PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,225,533 | hypercapnia physiolog practic acut hypercapn ventilatori failur becom frequent critic ill patient hypercapnia elev partial pressur carbon dioxid paco mmhg bloodstream pathophysiolog mechan hypercapnia includ decreas minut volum increas dead space increas carbon dioxid co product per sec generat compromis cardiovascular cerebr metabol respiratori level high burden morbid mortal essenti know trigger provid therapi direct primari caus avoid possibl complic | D002245;D006935 | T123;T197;T033 |
36,225,392 | join forc basic scienc meet second intern transplant scienc meet joint organ european societi organ transplant esot american societi transplant ast transplant societi tts took place may one europ icon citi berlin germani meet design serv intern platform scientif discuss latest ground break discoveri field provid excel opportun present cut edg research scientif communiti think fundament exchang new idea establish collabor work advanc transplant expert young profession earli stage research student scientif session tackl hot topic transplant mechan toler biomark big data artifici intellig educ pre meet focus breakthrough challeng singl cell multimod omic program includ panel discuss illumin various topic concern conflict problem relat gender challeng femal scientist attende return institut profound knowledg latest discoveri technolog concept basic translat scienc also inspir excit discuss network session fellow scientist duli miss pandem | D016377;D019737 | T061;T025;T024;T023 |
36,225,387 | relationship speech intellig fluenci indic among english speak individu parkinson diseas purpos studi investig much varianc parkinson diseas pd individu speech intellig could predict seven speech fluenci indic ie repetit omiss distort correct unfil paus fill paus speak rate speech data retriev databas contain read task produc group english speak individu pd jaeger trivedi stadtchnitz result multipl regress indic addit varianc speech intellig score among individu pd could account speaker pd sever level measur base hoehn yahr diseas stage includ covari addit omiss correct two fluenci indic contribut general intellig score statist signific way specif everi one unit gain number correct omiss speech intellig score would declin point point scale respect current studi henc support mage copland vogel view languag product abil quantifi dysarthria measur among individu pd explor togeth addit clinic implic base current find discuss | D010300;D013065 | T047;T080 |
36,225,235 | understand etiolog communiti acquir central nervous system infect use metagenom next generat sequenc communiti acquir central nervous system infect ca cns infect characterist acut onset rapid progress associ high level morbid mortal worldwid howev limit studi etiolog infect metagenom next generat sequenc mngs comprehens diagnosi method facilit us better understand etiolog ca cns infect | D002494;D020031 | T047 |
36,225,233 | risk factor hospit mortal patient pneumocysti pneumonia diagnos metagenom next generat sequenc metagenom next generat sequenc mngs test use rapid accur detect identif pathogen microorgan aim present studi investig factor associ hospit mortal pneumocysti pneumonia pcp patient mngs assist diagnosi | D011020 | T047 |
36,225,232 | clinic valid visual lamp qlamp assay rapid detect toxoplasma gondii human expos toxoplasma gondii infect pet cat gradual becom famili member repres increas public health risk worldwid toxoplasmosi diagnosi constitut import measur diseas prevent control studi real time fluoresc quantit loop mediat isotherm amplif qlamp visual lamp detect technolog establish conduct test gondii base membran dna extract method optim detect mix determin ad protect reagent trehalos screen concentr mg dntps paraffin lyophil use reduc even remov aerosol pollut construct detail anti contamin protocol base posit standard plasmid dna lod qlamp visual lamp copiesl copiesl standard curv qlamp yx r applic qlamp visual lamp assay diseas diagnosi assess evalu clinic cat faec sampl assay show good diagnost consist kappa valu compar taq man qpcr respect compar taq man qpcr diagnost specificitysensit qlamp visual lamp respect qlamp visual lamp assay report rapid simpl test without extens sampl prepar short turnaround time within min make suitabl point care test | D014122;D014123 | T047;T204 |
36,225,231 | non capsular base immun approach prevent streptococcus pneumonia infect streptococcus pneumonia gram posit bacterium lead caus bacteri pneumonia children elder worldwid current two type licens vaccin avail prevent diseas caus pathogen valent pneumococc polysaccharid base vaccin valent pneumococc conjug vaccin howev vaccin compos princip capsular polysaccharid lead serotyp bacterium problem high product cost serotyp depend effect drawback stimul research initi non capsular base vaccin search univers vaccin pneumonia last decad sever research group develop various new vaccin bacterium base recombin protein live attenu bacterium inactiv whole cell vaccin newer platform review discuss status non capsular vaccin pneumonia futur altern post pandem scenario | D011008 | T047 |
36,225,230 | il rb receptor il signal pathway regul host defens oral mucos candidiasi pseudomembran candidiasi thrush erythemat candidiasi fungal esophag infect barrier mucosa upper gastrointestin tract major infect caus candida albican opportunist fungal pathogen frequent exist harmless commens mucos surfac line gastrointestin tract oral infect initi superfici stratifi squamous epithelium keratinocyt abund host cell initi point contact c albican present saliva intrins featur oral keratinocyt like play import role host defens tissu homeostasi oral candidiasi one understudi pathway may import modul oral candidiasi il cytokin signal pathway employ keratinocyt il rb receptor ligand il il il report product human oral keratinocyt il mrna protein stimul co cultur c albican test role il famili signal pathway oral candidiasi ilrb mice lack il rb receptor compar wild type mice murin model oropharyng candidiasi fungal burden percent loss bodi weight determin despit compar fungal burden ilrb mice exhibit less weight loss cours infect compar b mice suggest reduc overal diseas consequ mutant mice interfer il famili cytokin signal may use augment abil host defend pathogen | D002177;D002180 | T047 |
36,225,208 | daili requir softgel thyroxin independ gastric juic ph softgel levothyroxin lt prepar show better vitro dissolut profil increas ph compar tablet lt prepar clinic studi suggest better perform softgel lt prepar patient gastric disord whether find relat gastric juic ph variat vivo known | D013972;D013974 | T121;T109;T116;T125 |
36,225,207 | tendenc wors cours multisystem inflammatori syndrom children obes multiorgan inflammatori syndrom covid relat studi new diseas entiti call multisystem inflammatori syndrom children mis c rare consequ covid infect pathophysiolog risk factor mis c still unclear clinic manifest rang milder form case need intens care unit treatment base avail data obes link pro inflammatori stimul moreov sever studi show obes could play role covid sever comorbid among adult children popul studi aim investig influenc overweightednessobes childhood cours mis c poland | D000086382;D063766 | T047;T067;T033 |
36,225,206 | genet overlap osteoporosi craniosynostosi osteoporosi preval bone condit age popul system diseas character microarchitectur deterior bone lead increas fractur risk past year genom wide associ studi gwas pinpoint hundr loci associ bone miner densiti bmd help elucid under molecular mechan genet architectur fractur risk howev challeng remain pinpoint causat gene drive gwas signal pivot step draw translat therapeut roadmap recent skull bmd gwas uncov intrigu intersect craniosynostosi congenit anomali due prematur sutur fusion skull recapitul genet contribut osteoporosi craniosynostosi describ biolog underpin overlap use zebrafish model leverag function investig gene associ skull develop system skelet homeostasi | D003398;D010024 | T047;T019 |
36,225,205 | treatment omega pufa increas risk cype depend oxid stress diabet liver patholog increas cype express key factor develop diabet oxid liver damag long term treatment omega pufa cype substrat may affect cype express liver work perform western blot analysi biochem method microscop ultrastructur studi liver streptozotocin induc rat model type diabet investig whether long term treatment omega pufa could induc cype depend oxid stress diabet liver patholog signific hyperglycemia lack natur weight gain observ diabet rat compar non diabet control fold increas cype express protein content activ also observ diabet rat addit sign oxid stress found liver diabet rat signific increas transaminas ggt level blood serum also observ could indic mark destruct liver tissu diabet dyslipidemia increas triacylglycerol level decreas hdl c level found treatment diabet anim omega enrich pharmaceut composit pufa effect cype level contribut two fold decreas enzym activ intens lipid peroxid also remain close diabet group howev time antioxid protect provid induct antioxid enzym activ examin liver ultrastructur reveal characterist sign diabet patholog howev omega pufa normal blood glucos level serum lipid profil thus long term treatment diabet rat omega pufa increas risk cype depend oxid stress develop liver patholog prevent diabet ultrastructur damag hepatocyt | D003921;D015525 | T121;T050;T109;T123 |
