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36,224,693
clinic characterist nontubercul mycobacterium infect case sichuan china retrospect studi studi distribut nontubercul mycobacterium ntm strain clinic characterist drug sensit data ntm infect provid support prevent treatment diseas caus ntm infect sichuan
D008171;D009165
T047
36,224,692
effect dose prophylact norepinephrin prevent hypotens combin spinal epidur anesthesia cesarean section singleton versus twin pregnanc determin compar effect dose ed prophylact infus norepinephrin prevent hypotens combin spinal epidur anesthesia cesarean section singleton versus twin pregnanc
D000767;D000775;D006973;D007022
T061;T047;T033
36,224,691
effect social support multimorbid relat outcom middl age older adult china analyz current status social support middl age older adult multimorbid explor correl differ dimens social support multimorbid relat outcom basi china health retir longitudin studi charl survey data reveal complex social background multimorbid impact social support multimorbid
D000076322;D012944
T078;T054
36,224,690
effect famili function suicid relat behavior junior middl school student mediat effect depress examin preval suicid relat behavior among junior middl school student explor mediat role depress relationship suicid relat behavior famili function
D003863;D012309
T055;T184;T048
36,224,689
correl gut microbiota chang cognit function patient post stroke cognit impair earli stage observ chang composit gut microbiota stroke patient show cognit impair within one month stroke explor correl bacteria present dissimilar cognit function clinic indic
D060825;D000069196;D020521
T007;T001;T047;T048
36,224,688
genet subtyp status transmit drug resist hivaid patient sichuan investig distribut characterist hiv genet subtyp status quo transmit drug resist among hivaid patient sichuan previous histori receiv antiretrovir therapi art
D000163;D015658;D015497
T047;T005
36,224,687
salivari metabol profil patient periodont analyz salivari metabol profil patient periodont metabolom techniqu explor metabol pattern associ periodont diseas
D005891;D010510;D010518
T047
36,224,686
bifidobacterium bifidum tmc promot earli life intestin microbiota build allevi symptom inflammatori bowel diseas investig effect use bifidobacterium bifidum tmc earli life intestin microbiota immun function long term impact inflammatori bowel diseas
D000069985;D003092;D000069196;D015212
T007;T001;T047
36,224,685
effect mycobacterium tuberculosi higba bacteri stress respons intracellular infect immun investig effect mycobacterium tuberculosi mtb higba bacteri stress respons intracellular infect immun
D009169
T007
36,224,684
pulmonari vascular remodel characterist pulmonari arteri hypertens mous model induc left pneumonectomi jugular vein inject monocrotalin pyrrol compar investig differ characterist pulmonari vascular remodel three mous model pulmonari arteri hypertens pah construct left pneumonectomi jugular vein inject monocrotalin pyrrol left pneumonectomi combin jugular vein inject monocrotalin pyrrol explor pah anim model approxim clinic pathogenesi pah creat model provid sound basi thorough investig pathogenesi sever pah
D006976;D000081029
T047;T046
36,224,683
effect bone marrow mesenchym stem cell mechan dynam balpctx express rat osteoporot vertebr fractur analyz effect bone marrow mesenchyml stem cell bmscs bone alkalin phosphatas balp c termin telopeptid type collagen ctx express mechan dynam rat osteoporot op vertebr fractur
D024042;D059630;D010446;D016103
T025;T123;T116;T037
36,224,682
hadha inhibit migrat invas htr svneo cell regul pikakt signal pathway explor effect hydroxyacyl coa dehydrogenas alpha subunit hadha migrat invas htr svneo cell human trophoblast cell line potenti mechan action
D011225;D051057
T046;T126;T116
36,224,681
hydrogen sulfid amelior myocardi injuri caus sepsi suppress ros mediat endoplasm reticulum stress investig effect hydrogen sulfid h reactiv oxygen speci ros mediat endoplasm reticulum stress myocardi injuri caus sepsi
D006862;D018805
T047;T046;T131;T130;T197
36,224,680
vcr small molecul compound induc reprogram rat fibroblast neural progenitor cell hypox condit explor protocol reprogram rat embryon fibroblast ref hypox condit form chemic induc rat neural progenitor cell cirnpc
D058953;D014635
T121;T025;T109
36,224,679
big data manag applic specialti construct overview explor personnel train system medic school focus undergradu specialti construct big data manag applic medic colleg univers context new medic educ first analyz paper demand train personnel special status program construct nation region level take anhui medic univers exampl key medic univers anhui provinc introduc prepar made medic colleg univers set big data manag applic specialti final perspect object personnel train curriculum system practic teach system present detail exploratori effort made anhui medic univers construct train system personnel special big data manag applic paper report main work done explor personnel train curriculum system cover general educ profession educ extracurricular activ highlight interdisciplinari characterist personnel train curricular system integr medicin engin manag also report practic teach system combin class practic teach extracurricular activ incorpor tier content increas challeng basic practic level cognit practic level comprehens practic level innov practic level studi expect provid use refer train personnel special medic big data context new medic educ
D000079803;D012577
T093;T057;T073;T062
36,224,678
clinic analysi abo incompat live donor liver transplant children evalu safeti clinic efficaci abo incompat live donor liver transplant ldlt children
D016031;D019520
T098;T061
36,224,677
relationship level anatom risk hepat alveolar echinococcosi complic radic resect analyz impact high low level anatom risk hepat alveolar echinococcosi hae complic radic resect
D004444;D010996
T047
36,224,676
applic tghdl c combin liver function index predict metabol associ fatti liver diseas studi applic triglycerid high densiti lipoprotein cholesterol ratio tghdl c combin liver function index predict metabol associ fatti liver diseas mafld
