PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,230,962 | distinct impair character differ adnp mutant reveal aberr cytoplasm nuclear crosstalk background activ depend neuroprotect protein adnp essenti neuron structur function multipl de novo patholog mutat adnp caus autist adnp syndrom suggest affect alzheim diseas progress somat form ask differ adnp mutat produc specif neuron like phenotyp toward better understand person medicin method employ crisprca genom edit ne neuroblastoma cell form neuron like cell line express adnp mutant protein conjug gfp new cell line character quantit morpholog immunocytochemistri live cell imag result novel cell line constitut express gfp adnp ppro pser human orthologu gfp adnp ptyr ptyr human orthologu reveal new distinct phenotyp increas neurit number day cultur increas neurit length upon differenti day cultur link ppro contrast ptyr decreas cell number day discret phenotyp associ increas express mutant protein cytoplasm reduc nuclearcytoplasm boundari observ ptyr adnp mutant line malform correct adnp deriv fragment drug candid nap conclus distinct impair character differ adnp mutant reveal aberr cytoplasm nuclear crosstalk | D001321;D009419 | T123;T116;T048 |
36,230,961 | identif immun relat prognost signatur glioblastoma comprehens bioinformat experiment analys glioblastoma gbm poor prognosi account cancer brain central nervous system pauciti research prognost indic associ tumor immun microenviron gbm patient accur tool risk assess gbm patient urgent need | D005909 | T191 |
36,230,960 | shine light autophagi skin pigment pigmentari disord autophagi vital process cell surviv preserv homeostasi recycl disassembl unnecessari dysfunct cellular constitu autophagi amelior skin integr regul epiderm differenti constitut pigment induc melanogenesi contribut skin color melanosom turnov autophagi activ involv skin phenotyp plastic cell function mainten alter concur onset andor progress hypopigmentari hyperpigmentari disord overexpress autophagi exert protect role intrins metabol stress occur vitiligo skin dysfunct link tuber sclerosi complex hypopigment autophagi impair reduc melanosom degrad concur pigment accumul character senil lentigo melasma provid updat review describ recent find crucial role autophagi skin pigment thus reveal complex interplay among melanocyt biolog skin environ autophagi henc target process may also repres promis strategi treat pigmentari disord | D017496;D010859 | T047;T019 |
36,230,959 | mgrb mutat alter cell permeabl colistin resist klebsiella pneumonia resurg clinic use polymyxin antibiot colistin due limit treatment option infect caus carbapenem resist enterobacteral cre howev last resort antibiot current confront challeng includ emerg chromosom plasmid born colistin resist colistin resist klebsiella pneumonia common caus mutat chromosom gene mgrb mgrb span inner membran negat regul phop phosphoryl essenti bacteri outer membran lipid biosynthesi present review intend draw attent role mgrb chromosom mutat membran permeabl k pneumonia confer colistin resist grow concern regard global emerg colistin resist deciph physic chang resist membran mediat mgrb inactiv may provid new insight discoveri novel antimicrobi high effect membran penetr addit find help allevi resist situat | D003091;D007710 | T047;T116;T195 |
36,230,958 | kinet mechan exonucleolyt activ ap endonucleas nfo e coli escherichia coli apurinicapyrimidin ap endonucleas nfo one key particip dna repair princip biolog role enzym recognit hydrolysi ap site aris dna either result spontan hydrolysi n glycosid bond intact nitrogen base action dna glycosylas elimin various damag base base excis repair nfo also remov termin block group result ap lyas activ dna glycosylas addit nfo hydrolyz phosphodiest linkag side damag nucleotid nucleotid incis repair pathway function exonucleas activ nfo remain unclear probabl consist particip togeth nucleotid incis repair activ repair cluster lesion work use polyacrylamid gel electrophoresi stop flow method analyz kinet interact nfo various model dna substrat contain singl strand region data help describ mechan nucleotid cleavag determin rate correspond stage reveal rate limit stage enzymat process dissoci reaction product enzym activ site stabil termin pair nucleotid substrat affect enzymat reaction rate final found deoxynucleosid monophosph effect inhibit exonucleas activ nfo | D045647;D043603 | T126;T116 |
36,230,957 | popul tau conform drive prion like strain effect alzheim diseas relat dementia recent find divers popul prion like conform misfold tau protein expand prion concept alzheim diseas ad monogen frontotempor lobar degener ftld mapt pl suggest distinct strain misfold protein drive phenotyp progress rate mani neurodegen diseas notabl progress previous decad generat mani line proof argu yeast fungal mammalian prion determin herit well infecti trait extraordinari phenotyp divers human prion diseas aris structur distinct prion strain target differ progress speed variabl brain structur cell although human prion research present benefici lesson method studi mechan strain divers protein pathogen fundament molecular mechan tau conform form replic divers tauopathi still poor understood review summar date advanc identif divers tau conform biophys cellular experiment paradigm impact heterogen patholog tau strain person structur strain specif therapeut approach major tauopathi | D000544;D017096;D011328;D024801 | T047;T116;T048;T005 |
36,230,956 | tmem protect sepsi induc cardiac injuri via inhibit ferroptosi mice previous studi found transmembran protein tmem high associ arrhythmogen right ventricular dysplasiacardiomyopathi howev transmembran protein tmem may involv ferroptosi cardiovascular diseas studi aim explor role tmem lipopolysaccharid lps induc cardiac injuri under mechan mice inject lps mgkg h generat experiment sepsi mice also subject aav shtmem knock tmem aav tmem overexpress tmem heart hc rat cardiomyocyt also transfect ad tmem tmem sirna overexpressknock tmem result tmem knockdown heart deterior lps induc mous cardiac injuri dysfunct lps increas cardiac ferroptosi assess malonaldehyd mda cardiac iron densiti aggrav tmem knockdown moreov tmem overexpress allevi lps induc cardiac injuri dysfunct ferroptosi vitro experi show tmem overexpress inhibit lps induc lipid peroxid cardiomyocyt injuri tmem knockdown aggrav lps induc ferroptosi injuri cardiomyocyt mechanist lps increas express p ferritin decreas level gpx slca tmem could inhibit level p ferritin enhanc level gpx slca furthermor ferrostatin fer specif inhibitor ferroptosi could protect lps induc cardiac injuri also counteract deterior effect tmem silenc heart base find conclud tmem protect sepsi induc cardiac injuri via inhibit ferroptosi mice target ferroptosi cardiomyocyt tmem may therapeut strategi prevent sepsi futur | D000079403;D006335;D018805 | T043;T046;T047;T037 |
36,230,955 | autophagi cancer immunotherapi autophagi stress induc process elimin damag organell dysfunct cargo cytoplasm includ unfold protein autophagi involv construct immunosuppress microenviron tumor initi progress appear one common process involv cancer immunotherapi play bidirect role immunotherapi accumul evid suggest induc inhibit autophagi contribut immunotherapi efficaci henc explor autophagi target modifi control autophagi tumor microenviron emerg strategi facilit cancer immunotherapi review summar recent studi role autophagi cancer immunotherapi well molecular target autophagi could wake immun respons tumor microenviron aim shed light immens potenti therapeut target improv immunotherapi | D009369 | T191 |
36,230,954 | effect germanium load hydroxyapatit biomateri bone marrow mesenchym stem cell growth hydroxyapatit ha hard miner compon miner tissu main compos calcium phosphat due bioavail ha potenti use repair regener miner tissu purpos properti ha signific improv ad natur synthet materi sens germanium ge miner load ha biomateri cold isostat pressur first time character biocompat use bone marrow mesenchym stem cell bm mscs investig addit ge improv solubl stiff mpa water hold biodegrad properti ha compar control compar composit biomateri drug releas behavior ha ge higher ph maximum drug releas obtain ph ha ge biomateri among differ medium test dmem medium show higher drug releas rate especi min ha ge biomateri show better protein adhes apatit layer format ultim prove compat bm mscs cultur except higher concentr ha mgml differ concentr ge ha well coat ha ge higher bm mscs growth control find conclud fabric ha biomateri load ge could potenti biomateri cultur mammalian cell toward miner tissu repair regener | D005857;D059630 | T025;T196 |
36,230,953 | role mir cluster autophagi atherosclerosi support link lysosom storag diseas establish role non code rna ncrna especi microrna mirna regul cell function constitut current research challeng two six mirna act cluster particular mir famili compos mir mir mir mir mir b mir well character cluster function embryon develop cell differenti growth develop morphogenesi establish oncogen cluster howev role regul cellular metabol main lipid metabol autophagi receiv less attent argu mir cluster high relev two process thus could involv studi patholog deriv lysosom defici lysosom relat process control cholesterol flux regul autophagi accord compil analyz discuss current evid highlight cluster fundament role regul cellular energet metabol main lipid cholesterol flux atherosclerosi well critic particip autophagi regul process close relat lysosom also provid experiment data literatur support propos mir cluster could involv pathogenesi effect lysosom storag diseas lsd | D050197;D016464;D035683 | T047;T046;T123;T114 |
36,230,952 | atpas thoras defici caus synucleinopathi parkinson diseas like behavior parkinson diseas pd one common neurodegen diseas patholog character synucleinopathi harm dopaminerg neuron howev under mechan pathogenesi pd remain unclear aaa atpas thoras identifi essenti neuroprotect synapt plastic regul ampa receptor traffick found condit knockout thoras result motor behavior indic neurodegener genet delet thoras exacerb phenotyp synucleinopathi famili pd like mous model wherea overexpress thoras prevent syn accumul vivo biochem cell cultur studi present suggest thoras interact syn regul degrad ubiquitin syn thoras defici promot syn aggreg primari cultur neuron discoveri studi provid us understand pathogenesi synucleinopathi includ pd | D010300;D000080874 | T047 |
36,230,951 | combin treatment retino acid plus focal adhes kinas inhibitor prevent tumor growth breast cancer cell metastasi tran retino acid ra primari metabolit vitamin control develop homeostasi organ tissu ra natur synthet deriv known retinoid promis agent treat chemoprev differ neoplasia includ breast cancer bc focal adhes kinas fak crucial regul cell migrat overexpress associ tumor metastat behavior thus pharmaceut fak inhibitor faki develop counter action work hypothes ra plus faki ra faki approach could improv inhibit tumor progress silico analysi subsequ valid qpcr confirm rara src ptk encod rar src fak respect overexpress breast cell test also show differ pattern gene updown regul ra resist ra sensit bc cell addit demonstr ra resist bc cell mda mb mda mb display behavior ra treatment modul express gene involv src fak signal furthermor demonstr although ra faki administ separ decreas viabil adhes migrat mammari adenocarcinoma lm cell combin exert higher effect addit show drug individu well combin induc express apoptosi marker activ caspas cleav parp also provid evid ra effect extrapol cancer cell includ bc human cervic carcinoma hela cell orthotop assay lm tumor growth wherea ra faki administ separ reduc tumor growth combin treatment induc potent inhibit increas mice surviv moreov experiment metastat assay ra signific reduc metastat lung dissemin lm cell overal result indic ra resist could reflect deregul ra target gene includ gene encod compon src fak pathway studi demonstr ra play essenti role disrupt bc tumor growth metastat dissemin vitro vivo control fak express local ra plus faki exacerb effect thus suggest sensit ra therapi could increas faki coadministr bc tumor | D001943;D014212 | T191;T109;T131;T121 |
