer support repurpos fda approv drug target mast cell new way multitud high select drug avail cancer autoimmun metabol disord drug repurpos offer optim futur allergi therapi | D006967;D008407 | T025;T046 |
36,230,992 | di n butyl phthalat monoest metabolit impair steroid hormon biosynthesi human cell mechanist vitro studi widespread environment contamin di n butyl phthalat dbp link reduc testosteron level advers reproduct health outcom men howev under mechan anti androgen effect potenti effect class steroid hormon remain elucid conduct mechanist studi human adrenocort hr cell expos dbp metabolit mono n butyl phthalat mbp h quantif steroid hormon cell medium liquid chromatographi mass spectrometri reveal phthalat signific decreas testosteron androstenedion corticosteron progesteron level particular dibutyryl cyclic amp stimul steroidogenesi western blot analysi key steroidogen protein show dbp induc dose depend decreas cypa hsd level mbp signific decreas cypa level indic compound affect earli step steroidogenesi differ dbp mbp exposur also lead dose relat decreas hsd enzym catalyz final step testosteron biosynthesi pathway although effect statist signific interest dbp increas cortisol concentr may due non signific cypb increas dbp expos cell contrast mbp decreas cortisol concentr moreov analysi superoxid generat quantif protein oxid marker nitrotyrosin demonstr dbp induc oxid stress hr cell mbp reduc protein nitrotyrosin level find confirm anti androgen effect dbp mbp reveal sever differ toxicolog mechan possibl implic futur research phthalat toxic | D002786;D003993 | T121;T109;T126;T116 |
36,230,991 | adjust strategi venus flytrap photosynthet apparatus uv radiat object studi investig respons photosynthet apparatus venus flytrap dionaea muscipula j elli uv radiat stress well role select secondari metabolit process plant subject h uv treatment subsequ chl fluoresc gas exchang measur live plant collect materi analys photosynthet pigment photosynthet apparatus protein content well content activ select antioxid perform measur analys carri immedi stress treatment uv plant anoth h termin uv exposur recoveri plant uv plant show chang structur function photosynthet apparatus increas content activ antioxid led effici co carboxyl recoveri plant disrupt electron flow observ result lower photosynthesi effici result reveal muscipula plant underw two phase adjust uv radiat first regulatori phase relat exploit avail mechan prevent reduct psii rc addit uv plant increas accumul plumbagin potenti compon protect mechan disrupt redox homeostasi second acclimat phase initi run regulatori process decreas photosynthesi effici | D031257 | T002 |
36,230,990 | dendrit cell long evolv road toward success target cancer dendrit cell dcs uniqu myeloid cell lineag play central role prime adapt immun respons attract target immun oncolog base therapeut approach howev target cell proven challeng mani studi prove inconclus benefit clinic trial set review highlight known unknown rare power immun cell technolog expand understand complex dc develop subset respons featur left appli knowledg design new therapeut strategi cancer propos util technolog multiom approach allow improv direct target dcs clinic trial set addit dc research communiti consid consensus subset nomenclatur distinguish new subset function phenotyp chang respons environ | D003713;D009369 | T191;T025 |
36,230,989 | mechanist understand olfactori neuroepithelium involv lead short term anosmia covid use advers outcom pathway framework loss sens smell anosmia includ covid symptom world health organ major patient recov sens smell within week postinfect short term anosmia other report persist anosmia sever studi investig mechan lead anosmia covid howev evid scatter mechan remain poor understood base comprehens review literatur aim evalu current knowledg uncertainti regard mechan lead short term anosmia follow sar cov infect appli advers outcom pathway aop framework well establish toxicolog propos sequenc measur key event kes lead short term anosmia covid kes sar cov spike protein bind ace express sustentacular sus cell olfactori epithelium oe viral entri sus cell viral replic sus cell sus cell death damag olfactori sensori neuron olfactori epithelium oe aop align approach allow identif gap research conduct therapeut intervent could act final aop give frame explain sever diseas featur link specif factor lead interindividu differ respons sar cov infect | D000073931;D000086382;D000857 | T047;T067;T033 |