D001786;D008107
T047;T109;T033
36,224,675
assess valu short term prognosi six predict model patient acut chronic liver failur treat artifici liver support system appli predict model acut chronic liver failur aclf patient treat artifici liver support system alss compar assess valu short term prognosi patient
D065290;D058625;D019164
T047;T074
36,224,674
fucoidan modifi phase transit contrast agent ultrasound imag target hepatoma cell prepar fucoidan modifi phase transit contrast agent fpca evalu vitro capabl ultrasound imag target hepatoma cell
D006528;D008113;D053758
T191;T073
36,224,673
mechan mirna inhibit downstream zadh target gene promot hepatocellular carcinoma cell prolifer examin relationship mirna hepatocellular carcinoma hcc cell line verifi downstream target gene mirna
D006528;D008113;D035683
T191;T123;T114
36,224,672
applic diffus weight imag hepatobiliari specif contrast agent gd eob dtpa diagnosi differenti diagnosi focal liver lesion mani type focal liver lesion fll present differ lesion sign diagnosi differenti diagnosi relat difficult great clinic signific accur detect classifi character focal liver lesion soon possibl diffus weight imag dwi provid inform liver cell densiti microstructur microcircul perfus gadolinium ethoxibenzyl diethylenetriamin pentaacet acid gd eob dtpa hepatobiliari specif contrast agent gd eob dtpa enhanc mri examin liver provid inform blood perfus lesion specif inform uptak function normal liver cell combin applic two signific improv sensit diagnost accuraci detect fll herein review research find applic dwi gd eob dtpa fll diagnosi order provid refer clinic applic exist studi made comparison discuss dwi imag qualiti differ b valu fit appar diffus coeffici adc valu gd eob dtpa enhanc report find vari also inconsist whether gd eob dtpa affect dwi imag still debat futur research focus quantit comparison discuss verif enhanc effect inject gd eob dtpa well chang adc valu correspond differ b valu enhanc order provid object consist research result clinic applic
D003287;D008113
T191;T130
36,224,668
macular telangiectasia bilater obliter capillari case report report otherwis healthi adult macular telangiectasia aneurysm ischemia obliter capillari eye
D003930;D013684
T047;T033
36,224,664
effect internet base counsel cognit behaviour approach premenstru syndrom assess effect internet base counsel cognit behaviour approach symptom sever women premenstru syndrom pms qualiti life perimenstru late follicular phase menstrual cycl moreov pms relat disabl attitud toward menstruat investig secondari outcom
D011293;D011788
T078;T047
36,224,663
chicken mir p negat regul antivir innat immun target traf innat immun play essenti role prevent invas pathogen microorgan howev innat immun doubl edg sword whose excess activ detriment immun homeostasi even lead cytokin storm infect host host develop seri negat regulatori mechan balanc immun respons report negat regulatori mechan chicken innat immun mediat mirna geo databas found mir p mark regul chicken infect rna virus upregul mir p rna virus shown via cell model vivo test overexpress mir p signific inhibit express interferon inflammatori cytokin relat gene induc rna virus opposit result achiev knockdown mir p express bioinformat analysi identifi traf candid target gene mir p experiment mir p target traf shown effect mir p endogen express traf traf utr driven luciferas report assay furthermor demonstr mir p negat regul innat immun block mav traf tbk axi co express assay overal result suggest mir p involv negat regul chicken innat immun might contribut maintain immun balanc
D035683;D048008
T123;T116;T114
36,224,662
later shift femor condyl total knee arthroplasti simul use templat medial pivot design knee radiograph young japanes patient total knee arthroplasti tka establish surgic treatment advanc knee osteoarthr patient expect improv knee pain function although mani surgeon investig limb align tka chang coron posit relat femur tibia known well
D019645;D020370
T061;T047
36,224,661
accuraci next generat sequenc molecular profil small specimen lung cancer prospect pilot studi side side comparison success practic precis medicin advanc lung cancer reli therapeut regimen tailor individu molecular characterist aim studi investig accuraci small specimen molecular profil use next generat sequenc ngs
D060890;D008175
T191;T116;T129
36,224,660
low cost genom workflow enabl isol screen strain level analys within microbiom earth environ harbor complex consortia microb affect process rang host health biogeochem cycl understand evolut function limit inabl isol genom high throughput manner present workflow bacteri whole genom sequenc use open sourc labwar opentron robot platform reduc cost approxim per genom assess genom divers within gut bacteri speci wild live chimpanze bonobo quantifi intraspecif genom divers reveal diverg homolog plasmid host enabl popul genet analys bacteri strain current possibl metagenom data alon
D016680;D064307
T001;T032;T028
36,224,659
quantit measur resist forc subsequ attenu passiv isokinet extens wrist patient mild moder spastic stroke spastic evalu measur increas resist passiv movement primarili manual method option avail measur spastic wrist object furthermor studi investig forc attenu follow increas resist aim studi conduct safe quantit evalu wrist passiv extens stiff stroke survivor mild moder spastic paresi use custom motor control devic furthermor want clarifi whether chang measur valu could quantit reflect spastic state flexor muscl involv wrist stiff patient
D020521;D000071939
T061;T047
36,224,656
barrier recommend cervic cancer screen program among women low resourc set lago nigeria qualit studi cervic cancer fourth common cancer women global despit larg treatabl prevent malign develop countri account new case women resid low resourc set resid slum higher risk cervic cancer lower uptak cervic cancer screen divers barrier influenc uptak cervic cancer screen among women low resourc set
D002583
T191
36,224,655