36,230,950 | evalu malondialdehyd level oxid stress host bacteria interact escherichia coli salmonella derbi either extract cell free suspens bacteri suspens use studi bacteri lipid peroxid process along gas chromatographi mass spectrometri liquid chromatographi mass spectrometri sever strategi thiobarbitur acid test use determin malondialdehyd mda basi commerci test kit colorimetr detect lipid peroxid aim current studi evalu lipid peroxid process level suspens extract cultur supernat escherichia coli salmonella derbi strain depend format thiobarbitur acid reactiv substanc level cell extract suspens cell free supernat bacteri speci concentr growth phase reveal effect bacteri concentr mda format also found pronounc bacteri suspens extract probabl due dynam mda releas intercellular space studi highlight possibl import mda determin cell free suspens extract well bacteri suspens elucid role lipid peroxid process bacteri physiolog bacteria host interact well host physiolog | D004926;D018384 | T007;T049 |
36,230,949 | deoxi glucos allevi cancer cachexia induc muscl wast enhanc keton metabol inhibit cori cycl cachexia character progress weight loss accompani loss specif skelet muscl adipos tissu increas lactat product either due warburg effect tumor acceler glycolysi effect cachect muscl danger factor cancer cachexia studi aim explor effici deoxi glucos dg block cori cycl activ therapeut effect cachexia associ muscl wast c adenocarcinoma xenograft model use studi cancer cachect metabol derang tumor free lean mass hindlimb muscl morpholog fiber type composit measur vivo dg administr activ ubiquitin depend proteasom pathway up autophag lysosom pathway alp assess cachect skelet muscl tumor bear mice exhibit alter glucos lipid metabol decreas carbohydr util increas lipid oxid signific increas gluconeogenesi decreas ketogenesi observ cachect mous liver dg signific amelior cancer cachexia associ muscl wast decreas cachect associ lean mass level fiber cross section area dg inhibit protein degrad associ up alp increas ketogenesi liver promot keton metabol skelet muscl thus enhanc mitochondri bioenerget capac dg effect prevent muscl wast increas atp synthesi effici via keton metabol pathway block abnorm cori cycl | D000230;D019042 | T191 |
36,230,948 | modul alveolar macrophag postimmunobiot impact tlr mediat antivir respiratori immun benefici microb immunomodulatori capac immunobiot non viabl form postimmunobiot could effect util formul toward prevent respiratori viral infect studi novel immunobiot strain abil increas antivir immun porcin alveolar macrophag select librari lactobacillus gasseri postimmunobiot deriv remark strain also evalu capac modul immun respons trigger toll like receptor tlr alveolar macrophag differenti regul tlr mediat antivir respiratori immun infant mice provid evid porcin alveolar macrophag cell use vitro tool screen new antivir immunobiot postimmunobiot assess abil modul express ifn ifn rnasel mx il use prospect biomark also demonstr postimmunobiot deriv lactobacillus gasseri tmt tmt tmt hk hk hk strain modul innat antivir immun respons alveolar macrophag reduc lung inflammatori damag trigger tlr activ vivo although find deepen expand result present work provid scientif rational use nasal administ hk hk hk benefici modul tlr triggerd respiratori innat immun respons | D016676;D051196 | T025;T116;T192 |
36,230,947 | progress salicyl acid depend signal growth defens trade one grand challeng studi plant biotic abiot stress respons optim plant growth plastic variabl environment constraint long run benefit agricultur product howev effort promot plant immun often accompani compromis morpholog syndrom growth retard steril reduc yield trade dictat complex signal driven secondari messeng phytohormon salicyl acid sa well known phytohormon essenti basal immun system acquir resist interest recent updat suggest extern environment cue nutrient status development stage primari metabol breed strategi attribut addit layer control sa depend signal henc plant perform pathogen review extern intern factor summar focus specif role sa biosynthesi downstream signal lead immun consider futur opportun highlight improv plant fit minim growth compens | D010937;D020156 | T121;T109;T116;T125 |
36,230,946 | speci specif gamet interact sea urchin fertil role egg jelli vitellin layer sea urchin sequenc cellular molecular event character fertil process intens studi learn activ egg fertil sperm must undergo morpholog modif acrosom reaction ar upon reach outer gelatin layer envelop egg egg jelli trigger polymer f actin sperm head form acrosom process ar expos bindin adhes sperm protein essenti speci specif interact cognat receptor egg vitellin layer investig specif role egg jelli vitellin layer fertil sea urchin egg paracentrotus lividus egg incub acid seawat remov egg jelli ie experiment condit prevent occurr ar insemin medium varianc prevail view result shown dejelli p lividus egg still interact sperm acid seawat albeit alter fertil respons particular egg depriv vitellin layer react multipl sperm alter ca signal result provid experiment evid plasma membran vitellin layer specif recognit gamet occur vitellin layer work unfertil egg prevent polyspermi | D000199;D012661 | T031;T123;T116 |
36,230,945 | preliminari develop test c radioimmunoconjug target muc cancer epitop pancreat ductal adenocarcinoma mucin transmembran glycoprotein overexpress cancer specif epitop muc ce pancreat ductal adenocarcinoma pdac cell pdac low surviv high aggress malign develop radioimmunoconjug capabl target muc ce could lead improv pdac outcom aim studi develop perform preliminari test diagnost therapeut radioimmunoconjug pdac use anti muc antibodi c first p scn bn dota conjug c antibodi form dota c immunoconjug stabil bind affin dota c conjug evalu use mass spectrometri elisa dota c radiolabel copper lutetium gallium technetium form novel radioimmunoconjug cell bind assay perform panc strong muc ce express aspc weak muc ce express cell line use cu dota c lu dota c optim molar ratio dota group per c molecul obtain conjug process dota c label copper lutetium technetium high effici although gallium label low lu dota c demonstr high cellular bind panc cell line signific greater aspc bind concentr exceed nm p lt cu dota c show similar bind panc aspc cell signific differ observ cell line p gt high cellular bind lu dota c muc ce posit cell line suggest promis therapeut radioimmunoconjug pdac work requir har potenti cu dota c diagnost radioimmunoconjug | D021441;D018796;D010190 | T191;T121;T129 |
36,230,944 | explor n methyladenosin profil mrnas function mettl atherosclerosi n methylladenosin modif fulli studi atherosclerosi object studi investig differenti express methyl peak mrnas along regulatori role methyltransferas mettl patholog process atherosclerosi | D050197;D008780 | T047;T046;T126;T116 |
36,230,943 | valid discrimin signatur obstruct sleep apnea exhal breath rapid reliabl tool diagnosi monitor obstruct sleep apnea osa current lack prior studi use chemic analysi exhal breath suggest exist osa specif metabol signatur valid diagnost approach propos marker compound well potenti reliabl diagnos osa cross section observ studi exhal breath analyz use secondari electrospray ionize high resolut mass spectrometri studi cohort includ untreat osa patient osa patient treat continu posit airway pressur healthi subject robust previous report osa marker valid base detect signific differ group mann whitney u test classif perform breath analysi particip result previous report marker could confirm independ valid cohort nine marker signific increas untreat osa compar treat osa subset consist previous valid studi osa predict base confirm osa signatur perform auc accuraci sensit specif sever breath marker clear found repeat robust independ valid studi result underscor clinic potenti breath analysi osa diagnost monitor | D045853;D020181 | T047;T040 |
36,230,942 | potenti moringa oleifera amelior haart induc pathophysiolog complic high activ antiretrovir therapi haart compris combin two three antiretrovir arv drug administ togeth singl tablet drug target differ step within human immunodefici virus hiv life cycl provid either synergist addit antivir effect enhanc effici viral replic suppress hiv complet elimin make haart lifetim treatment long term haart usag increas number patient experi broaden array complic signific affect qualiti life despit cautious use mechan arv drug induc toxic associ metabol complic mitochondri dysfunct oxid stress inflamm address necessari improv arv drug formul without compromis efficaci altern safe supplementari medicin may suitabl solut medicin plant moringa oleifera mo consid one import sourc novel nutrit pharmacolog activ compound shown prevent treat various diseas mo leav rich polyphenol vitamin miner tannin studi confirm therapeut properti mo mo leav provid power antioxid scaveng free radic promot carbohydr metabol repair dna mo also induc anti inflammatori hepatoprotect anti prolif anti mutagen effect therefor mo sourc afford safe supplement therapi haart induc toxic review highlight potenti mo leav protect haart induc toxic hiv patient | D016587;D015658;D029588 | T047;T002;T120;T039 |
36,230,941 | molecular mechan ferroptosi orthoped diseas ferroptosi new iron depend program cell death process direct mediat accumul lipid peroxid reactiv oxygen speci numer studi shown ferroptosi import regul occurr develop bone relat diseas under mechan complet clear herein review progress mechan ferroptosi bone marrow injuri osteoporosi osteoarthr osteosarcoma attempt deepli understand regulatori target ferroptosi open new way prevent treatment orthoped diseas | D000079403 | T043 |
36,230,940 | catr trace approach identifi individu intermediari neuron base input output proof concept studi connect cerebellum central hub implic development disord past decad becom increas clear mani neurodevelopment disord character aberr neuro anatom connectom intermediari hub yet despit advent unidirect transsynapt trace technolog still lack effici approach identifi individu neuron base precis input output relat hamper abil elucid precis connectom healthi diseas condit bridg gap combin anterograd transsynapt retrograd catr trace ai report mice use adeno associ virus serotyp express cre cholera toxin subunit b anterograd retrograd tracer respect appli innov approach select identifi individu neuron brainstem receiv input one cerebellar nuclei cn also project primari motor cortex amygdala ventral tegment area vta cell direct connect cn found main thalamus larg divers midbrain brainstem area connect cn amygdala vta data highlight catr allow specif yet brain wide identif individu neuron mediat inform cerebellar nucleus cerebr cortex amygdala vta via disynapt pathway given identifi neuron healthi subject readili quantifi data also form solid foundat make numer comparison mous mutant suffer aberr connectom due neurodevelopment disord | D002772;D002658 | T116;T131;T126;T048;T129 |
