PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,224,559 | effect steroid administr fetal diaphragm function antenat steroid administr lead acceler lung matur improv blood gas measur also lung dynam lung complianc studi aim investig structur function chang diaphragm antenat steroid administr | D003964;D047928 | T023;T046 |
36,224,558 | develop valid extend cox prognost model patient erpr breast cancer retrospect cohort studi purpos studi explor new estrogen receptor er andor progesteron receptor pr human epiderm growth factor receptor breast cancer prognost model call extend cox prognost model determin cutoff valu multipl continu prognost factor interact via new model concept variabl select method | D001943;D011980 | T191;T116;T192 |
36,224,557 | compar diagnost perform cantones chines version rome iv criteria short refer standard function dyspepsia china function dyspepsia fd diagnos base self report symptom negat upper gastrointestin endoscop find rome criteria adopt diagnost instrument clinic guidelin due complex differ guidelin use relat simpl symptom assess scheme content vari signific previous evalu short refer standard may serv standardis tool guidelin evalu diagnost accuraci rome iv criteria cross section studi hong kong | D004415 | T184 |
36,224,556 | effect electromagnet wave pathogen virus relev mechan review pathogen viral infect becom serious public health issu worldwid virus infect cell base organ caus vari injuri damag result diseas even death preval high pathogen virus sever acut respiratori syndrom coronavirus sar cov urgent develop effici safe approach inactiv pathogen virus tradit method inactiv pathogen virus practic sever limit electromagnet wave high penetr capac physic reson non contamin emerg potenti strategi inactiv pathogen virus attract increas attent paper review recent literatur effect electromagnet wave pathogen virus mechan well promis applic electromagnet wave inactiv pathogen virus provid new idea method inactiv | D000086382;D014777 | T047;T067 |
36,224,555 | bayesian approach model under predictor earli recurr postop death patient colorect cancer studi aim util bayesian approach semi compet risk techniqu model under predictor earli recurr postop death patient colorect cancer crc | D015179 | T191 |
36,224,554 | inform invest health workforc bangladesh health labour market analysi global strategi human resourc health workforc gshrh outlin health system function health workforc hwf bangladesh commit achiev univers health coverag uhc henc comprehens understand exist hwf deem necessari inform polici fund decis health system | D006280;D019472 | T078;T081 |
36,224,553 | compar proteom analysi provid insight molecular mechan bud break longan time bud break import flower fruit longan obtain new insight under regulatori mechan bud break longan compar analysi conduct three flower induct stage two longan varieti opposit flower phenotyp use isobar tag relat absolut quantif itraq | D040901;D013214 | T091;T126;T116 |
36,224,552 | ultra sensit molecular detect gene fusion rna use aspyr rna critic analyt unambigu detect action mutat use guid treatment decis oncolog current avail method gene fusion detect includ molecular antibodi base assay suffer either limit singl gene target lack sensit long turnaround time sensit predict valu next generat sequenc dna base assay detect fusion sequenc intron region variabl due extens size intron requir depth sequenc input nucleic acid requir prohibit addit certain predict gene fusion actual express | D050939;D012313 | T063;T114 |
36,224,551 | sex differ determin covid sever outcom find nation covid cohort collabor nc impact comorbid biomark covid sever vari sex yet verifi popul base studi examin associ comorbid inflammatori biomark sever outcom men women hospit covid | D000086382 | T047;T067 |
36,224,549 | healthcar profession view follow implement risk stratif nation breast cancer screen programm crucial determin feasibl risk stratifi screen facilit success implement introduc risk stratif bc predict nhs breast screen programm nhsbsp three screen site north west england present studi investig view healthcar profession hcps accept barrier facilit bc predict intervent wider implement risk base screen bc predict implement screen site | D001943;D055088 | T191;T058;T060 |
36,224,548 | concurr valid dorsavi wireless motion sensor system version vicon motion analysi system lift wearabl sensor technolog may allow accur monitor spine movement outsid clinic set concurr valid wearabl sensor multiplan task lift unknown studi assess dorsavi version sensor concurr valid vicon motion analysi system measur lumbar flexion lift | D017770;D009068;D000076251 | T073;T040;T052 |
36,224,547 | famili risk associ lung cancer second primari malign first degre relat aggreg lung cancer lca famili member well document howev littl known famili risk lca first degre relat fdrs parent sibl diagnos lca second primari malign lca aim investig whether extent famili histori lca associ increas lca risk | D008175;D016609 | T191 |
36,224,546 | pilot evalu assess effect youth peer communiti support via kooth onlin mental wellb websit mental health problem among young peopl grow concern global uk adolesc mental health servic increas restrict sever need mani young peopl turn internet advic support littl known effect potenti harm onlin support kooth wide use anonymis moder onlin platform offer access profession peer support pilot evalu sought assess chang wellb mental health kooth user chang use formal servic one month explor communiti aspect site use consid econom implic commission make kooth avail young peopl | D000091443;D008603 | T054;T041 |
36,224,545 | veba modular end end suit silico recoveri cluster analysi prokaryot microeukaryot viral genom metagenom advent metagenom import microorgan interact relev ecosystem resili sustain human health becom evid catalog preserv biodivers paramount earth natur system also discov solut challeng face grow civil metagenom pertain silico studi microorgan within ecolog communiti situ howev mani softwar suit recov prokaryot limit support virus eukaryot | D001105;D054892 | T194;T028 |
36,224,544 | sleep cycl children sever acut bronchopneumonia mechan ventil differ depth sedat investig characterist sleep cycl children sever acut bronchopneumonia treat invas mechan ventil differ sedat depth | D001996;D012121 | T061;T047 |
36,224,543 | audit function prepared select militari hospit respons incid disast participatori action research sinc hospit play import role deal disast victim studi conduct audit function prepared select militari hospit respons incid disast | D004189;D004190 | T064;T067;T052 |
36,224,542 | efficaci safeti combin empagliflozin metformin combin sitagliptin metformin ramadan observ studi manag diabet fast clinic challeng sodium glucos co transport inhibitor sglti consid safe low risk hypoglycemia howev studi sglti scarc studi design compar efficaci safeti toler empagliflozin metformin ramadan comparison sitagliptin metformin | D003924;D007003;D008687;D000077203;D027981 | T047;T116;T121;T109;T123 |
36,224,541 | doula support among brazilian women attend sens birth health educ intervent cross section analysi matern health prioriti intern goal matern health outcom remain poor mani region world brazil matern mortal decreas past decad countri matern mortal ratio higher half countri death per live birth brazilian matern health care model facilit high rate medic intervent labor childbirth birth cesarean birth doula support consid potenti strategi reduc medic unnecessari intervent childbirth contribut matern mortal | D059037;D006266;D012944 | T058;T065;T097;T054 |
36,224,540 | implement advanc care plan decis aid patient undergo high risk surgeri field test studi patient undergo high risk surgeri risk sudden deterior health studi aim examin feasibl develop two patient decis aid ptdas assist patient undergo high risk surgeri inform decis make medic care crisi | D032722;D003661 | T090;T058;T170 |
36,224,539 | analysi antibiot use clinic outcom adult known suspect pleural empyema prevail consensus appropri antibiot choic rout durat treatment bacteri pleural empyema appropri sourc control profession societi guidelin note lack compar trial guid recommend assess clinic outcom treatment known suspect empyema base upon three aspect antibiot use total durat durat intraven iv antibiot durat anti anaerob antibiot | D000900;D016724 | T121;T047;T195 |
36,224,538 | long term outcom lamivudinedolutegravir dual therapi hiv infect virolog suppress patient use dtg contain two drug regimen one promis solut need eas manag hiv treatment without harm efficaci safeti report long term result patient switch virolog suppress combin dolutegravir dtg plus lamivudin tc | D019380;D015658;D015497 | T121;T047;T005 |
36,224,537 | post fractur serum cytokin level associ later diagnosi complex region pain syndrom case control studi nest prospect cohort studi complex region pain syndrom crps disabl pain disord common distal limb fractur acut system immun respons injuri thought play role develop crps hypothesi never test direct thus evalu whether elev level circul pro inflammatori cytokin earli fractur associ develop crps | D020918;D016207 | T047;T116;T129 |
36,224,536 | conduct report qualit evid synthes health social care guidelin content analysi paper part broader investig way health social care guidelin produc use qualit evid synthes qess alongsid establish method guidelin develop systemat review meta analys quantit data studi content analysi qess produc year period lead provid guidelin nation health servic uk nation institut health care excel explor close match report framework qes | D019317;D013222 | T091;T064 |