malaria outbreak facilit increas mosquito breed site near hous cessat indoor residu spray kole district uganda januari june june surveil data uganda district health inform system reveal outbreak malaria kole district analysi reveal case exceed outbreak threshold januari ministri health deploy team investig area peopl affect identifi risk factor diseas transmiss recommend control prevent measur
D000852;D004196;D008288
T047;T067;T204
36,224,654
preval predictor advanc direct among termin ill patient taiwan enact patient right autonomi act nationwid popul base studi sign advanc direct ad ensur termin ill patient receiv end life care accord wish therebi promot human digniti spare unnecessari suffer despit enact hospic palliat care act taiwan complet rate ad found low among patient chronic ill condit date limit exist research avail regard factor associ ad complet termin ill patient taiwan explor sign ad characterist compar differ sign ad patient without cancer examin factor associ sign ad termin ill patient
D009369;D019452
T191;T101
36,224,651
unifi global genotyp framework dengu virus serotyp stratifi coordin surveil strategi dengu epidem dengu fastest spread arbovir diseas pose great challeng global public health reproduc compar global genotyp framework contextu spatiotempor epidemiolog data dengu virus denv essenti research studi collabor surveil
D003715;D003716;D058872
T067;T047;T005
36,224,650
import role nlrp inflammasom pasteurella multocida infect pasteurella multocida p multocida caus sever respiratori diseas cattl result high mortal morbid inflammasom multiprotein complex cytoplasm recogn pathogen play import role host defens microbi infect studi mechan p multocida induc nlrp inflammasom activ investig vitro vivo first p multocida induc sever inflamm larg number inflammatori cell infiltr lung wt nlrp mice nlrp mice suscept p multocida infect bacteri burden lung recruit macrophag neutrophil lung investig result show number immun cell signific decreas nlrp mice subsequ nlrp shown regul p multocida induc inflammatori cytokin secret includ il il vivo vitro tnf secret alter moreov nlrp found mediat caspas activ asc oligomer result il secret furthermor nlrp inflammasom mediat gene express chemokin includ cxcl cxcl cxcr drive activ nlrp inflammasom final nlrp protein express detect abrog p multocida infect nlrp macrophag indic synerg effect nlrp nlrp studi demonstr nlrp inflammasom play import role host p multocida infect contribut develop immun therapeut p multocida
D058847;D016979
T007;T123;T116
36,224,645
person pancreat cancer therapi perspect mrna vaccin pancreat cancer character inter tumor intra tumor heterogen especi genet alter microenviron convent therapeut strategi pancreat cancer usual suffer resist highlight necess person precis treatment cancer vaccin becom promis altern pancreat cancer treatment multifacet advantag includ multipl target minim nonspecif effect broad therapeut window low toxic induct persist immunolog memori multipl convent vaccin base cell microorgan exosom protein peptid dna pancreat cancer develop howev overal efficaci remain unsatisfactori compar vaccin modal messag rna mrna base vaccin offer technic concept advanc person precis treatment thus repres potenti cut edg option novel therapeut approach pancreat cancer review summar current progress pancreat cancer vaccin highlight superior mrna vaccin convent vaccin propos viabl tactic design appli person mrna vaccin precis treatment pancreat cancer
D019496;D010190
T121;T191;T116;T129
36,224,644
pacadi translat adapt swedish languag version pancreat cancer diseas impact score norwegian pancreat cancer diseas impact score pacadi digit analogu questionnair assess differ diseas specif symptom need translat languag therefor aim articl describ translat process swedish version pacadi present valid eorct qlq pan self administ questionnair pacadi translat accord guidelin assess expert panel health care personnel test valid perform diseas specif questionnair eorct qlq pan questionnair complet subject pancreat cancer either discharg three month surgeri
D007802;D010190
T191;T171
36,224,642
surfac fungal divers sever mycotoxin relat gene express profil lunar palac experi chines lunar palac lp ground base bio regen life support system blss test bed integr high effici plant cultiv anim protein product urin nitrogen recycl bioconvers solid wast date molecular method base detail investig fungal communiti mycotoxin potenti blss habitat ensur safe blss design actual space mission analyz lp surfac mycobiom mycotoxin potenti lunar palac project intern transcrib spacer region amplicon sequenc quantit polymeras chain reaction qpcr primer specif idh ver tri
D000072761;D009183
T109;T131;T004
36,224,641
effect intermitt fast bodi composit nutrit intak among employe obes jakarta random clinic trial studi aim determin effect intermitt fast bodi composit employe obes jakarta
D002149;D005215
T055;T081;T033
36,224,640
correl insulin base c peptid base homeostat model assess insulin resist adult without diabet sub saharan african set cross section studi assess correl insulin base c peptid base homa ir general popul without diabet sub saharan africa well identifi factor associ ir
D003924;D007333
T047;T046
36,224,639
crisprca mediat delet interleukin suppress igf cxcl boost soc reduc prostat cancer growth mortal metastat prostat cancer pc lead caus cancer death men worldwid target culprit diseas progress unmet need interleukin il promot pc onset develop whether suitabl therapeut target remain investig shed light relationship il canon pc driver gene explor anti tumor potenti crisprca mediat delet il
D060890;D011471
T191;T116;T129
36,224,636
clinic analysi acromi height measur devic combin new type clavicular hook plate standard clavicular hook plate treatment neer type ii distal clavicl fractur distal clavicular fractur shoulder joint injuri common clinic set general surgic treat use clavicular hook plate techniqu confirm curat effect howev symptom shoulder abduct limit shoulder discomfort postop joint pain may occur patient overcom problem previous studi develop acromi height measur devic new type clavicular hook plate studi aim investig whether acromi height measur devic combin improv new type clavicular hook plate better reduc incid complic improv postop function provid patient better treatment effect acromion gaug clavicular hook plate use