36,225,203 | safeti sotagliflozin therapi diabet mellitus type type meta analysi random trial diabet mellitus dm global health problem becom shock threat contemporari era object studi analyz safeti sotagliflozin patient dm systemat intuit | D003922;D003924;D016883;D007003 | T047 |
36,225,202 | effect yushen hezhi therapi postmenopaus osteoporosi overview systemat review random control trial review systemat review srs meta analys mas yushen hezhi therapi yshzt postmenopaus osteoporosi pmop provid evid base recommend research decis maker | D015663 | T047 |
36,225,201 | skelet outcom patient osteogenesi imperfecta drug holiday bisphosphon real world studi studi aim investig skelet outcom patient osteogenesi imperfecta oi receiv bisphosphon bp treatment enter drug holiday achiev age sex specif bone miner densiti bmd refer | D050723;D010013 | T047;T037 |
36,225,200 | role irisin physiolog patholog irisin membran part fibronectin type iii domain contain protein fndc activ peroxisom prolifer activ receptor ppar coactiv pgc physic exercis skelet muscl tissu studi report concentr irisin high associ health status instanc level irisin signific lower patient obes osteoporosisfractur muscl atrophi alzheim diseas cardiovascular diseas cvds higher patient cancer irisin bind receptor integrin v induc brown white fat maintain glucos stabil keep bone homeostasi allevi cardiac injuri howev unclear whether work direct bind receptor regul muscl regener promot neurogenesi keep liver glucos homeostasi inhibit cancer develop supplement recombin irisin exercis activ irisin might success strategi fight obes osteoporosi muscl atrophi liver injuri cvds one go summar public fndcirisin pubmedmedlin scopus web scienc march review role fndcirisin physiolog patholog | D005353;D010024 | T047;T123;T116 |
36,225,198 | rosiglitazon allevi contrast induc acut kidney injuri rat via ppar nlrp signal pathway studi investig effect mechan rosiglitazon rat model contrast induc acut kidney injuri ci aki | D058186;D000077154 | T121;T047;T109;T037 |
36,225,197 | applic cytochrom c relat gene prognosi treatment predict lung adenocarcinoma lung adenocarcinoma luad common subtyp nonsmal cell lung cancer cytochrom c cyt c produc mitochondria interact protein call apaf form heptamer apoptosom heptamer apoptosom activ caspas cascad ultim result execut apoptosi purpos research discov new prognost model base cytochrom c relat gene ccrgs luad patient lasso regress analysi conduct luad dataset includ tcga dataset ccrgs signatur creat diagnost accuraci multigen signatur verifi independ sourc use gse gse dataset go kegg enrich analysi perform studi differenti express ccrgs tcga dataset differenti express ccrgs gse dataset addit gene overlap across two dataset use lasso cox regress analysi signatur consist differenti express ccrgs develop total gene basi risk rate patient categor high risk low risk categori low risk patient lower risk score greater likelihood surviv diseas univari multivari analys conclud signatur independ risk factor luad roc curv demonstr risk signatur capabl accur predict year year year year surviv rate patient luad infiltr antigen present cell higher low risk group adc dcs pdcs idc express multipl immun checkpoint signific higher low risk group btla cd cd final show signatur use predict drug sensit alreadi avail investig drug overal patient classif individu therapi option may benefit studi develop power gene signatur high valu prognost predict luad | D000077192;D002289;D008175 | T191 |
36,225,196 | clinicopatholog signific stat p stat among patient adenocarcinoma esophagogastr junction adenocarcinoma esophagogastr junction aeg increas rapid worldwid last decad purpos studi investig clinic prognost characterist signal transduct activ transcript factor stat phosphoryl stat p stat express aeg patient retrospect analyz immunohistochem result aeg patient follow year western blot perform tissu anoth aeg patient result show stat p stat overexpress aeg tissu p p high express stat signific associ ptnm stage p increas express p stat signific associ depth invas pt lymph node metastasi pn ptnm stage p p p year surviv rate aeg patient signific associ tumor differenti pn ptnm p stat p p p p cox regress analysi confirm tumor differenti pn high express p stat independ risk factor year surviv rate patient aeg p p p studi show stat p stat play critic role aeg develop | D000230;D004938;D013274 | T191 |
36,225,195 | senkyunolid h affect cerebr ischem injuri regul autophagi neuron cell via pkaktmtor signal pathway cerebr ischemia ci associ high global incid risk therefor rapid reliabl therapeut manag essenti protect patient live improv health senkyunolid h sh remark effect phlebosclerosi oxid apoptosi blood brain barrier main obstacl imped deliveri drug xenobiot brain area drug load nanoparticl overcom blood brain barrier obstacl thus direct complet act brain tissu load also chang half life drug vivo lower dosag requir drug studi load sh lipid nanoparticl improv deliveri brain therapi ci thus studi preliminarili analyz mechan sh load nanoparticl ci sh load lipid nanoparticl prepar character electron microscopi ps potentiometeri sh load nanoparticl intraperiton administ ci induc rat brain tissu water content neuron apoptosi autophagi associ protein determin assay reveal sh load nanoparticl abil reduc nerv injuri brain tissu water content rat ci inhibit apoptosi autophagi neuron cell ncs addit intervent sh load nanoparticl pkaktmtor pathway associ protein brain tissu rat decreas assay result show sh load nanoparticl suppress autophagi ncs medic pkaktmtor pathway lower apoptosi thus deliv effect treat ci result studi indic sh load nanoparticl promis strategi deliveri sh brain area treat ci | D001930;D002545 | T047;T046;T037 |
36,225,179 | identif oxid stress associ molecular subtyp signatur predict surviv outcom cervic squamous cell carcinoma cervic squamous cell carcinoma cesc gynecolog malign high incid rate high mortal rate oxid stress particip gene regul malign tumor progress includ cesc | D001859;D001943;D002294;D002583 | T191 |
36,225,178 | effect mir p inhibit serum uromodulin amelior myocardi inflamm apoptosi induc ischemia reperfus found mir p close relat cardiovascular metabol risk factor nonetheless littl research analyz mir p role well molecular mechan myocardi injuri caus ischemia reperfus ir | D035683;D009205 | T047;T123;T114 |
36,225,177 | express eif gene glioma sensit oxid stress increas express eif observ various cancer make eif attract target anticanc drug studi main discuss eif gene express glioma sensit oxid stress os | D005910;D006861 | T191;T130;T197;T121 |
36,225,176 | endogen vasoact peptid vascular age relat diseas vascular age specif type organ age play central role morbid mortal cardiovascular cerebrovascular diseas among elder essenti develop novel intervent preventdelay age relat vascular patholog target fundament cellular molecular age process endogen vasoact peptid compound form group amino acid connect peptid chain exert regulatori role intercellular interact involv varieti biolog patholog process emerg evid suggest varieti vasoact peptid play import role occurr develop vascular age relat diseas atherosclerosi hypertens vascular calcif abdomin aortic aneurysm stroke review summar cumul role mechan sever import endogen vasoact peptid vascular age vascular age relat diseas addit also aim explor promis diagnost function biomark potenti therapeut applic endogen vasoact peptid vascular age relat diseas | D050197;D014652 | T047;T046 |
36,225,175 | nfgf protect cell high glucos induc apoptosi via ampksirtpgc axi long term exposur high glucos lead cell dysfunct death fibroblast growth factor fgf emerg promis diabet treatment pharmaceut role mechan glucolipotox induc cell dysfunct remain uncharacter wild type fgf fgf wt may exhibit vivo mitogen delet n termin residu give nonmitogen variant nfgf promot cell prolifer still retain metabol activ fgf wt investig role nfgf glucos regul potenti islet cell dysfunct db db mice use model type diabet result show insulin secret apoptosi islet cell dramat improv nfgf treat db db mice test effect nfgf treatment pancreat cell min cell expos mixtur palmit acid pa high glucos hg mimic glucolipotox condit vitro treatment nfgf signific inhibit glucolipotox induc apoptosi mechanist nfgf exert protect effect cell via activ ampksirtpgc signal pathway find demonstr nfgf protect pancreat cell glucolipotox induc dysfunct apoptosi | D003924;D050417 | T047;T025 |
36,225,174 | macrophag deriv exosom tlr mice amelior sepsi induc mitochondri oxid stress apoptosi cardiomyocyt explor mechan tlr macrophag mitochondri apoptosi cardiomyocyt earli stage sepsi | D055354;D018805 | T026;T046;T047 |
36,225,173 | comparison antiosteoporot effect cornelian cherri cornus mas l extract red yellow fruit contain differ constitu polyphenol iridoid osteoblast osteoclast polyphenol iridoid constitu extract analyz qualit quantit use ultraperform liquid chromatographi system coupl quadrupol time flight mass spectrometri primari cultur osteoblast isol mous calvaria osteoclast lineag primari cultur monocyt isol mous bone marrow use assess osteoblast osteoclast differenti osteoblast cultur cellular viabil alkalin phosphatas alp activ alp stain mrna express alpl runx examin osteoclast cultur examin paramet cellular viabil tartrat resist acid phosphatas trap activ stain mrna express nfatc ctsk acp | D029768 | T002 |
