PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,223,159 | clinic public health har best world sick health effect sustain collabor clinic public health profession lead improv individu popul health concept clinic public health promot collabor clinic medicin public health address complex real world health challeng commentari describ concept clinic public health type complex problem requir collabor individu popul health barrier toward applic clinic public health becom evid covid pandem | D000086382;D011634 | T047;T091;T067 |
36,223,158 | factor associ high health care spend among patient schizophrenia understand reason wide variat health care spend among patient schizophrenia may benefit develop intervent aim improv patient outcom health care spend effici aim studi determin factor associ high health care spend patient popul | D012559 | T048 |
36,223,142 | desorpt electrospray ionize mass spectrometri imag allow spatial local chang acetaminophen metabol liver intervent methylpyrazol acetaminophen apap overdos common caus acut liver failur us hepatotox initi reactiv metabolit induc characterist centrilobular necrosi clinic avail antidot n acetylcystein limit efficaci identifi methylpyrazol mp fomepizol strong altern therapeut option protect generat downstream effect cytotox reactiv metabolit clinic relev cblj mous model human howev despit region restrict necrosi apap earlier studi apap metabolit biofluid whole tissu homogen lack spatial inform need understand region specif consequ reactiv metabolit format apap overdos thus gain insight region variat apap metabol studi influenc mp establish desorpt electrospray ionize mass spectrometri imag desi msi platform generat ion imag apap metabolit ambient air without chemic label prior coat tissu reduc chemic interfer perturb small molecul tissu local spatial intens distribut oxid nonoxid apap metabolit determin mous liver section rang apap overdos import exclus differenti signal intens metabolit abund note tissu microenviron mp treatment substanti influenc topograph distribut | D000082;D056486 | T121;T047;T109;T037 |
36,223,141 | construct bioluminesc sensor label free templat free separ free sequenc independ detect cluster isol damag genom dna dna damag induc endogenousexogen factor may caus various diseas genom dna damag becom import biomark clinic diagnosi risk assess remain great challeng accur quantifi cluster isol damag random locat larg divers low abund herein demonstr develop bioluminesc sensor label free templat free separ free sequenc independ detect cluster isol damag genom dna base base excis repair ber pathway termin transferas tdt initi templat free isotherm cyclic amplif damag base cleav dna glycosylas generat new oh terminus subsequ tdt catalyz repeat incorpor dttps oh terminus produc poli structur hybrid signal probe form poli sequencesign probe duplex lambda exonucleas hydrolysi larg number adenosin monophosph amp molecul produc generat high bioluminesc signal cyclic interconvers amp adenosin triphosph atp amp presenc luciferin firefli luciferas moreov introduct ape induc cyclic cleavag signal amplif great improv detect sensit propos strategi detect cluster isol damag genom dna extrem high sensit excel specif even distinguish dna damag mixtur import detect cellular dna damag detect limit ng extend measur various dna damag integr appropri dna repair enzym | D049409;D045647 | T126;T116 |
36,223,139 | deep neck space infect extend mediastinum treat conserv deep neck space infect dnsis challeng diagnos manag femal ex smoker present difficulti breath chest pain initi treat exacerb emphysema intraven antibiot ear nose throat team later ask review patient left submandibular swell odynophagia ct neck perform day later due limit avail covid show extens retropharyng collect level vallecula carina normal dnsi extend mediastinum would requir prompt surgic manag howev patient clinic well imag abscess manag conserv intraven antibiot | D000086382;D008482 | T047;T067;T029 |
36,223,135 | small interf rnas contain dioxan morpholino deriv nucleotid analogu show improv target profil chiral depend vivo knock expand applic recent develop dioxan morpholino base nucleotid analogu seed region destabil properti small interf rnas sirna investig order improv potenti target profil purpos correspond adenosin analogu synthes two diastereomer seri build block autom oligonucleotid synthesi obtain nucleotid precursor integr posit sirna antisens strand target transthyretin messeng rna evalu melt temperatur reveal signific differ obtain duplex stabil two diastereomer seri influenc central scaffold small sirna contain novel nucleotid structur show improv target profil vitro compar parent sequenc common ome modifi adenosin posit contrast vivo potenc high depend chiral within six member nucleotid scaffold show high mrna downregul r r configur diastereom | D011228;D009711 | T123;T116;T114 |
36,223,130 | striatal reactiv emot reward relat approach avoid conflict behaviour alter adult anxieti depress previous report activ reward salienc execut control region function mri fmri use approach avoid conflict aac decis make task healthi adult investig anxieti depress disord relat differ neural respons aac inform understand treatment test hypothesi peopl anxieti depress alter neural activ aac | D003863;D012201 | T184;T048;T041 |
36,223,128 | threat evid base care teratogen medic state abort restrict medic news articl discuss abort ban could affect patient teratogen drug standard care | D000028;D019317;D013723 | T093;T046;T116;T061;T131;T081;T091;T033 |
36,223,127 | corneal neuro regen effect transcutan electr stimul rabbit lamellar keratectomi model studi aim evalu effect transcutan electr stimul tes corneal nerv regener rabbit injur superfici lamellar keratectomi slk | D065306;D004561 | T061;T037;T033 |
36,223,126 | associ ambulatori blood pressur factor intraocular pressur relat hour contact len sensor profil untreat glaucoma investig associ diurnal blood pressur bp factor intraocular pressur iop relat hour contact len sensor cls profil patient untreat glaucoma | D003261;D005901 | T047;T074 |
36,223,121 | tempor trend suicid method among adolesc us cross section studi evalu tempor trend suicid method among us adolesc variat sex race | D013405 | T033 |
36,223,120 | use cardiopulmonari exercis test evalu long covid symptom adult systemat review meta analysi reduc exercis capac common report among individu covid symptom month sar cov infect long covid lc cardiopulmonari exercis test cpet criterion standard measur exercis capac identifi pattern exert intoler | D000086382 | T047;T067 |
36,223,119 | sensit diagnost yield first sar cov nucleic acid amplif test perform patient present hospit earli accur diagnost test sar cov essenti initi appropri treatment infect control prevent measur among patient present hospit | D000086382;D000086402 | T047;T067;T005 |
36,223,118 | use retent video telephon person buprenorphin treatment opioid use disord covid pandem coronavirus diseas covid pandem prompt polici chang allow increas telehealth deliveri buprenorphin potenti lifesav medic opioid use disord oud unclear characterist patient access differ treatment modal person vs telehealth video vs telephon vari whether modal associ retent key indic care qualiti | D002047;D000086382;D009293 | T047;T121;T109;T048;T067 |
36,223,110 | spatial properti adapt induc distanc compress exposur dynam textur reduc perceiv separ object alter map physic relat environ neural represent investig spatial tune spatial frame refer aftereffect understand stage process adapt induc chang occur experi measur appar separ differ posit relat adapt area reveal strong tight tune compress effect next test spatial frame refer effect either introduc gaze shift adapt test phase experi decoupl spatial select adapt retinotop world center coordin experi result across two experi indic retinotop world center adapt effect occur independ spatial attent locat adaptor alon could account world center transfer observ retinotop adapt transfer world center coordin saccad experi final found aftereffect differ refer frame similar narrow spatial tune profil experi togeth result suggest neural represent local separ resid earli visual cortex also modul activ higher visual area | D012160;D014793 | T023;T029 |