D050723;D019534
T047;T037
36,224,635
molecular characterist coxsackievirus strain zhejiang china enterovirus ev enterovirus ev general caus hand foot mouth diseas hfmd howev limit studi focus uncommon enterovirus serotyp coxsackievirus cv studi aim provid evid determin molecular characterist cv strain isol zhejiang provinc china
D004770;D029821;D004769;D006232
T047;T005
36,224,631
anti mllerian hormon independ affect mtdna copi number human granulosa cell recent delay childbear trend emerg modern women adulthood diminish reproduct potenti due age relat chang preval reduct abund mitochondri dna mtdna copi circul anti mllerian hormon amh separ report age contribut decreas success reproduct howev limit report impact age mtdna amh individu whether mtdna copi number influenc age amh
D054304;D004272
T116;T121;T123;T114;T125
36,224,627
delay puberti gonadotropin abnorm subfertil male padipadi doubl knockout mice peptidylarginin deiminas enzym pad convert arginin residu citrullin process call citrullin deimin recent two pad pad pad link hormon signal vitro goal studi test link padpad hormon signal vivo
D002956;D007246
T046;T116;T121;T123;T033
36,224,625
identif human mhc hpv ee specif cd cell epitop generat hpv ee express adenosquam carcinoma hla transgen mice human papillomavirus type hpv high risk hpv common associ cervic cancer hpv oncogen e e associ malign transform cell thus identif human leukocyt antigen hla restrict ee peptid specif cd cell epitop creation hpv ee express cervicovagin tumor hla transgen mice signific vaccin develop
D018196;D009856;D030361;D019444
T047;T116;T191;T121;T123;T114;T129
36,224,622
detect sar cov dog hemorrhag diarrhea sever acut respiratori syndrom coronavirus sar cov causat agent covid infect sever anim speci includ dog presum via human anim transmiss infect dog report asymptomat low viral load howev case detect sar cov dog north african coastal spanish citi ceuta present hemorrhag diarrhea diseas also report earlier infect dog usa
D000086382;D004283
T047;T067
36,224,621
implant adipos deriv mesenchym stem cell sheet promot axon regener restor bladder function spinal cord injuri cell base therapi use adipos deriv mesenchym stem cell adsc promis treatment strategi neurogen bladder nb associ spinal cord injuri sci howev therapeut efficaci low ineffici cell deliveri cell sheet improv efficaci cell transplant therefor studi conduct investig therapeut efficaci transplant adsc sheet sci rat model focus function patholog chang bladder
D059630;D013119
T025;T037
36,224,619
develop co design behaviour chang intervent aim healthcar profession recruit clinic trial matern care evid strategi improv recruit clinic trial matern care lack trial recruit matern healthcar profession mhcps perform behaviour eg talk trial potenti particip distribut trial inform may ordinarili outsid trial trial recruit intervent provid theoret basi potenti effect behaviour describ stakehold involv develop studi aim use behaviour theori co design process develop intervent mhcps task approach elig potenti particip invit join matern trial assess accept feasibl intervent
D008427
T058
36,224,618
digit adapt teach disast deploy medicin covid condit compar evalu year covid pandem brought mani aspect disast medicin everyday awar also led massiv chang medic teach due necess contact restrict studi aim evalu student accept curricular elect modul disast deploy medicin year period present content adjust due covid restrict
D000086382;D004190;D004504;D013337
T047;T097;T067;T065
36,224,617
follow strategi patient splenic trauma manag non oper world societi emerg surgeri consensus document world societi emerg surgeri publish guidelin manag adult pediatr patient splenic trauma sever issu regard follow patient splenic injuri treat nom remain unsolv
D000007;D014949
T037
36,224,614
immunotheranost microbubbl imb modular platform dendrit cell vaccin deliveri appli breast cancer immunotherapi therapeut strategi engag immun system malign cell revolution field oncolog profici dendrit cell dcs antigen present immun respons spur interest dc base vaccin anti cancer therapi howev despit favor safeti profil patient current dc vaccin yet present signific outcom due technic barrier activ dc deliveri tumor progress immun dysfunct maxim therapeut respons present uniqu cell free dc base vaccin capabl lymphoid organ target elicit cell mediat anti tumor effect
D001943;D019496
T191;T121;T116;T129
36,224,613
spectct imag featur cystic degener talus relat patholog find osteochondr lesion talus olt common orthoped condit imag present similar ischem necrosi talus complic talar neck fractur two differ lesion abnorm bone densiti signal talar bodi apex fornix concomit bone defect cystic chang found x ray comput tomographi ct magnet reson imag import accur determin natur lesion make correct diagnosi treatment prognosi patient purpos studi explor imag featur three phase singl photon emiss comput tomographi spect ct imag cystic lesion talus
D003560;D013628
T023;T190
36,224,611
block px intracerebroventricular inject px specif nanobodi reduc stroke lesion previous studi demonstr purinerg receptor could therapeut target modul inflammatori respons multipl model brain diseas howev tool select effici target receptor lack develop new px specif nanobodi nbs enabl us effect block px channel
D018048;D061905;D020521
T129;T047;T116;T192
36,224,610
sustain threshold health outcom health expenditur educ nexus select african countri quadrat moder model studi align sustain develop goal border good health well peopl ensur healthi live promot well age contribut health literatur evalu role health expenditur educ qualiti three health outcom infant mortal matern mortal life expect birth
D005102;D008017
T068;T081;T102
36,224,608
epitop vaccin design toxoplasma gondii base genom wide databas membran protein present effect safe vaccin toxoplasma gondii human studi describ design search novel group optim b cell cell epitop toxoplasma membran protein use genom wide comprehens screen
D014122;D014612