36,230,939 | dexra induc dysdifferenti oligodendrocyt myelin injuri inhibit camp creb pathway subarachnoid hemorrhag white matter damag wmd one research hotspot subarachnoid hemorrhag sah main manifest myelin injuri oligodendrocyt differenti disord sah although specif mechan remain unclear dexamethason induc ras relat protein dexra report involv nervous system damag autoimmun enceph multipl sclerosi howev whether dexra particip dysdifferenti oligodendrocyt myelin injuri sah yet examin reason creat research content articl intracerebroventricular lentivir administr use modul dexra level order determin function influenc neurolog injuri sah immunofluoresc transmiss electron microscopi western blot method use investig effect dexra demyelin glial cell activ differenti oligodendrocyt progenitor cell opc sah primari rat brain neuron treat oxyhemoglobin verifi associ dexra camp creb result show dexra level signific increas upon vivo sah model accompani opc differenti disturb myelin injuri dexra overexpress signific worsen opc dysdifferenti myelin injuri sah contrast dexra knockdown amelior myelin injuri opc dysdifferenti glial cell activ research under mechan discov camp creb pathway inhibit dexra overexpress vitro model sah studi first confirm dexra induc oligodendrocyt dysdifferenti myelin injuri sah inhibit camp creb pathway present research may reveal novel therapeut target amelior brain injuri neurolog dysfunct sah | D009186;D013345 | T046;T026;T024;T047 |
36,230,938 | dicam extracellular vesicl astrocyt attenu microglia activ neuroinflamm cross talk astrocyt microglia play import role neuroinflamm central sensit manner glial cell interact remain less well understood herein investig role dual immunoglobulin domain contain cell adhes molecul dicam glial cell interact neuroinflamm dicam knockout ko mice reveal enhanc nocicept behavior glial cell activ tibia fractur cast immobil model complex region pain syndrom crps dicam select secret reactiv astrocyt main via extracellular vesicl ev contribut regul neuroinflamm polar microglia depend suppress p mapk signal conclus dicam secret reactiv astrocyt ev involv suppress microglia activ subsequ attenu neuroinflamm central sensit | D001253;D000067128 | T025;T026 |
36,230,937 | retin pigment epithelium secret vegf induc alpha macroglobulin express endotheli cell alpha macroglobulin proteas inhibitor regul extracellular matrix ecm stabil turnov show express endotheli cell ec human eye choroid demonstr retin pigment epithelium rpe condit medium induc express specif ec experi use chemic inhibitor block antibodi recombin protein reveal key role vegf rpe mediat induct ec furthermor incub ec rpe condit medium reduc matrix metalloproteinas gelatinas activ cultur supernat partial restor knockdown ec propos dysfunct rpe choroid blood vessel observ retin diseas age relat macular degener may disrupt crosstalk mechan describ lead alter homeostasi choroid ecm bruch membran visual function | D045384;D055213 | T023;T123;T116 |
36,230,936 | alloster antagon pregnan x receptor pxr current state art predict novel alloster site pregnan x receptor pxr nri xenobiot activ transcript factor high level express liver play key role drug metabol elimin also promot tumor growth drug resist metabol diseas propos therapeut target type ii diabet metabol syndrom inflammatori bowel diseas pxr antagonist recent consid therapi colon cancer current pxr antagonist use clinic set nevertheless due larg complex ligand bind pocket lbp pxr challeng discov pxr antagonist orthoster site altern ligand bind site pxr also propos current studi recent af alloster bind site pxr identifi sever compound modul site discov herein aim summar current knowledg alloster modul pxr well attempt unlock novel alloster site describ novel bind function bf site pxr also common nuclear receptor addit also mention novel alloster site iii base silico predict identifi alloster site pxr provid new insight develop safe effici alloster modul pxr receptor therefor propos novel pxr alloster site might promis target treat chronic metabol diseas cancer | D003924;D011987 | T047;T116;T192 |
36,230,935 | metabol pathway breast cancer reprogram insight non code rnas cancer cell reprogram metabol achiev high energet requir produc precursor facilit uncontrol cell prolifer metabol reprogram involv dysregul glucos metabol regulatori enzym also enzym engag lipid amino acid metabol nevertheless under regulatori mechan reprogram fulli understood non code rnas ncrnas function rna molecul translat protein play regulatori role gene express moreov ncrnas demonstr implic metabol modul breast cancer bc regul metabol relat enzym focus regulatori involv ncrnas microrna circular rna long ncrna bc metabol includ glucos lipid glutamin metabol investig aspect may alter approach bc diagnosi prognosi may also open new avenu use ncrna base therapeut bc treatment target differ metabol pathway | D001943;D035683;D062085 | T191;T123;T114 |
36,230,934 | pcsk inhibit current advanc evolv futur proprotein convertas subtilisinkexin type pcsk secretori serin proteas synthes primarili liver main promot degrad low densiti lipoprotein receptor ldl r bind ldl r reduc low densiti lipoprotein cholesterol ldl c clearanc addit regul ldl r pcsk inhibitor also bind toll like receptor tlrs scaveng receptor b sr bcd low densiti lipoprotein receptor relat protein lrp apolipoprotein e receptor apoer low densiti lipoprotein receptor vldl r reduc lipoprotein concentr slow thrombosi addit cardiovascular diseas pcsk also use pancreat cancer sepsi parkinson diseas current market pcsk inhibitor includ alirocumab evolocumab inclisiran well small molecul nucleic acid drug vaccin develop review systemat summar applic preclin studi safeti mechan action latest research progress pcsk inhibitor aim provid idea drug research develop clinic applic pcsk cardiovascular diseas expand applic diseas | D002318;D009696 | T047;T123;T114 |
36,230,933 | treatment marmoset intracerebr hemorrhag human anti hmgb mab intracerebr hemorrhag ich recogn sever clinic problem lack effect treatment high mobil group box hmgb exhibit inflammatori cytokin like activ releas extracellular space nuclei previous demonstr intraven inject rat anti hmgb monoclon antibodi mab remark amelior brain injuri rat ich model therefor develop human anti hmgb mab oki clinic use present studi examin whether human anti hmgb mab amelior ich injuri common marmoset result show administr human anti hmgb mab inhibit hmgb releas brain plasma associ decreas hydroxynonen hne accumul decreas cerebr iron deposit addit human anti hmgb mab treatment result reduct brain injuri volum ich induct vitro experi show recombin hmgb inhibit hemoglobin uptak macrophag cd presenc haptoglobin suggest releas excess hmgb brain may induc delay hemoglobin scaveng therebi allow toxic effect hemoglobin heme fe persist final human anti hmgb mab reduc bodi weight loss improv behavior perform ich taken togeth result suggest intraven inject human anti hmgb mab potenti novel therapeut strategi ich | D001930;D002144 | T015;T037 |
36,230,932 | regul network non code rna associ cerna cisplatin induc acut kidney injuri cisplatin wide use chemotherapeut drug treat various solid tumor howev often induc sever side effect includ nephrotox limit applic clinic set furthermor under mechan action unclear appli whole transcriptom rna sequenc cisplatin induc acut kidney injuri cp aki mous model evalu compet endogen rna cerna network found mrnas long non code rnas circular rnas microrna signific differenti express cp aki control mice perform gene set enrich analysi reveal biolog function mrnas construct non code rna associ cerna network cp aki mice two cerna regulatori pathway lhxos mmu mir p slca circular rnammu mir p ptprn valid use quantit real time pcr protein protein interact network indic il cxcl cxcl plk serv hub gene high connect inflammatori respons dna damag transcript factor stat cebpb foxm regul gene express level cp aki studi provid insight non code rna associ cerna network mrnas cp aki identifi potenti treatment target | D058186;D035683 | T047;T123;T037;T114 |
36,230,931 | hiv infect long live hematopoiet precursor vitro vivo latent reservoir human immunodefici virus hiv infect individu repres major obstacl find cure hiv hematopoiet stem progenitor cell hspcs describ potenti hiv target role hiv reservoir remain controversi provid addit evid suscept sever distinct hspc subpopul hiv infect vitro vivo vitro infect experi hspcs perform differ hiv env pseudotyp lentivir particl replic compet hiv low level infectiontransduct hspcs includ hematopoiet stem cell hscs multipot progenitor mpp observ preferenti via cxcr also via ccr mediat entri multi lineag coloni format methylcellulos assay repetit replat transduc cell provid function proof suscept primit hspcs hiv infect access bone marrow sampl hiv posit individu facilit detect hiv gag cdna copi cd cell eight eleven individu least six infect ccr tropic hiv strain summari data confirm primit hspc subpopul suscept cxcr ccr mediat hiv infect vitro vivo qualifi cell contribut hiv reservoir patient | D015658;D015497 | T047;T005 |
36,230,930 | nsp orfb sar cov induc pro inflammatori mitochondri dna releas inner membran deriv vesicl circul cell free mitochondri dna cf mtdna found plasma sever ill covid patient known strong predictor mortal howev under mechan mtdna releas unexplor show novel mechan sar cov mediat pro inflammatorypro apoptot mtdna releas ration therapeut stem cell base approach mitig effect systemat screen effect sar cov protein mitochondri damag cell death found nsp orfb caus extens mitochondri structur chang outer membran macropor format releas inner membran vesicl load mtdna macropor form abil nsp mediat interact bcl antagonistkil bak wherea orfb found inhibit anti apoptot member bcl famili protein myeloid cell leukemia mcl induc inner membran vesicl format contain mtdna knockdown bak andor overexpress mcl signific revers sar cov mediat mitochondri damag therapeut engin human mesenchym stem cell mscs simultan knockdown bak overexpress mcl mscshbakmcl name cell imat mscs intercellular mitochondri transfer assist therapeut mscs upon co cultur sar cov infect nsporfb transduc airway epitheli cell imat mscs display function intercellular mitochondri transfer imt via tunnel nanotub tnts mitochondri donat imat mscs attenu pro inflammatori pro apoptot mtdna releas co cultur epitheli cell find thus provid new mechanist basi sar cov induc cell death novel therapeut approach engin mscs treatment covid | D000086382;D004272 | T047;T123;T067;T114 |
36,230,929 | micro rnaa p inhibit breast cancer cell driven growth vascular endotheli cell alter secretom inhibit mitogenesi transcriptom function evid breast cancer bc cell secretom tumor microenviron tme facilit neo angiogenesi promot vascular endotheli cell vec growth drug block bc cell growth angiogenesi restrict tumor growth clinic relev molecul target bc cell vec growth well bc secretom may effect treat bc sinc small non code microrna mir regul cell growth mira p onco suppressor activ investig whether mira p inhibit mcf driven growth prolifer migrat capillari format signal transduct vec use bc cell vec grown monolay spheroid gene microarray demonstr pro growth effect mcf mda mb condit medium cm lost cm collect mcf mda mb cell pre transfect mira p mira cm moreov mira cm inhibit mapk akt phosphoryl vec microarray gene express studi mira cm upregul gene downregul gene vec transcriptom pathway enrich analysi differenti regul gene reveal downregul interferon associ gene pathway induc angiogenesi bctumor growth angiogenesi proteom array confirm downregul pro angiogenesi protein mira cm vec addit mcf cell vec estradiol e downregul mira p express induc growth ectop express mira p abrog growth stimulatori effect estradiol e serum mcf cell vec well mcf mcf vec spheroid immunostain mcf vec spheroid section ki show mira p inhibit cell prolifer taken togeth find provid first evid mira p abrog mcf driven growth vec alter mcf secretom downregul pro growth interferon signal proangiogen protein addit mira p inhibit serum e induc growth mcf vec mcf vec spheroid conclus mirnaa p potenti targetinhibit bc tumor angiogenesi via dual mechan alter proangiogen bc secretometm inhibit vec growth may repres therapeut molecul target breast tumor growth | D001943;D035683 | T191;T123;T114 |