36,230,988 | transcutan auricular vagus nerv stimul enhanc cerebrospin fluid circul restor cognit function rodent model vascular cognit impair vascular cognit impair vci common sequela cerebrovascular disord although transcutan auricular vagus nerv stimul tavn consid complementari treatment various cognit disord preclin data effect tavn vci mechan remain ambigu measur cerebrospin fluid csf circul tavn use vivo two photon microscopi csf vasculatur tracer vci induc transient bilater common carotid arteri occlus tbccao surgeri mice anim underw anesthesia site stimul tavn min cognit test includ novel object recognit maze test perform h last treatment long term treatment group receiv day treatment test day short term treatment group receiv day treatment test day tbccao surgeri csf circul increas remark tavn group anesthesia control site stimul control group cognit impair induc tbccao signific restor long short term tavn term effect long short term stimul show similar recoveri effect find provid evid tavn facilit csf circul repetit tavn amelior vci symptom | D060825;D004561;D055536 | T061;T048 |
36,230,987 | tgf promot zika virus infect immort human first trimest trophoblast via smad pathway zika virus zikv well known caus congenit zika syndrom infect occur pregnanc howev mechan virus infect cross placenta barrier complet understood pregnanc tgf abund matern fetal interfac tgf report enhanc rubella virus bind infect human lung epitheli cell therefor studi investig role tgf zikv infect immort human first trimest trophoblast ie swan cell treat tgf ngml two day inocul virus american strain prvabc multipl infect five result show enhanc zikv infect demonstr immunofluoresc assay flow cytometri analysi enhanc infect effect abolish use sb sb inhibitor tgf smad signal pathway approxim fold increas virus bind studi trophoblast found presenc smad inhibitor virus replic signific suppress enhanc tyro axl receptor zikv express induc tgf also note result suggest tgf promot virus infect via smad pathway studi carri clarifi under mechan find | D000071244;D000071243 | T047;T005 |
36,230,986 | liquid liquid phase separ biomacromolecul role metabol diseas liquid liquid phase separ llps compartment concentr biomacromolecul liquid like condens under membraneless organell mlos format eukaryot cell increas evid llps concept method phenomenon novel principl account explain precis spatial tempor regul cellular function moreov phenomenon llps tend concentr protein often accompani sever abnorm signal human diseas report multipl metabol diseas strong associ deposit insolubl proteinac aggreg term amyloid present recent studi observ role llps sever metabol diseas includ type diabet mellitus tdm alzheim diseas ad metabol bone diseas mbds review aim expound current concept method llps summar vital role tdm ad mbds uncov novel mechan metabol diseas thus provid power potenti therapeut strategi target amelior metabol diseas | D003924 | T047 |
36,230,985 | modulatori role tppp microtubul organ impact alpha synuclein patholog parkinson diseas character locomot deficit dopaminerg neuron loss alpha synuclein syn aggreg tubulin polymer promot protein tpppp tppp also implic process moonlight chameleon tppp modul dynamicsst multifunct microtubul network promot acetyl bundl previous identifi microtubul associ tppp homologu tppp lack n terminus howev involv physiolog patholog process elucid work shown modulatori role tppp similar tppp microtubul organ well homo hetero associ tppp tppp contrast tppp virtual bind syn consequ promot syn aggreg anti aggreg potenc achiev counteract format tppp syn patholog complexaggreg lead parkinson interact tppp determin quantifi vitro recombin human protein cell extract live human cell use differ method includ bifunct fluoresc complement tight associ tppp tppp syn may ensur uniqu mechan inhibitori effect tppp select fragment may becom lead agent develop anti parkinson agent | D010300;D051844 | T047;T123;T116 |