36,223,109 | percept object motion self motion correl bias judgment head direct object motion studi investig relationship perceiv head direct perceiv motion independ move object self motion use dual task paradigm test whether object motion judgment show bias consist head percept across condit trial trial subject view simul self motion estim head direct experi walk toward target virtual realiti conflict physic visual cue experi self motion independ move object briefli appear vari horizont veloc observ judg whether object move leftward rightward experi head estim show expect center bias object motion judgment show correspond bias trial trial variat also correl trial rightward head bias object motion judgment consist rightward head vice versa experi estim relat weight visual physic cue control walk object motion judgment strong influenc nonvisu cue less weight object motion vs also trial trial correl bias walk direct object motion judgment result provid evid share mechan contribut head percept percept object motion | D007600;D009039 | T041 |
36,223,105 | longer term caus cardiovascular mortal intens blood pressur control secondari analysi random clinic trial systol blood pressur intervent trial sprint show intens blood pressur control reduc cardiovascular morbid mortal howev legaci effect intens treatment unknown | D000959;D006973 | T121;T047 |
36,223,102 | suprathreshold contrast percept alter long term adapt habitu optic blur investig whether visual experi habitu blur alter neural process suprathreshold contrast emmetrop high aberr eye | D007640 | T047 |
36,223,101 | hypoxia induc factor rod neuroprotect follow retin detach follow retin detach rd photoreceptor prs sustain hypox stress eventu die hypoxia induc factor hif play central role cellular adapt hypoxia purpos studi determin necess hif pr cell surviv rd | D051795;D012163 | T047;T123;T116 |
36,223,099 | cyano intermedi enabl rapid stereoretent access modifi remdesivir nucleosid biochem structur comput studi shown import remdesivir c substitu perturb sar cov rdrp action recogn pauciti method stereoselect instal substitu posit obstacl rigor explor sar mechan report util anomer pure cyano intermedi entri point chemic divers set substitut allow diversif obviat need tedious separ anomer mixtur | D000086402;D000086382 | T067;T047;T005 |
36,223,082 | opioid antagonist orvinol seri potenti revers agent opioid overdos opioid crisi continu claim mani live particular issu readi avail use whether intent accident fentanyl fentanyl analogu fentanyl potent longer act naloxon standard care overdos revers make especi dead consequ interest opioid revers agent better abl counter effect orvinol seri ligand known high affin bind opioid receptor often extend durat action general compound scaffold show agonist activ kappa mu opioid receptor diprenorphin unusu member seri antagonist mu partial agonist kappa opioid receptor studi orvinol antagonist design synthes show agonist activ vitro least good naloxon revers effect mu opioid receptor agonist vivo | D009292;D000083682 | T121;T037 |
36,223,077 | macrocycl triazolopeptoid promis class extend cyclic peptoid head tail cyclize linear oligoamid contain benzylaminomethyl h triazol yl acet acid monom afford novel class extend macrocycl peptoid identif conform solut cyclodim x ray crystal structur cyclic tetraamid report | D034444 | T116 |
36,223,027 | treatment pattern treatment satisfact among adult alopecia areata unit state alopecia areata aa autoimmun diseas character non scar hair loss involv scalp face andor bodi prior us food drug administr fda approv treatment aa avail usa exist treatment option limit efficaci durabl often associ side effect studi aim evalu current aa treatment pattern treatment satisfact report dermatologist | D000506 | T047 |
36,223,015 | review covid mena region environment concern machin learn applic coronavirus diseas covid delay global econom growth affect econom life global one hand numer element environ impact transmiss new coronavirus everi countri middl east north africa mena area differ popul densiti air qualiti contamin water land relat condit influenc coronavirus transmiss world health organ advoc fast evalu guid policymak time evid respond situat review make four uniqu contribut one mani data transmiss new coronavirus various sort set provid clear answer current disput virus transmiss review two highlight signific applic machin learn forecast diagnos sever acut respiratori syndrom coronavirus sar cov three insight provid time accur inform along compel suggest method direct investig four present studi provid decis maker communiti leader inform effect environment control covid dissemin | D000086382 | T047;T067 |
36,222,995 | cardiac respons tambaqui colossoma macropomum anaesthetis piper divaricatum essenti oil aim studi evalu electrocardiograph respons colossoma macropomum expos short term bath use essenti oil piper divaricatum eopd anaesthet like agent differ dose l l cardiac respons throughout exposur eopd monitor evalu mean heart rate hr durat amplitud qrs complex ventricular depolar q ventricular contract r r time two success qrs complex wave interv across dose mark depress hr main l l eopd mean amplitud record qrs complex q interv l l eopd indistinguish control could reinforc concentr suffici safe promot fast anaesthesia without affect cardiac function recoveri bradycardia durat r r interv qrs complex similar l l eopd howev q interv l l eopd reveal pronounc cardiac depress relat control fish expos l l eopd thus conclud l l eopd suffic induc fast deep safe anaesthesia tambaqui juvenil wherea concentr l l led greater depress cardiac function albeit show effect revers | D009822;D031701;D060125;D000777 | T002;T121;T109;T013;T039 |
36,222,962 | reactiv bind mode disulfiram metabolit deriv sar cov pl pro insight comput chemistri studi papain like proteas pl pro sar cov import target develop antivir covid safe drug disulfiram dsf present antivir activ inhibit pl pro vitro clinic trial studi indic promis anti covid drug work aim understand mechan pl pro inhibit dsf verifi dsf metabolit deriv could potenti inhibitor molecular dock dft admet techniqu appli carbamoyl activ site cystein residu dsf metabolit detc meso kinet thermodynam favor g g kcal mol respect result strong suggest sulfoxid metabolit dsf promis coval inhibitor pl pro test vitro vivo assay confirm antivir action | D000086382;D000086402 | T047;T067;T005 |
36,222,931 | molecular model potenti applic beryllium oxid nanotub deliveri hydroxyurea anticanc drug within work scrutin use beo nanotub beont nanocarri anticanc drug hydroxyurea hu densiti function theori dft calcul util function bxd basi set g base detail surfac analysi hu adsorb surfac nanotub differ orient also vibrat spectra exhibit imaginari frequenc show minimum energi relax structur maximum adsorpt energi minimum adsorpt energi strong physic adsorpt beont exhibit p type semiconduct characterist orient sinc receiv electron charg hu result demonstr possibl use beont promis carrier hu drug | D000970;D043942 | T121;T109;T073 |
36,222,930 | reduct sulphur dioxid emiss environ adsorpt enhanc hematit surfac top prioriti sustain develop goal improv qualiti environ better live sulphur dioxid consid hazard gase pollut environ harm well organ india alon account world emiss strict action requir reduc maximum level emiss atmospher improv total air qualiti reduc emiss effect studi hematit chemic activ use naoh c h oh help doubl bed adsorpt column adsorb properti hematit studi brunauer emmett teller isotherm reveal high surfac area g pore size nm high volum pore cm mg ftir confirm particul surfac adsorb adsorpt capac oper temperatur c optim chemic adsorpt found inlet concentr mg decreas adsorpt increas trace well adsorb adsorb result mass transfer zone freundlich adsorpt spectrum fit low concentr langmuir isotherm result indic environment emiss reduc chemic enhanc hematit | D004784;D013458 | T057;T131;T197 |