36,230,928 | trace translat footprint ribo seq principl workflow applic understand mechan human diseas rna seq wide use high throughput method character transcript dynam chang broad context develop diseas howev whether rna seq estim transcript dynam translat protein level chang larg unknown ribo seq ribosom profil emerg technolog allow investig translat footprint via profil ribosom bound mrna fragment ribo seq coupl rna seq allow us understand transcript translat control fundament biolog process human diseas review focus discuss principl workflow applic ribo seq studi human diseas | D012270 | T026 |
36,230,927 | stage depend activ pro chondrogen function pikakt cartilag neogenesi mesenchym stromal cell differenti mesenchym stromal cell mscs articular chondrocyt ac applic clinic cartilag regener requir profound understand signal pathway regul stem cell chondrogenesi hypertroph degener classifi endochondr signal driver chondrogen speed versus hypertrophi focus insulininsulin like growth factor igf induc phosphoinositid kinas pik akt signal awar prolif function earli late msc chondrogenesi aim unravel late pro chondrogen versus pro hypertroph pikakt role pikakt activ human msc ac chondrogen cultur assess via western blot detect phosphoryl akt effect pik inhibit ly chondrogenesi hypertrophi assess via histolog qpcr quantif proteoglycan alkalin phosphatas activ repress ac pikakt activ transient rose differenti mscs independ tgf endogen bmpwnt activ climax around day pikakt inhibit day equal reduc chondrocyt hypertrophi marker prove import tgf induc smad phosphoryl sox accumul pikakt activ identifi requir stage depend driver chondrogen speed hypertrophi thus futur attempt improv msc chondrogenesi depend adequ stimul upregul pikakt activ generat high qualiti cartilag human mscs | D061385;D059630 | T121;T025 |
36,230,926 | crispr base therapeut gene edit duchenn muscular dystrophi advanc challeng perspect duchenn muscular dystrophi dmd sever neuromuscular diseas aris loss function mutat dystrophin gene character progress muscl degener respiratori insuffici cardiac failur prematur death age thirti albeit dmd one common type fatal genet diseas curat treatment devast disord recent year gene edit via cluster regular interspac short palindrom repeat crispr system pave new path toward correct patholog mutat genet sourc thus enabl perman restor dystrophin express function throughout musculatur date therapeut benefit crispr genom edit system success demonstr human cell rodent canin piglet divers dmd mutat nevertheless remain nonignor challeng solv clinic applic crispr base gene therapi herein provid overview therapeut crispr genom edit system summar recent advanc applic dmd context discuss sever potenti obstacl lie ahead clinic translat | D016189;D020388 | T047;T123;T116 |
36,230,925 | hiv associ insult modul adam regul sirtuin nmda receptor depend manner neurolog deficit associ human immunodefici virus hiv infect impact person hiv pwh disord term hiv associ neurocognit disord hand possess neuropatholog similar alzheim diseas ad includ intra extracellular amyloid beta peptid aggreg peptid produc cleavag amyloid precursor protein app beta secretas bace howev preclud cleavag app non amyloidogen alpha secretas adam previous studi found bace express increas cns pwh hand well anim model hand bace contribut neurotox yet vitro model role adam potenti regulatori mechan examin address primari rat cortic neuron treat supernat hiv infect human macrophag hivmdm found hivmdm decreas level adam sirtuin sirt regul adam implic age ad decreas block nmda receptor antagonist treatment nmda suffici induc reduct adam sirt protein level furthermor decreas sirt protein level observ earlier time point decreas adam protein level reduct sirt revers proteasom inhibitor mg studi indic hiv associ insult particular excitotox contribut chang app secretas downregul level adam regul | D000544;D015658 | T047;T048 |
36,230,924 | complex relat atrial cardiomyopathi thrombogenesi heart diseas well system metabol alter leav fingerprint structur function chang atrial myocardium lead onset atrial cardiomyopathi demonstr various anim model chang fibrosi cardiomyocyt hypertrophi fatti infiltr increas vulner atrial fibril af relev manifest atrial cardiomyopathi clinic practic atrial cardiomyopathi accompani af associ thromboembol event stroke interact af stroke appear far complic initi believ af stroke share mani risk factor whose under patholog process reinforc develop progress cardiovascular condit review summar main mechan atrial cardiomyopathi preced af support thrombogen event within atrial caviti myocardi interstiti space moreov report pleiotrop effect activ coagul factor atrial remodel may aggrav atrial cardiomyopathi final address complex associ af stroke explain multidirect causal relat atrial cardiomyopathi hypercoagul | D001281;D009202;D020521 | T047;T046 |
36,230,923 | diagnost potenti microrna extracellular vesicl deriv bronchoalveolar lavag fluid pneumonia preliminari report current clinic need requir develop use rapid effect diagnost indic acceler identif pneumonia process microbiolog diagnosi microrna mirna extracellular vesicl ev becom attract candid novel biomark evalu presenc progress mani diseas assess perform biomark pneumonia patient divid pneumonia group pneumonia control group without pneumonia identifi compar two upregul mirna ev deriv bronchoalveolar lavag fluid balf ev two group p mir p p mir p interest cell debri pellet ev free supernat deriv bronchoalveolar lavag fluid balf cell debri pellet balf ev free supernat total plasma ev deriv plasma plasma ev express mir p mir p show differ pneumonia group control group vitro experi reveal mir p mir p strike upregul ev deriv macrophag stimul lipopolysaccharid mir p area curv auc mir p auc balf ev inferior procalcitonin auc diagnosi pneumonia furthermor mir p mir p balf ev signific higher specif compar procalcitonin could serv potenti diagnost marker mir p mir p ev may involv lung inflamm influenc forkhead box foxo signal pathway protein process endoplasm reticulum studi one studi focus potenti diagnost role mirna balf ev pneumonia possibl use new biomark rapid earli diagnosi | D000067128;D035683;D011014 | T050;T047;T026;T123;T114 |
36,230,922 | bioinformat function analysi new nuclear local sequenc influenza virus nucleoprotein influenza virus deliv genom nucleus infect cell replic process mediat viral nucleoprotein np contain two nuclear local sequenc nlss nls n terminus recent identifi nls grktr mutagenesi function studi demonstr np must nlss effici nuclear import nlss may variat basic residu nls differ strain virus may affect nuclear import viral genom although nls variant fuse gfp mediat nuclear import gfp bioinformat show report np sequenc contain either wild type sequenc grktr grrtr bioinformat analys use studi presenc nls variant viral nuclear protein result low hit human nuclear protein contain putat nls studi nucleolar protein nop found nls play role nuclear import protein nucleolar local also discov function nls c terminus nop find indic nls high conserv influenza np sequenc | D019295;D019913 | T091;T087 |
36,230,921 | neuroinflamm dementia therapeut direct covid pandem set although dementia heterogen group diseas inflamm shown play central role provid common link patholog review aim highlight import immun respons common type dementia describ molecular aspect pro inflammatori signal sourc inflammatori activ human organ includ novel infecti agent sar cov role glial cell neuroinflamm well potenti therapeut approach discuss peripher immun respons increas cytokin product includ earli surg tnf il concentr activ glia lead aggrav neuroinflamm dysfunct neuron covid lifestyl factor diet larg impact futur cognit outcom includ crucial intervent dementia prevent use nsaid recommend due inconclus result efficaci risk side effect studi focus use tnf antagonist specif target neuroinflamm still limit still unknown degre neuroinflamm result covid may affect neurodegen process cognit function long term ongo report chronic post covid complic | D000086382;D003704 | T047;T067;T048 |
36,230,920 | time blood sampl process affect transcriptom epigenom profil cd cell atop subject optim pre analyt condit blood sampl process isol select cell popul subsequ transcriptom epigenom studi requir obtain robust reproduc result pilot studi conduct investig potenti effect time cd cell process peripher blood atop non atop adult transcriptom epigenet profil two heparin blood sampl drawn three atop three healthi individu individu cd cell isol first blood sampl within h immedi second blood sampl h storag delay rna sequenc rna seq histon hk acetyl chromatin immunoprecipit sequenc chip seq analys perform multipl gene shown differenti express immedi process cd cell atop versus healthi subject differ disappear compar delay process cell due drastic chang express level atopi relat gene delay process cd cell atop donor find valid epigenom level examin hk acetyl profil contrast transcriptom epigenom profil blood cd cell healthi donor remain rather unaffect taken togeth success transcriptom epigenom studi detail standard oper procedur develop basi sampl healthi diseas condit implicit recommend | D057890;D059467 | T091;T081;T086 |
36,230,919 | cork lrr malectin receptor kinas requir cellooligom induc respons arabidopsi thaliana cell wall integr cwi mainten central plant cell mechan chemic distort ph chang breakdown product cell wall polysaccharid activ plasma membran local receptor induc appropri downstream respons microbi interact alter destroy structur plant cell wall connect cwi mainten immun respons cellulos major polysaccharid primari secondari cell wall breakdown generat short chain cellooligom induc ca depend cwi respons show respons requir malectin domain contain cellooligom receptor kinas cork arabidopsi preferenti activ cellotrios ct cork requir cellooligom induc cytoplasm ca elev reactiv oxygen speci ros product mitogen associ protein kinas mapk activ cellulos synthas phosphoryl regul cwi relat gene includ involv biosynthesi cell wall materi secondari metabolit tryptophan phosphoproteom analys identifi earli target involv signal cellulos synthesi endoplasm reticulumgolgi secretori pathway cell wall repair immun respons two conserv phenylalanin residu malectin domain crucial cork function propos cork requir cwi immun respons activ cellulos breakdown product | D017360 | T002 |
36,230,918 | therapeut drug induc metabol reprogram glioblastoma glioblastoma iv gbm common primari brain tumor adult heterogen malign display reprogram metabol various fuel sourc dispos tumor cell primarili appear consum glucos entertain anabol catabol metabol less effect energi product aerob glycolysi warburg effect effect mean drive biosynthesi critic molecul requir relentless growth resist cell death target warburg effect may effect venu cancer treatment howev past recent evid highlight approach may limit scope gbm cell possess metabol plastic allow har substrat includ limit fatti acid amino acid lactat acet review recent key find literatur highlight gbm cell substanti reprogram metabol upon therapi studi suggest block glycolysi yield concomit reactiv oxid energi pathway domin beta oxid fatti acid | D005909 | T191 |