T129;T121;T116;T204
36,224,607
baicalin act adjuv potenti activ azithromycin staphylococcus saprophyticus biofilm vitro vivo molecular studi staphylococcus saprophyticus frequent involv various difficult treat infect due format biofilm identifi use antibiofilm strategi studi explor efficaci mechan baicalin enhanc abil azithromycin multidrug resist staphylococcus saprophyticus liu liyang china francolin mdrss biofilm vitro vivo azithromycin use combin baicalin minimum inhibitori concentr biofilm micb azithromycin decreas fold compar azithromycin baicalin group combin azithromycin baicalin could reduc biofilm biomass dispers rate biofilm decreas bactericid abil increas furthermor relat transcript level walkr system relat gene upregul addit baicalin azithromycin plus baicalin compar azithromycin blank control group strong correl relationship walkr system bactericid index demonstr baicalin enhanc bactericid effect azithromycin mdrss biofilm modul walkr system mous cutan infect model combin azithromycin baicalin succeed erad mdrss decreas patholog injuri studi indic baicalin potenti adjuv enhanc antimicrobi activ azithromycin mdrss biofilm form modul walkr system
D017963;D055624
T007;T109;T195
36,224,605
modifi non modifi risk factor dementia midlif cerebr small vessel diseas cognit healthi middl age adult prevent dementia studi consider overlap exist risk factor dementia cerebr small vessel diseas svd howev studi remain limit older cohort wherein patholog dementia eg amyloid svd eg white matter hyperintens alreadi co exist younger asymptomat adult investig differenti associ interact modifi non modifi inherit risk factor futur late life dementia present day mid life svd
D016657;D059345;D003704;D006973
T047;T048
36,224,603
neoadjuv toripalimab combin gemcitabin cisplatin resect local advanc head neck squamous cell carcinoma neotgp open label singl arm phase ib clinic trial neoadjuv program death receptor pd inhibitor drawn increas attent local advanc head neck squamous cell carcinoma hnscc studi investig safeti efficaci gemcitabin cisplatin gp combin pd inhibitor patient local advanc hnscc
D000971;D006258;D000077195
T191;T061
36,224,602
earli onset immun mediat diseas minor ethnic group uk preval immun mediat diseas imd show distinct differ popul differ ethnic aim studi determin age diagnosi common imd also differ differ ethnic group uk suggest distinct influenc ethnic diseas pathogenesi
D005006;D044465
T098;T102
36,224,601
transcriptom profil sporad alzheim diseas patient alzheim diseas ad manifest age common refer earli onset ad eoad reitz et al neurol genet e major eoad case caus autosom domin mutat psen psen app higher herit sporad late onset ad load wingo et al arch neurol fulton howard et al neurobiol age e e although endpoint clinicopatholog chang ie plaqu tau tangl cognit declin common across eoad load diseas progress high heterogen neff et al sci adv assoc adv sci eabb heterogen lead tempor distinct age onset aao stage cognit declin may caus myriad combin distinct diseas associ molecular mechan other use transcriptom profil ad patient deriv neuron model autosom domin eoad sporad load identifi diseas endotyp caldwel et al sci adv assoc adv sci eaba merten et al cell stem cell e caldwel et al alzheim demen analys larg postmortem brain cohort demonstr one third ad patient show hallmark diseas endotyp like increas inflamm decreas synapt signal neff et al sci adv assoc adv sci eabb area brain less affect ad patholog earli diseas stage primari visual cortex exhibit similar transcriptom dysregul region tradit affect therefor may offer view molecular mechan ad without associ inflammatori chang gliosi induc patholog haroutunian et al neurobiol age end analyz ad patient sampl primari visual cortex eoad load use transcriptom signatur identifi patient cluster diseas endotyp interest although cluster show distinct combin sever endotyp patient cluster contain eoad load case suggest aao may direct correl ident sever ad endotyp
D000544
T047;T048
36,224,600
clinic experiment studi terahertz time domain system determin patholog margin laryng carcinoma laryng cancer common malign otorhinolaryngolog head neck surgeri account approxim one third head neck malign terahertz time domain spectroscopi thz tds recent found use detect tumor studi conduct investig applic thz tds diagnosi patholog resect margin laryng cancer
D002277;D007822;D055068
T191;T059
36,224,599
develop core outcom set hypertens intracerebr hemorrhag clinic trial tradit chines medicin studi protocol intracerebr hemorrhag ich devast diseas mortal disabl rate high china hypertens intracerebr hemorrhag hich respons case primari ich lot random control trial rcts tradit chines medicin tcm treat hich carri howev rcts lot problem heterogen outcom non uniform point measur lead systemat reviewmeta analysi includ small number studi outcom measur take wish patient stakehold account aim studi establish core outcom set cos futur tcm clinic trial hich
D020299;D008516
T091;T046;T060
36,224,598
tumor necrosi factor inhibitor pediatr patient sapho syndrom associ acn conglobata synov acn pustulosi hyperostosi osteiti sapho syndrom rare chronic inflammatori diseas osteoarticular cutan involv main manifest acn conglobata sever acn form may affect adolesc patient tumor necrosi factor inhibitor usual use second line therapi refractori sapho syndrom report treat acn conglobata success herein report three case adolesc patient sapho syndrom associ acn conglobata success treat tnfi therapi
D000069316;D000152;D020083;D010000
T047
36,224,597
medic student medium term skill retent follow cardiac point care ultrasound train base american societi echocardiographi curriculum framework studi demonstr medium long term skill retent cardiac point care ultrasound pocus curriculum medic student base american societi echocardiographi ase curriculum framework develop blend learn cardiac pocus curriculum compet evalu object studi investig curriculum impact imag acquisit skill retent week initi train
D004452;D013337
T060;T097
36,224,596