36,222,929 | antioxid potenti procyanidin b dft densiti function theori dock approach procyanidin b one natur dimer flavonoid establish great role antioxid activ current studi wish provid crucial inform antioxid action dft comput dock approach point thermodynam view mx g p level hat hydrogen atom transfer spl et sequenti proton loss electron transfer princip antioxid rout compound gas methanol respect oh group two phenyl ring molecul like best antirad site kinet interact hoo radic oh group phenyl ring also generat best g gibb free energi activ rate constant k antioxid action procyanidin b confirm chelat metal ion complex format cu lower bind energi stabl complex format zn dock studi reveal antioxid activ procyanidin b involv human tyrosinas enzym inhibit interact essenti residu focus oh group two phenyl ring | D000975;D011522 | T121;T123;T196;T044;T039 |
36,222,928 | battl btk mutant noncoval inhibitor overcom cys thr mutat waldenstrm macroglobulinemia therapi structur mechanist insight role fenebrutinib recent non coval bruton tyrosin kinas btk inhibitor fenebrutinib present therapeut option strong inhibitori efficaci singl cs doubl tscs btk variant treatment waldenstrm macroglobulinemia wm howev molecular event surround inhibit mechan toward variant remain unresolv herein employ silico method molecular dynam simul coupl bind free energi estim explor mechanist activ fenebrutinib cs tscs btk variant molecular level investig reveal amino acid arginin contribut immens total bind energi establish crucial amino acid residu arg arg cs arg arg arg tscs bind fenebrutinib toward btk variant structur orient fenebrutinib within respect hydrophob pocket allow favor interact bind site residu account superior bind affin relat high hydrogen bond format toward tscs compar cs btk variant structur fenebrutinib impact stabil flexibl solvent access surfac area btk variant character various alter observ bound unbound structur prove enough disrupt biolog function find studi therefor provid insight inhibitori mechan fenebrutinib atomist level reveal high select toward btk variant insight could key design develop btk mutant inhibitor treat waldenstrm macroglobulinemia wm | D008258 | T191 |
36,222,927 | electron transfer extremophil bioelectrochem system interact bacteria archaea electrod relat new research field span fundament appli research influenc interdisciplinari research field microbiolog biochemistri biotechnolog well process engin although substanti understand electron transfer process microb anod microb cathod achiev mesophil organ mechan use microb extremophil condit still earli stage discoveri review current knowledg biochem solut evolv interact extremophil organ electrod end avail knowledg pure cultur extremophil microorgan compil studi extend help bioinformat analys potenti distribut differ electron transfer mechan extremophil microorgan | D000071825 | T001 |
36,222,916 | map base clone transcriptom analysi tiller small grain mutant rice g nucleotid substitut ostsg led tiller smaller grain rice particip phytohormon signal transduct starch sucros metabol rice one import food crop worldwid grain size tiller number import factor determin rice yield tiller small grain tsg mutant rice develop ethyl methanesulfon em mutagenesi smaller grain tiller higher yield per plant relat wild type wt base genet analysi tsg trait confer singl recess nuclear gene locat long arm chromosom fine map ostsg locus g nucleotid substitut identifi result mutat high conserv domain growth regul factor protein singl strand conform polymorph sscp marker develop base snp associ phenotyp segreg trait function complement ostsg tsg mutant wt led increas grain size weight differenti express gene deg identifi rna sequenc involv phytohormon signal transduct starch sucros metabol enzym link immunosorb assay elisa analysi detect variat indol acet acid iaa jasmon acid ja content tsg infloresc cellular organ degre chalki gel consist amylos content alkalin spread valu affect tsg grain find elucid regulatori mechan tsg trait mutant could use marker assist breed high yield good qualiti rice | D012275 | T168;T002 |
36,222,913 | vivo character key iridoid biosynthesi pathway gene catnip nepeta cataria use virus induc gene silenc demonstr enzym ges isi mlpl respons nepetalacton biosynthesi nepeta cataria nepetalacton main iridoid found nepeta genus well known psychoact effect hous cat moreov burgeon interest effect nepetalacton insect although enzym nepetalacton biosynthesi biochem assay vitro valid role enzym planta demonstr virus induc gene silenc vig silenc method reli transient transform approach particular success appli varieti non model plant use recent design visual marker depend vig system demonstr nepetalacton biosynthet enzym ges isi mlpl impact nepetalacton biosynthesi nepeta cataria | D027521 | T002 |
36,222,911 | microbi characterist metabolit profil high temperatur daqu differ matur stage matur period high temperatur daqu htd usual month characterist htd differ matur stage differ studi microbi characterist metabolit profil htd differ matur stage reveal combin physicochem detect third generat pacif bioscienc pacbio singl molecul real time smrt sequenc technolog gas chromatographi mass spectrometri gc ms gas chromatographi ion mobil spectrometri gc im result show htd matur month mixm higher saccharif power less cultur thermotoler bacteria fungi htd matur month mixm averag relat abund thermoactinomyc paenibacillus rasamsonia mixm higher mixm averag relat abund bacillus pseudomona thermoascus increas obvious prolong matur period streptomyc thermoactinomyc biomark mixm burkholderia pseudomona regard biomark mixm differ microbiota structur led differ enrich metabol pathway htd differ matur stage result differ flavor profil especi ethyl acet octen one e hexen trimethi ethylpyrazin pyrazin tetramethyl content microbiota metabolit characterist htd comprehens reflect htd qualiti differ matur stage provid refer determin optim matur time | D000434;D011719 | T109;T168 |
36,222,901 | synerg impact lignin lactobacillus plantarum dss induc coliti model via regul cd mir allianc chronic recurr immun system activ inflamm insid gastrointestin tract character inflammatori bowel diseas ibd due lack safeti efficaci tradit medic use food supplement ibd manag rise numer studi report certain food supplement varieti therapeut benefit ibd present studi mous model ibd use anti coliti effect lignin supplement lactobacillus plantarum l plantarum intestin inflamm anim model treat dextran sodium sulphat dss ill index increas colon length bodi weight declin effect revers lignin l plantarum treat group addit lignin l plantarum supplement inhibit dss induc increas level cytokin tnf pgml inf pgml il pgml tgf pgml gene protein express studi reveal lignin l plantarum supplement restor express e cad suppress express stat dss induc coliti model lignin l plantarum supplement also suppress cd express fold regul express mira fold dss induc coliti studi suggest lactobacillus lignin synergist treatment protect role inflammatori bowel diseas chang inflammatori cytokin mir express dss induc coliti | D003092;D018960;D015212;D048191;D035683 | T047;T116;T192;T007;T123;T114;T129 |