36,230,917 | could endogen glucocorticoid influenc sar cov infect endogen glucocorticoid synthet analogu dexamethason stimul receptor mediat signal transduct mechan target cell mechan result benefici outcom wherea other deleteri set pathogen infect immunolog disord review recent studi sever group includ group show glucocorticoid direct interact protein compon sar cov causat agent covid postul antivir defenc mechan endogen glucocorticoid eg cortisol produc respons sar cov infect bind multipl site sar cov surfac protein spike induc conform alter spike subunit inhibit sar cov interact host sar cov receptor ace suggest glucocorticoid mediat inhibit interact ace may consequ affect sar cov infect glucocorticoid interact spike could protect broad spectrum coronavirus variant util spike infect host notion may use design new antivir coronavirus diseas | D000086382 | T047;T067 |
36,230,916 | epigenet mechan postop cognit impair induc anesthesia neuroinflamm cognit impair surgeri common problem affect main elder divid postop delirium postop cognit dysfunct phenomena accompani neuroinflamm howev precis molecular mechan under cognit impair anesthesia yet fulli understood anesthesiolog drug longer term influenc protein transcript thus epigenet possibl mechan impact cognit function epigenet mechan may respons long last effect may implic novel therapeut approach henc summar exist literatur connect postop cognit impair anesthesia becom clear anesthet alter express dna histon modifi enzym turn affect epigenet marker methyl histon acetyl histon methyl inflammatori gene eg tnf alpha il il beta gene respons neuron develop brain deriv neurotroph factor neuroinflamm general increas anesthesia neuron growth decreas chang induc cognit impair inhibit histon deacetylas especi allevi cognit impair surgeri might novel therapeut option treatment howev research human subject necessari find anim model | D000758;D060825;D003693;D000079690 | T061;T048 |
36,230,915 | cartilagin metabolom reveal biochem nich fate control bone marrow deriv stem cell joint disord becom global health issu growth age popul screen small activ molecul target chondrogen differenti bone marrow deriv stem cell bmscs urgenc studi microfractur employ creat regen nich rabbit n cartilag sampl collect four week post surgeri microfractur caus morpholog n metabol n chang detect non target metabolom analysi reveal differenti express metabolit dem enrich pathway involv anti inflamm lipid metabol signal transduct etc among metabolit docosapentaeno acid n dpa ursodeoxychol acid udca function facilit cartilag defect heal ie increas vital adapt bmscs chondrogen differenti chondrocyt function find first reveal differ metabolom activ normal regener cartilag provid list endogen biomolecul potenti involv biochem nich fate control chondrogen differenti bmscs ultim biomolecul may serv anti age supplement chondrocyt renew drug candid cartilag regen medicin | D015775;D059630 | T025;T046;T037 |
36,230,914 | role tumor microenviron regul pancreat cancer therapi resist pancreat cancer notori poor prognosi exhibit persist drug resist lack cure uniqu featur pancreat tumor microenviron exacerb tumorigenesi metastasi therapi resist recent studi emphas import exploit cell tumor microenviron thwart cancer review summar hallmark multifacet pancreat tumor microenviron notabl pancreat stellat cell tumor associ fibroblast macrophag neutrophil regul chemo radio immuno target therapi resist pancreat cancer molecular insight facilit develop novel therapeut pancreat cancer | D010190;D059016 | T191;T070 |
36,230,913 | macrophag mediat inflamm skin wound heal macrophag key immun cell respond infect modul pathophysiolog condit wound heal possess phagocyt activ secret cytokin growth factor macrophag pivot orchestr inflamm fibrosi wound repair macrophag orchestr process wound heal transit predomin pro inflammatori like phenotyp present earli post injuri anti inflammatori like phenotyp appear later modul skin repair wound closur review differ cellular molecular aspect macrophag mediat skin wound heal discuss alongsid import aspect macrophag subtyp metabol plastic epigenet also highlight previous studi demonstr interact macrophag factor optim wound heal understand har activ capabl macrophag may help advanc new approach improv heal skin | D008264;D014945 | T025;T040 |
36,230,912 | singl cell gene express analysi reveal immun cell signatur delta covid coronavirus diseas covid accompani cytokin storm releas mani proinflammatori factor develop respiratori syndrom sever sar cov lineag identifi delta variant b link high mortal risk becom domin mani countri understand immun respons associ covid lineag may therefor aid develop therapeut diagnost strategi multipl singl cell gene express studi reveal innat adapt immunolog factor pathway correl covid sever addit investig cover host pathogen respons characterist infect caus differ lineag requir perform singl cell transcriptom profil blood mononuclear cell individu differ sever covid virus lineag uncov variant specif molecular factor associ immun identifi signific chang lymphoid myeloid cell studi highlight abund popul monocyt specif gene express signatur accompani delta lineag sar cov contribut covid pathogenesi infer immun compon target therapi | D000086382 | T047;T067 |
36,230,911 | ga ga pentixafor sodium f fluorid pet non invas identifi monitor dynam orthodont tooth movement mous model cellular molecular mechan orthodont tooth movement otm yet fulli understood part due lack dynam dataset within subject inflamm calcif two main process otm given high sensit specif ga ga pentixafor sodium f fluorid na f f inflamm calcif respect aim studi assess abil identifi monitor dynam otm establish mous model monitor process otm real time anim scan use small anim petct week post implant ga ga pentixafor na f f tracer show increas uptak region interest compar control ga ga pentixafor increas uptak observ within week trial suggest continu presenc inflammatori marker na f f show increas uptak trial indic intensif bone remodel interim end experi histolog assess visualis increas amount chemokin receptor cxcr trap posit cell periodont ligament compress side approach establish first vivo model periodont remodel otm effici detect monitor intric dynam periodont ligament | D005710;D000072078 | T060;T196 |
36,230,910 | loss homeostat microglia signatur prion diseas prion diseas neurodegen diseas affect human anim alway fatal date treatment exist hallmark prion diseas pathophysiolog misfold endogen protein cellular prion protein prp c diseas associ isoform prp sc besid aggreg deposit misfold prp sc prion diseas character spongiform lesion activ astrocyt microglia microglia innat immun cell brain activ microglia astrocyt repres common patholog featur neurodegen disord role activ microglia alreadi studi prion diseas mous model howev still fulli clear contribut diseas progress moreov role microglia human prion diseas thorough investig thus far specif molecular pathway still undetermin review current knowledg differ role microglia prion pathophysiolog discuss microglia marker also dysregul neurodegen diseas includ microglia homeostasi marker data murin human brain tissu show microglia high dysregul prion diseas highlight loss homeostat marker may especi stand | D019636;D017096;D011328 | T047;T116;T005 |
36,230,909 | win modul intracellular calcium via cb receptor depend independ mechan neuroblastoma cell cb cannabinoid receptor cb r extracellular calcium eca stimul calcium sens receptor casr exert cellular signal modul level intracellular calcium ca investig mechan involv ca increas ntg neuroblastoma cell endogen express receptor chang ca measur cell expos mm eca ratiometr method fura fluoresc express differ baselin peak respons f increas ca cell expos mm eca block casr antagonist nps inhibit abrog upon stimul win win increas ca mm eca respect increas replic cp methyl anandamid store oper calcium entri soce blocker mrs attenu win stimul increas ca level eca simultan perfus cb antagonist sr nps decreas respons win mm mm eca co perfus non cb cb antagonist attenu win stimul ca increas eca level result consist win mediat intracellular ca mobil store oper calcium channel fill sourc could occur via either cb r sensit non cb r coordin casr intracellular pathway crosstalk signal protein complex may explain observ effect | D002118;D009447 | T121;T191;T123;T196 |
36,230,908 | endotheli mesenchym transit atherosclerosi friend foe despit mani decad research complic atherosclerosi result ruptur eros unstabl plaqu remain lead caus death worldwid advanc cellular lineag trace techniqu allow research begin investig role individu cell type key process regul plaqu stabil includ mainten fibrous cap protect collagen rich structur under endothelium structur previous thought entir deriv smooth muscl cell smc migrat vessel wall howev recent lineag trace studi identifi endotheli cell ec essenti compon protect barrier endotheli mesenchym transit endomt process previous implic pulmonari cardiac kidney fibrosi although presenc endomt atherosclerot plaqu shown sever laboratori use ec lineag trace mous model whether endomt detriment ie worsen diseas progress benefici ie athero protect respons prevent plaqu instabl remain uncertain data support possibl discuss review | D050197;D058226 | T031;T047;T046;T020 |
36,230,907 | bio engin scaffold deriv decellular human esophagus function organ reconstruct esophag reconstruct bio engin allograft high resembl peculiar properti tissu extracellular matrix ecm prospect strategi overcom limit current surgic approach work human esophagus decellular first time literatur compar three deterg enzymat protocol decellular residu dna quantif histolog analys show protocol effici remov cell dna lt ngmg tissu muscl fiber preserv collagenelastin compon glycosaminoglycan fraction maintain decellular versus nativ tissu immunohistochemistri show unchang express specif ecm marker collagen iv laminin proteom signatur acellular esophagi corrobor retent structur collagen basement membran matrix cell interact protein convers decellular led loss hla dr express produc non immunogen allograft accord hydroxyprolin quantif matrix collagen preserv gmg tissu decellular second harmon generat imag highlight decreas collagen intens base uniaxi tensil test decellular affect tissu stiff sampl integritymanipul still maintain final cytotox test reveal harm remnantscontamin present acellular esophag matric suggest allograft biosafeti despit differ outcom show three decellular method regard exampl tissu manipul dna remov glycosaminoglycanshydroxyprolin content ultim valid provid futur repopul test vivo orthotop implant esophag scaffold | D003902;D004549 | T116;T073;T120;T121;T123 |
36,230,906 | pgc interact rest upregul neuron gene augment energi consumpt develop cardiomyocyt transcript coactiv pgc main regul cardiac energi metabol addit canon pgc pgc isoform found exert specif biolog function varieti tissu investig express pattern biolog effect non canon isoform heart use rna sequenc data identifi express pattern pgc isoform heart evalu biolog effect altern isoform express generat transgen mous cardiac specif overexpress pgc analys cardiac phenotyp wide spectrum physiolog biophys tool result show non canon isoform express heart main variant pgc induc adrenerg signal adult cardiomyocyt cardiomyocyt specif pgc overexpress mice reliev silenc transcript factor rest mediat suppress neuron gene foetal heart develop result de repress rest target gene induc cardiac phenotyp increas cellular energi consumpt result postnat dilat cardiomyopathi result propos new concept action pgc protein famili activ pgc gene isoform induc phenotyp concurr suppli demand cellular energi data highlight biolog role differ pgc isoform consid futur therapi develop | D018482;D032383 | T023;T024;T025 |