36,225,172 | pathogenesi diagnost signific ebv mir bart nasopharyng carcinoma examin role ebv mir bart nasopharyng cancer etiolog diagnosi | D035683;D009303 | T191;T123;T114 |
36,225,170 | labstogorecip build chromatographi equip includ biolog assay effect detect complet recip build chromatographi equip readili avail materi introduc combin sampl separ chemistri laboratori biolog effect detect biolog laboratori hyphen two disciplin necessari priorit import compound complex sampl among thousand compound therein often clear compound import one separ surfac addit detect biolog effect enabl guid substanc priorit newli develop open sourc labstogo system chemic biolog analysi complet solvent resist due miniatur environment friend regard consumpt materi produc compar result time compact cm cm cm time lighter kg time less expens current sophist commerci devic proof concept first labstogo system qualiti differ water sampl analyz sinc clean water becom increas rare water thousand substanc signal featur neither identifi classifi toxicolog howev method exploit hyphen strategi provid answer essenti safeti issu drink tap water show bioactiv toxic compound expect wherea bioga landfil water sampl hyphen labstogo strategi afford extrem use laboratori limit equip press challeng readi use various analyt task applic | D056804;D002845 | T059;T109 |
36,225,159 | prep awar protect barrier negoti among transgend peopl attract men aotearoa new zealand intern tran women disproportion impact hiv encount specif barrier navig safer sex face inequ access hiv prevent includ pre exposur prophylaxi prep aotearoanew zealand hereaft aotearoa one first countri intern public fund prep includ tran peopl howev data exist prep awar sexual negoti among tran popul guid implement present first aotearoa data tran peopl abil negoti barrier protect awar prep efficaci avail | D015658;D065129;D000072339;D063106 | T098;T061;T047 |
36,225,155 | reach transgend popul zambia hiv prevent linkag treatment use communiti base servic deliveri transgend gender divers communiti zambia high vulner experi healthcar differ cisgend person univers maryland baltimor umb support project zambia improv hiv case find linkag antiretrovir treatment art zambia transgend communiti describ programm strategi outcom hiv prevent test art linkag among transgend communiti | D015658;D065129;D063106 | T098;T061;T047 |
36,225,154 | sexual happi satisfact sexual safeti among german tran men sex men result emi popul men sex men msm includ peopl masculin spectrum assign femal birth afab tran msm studi aim identifi current circumst regard sexual happi safeti among german tran msm date health inform tran msm germani limit abil msm sexual health programm meet need | D015658;D000072339 | T098;T047 |
36,225,153 | evalu nine cultur tailor intervent design enhanc engag hiv care among transgend women colour unit state transgend women tw worldwid high preval hiv tw hiv encount numer healthcar barrier critic develop evid inform intervent improv engag healthcar achiev durabl viral suppress vs evalu whether particip one nine intervent design specif tw associ improv engag hiv care among transgend women colour twc | D015658;D063106 | T098;T047 |
36,225,152 | hiv test among transgend nonbinari person michigan unit state result communiti base survey transgend tran nonbinari peopl tnb disproportion impact hiv hiv test critic engag tnb peopl hiv prevent care yet scant literatur examin social structur factor associ hiv test among tnb peopl divers gender geographi potenti lower tran accept character preval never test hiv identifi associ factor among tnb peopl michigan unit state | D015658;D063106 | T098;T047 |
36,225,151 | review ankl rehabilit devic treatment equinus contractur equinus contractur serious disabl attent paid proper effect treatment attent given neurolog impair patient incid equinus contractur much higher exampl post traumat patient addit convent physic therapi robot rehabilit treatment one promis procedur preced sever contract case need surgeri | D004863;D019637 | T061;T190;T019 |
36,225,148 | factor associ long term hiv pre exposur prophylaxi engag adher among transgend women brazil mexico peru result imprep studi hiv epidem continu disproportion impact latin american transgend women tgw assess factor associ long term pre exposur prophylaxi prep engag adher among tgw enrol implement prep imprep studi largest prep demonstr studi latin america | D019380;D015658;D065129;D012749;D063106 | T121;T061;T047;T098 |
36,225,147 | differenti hiv servic transgend peopl four south african district popul characterist hiv care cascad transgend peopl south africa disproportion affect hiv discrimin stigma access healthcar health outcom poor although integr gender affirm healthcar differenti hiv prevent care treatment servic shown improv hiv servic uptak health outcom among transgend peopl evid lack implement differenti servic deliveri model southern africa articl describ differenti servic deliveri model across four south african site transgend individu access servic assess whether hormon therapi ht associ continu use pre exposur prophylaxi prep viral load suppress | D015658;D065129;D063106 | T098;T061;T047 |
36,225,145 | hiv preval among transmasculin individu new york citi communiti health centr cross section studi multipl studi demonstr elev incid preval hiv among transgend women howev studi conduct among transmasculin individu hiv preval among transgend men unit state estim howev us studi examin hiv preval stratifi gender sexual partner aim research examin hiv preval associ socio demograph factor includ gender sexual partner receipt gender affirm care hormonessurgeri among transmasculin individu callen lord communiti health center new york citi | D015658;D063106 | T098;T047 |
36,225,140 | hiv awar prevent strategi among transgend women eastern southern unit state find lite studi transgend women tw experi increas risk human immunodefici virus hiv acquisit studi identifi pattern hiv awar prevent strategi use tw live hiv | D015658;D065129;D000072339;D063106 | T098;T061;T047 |
36,225,139 | model cervic cancer elimin use singl visit screen treatment strategi context high hiv preval estim kwazulu natal south africa set high hiv preval cervic cancer incid rate six fold higher global averag case per women year inform strategi global cervic cancer elimin use dynam transmiss model evalu scalabl screen treatment strategi account hiv associ cancer risk weigh prevent gain overtreat | D015658;D030361;D002583 | T191;T047 |
36,225,136 | world health organ work recommend improv health tran gender divers peopl world health organ guid global programm work goal billion peopl univers health coverag uhc achiev uhc access vulner must guarante priorit commit develop evid base guidanc work toward uhc tran gender divers tgd peopl commentari describ work relat tgd peopl last decad | D015658;D000072339;D012749;D063106 | T098;T047 |
36,225,134 | ethic hiv research transgend non binari communiti unit state transgend individu experi disproportion high rate hiv infect popul increas focus epidemiolog implement scienc research combat epidem howev studi particip provid advoc becom increas concern research practic may alien objectifi exploit even traumat communiti design benefit commentari explor common pitfal hiv research transgend communiti provid potenti framework ethic communiti engag research practic | D015658;D063106 | T098;T047 |
36,225,133 | care whole person transgend compet hiv pre exposur prophylaxi part integr primari healthcar servic vietnam although hiv preval among transgend women sex men vietnam high uptak pre exposur prophylaxi prep low compar popul prep initi gender affirm healthcar larg unavail lack access compet stigma free healthcar well document barrier transgend women uptak prep primari healthcar phc aim demonstr util prep qualiti improv intervent pinpoint address barrier prep use among transgend women vietnam | D019380;D015658;D065129;D063106 | T121;T061;T047;T098 |
36,225,125 | nt interven examin role guardianship prevent institut child sexual abus recent year fail institut safeguard children sexual abus brought light investig commiss inquiri australia royal commiss institut respons child sexual abus role adult guardian protect children within institut afford particular scrutini highlight past ineffect harm intervent respons abus even inact despit attent limit research date explor barrier underpin guardianship behavior set enhanc understand potenti barrier guardianship key inform improv guardianship behavior futur use data australia royal commiss studi appli reynald model capabl guardianship investig dimens guardianship youth serv institut set three discret set examin outsid school hour care school sport institut result support util reynald model advanc knowledg guardianship behavior youth serv institut provid valuabl lesson futur polici direct enhanc safeguard practic | D002650 | T048 |
36,225,119 | variat volatil compound raw pu erh tea upon steep process gas chromatographi ion mobil spectrometri character aroma activ compound tea infus use gas chromatographi olfactometri mass spectrometri steep process import factor aroma releas tea rare investig aroma chang raw pu erh tea rapt addit comprehens aroma characterist identif rapt infus necessari studi gc im coupl princip compon analysi pca use clarifi differ volatil profil steep process rapt furthermor volatil contain rapt infus extract three pretreat method hs spme sbse safe identifi use gc ms accord odor activ valu compound categor aroma activ compound aroma recombin omiss experi show fatti green fruiti floral consid main aroma attribut rapt infus strong relationship octen one octen ol e octen ionon linalool etc studi contribut better understand mechan rapt steep process volatil generat | D013662;D055549 | T109;T168 |