36,222,894 | chronic high rate pace induc heart failur preserv eject fraction like phenotyp ossabaw swine lack pre clinic larg anim model heart failur preserv eject fraction hfpef remain grow yet unmet obstacl improv understand complex condit examin whether chronic cardiometabol stress ossabaw swine possess genet propens obes cardiovascular complic produc hfpef like phenotyp swine fed standard chow lean n excess calori high fat high fructos diet obes n week lean n obes n swine subject right ventricular pace beatsmin week induc heart failur hf baselin blood pressur heart rate lv end diastol volum eject fraction similar group high rate pace increas lv end diastol pressur mmhg lean obes swine mmhg lean hf obes hf swine regress analys reveal upward shift lv diastol pressur vs diastol volum pace swine associ twofold increas myocardi fibrosi reduct myocardi capillari densiti hemodynam respons grade hemorrhag reveal decreas chronotrop respons reduct blood pressur lean hf obes hf swine without appreci chang myocardi oxygen deliveri transmur perfus find support high rate ventricular pace lean obes ossabaw swine initi under cardiac remodel accompani elev lv fill pressur normal eject fraction distinct pre clinic tool provid uniqu platform mechanist therapeut studi high complex syndrom | D006333 | T047;T046 |
36,222,892 | dlgap promot human colorect cancer progress tran activ myc substanti evid suggest non code rna play vital role human cancer especi long non code rna lncrna length greater nt herein found lncrna facilit human colorect cancer crc progress dlgap signific increas crc tissu cell line knockdown dlgap inhibit crc cell prolifer migrat invas vitro tumor growth vivo subcellular local dlgap transloc cytoplasm normal cell nucleus crc cell due reduc level n methyladenosin modif screen seri signal pathway found myc pathway involv effect dlgap silenc dlgap mark reduc myc mrna protein level blockad myc effect abolish enhanc aggress behavior crc cell caus dlgap overexpress mechanist dlgap direct bound ctcf well known transcript repressor myc result reduc bind ctcf myc promot activ myc transcript second hairpin structur dlgap critic interact dlgap ctcf nucleus taken togeth studi reveal oncogen regulatori axi dlgap asctcfmyc crc impli promis target therapi clinic applic | D062085;D035683;D015179 | T191;T123;T114 |
36,222,889 | site bond percol model epidem spread vaccin complex network studi diseas transmiss vaccin base network map sir model site bond percol model case vaccin probabl zero model degener bond percol model without immun use method generat function obtain exact theoret result epidem threshold averag outbreak size exact solut find epidem threshold increas averag outbreak size decreas vaccin probabl numer simul show size giant compon increas transmiss decreas probabl vaccin addit compar epidem threshold size giant compon poisson network exponenti network power law network use numer simul probabl vaccin fix epidem threshold smallest heterogen network size giant compon homogen network becom largest larg transmiss close | D058872 | T067 |
36,222,884 | tempor spatial goal direct reach upper limb prosthesi user understand fundament characterist prosthet movement control imper improv prosthesi design train studi quantifi use upper limb prosthesi affect perform goal direct reach task nine prosthesi user unilater transradi limb absenc nine healthi control complet seri goal direct reach movement differ goal one spatial three tempor differ goal frequenc quantifi end point accuraci smooth peak speed spatial task tempor accuraci horizont distanc speed tempor task tempor task also use goal equival manifold gem approach decompos variabl movement distanc speed perpendicular tangenti gem detrend fluctuat analysi dfa quantifi tempor persist time seri spatial task movement made prosthes less smooth larger end point error slower peak speed compar control limb p mean variabl distanc speed perpendicular deviat decreas increas goal frequenc p result suggest prosthesi user suffici intern model success complet ballist movement unabl accur complet movement requir substanti feedback | D001186 | T074 |
36,222,879 | distribut interact effect heavi metal soil maiz zea may l system mercuri mine area southwestern china concentr interact effect benefici element ie se mo zn heavi metal cd hg pb maiz zea may l grown lime soil andor soil mercuri tail investig studi result show concentr heavi metal ie hg pb soil tail higher lime soil concentr benefici element ie mo zn maiz grown soil tail higher maiz grown lime soil mean concentr se mo zn maiz grown soil tail mgkg mgkg mgkg ph antagonist effect play import role concentr mo zn maiz se concentr maiz control plant media | D008628;D012989;D019216 | T131;T196 |
36,222,875 | comput tomographi magnet reson imag cardiac diagnost choos right modal guid base new guidelin european societi cardiolog esc guidelin updat european societi cardiolog esc noninvas radiolog cross section imag take increas promin role time invas diagnost approach becom less import especi diagnosi treatment chronic acut coronari syndrom fundament chang clinic routin addit cross section imag also offer altern diagnost algorithm cardiac patholog especi echocardiographi increas use differenti diagnosi cardiac diseas radiologist awar recommend current guidelin encourag establish clinic practic paper summar indic cross section cardiac imag focus new recommend esc guidelin address specif strength weak modal | D003324;D006321;D008279;D014057 | T047;T023;T059;T060;T170 |
36,222,863 | hypox precondit reduc endotheli ischemia reperfus injuri older adult sudden blood flow restor ischem vessel paradox damag endotheli cell ischem precondit caus repeat bout brief ischemia use local remot cuff inflat reperfus attenu endotheli dysfunct follow ischemia reperfus injuri young adult consist protect endotheli function older adult prone ischem event intermitt exposur system hypoxemia induc via brief bout breath low level oxygen attenu endotheli dysfunct follow ischemia reperfus injuri young adult aim studi determin whether system hypox precondit protect ischemia reperfus injuri older adult twelv adult five women yr particip random crossov trial endothelium depend vasodil assess brachial arteri flow mediat dilat use semiautom diagnost ultrasound system min blood flow occlus preced either intermitt hypoxia consist three min hypox cycl oxygen satur interspers min room air cycl intermitt normoxia consist three min normox cycl separ min room air cycl preced intermitt normoxia ischemia reperfus injuri reduc flow mediat dilat contrast flow mediat dilat reduc ischemia reperfus injuri preced intermitt hypoxia conclus hypox precondit signific attenu reduct brachial arteri flow mediat dilat induc ischemia reperfus injuri older adult greater risk ischem event | D019194;D015427 | T061;T037 |
36,222,861 | constitut assembl ca entri unit soleus muscl calsequestrin knockout mice calcium ca entri unit ceus junction within band sarcomer stack sarcoplasm reticulum sr cisterna extens transvers tubul ceus contain stim orai protein molecular machineri store oper ca entri soce extensor digitorum longus edl fiber wild type wt mice ceus transient assembl acut exercis disassembl sever hour thereaft contrast calsequestrin casq ablat induc compensatori constitut assembl ceus edl fiber result enhanc constitut maximum soce counteract sr ca deplet repetit activ howev whether ceus form slow twitch fiber express skelet casq cardiac casq isoform unknown herein compar structur function soleus muscl wt knockout mice lack either casq casq null casq dcasq null ultrastructur analys show srt tubul junction band virtual ident ceus edl muscl present frequent casq null wt mice dcasq null exhibit highest incid greater incid ceus soleus dcasq null mice correl increas specif forc product repetit high frequenc stimul depend ca entri consist orai express signific increas soleus casq null mice even dcasq null mice compar wt togeth result strengthen concept ceu assembl strong depend casq express provid altern sourc ca need refil sr ca store maintain specif forc product sustain muscl activ | D002118;D002155 | T121;T123;T116;T196 |