36,230,905 | rna bind landscap hax protein indic involv translat ribosom assembl hax human protein known homologu structur domain mutat hax gene caus sever congenit neutropenia mechan poor understood previous studi report rna bind capac hax role bind physiolog patholog remain unexplain report transcriptom wide character hax rna target use rip seq crac indic hax bind transcript involv translat ribosom biogenesi rrna process use crispr knockout find hax rna target partial overlap transcript downregul hax ko impli role mrna stabil gene ontolog analysi demonstr gene differenti express hax ko includ gene involv ribosom biogenesi translat also enrich subset gene whose express correl hax express four analyz neoplasm function connect ribosom biogenesi also demonstr gradient sediment ribosom profil reveal differ small subunit monosom ratio hax wtko specul chang hax express may import etiolog hax link diseas dysregul translat | D011506;D012270 | T026;T123;T116 |
36,230,904 | comparison differ clinic chemotherapeut agent toxic cell respons mesenchym stem cell cancer cell mesenchym stem cell mscs fibroblast one abund cell type tumor microenviron tme exert various anti pro apoptot effect tumorigenesi invas drug treatment despit recent discov import mscs tumor progress therapi respons cell chemotherapeut compar cancer cell rare investig wide accept view naiv mscs higher drug toler cancer cell due signific lower prolifer rate examin differ similar sensit mscs cancer cell nine divers chemotherapi agent show although mscs slower cell cycl cell still sensit various drug surpris mscs show similar sensit panel compound howev suffer fewer dna doubl strand break enter senesc state virtual incap apoptosi result suggest mscs cancer cell differ cell fate drug treatment could influenc therapi outcom find could help design drug combin target mscs cancer cell tme | D000970;D059630 | T121;T025;T109 |
36,230,903 | advanc biomark endogen regul breast cancer stem cell breast cancer one common cancer even breast cancer patient initi respond treatment develop resist lead poor prognosi cancer stem cell cscs group undifferenti cell self renew multipot differenti characterist exist evid shown cscs one determin contribut heterogen primari tumor emerg cscs caus tumor recurr metastasi therapeut resist previous studi indic differ stem associ surfac marker identifi breast cancer stem cell bcsc subpopul deciph critic signal network involv induct mainten stem essenti develop novel bcsc target strategi review review biomark bcscs critic regul bcscs signal network regul stem bcscs | D001943 | T191 |
36,230,902 | long noncod rnas circular rnas regul akt effector control cell function cancer cell akt serin threonin kinas akt effector essenti maintain cell prolifer apoptosi autophagi endoplasm reticulum er stress mitochondri morphogenesi fissionfus ferroptosi necroptosi dna damag respons damag repair senesc migrat cancer cell sever lncrnas circrna also regul express function numer pathway howev impact cell function lncrnas circrna regul akt effector poor understood review provid comprehens inform relationship lncrnas circrna akt cell function cancer cell role sever lncrnas circrna act akt effector foxo mtorc sk ebp srebp hif explor valid relationship akt akt effector lncrnas circrna predict akt akt effector target lncrnas circrna retriev lnctard circbas databas consist use depth literatur survey akt akt effector target databas lncrnas circrna relat cell function therefor lncrnas circrna regul sever cell function modul akt akt effector review provid insight comprehens network akt akt effector connect lncrnas circrna regul cancer cell function | D009369;D062085 | T191;T123;T114 |
36,230,901 | locus specif enrich analysi hydroxymethylcytosin reveal novel gene associ breast carcinogenesi imbal dna methyl hallmark epigenet alter cancer convers methylcytosin mc hydroxymethyl cytosin hmc caus imbal result aberr gene express precis function role hydroxymethylcytosin breast cancer remain elus studi describ landscap mc hmc associ breast cancer develop found distinguish global loss hmc local invas type breast cancer strong correl tet express genom wide analysi reveal uniqu mc hmc signatur breast cancer differenti methyl region dmrs primarili concentr proxim regulatori region promot utr differenti hydroxymethyl region dhmrs dens pack distal regulatori region intergen region gt kb tsss result indic dmrs dhmrs associ breast cancer valid nine hmc enrich loci distinct set breast cancer normal sampl posit correl correspond gene express novel hmc candid txnl cnih implic pro oncogen role breast cancer overal result provid new insight loci specif accumul mc hmc aberr methyl demethyl breast cancer | D044503;D001943 | T191;T123;T114 |
36,230,900 | function repercuss hypoxia induc factor idiopath pulmonari fibrosi hypoxia hypoxia induc factor hif essenti regul sever cellular process surviv differenti cell cycl adapt orchestr complex way review focus impact hypoxia physiopatholog idiopath pulmonari fibrosi ipf relat lung develop regener repair robust evid respons hif differ hif particip main acut phase respons hypoxia hif chronic phase analysi structur differ studi show high specif accord tissu process involv propos hypoxia induc transcript factor hif part persist aberr regener associ develop ipf | D051792;D054990 | T047;T123;T116 |
36,230,899 | nicotin receptor polymorph rs associ airway remodel inflammatori dysregul copd patient genom wide associ studi unveil associ singl nucleotid polymorph rs chrna encod nicotin acetylcholin receptor alpha subunit snp nicotin addict cancer copd independ investig snp induc epitheli remodel inflammatori respons human copd airway includ snp copd patient wild type copd patient multi modal studi compar histolog analysi perform formalin fix paraffin embed lung tissu isol airway epitheli cell bronchial brush cultiv air liquid interfac broncho alveolar fluid collect detect inflammatori mediat ciliogenesi alter snp copd bronchial bronchiolar epithelia goblet cell hyperplasia exacerb snp small airway broncho alveolar fluid snp copd patient exhibit increas inflammatori mediat involv rs polymorph airway epitheli remodel relat inflammatori respons copd prompt develop innov person diagnost therapeut strategi | D029424 | T047 |
36,230,898 | counteract novel hydroalcohol extract len culinaria dexamethason induc osteoblast loss nativ murin cell cytoprotect effect novel hydroalcohol extract mgml len culinaria terr di altamura srl investig within murin nativ skelet muscl fiber bone marrow cell osteoblast cell line treat apoptot agent staurosporin alkyl drug cisplatin topoisomeras inhibitor irinotecan antimitot pro oxid doxorubicin immunosuppress dexamethason amount g plant materi use obtain ethanolwat product follow two step extract evapor lyophil storag c murin osteoblast doxorubicin reduc surviv dexamethason h incub time respect extract effect prevent osteoblast count reduct induc dexamethason also effect prevent inhibit miner induc dexamethason doxorubicin cisplatin caus signific reduct cell growth bone marrow cell irinotecan dexamethason evid cytoprotect effect extract cell staurosporin doxorubicin caus fiber death rate gt h incub yet extract effect prevent effect extract effect prevent staurosporin induc reduct hek prolifer coloni format crystal violet dna stain clonogen assay also effect cisplatin induc reduct hek cell prolifer extract howev fail protect shsyy neuron cisplatin irinotecan induc cytotox uvvi spectroscopi analysi show three peak wavelength nm correspond flavonoid proanthocyanin salicyl aa constitut extract data suggest possibl develop extract use dexamethason induc bone loss renal chemotherapi induc damag | D050256;D003907 | T121;T109 |
36,230,897 | ppar agonist promot type ii cartilag format rabbit osteochondr defect model osteoarthr oa chronic degen joint diseas accompani inflammatori milieu result pain joint pathogenesi oa multifactori genet predisposit environment factor traumat injuri result direct indirect loss cartilag articular cartilag also damag direct focal traumat injuri articular cartilag provid smooth deform bear surfac low coeffici friction increas contact area reduc contact stress articular type ii hyalin cartilag line synovi joint injur limit abil repair except superfici layer via diffus synovi fluid secondari blood suppli complex structur low metabol rate restor articular surfac reliev pain restor function although mani strategi develop regener type ii collagen base extent lesion surgic treatment still evolv peroxisom prolifer activ receptor delta ppar agonist collagen treatment mesenchym stem cell mscs enhanc chondrogen capac vitro present novel techniqu cartilag restor rabbit cartilag osteochondr defect model use ppar agonist gw infus collagen scaffold induc type ii cartilag mscs | D002358;D010003;D047494 | T047;T024;T116;T192 |
36,230,896 | systemat annot reveal cep function tomato root develop abiot stress respons tomato solanum lycopersicum one import veget crop worldwid howev environment stressor sever restrict tomato growth yield therefor great interest discov novel regul improv tomato growth environment stress adapt appli comprehens bioinformat approach identifi putat tomato c termin encod peptid cep gene explor potenti physiolog function tomato root develop abiot stress respons total tomato cep gene identifi group two subgroup base similar cep motif public rna seq data reveal tomato cep gene display divers express pattern tomato tissu addit cep gene express differenti regul nitrat ammonium status root shoot respect differ express level cep gene induc nitrogen indic potenti involv cep tomato nitrogen acquisit synthet cep peptid promot tomato primari root growth requir nitric oxid calcium signal furthermor also reveal cep peptid improv tomato root resist salin overal work contribut provid novel genet breed strategi tomato cultiv advers environ | D064751;D018551 | T002;T104;T168;T197 |
36,230,895 | valid aac deriv peptid anti tumor activ singl graft szari patient deriv xenograft mous model szari syndrom ss aggress cutan cell lymphoma poor prognosi main character expans tumor cd cell clone skin blood far develop new therapeut strategi hinder lack reproduc vivo model close reflect patient clinic featur develop ss murin model consist intraven inject szari patient pbmc togeth mixtur interleukin nod scid gamma mice thirti four fifti day inject mice show skin disord similar observ patient detect epidermi thicken dermal tumor cell infiltr although experiment variabl observ szari cell could track blood stream confirm model could effici exhibit skin blood involv use model evalu therapeut potenti rt cell penetr peptid deriv surviv protein anti apoptosi clone aac previous character specif induc apoptosi szari patient malign clone ex vivo system administr rt led cutan tumor cell deplet demonstr effici malign cell target favor safeti profil preclin data confirm rt might innov therapeut tool szari syndrom | D057846;D012751;D012878 | T191;T116 |
36,230,894 | circul microparticl differenti increas lowland highland high altitud induc pulmonari hypertens cold season role microparticl mps cold high altitud pulmonari hypertens haph remain unexplor investig impact long term cold exposur pulmonari circul lowland high altitud nativ role mps pulmonari hemodynam evalu use doppler echocardiographi end colder warmer season examin mirna content mps isol studi particip studi effect human pulmonari arteri smooth muscl hpasmc endotheli cell hpaec long term exposur cold environ associ enhanc pulmonari arteri pressur highland plasma level cde posit cd posit mps increas respons cold lowland haph highland mirna express contain mps differenti chang respons cold lowland highland mps isol lowland highland increas prolifer reduc apoptosi hpasmc mps isol warm expos haph highland cold expos highland exert pronounc effect vegf express hpaec demonstr prolong exposur cold associ elev pulmonari arteri pressur pronounc high altitud resid number circul mps differenti increas lowland haph highland colder season | D006976;D035683 | T046;T123;T114 |