bmsc exosom enrich acellular fish scale scaffold promot bone regener tissu engin scaffold essenti repair bone defect use biomimet scaffold bone tissu engin investig decad date trend area move toward construct biomimet acellular scaffold effect modif enhanc osteogen differenti effici bone marrow mesenchym stem cell bmscs exosom deriv bmscs shown potenti therapeut tool repair bone defect studi demonstr pro osteogen effect exosom deriv form osteogen differenti bmscs obmsc present novel exosm function decellular fish scale de fs scaffold promot bone regener vivo de fs scaffold obtain decellular decalcif process exhibit high biocompat low immunolog reject intrins anisotrop structur de fs could enhanc adhes prolifer abil bmscs vitro addit demonstr porous structur de fs endow capac load releas exosom bmscs result enhanc osteogen differenti bmscs concern pro osteogen effect prove obmsc exosom modifi de fs scaffold could effect promot bone regener mous calvari defect model conclus work provid new insight design exosom rich biomimet scaffold bone tissu engin clinic applic
D055354;D010012
T026;T042
36,224,595
function outcom predict model acut traumat spinal cord injuri base extrem gradient boost aim construct nonlinear regress model extrem gradient boost xgboost predict function outcom year surgic decompress patient acut spinal cord injuri sci explor import predictor predict function outcom
D013119;D013124
T037
36,224,594
transmiss pathogen canin hn influenza virus dog guinea pig model influenza virus caus respiratori diseas mani anim speci well human due high human anim interfac monitor canin influenza dog studi transmiss pathogen canin influenza anim import
D004283;D007251;D009976
T047
36,224,593
thymofibrolipoma case report review literatur thymofibrolipoma describ variant thymolipoma date case report lesion describ consist extens area collagen tissu interspers island matur adipos tissu strand thymic tissu
D008067;D008479;D013953
T191
36,224,592
identif action taken manag facilit return work cancer survivor consensus manag cancer survivor manag consid main stakehold return work rtw cancer survivor howev perspect cancer survivor manag differ manageri action taken rtw cancer survivor differ might put effect collabor success rtw risk therefor studi aim reach consensus among manag cancer survivor manageri action taken four differ rtw phase cancer survivor ie disclosur treatment rtw plan actual rtw
D000073116;D009369
T191;T101;T201
36,224,591
reduc activ parvalbumin posit interneuron posterior pariet cortex caus visual domin multisensori decis freeli navig mice multisensori integr vital anim make optim decis complic sensori environ howev neural mechan flexibl multisensori behavior well understood found mice exhibit auditori domin decis head fix stationari state switch make visual domin decis freeli navig state resolv audiovisu conflict understand neural mechan state depend switch multisensori decis perform vivo calcium imag parvalbumin express pv inhibitori neuron posterior pariet cortex ppc known mediat auditori domin resolut audiovisu conflict mice treadmil stationari state ppc pv neuron show similar amount evok activ respons auditori visual stimuli enhanc respons multisensori audiovisu stimuli convers mice run treadmil pv neuron lost auditori respons show multisensori enhanc activ optogenet activ ppc pv neuron mice freeli navig maze mice made auditori domin decis without chang unisensori decis data demonstr ppc pv neuron lost abil integr auditori inform visual one activ navig modul ppc pv neuron activ critic anim make adapt multisensori decis accord behavior state
D002118;D010320
T121;T123;T116;T196
36,224,590
sustain seroposit month covid studi evalu persist igm iga igg sar cov spike nucleocapsid antigen day sinc onset symptom longitudin cohort primari health care worker barcelona spain follow sinc start pandem studi also assess factor affect antibodi level includ comorbid respons variant concern well frequenc reinfect despit gradual signific declin antibodi level time seroposit five sar cov antigen combin alway higher whole studi period subset particip yet vaccin novemb seroposit remain igm iga igg igg seroposit alpha delta predomin variant compar wuhan variant lower gamma beta minor variant iga igm antibodi level time point closest infect associ age smoke obes hospit fever anosmiahypogeusia chest pain hypertens multivari regress model year later massiv roll vaccin antibodi level associ age occup hospit durat symptom anosmiahypogeusia fever headach addit tachycardia cutan symptom associ slower antibodi decay oxygen suppli faster antibodi decay eight reinfect detect low respond consist sustain protect role anti spike natur acquir antibodi stabl persist igg iga respons cross recognit predomin variant circul period indic long last larg variant transcend humor immun initi month pandem absenc vaccin
D000370;D000086382
T047;T048;T184;T067;T033
36,224,589
preponder vaccin prevent diseas hotspot northern ghana spatial space time cluster analysi vaccin prevent diseas vpds persist global disproportion high burden low middl incom countri lmic although might part due failur sustain vaccin coverag region nuanc understand vpd transmiss beyond vaccin coverag may unveil import factor vpd transmiss control studi identifi vpds hotspot explor relationship ecolog urban land use variat artisan small scale gold mine asgm activ ghana
D009107;D013742;D000079263
T047
36,224,588
two circppfia negat regul liver metastasi colon cancer via mir pcdx hurrab circular rnas circrna play critic role colorect cancer crc progress includ metastasi howev detail molecular mechan fulli understood
D003110;D015179;D008113;D035683
T191;T123;T114
36,224,587
effect earli rhythm control improv clinic outcom patient atrial fibril systemat review meta analysi current guidelin recommend rhythm control improv symptom qualiti life symptomat patient atrial fibril af howev long term prognost outcom rhythm control compar rate control still inconclus meta analysi aim assess effect earli rhythm control compar rate control clinic outcom newli diagnos af patient
D001281;D006333;D020521
T047;T046
36,224,586