36,222,860 | fibroblast growth factor homolog factor attenu excit drg neuron fibroblast growth factor homolog factor fhfs cytosol member superfamili fgf protein four member subfamili fhf differenti express multipl tissu isoform depend manner mutat fhf protein associ multipl neurolog disord fhf protein bind cooh terminus voltag gate sodium nav channel regul current amplitud gate properti channel fhf express dorsal root ganglia drg neuron two main splice isoform fhfa fhfb differ length sequenc nh termini shown differenti regul gate properti nav channel major driver drg neuron fire fhf express level downregul peripher nerv axotomi suggest may regul neuron excit via action nav channel injuri previous shown knockdown fhf lead gain function chang nav gate properti enhanc reprim increas current densiti hyperpolar activ posit knockdown fhf might also lead drg hyperexcit show knockdown either fhfa alon isoform fhf result increas drg neuron excit addit demonstr supplement fhfa fhfb reduc drg neuron excit overexpress fhfa fhfb also reduc excit drg neuron treat cocktail inflammatori mediat model inflammatori pain data suggest increas neuron excit nerv injuri might trigger part via loss fhf nav interact new noteworthi fhf known bind modul function nav fhf express also reduc nerv injuri demonstr knockdown fhf express increas drg neuron excit import overexpress fhf reduc drg excit basal condit presenc inflammatori mediat model inflammatori pain result suggest fhf could potenti use tool reduc drg neuron excit treat pain | D005727;D010523 | T023;T047 |
36,222,849 | synthesi ortho phosphat hetero arylamin cascad atherton todd reaction rearrang arylhydroxylamin dialkyl phosphit practic facil strategi synthesi ortho phosphat hetero arylamin readili avail arylhydroxylamin dialkyl phosphit via cascad atherton todd reaction rearrang develop method amen various arylhydroxylamin phenylhydroxylamin naphthylhydroxylamin pyridylhydroxylamin mild reaction condit oxid free good function group compat excel regioselect | D017905 | T197 |
36,222,842 | patient chest tight left arm neck tingl case report describ diagnosi aortic dissect patient present chest tight light headed tingl sensat left arm neck | D001132;D002637 | T047;T184;T029 |
36,222,836 | non catalyt allosteri tat phospho switch drive dynam microtubul acetyl spatiotempor dynam microtubul acetyl under divers physiolog patholog event despit ubiqu molecular mechan regul sole microtubul acetyl agent tubulin n acetyltransferas tat remain obscur report dynam intracellular local tat along catalyt activ determin effici microtubul acetyl specif newli identifi conserv signal motif intrins disord c terminus tat consist three compet regulatori element nuclear export nuclear import cytosol retent balanc tune via phosphoryl cdk pka ck dephosphoryl ppa unphosphoryl form bind importin resid cytosol nucleus phosphoryl form bind specif adapt accumul cytosol maxim substrat access unlik molecul similar phospho regul signal motif tat uniqu use nucleus hideout alloster spatial regul tat function may help uncov spatiotempor code microtubul acetyl normal aberr cell behavior | D000123;D008870;D014404 | T026;T126;T116;T123 |
36,222,833 | dna base optic quantif ion transport across giant vesicl accur measur ion permeabl cellular membran remain challeng due lack suitabl ion select probe use giant unilamellar vesicl guv membran model direct visual mass transloc singl vesicl level ion transport indic fluoresc adjust dna base sensor accur detect sub millimolar variat k concentr combin microfluid employ dna base k sensor extract permeat coeffici potassium ion measur k permeabl coeffici least order magnitud larger previous report valu bulk experi show permeat rate across lipid bilay increas presenc octanol addit analysi k flux differ concentr gradient allow us estim complementari h flux dissip charg imbal across guv membran subsequ show sensor quantifi k transport across prototyp cation select ion channel gramicidin ompf reveal relat h k select result show gramicidin much select proton ompf h k permeabl ratio | D006096;D053835 | T109;T116;T195 |
36,222,828 | nuclear tension control mitot entri regul cyclin b nuclear transloc cell prepar divid must ensur enough space avail assembl mitot machineri without perturb tissu homeostasi cell undergo seri biochem reaction regul cyclin b cdk trigger cytoskelet reorgan ensur coordin cytoplasm nuclear event along biochem event control mitot entri mechan forc recent emerg import player cell cycl regul howev exact link mechan forc biochem pathway control mitot progress remain unknown identifi tension depend signal nucleus set time nuclear envelop permeabil nep mitot entri signal reli actomyosin contractil unfold nucleus g transit activ stretch sensit cpla nuclear envelop regul nuclear transloc cyclin b data demonstr nuclear tension g transit contribut time effici mitot spindl assembl prevent chromosom instabl | D021581;D056744;D008938 | T043;T123;T116 |
36,222,821 | role bacteriophag therapi resist infect transplant recipi multidrug resist organ mdros preval transplant recipi associ poor outcom review recent case phage therapi use treat recalcitr infect transplant recipi explor futur role therapi set | D000071059;D001424 | T061;T047 |
36,222,799 | enhanc sampl aid design molecular photoswitch advanc evolv field atomist simul promis import insight design fundament understand novel molecular photoswitch use state art enhanc simul techniqu unravel complex multistep chemistri donor acceptor stenhous adduct dasa reaction discoveri workflow consist enhanc sampl effici chemic space explor refin newli observ pathway accur ab initio electron structur calcul structur modif introduc design principl within futur generat dasa showcas discoveri workflow recov full photoswitch mechan dasa also predict plethora new plausibl thermal pathway suggest way experiment valid furthermor illustr tunabl newli discov reaction lead potenti avenu control dasa dynam multipl extern stimuli overal insight could offer altern rout increas effici control dasa photoswitch mechan provid new element design complex light respons materi | D003198 | T066 |
36,222,797 | develop natur prenylflavon artocarpin artocarpus hirsutus potenti lead target pathogen multidrug resist staphylococcus aureus persist biofilm detect resist genus artocarpus nutraceut wide use tradit medicin treatment mani chronic diseas includ infect artocarpus hirsutus lam evergreen tree endogen western ghat india well document medicin plant hortus malabaricus oldest comprehens print book natur plant wealth asia herein describ artocarpin major isoprenyl flavonoid isol stem bark hirsutus lam explan behind indigen knowledg report treatment various skin ailment artocarpin noncytotox isoprenyl flavonoid rapid bactericid multipl world health organ prioriti pathogen includ multidrug resist staphylococcus aureus enterococcus sp extend postantibiot effect artocarpin ah synerg gentamicin linezolid inhibit bacteria differ physiolog state includ biofilm macrophag induc resist aureus despit repeat exposur artocarpin induc rapid cellular lysi confirm fluoresc microscopi scan electron microscopi analysi well measur signific increas extracellular concomit decreas intracellular adenosin triphosph level test vivo ah almost effect vancomycin reduc bacteri load murin thigh skin infect model compar standard care soc antibiot high signific sinc ah direct natur entiti evalu without pharmaceut modif express robust vitro vivo antibacteri activ compar high optim soc compar could consid effect clinic antibacteri drug lead | D031622;D055624;D013203 | T007;T047;T168;T002 |
36,222,775 | palliat care movement disord articl review role palliat care treatment patient life limit neurodegen movement disord | D032722;D009069 | T047;T058 |
36,222,774 | diagnos common movement disord children articl design help clinician identifi common pediatr movement disord recogn benign versus patholog movement infanc childhood particular focus treatabl condit miss | D009069;D017216 | T047;T058 |
36,222,773 | dystonia articl discuss recent find regard diagnosi classif manag genet idiopath dystonia | D001905;D004421;D020821;D009069 | T047;T116;T131;T121;T048;T184 |