36,224,534 | target ubr hepatocellular carcinoma cell precis treatment via echinacosid nanodeliveri hepatocellular carcinoma hcc among common malign cancer effect therapeut approach echinacosid ech phenylethanoid glycosid isol chines herbal medicin cistanch salsa inhibit hcc progress howev poor absorpt low bioavail limit biolog applic | D006528;D004365;D008113 | T191;T123;T121 |
36,224,533 | correl studi multiplanar reconstruct trigemin nerv angul trigemin neuralgia neurovascular compress nvc produc morpholog chang trigemin nerv root consid caus trigemin neuralgia tn patient tn found nvc also nvc found asymptomat individu mani studi found tight relationship tn morpholog structur trigemin nerv design studi explor correl multiplanar reconstruct mpr trigemin nerv angul tna tn | D014277 | T047 |
36,224,532 | factor associ birth asphyxia among term singleton birth two referr hospit northern uganda cross section studi birth asphyxia one lead caus neonat mortal worldwid uganda account neonat death view inform polici practic intervent reduc advers neonat outcom aim determin preval factor associ birth asphyxia two referr hospit northern uganda | D001238;D013587 | T047 |
36,224,531 | c jun mediat mir b express induc endotheli barrier dysfunct vitro model hemorrhag shock previous data demonstr mir b express increas human lung microvascular endotheli cell vitro vivo patient hemorrhag shock lead decreas syndecan mrna protein result loss endotheli barrier function howev mechan under increas mir b express remain unclear object current studi determin c jun mediat earli respons microrna mir b caus endotheli barrier dysfunct | D035683;D012771 | T046;T123;T114 |
36,224,530 | subtyp distribut lymphoma northwestern iran retrospect analysi case accord world health organ classif distribut lymphoma subtyp differ strike geograph variat howev limit inform research northern iran studi aim evalu incid subtyp age sex extranod distribut lymphoma diagnos accord latest classif larg referr center northwest iran | D006689;D008223;D016393 | T191 |
36,224,529 | simul base holist educ physiotherapi intern increas empathi toward older adult individu disabl proport older adult individu disabl general popul increas year thus clinic clerkship design physiotherapi intern provid simpli knowledg skill intern abl handl requir futur job clerkship must enabl develop empathi posit attitud toward patient studi investig effect simul base holist health care educ physiotherapi intern empathi attitud knowledg method parallel group design thirti physiotherapi intern medic institut enrol particip experiment control group compris particip group receiv standard clinic train howev experiment group receiv addit h simul base holist health care educ jefferson scale empathi kogan attitud toward old peopl scale attitud toward elder scale knowledg age scale knowledg situat older peopl scale percept work older peopl scale care willing scale use pretest posttest | D006233;D004645 | T101;T054;T055 |
36,224,528 | improv chronic kidney diseas detect treatment unit state chronic kidney diseas cascad care c studi protocol major gap implement guidelin concord care person chronic kidney diseas ckd ckd cascad care c initi seek improv ckd care improv detect treatment ckd primari care | D055316;D051436 | T121;T047;T116 |
36,224,527 | effect urinari extracellular vesicl prostat cancer patient transcriptom cancer associ normal fibroblast increas evid suggest cancer deriv extracellular vesicl ev alter phenotyp function fibroblast trigger reprogram normal fibroblast cancer associ fibroblast caf first time studi effect urinari ev pc patient healthi male transcript landscap prostat caf normal foreskin fibroblast | D000072645;D000067128;D011471 | T191;T025;T026 |
36,224,526 | accept parent experienc mental health challeng find e health intervent mental health postnat period systemat review poor mental health postnat period experienc high number parent high associ cost societi howev access therapeut support time complic parent commit compound covid pandem access tradit therapi impact lack access support poor mental health period long term impact parent child e health provid potenti solut parent access support period provid conveni flexibl intervent overcom barrier tradit face face therapi howev without investig accept support parent possibl predict uptak consequ effect current review synthes data avail accept e health intervent post natal period find parent valu e health intervent howev consider must made certain key area impact accept intervent parent element therapist support individualis content prefer along smooth user experi parent valu e health fit routin provid anonym interact research need complet accept minor social ethnic group access prefer may differ | D000086382;D017216 | T047;T058;T067 |
36,224,525 | effect temperatur water potenti germin seed three differ popul biden pilosa potenti cd hyperaccumul biden pilosa l annual herb recent shown potenti cd hyperaccumul plant germin characterist b pilosa document differ among popul remain unclear understand variabl seed germin among popul crucial determin popul use soil remedi program | D031176;D018525 | T038;T002 |
36,224,524 | treatment outcom recurr versus de novo metastat pancreat adenocarcinoma real world studi major patient undergo curat intent surgeri pancreat ductal adenocarcinoma pdac unfortun develop recurr diseas treatment outcom patient metastat diseas remain suboptim studi evalu clinic outcom patient recurr pdac receiv system therapi compar outcom patient de novo metastat pdac undergo system therapi | D000230;D021441;D010190 | T191 |
36,224,523 | fitmom experiment investig effect social media bodi dissatisfact eat physic activ intent attitud behaviour among postpartum mother research shown bodi dissatisfact higher postpartum period compar period life strong associ disord eat behaviour lead advers health outcom result cross section studi suggest social media may play import role bodi dissatisfact among postpartum mother causal infer limit due observ natur exist research object studi experiment test effect bodi focus social media bodi dissatisfact eat physic activ intent attitud behaviour postpartum mother | D000079182;D001068;D061108 | T055;T047;T170;T048 |
36,224,521 | umbil cord blood concentr connect peptid c peptid pregnanc outcom c peptid offer potenti marker indic childhood metabol outcom measur c peptid concentr might better futur util risk stratif neonat born overweight diabet mother prior research tri bring matter light howev clinic signific associ still far reach sought investig associ fetomatern metabol variabl umbil cord blood c peptid concentr | D016640;D011256 | T047;T033 |
36,224,520 | comparison unweight item respons theori base weight sum score nine question depress rate scale northern thai dialect nine question depress rate scale q develop altern assess tool assess sever depress symptom thai adult tradit unweight sum score approach account differ load item actual sever therefor develop item respons theori irt base weight sum score approach provid score method precis unweight sum score | D003863;D003865 | T184;T048 |
36,224,519 | european headach feder ehf consensus definit effect treatment migrain attack triptan failur triptan migrain specif acut treatment well accept definit triptan failur need clinic practic research primari aim present consensus provid definit triptan failur develop definit deem necessari develop first consensus definit effect treatment acut migrain attack triptan respond | D008881;D014363 | T121;T047;T109;T123 |
36,224,518 | comparison meiotic transcriptom three maiz inbr differ origin reveal differ cell cycl recombin cellular event meiosi differ inbr line maiz substanti differ averag number chiasmata doubl strand break dsbs per meiotic cell document among divers inbr line maiz cml tropic maiz inbr line b mo temper maiz line determin gene express might explain observ differ rna seq experi perform cml male meiocyt compar b mo male meiocyt plant grown control environ | D053903;D003313 | T168;T002;T049 |
36,224,505 | predict risk obes meal plan reduc obes adulthood use artifici intellig unhealthi diet excess amount food intak creat obes issu human be may caus sever diseas polycyst ovari syndrom pcos cardiovascular diseas diabet cancer etc obes major risk factor pcos common diseas women signific correl weight gain | D001185;D062407 | T073;T066;T090;T056;T079 |
36,224,497 | natur occur spike mutat influenc infect immunogen sar cov mutat sar cov variant concern voc enhanc transmiss immun evas respect current vaccin neutral antibodi nab natur occur spike mutat affect infect antigen voc remain investig entri effici individu spike mutat determin vitro use pseudotyp virus balbc mice immun dose dna vaccin encod b b b singl mutat cellular humor immun respons compar determin impact individu mutat immunogen b lineag del del ntd ad ph sd sa dh signific increas viral entri wherea ti result decreas b lineag lf del ntd kn rbd av also increas viral entri sa weaken generat bind antibodi sera show reduc cross neutral activ b b delta b omicron ba sa lf del hinder induct cross nab wherea del del ri kn show opposit effect b elicit adequ broad cross nab b b immunogen test howev show low neutral circul b addit cell respons unlik affect mutat test spike conclud individu spike mutat influenc viral infect vaccin immunogen design voc target vaccin like necessari overcom immun evas current vaccin neutral antibodi | D000086382;D000086402;D064370 | T047;T116;T005;T123;T067 |
36,224,482 | almost period model describ phenolog mismatch mutualist interact studi season mutualist interact two speci model take account climat mediat shift chang phenolog mutualist speci show condit paramet model guarante global stabil numer simul perform differ scenario associ season chang show period time depend use approxim almost period one densiti mutualist popul also overlap interv describ interv co occurr either underestim overestim therefor use almost period model adequ design conserv strategi asynchron phenolog | D057231;D002980 | T070 |