36,230,984 | stat pathway dysregul underestim role urolog tumor nowaday molecular research essenti better understand tumor cell pathophysiolog increas number neoplasm taken molecular magnifi glass therefor possibl discov complex relationship cytophysiolog tumor cell signal transduc activ transcript stat belong famili latent cytoplasm transcript factor call stat compris seven member stat stat stat stat stata statb stat protein play import role cytokin activ gene express transduc signal cell membran nucleus abnorm prolong activ result tumorigenesi metastasi cell prolifer invas migrat angiogenesi inhibit transcript factor inhibit previous mention effect cancer cell wherea normal cell affect henc stat might viabl target cancer therapi | D050796;D014571 | T191;T123;T116 |
36,230,983 | identif metabolom biomark extracrani carotid arteri stenosi biochem identif carotid arteri stenosi cas still challeng henc male subject normal control stroke patient extracrani cas diamet stenosi recruit blood sampl collect day stroke onset acut ill carotid plaqu score use defin cas sever serum metabolit analyz use target absolut idq p kit result show hypertens diabet smoke alcohol consumpt common level diastol blood pressur hdl c ldl c cholesterol lower cas patient control p lt suggest intens medic treatment cas pca pls da demonstr clear separ control cas patient decis tree random forest show acylcarnitin speci c c c amino acid biogen amin sdma glycerophospholipid pc aa c pc ae c contribut predict cas metabolit panel analysi show high specif low sensit detect cas respect present studi suggest metabolom profil could help differenti control cas patient monitor progress cas | D016893;D020521 | T047;T020 |
36,230,982 | distinct activ toll like receptor human sampl sepsi clinic success toll like receptor tlr antagonist sepsi therapi thus far lack inhibit receptor use receptor activ stratif patient activ tlr would desir aim establish assay quantifi phosphoryl tlr use proxim ligat assay pla hek tlrmdcd well thp cell stimul lps activ tlr measur use pla furthermor peripher blood mononuclear cell pbmcs sepsi patient use show feasibl assay clinic materi activ tlr sampl compar pbmcs healthi individu could show transient activ tlr cell line five min lps stimul signal increas fold hek cell fold thp cell assay also work well pbmcs septic patient phosphoryl tlr studi inclus time higher septic patient compar healthi volunt conclud establish diagnost assay abl quantifi phosphoryl tlr cell cultur clinic sampl sepsi patient make larg scale stratif sepsi patient tlr activ status possibl | D018805 | T047;T046 |
36,230,981 | obligatori role ampk activ antioxid defens pathway regulatori effect metformin cellular protect prevent len opac increas level oxid stress due deterior nrf nfe relat factor antioxid respons element pathway found primari caus age pathobiolog metformin anti age effect delayhalt age relat diseas herein use len epitheli cell line lec human h mous age hm primari lec along lens model system demonstr metformin could correct deterior bmalnrfar pathway reviv ampk activ transcript activ bmalnrf result increas antioxid enzymat activ express phase ii enzym ensu reactiv oxygen speci ros mitig cytoprotect prevent len opac respons agingoxid stress intrigu observ metformin intern lenslec upregul oct organ cation transport mechanist found metformin evok ampk activ depend increas bmal nrf antioxid transcript promot direct e box bind bmal nrf promot loss function disrupt e boxar identifi metformin act increas bmalnrf mediat antioxid express data show ampk activ requisit bmalnrf antioxid mediat defens pharmacolog inactiv ampk imped metformin effect collect result first time shed light hitherto incomplet uncov crosstalk ampk bmalnrfantioxid mediat metformin blunt oxidativeag link pathobiolog | D002386;D008687 | T047;T121;T109;T190;T033 |