ayurved formul guduchi madhuyashti trigger jnk signal mediat immun respons advers affect huntington phenotyp huntington diseas manifest due abnorm cag trinucleotid expans first exon huntingtin gene diseas progress involv genet immun environment compon pathogenesi character format inclus bodi disrupt neuron circuitri cellular machineri apoptosi result gradual progress loss neuron cell ultim lead nervous system dysfunct thus present studi conduct assess effect two ayurved formul guduchi madhuyashti huntington phenotyp use drosophila model system
D020935;D016328
T044;T116;T129
36,224,585
choic refer chart affect strength associ malaria pregnanc small gestat age individu particip data meta analysi compar intergrowth tanzanian birthweight chart preval small gestat age sga may vari depend chosen weight gestat age refer chart individu particip data meta analysi conduct assess implic use local refer stoppam instead univers refer intergrowth associ malaria pregnanc sga
D007236;D008288
T047;T033
36,224,583
optim implement particip collect mail base sar cov serolog survey univers affili popul lesson learn practic guidanc rapid spread sar cov larg driven pre symptomat mild symptomat individu transmit virus serolog test identifi antibodi sar cov import tool character subclin infect exposuredur summer mail base serolog survey self collect dri blood spot dbs sampl implement among univers affili household member massachusett usa describ challeng face novel procedur use implement studi assess preval sar cov antibodi amid pandemicimport challeng includ user friend remot contact minim particip recruit limit avail commod laboratori capac potenti bias sampl popul polici chang impact distribut clinic result studi particip method lesson learn surmount challeng present inform design implement similar sero studiesthi studi design highlight feasibl accept self collect bio sampl broad applic serolog survey rang pathogen key lesson relat dbs sampl suppli requir logist pack ship packag data linkag enrol household member util call nurs avail particip concern sampl collect futur research might consid addit recruit techniqu conduct studi academ semest recruit univers set partnership suppli ship specialist use stratifi sampl approach minim potenti bias recruit
D000086382;D000086402
T047;T067;T005
36,224,582
enhanc mitochondri dna edit mice use nuclear export tale link deaminas nucleas present two method enhanc effici mitochondri dna mtdna edit mice ddda deriv cytosin base editor ddcbes first fuse ddcbes nuclear export signal ddcbe nes avoid target c convers nuclear genom improv edit effici mtdna second mtdna target talen mitotalen co inject mous embryo cleav unedit mtdna generat mous model mga mutat mt nd gene associ mitochondri genet disord human mutant mice show hunch appear damag mitochondria kidney brown adipos tissu hippocamp atrophi result prematur death
D004272;D028361
T047;T123;T114
36,224,581
extract argentinian nativ plant revers fluconazol resist candida speci inhibit efflux transport mdr cdr develop multidrug resist mdr associ overexpress efflux transport mdr cdr candida speci imped antifung therapi urgent need novel agent abl inhibit function pump led us evalu properti extract obtain argentinian plant
D002175;D015725
T121;T109;T004
36,224,580
popul genom icefish reveal mechan glacier driven adapt radiat antarct notothenioid antarctica harbor bulk speci divers domin teleost fish subord notothenioidei howev forc shape evolut still debat
D046448;D010473
T013;T070
36,224,579
parent health profession footwear stakehold belief import differ featur young children footwear qualit studi small build pool evid impact footwear children function mean understand differ belief stakehold footwear key featur flexibl critic translat recommend support parent caregiv purchas footwear children therefor research aim describ differ stakehold health profession parent footwear industri repres describ import flexibl footwear featur young children
D005528;D012775
T023;T073
36,224,578
poor non poor gap five child nutrit case nepal use blinder oaxaca decomposit approach mani low middl incom countri lmic improv health indic past decad howev differenti outcom socioeconom group systemat analysi driver child nutrit gap non poor poor group polici relev nepal countri make progress toward univers health coverag uhc object paper estim mean height age z score haz gap five children belong non poor poor group divid gap compon endow coeffici interact identifi factor contribut compon
D002664;D011203
T098;T064;T040;T102
36,224,577
pre pandem socio econom status chang employ first lockdown health middl age peopl england longitudin studi covid pandem mark disrupt peopl live caus higher mortal morbid amongst individu poorer socio econom posit sep well recognis job loss negat impact health hypothesis health effect pandem middl age peopl might differ depend sep chang employ
D000086382;D058873
T047;T067
36,224,576
nsmce novel super enhanc regul gene link poor prognosi therapi resist breast cancer despit today advanc treatment cancer breast cancer relat mortal remain high part due lack effect target therapi breast tumor type respond standard treatment therefor identifi addit breast cancer molecular target urgent need super enhanc larg region open chromatin involv overactiv oncogen thus inhibit super enhanc becom focus clinic trial therapeut potenti aim identifi novel super enhanc dysregul gene high associ breast cancer patient poor prognosi negat respons treatment
D001943
T191
36,224,575
robot assist rehabilit balanc gait stroke patient roar studi protocol preliminari random control trial stroke incid increas age negat impact motor cognit perform qualiti life independ person famili lead number direct indirect cost motor recoveri essenti especi elder patient enabl patient independ activ daili live prevent fall sever studi shown robot train associ physic therapi influenc function motor outcom walk stroke improv endur walk strategi consid data previous studi patient need gait balanc control hypothes robot assist balanc treatment associ physic therapi may effect usual therapi perform physic therapist term improv static dynam balanc gait fatigu cognit perform
D065287;D020521;D000071939
T061;T047
36,224,574