36,224,475 | therapeut landscap advanc posit breast cancer posit breast cancer aggress subtyp breast cancer five year surviv rate advanc stage develop anti treatment led paradigm shift manag clinic outcom advanc posit breast cancer patient standard first line treatment consist taxan base chemotherapi plus dual anti therapi trastuzumab pertuzumab antibodi drug conjug adc ado trastuzumab emtansin dm second line therapeut standard second line treatment approach rapid evolv given substanti advantag anoth adc fam trastuzumab deruxtecan dxd compar dm recent random trial second line set dxd current prefer second line option optim third line treatment strategi still establish multipl approach use includ combin base capecitabin trastuzumab oral anti tyrosin kinas inhibitor tucatinib plus capecitabin trastuzumab lapatinib plus trastuzumab neratinib lapatinib plus capecitabin fda approv combin anoth newer agent approv third later line therapi metastat set margetuximab fc engin anti monoclon antibodi combin chemotherapi novel agent current clinic trial drug indirect target includ immun cell cycl inhibitor pikmtor inhibitor immunotherapi agent | D001943;D018796;D008453 | T191;T109;T121;T129 |
36,224,474 | contribut b cell intrins toll like receptor adapt immun respons viral infecti diseas toll like receptor tlrs compris class high conserv molecul recogn pathogen associ molecular pattern play vital role host defens multipl viral infecti diseas although tlrs high express innat immun cell play indirect role regul antivir adapt immun respons intrins express tlrs adapt immun cell includ cell b cell ignor tlrs express cd cd cell play role enhanc tcr signal induc cell activ prolifer function surviv serv costimulatori molecul gene knockout tlr signal molecul shown diminish antivir adapt immun respons affect viral clearanc multipl viral infecti anim model result highlight critic role tlrs long term immunolog control viral infect review summar express function tlr signal pathway b cell focus vitro vivo mechan effect intrins tlr signal regul b cell respons viral infect potenti clinic use tlr base immun regulatori drug viral infecti diseas also explor | D003141;D000069452 | T085;T047;T123 |
36,224,472 | morin inhibit colon cancer stem cell inhibit pum express vitro last decad number peopl diagnos cancer increas dramat everi year make major caus mortal today colon cancer third common cancer worldwid second mortal rate current cancer treatment fail treat colon cancer complet due remain cancer stem cell cscs morin flavonoid present fig ficus carica plant sourc found anti prolif effect colon cancer model cell line studi effect colon cscs studi test potenc morin inhibit cscs found morin signific reduc colon cancer cell prolifer coloni format migrat colonospheroid format dose depend manner pumilio pum shown play import role colon cscs mainten found morin good bind affin pum protein one hydrophob two hydrogen bond interact immunofluoresc result also shown reduct pum express colon cancer cell line morin treatment cd overexpress colon cscs morin treatment reduc cd express hct ct colon cancer cell line research outcom explor anti cancer stem cell potenc morin via target pum protein reduc colon spheroid format reduc cd express colon cancer cell | D003110;D014411 | T191;T025 |
36,224,471 | inhibitor brd gne inhibit growth glioblastoma cell target c myc sa among children glioblastoma gbms relat common type brain tumor brd express elev gbm negat correl prognosi glioma investig anti gbm effect novel brd inhibitor gne | D001932;D005909 | T191 |
36,224,467 | critic review adsorpt recoveri fluorid wastewat metal base adsorb rapid industri deterior water qualiti fluorid pollut water one serious environment pollut problem adsorpt technolog effici select process remov fluorid aqueous solut use adsorb metal base adsorb synerg advantag fast adsorpt high adsorpt capac excel select effect remov fluorid water bodi promis satisfi environment sustain requir paper review metal base adsorb iron base aluminum base lanthanum base cerium base titanium base zirconium base multi metal composit adsorb primarili focus adsorpt condit fluorid remov capac discuss prospect challeng synthesi applic metal base adsorb paper aim stimul new think innov develop next generat sustain adsorb | D014874;D018508 | T057;T131;T052 |
36,224,464 | current status system construct use furnitur recycl china promot develop green low carbon wood industri explor current status trend china use furnitur recycl paper summar research status use furnitur recycl interpret government strategi develop use furnitur recycl system way handl use furnitur manufactur attitud custom toward use furnitur extens literatur review market research three respect govern furnitur manufactur consum problem nation use furnitur recycl analyz exampl imperfect system high cost weak awar therefor solv issu necessari construct nation use furnitur recycl system method govern pay attent construct recycl network supervis support entrepreneuri respons formul recycl standard furnitur manufactur improv durabl recycl furnitur develop new model new technolog furnitur recycl transport primari assign consum improv concept consum environment protect focus sum aim provid suggest amelior measur method support understand chang use furnitur recycl china | D018505;D060389 | T068;T090 |
36,224,441 | investig molecular mechan under jakstat signal pathway hpv induc cervic carcinogenesi use omic approach precis mechan action janus kinas jak signal transduc activ transcript stat signal human papillomavirus hpv associ cervic cancer cacx poor defin present studi dissect under compon jakstat signal hpv posit cervic neoplasm whole transcriptom profil cacx cohort tcga databas reveal elev stat impact cacx patient surviv use rt profil pcr array analyz gene interest associ jakstat signal mrna deriv hpv negat hpv posit cervic lesion reveal differenti express gene deg analys deg use databas annot visual integr discoveri tool indic maximum gene enrich immun respons negat regul apoptot process protein protein network analysi indic il stata stat jak key gene interact network key deg ilr irf egfr oa pia stat stata valid tcga cohort use r platform gene differenti express among hpv posit cervic tissu correl stat establish egfr ilr show compar strong correl stat support involv pathogenesi cacx final kaplan meier analysi establish prognost associ key deg cacx cohort stat associ key gene discov studi establish strong pathogen role jakstat pathway hpv mediat cervic carcinogenesi | D052685;D030361;D002583 | T191;T047;T005 |
36,224,440 | verifi unfamiliar ident effect process name face inform ident match task match ident unfamiliar face import appli ident verif task exampl verifi photo id border cross secur access area issu ident credenti set biograph detail name date birth ident document also often compar exist record impact concurr check decis examin ask particip sequenti compar name face inform id card digit record detect error across four experi combin n despit told mismatch written name pair face imag pair independ particip like say face imag match name also match across experi found bias unaffect imag qualiti suggest sourc bias somewhat independ perceptu process final experi show decision bias found name check particip ask check id card expir date unrel object name conclud bias aris process ident inform propos oper level unfamiliar person ident represent result interpret context theoret model face process discuss appli implic | D000066499;D009275 | T041;T170 |
36,224,430 | hdac inhibitor vorinostat bet inhibitor plx epigenet agent combin treatment exert therapeut approach upon acut myeloid leukemia cell model process cancer initi develop regul via transcript express cell go genom epigenet chang target epigenet reader ie bromodomain brd post translat modif nucleosom histon protein regul gene express cancer healthi cell studi new epigenet agent brd inhibitor plx histon deacetylas hdac inhibitor saha vorinostat singlecombin applic reflect analyz case cell prolifer cytotox apoptosi cell cycl arrest final target gene express regul upon aml healthi b lymphocyt cell hl ncibl respect vitro sinc mono treatment either vorinostat plx regul cellular respons growth prolifer apoptosi cell cycl arrest tumor cell combin treatment exert acceler result detect combin treatment plx vorinostat strengthen effect detect upon leukem cell gain sensit agent decreas cell prolifer dramat induc apoptosi cell cycl arrest thus regul target gene express shown first time newli analyz brd inhibitor plx could promis therapeut approach hematolog malign mono combin usag might support rapid transit clinic trial | D000970;D015470 | T121;T109;T191 |
36,224,418 | multi environ robot transit adapt morphogenesi current prolifer mobil robot span ecolog monitor warehous manag extrem environ explor individu consum home expand frontier applic requir robot transit multipl environ substanti challeng tradit robot design strategi effect address exampl biomimet design copi anim morpholog propuls mechan gait constitut one approach lose benefit engin materi mechan exploit surpass anim perform approach add uniqu propuls mechan environ robot bodi result energi ineffici design overal predomin robot design strategi favour immut structur behaviour result system incap special across environ achiev special multi environ locomot terrestri aquat transit zone implement adapt morphogenesi design strategi adapt robot morpholog behaviour realiz unifi structur actuat system take inspir terrestri aquat turtl built robot fuse tradit rigid compon soft materi radic augment shape limb shift gait multi environ locomot interplay gait limb shape environment medium reveal vital paramet govern robot cost transport result attest adapt morphogenesi power method enhanc effici mobil robot encount unstructur chang environ | D032701;D004777;D004867;D012371 | T090;T057;T067;T082 |