36,225,106 | urgenc bowel movement high discriminatori symptom activ diseas person ibd manitoba live ibd studi inflammatori bowel diseas symptom inventori ibdsi valid patient self report measur use assess ibd diseas activ yet granular analys symptom associ activ diseas | D003093;D003424;D015212 | T047 |
36,225,103 | cost effect use valent pneumococc conjug vaccin direct protect adult england elev risk pneumococc diseas despit current pneumococc vaccin program england older adult adult under condit diseas burden remain high evalu cost effect valent pneumococc conjug vaccin pcv compar current pneumococc recommend adult england | D013222;D011008 | T047;T064 |
36,225,102 | synerg temperatur effect star like monodispers iron oxid nanoparticl relat respons normal cancer cell magnet nanoparticl mnp anisotropi tailor prepar mnps differ shape star like cubic polyhedr use self modifi rapid hot inject process surfac modif mnps perform etidron ligand graft strong bind affin mix metal oxid ensur suffici colloid stabil surfac protect minim aggreg interparticl interact heat effect induc contactless extern stimul action altern magnet field nir laser radiat nm efficaci energi convers evalu function particl shape concentr extern stimuli paramet turn effici star like particl select studi respons contact normal cancer cell found star like mnps fe sl nps mgml concentr induc necrosi signific alter cell cycl progress mgml stimul antioxid anti inflammatori respons normal cell biolog relev heat effect lead heat mediat cell death achiev mgml concentr star like particl enhanc addit ascorb acid aa aa mediat photomagnet hyperthermia lead modul heat shock respons cancer cell depend genotyp phenotyp variat cell line | D058185;D006979;D053758;D009369 | T191;T061;T073;T130 |
36,225,101 | ultrasmal pt nanozym immobil spheric polyelectrolyt brush robust peroxidas like activ high sensit detect cystein distinct platinum pt nanozym peroxidas mimic receiv extens interest owe outstand catalyt activ high environment toler lower consumpt great potenti replac natur enzym howev easi agglomer pt nanoparticl pt nps result high surfac free energi signific decreas peroxidas like activ herein spheric polyelectrolyt brush spb stabil ultrasmal pt nps spb pt nps prepar novel synthet strategi spb perform nanoreactor synthesi ultrasmal pt nps also great stabil pt nps aggreg well defin spb pt np nanozym exhibit outstand peroxidas like activ catalyt oxid colorless tetramethylbenzidin tmb blue oxid tmb use establish colorimetr sensor rapid detect cystein give limit detect moreov colorimetr detect system demonstr outstand perform sensit select detect cystein presenc sever interfer molecul result spb pt nps regard promis peroxidas mimic larg number applic biosens biomedicin food industri environment chemistri | D010984;D053768 | T196;T073 |
36,225,099 | pterostilben prevent tunicamycin induc intestin barrier damag target endoplasm reticulum stress oxid stress autophagi gut microbiota endoplasm reticulum er stress crucial factor pathogenesi intestin diseas pterostilben pt demonstr mitig er stress protect intestin disord investig effect pt tunicamycin tm induc intestin er stress intestin barrier damag vivo piglet vitro intestin porcin epitheli cell jejunum ipec j cell result indic pt prevent tm induc bodi weight loss vs kg improv intestin barrier integr goblet cell function tm challeng piglet p pt also inhibit er stress restor redox homeostasi autophag flux decreas apoptosi tm challeng jejunum tm expos ipec j cell p howev attenu effect pt tm treat ipec j cell blunt knockdown sirtuin p moreov pt increas ace index vs downregul preval phylum proteobacteria vs cecal microbiota tm challeng piglet p conclus pt allevi tm induc intestin barrier damag regul er homeostasi oxid stress autophag flux gut microbiota | D059865;D000069196 | T007;T001;T049 |
36,225,096 | columnar metaplasia esophagus present iron defici anemia children neurolog impair congenit esophag atresia background columnar metaplasia lower esophagus includ gastric intestin metaplasia children sever neurolog impair congenit esophag atresia often gastroesophag reflux diseas lead barrett esophagus form lower esophag columnar metaplasia precursor esophag adenocarcinoma guidelin specif requir presenc intestin metaplasia diagnosi case seri illustr iron defici anemia may primari symptom esophag columnar metaplasia children upper endoscopi essenti initi ongo evalu case report review case columnar metaplasia lower esophagus children sever neurolog impair esophag atresia child present mark iron defici anemia minim gastrointestin symptom conclus conclud columnar metaplasia esophagus may present iron defici anemia children neurolog impair congenit esophag atresia even without overt gastrointestin symptom accord propos earli endoscop evalu consid specif patient popul base literatur review also emphas need guidelin endoscop surveil children type columnar metaplasia lower esophagus given associ risk malign transform | D000740;D001471;D004933;D004938;D000090463;D009422 | T191;T047;T019 |
36,225,091 | effect hemodilut clot waveform analysi paramet clot factor thrombin generat assay dilut model base analysi healthi male blood donor background clot wave analysi cwa activ partial thromboplastin time aptt measur speed extent fibrin polymer plasma studi aim evalu effect hemodilut cwa paramet clot factor thrombin generat assay dilut model materi method platelet poor plasma obtain healthi male volunt dilut sodium chlorid analyz coagul profil cwa clot factor thrombin generat assay cwa includ paramet time depend variabl aptt rateacceler min min max magnitud signal chang delta result critic low activ clot factor mgdl fibrinogen determin dilut respect peak thrombin endogen thrombin potenti signific lower compar baselin dilut respect aptt correl decreas clot factor dilut subsequ becam abnorm valu chang rateacceler paramet parallel time cours clot factor activ dilut depend linear manner paramet indic intervent threshold critic low activ clot factor strongest correl observ clot factor aptt clot factor min delta peak thrombin r delta fibrinogen r conclus aptt signific correl clot factor rateacceler paramet delta chang variat thrombin fibrinogen generat find may help evalu coagul | D006438;D013917 | T121;T061;T126;T116 |
36,225,029 | high precis calibr zoom len optic measur machin base fnn propos calibr method high precis zoom lens optic measur machin base fulli connect neural network fnn use layer neural network instead camera calibr model achiev continu calibr zoom lens zoom set calibr typic zoom experiment verif averag calibr error method mm averag measur error zoom set mm overal calibr precis better zhang calibr method meet applic requir high precis optic measur machin method propos paper provid new solut new idea calibr zoom lens wide use field precis part inspect machin vision measur | D007909 | T073 |
36,225,026 | semant ghost imag base recurr neural network ghost imag gi illumin object sequenc light pattern obtain correspond total echo intens bucket detector correl pattern bucket signal result imag due mechan differ tradit imag method gi receiv extens attent past two decad howev mechan also make gi suffer slow imag speed poor imag qualiti previous work sampl includ illumin pattern detect bucket signal treat independ correl therefor linear superposit sequenti data inspir human speech sequenti word link certain semant logic incomplet sentenc could still convey correct mean propos differ perspect potenti non linear connect sequenti sampl gi therefor built system base recurr neural network rnn call gi rnn enabl recov high qualiti imag low sampl rate test mnist handwrit number show sampl rate gi rnn db higher tradit basic correl algorithm db higher compress sens algorithm imag qualiti train natur imag gi rnn exhibit strong general abil gi rnn work well standard imag cameraman also recov natur scene realiti sampl rate ssim greater | D016571;D012660 | T078;T170 |
36,225,023 | ultralow threshold green fluoresc protein laser base high q microbubbl reson biolog laser attract vast attent potenti medic applic prospect especi low threshold biolog laser use ultrasensit biolog detect leav lumin gain medium undamag pump light coupl low concentr green fluoresc protein gfp solut high q whisper galleri mode microbubbl reson manag fabric miniatur gfp laser lowest threshold highest q valu compar known type gfp laser threshold energi low fj two order magnitud lower type gfp laser present q valu optic caviti biolog laser two order higher highest q valu gfp laser confirm long term stabil work characterist gfp laser work well near month temperatur c final measur effect differ concentr fluoresc protein laser threshold data show biolog laser use high sensit detect gfp concentr particular use gfp use tracer | D007834;D045423 | T074;T073 |