36,230,980 | hedgehog signal therapeut target airway remodel inflamm allerg asthma genom wide associ studi gwas shown variant patch homolog ptch associ lung function abnorm general popul also shown sonic hedgehog shh import ligand ptch upregul airway epithelium patient asthma suggest involv airway remodel contribut hedgehog signal airway remodel inflamm asthma poor describ determin biolog role hedgehog signal associ gene asthma gene silenc express pharmacolog inhibit studi conduct stimul human airway epitheli cell transform growth factor tgf import fibrot mediat asthmat airway remodel also interact shh pathway tgf increas hedgehog signal relat gene express includ shh gli gli knockdown ptch smo sirna use hedgehog signal inhibitor consist attenu cola express induc tgf stimul contrast ptch express augment tgf induc increas cola mmp gene express also show increas hedgehog signal relat gene express primari airway epitheli cell control asthmat differ stage cellular differenti gant inhibitor gli attenu tgf induc increas cola protein express primari airway epitheli cell differenti air liquid interfac final model airway tissu remodel vivo cbl wildtyp wt ptch mice intranas challeng hous dust mite hdm phosphat buffer salin pbs control ptch mice show reduc sub epitheli collagen express serum inflammatori protein compar wt mice respons hdm challeng conclus tgf induc airway remodel partial mediat hedgehog signal pathway via ptch smo gli axi hedgehog signal pathway promis new potenti therapeut target allevi airway tissu remodel patient allerg airway diseas | D056151;D001249 | T047;T046;T033 |
36,230,979 | nucleolus nucleolar stress cell fate decis diseas develop besid canon function ribosom biogenesi signific recent advanc toward fascin role nucleolus stress respons cell destini decis diseas progress nucleolar stress emerg concept describ aberr nucleolar structur function result impair rrna synthesi ribosom biogenesi stress condit link varieti signal transduct includ limit mdm p nf b hif pathway studi uncov nucleolus stress sensor signal hub cell encount various stress condit nutrient depriv dna damag oxid thermal stress consequ nucleolar stress play pivot role determin cell fate apoptosi senesc autophagi differenti respons stress induc damag nucleolar homeostasi involv pathogenesi various chronic diseas particular tumorigenesi neurodegen diseas metabol disord mechanist insight reveal indispens role nucleolus initi signal progress diseas accord intervent nucleolar stress may pave path develop novel therapi diseas review system summar recent find link nucleolus stress respons signal transduct cell fate decis set spotlight mechan nucleolar stress drive diseas progress highlight merit interven nucleolus diseas treatment | D016328;D016159 | T123;T116;T129 |
36,230,978 | delay egf stimul egfr degrad myoton dystrophi type dm myoton dystrophi type dm autosom domin diseas caus ctg repeat expans untransl region dystrophia myotonica protein kinas gene akt dephosphoryl autophagi associ dm autophagi wide studi dm although endocyt pathway akt critic role endocytosi phosphoryl mediat activ tyrosin kinas receptor epiderm growth factor receptor egfr egf activ egfr trigger intern degrad ligand receptor complex serv pikakt signal platform use primari fibroblast healthi subject dm patient dm deriv fibroblast show increas autophagi flux enlarg endosom lysosom thereaft cell stimul high concentr egf promot egfr intern degrad interest egf bind egfr reduc dm cell egfr intern also slow earli step endocytosi howev egf activ egfr enhanc akt erk phosphoryl level dm deriv fibroblast therefor delay egf stimul egfr endocytosi dm cell alter might due decreas bind egf egfr decreas akt phosphoryl | D004815;D009223 | T121;T047;T116;T125 |
36,230,977 | effect hypoxia transcriptom profil lung fibroblast idiopath pulmonari fibrosi idiopath pulmonari fibrosi ipf age associ diseas character exacerb extracellular matrix deposit disrupt oxygen exchang hypoxia transcript factor hif influenc numer circuit could perpetu fibrosi increas myofibroblast differenti promot extracellular matrix accumul therefor work aim elucid signatur hypoxia transcriptom circuitri ipf deriv fibroblast determin transcriptom signatur gene express analysi six line lung fibroblast normoxia hypoxia perform three cell line deriv patient ipf three healthi donor total replic use clariom platform allow us evalu huge number transcript analyz respons hypoxia control ipf control respons greater number gene complex search specif gene respons ipf fibroblast phenotyp nineteen dysregul gene found lung fibroblast ipf patient hypoxia nine upregul ten downregul sens signal pathway reveal affect pulmonari fibroblast patient ipf may repres adapt chronic hypoxia | D054990 | T047 |