36,224,417 | matur circuit integr transplant human cortic organoid self organ neural organoid repres promis vitro platform model human develop diseas howev organoid lack connect exist vivo limit matur make integr circuit control behaviour imposs show human stem cell deriv cortic organoid transplant somatosensori cortex newborn athym rat develop matur cell type integr sensori motiv relat circuit mri reveal post transplant organoid growth across multipl stem cell line anim wherea singl nucleus profil show progress corticogenesi emerg activ depend transcript program inde transplant cortic neuron display complex morpholog synapt intrins membran properti vitro counterpart enabl discoveri defect neuron deriv individu timothi syndrom anatom function trace show transplant organoid receiv thalamocort corticocort input vivo record neural activ demonstr input produc sensori respons human cell final cortic organoid extend axon throughout rat brain optogenet activ drive reward seek behaviour thus transplant human cortic neuron matur engag host circuit control behaviour anticip approach use detect circuit level phenotyp patient deriv cell otherwis uncov | D009434;D009940 | T023;T024 |
36,224,415 | person exoskeleton assist walk real world person exoskeleton assist provid user largest improv walk speed energi economi requir lengthi test unnatur laboratori condit show exoskeleton optim perform rapid real world condit design portabl ankl exoskeleton base insight test versatil laboratori testb develop data driven method optim exoskeleton assist outdoor use wearabl sensor found equal effect laboratori method identifi optim paramet four time faster perform real world optim use data collect mani short bout walk vari speed assist optim one hour naturalist walk public set increas self select speed reduc energi use travel given distanc compar normal shoe assist reduc metabol energi consumpt particip walk treadmil standard speed human movement encod inform use person assist devic enhanc perform | D000067190;D016138 | T169;T074;T056 |
36,224,408 | fu dietari flavonoid carvacrol synergist combin induc apoptosi mcf breast cancer cell along benefit chemotherapi treatment breast cancer side effect drug along drug resist make use complic one solut overcom problem use herbal product combin therapi research tri investig effect carvacrol monoterpen flavonoid combin chemotherapi drug fu combin index method use drug drug interact analysi base chou talalay method data mtt assay apoptosi assess elisa cell death method p glycoprotein express evalu gene level real time pcr describ first experiment evid exist synerg carvacrol fu vitro model breast cancer mtt assay result show combin treatment cell carvacrol fu decreas fu concentr signific incub cell carvacrol neutral p glycoprotein overexpress qpcr assay p compar ad verapamil p glycoprotein inhibitor fu combin carvacrol fu caus increas percentag apoptot cell cell treat agent result suggest carvacrol downregul p gp express combin therapi carvacrol fu consid novel approach improv efficaci chemotherapeut cancer patient high p glycoprotein express | D001943 | T191 |
36,224,407 | vitro cytotox anti cancer drug releas behavior methionin coat magnetit nanoparticl carrier novel specif drug deliveri vitro cancer target develop success simpl one step method cofe methionin core shell nanoparticl prepar reflux assay amino acid surfac make ferrit biocompat enhanc chemic stabil improv drug load capac synthes nanoparticl character use ftir tga xrd sem tem vsm coat amino acid surfac cofe confirm xrd tga appear new peak cn confirm format letrozol load carrier ftir vibrat sampl magnetomet bare cofe methionin coat cofe nanoparticl exhibit room temperatur superparamagnet behavior satur valu emug emug respect morpholog size sampl character sem tem averag size particl around nm load letrozol effect ph releas behavior carrier studi result drug releas ph equal higher ph equal also prepar evalu determin cytotox use mcf mda mb mcfa cell vitro model result vitro experi show cofe methionin could signific reduc cancer cell model result demonstr core shell nanoparticl prepar biocompat potenti use drug deliveri | D000970;D058185;D053758 | T121;T109;T073;T130 |
36,224,405 | ndr activ cd transcript increas protein stabil nuclear locat ascl enhanc cancer stem cell properti evas phagocytosi small cell lung cancer small cell lung cancer sclc one malign type lung cancer cancer stem cell csc tumor immun evas critic develop sclc previous report ndr enhanc breast csc properti ndr might also role regul immun respons current studi explor function ndr control csc properti evas phagocytosi sclc find ndr enhanc enrich aldefluor high cd high popul promot sphere format sclc cell addit ndr upregul cd express enhanc evas phagocytosi sclc furthermor effect ndr enhanc cd express evas phagocytosi promin csc non csc import ndr promot ascl express enhanc ndr promot csc properti evas phagocytosi sclc cell mechan ndr enhanc protein stabil nuclear locat ascl activ transcript cd sclc final cd block antibodi use target ndr enhanc csc properti evas phagocytosi suppress egfr activ sclc summari data indic ndr could critic factor modul csc properti phagocytosi sclc | D008175;D055752 | T191 |
36,224,402 | antibodi respons third booster dose sar cov vaccin adult haematolog solid cancer systemat review patient live cancer signific increas risk morbid mortal infect sever acut respiratori syndrom coronavirus sar cov systemat review aim investig current avail evid immunogen sar cov booster vaccin patient live cancer | D014765;D000086382;D009369 | T047;T121;T191;T129;T067 |
36,224,396 | satur map common genet variant associ human height common singl nucleotid polymorph snps predict collect explain phenotyp variat human height identifi specif variant associ region requir huge sampl size use data genom wide associ studi million individu divers ancestri show independ snps signific associ height account near common snp base herit snps cluster within non overlap genom segment mean size around kb cover genom densiti independ associ vari across genom region increas densiti enrich biolog relev gene sampl estim predict snps snps hapmap panel account phenotyp varianc popul european ancestri around popul ancestri effect size associ region gene priorit similar across ancestri indic reduc predict accuraci like explain linkag disequilibrium differ allel frequenc within associ region final show relev biolog pathway detect smaller sampl size need implic causal gene variant overal studi provid comprehens map specif genom region contain vast major common height associ variant although map satur popul european ancestri research need achiev equival satur ancestri | D001827;D020641;D002874 | T062;T063;T032;T086 |
36,224,394 | movement govern rotat neural dynam spinal motor network although generat movement fundament function nervous system under neural principl remain unclear flexor extensor muscl activ altern rhythmic movement walk often assum respons neural circuitri similar exhibit altern activ present ensembl record neuron lumbar spinal cord indic rather altern popul perform low dimension rotat neural space neural activ cycl phase continu rhythmic behaviour radius rotat correl intend muscl forc perturb low dimension trajectori modifi motor behaviour exist model spinal motor control offer adequ explan rotat propos theori neural generat movement unresolv issu speed regul forc control multifunct readili explain | D009068;D013116;D009046;D012399 | T068;T023;T040;T169;T025 |
36,224,391 | global trend cropland phosphorus use sustain challeng meet grow food demand address multipl challeng exacerb phosphorus p pollut deplet p rock reserv p use effici pue ratio product p output p input defin system crop product need improv although mani effort devot improv nutrient manag practic farm studi examin histor trajectori pue socioeconom agronom driver nation scale present databas p budget input output crop product system pue countri crop type examin substanti contribut sever driver pue econom develop stage crop portfolio address p manag challeng found global pue crop product must increas recent trend indic meaning progress toward goal howev p manag challeng opportun cropland vari wide among countri | D000069599;D018556;D010758;D000076502 | T068;T002;T090;T078;T196;T197;T067 |
36,224,389 | global hotspot soil natur conserv soil foundat terrestri ecosystem howev unlik plant anim global assess hotspot soil natur conserv still lack hamper abil establish natur conserv prioriti multipl dimens support soil system soil biodivers ecosystem servic identifi global hotspot soil natur conserv perform global field survey includ observ biodivers archaea bacteria fungi protist invertebr function critic six ecosystem servic composit sampl topsoil standard survey contin found differ ecolog dimens soil speci rich alpha divers measur amplicon sequenc variant communiti dissimilar ecosystem servic peak contrast region planet associ differ environment factor temper ecosystem show highest speci rich wherea communiti dissimilar peak tropic colder high latitudin ecosystem identifi hotspot ecosystem servic find highlight complex involv simultan protect multipl ecolog dimens soil show hotspot adequ cover protect area vulner context sever scenario global chang global estim prioriti soil natur conserv highlight import account multidimension soil biodivers ecosystem servic conserv soil futur generat | D044822;D003247;D012987;D012988;D062305 | T064;T167;T081;T069;T078;T170;T062;T067;T080 |