36,224,995 | simul thermal field distribut biolog tissu cell cultur media irradi infrar wavelength recent year grow interest singlet form oxygen regul physiolog function cell one way generat singlet oxygen direct optic excit triplet oxygen form sinc molecular oxygen weak absorb light high power requir obtain suffici concentr singlet oxygen howev increas radiat power laser induc local temperatur increas around laser spot may critic consid temperatur govern everi biolog reaction within live cell particular interact laser radiat infrar wavelength generat singlet oxygen biolog tissu cell cultur media simul use comsol multiphys softwar thermal field distribut volum skin brain tissu cell cultur media obtain depend wavelength power exposur time result demonstr import take temperatur account conduct experiment studi cellular organism level | D007834;D026082 | T074;T123;T073;T196 |
36,224,983 | intellig dynam data perturb ocdm encrypt scheme base cellular neural network biolog genet encod paper intellig dynam perturb orthogon chirp divis multiplex ocdm encrypt scheme base cellular neural network biolog genet encod seven core optic fiber propos first time knowledg scheme chaotic sequenc generat cellular neural network employ construct six mask vector achiev six dimens ultra high secur encrypt transmit bit data interleav accord dna oper rule subcarri frequenc symbol matrix time scrambl select encod rule decod rule key base sequenc subcarri frequenc symbol matrix scrambl posit time chang dynam robust malici attack enhanc simultan ocdm technolog employ optim system effect improv anti interfer abil bit error perform system gb gb encrypt ocdm signal transmiss experi carri km core fiber orthogon frequenc divis multiplex ofdm signal transmit condit comparison verif result show key space newli propos encrypt scheme reach receiv sensit ocdm db greater ofdm bit error rate scheme improv secur encrypt inform perform system promis optic access network futur | D016571;D012815 | T170;T066 |
36,224,952 | declin suspend particul matter concentr lake taihu observ landsat tm oli suspend particul matter spm affect optic properti water use marker water qualiti water qualiti lake taihu chang immens sinc howev despit link water qualiti spm long term systemat studi spm conduct lake use landsat tm landsat oli data model chang spm concentr lake taihu various model generat calibr final valid use situ spm remot sens reflect r rs data synchron satellit data compar various common use model found exponenti model base band combin r rs red r rs nir r rs green highest accuraci averag unbias relat error greater subsequ spm product lake taihu generat overal spm concentr show downward trend studi period might primarili attribut declin wind speed find may assist conserv lake taihu associ water resourc | D004784;D060106;D052638 | T167;T131;T083;T057;T070 |
36,224,926 | direct detect virus like particl use color imag plasmon nanostructur propos measur method sensit label free detect virus like particl vlps use color imag nanoplasmon sens chip nanoplasmon chip consist gold nanoslit array gold surfac modifi specif antibodi spike protein reson wavelength nm period gold nanoslit array underwat environ nm fall green red band color ccd captur vlps specif antibodi shift plasmon reson gold nanoslit result increas bright green pixel decreas bright red pixel imag contrast signal green red red green show good linear surfac particl densiti experiment test show imag contrast method detect nm polystyren particl surfac densiti smaller particlesm demonstr applic direct detect sar cov vlps use simpl scanner platform detect limit smaller pgml detect time less minut achiev | D015374;D000086382;D049329 | T047;T073;T059;T075;T067 |
36,224,912 | simultan super resolut estim singl molecul posit orient minim photon flux orient singl molecul provid valuabl inform fundament biolog process report techniqu simultan estim singl molecul posit orient ultra high local precis nm precis photon typic nm diamet excit beam pattern also compat track live cell propos method theoret precis limit calcul local orient perform along potenti applic explor use numer simul compar camera base orient measur method confirm propos method obtain reason estim even weak signal photon moreov maximum likelihood estim mle found converg theoret limit total number photon less | D036103;D017785 | T090;T167 |
36,224,897 | dna sequenc frster reson energi transfer propos new dna sequenc concept base nonradi frster reson energi transfer fret donor quantum dot qd acceptor molecul fret mechan combin nanopor base dna transloc suggest novel concept sequenc dna molecul recent develop hybrid quantumclass method employ use time depend densiti function theori quasistat finit differ time domain calcul due signific absorb dna base photon energi higher ev biocompat stabil use zinc oxid zno qd donor fret mechan sensit propos method dna achiev hoechst fluoresc dye acceptor nm zno qd result show insert type dna nucleobas donor acceptor chang frequenc emit light acceptor molecul ev nois analysi show method determin unknown dna nucleobas signal nois ratio larger db propos concept excel result shed light new promis class dna sequenc | D045663;D015034 | T121;T073;T197 |
36,224,885 | bovin serum albumin label free concentr sensor base silica corros quantit monitor system bovin serum albumin bsa label free concentr sensor base silica corros quantit monitor system scqms propos anti reson hollow cylindr waveguid hcw scqms simul investig monitor corros rate quantit hydrofluor acid hf sampl differ concentr studi respect corros rate obtain demodul correspond anti reson dip shift free spectral rang fsr therefor high precis sqcms prepar success basi high sensit concentr sensor base hole assist dual core fiber hadf prepar bsa sampl concentr mgml mgml detect sensor high sensit nm mgml ultra low limit detect lod mgml assist core expos target solut direct demonstr scqms feasibl tool precis quantit corros silicon structur safe addit concentr sensor structur wide applic ultra low lod simpl prepar process high integr | D012710;D012822 | T123;T116;T130;T197 |
36,224,875 | frequenc switch photon spike neuron propos approach generat neuron like spike vertic caviti surfac emit laser vcsel multi frequenc switch stabl tempor spike sequenc realiz numer simul experi puls width sub nanosecond order magnitud faster one biolog neuron moreov control spike code scheme use multi frequenc switch design sequenc symbol generat speed gbps experi furthermor investig factor relat time delay spike generat includ inject strength frequenc detun proper manipul detun frequenc spike generat delay control upto ns time longer delay control intens multi frequenc switch provid anoth manipul dimens spike generat help exploit abund spatial tempor featur spike neural network believ propos vcsel neuron singl physic devic generat spike signal variabl time delay pave way futur photon spike neural network | D016571;D009474 | T025;T170 |
36,224,863 | uniform improv reconstruct holograph imag near eye display system use axi hoe near eye display ned devic reproduc imag locat close eye virtual imag implement larg angl uniform imag unbalanc due chang diffract effici hologram record angl angular select studi propos method implement optim uniform imag analyz diffract effici reconstruct imag analyz use angular select generat reproduc sourc point diffus imag intermedi element holograph optic element hoe research provid practic result display high diffract effici immers holograph imag ned system hoe uniform intermedi element | D006696;D055096 | T060;T073 |
36,224,845 | multi slice ptychograph imag multistag coars fine reconstruct abil imag sampl optic section essenti studi tomograph morpholog materi biolog scienc howev often hamper limit acquisit speed equip complex perform volumetr imag propos best knowledg new method reconstruct minimum four intens measur complementari structur pattern provid digit micromirror devic dmd irradi outermost layer sampl generat correspond diffract intens record enabl rapid scan load pattern fast acquisit multistag reconstruct algorithm first extract overal coars grain inform iter optim inform differ layer obtain fine featur therebi achiev high resolut tomographi high fidel reconstruct experi two slice resolut target unstain polyrhachi vicina roger freeli move c elegan prove robust method compar tradit reconstruct method interferometri base method fourier ptychograph tomographi fpt method increas reconstruct speed least time suitabl label free dynam imag multipl scatter sampl reconstruct suggest potenti applic wide rang field | D017173;D021621 | T062;T073;T060;T204 |
36,224,831 | adapt enhanc color gamut implic color vision color defici one strategi aid color defici use three narrow passband filter light spectrum increas satur color filter analog narrow emiss band use wide gamut light display examin percept adapt greater color gamut area produc devic test color normal observ simul environ narrowband spectra increas chromat contrast also increas contrast adapt partial offset perceiv contrast enhanc adapt adjust import understand perceptu consequ exposur natur artifici enhanc color gamut area color defici color normal observ | D055253;D003117 | T047;T040 |