36,230,976 | neuroprotect effect mglu receptor antagonist mediat enhanc gabaerg synapt transmiss via presynapt cb receptor mechan studi investig cross talk mglu cb receptor modul gaba hippocamp output whole cell voltag clamp record rat hippocamp acut slice organotyp hippocamp slice expos oxygen glucos depriv ogd gerbil subject global ischemia cb receptor express studi use immunohistochemistri ca content anandamid aea arachidonoylglycerol ag measur lc msms result show mglu receptor antagonist enhanc sipsc ca pyramid cell basal ischem hippocamp releas gaba vivo manner mediat cb receptor activ hippocamp slice expos ogd ischem gerbil mglu receptor antagonist protect ca pyramid cell post ischem injuri effect reduc cb receptor activ ogd induc transient increas hippocamp content aea effect prevent mglu receptor antagonist final ogd induc late disrupt cb receptor ca region effect prevent ca pyramid cell protect mglu antagonist altogeth result suggest cooper interact mglu receptor endocannabinoid system mechan lead post ischem neuron death | D063388;D018696 | T121;T169;T109;T123 |
36,230,975 | develop cerebellar reserv cerebellar reserv defin capac cerebellum compens restor follow injuri uniqu cerebellar abil attribut various form synapt plastic incorpor multimod redund cerebellar input two major featur cerebellar circuitri assum cerebellar reserv acquir age year matur cerebellar adapt behavior cerebellar function connect howev acquir cerebellar reserv also affect two factor vulner growth potenti develop cerebellum first cerebellar injuri critic period neural circuit format especi fetal neonat life infanc lead persist dysfunct cerebellum target result limit cerebellar reserv second growth potenti appear facilit cerebellar reserv stage cerebellar reserv still immatur base find present mini review propos possibl development trajectori under acquisit cerebellar reserv highlight import studi dedic understand cerebellar resili injuri | D002531;D009473 | T043;T023;T042 |
36,230,974 | metformin prevent delay develop progress osteoarthr new insight mechan action year metformin wide prescrib physician treat type diabet along depth research metformin molecular mechan recent decad metformin also propos effect drug prevent delay musculoskelet disord includ osteoarthr oa occurr develop oa deem associ impair mitochondri function articular chondrocyt metformin activ pathway express ampk sirt protect mitochondri function chondrocyt therebi promot osteoblast product moreov clinic signific metformin combin therapi prevent oa also demonstr review aim comprehens summar current research progress metformin propos drug oa prevent treatment | D003924;D008687;D010003 | T121;T047;T109 |
36,230,973 | platelet cybernet regul ischem inflammatori respons pnc format regul extracellular nucleotid metabol signal ischem event associ sever inflamm refer ischem inflammatori respons iir recent studi identifi format platelet neutrophil complex pnc key player iir investig role extracellular platelet nucleotid signal context iir defin cybernet circl includ descript feedback loop cybernet circl seek integr differ level inform understand biolog system function studi specifi compon cybernet system platelet iir describ theoret progress iir pass cybernet cycl posit negat feedback loop base nucleotid depend signal function regul cybernet compon feedback loop explor cytometri immunohistolog stain function block antibodi adpatp measur use sever ex vivo vivo approach confirm cybernet paramet control sensor effector vasp phosphoryl py adora gpiibiiia activ well set point adp adenosin interf control disturb variabl ischemia demonstr impact regul platelet neutrophil complex pnc format blood result damag affect inflam tissu taken togeth extracellular nucleotid signal pnc format tissu damag iir integr control cybernet circl platelet function introduc studi | D001792;D009504 | T025 |