36,224,387 | function base typolog earth ecosystem unit nation develop post global biodivers framework convent biolog divers attent focus new goal target ecosystem conserv might serv vision live harmoni natur advanc dual imper conserv biodivers sustain ecosystem servic requir reliabl resili general predict ecosystem respons environment chang manag ecosystem vari biota servic provis relat exposur risk yet global consist classif ecosystem reflect function respons chang manag hamper progress develop conserv target sustain goal present intern union conserv natur iucn global ecosystem typolog conceptu robust scalabl spatial explicit approach general predict function biota risk manag remedi across entir biospher outcom major cross disciplinari collabor novel framework place earth ecosystem unifi theoret context guid transform ecosystem polici manag global local scale new inform infrastructur support knowledg transfer ecosystem specif manag restor global standard ecosystem risk assess natur capit account progress post global biodivers framework | D003247;D017753;D058735 | T064;T081;T082;T069;T078;T070 |
36,224,386 | structur omega nickas isrb complex rna target dna rna guid system crispr cas combin programm substrat recognit enzymat function combin use advantag develop power molecular technolog structur studi system illumin rna protein joint recogn cleav substrat guid ration engin technolog develop recent work identifi new class rna guid system term omega includ iscb like ancestor cas nickas isrb homologu iscb lack hnh nucleas domain isrb consist around amino acid small size counterbalanc relat larg rna guid rough nt rna report cryogen electron microscopi structur desulfovirgula thermocuniculi isrb dtisrb complex cognat rna target dna find overal structur isrb protein share common scaffold cas contrast cas howev use recognit rec lobe facilit target select isrb reli rna part form intric ternari structur posit analog rec structur analys isrb rna well comparison rna guid system highlight function interplay protein rna advanc understand biolog evolut divers system | D003850;D004247;D017394 | T116;T121;T126;T123;T114 |
36,224,385 | activ globin express hypoxia induc factor around birth globin express human red blood cell rbcs shift globin globin result fetal haemoglobin hbf gradual replac adult haemoglobin hba process motiv develop innov approach treat sickl cell diseas thalassaemia increas hbf level postnat rbcs provid therapeut relev insight globin gene switch obtain crispr cas screen ubiquitin proteasom compon regul hbf express rbc precursor deplet von hippel lindau vhl e ubiquitin ligas stabil ubiquitin target hypoxia induc factor hif induc globin gene transcript mechanist hif hif heterodim bound cognat dna element bglt long noncod rna gene locat kb downstream tandem globin gene hbg hbg follow recruit transcript activ chromatin open increas long rang interact globin gene upstream enhanc similar induct hbf occur hypoxia inhibit prolyl hydroxylas domain enzym target hif ubiquitin vhl e ubiquitin ligas find link globin gene regul canon hypoxia adapt provid mechan hbf induct stress erythropoiesi suggest new therapeut approach haemoglobinopathi | D055545 | T123;T116 |
36,224,384 | structur tmc complex illumin mechanosensori transduct initi step sensori transduct pathway underpin hear balanc mammal involv convers forc gate mechanosensori transduct channel despit profound socioeconom impact hear disord fundament biolog signific understand mechanosensori transduct composit structur mechan mechanosensori transduct complex remain poor character report singl particl cryo electron microscopi structur nativ transmembran channel like protein tmc mechanosensori transduct complex isol caenorhabd elegan two fold symmetr complex compos two copi pore form tmc subunit calcium bind protein calm transmembran inner ear protein tmie calm make extens contact cytoplasm face tmc subunit wherea singl pass tmie subunit resid peripheri complex pois like handl accordion subset complex addit includ singl arrestin like protein arrestin domain protein arrd bound calm subunit singl particl reconstruct molecular dynam simul show mechanosensori transduct complex deform membran bilay suggest crucial role lipid protein interact mechan mechan forc transduc ion channel gate | D017173;D020285;D007473;D040542 | T116;T059;T123;T044;T204 |
36,224,382 | identif analysi dysregul fatti acid metabol gene breast cancer subtyp breast cancer one aggress lethal type transform among women anomali normal fatti acid metabol acknowledg critic trigger malign transform includ breast cancer prospect target fatti acid metabol treatment malign remain unrecogn far observ specif fatti acid metabol gene involv commenc develop breast cancer specif gene also observ relat differ isotypesmolecular subtyp breast cancer main purpos studi scrutin prognost signific function role express pattern fatti acid metabol gene silico tool like tcga brca gepia ualcan analysi ucsc xena kaplan meier plotter bc gene exmin string gene ontolog kegg databas use assess express pattern fatti acid metabol gene breast cancer patient also among differ molecular sub type breast cancer differenti gene express analysi reveal dysregul fabp fabp plin plin plin plin lpin mgll pnpla pnpla acsl acox show fold chang also gene show downregul ualcan analysi differ isotypesmolecular subtyp breast cancer studi reveal screen gene ie fabp fabp plin plin plin plin lpin mgll pnpla pnpla acsl acox use biomark reveal poor prognosi may serv therapeut target treatment breast cancer | D001943 | T191 |
36,224,381 | experi love protect covid pandem chang peopl percept urban suburban green space conserv target public green open space fulfil various social ecolog econom aesthet role complementari also compet one anoth covid pandem catalys multipl societ chang includ citizen percept need expect relat urban green space articl discuss extent tempor geograph chang pattern experienc natur space also influenc user percept behaviour well appreci conserv area studi base upon two survey carri greater metropolitan region vienna capit citi austria quantit survey repres onlin panel among viennes popul n well qualit interview expert respons conserv area administr feder park along ngos repres carri spring summer studi show chang percept urban citizen toward green space covid pandem increas import time spent natur possibl visit larg green area report viennes citizen also higher recognit green space locat close home observ among respond signific differ opinion green area pandem various age gender group thus present studi contribut ongo intern discuss transit societ need effect urban green space induc pandem present result highlight need urgent transform toward sustain resili healthi urban space graphic abstract | D000086382;D000068316 | T083;T047;T067 |
36,224,378 | global situ analysi structur proteom individu parkinson diseas identifi new class biomark parkinson diseas pd preval neurodegen diseas robust biomark need protein structur reflect function test whether global situ analysi protein structur chang provid insight pd pathophysiolog could inform new concept structur diseas biomark use limit proteolysi mass spectrometri lip ms identifi structur alter protein cerebrospin fluid csf individu pd relat healthi donor protein enrich process misregul pd protein also show structur chang pd brain sampl csf protein structur inform outperform abund inform discrimin healthi particip pd improv discriminatori perform csf measur hallmark pd protein synuclein also present first analysi inter individu variabl structur proteom healthi individu identifi biophys featur variabl protein region although independ valid need data suggest global analys human structur proteom guid develop novel structur biomark diseas enabl hypothesi generat under diseas process | D019636;D010300 | T047 |
36,224,376 | isatropoloneisarubrolon c streptomyc biolog activ induc incomplet autophagi isatropolonesisarubrolon streptomyc secondari metabolit featur tropolon ring pentacycl scaffold molecul abl induc complet autophagi human hepg cell methyl isatropolon isarubrolon identifi streptomyc cpcc methyl tropolon ring pentacycl scaffold molecul resolv ms nmr spectra biolog activ assay indic isatropolon c isarubrolon c induc incomplet autophagi human hepg cell | D013302 | T007 |
36,224,357 | feasibl studi use sodium algin inject penetr abdomin trauma swine model penetr abdomin injuri major caus death trauma sodium algin hydrogel hemostat agent offer platform target mechan biolog injuri current studi assess effect low viscos high g vlvg algin follow abdomin trauma swine model penetr abdomin injuri seven anesthet pig instrument invas monitor cathet abdomin trauma introduc laparoscop hepatectomi ten minut induct hypovolem shock three anim intra abdomin administ vlvg algin studi group four anim salin control group h continu monitor various hemodynam biochem variabl measur liver biopsi histolog evalu taken hemodynam vlvg algin treat anim stabl control reflect lower heart rate higher blood pressur p also lower level liver enzym lactat less histopatholog damag show vlvg algin might promis new agent reduc penetr intra abdomin injuri hemostat biocompat effici tissu preserv properti futur effort integr dispers devic may turn valuabl pre hospit emerg tool improv surviv trauma casualti | D000007;D006490;D014950 | T121;T037 |