36,230,893 | hmo protein affect nucleosom structur support nucleosom reorgan activ yeast fact yeast hmo high mobil group b hmgb protein particip transcript ribosom protein gene rdna also stimul activ atp depend remodel hmo bind dna nucleosom propos function yeast analog mammalian linker histon use emsa singl particl frster reson energi transfer spfret microscopi character effect hmo nucleosom alon histon chaperon fact hmo induc signific increas distanc dna gyre across nucleosom core also caus separ linker segment opposit effect linker histon h enhanc proxim linker similar nhp anoth hmgb factor hmo abl support larg scale atp independ revers unfold nucleosom fact spfret assay partial support fact function vivo howev unlik hmo nhp alon affect nucleosom structur result suggest physiolog role hmo distinct nhp possibl hmgb factor linker histon h | D009707;D029701 | T123;T116 |
36,230,892 | cytochrom p b key regul ocular iron homeostasi oxid stress cytochrom p cyp b belong superfamili heme contain monooxygenas unlik cyp enzym high express liver cypb predomin found extrahepat tissu brain ocular tissu includ retina trabecular meshwork cypb metabol exogen chemic polycycl aromat hydrocarbon cypb also metabol endogen bioactiv compound includ estradiol arachidon acid metabolit impact various cellular physiolog process develop patholog process previous show cypb defici mitig ischemia mediat retin neovascular drive trabecular meshwork dysgenesi increas level oxid stress howev under mechan respons cypb defici mediat increas oxid stress remain larg unresolv iron essenti element util cofactor varieti enzym howev excess iron promot product hydroxyl radic lipid peroxid increas oxid stress cell damag retin endothelium recogn major compon blood retin barrier control ocular iron level modul protein involv iron regul present retin endotheli cell well ocular cell type includ trabecular meshwork cell previous show increas level reactiv oxygen speci lipid peroxid absenc cypb retin vasculatur trabecular meshwork revers administr antioxid n acetylcystein review import role cypb express activ play maintain retin redox homeostasi modul iron level retin endotheli cell relationship cypb express activ iron level previous delin review potenti signific cypb express estrogen metabol hepcidin ferroportin regulatori axi local regul ocular iron level | D064451;D011084 | T109;T123;T116;T125 |
36,230,891 | molecular regul embryon diapaus cancer diapaus like state embryon diapaus enigmat state dormanc interrupt normal tight connect development stage time reproduct strategi state suspend develop occur mice bear roe deer mammal favor surviv newborn diapaus arrest embryo blastocyst stage delay post implant develop embryo month long quiescenc revers contrast senesc occur age stem cell recent studi reveal critic regul diapaus find import sinc defect diapaus state caus lack regener control normal growth control state may also therapeut applic sinc recent find suggest radiat chemotherapi may lead cancer cell protect diapaus like revers state interest recent studi shown metabol regul epigenet modif role microrna embryon diapaus review discuss molecular mechan diapaus induct | D003670;D000074767;D035683;D009369 | T191;T123;T040;T114;T015 |
36,229,945 | case report success revers residu block sugammadex patient known myasthenia gravi background incomplet recoveri residu neuromuscular block agent nmba anesthesia serious advers event post anesthesia care unit acetylcholinesteras neostigmin usual use revers residu neuromuscular blockad facilit spontan breath endotrach extub case report year old woman receiv general anesthesia strabismus correct surgeri end surgeri repeat dose neostigmin gkg fail revers residu neuromuscular blockad train four tof ratio sugammadex mg provid immedi revers tof ratio patient regain spontan breath endotrach tube remov surgeri myasthenia gravi diagnos conclus unexpect prolong neuromuscular blockad present tof ratio use detect depth guid reason dose revers agent anticholinesteras ceil effect acetylcholinesteras activ fulli inhibit administr addit anticholinesteras result recoveri furthermor excess acetylcholin caus muscl weak contrast sugammadex select revers agent steroid nmba work encapsul via tight water solubl complex amino steroid eg rocuronium rather increas acetylcholin neuromuscular junction case recoveri moder neuromuscular blockad sugammadex effect rapid neostigmin refractori prolong residu neuromuscular blockad present repeat dose anticholinesteras sugammadex consid effect revers agent particular case myasthenia gravi sugammadex superior neostigmin revers rocuronium induc nmba patient undergo surgeri | D055191;D009157;D003473;D047408 | T121;T047;T046;T109 |
36,229,939 | correl trough level abirateron prostat specif antigen psa respons metastat hormon sensit prostat cancer background prostat cancer growth primarili driven testosteron dihydrotestosteron abirateron irrevers inhibitor cyp cyp inhibit requir step testosteron biosynthesi previous studi shown abirateron trough level predict prostat specif antigen psa respons metastat castrat resist prostat cancer mcrpc demonstr associ exist patient metastat hormon sensit prostat cancer mhspc studi aim explor correl associ abirateron trough level psa level patient mhspc materi method singl center prospect observ studi patient mhspc treat abirateron acet aa mg daili abirateron trough level h drug administr drawn month treatment initi result thirteen patient mhspc enrol complet pharmacokinet data avail patient mean trough level month month month ngml ngml ngml respect correl month abirateron trough level month psa level p month abirateron trough month psa p month abirateron trough month psa p conclus studi demonstr trend toward negat correl month abirateron trough level psa level correl statist signific studi larger prospect sampl size need valid find | D017430;D064129 | T191;T126;T116;T129 |
36,229,918 | impact sodium nitroprussid concentr ad batch cultur escherichia coli biofilm c di gmp level morpholog adhes biofilm dispers cell biofilm dispers trigger applic dispers agent nitric oxid donor result releas biofilm dispers cell environ work biofilm dispers cell obtain ad differ concentr donor sodium nitroprussid mm snp batch cultur pre form escherichia coli biofilm except dispers snp biofilm dispers cell found wider longer plankton cell higher c di gmp level greater adhes forc silicon nitrid surfac water measur atom forc microscop consequ optimum concentr snp dispers e coli biofilm found snp whose addit batch cultur result signific biofilm dispers dispers cell c di gmp level morpholog adhes strength similar plankton counterpart | D018441;D004926 | T007 |
36,229,913 | long non code rna val facilit pkm enzymat activ promot glycolysi malign gastric cancer gastric cancer gc one common type cancer worldwid lead cancer relat death metabol reprogram present pivot event cancer initi progress enhanc aerob glycolysi anabol metabol howev under regulatori mechan gc remain unknown | D062085;D013274 | T191;T123;T114 |
36,229,912 | effect forest therapi psycholog improv middl age women korea women experi stress middl age period live therefor health manag program enabl middl age women cope manag stress need studi investig psycholog effect medit focus forest therapi program among middl age women live urban area korea | D065928;D011788 | T078;T070 |
36,229,911 | social contact pattern associ tuberculosi case control studi southwest iran tuberculosi tb major public health concern worldwid social contact pattern affect epidemiolog risk airborn diseas tb studi design investig social contact pattern associ tb | D014376 | T047 |
36,229,910 | associ metabol syndrom colorect cancer risk obes status korean women nationwid cohort studi studi aim determin associ metabol syndrom met incid colorect cancer crc korean women obes | D003110;D015179;D024821;D012004 | T191;T047 |
36,229,909 | korea cohort consortium futur pool cohort studi introduc cohort studi includ korea cohort consortium kcc focus larg scale cohort studi establish korea prolong follow period moreov also provid project follow estim sampl size would necessari big data analys base pool establish cohort studi includ popul base genom studi | D001943;D013274 | T191 |
36,229,908 | impact household econom deterior caus covid pandem socioeconom status suicid behavior adolesc cross section studi use korea youth risk behavior web base survey data econom hardship serious impact adolesc mental health financi impact coronavirus diseas covid pandem sever low incom famili also impact adolesc studi aim examin associ econom deterior ed caus covid pandem low socioeconom status ses adolesc suicid behavior | D000294;D000086382 | T055;T047;T067 |
36,229,907 | associ socioeconom status depress qualiti life patient hypertens analysi data communiti health survey korea aim identifi factor relat depress qualiti life patient hypertens use multilevel regress analysi | D006973;D011788 | T078;T047 |
36,229,906 | moder effect gender relationship self neglect suicid ideat older adult korea previous studi report self neglect may sign elder abus result suicid among older adult sign self neglect impact risk suicid may differ gender thus studi explor associ self neglect suicid risk older korean adult examin potenti moder effect gender relationship | D004552;D000077711;D013405 | T054;T048;T033 |
36,229,905 | knowledg attitud indonesian general practition toward isoniazid prevent therapi program indonesia indonesian ministri health launch isoniazid prevent therapi ipt general practition gps frontlin program howev extent gps intern program remain uncertain aim studi identifi knowledg attitud gps toward ipt program indonesia | D058005;D015658 | T047;T097 |
36,229,904 | statin intak gastric cancer risk updat subgroup meta analysi consid immort time bias retrospect record linkag studi rls base medic record contain drug prescript histori involv immort time bias itb thus necessari control bias research plan analysi stage furthermor summari metaanalysi includ rlss control itb show specif drug prevent effect occurr diseas previous meta analyt result three systemat review evalu associ statin intak gastric cancer risk show summari hazard ratio shr rlss lower statist signific consid possibl itb shr rlss interpret result care | D019161;D013274 | T121;T109;T191 |
36,229,903 | primari process key concept econom evalu healthcar econom evalu healthcar use assess econom effici pharmaceut medic intervent diagnos medic procedur studi introduc main concept econom evalu across key step plan outcom cost calcul model cost effect result uncertainti analysi decis make plan econom evalu determin studi popul intervent compar perspect time horizon discount rate type econom evalu healthcar econom evalu outcom includ chang mortal surviv rate life year qualiti adjust life year cost includ medic non medic product cost model base econom evalu includ decis tree markov model main use calcul total cost total effect cost effect costutil analys cost effect evalu use increment cost effect ratio addit cost per one addit unit effect gain intervent compar compar outcom uncertainti owe limit evid divers methodolog unexplain variat thus research review uncertainti confirm robust hope contribut establish dissemin econom evalu methodolog reflect korean clinic research environ ultim improv ration healthcar polici | D003695 | T093;T058 |