impact interact multi media learn physician musculoskelet educ pilot studi aim educ studi investig use interact case base modul relat screen identif earli stage inflammatori arthriti onlin technolog olt paper pf format ident content
D001168;D007396;D009141;D010820
T022;T047;T097;T065
36,224,573
factor associ men health facil attend client caregiv malawi communiti repres survey men higher rate morbid mortal across near top ten caus mortal worldwid much dispar attribut men lower util routin health servic howev littl known men general healthcar util sub saharan africa
D017028;D008571
T098;T097;T099;T100
36,224,572
establish biped rat model lumbar facet joint osteoarthr use intraarticular inject urinari plasminogen activ previous studi demonstr inject upa lumbar facet joint lfj normal rat rat lfjoa anim model success establish howev evid intraarticular inject upa induc much serious osteoarthr biped rat biomechan much similar human normal rat investig whether intraarticular inject urinari plasminogen activ upa induc lfjoa low back pain symptom biped rat
D010003;D021801
T047;T030
36,224,571
antimalari potenti compound isol mammea siamensi ander flower vitro molecular dock studi emerg antimalari drug resist encourag search new antimalari agent mammea siamensi belong calophyllacea famili medicin plant use tradit thai prepar hexan dichloromethan extract plant found potent antimalari activ therefor studi aim isol activ compound siamensi flower evalu antimalari potenti interact plasmodium falciparum lactat dehydrogenas pfldh
D000962;D035264;D031252;D010936
T121;T123;T002
36,224,570
tcfsnaimir feedback loop promot hypertrophi ligamentum flavum hypertrophi ligamentum flavum hlf main caus lumbar spinal stenosi lss precis mechan hlf format fulli elucid emerg evid indic transcript factor tcf key downstream function molecul wnt catenin signal particip regul multipl biolog process howev role under mechan tcf hlf still unclear
D017843;D035683
T023;T123;T114
36,224,569
sexual dimorph molecular mechan insulin resist critic development window wistar rat insulin resist ir condit respons organ insulin impair ir earli marker metabol dysfunct howev ir also appear physiolog context critic development window molecular mechan physiolog ir larg unknown sex sexual dimorph insulin sensit observ sinc earli stage develop propos period acceler growth around wean postnat day p rat kinas sk overactiv induc impair insulin signal target organ work aim character ir p determin under mechan identifi whether sexual dimorph physiolog ir occur stage
D007333
T046
36,224,568
predict factor residu leg numb decompress surgeri lumbar degen diseas purpos studi evalu chang pattern leg numb ln lumbar decompress surgeri lds find predict factor affect recoveri numb
D013123;D013130
T061;T020
36,224,567
assess road critic loss healthcar access flood case cyclon idai mozambiqu abil disast respons prepared mitig effort assess loss physic access health facil identifi impact popul key reduc humanitarian consequ disast recent studi use either network raster base approach measur access respect travel time analysi compar raster network base approach build open data respect abil assess loss access due sever flood event analysi use open access data approach transfer flood prone site support decis maker prepar disast mitig prepared plan
D055867;D055868
T070
36,224,566
barrier facilit access hiv servic street involv youth canada kenya unicef estim mani million street involv youth siy global margin condit put siy higher risk hiv advers outcom hiv posit object analysi describ barrier facilit access hiv prevent test treatment servic phase implement studi evalu use peer navig increas access hiv servic
D015658
T047
36,224,565
shoulder pain shoulder disabl depress serial mediat stress health relat qualiti life among middl age women studi analyz mediat effect shoulder pain disabl depress relationship stress health relat qualiti life among middl age women use serial mediat model
D011788;D020069
T078;T184
36,224,564
structur determin tailor behavior health servic sexual gender minor unit state panel analysi research indic tailor program sexual gender minor sgm eg lesbian gay bisexu transgend queer peopl compar non tailor program effect reduc disproportion health burden sgm peopl experi relat general popul howev avail sgm tailor program often report inconsist across behavior health ie substanc use mental health facil unit state us
D000072339;D019966
T098;T048;T033
36,224,563
immers educ curriculum intracoronari optic coher tomographi imag analysi among nave reader optic coher tomographi oct intravascular imag modal analys coronari vessel imag interpret remain obstacl novic reader due technic artefact uncertainti tissu character despit expand clinic research role oct train effort exist absenc nation standard educ curriculum sought determin whether interact feedback base oct curriculum improv imag interpret among naiv reader
D003324;D041623
T047;T060
36,224,562
fuscircezhklf feedback loop contribut cxcr induc liver metastasi breast cancer enhanc epitheli mesenchym transit metastasi breast cancer caus major cancer relat death worldwid circrna associ tumorigenesi metastasi breast cancer accord recent research howev biolog mechan circrna liver metastat breast cancer remain ambigu yet
D008113;D035683
T191;T123;T114
36,224,561
gender differ health protect behaviour implic covid pandem taiwan popul base studi sever acut respiratori syndrom coronavirus sar cov infect produc sever symptom higher mortal men women role biolog sex immun respons sar cov believ explain sex dispar howev contribut gender factor influenc health protect behavior therefor health outcom remain poor explor
D000086382;D058873
T047;T067
36,224,560
analysi gene express level impact surviv cancer type patient identifi novel prognost marker suggest unexplor immunotherapi treatment option wide rang malign immunotherapi dramat improv cancer treatment inhibit activ specif cell receptor thus unleash host anti tumor respons howev engag three main immun checkpoint far identifi ctla pd pd l effect fraction patient therefor novel target must identifi test
D008545;D061026
T191;T192;T116;T129