36,222,772 | neurodegen cerebellar ataxia neurodegen cerebellar ataxia divers collect diseas unifi gait balanc abnorm appendicular incoordin abnorm eye movement speech differenti diagnosi broad rang paraneoplast syndrom progress quit rapid unidentifi genet disord progress slowli cours decad articl highlight diagnost process includ differenti diagnosi well treatment approach symptomat manag pillar treatment physic occup speech therapi well counsel discuss diseas prognosi genet reproduct choic mani way help patient neurodegen cerebellar ataxia improv qualiti life | D002524 | T047;T184;T033 |
36,222,771 | chorea articl provid overview diagnost therapeut approach patient chorea phenomenolog chorea describ addit common hyperkinet movement may mistaken coexist chorea chorea acquir hereditari key histor clinic featur aid determin etiolog review pharmacolog nonpharmacolog treatment strategi discuss | D002819;D006816 | T047 |
36,222,770 | progress supranuclear palsi corticobas syndrom differenti diagnosi parkinson tremor rigid bradykinesia gait difficultypostur instabl broad includ two neurodegen condit exist clinicopatholog spectrum progress supranuclear palsi psp corticobas syndrom cbs earli clinic cours psp cbs may difficult distinguish parkinson diseas sever ill crucial implic manag prognosi | D000088282;D010300;D020734;D013494 | T050;T047 |
36,222,769 | multipl system atrophi patient multipl system atrophi msa present divers clinic manifest clinic care requir complex requir thought approach emerg symptom treatment decis | D001342;D019578 | T047;T046 |
36,222,768 | diagnosi treatment essenti tremor essenti tremor chronic progress syndrom primarili present action tremor involv arm hand articl review histori physic examin featur pertin diagnosi differenti diagnos treatment approach optim control symptom | D004421;D020329;D010300 | T047;T184 |
36,222,767 | diagnosi treatment cognit neuropsychiatr symptom parkinson diseas dementia lewi bodi articl summar under biolog current diagnost treatment strategi cognit neuropsychiatr featur parkinson diseas pd dementia lewi bodi dlb | D060825;D020961;D010300 | T047;T048 |
36,222,766 | surgic therapi parkinson diseas parkinson diseas pd progress neurodegen disord often difficult manag medic alon articl review current therapeut surgic intervent pd patient select criteria time patient referr surgic servic procedur overview futur direct | D046690;D010300 | T061;T047 |
36,222,765 | diagnosi medic manag parkinson diseas parkinson diseas pd common neurodegen movement disord preval rise world popul age may present motor nonmotor symptom symptomat treatment signific improv qualiti life articl provid overview workup differenti diagnosi pd review genet environment risk factor current treatment | D010300 | T047 |
36,222,764 | prodrom synucleinopathi articl describ prodrom synucleinopathi | D020961;D019578;D010300;D000080874 | T047;T046 |
36,222,760 | heat confin aerogel enabl supramagnetotherm effect trigger nitric oxid generat reduc heat dissip play indispens role boost magnetotherm effect receiv scant attent herein magnetotherm aerogel combin effici magnetotherm convertor heat generat high porous aerogel reduc heat dissip develop heat confin show larg thermal resist high infrar absorpt effect confin heat regul interior thermal conduct radiat exhibit supramagnetotherm effect addit waterproof beeswax coat achiev neglig heat loss supramagnetotherm effect even high thermal diffus aqueous media proof concept synthes heat trigger nitric oxid precursor integr rapid generat mmin result antibacteri effect verifi supramagnetotherm effect work provid effici strategi promot magnetotherm effect offer inspir build heat trigger system | D006358;D009569 | T121;T197;T070 |
36,222,749 | intern standard assist surfac enhanc raman scatter nanoprob ntp recognit unit ratiometr imag hydrogen sulfid live cell hydrogen sulfid h third endogen gasotransmitt close associ various physiolog patholog process wherea mani aspect function remain unclear effect tool accur detect h live organ urgent need herein report intern standard assist surfac enhanc raman scatter ser nanoprob ratiometr detect h vitro live cell base reduct nitro h nanoprob consist intern standard mercaptobenzonitril mpbn embed core molecul shell au nanoflow au mpbn au high plasmon activ ser substrat nitrothiophenol ntp molecul immobil surfac h recognit unit addit h nitro peak cm decreas meanwhil three obvious new peak appear cm relat vibrat dimer product dimercaptoazobisbenzen dmab aminothiophenol atp howev peak intens cm deriv mpbn influenc outer environ thus h level abl determin base ratio two peak intens detect limit low notabl prove ser nanoprob au mpbn au ntp could ratiometr imag endogen exogen h live cell anticip au mpbn au ntp could appli studi h relat physiolog function futur | D006862;D064426;D053768 | T073;T131;T123;T130;T197 |
36,222,746 | concis chemoenzymat synthesi gedunin limonoid attract signific attent synthet communiti owe strike structur complex medicin potenti recent effort notwithstand synthet access mani intact ring seco limonoid still remain elus report first de novo synthesi gedunin ring seco limonoid hsp inhibitori activ proceed step two enabl featur strategi applic modern catalyt transform set key quaternari center carbocycl core use biocatalyt oxid c establish chemic handl access ring enon motif strategi present herein may provid entri point wider rang oxid limonoid | D036701 | T109 |
36,222,744 | schiff base complex coval anchor luminophor self enhanc electrochemiluminesc detect neomycin novel electrochemiluminesc ecl amplif strategi establish aim overcom inher shortcom current oxygen coreact ecl system macrocycl schiff base fe complex ration design novel integr ecl emitt iminium linkag n aminobutyl n ethylisoluminol abei phenanthrolin dicarbaldehyd pdl postmetal macrocycl schiff base coval combin luminophor abei catalyt center endow novel ecl emitt remark redox electrocatalyt properti signific enhanc ecl effici high content ferrous iron domin activ low spin fe state great contribut inher catalyt activ activ ration modif luminophor optim spatial distribut simultan shorten speci transport distanc coreact radic generat situ dissolv result signific self enhanc ecl effici neomycin pose grow threat aquat biodivers environment safeti model antibiot success detect detect limit pm n clarifi promis applic prospect new luminophor embed ecl amplif strategi biolog analysi environment monitor | D015374;D053768 | T059;T075;T073 |
36,222,719 | improv stabil enhanc vivo efficaci pcsk inhibitori peptid optim peptid stabil essenti develop peptid bona fide altern approv monoclon antibodi clear case mani peptid report antagon proprotein convertas subtilisin likekexin type pcsk clinic valid target lower cholesterol howev effect optim stabil vivo activ particular effect bind albumin emerg drug design paradigm studi peptid lead studi optim pcsk inhibitori peptid mutagenesi conjug short lipid tag design p alb fusion peptid strong affin human serum albumin although attach tag reduc activ pcsk evid surfac plasmon reson bind enzym link immunosorb competit assay cellular assay activ activ remain nanomolar rang nm p alb peptid except stabl human serum half live exceed h correl longer half live mice min compar unconjug peptid furthermor decreas vitro bind deleteri vivo function show engend albumin bind improv low densiti lipoprotein receptor recoveri cholesterol lower activ inde peptid p albn achiev similar function endpoint approv anti pcsk antibodi evolocumab albeit higher dose studi illustr optim stabil instead bind affin effect way improv vivo function | D007164;D000911 | T116;T130;T129 |