36,224,354 | mass spectrometri imag discrimin glioblastoma tumor cell subpopul differ microvascular format base lipid profil glioblastoma preval malign brain tumor despit clinic intervent tumor recurr frequent usual fatal genom investig provid greater understand molecular heterogen glioblastoma yet still curat treatment prognosi remain unchang aggress natur glioblastoma attribut heterogen tumor cell subpopul aberr microvascular prolifer gangliosid direct immunotherapi membran lipid therapi shown efficaci treatment glioblastoma truli har novel therapeut develop regimen improv clinic outcom greater understand alter lipidom profil within glioblastoma tumor microenviron urgent need work high resolut mass spectrometri imag util investig lipid heterogen human glioblastoma sampl data present offer first insight histolog specif accumul lipid involv cell metabol signal cardiolipin phosphatidylinositol ceramid phosphat gangliosid includ glioblastoma stem cell marker gd shown differenti accumul tumor endotheli cell subpopul convers reduct sphingomyelin sulfatid detect tumor cell region cellular accumul lipid class depend upon fatti acid residu composit highlight import understand lipid structur function relationship discrimin ion identifi correl histopatholog ki prolifer index result identifi multipl lipid within glioblastoma microenviron warrant investig develop predict biomark lipid base therapeut | D001932;D005909 | T191 |
36,224,353 | extend machin learn techniqu polycyst ovari syndrom detect use ovari ultrasound imag polycyst ovari syndrom pcos preval endocrinolog abnorm one primari caus anovulatori infertil women global detect multipl cyst use ovari ultrasonograpgi usg scan one reliabl approach make accur diagnosi pcos creat appropri treatment plan heal patient syndrom instead depend error prone manual identif intellig comput aid cyst detect system viabl approach therefor research extend machin learn classif techniqu pcos predict propos train test ovari usg imag convolut neural network cnn incorpor differ state art techniqu transfer learn employ featur extract imag stack ensembl machin learn techniqu use convent model base learner bag boost ensembl model meta learner use reduc featur set classifi pcos non pcos ovari propos techniqu signific enhanc accuraci also reduc train execut time compar exist ml base techniqu follow propos extend techniqu best perform result obtain incorpor vggnet pre train model cnn architectur featur extractor stack ensembl model meta learner xgboost model imag classifi accuraci classif | D007247;D010053;D011085 | T047;T046;T023;T033 |
36,224,351 | structur analysi overoxid cuzn superoxid dismutas ros induc al filament format eukaryot cu zn superoxid dismutas sod primarili respons cytotox filament format amyotroph later sclerosi al neuron two cystein residu sod form intramolecular disulfid bond studi aim explor molecular mechan sod filament format cystein overoxid sporad al sal studi determin crystal structur doubl mutant cdcd sod mimic overoxid disulfid form cystein residu structur reveal open relax conform loop iv contain mutat asp doubl mutant sod produc contagi filament wild type protein promot filament format wild type sod protein import found hocl treatment wild type sod protein facilit filament format propos feasibl mechan sod filament format al wild type sod suggest overoxid sod trigger factor sal find extend understand neurodegen disord associ ros stress molecular level | D000690 | T047 |
36,224,350 | characterist drug relat problem pharmacist intervent hospit patient thailand prospect observ studi drug relat problem drps major health concern better understand characterist drps throughout hospit stay may help tailor pharmaceut care servic pcs studi aim describ characterist drps compar drp pattern differ stage hospit stay drps identifi clinic pharmacist part routin servic pharmacist assess causal sever prevent drp total prevent drps occur patient median rang drps per patient drps occur discharg stage frequent caus drp drug treatment spite exist indic account drps drug treatment exist indic detect frequent discharg compar stage p valu common intervent physician start drug accept rate drps hospit patient occur stage hospit stay systemat identif drp characterist enabl pharmacist tailor optim type pcs requir henc improv patient safeti | D064420;D010595 | T097;T046;T037 |
36,224,348 | parasitolog malacolog survey identifi transmiss site schistosoma mansoni gomma district south western ethiopia schistosomiasi neglect tropic diseas disproportion affect poorest peopl tropic subtrop countri major parasit diseas caus consider morbid ethiopia despit signific control effort schistosomiasi transmiss still widespread mani rural area countri aim studi determin preval intens intestin schistosomiasi among schoolchildren well identifi schistosomiasi transmiss site gomma district southwestern ethiopia octob septemb cross section parasitolog malacolog survey conduct studi area studi compris school children age year old four primari school gomma district identifi quantifi egg schistosoma mansoni children stool specimen collect process use doubl kato katz thick smear water bodi adjac human settlement studi area survey snail intermedi host mansoni morpholog identif collect snail conduct follow examin infect status use dissect microscop overal preval mansoni infect ci moder heavi infect preval mansoni infect differ consider age group older age group higher preval younger age group p preval infect also vari signific among school dedo urech highest preval p goga kilol relat lowest preval mansoni infect p total biomphalaria pfeifferi snail collect survey site throughout studi area snail shed schistosom cercaria despit intensifi effort scale mass drug administr ethiopia studi report high level mansoni infect among schoolchildren snail intermedi host rural communiti gomma high infect rate warrant press need target integr intervent control diseas area | D012550;D012555 | T047;T204 |
36,224,347 | clinic molecular find three japanes patient n acetylneuramin acid synthetas congenit disord glycosyl nan cdg report clinic molecular find three japanes patient n acetylneuramin acid synthetas congenit disord glycosyl nan cdg patient exhibit uniqu constel clinic featur includ mark hydrocephalus spondyloepimetaphys dysplasia semd thrombocytopenia compar infant report fay peterson et al wherea patient show camera geneviev type smed intellectualdevelopment disabl current known sole diseas name nan cdg molecular studi reveal matern inherit like pathogen cdel p argserf variant patern deriv like pathogen cdup p iledup variant patient homozyg like pathogen cdup p iledup variant caus matern segment isodisomi involv nan patient patern inherit pathogen c variant lead aberr splice matern inherit like pathogen ct c p tyrhi variant patient refer mrna nm result togeth previous report data impli nan play import role postnat growth fetal brain develop smed recogniz birth show remark postnat evolut nan cdg associ low normal serum sialic acid obvious elev urin n acetylmannosamin normal n glycosyl serum protein nan cdg divid camera geneviev type sever fay peterson type | D018981;D019158 | T047;T109;T123 |
36,224,346 | setppa signal regul macrophag posit hypox tumor region amplifi chemotact respons tumor associ macrophag tam one main cellular compon tumor microenviron tme mani type solid tumor tam tend accumul hypox area intim relat poor patient prognosi howev under mechan tam infiltr hypox tumor region remain unclear studi report genet delet se transloc set myeloid cell inhibit entri tam hypox tumor region abat proangiogen immunosuppress function ultim inhibit tumor growth mechanist respons hypox tumor supernat stimul set macrophag shuttl nucleus cytoplasm via pkc ck signal axi cytoplasm retent set increas erk p signal inhibit ppa promot tam migrat hypox area polar toward phenotyp therefor conclud set modul tumor immun act key regul macrophag posit function tumor | D008264;D059016 | T025;T070 |
36,224,345 | role ripk necroptosi cell signal diseas receptor interact protein kinas ripk rip essenti protein program regul cell death pathway call necroptosi necroptosi activ death receptor ligand pattern recognit receptor innat immun system find mani report suggest necroptosi high signific health human diseas signific larg necroptosi distinguish mode cell death especi apoptosi high proinflammatori given cell membran integr lost trigger activ immun system inflamm discuss role ripk cell signal along role necroptosi various pathway trigger ripk activ cell death last consid patholog situat ripknecroptosi may play role | D000079302;D017209 | T043;T123;T116 |
36,224,344 | circular rna crebbp modul cartilag degrad activ smad pathway tgfalk axi osteoarthr character articular cartilag degrad lead caus chronic disabl older adult studi indic circular rnas crucial regul chondrocyt develop involv progress osteoarthr studi investig function mechan circular rna potenti osteoarthr therapi express level circcrebbp screen circular rna sequenc chondrogen differenti adipos tissu deriv stem cell tgf signific increas cartilag patient osteoarthr il induc chondrocyt circcrebbp knockdown increas anabol extracellular matrix inhibit chondrocyt degener wherea circcrebbp overexpress led opposit effect luciferas report assay rescu experi rna immunoprecipit rna pulldown assay confirm circcrebbp upregul tgf express spong mir result signific enhanc phosphoryl smad chondrocyt moreov intra articular inject adeno associ virus sh circcrebbp allevi osteoarthr mous model destabil medial meniscus find reveal critic role circcrebbp progress osteoarthr provid potenti target osteoarthr therapi | D002358;D035683;D010003 | T047;T024;T123;T114 |