36,224,828 | bio inspir spheric compound eye camera simultan wide band larg field view imag natur compound eye excel optic characterist name larg field view small size aberr sensit motion arthropod power vision exampl morpho butterfli compound eye perceiv near infrar ultraviolet light human eye see wide band imag larg field view great potenti wide area surveil weather panoram imag medic imag henc wide band spheric compound eye camera inspir morpho butterfli eye propos wide band spheric compound eye camera achiev larg field view imag wide rang wavelength nm nm main consist three part wide band spheric compound eye sub eye light collect wide band optic relay system light transmiss wide band cmos imag sensor photoelectr convers experiment result show wide band spheric compound eye camera captur larg field view without anomal blur aberr also perceiv near infrar light recogn human eye featur make possibl distort free panoram vision panoram medic diagnosi | D005123;D055096 | T023;T073 |
36,224,815 | numer simul optic refractometr sens multipl diseas marker base lab fiber multi paramet optic refractometr sensor base lab fiber propos sens properti investig base particular three suspend core fiber sensor three channel liquid circul three suspend core detect multipl diseas marker detect coat specif bio recognit layer surfac three channel bio recognit layer thick repres concentr diseas marker measur wavelength fiber bragg grate inscrib suspend core owe tripl symmetri fiber sensit core similar simul result show grate wavelength linear chang bio recognit layer thick variat sensit matrix sensit sensor nmnm sens accuraci nm | D055100 | T073 |
36,224,802 | subsurfac phytoplankton vertic structur observ use offshor fix platform base lidar bohai sea offshor respons typhoon bavi subsurfac phytoplankton vertic structur observ use offshor fix platform base lidar bohai sea first time lidar obtain two period continu day night measur week hybrid retriev method optic properti chllorophyl concentr vertic structur seawat use lidar data develop studi offshor subsurfac phytoplankton vertic variat respons typhoon bavi signific chang intens depth subsurfac phytoplankton maximum layer bohai sea may result horizon advect light avail rainfal dilut follow typhoon bavi preliminari result suggest lidar measur provid new approach understand ocean dynam mechan submeso mesoscal | D055867;D010839 | T002;T070 |
36,224,776 | deep learn signal clock exposur estim roll shutter optic camera communic roll shutter rs base optic camera communic occ link select appropri camera exposur time critic limit recept bandwidth long exposur pixel accumul time incom irradi sever consecut symbol result harm intersymbol interfer corrupt receiv signal consequ reduc exposur time requir increas recept bandwidth cost produc dark imag impractic light condit human machin supervis applic altern deep learn dl equal train mitig exposur relat isi equal must train consid transmitt clock camera exposur except challeng paramet unknown advanc eg camera reveal intern set case receiv must estim paramet direct imag sever distort exposur time work propos dl estim purpos train use synthet imag generat thousand repres case estim enabl receiv oper multipl possibl configur regardless camera use result obtain valid use real imag regist relat error lower estim transmitt clock exposur time respect obtain error guarante optim perform follow equal decod receiv stage keep bit error rate forward error correct limit estim central compon occ receiv oper moder exposur condit decoupl recept routin camera use ultim enabl cloud base receiv architectur | D000077321 | T066 |
36,224,764 | express immunogen sar cov virus like particl base recombin truncat hev orf capsid protein covid emerg diseas pose sever threat global public health urgent demand vaccin sar cov virus caus covid describ virus like nanoparticl candid vaccin sar cov produc e coli express system fusion protein truncat orf encod protein aa p hepat e virus ccjd receptor bind domain spike protein sar cov express purifi character antigen immunogen p rbd evalu vitro kunm mice investig reveal p rbd self assembl approxim nm virus like particl could bind serum vaccin peopl p receptor cell immun p rbd induc titer igg antibodi vaccin increas day post immun signific enhanc booster immun dpi ultim reach peak level dpi titer log pseudovirus neutral test show candid vaccin induc strong neutral antibodi respons mice research demonstr p rbd possess strong antigen immunogen could potenti candid use futur sar cov vaccin develop | D000086382;D016752;D014765 | T047;T121;T005;T129;T067 |
36,224,763 | acceler mesenchym epitheli transit met direct reprogram use natur compound induc pluripot stem cell ipsc generat somat cell use oct sox klf c myc oskm small molecul enhanc reprogram licochalcon lcd flavonoid compound present main root glycyrrhiza inflata act known signal pathway involv transcript activ signal transduct includ pgc mapk famili studi demonstr lcd improv reprogram effici lcd treat ipsc lcd ipsc express pluripot relat gene oct sox nanog prdm moreov lcd ipsc differenti three germ layer vitro form chimera mesenchym epitheli transit met critic somat cell reprogram found express level mesenchym gene snail twist decreas epitheli gene dsp cldn crb ocln dramat increas mef og rosa cell treat lcd day indic met effect occur lcd treat mef cell thus lcd enhanc generat ipsc somat cell promot met earli stage reprogram | D065150;D057026 | T043;T062;T025 |
36,224,762 | correl serum hepat b core relat antigen hepat b surfac antigen patient hepat b cirrhosi hepat b virus dna negat status retrospect studi studi aim examin correl serum hepat b core relat antigen hbcrag hepat b surfac antigen hbsag titer patient hepat b cirrhosi hepat b virus hbv dna negat status | D006509;D019694 | T047 |
36,224,760 | mixotroph cultiv nativ cyanobacterium pseudanabaena mucicola go produc phycobiliprotein biodiesel global warm acceler recent decad due continu consumpt petroleum base fuel cyanobacteria deriv biofuel promis carbon neutral altern fossil fuel may help achiev cleaner environ propos effect strategi base larg scale cultiv newli isol cyanobacteri strain produc phycobiliprotein biodiesel thus demonstr potenti commerci applic isol microalg strain nativ cyanobacterium isol goryeong korea identifi pseudanabaena mucicola go rna analysi potenti exploit p mucicola go explor analyz sever paramet mixotroph cultur optim growth achiev addit sodium acet gl bg medium next cultur scale stir tank bioreactor mixotroph condit maxim product biomass metabolit biomass phycobiliprotein fatti acid concentr sodium acet treat cell enhanc highest biodiesel product mgld achiev h final properti fuel deriv p mucicola go estim convert biodiesel accord composit fatti acid characterist final product except cloud point compliant intern biodiesel standard astm us en europ | D058086;D000458 | T007;T204 |
36,224,759 | preval diabet foot ulcer foot self care practic associ factor adult patient diabet south east ethiopia aim assess preval foot ulcer foot self care practic identifi associ factor adult patient diabet attend referr hospit south east ethiopia | D003924;D017719 | T047 |
36,224,757 | bavachin suppress alpha hemolysin express protect mice pneumonia infect staphylococcus aureus staphylococcus aureus aureus infect caus dramat harm human health well livestock develop import virul factor alpha hemolysin hla critic process aureus infect report found bavachin natur flavonoid effici inhibit hemolyt activ hla also capabl inhibit transcript translat level moreov data reveal bavachin neutral activ hla affect format hla heptam exhibit effect hla thermal stabil vitro assay show bavachin abl reduc aureus induc damag cell thus bavachin repress lethal pneumonia infect lung bacteri load lung tissu inflamm mice provid potent protect mice model vivo result indic bavachin potenti develop candid hla inhibitor aureus | D011023;D001427;D013203 | T131;T047;T123;T116 |
36,224,755 | identif valid novel biomark potenti target drug cholangiocarcinoma bioinformat virtual screen biolog evalu cholangiocarcinoma cca complex refractor type cancer global preval sever barrier remain cca diagnosi treatment prognosi therefor explor biomark therapeut drug cca manag necessari cca gene express data download tcga geo databas kegg enrich go analysi protein protein interact network use hub gene identif mirna predict use targetscan valid accord sever geo databas relat rna mirna express level prognost inform obtain gepia candid drug screen use pharmacophor base virtual screen valid molecular model sever vitro studi differenti express gene deg screen complement coagul cascad relat gene includ ahsg f ttr kng cell cycl relat gene includ cdk ccnb kiaa consid hub gene cca progress ahsg f ttr kng found signific decreas eight predict mirna target ahsg f ttr increas cca patient cdk ccnb kiaa found signific abund cca patient addit molport compound deriv pharmacophor base virtual screen could direct bind cdk exhibit anti tumor activ cholangiocarcinoma cell ahsg f ttr kng could novel biomark cca molport target cdk work potenti cell cycl inhibitor therebi potenti consider new chemotherapeut cca | D018281;D035683;D001650 | T191;T123;T114 |
36,224,754 | isovitexin protect mice methicillin resist staphylococcus aureus induc pneumonia target sortas rise methicillin resist staphylococcus aureus mrsa result signific morbid mortal clinic treatment mrsa infect becom extrem difficult sortas srta virul determin anchor numer virul relat protein cell wall prime druggabl target aureus infect due crucial role pathogen aureus demonstr isovitexin activ ingredi deriv varieti tradit chines medicin revers inhibit srta activ vitro low dose ic gml fluoresc quench molecular simul prove interact isovitexin srta subsequ point mutat experi confirm critic amino acid posit srta bind isovitexin ala ile trp addit isovitexin treatment dramat reduc aureus invas cell studi show treatment isovitexin could allevi patholog injuri prolong life span mice aureus pneumonia model accord research isovitexin repres promis lead molecul creation anti aureus medicin adjunct | D055624;D019881;D011014 | T050;T047;T116;T007;T126 |