36,222,708 | synthesi vitro profil vivo evalu benzohomoadamantan base urea viscer pain new indic solubl epoxid hydrolas inhibitor solubl epoxid hydrolas seh suggest pharmacolog target treatment sever diseas includ pain relat disord herein report medicin chemistri around new benzohomoadamantan base seh inhibitor sehi order improv drug metabol pharmacokinet properti previous hit extens vitro screen cascad molecular model vivo pharmacokinet studi two candid evalu vivo murin model capsaicin induc allodynia two compound show anti allodyn effect dose depend manner moreov potent compound present robust analges efficaci cyclophosphamid induc murin model cystiti well establish model viscer pain overal result suggest pain bladder syndrom new possibl indic sehi open new rang applic viscer pain field | D004851;D059265 | T184;T126;T116 |
36,222,701 | three compon asymmetr ni catalyz dicarbofunction unactiv alken via stereoselect migratori insert asymmetr dicarbofunction unactiv alken aryl iodid arylalkenylboron ester nickelbioxazolin catalysi disclos wide array aryl alkenyl nucleophil toler furnish product good yield high enantioselect addit termin alken disubstitut intern alken particip reaction establish two contigu stereocent high diastereoselect moder enantioselect combin experiment comput techniqu shed light mechan catalyt transform point close shell pathway enantiodetermin migratori insert step stereoinduct aris synergist interact steric bulki achir sulfonamid direct group hemilabil bident ligand | D000475;D009532 | T109;T123;T196 |
36,222,673 | model base analysi health impact covid disrupt primari cervic screen time sinc last screen current futur disrupt evalu temporari disrupt primari cervic cancer cc screen servic may differenti impact women due heterogen screen histori test modal use three cc model project short long term health impact assum under primari screen frequenc ie year three altern covid relat screen disrupt scenario ie year delay versus delay context cytolog base human papillomavirus hpv base screen model project relat increas symptomat detect cancer case year delay period higher polici cervix higher harvard higher miscan cervix underscreen women whose last cytolog screen year prior disrupt period compar guidelin compliant women ie last screen year prior disrupt woman lifetim temporari covid relat delay less impact lifetim risk develop cc screen frequenc test modal howev cc risk increas disproportion longer time elaps sinc woman last screen time disrupt excess risk given delay period general lower hpv base screener cytolog base screener independ model predict main driver cc risk screen frequenc screen modal overal impact disrupt pandem cc outcom may small howev screen disrupt disproportion affect underscreen women underpin import reach women critic area focus regardless temporari disrupt | D000086382;D030361;D002583 | T191;T047;T067 |
36,222,668 | cinderella effect lethal child abus genuin larg comment nobe et al nobe et al combin novel analys homicid victim british preschool children critiqu previous research report larg cinderella effect excess risk stepchildren domain wherea nobe colleagu empir contribut use critiqu contain factual error misrepresent literatur support conclus magnitud effect great exagger show address nobe et al mani misstat review relev literatur ignor fatal babi batter particular found exhibit cinderella effect order fold mani studi sever countri includ britain nobe et al effort deni realiti misguid psycinfo databas record c apa right reserv | D002649 | T048 |
36,222,667 | rank base altern mean base ensembl model satisfact earn comment putnam farr morewedg much satisfact deriv new salari receiv bonus payment experi peopl judg monetari amount isol compar amount judgment context sensit key question howev context affect judgment across eight experi putnam farr morewedg show peopl self report satisfact sum money predict differ amount highest lowest amount receiv other author found evid peopl judgment sensit rank posit monetari amount among reward putnam farr morewedg explain result refer ensembl represent literatur show peopl accur estim summari statist maximum mean stimulus distribut commentari argu propos interpret inconsist extens theoret empir research show judgment stimuli reflect relat rank posit stimuli within comparison context build research show experiment result report putnam farr morewedg explain assumpt peopl use contextu inform infer distribut monetari amount judg individu amount relat rank posit within infer distribut infer distribut theori account empir result report origin studi remain consist general well establish principl rank base judgment psycinfo databas record c apa right reserv | D007600;D010549 | T041;T033 |
36,222,666 | centrosom protein cep regul human pluripot stem cell differenti toward kidney lineag embryon develop mesoderm undergo pattern divers lineag includ axial paraxi later plate mesoderm lpm within lpm call intermedi mesoderm im form kidney urogenit tract progenitor cell remain lpm form cardiovascular hematopoiet mesotheli addit progenitor cell signal regul earli lineag decis incomplet understood found centrosom protein cep centriolar compon necessari primari cilia format mutat pediatr kidney diseas influenc differenti human induc pluripot stem cell hipsc toward im induc inactiv delet cep hipsc appli day vitro protocol im kidney progenitor differenti base time applic wnt fgf agonist character induc mesoderm cell popul use singl cell bulk transcriptom test abil form kidney structur subsequ organoid cultur hipsc homozyg cep inactiv normal regard morpholog transcriptom induc differenti im progenitor cell perturb mesoderm cell induc day monolay cultur cep defici hipc exhibit absent elong primari cilia display decreas express critic im gene pax eya hoxb aberr induct lpm marker eg foxf foxf fendrr hand hand upon subsequ organoid cultur wildtyp cell differenti form kidney tubul glomerular like structur wherea cep defici cell fail generat kidney cell type instead upregul cardiomyocyt vascular general lpm progenitor marker data suggest cep regul balanc im lpm format human pluripot stem cell identifi potenti link centriolar ciliari function mesoderm lineag induct | D039904;D057026 | T025 |
36,222,651 | na k pump domin control glycolysi hippocamp dentat granul cell cellular atp consum perform energet expens task must replenish new atp activ metabol neuron stimul energet demand process transient activ aerob glycolysi precis mechan under glycolysi activ determin previous show neuron glycolysi correl ca influx activ feedforward ca signal daz garca et al sinc atp power na ca pump activ increas follow stimul restor ion gradient estim consum neuron atp aim determin coupl neuron glycolysi activ use two photon imag fluoresc biosensor dye dentat granul cell soma acut mous hippocamp slice observ product cytoplasm nadh byproduct glycolysi strong coupl chang intracellular na intracellular ca could increas nadh product forward na ca exchang na k pump activ intact addit antidrom stimul induc intracellular na increas reduc block ca entri result indic neuron glycolysi activ predomin respons increas activ na k pump strong potenti na influx na ca exchang extrus ca follow stimul | D009243;D002118 | T121;T196;T123;T114 |
36,222,650 | high resolut speci assign anophel mosquito use k mer distanc target sequenc anospp amplicon panel genus wide target sequenc panel facilit larg scale monitor anophel speci divers combin inform nuclear amplicon present anospp panel allow senstiv specif speci assign singl gene eg coi barcod desir light permeabl speci boundari present nnova method use nearest neighbour nn variat autoencod vae appli k mer result anospp amplicon sequenc order hierarch assign speci ident nn step assign sampl speci group compar k mer aris haplotyp amplicon sequenc refer databas vae step requir distinguish close relat speci also suffici resolut reveal popul structur within speci test independ sampl amplicon coverag nnova correct classifi speci level sampl within gambia complex sampl outsid complex appli nnova two thousand new sampl burkina faso gabon identifi unexpect speci gabon nnova present approach may valu target sequenc panel method use survey anophel speci divers plasmodium transmiss pattern space time larg scale plan analys half million mosquito next five year | D000852 | T204 |