36,224,343 | molecular target therapi anticanc treatment sinc initi clinic approv late remark anticanc effect certain type cancer molecular target therapi util small molecul agent therapeut monoclon antibodi act signal transduct inhibitor serv fundament backbon precis medicin cancer treatment approach use clinic first line therapi various type human cancer compar convent chemotherapi target therapeut agent effici anticanc effect fewer side effect howev emerg drug resist major drawback molecular target therapi sever strategi attempt improv therapeut efficaci overcom resist herein summar current knowledg regard sever target therapeut agent includ classif brief biolog target kinas mechan action exampl clinic use target therapi perspect futur develop | D000970;D009369 | T121;T109;T191 |
36,224,340 | infant expect agent minim collect cost collabor action paper argu human infant address challeng optim recogn interpret collabor behavior assess collect effici hypothesi test use look time studi fourteen month old n familiar agent perform collabor action comput anim test phase look time measur agent act various effici paramet critic condit agent action individu effici combin either collect effici ineffici infant look longer test event violat expect collect effici p thus preverb infant appli expect collect effici action involv multipl agent | D002657 | T040;T039 |
36,224,339 | psd anterior cingul cortex contribut neuropath pain interdepend activ nrb studi suggest scaffold protein postsynapt densiti protein psd involv multipl neurolog dysfunct howev role psd anterior cingul cortex acc neuropath pain np investig current studi address role psd acc np modul profil nmda receptor subunit b nrb np model establish chronic constrict injuri cci sciatic nerv mechan thermal test use evalu behavior hyperalgesia protein express distribut evalu use immunohistochemistri western blot result show psd nrb co local neuron acc cci psd nrb upregul acc inhibit nrb ro attenu pain hypersensit decreas express psd induc cci furthermor intra acc administr psd antisens oligonucleotid attenu pain hypersensit also downregul nrb level phosphoryl cyclic amp respons element bind protein result demonstr psd acc contribut np interdepend activ nrb | D009437 | T047;T184 |
36,224,338 | older barbari macaqu show limit capac self regul avoid hazard social interact accord strength vulner integr savi model older peopl motiv avoid negat affect high arous younger peopl explor biolog root effect investig communic interact social inform process barbari macaqu macaca sylvanus live la fort des sing rocamadour franc studi combin analysi product n signal signal respons communic signal n event receiv field experi n trial subject show older monkey like specif ignor negat social inform employ avoid strategi stress situat although overal less sociabl suggest monkey limit capac self regul within social interact rather reli general avoid strategi decreas risk potenti hazard social interact | D000068356;D000083505 | T055;T054;T033 |
36,224,337 | elev serum plasminogen activ inhibitor predict postop delirium independ neural damag sequenti analysi older adult surgic patient suscept develop delirium earli intervent initi potenti biomark associ delirium identifi acut phase surgeri therefor investig chang level serum inflammatori mediat respons delirium serum biomark measur preoper postop day patient underw esophag cancer surgeri compar patient develop delirium serum concentr brain deriv phosphoryl neurofila heavi subunit remain higher level throughout entir periop period patient delirium n without delirium n interact delirium non delirium signific plasminogen activ inhibitor includ age covari f p p observ power periop period plasminogen activ inhibitor level discrimin patient without clinic diagnos delirium signific high accuraci area curv sensit negat predict valu p rapid increas level serum plasminogen activ inhibitor may enabl clinician identifi patient risk develop postop delirium initi earli prevent intervent | D003693;D020196 | T037;T048 |
36,224,335 | alter brain microstructur mous model prenat opioid exposur detect diffus mri grow opioid use among pregnant women fuel crisi infant born prenat opioid exposur larg bodi research devot studi manag opioid withdraw neonat period infant less substant work explor long term impact prenat opioid exposur neurodevelop use translate relev mous model prenat methadon exposur pme aim studi investig cerebr microstructur differ mice pme prenat salin exposur pse brain eight week old male offspr either pme n pse n imag use high resolut vivo diffus magnet reson imag tesla small anim scanner brain microstructur character use diffus tensor imag dti bingham neurit orient dispers densiti imag bingham noddi voxel base analysi vba perform use calcul microstructur parametr map vba show signific p bilater alter fraction anisotropi fa mean diffus md axial diffus ad radial diffus rd orient dispers index odi dispers anisotropi index dai across sever cortic subcort region compar pse particular pme offspr fa md ad signific higher hippocampus dorsal amygdala thalamus septal nuclei dorsal striatum nucleus accumben dti base result suggest widespread bilater microstructur alter across cortic subcort region pme offspr consist observ dti bingham noddi deriv odi exhibit signific reduct pme offspr within hippocampus dorsal striatum cortex noddi base result suggest reduct dendrit arbor pme offspr across multipl cortic subcort region best knowledg first studi prenat opioid exposur examin microstructur organ vivo find demonstr perturb microstructur complex cortic subcort region persist earli adulthood could interfer critic neurodevelopment process individu prenat opioid exposur | D056324;D066127 | T023;T060;T024 |
36,224,334 | identif hub gene candid herbal treatment obes integr bioinformat analysi revers network pharmacolog obes global epidem elev risk various metabol disord lack effect drug treat obes combin bioinformat revers network pharmacolog studi identifi effect herb treat obes identifi differenti express gene deg adipos tissu weight loss analyz five express profil gse gse gse gse gse gene express omnibus geo databas identifi hub gene protein protein interact ppi network perform mcode use search tool retriev interact gene string databas gene ontolog go kyoto encyclopedia gene genom kegg pathway enrich analys reveal hub gene role extracellular matrix receptor interact cholesterol metabol pik akt signal pathway etc ten herb alo portulaca herba mori follum silybum marianum phyllanthi fructus pollen typha ginkgo semen leonuri herba eriobotrya folium litsea fructus target nine hub gene cola mmp mmp spp dnmtb mmp cetp cola muc use six ingredi identifi key herb quercetin epigallocatechin gallat determin key ingredi last ingredi target herb ingredi target herb tast meridian tropism network construct use cytoscap elucid complex relationship studi could help identifi promis therapeut target drug treat obes | D019295;D020778 | T091;T126;T116 |
36,224,333 | sex differ innat inflammatori respons macrophag polar streptococcus agalactia induc pneumonia potenti role microrna p number studi shown biolog sex risk factor incid sever infect induc inflammatori diseas under mechan still poor understood studi compar innat inflammatori respons male femal mice group b streptococc gbs induc pneumonia although male femal mice display similar bacteri burden male exhibit innat inflammatori cytokin chemokin higher proport infiltr monocytesmacrophag analysi distribut macrophag subtyp pro inflammatori versus anti inflammatori yield higher mm ratio infect male compar femal given import chromosom x link microrna p mir p modul inflammatori process macrophag polar investig potenti contribut sex bias gbs induc innat inflammatori respons knock mir p specif antagomir result increas inflammatori respons higher mm ratio follow gbs infect notabl compar male mice detect higher amount mir p macrophag femal correl negat phenotyp result suggest differenti express mir p may impact macrophag polar therebi contribut fine tune sex differ inflammatori respons | D035683;D011014 | T050;T047;T123;T114 |
36,224,332 | snp allel call illumina infinium omni data use butterfli method introduc within sampl snp call method call butterfli method improv qualiti snp call illumina infinium omni snp kit done improv call determin allel signal intens high confid snp allel call extrem import forens genet clinic diagnost paper accompani two open sourc r packag omnimanifest snpbeadchip make snp call easi help bookkeep give easi access meta inform snps type illumina infinium omni kit includ chromosom probe type snp base compar result method obtain illumina genomestudio softwar provid sampl snp specif genotyp probabl qualiti measur whole genom sequenc wgs given signal intens snp call qualiti optimis use threshold posteriori probabl snp belong snp cluster lower posteriori probabl threshold call obtain higher call rate genomestudio use higher posteriori probabl threshold achiev higher concord wgs data genomestudio method snp call concord rate wgs data approxim | D020641 | T086 |
36,224,331 | virtual data augment method reaction predict improv perform data driven reaction predict model propos intellig strategi predict reaction product use avail data increas sampl size use fake data augment research fake data set creat augment raw data construct virtual train model fake reaction dataset creat replac function group ie data analysi strategi fake data compound modifi function group increas amount data reaction predict approach test five differ reaction result show improv relev techniqu increas model predict furthermor evalu method differ model confirm general virtual data augment summari virtual data augment use effect measur solv problem insuffici data signific improv perform reaction predict | D012107 | T081;T170;T169;T062;T096 |