36,230,972 | activ cgas sting signal inhibit prolifer bladder cancer immun effect cisplatin cisplatin common use neoadjuv adjuv system therapi advanc bladder cancer immun relat mechan still unclear explor immun effect cisplatin bladder cancer would complement comprehens mechan cisplatin provid basi combin therapi cisplatin immunotherapi bladder cancer confirm immun effect cisplatin tccsup bladder cancer cell line vitro explor import function immun effect bladder cancer microenviron mice tumor model found cisplatin induc immun respons bladder cancer rna sequenc valid cgas sting signal deepli involv respons cisplatin induc cgas sting signal inhibit prolifer bladder cancer increas infiltr percentag cd cell dendrit cell transplant mice tumor model accumul dsdna releas chromatin bound cgas import activ downstream sting find indic cisplatin relat immun effect bladder cancer cisplatin combin immunotherapi might synergist effect bladder cancer therapi | D002945;D001749 | T121;T197;T191 |
36,230,971 | strong sar cov cell respons one two covid vaccin booster allogen hematopoiet stem cell recipi full explor immun respons deserv anti sar cov vaccin booster especi context allogen hematopoiet stem cell transplant allo hsct although sever report indic success humor respons patient literatur scarc cellular specif immun b antibodi cell respons explor one v n two v n bntb mrna vaccin booster allo hsct recipi median day post transplant lt year n result compar control receiv one booster bntb n mrna n control develop protect antibodi level gt bauml anti spike cell respons similar patient develop protect antibodi level without differ v v vs p display cell respons median frequenc anti spike cell differ either control whole cohort patient although signific lower v v patient covid infect sole observ individu receiv one booster result indic four vaccin inject help achiev satisfactori level humor cellular immun protect allo hsct patient | D000086382;D018380;D014612 | T047;T116;T061;T121;T129;T067 |
36,230,970 | modif long non code rna hnfa facilit cell cycl progress colorect cancer via igfbp mediat ccnd mrna stabil long non code rnas modul tumor occurr differ molecular mechan report hnfa hnfa antisens rna differ express multipl tumor role hnfa colorect cancer less analyz mechan regul cell cycl complet elucid | D015179;D035683;D062085 | T191;T123;T114 |
36,230,969 | hypoxia induc express annexin enhanc resist tripl negat breast cancer cell egfr ar antagonist physiolog chang hypoxia tumor microenviron tme endow cancer cell malign properti lead tumor recurr rapid progress assess effect hypoxia oxygen tumor suppressor annexin anxa respons tripl negat breast cancer tnbc cell epiderm growth factor receptor egfr androgen receptor ar target therapi demonstr brief exposur tnbc cell hypoxia within h associ regul anxa gt h exposur cell type depend stimul express anxa hypoxia depict express stabil hif led regul hif target gene slca pgk well ar ar target gene fabp ppar cellular level anxa protein decreas prolong hypoxia regul anxa tnbc cell inhibit anxa express enhanc express cellular level hif slca pgk rnai mediat inhibit hypoxia induc anxa express also strong inhibit glucos uptak ros product anxa express tnbc cell use luciferas report assay confirm short term exposur cell hypoxia inhibit prolong exposur cell hypoxia enhanc anxa promot activ hekt cell compar cell cultur normoxia tnbc cell resist lapatinib hypox condit downregul anxa sensit cell egfr well ar antagonist data suggest anxa hypoxia induc gene target anxa upregul may benefici overcom tnbc resist egfr andor ar target therapi | D017317;D064726 | T191;T123;T116 |
36,230,968 | effect cannabidiol aqueous humor outflow trabecular meshwork cell signal intraocular pressur iop regul primarili aqueous humor product ciliari bodi drainag uveoscler trabecular meshwork tm tissu goal studi measur effect non psychotrop cannabidiol cbd aqueous humor outflow tm assess effect cbd tm cell signal pathway import regul outflow perfus porcin eye anterior segment explant use investig effect cbd aqueous humor outflow cultur porcin tm cell use studi effect cbd tm cell contractil myosin light chain mlc myosin phosphatas target subunit mypt phosphoryl rhoa activ anterior segment perfus experi aqueous humor outflow increas signific within h ad cbd effect sustain h measur treatment tm cell cbd signific decreas tm cell mediat collagen contract inhibit phosphoryl mlc mypt reduc rhoa activ data demonstr first time potenti therapeut agent lower intraocular pressur cbd enhanc aqueous humor outflow modifi tm cell signal | D002185;D014129 | T121;T023;T109 |