36,224,753 | kifb regul tlr activ tlr signal pathway promot malign progress laryng cancer laryng cancer one highest incid preval diagnos head neck cancer make critic necessari probe effect target laryng cancer treatment real time quantit revers transcript pcr qrt pcr western blot analysi use detect gene express level laryng cancer cell line fluoresc situ hybrid fish subcellular fraction assay use detect subcellular locat function assay encompass cell count kit cck ethynyl deoxyuridin edu transwel wound heal assay perform examin effect target gene cell prolifer migrat laryng cancer vivo effect prove anim experi rna bind protein immunoprecipit rip rna pulldown luciferas report assay use investig under regulatori mechan result show kifb antisens rna kifb propel cell prolifer migrat laryng cancer regul toll like receptor tlr signal pathway kifb also recruit fus stabil tlr mrna consequ activ tlr signal pathway furthermor kifb play oncogen role laryng cancer via upregul tlr express well fustlr pathway axi find offer novel insight target therapi treatment laryng cancer patient | D062085;D007822;D035683 | T191;T123;T114 |
36,224,752 | effect long term fertil practic rhizospher soil autotroph co fix bacteria doubl rice ecosystem southern china soil autotroph bacteri communiti play signific role soil carbon c cycl paddi field littl known rhizospher soil microorgan respond differ long term year fertil practic doubl rice crop ecosystem southern china investig variat characterist rhizospher soil rubisco gene cbbl doubl rice ecosystem southern china fertil practic use experi set follow fertil regim without fertil input control ck inorgan fertil mf straw return rf organ inorgan fertil om found abund cbbl rrna gene rubisco activ rhizospher soil om rf mf treatment signific higher ck treatment abund cbbl rrna gene rhizospher soil om treatment time higher ck treatment respect rhizospher soil rubisco activ om rf treatment increas compar ck treatment shannon chao indic rhizospher soil cbbl librari rf om treatment increas compar ck treatment rhizospher soil cbbl sequenc mf rf om treatment main belong variovorax paradoxus uncultur proteobacterium ralstonia pickettii thermononospora curvata azoarcus spkhc meanwhil cbbl carri bacteri composit obvious influenc soil bulk densiti rhizospher soil dissolv organ c soil organ c microbi biomass c content fertil practic princip factor influenc rhizospher soil cbbl carri bacteri communiti result show rhizospher soil autotroph bacteri communiti signific chang condit differ long term fertil practic therefor increas rhizospher soil autotroph bacteria communiti crop residu organ manur practic found benefici manag doubl rice ecosystem southern china | D005308;D012275 | T168;T073;T002 |
36,224,748 | treatment outcom patient low energi logsplitt injuri low energi logsplitt fractur caus sprain fall character intact slight separ inferior tibiofibular joint compar high energi logsplitt fractur atyp subtyp rare seen easili miss case year old male patient fractur right ankl result sprain walk report patient initi receiv routin surgic treatment compris intern fixat fibular medial posterior malleoli unexpect post surgeri imag examin reveal medial clear space right ankl widen mm due incomplet reduct later malleolus shorten rotat fibula unreduc avuls fractur block anterior malleolus revis surgeri perform anatom reduc fix later malleolus well anterior malleolus avuls fractur month follow surgeri patient achiev good fractur union function restor right ankl rare injuri present case demonstr complet restor fractur requir achiev good clinic efficaci | D064386;D000071562;D013180 | T037 |
36,224,747 | serum cd concentr associ obes insulin resist non diabet individu cd lipopolysaccharid bind protein serv marker monocyt role circul cd patient obes without diabet remain unknown character relationship serum cd concentr metabol paramet relat diabet obes | D003924;D007333 | T047;T046 |
36,224,744 | clinic analysi pulmonari sarcomatoid carcinoma surgic treatment evalu clinic factor influenc postop pulmonari sarcomatoid carcinoma pscs prognosi | D002277;D008175 | T191 |
36,224,739 | new method combin hyperventil hypoxia train tactic fighter simul introduct physiolog episod issu militari aviat non pressur relat flight symptom prove due hyperventil rather hypoxia aim studi valid new train method provok hyperventil normobar hypoxia nh train fa hornet simul method doubl blind set fighter pilot finnish air forc perform setup wtsat simul random order full flight gear without pilot knowledg nitrogen co nitrogen turn ventil measur hypoxia p ecg monitor symptom document subject perform tactic identif flight recogn symptom hypoxia thereaft perform hypoxia emerg procedur return base gps malfunct execut instrument land system il approach waterlin hud mode evalu flight instructor scale result ventil increas normobar hypoxia nh l min l min p l min l min p co il flight perform similar min combin hyperventil hypoxia co advers effect report h follow discuss hyperventil provok normobar hypoxia train new well toler method meet nato standard agreement hypoxia train requir leinonen vari kokki hj leino tk new method combin hyperventil hypoxia train tactic fighter simul aerosp med hum perform | D000337;D008889;D000070356 | T091;T097 |
36,224,737 | blood glucos alter continu glucos monitor centrifug simul spaceflight introduct sympathet stimul known associ transient alter blood glucos bg concentr spaceflight acceler may similar associ alter bg potenti pose risk diabet individu engag futur spaceflight activ despit prior studi demonstr diabet subject toler centrifug simul spaceflight data lack regard blood glucos respons hypergrav remain unclear whether hypergrav associ physiolog respons may pose risk diabet continu glucos monitor cgm offer mean noninvas glucos monitor may use spaceflight analog environ describ result continu glucos monitor centrifug simul spaceflight method subject particip centrifug simul spaceflight profil maximum g z g x g result data collect includ heart rate blood pressur electrocardiogram continu glucos via cgm intermitt fingerstick bg postrun questionnair regard symptom relat hypergrav exposur result cgm data collect subject includ diabet diabet subject signific higher bg compar nondiabet associ differ symptom toler transient hypergrav associ cgm glucos alter affect toler centrifug experi cgm data found reliabl occasion except includ four instanc fals critic low glucos alarm discuss studi necessari better character cgm fidel hypergrav spaceflight relat stressor cgm may feasibl option spaceflight analog set prior studi individu well control diabet appear abl toler acceler anticip commerci spaceflight ong km rossitto jj ray k dufurrena qa blue rs blood glucos alter continu glucos monitor centrifug simul spaceflight aerosp med hum perform | D000337;D003920;D013026 | T047;T091;T057 |
36,224,732 | pilot mental health methodolog find systemat review introduct pilot mental health receiv increas attent follow germanw flight copilot intent crash aircraft french alp kill board investig incid found pilot depress disord method systemat review investig peer review studi pilot mental health publish sinc total paper identifi result two main methodolog employ questionnair databas record search anxieti depress suicid common investig mental health condit almost equal number studi found higher preval psycholog symptom pilot found lower preval relat control general popul preval rate higher studi reli sole questionnair studi employ databas record search discuss preval estim close associ methodolog difficult determin true rate factor might account low preval estim includ report symptom pilot reluct diagnos part health profession factor might account high preval estim includ anonym assess use questionnair align clinic disord inconsist cut score recommend futur studi preval use well valid clinic measur research conduct effect particular disord job perform ackland ca molesworth brc grisham jr lovibond pf pilot mental health methodolog find systemat review aerosp med hum perform | D000070356;D013405 | T097;T033 |
36,224,731 | simul space radiat exposur effect switch task perform rat background astronaut mission mar subject galact cosmic radiat gcr exposur ground base studi suggest simul gcr gcrsim exposur impair perform multipl cognit task impact exposur task switch perform import skill aviat yet determin method male wistar rat previous expos cgi ion gcrsim sham litterm train perform touchscreen base switch task design mimic warn light respons test use evalu pilot respons time result irradi rat fail complet high cognit task load train task threefold frequent sham sham gcr expos rat success complet initi train underw switch task test relat sham rat switch task gcrsim expos rat signific slower respons time switch repeat trial gcrsim expos rat signific p higher switch respons ratio switchrepeat trial respons time absolut switch cost switch minus repeat trial respons time either sham expos rat discuss rat expos gcrsim signific impair perform switch task manifest absolut switch cost ms oper signific increas requir investig ms switch cost result twofold increas cockpit error rate pilot exposur gcr space result similar effect human oper perform astronaut mar mission may suboptim stephenson britten r simul space radiat exposur effect switch task perform rat aerosp med hum perform | D003359;D000069079;D013026 | T057;T037;T070 |