36,224,329 | disturb microbi skin recolon cutan immun respons follow allogen stem cell transfer composit gut microbiom influenc clinic cours allogen hematopoiet stem cell transplant hsct littl known relev skin microorgan singl center observ studi recruit cohort patient undergo condit treatment took stool skin sampl one year hsct could confirm intestin dysbiosi follow hsct report skin microbiom likewis perturb hsct recipi overal bacteri colon skin decreas condit particular patient develop acut skin graft versus host diseas agvhd present overabund staphylococcus spp addit loss alpha divers indic agvhd develop alreadi diseas onset correl diseas sever co local cd leukocyt staphylococci observ skin agvhd patient even diseas develop parallel upregul gene requir antigen present mononuclear phagocyt overal data reveal disturb skin microbiom well cutan immun respons hsct recipi chang associ cutan agvhd | D018380;D006086;D000069196 | T007;T061;T047;T001 |
36,224,328 | opinion analysi aspect understand covid pandem use bert bi lstm ensembl method social media platform signific increas general inform diseas sever inform prevent measur among communiti member identifi public opinion tweet subject covid investig public sentiment countri period articl propos novel method sentiment analysi coronavirus relat tweet use bidirect encod represent transform bert bi direct long short term memori bi lstm ensembl learn model propos approach consist two stage first stage bert model gain domain knowledg covid data fine tune sentiment word dictionari second stage bi lstm model use process data bi direct way context sequenc depend preserv process data classifi sentiment final ensembl techniqu combin model classifi sentiment posit negat categori result obtain propos method better state art method moreov propos model effici understand public opinion twitter platform aid formul monitor regul public health polici pandem | D000086382;D061108 | T047;T170;T067 |
36,224,327 | vitro inhibit sar cov infect dri alga powder chlorella spp spirulina spp fucoidan dri powder commerci food supplement consid safe human consumpt broad spectrum antivir properti studi howev effect sar cov remain unknown investig potenti antivir activ three alga powder chlorella vulgari arthrospira maxima spirulina fucoidan purifi marin brown alga sargassum spp sar cov infect vitro vero cell incub gml alga powder either tcid ml sar cov two type experi pretreat simultan compar two kind solvent dmem dmso chlorella vulgari powder inhibit sar cov infect assay viral rna signific reduc supernat h post infect highest differ viral load fold observ h arthrospira maxima powder inhibit sar cov infect use tcid ml experiment scheme protect percent lower viral inoculum increas tcid ml viral rna decreas h infect reach fold differ h fucoidan powder partial inhibit sar cov infect sinc cpe observ trate cultur dmem antivir activ increas protect dmso use solvent alga sampl show high antivir activ sar cov si result suggest three alga sampl potenti therapeut candid treatment covid | D000086382;D048408 | T047;T067;T002 |
36,224,325 | effect trimetazidin patient chronic heart failur stratifi express solubl suppress tumorigen sst prospect cohort studi trimetazidin report potenti benefit patient chronic heart failur chf solubl suppress tumorigen sst shown worsen chf henc diagnost valu heart failur aim present studi evalu effect trimetazidin patient express high low level sst compar match placebo | D014292;D006333 | T121;T047;T109;T046 |
36,224,319 | risk factor globe remov open globe injuri agricultur region studi aim identifi preval risk factor globe remov among patient open globe injuri ogi agricultur region retrospect chart review patient ogi perform januari decemb univari multivari logist regress model use identifi factor associ globe remov ogi studi includ patient eye highest preval ogi observ middl age group year common caus ogi agricultur relat injuri follow industri workplac relat injuri assault intraocular foreign bodi endophthalm panophthalm report case respect eight eviscer enucl perform account ogi common indic globe remov panophthalm multivari analysi reveal predict factor signific associ globe remov assault injuri adjust odd ratio aor p present logarithm minimum angl resolut visual acuiti aor p endophthalm panophthalm aor respect p knowledg would aid patient counsel encourag health promot | D009877;D015807;D010202 | T047;T037 |
36,224,315 | ultrasensit colorimetr detect fluorid arsenat water mammalian cell use recycl metal oxacalixaren probe later flow assay global billion peopl consum water moder high concentr fluorid arsenic develop simpl point care poc devic home devic detect fluoridearsen ensur safeti consum water till date later flow assay lfa base poc devic detect nucleic acid virus diseas aluminium complex rhodamin b function oxacalix aren l design execut lfa base poc devic initi al fe ion involv complex rhodamin b function oxacalix aren l result c l al c l fe complex respect receptor l well probe c c character thorough use mass spectroscopi ftir nmr ea c c util recycl probe detect aqueous fluorid ppb arsenat ppb respect comput calcul indic upon complex spirolactam ring open rhodamin b site lead optoelectron chang consist lfa base portabl sens devic test water sampl synthet fluorid standard dental care product like toothpast mouthwash concentr ppm moreov fix cell imag experi perform ascertain vitro sens phenomena | D001151;D009696 | T131;T121;T196;T123;T114 |
36,224,313 | nt exert antineoplast activ target jnk axl signal lung cancer cell combin therapi multi target drug point option prevent emerg resist clone could make long term treatment effect translat better clinic outcom cancer patient nt compound synthet tyrphostin lead long term inhibit igfrir stat axl mediat signal pathway given import signal pathway develop progress lung cancer diseas becom interest model generat preclin evid cellular molecular mechan under antineoplast activ nt lung cancer cell exposur nt decreas dose depend manner cell viabil clonogen cell cycl progress migrat induc apoptosi p molecular scenario nt reduc express ir axl phosphoryl p mapk akt ebp besid nt decreas express oncogen bcl ccnd myb myc increas gene relat cellular stress apoptosi jun bbc cdkna cdknb fos egr p favor tumor suppress cell signal network context lung cancer note jnk identifi key kinas nt induc ir ir phosphoryl reveal novel axi involv mechan action drug nt also present potenti effect egfr inhibitor lung cancer cell conclus preclin find highlight nt putat prototyp multitarget drug may contribut antineoplast arsenal lung cancer | D000970;D008175 | T121;T109;T191 |
36,224,312 | anophel gambia sl swarm trap complementari tool residu malaria transmiss eastern gambia malaria remain major health problem vector control essenti approach decreas burden although threaten insecticid resist new approach vector control need femal anophel gambia sl mate life swarm form male trap swarm anophel gambia sl male potenti new intervent vector control altern use insecticid would disrupt mate proof concept pilot studi aim investig swarm trap potenti vector control intervent carri villag eastern gambia swarm anophel gambia sl identifi size height durat determin baselin year swarm trap local volunt implement follow transmiss season villag villag taken control entomolog outcom monitor human land catch pyrethrum spray catch cross section survey determin malaria preval carri peak malaria transmiss season two consecut year baselin swarm site anophel gambia sl identifi intervent mean indoor rest densiti per hous malaria preval similar control intervent villag follow intervent anophel gambia sl indoor rest densiti lower intervent control villag adj irr ci odd malaria infect lower intervent control villag ci swarm trap seem promis communiti base vector control intervent could reduc malaria preval reduc vector densiti result investig confirm larger cluster random trial | D000852;D007306;D008288 | T047;T131;T204 |
36,224,309 | stannous colloid mix indocyanin green tracer sentinel lymph node navig surgeri combin use vital dye radioact colloid report perform better detect sentinel lymph node slns cancer use either alon howev especi gastric cancer two endoscop procedur requir administ two tracer burden patient practition propos use stannous colloid snc mix indocyanin green icg new mix tracer snc icg characterist investig vivo vitro estim use sln navig tracer administ rat accumul radioact andor near infrar fluoresc evalu region lymph node lns use singl positron emiss comput tomographi near infrar fluoresc imag respect snc icg show signific better clearanc inject site better migrat primari lns singl administr snc icg aqueous solut snc icg demonstr wide particl size variabl stabil nm upon addit albumin vitro properti could contribut behavior vivo use snc icg could contribut better perform detect slns gastric cancer less burden patient medic practition | D000072281;D000071036;D013274 | T191;T047;T023 |
36,224,308 | predict persist acut kidney injuri postop intens care unit patient use integr machin learn retrospect cohort studi acut kidney injuri aki often occur patient intens care unit icu aki durat close relat prognosi critic ill patient identifi diseas cours length aki critic develop effect individualis treatment predict persist aki earli stage base machin learn algorithm integr model overal patient admit icu surgeri complic aki retrospect evalu occurr persist aki predict use three machin learn method support vector machin svm decis tree extrem gradient boost integr model extern valid also perform incid persist aki intern valid svm exhibit highest area receiv oper characterist curv auc valu follow integr model extern valid auc valu svm integr model respect model calibr chart reveal model good perform critic ill patient aki surgeri high incid persist aki machin learn model could effect predict occurr persist aki earli stage | D058186;D016638 | T047;T037 |
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