36,230,967 | metabolom diabet retinopathi potenti biomark molecular basi oxid stress diabet retinopathi dr lead caus blind work age adult one common complic diabet mellitus dm featur metabol disord global preval diabet incid dr expect increas prompt detect target anti oxid stress intervent could effect reduc visual impair caus dr howev diagnosi treatment dr often delay due absenc obvious sign retina imag research progress support metabolom power tool discov potenti diagnost biomark therapeut target caus oxid stress profil metabolit diseas provid great opportun dr metabol heterogen thus review summar latest advanc metabolom dr well potenti diagnost biomark predict molecular target integr genom wide associ studi gwas metabolom metabolom provid potenti biomark molecular target therapeut strategi control progress dr especi intervent earli stage precis treatment base individu patient variat | D003920;D003930 | T047 |
36,230,966 | wheat head blight pathogen fusarium graminearum recruit collabor bacteria soil natur fungal endophyt often facult endohyph bacteria feb model plant pathogen fungus affect phenotyp construct growth systemmicrocosm allow f graminearum isol grow natur soil isol gentamicin contain medium allow endohyph growth bacteria kill bacteria f graminearum ph label hismcherri gene stain fungal nuclei fluoresc red use confirm isol fungus new isol contain srrna gene per fungal mcherri gene determin qpcr f graminearum feb holobiont isol contain bacteria sub cultur sever time bacteri content stabl sequenc bacteri srrna gene sever fg feb holobiont isol reveal endophyt bacteria known capabl nitrogen fixat test pathogen one common fg feb holobiont associ f graminearum stenatrophomona maltophilia found increas pathogen srrna gene load per fungal hismcherri gene insid wheat stay previous found vitro final strong evid found fg maltophilia symbiot nitrogen fixat benefit fungus | D012987;D014908 | T167;T168;T002 |
36,230,965 | recent develop role calcium signal potenti therapi target cervic cancer intracellular calcium ca concentr ca implic prolifer invas metastasi cancer tissu varieti oncolog therapi candid drug induc antitumor effect part whole modul ca cervic cancer one common cancer among women worldwid recent major research advanc relat ca signal cervic cancer emerg review comprehens describ current progress concern role ca signal occurr develop prognosi cervic cancer enhanc understand causat mechan ca signal cervic cancer thus provid new sight identifi potenti therapeut target drug discoveri | D002118;D002583 | T121;T191;T123;T196 |
36,230,964 | current understand neural stem cell nich neural stem cell nscs self renew multipot cell give rise compon central nervous system cns embryogenesi also activ respons injuri diseas maintain certain level neurogen activ throughout adulthood activ take place special region brain neurovascular nich whose main role control behaviour cns adult mammal two main canon nich describ subventricular zone svz later ventricl subgranular zone sgz dentat gyrus review discuss current understand neural stem cell canon nich well structur behaviour role neural diseas | D058953 | T025 |
36,230,963 | macrophag chronic inflamm insulin resist preval obes reach alarm level consid major risk factor sever metabol diseas includ type diabet td non alcohol fatti liver atherosclerosi ischem cardiovascular diseas obes induc chronic low grade inflamm may lead insulin resist well recogn macrophag play major role inflamm current review molecular mechan under macrophag low grade tissu inflamm insulin resist td describ also role macrophag obes induc insulin resist present therapeut drug recent advanc target macrophag treatment td introduc | D003924;D007333 | T047;T046 |
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