36,224,729 | exercis ecg screen militari aircrew introduct exercis electrocardiogram execg stress test wide use screen tool occup medicin design detect occult coronari arteri diseas assess perform capac cardiovascular fit guidelin recommend high risk occup occult diseas could possibl endang public safeti aviat medicin howev ongo debat use period execg screen aircrew method german arm forc aircrew applic activ duti aircrew undergo screen execg analyz applic execg pilot nonpilot applic execg activ duti pilot perform german air forc centr aerospac medicin gafcam analyz ecg abnorm perform capac blood pressur heart rate respons result pilot applic requir investig none ultim disqualifi aircrew duti due execg result nonpilot applic requir diagnost work due execg find ultim disqualifi activ duti pilot execg reveal find requir investig pilot ultim disqualifi fli duti discuss extrem low yield execg find requir evalu andor disqualif aircrew duti suggest use question cost effect screen tool cohort may enough perform execg clinic indic alon guettler n nicol ed sammito exercis ecg screen militari aircrew aerosp med hum perform | D000337;D003324;D008889 | T047;T091;T097 |
36,224,717 | gestat diabet mellitus epigenet age offspr metabol report examin relationship utero exposur gestat diabet mellitus gdm offspr epigenet age acceler eaa offspr insulin sensit | D016640;D007333;D011297 | T047;T046;T037 |
36,224,715 | associ lagcd gene variant risk parkinson diseas sever recent studi suggest possibl role lymphocyt activ lag protein lag behav synuclein ligand serum cerebrospin fluid solubl lag level propos marker parkinson diseas pd studi aim investig whether associ common singl nucleotid variat snvs lag gene close relat cd molecul gene risk pd caucasian spanish popul two previous associ risk pd chines femal | D010300;D051844 | T047;T123;T116 |
36,224,712 | accommod popul differ valid risk predict model valid risk predict model independ data provid rigor assess model perform intern assess exampl done cross valid data use model develop howev sever differ popul gave rise train valid data lead seem poor perform risk model paper formal notion similar related train valid data defin reproduc transport address impact differ distribut model predictor differ verifi diseas status outcom measur calibr accuraci discrimin model individu level inform train valid data set avail propos studi weight version valid metric adjust differ risk factor distribut outcom verif train valid data provid comprehens assess model perform provid condit risk model popul gave rise train valid data ensur model reproduc transport show check condit use weight unweight perform measur illustr method develop valid model predict risk develop prostat cancer use data two larg prostat cancer screen trial | D055088;D011471 | T191;T058;T060 |
36,224,709 | mortal air pollut associ low exposur environ mapl phase mortal associ long term exposur fine particul matter particul matter aerodynam diamet pm although magnitud form associ remain poor understood lower concentr knowledg gap includ shape concentr respons curv lowest level exposur increas risk evid occurr extent associ specif caus death appli improv estim exposur ambient pm nation popul base cohort canada includ stack cohort million peopl respond census year character shape concentr respons relationship nonaccident mortal sever specif caus death low level exposur focus mortal air pollut associ low exposur environ mapl phase report phase report report associ outdoor pm concentr nonaccident mortal attenu addit ozon measur gaseous pollut oxid capac x estim nitrogen dioxid concentr motiv interest understand effect air pollut mixtur may mortal also role copollut share common sourc precursor emiss pm phase report explor sensit associ x evalu sensit factor region variat present ambient pm concentr respons relationship specif caus death | D000393;D000397;D004781;D009026 | T037;T131;T081;T069;T080 |
36,224,701 | applic protocol standard neonat parenter nutrit formul improv medic technolog prematur infant infant congenit intestin malform condit need parenter nutrit pn support surviv pn technolog becom import therapeut strategi neonat intens care unit due differ qualif medic staff hospit pharmaci manag hospit level etc composit prepar method pn prescript vari great differ region hospit china addit delay start time pn unreason formula nutrit compon poor prescript review larg workload involv prepar pn nurs wast drug prone happen view issu hospit independ develop standard formula neonat pn solut approv australia patent invent herein report composit applic protocol standard pn solut newborn | D007234;D010288 | T061;T100;T033 |
36,224,700 | relationship abo blood group pregnanc complic abo blood group system common use blood group classif system clinic practic relev antigen b h determin complex carbohydr molecul express red blood cell cell line tissu antigen determin abo locus locat chromosom q q abo blood group associ develop mani human diseas eg cardiovascular diseas infecti diseas tumor relationship abo blood group pregnant women various pregnanc complic includ preeclampsia pe relat diseas pregnanc associ venous thromboembol pa vte gestat diabet mellitus gdm postpartum hemorrhag pph becom focus obstetrician recent research interest herein review relationship abo blood group pregnanc complic found report find support follow view blood type protect factor pe blood type ab increas risk pe blood type prone pa vte blood type blood type blood type ab may relat pathogenesi gdm women blood type higher risk pph blood type depth epidemiolog genet studi need confirm find futur find provid new idea research pathogenesi obstetr diseas form theoret basi obstetrician prevent treat relat diseas | D016640;D011225;D011248;D054556 | T047;T046 |
36,224,699 | research progress relationship lactobacillus dental cari lactobacillus first microorgan found close associ dental cari demonstr acidogen acidur abil bind collagen synthes extracellular polysaccharid promot bacteri adhes lactobacilli inhibit growth cariogen bacteria produc antibacteri compound metabolit compet cariogen bacteria adhes site co aggreg regul express gene relat cariogen virul therefor research recent year experi appli lactobacillus probiot prevent control cari howev cariogen mechan lactobacillus still fulli understood potenti effect presum benefici specif lactobacillus oral intestin microecolog remain unknown research need done combin cariogen probiot properti lactobacillus comprehens evalu effect lactobacillus oral system health herein summar research progress cariogen cari prevent effect lactobacillus focus discuss role lactobacillus cariogenesi develop dental cari clinic prevent control dental cari order provid new idea refer prevent control dental cari | D003731;D007778 | T007;T047;T033 |
36,224,698 | materi select inhibit streptococcus mutan progress relev research dental cari diseas chronic progress destruct hard dental tissu occur influenc multipl factor among bacteri infect import one dental plaqu biofilm key factor pathogenesi dental cari normal circumst microorgan within biofilm maintain dynam balanc coordin competit antagon howev environ chang balanc biofilm disrupt number cariogen bacteria especi streptococcus mutan mutan increas signific therebi caus product larg amount organ acid tooth surfac tooth deminer format dental cari therefor find way restor dynam balanc oral microorgan select inhibit mutan key prevent treatment dental cari herein review research progress recent year develop materi select antibacteri effect intend provid refer develop drug prevent treatment dental cari futur studi focus follow aspect mechan clinic efficaci chemic modif safeti supplement make improv exist relev research promot progress research develop drug prevent treatment dental cari | D003731;D013295 | T007;T047;T033 |
36,224,697 | preliminari studi effect whole process case manag base servic process design function satisfact patient undergo total knee arthroplasti investig effect whole process case manag base servic process design patient undergo total knee arthroplasti tka area includ pain function satisfact complic | D019645;D020370 | T061;T047 |
36,224,696 | analysi characterist eye movement behavior young adult differ degre myopia measur paramet eye movement young adult patient myopia compar differ paramet patient group vari degre myopia analyz correl eye movement paramet axial length al spheric equival refract ser | D005133;D009216 | T047;T039 |
36,224,695 | chang predict social function disabl qualiti life patient major depress disord cours year medic investig chang social function impair qualiti life predict factor patient major depress disord mdd cours year drug treatment | D003865 | T048 |
36,224,694 | effect differ test strategi appli cervic cancer screen shuangliu district chengdu citi evalu clinic valu differ combin strategi high risk hpv hr hpv test thinprep cytolog test tct cervic cytolog test cervic cancer screen especi high higher grade squamous intraepitheli lesion hsil shuangliu district chengdu citi | D018290;D030361;D002583 | T191;T047 |
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