36,229,898 | determin barbitur femtosecond ionize mass spectrometri barbitur high suscept dissoci mass spectrometri ms long side chain combin nonaromat ring consist sever carbonyl amin group result exhibit extens cleavag subsequ rearrang make identif compound difficult although librari electron ionize ms eim avail barbitur similar fragment pattern accord would desir develop techniqu soft ionize provid molecular ion larg fragment ion well studi molecular ion clear observ addit larg fragment ion varieti barbitur base multiphoton ionize ms mpim use tunabl ultraviolet femtosecond laser ionize sourc fs lim favor result achiev optim laser wavelength minim excess energi remain ionic state use examin photofragment pathway suggest h atom side chain abstract oxygen atom carbonyl group ring structur thus initi fragment subsequ rearrang barbitur substitut alkyl group amobarbit pentobarbit narrow spectral region optim ionize barbitur alkyl alkenyl group butalbit secobarbit alkyl phenyl group phenobarbit barbitur studi provid uniqu mass spectral pattern fs lim use reliabl identif compound practic trace analysi | D012631;D000654 | T121;T109 |
36,229,897 | macrophag deriv extracellular vesicl regul follicular activ improv ovarian function old mice modul local environ mammal ovarian function depend primordi follicl pool rate primordi follicl activ determin femal reproduct lifespan ovarian age characteris chronic low grade inflamm acceler deplet primordi follicl deterior oocyt qualiti macrophag ms play critic role multipl aspect ovarian function howev remain unclear whether ms modul primordi follicl pool role ovarian age use super natur ovul mous model demonstr first time ovul induc local inflamm act driver select activ surround primordi follicl estrous cycl find relat infiltr ms ovulatori follicl dynam chang two polaris ms ms process studi newborn ovari cocultur differ subtyp ms demonstr stimulatori effect ms primordi follicl wherea ms maintain follicl dormant state under mechan associ differenti regul phosphatidylinositol kinasemechanist target rapamycin pikmtor signal pathway secret extracellular vesicl ev contain specif mirna mir ms mir p ms age mice intraven inject ev improv ovarian function amelior inflammatori microenviron within ovari thus base anti age effect ms old mice ev may repres new approach improv inflamm relat infertil women | D000067128;D035683 | T026;T123;T114 |
36,229,894 | water lipid content breast tissu measur six wavelength time domain diffus optic spectroscopi significanceth water lipid content normal breast tissu show mammari gland characterist less influenc chest wall use six wavelength time domain diffus optic spectroscopi td dos reflect geometryaimto determin depth sensit six wavelength td dos system evalu whether optic paramet normal breast tissu distinguish dens breast non dens breastsapproachmeasur perform normal breast tissu breast cancer patient employ six wavelength td dos system measur water lipid content addit hemoglobin concentr breast densiti mammographi optic paramet comparedresultsth depth sensit system water lipid content estim mm find suggest influenc chest wall water content weaker total hemoglobin concentr data evalu condit water content signific higher p lipid content signific lower p dens breast tissu water lipid content exhibit high sensit specif distinguish dens non dens breast receiv oper characterist curv analysisconclusionswith less influenc chest wall water lipid content normal breast tissu measur reflect six wavelength td dos system togeth ultrasonographi appli distinguish dens non dens breast | D001943;D014867 | T191;T197;T121 |
36,226,044 | general hypothesi multist system pathophysiolog despit intens investig numer diseas remain etiolog puzzl recalcitr treatment hypothesi propos assum difficulti due unsuit approach mechan life subjug appar complex fail grasp uniform lay behind stabil metabol despit enorm complex chemic reaction suggest reciproc control prerequisit life negat feedback loop known long time maintain homeostasi recent differ life process involv transit chang model posit loop give rise bistabl switch also includ various diseas present hypothesi make general assum function element biolog system involv posit negat feedback loop consequ hypothesi hold start mechan diseas affect healthi human conceptu reduc bistabl multistationari loop system thus provid unifi model lead discoveri critic therapeut target | D006706 | T038 |
36,226,043 | parent percept polici earli childhood care educ programm select state malaysia agenda sustain develop propos global equit qualiti educ lifelong learn opportun children qualiti earli childhood care educ ecc program help shape children mind attitud behavior short long term effect child famili countri malaysia govern formul polici law protect children right howev ecc face challeng purpos studi investig parent percept qualiti ecc program implement malaysian govern | D005190;D010290 | T054;T099;T102;T062;T079 |
36,226,038 | arizona sexual experi scale thai translat asex thai reliabl valid thai patient mental disord background sexual dysfunct common among patient mental disord receiv less clinic attent especi thailand asian countri arizona sexual experi scale thai translat asex thai self rate brief questionnair potenti tool screen sexual dysfunct popul studi aim assess reliabl valid asex thai thai patient mental disord method enrol patient outpati psychiatr depart tertiari hospit bangkok thailand demograph data clinic data diagnosi sexual dysfunct assess asex thai done analyz test psychometr properti result particip diagnos major depress disord posit correl asex thai sexual dysfunct diagnosi r p kmo coeffici barlett spheric test signific p score point asex thai suitabl sexual dysfunct screen sensit specif reliabl cronbach alpha coeffici show good intern consist conclus asex thai valid reliabl self rate questionnair screen sexual dysfunct among thai patient mental disord test could help clinician evalu undetect condit deliv proper intervent | D003865;D001523;D012735 | T046;T048 |
36,111,218 | case report interstiti intralesion laser therapi laser assist new attach procedur treatment alveolar bone loss provok aggress pyogen granuloma background pyogen granuloma pg common benign vascular lesion found oral caviti gold standard treatment lesion compris surgic excis elimin etiolog factor avoid tooth loss case aggress pyogen granuloma promin properti nm nm diod laser photocoagul photobiomodul appli wavelength treatment larg pyogen granuloma alveolar bone loss case present object use combin interstiti intralesion laser therapi photocoagul laser assist new attach procedur lanap preserv teeth periodont tissu case aggress pyogen granuloma result patient year old thai male pyogen granuloma involv interdent papilla lingual gingiva lower left first second molar teeth also displac lesion treatment three session photocoagul three session interstiti intralesion laser therapi two session lanap lesion complet resolv periodont status teeth improv six month follow conclus combin interstiti intralesion laser therapi photocoagul lanap abl treat aggress pyogen granuloma tooth preserv | D016301;D017789;D053685 | T191;T061;T047;T074 |
36,229,887 | absenc epstein barr virus dna anti citrullin protein antibodi express b cell patient rheumatoid arthriti rheumatoid arthriti ra character presenc diseas specif autoreact b cell respons particular generat anti citrullin protein antibodi acpa mani year epstein barr virus ebv implic diseas pathogenesi possibl facilit develop persist autoreact b cell test hypothesi presenc ebv episom acpa express b cell analyz | D001172;D020031 | T047 |
36,229,886 | mendelian gene identif mous embryo viabil screen diagnost rate mendelian disord sequenc studi continu increas along pace novel diseas gene discoveri howev variant interpret novel gene current associ diseas particular challeng strategi combin gene function evid approach evalu phenotyp similar patient model organ proven success full spectrum intoler loss function variat previous describ provid evid gene essenti consid simpl fix binari properti | D004622;D005804 | T018;T028 |
36,229,885 | clinic characterist sitosterolem children xanthoma first manifest sitosterolemia stsl extrem rare genet diseas xanthoma first symptom frequent misinterpret famili hypercholesterolemia fh children inappropri treatment may deterior condit stsl | D006937;D006938;D014973 | T047 |
36,229,884 | pulmonari papillari adenoma malign potenti case report literatur review pulmonari papillari adenoma rare benign tumor peripheri lung report year old femal patient tumor lower lobe right lung present clinicopatholog featur review literatur | D000236;D008175 | T191 |
36,229,882 | effect sphingolipid metabol disord endotheli cell mani cardiovascular disord includ atherosclerosi hypertens coronari heart diseas diabet etc character endotheli cell dysfunct endotheli cell function close relat sphingolipid metabol normal sphingolipid metabol critic maintain endotheli cell homeostasi sphingolipid metabolit key enzym abnorm situat includ sphingosin ceramid cer sphingosin phosphat sp serin sphingosin kinas sphk ceramid kinas cerk sphingosin phosphat lyas spl etc may protect damag effect function endotheli cell review summar effect sphingolipid metabolit key enzym disord sphingolipid metabol endotheli cell offer insight research pathogenesi cardiovascular diseas correspond therapeut target | D013107;D013110 | T109;T123 |
36,229,880 | manag initi surgeri nonfunct pituitari adenoma surveil radiotherapi surgeri first line treatment nonfunct pituitari adenoma nfpa surgeri adjuv radiotherapi surveil new treatment second surgic oper salvag radiotherapi case recurr option discuss multidisciplinari tumor board purpos studi evalu therapeut outcom option | D000236;D008577;D008579;D010911 | T191 |
36,229,877 | virul phenotyp genotyp characterist invas group b streptococcus isol obtain swedish pregnant women neonat group b streptococci gbs bacteria caus preterm birth invas neonat diseas heterogen express virul factor enabl gbs exist commens bacteria becom high invas molecular epidemiolog studi compar gbs bacteri trait genotyp host characterist may indic whether possibl predict risk perinat invas gbs diseas accur target intrapartum antibiot prophylaxi total invas gbs isol swedish pregnant women neonat assess virul phenotyp trait hemolysi zone hemolyt pigment granada agar streptococcus b carrot broth sbcb assay camp factor hyaluronidas activ gene regul hemolyt pigment synthesi covrcov abx stk stp sequenc virul factor phenotyp assess granada pigment sbcb score captur eod isol excel inter rater reliabl high enzym activ hyaluronidas observ invas gbs isol notabl one case stillbirth hyaluronidas activ also signific higher gbs isol obtain pregnantpostpartum individu versus stillbirth neonat invas isol p sequenc analysi found abx gti stk gtn stp gkr cov gvm variant present signific often higher granada pigment score versus lower pigment isol p variant among higher granada pigment score isol isol four sequenc variant four sequenc variant although heterogen gbs virul factor express observ vast major high pigment contain sever common sequenc variant gene regul pigment synthesi high activ hyaluronidas may increas risk stillbirth invas diseas pregnant postpartum individu find suggest test gbs pigment hyaluronidas may albeit imperfect identifi pregnant peopl risk invas diseas repres step toward person medic approach administr intrapartum antibiot prophylaxi | D047928;D013290 | T047;T046 |
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