36,222,649 | domin general versus specif aspect wellb student subject wellb questionnair student subject wellb questionnair sswq item measur school specif subject wellb intend mental health screen applic extend past valid work scrutin sswq previous propos factor structur ie four group factor one general factor score reliabl use two random subset data sampl adolesc grade result exploratori confirmatori factor analys suggest four item relat educ purpos ep group factor coher expect unlik item three group factor revis item model exclud ep item defens across subsampl model base reliabl indic item general factor score consist strong show except high correl origin item version r yet uniqu reliabl group factor score compar weaker recommend futur research reevalu sswq item content factor structur consid use model base factor score least addit sum score analys oper latent factor framework emphas reli general rather group factor score pars individu differ student subject wellb make critic decis regard intervent resourc alloc psycinfo databas record c apa right reserv | D013334 | T098;T081 |
36,222,647 | photoenhanc cn stretch vibrat intens aromat nitril cn stretch vibrat versatil infrar ir report use wide rang applic aim expand spectroscop util herein show use cyanoindol cyano azaindol exampl photoexcit signific shift frequenc cn enhanc molar extinct coeffici cn vibrat mode aromat nitril indol deriv enhanc factor reach moreov find solvent relax excit electron state alway lead increas cn effect cn depend solut solvent taken togeth result demonstr solvent relax differ affect local environ nitril group conjug indol ring import cn stretch vibrat serv sensit ir probe charg electron transfer process aromat nitril involv | D014732;D009570 | T121;T109;T070 |
36,222,640 | pupillometri track error interv time recent primat studi suggest potenti link pupil size subject elaps durat sought investig relationship pupil size perceiv durat human particip perform two tempor bisect task subsecond suprasecond interv rang subsecond task pupil diamet greater stimulus process shorter interv overestim also stimulus offset longer interv underestim contrast suprasecond task larger pupil diamet observ late stimulus offset phase prior respons prompt longer interv underestim pattern result suggest pupil diamet relat error monitor mechan interv time result odd direct relationship pupil size percept durat suggest pupillometr variat might play key role signifi error relat tempor judgment psycinfo databas record c apa right reserv | D007600 | T041 |
36,222,639 | limit cerebellar contribut suprasecond time across differ task demand involv cerebellum suprasecond interv time ie time second minut rang controversi limit amount evid human nonhuman primat rodent shown later cerebellum includ later cerebellar nucleus lcn may necessari success suprasecond time perform howev mani exist studi pitfal limit time outcom measur confound task demand addit mani exist studi reli well train subject approach may drawback cerebellum hypothes carri ongo error correct limit time variabl use experienc subject past time studi may miss critic window cerebellar involv experi describ pharmacolog inactiv rat lcn across three differ peak interv time task structur task address past confound collect time variabl measur character perform target durat acquisit across various task find strong support cerebellar involv suprasecond interv time find support exist distinct cerebellum subsecond interv time brain region psycinfo databas record c apa right reserv | D013998 | T041 |
36,222,638 | still stuck stopwatch time integr part adapt behavior continu adapt dynam structur ever chang environ recent theoret approach move idea time aris special stopwatch like mechan instead propos view time inher encod host neural dynam howev argu much theoriz even intrins view propos still driven implicit assumpt clear mark isol stopwatch like interv fundament unit time environ assumpt ignor challeng interact uncertain ever chang environ relev interv need distil continu stream action event b time never estim sake instead use adapt tune cognit discuss intrins adapt view contrast studi isol stopwatch interv consid organ learn adapt behavior tempor structur experi natur world psycinfo databas record c apa right reserv | D003071;D007858 | T061;T041;T062 |
36,222,637 | dopamin mediat bidirect updat interv time role dopamin da reward predict error rpe signal reinforc learn rl task well establish past decad recent work shown rpe interpret also account effect da interv time control speed subject time accord theori time dopamin signal relat reward deliveri dictat whether subject time speed slow earli da signal speed subject time late signal slow test bidirect predict reanalyz measur dopaminerg neuron substantia nigra par compacta mice perform self time movement task use slope ramp dopamin activ readout subject time speed found trial trial chang slope could predict time dopamin activ previous trial result provid key piec evid support unifi comput theori rl interv time psycinfo databas record c apa right reserv | D004298;D012054 | T061;T121;T109;T123;T041 |
36,222,636 | time neural timescal tempor cognit special issu provid repres snapshot cut edg behavior neurosci research sens time cognit behavior function neural process psycinfo databas record c apa right reserv | D003071;D009488 | T091;T041 |
36,222,628 | insight trajectori impact psychosoci function year follow studi first episod psychosi patient insight consid core symptom psychosi close relat function outcom howev littl known regard role insight progress differ long term function subdomain among first episod psychosi fep patient total particip follow year period latent class mix model use identifi trajectori class three differ insight dimens multivari analys perform explor predict valu insight dimens long term trajectori psychosoci function year follow period includ analys complet set baselin follow measur three differ trajectori improv continu awar worsen differenti insight dimens result continu awar common trajectori awar mental ill baselin repres one main predictor long term instrument global function moreov enhancementmainten ill awar signific relat better interperson function earli intervent program promot acquisit awar earli stage psychot disord could relev impact long term function fep patient insight dimens show most trait like properti although consider proport fep patient experienc chang insight dimens follow period psycinfo databas record c apa right reserv | D000083623;D011618 | T048;T033 |
36,222,627 | assess general versus specif liabil extern problem adolesc concurr prospect predict symptom conduct disord adhd substanc use studi explor general versus specif two trait liabil factor extern problem disinhibit callous concurr prospect predict symptom conduct disord attent deficithyperact disord adhd substanc use ie alcohol use disord histori illicit substanc use disinhibit involv impuls unrestrain cognit behavior style callous entail disposit lack social emot sensit particip european adolesc multisit imagen project complet questionnair clinic interview age n mage femal n mage femal disinhibit relat concurr prospect greater symptom conduct disord adhd alcohol use disord higher score general extern factor greater likelihood tri illicit substanc callous select relat greater conduct disord symptom find indic disinhibit confer broad liabil extern spectrum disord perhap due affili deficit execut function contrast callous appear repres specif liabil antagonist aggressiveexploit form extern exemplifi antisoci behavior result support util development ontogenet hierarch dimension model psychopatholog import implic earli assess risk extern problem psycinfo databas record c apa right reserv | D000437;D001289;D019955;D019966 | T048;T033 |
36,222,626 | general psychopatholog factor earli middl childhood longitudin genet risk analys accumul research suggest structur psychopatholog best repres continu higher order dimens includ general dimens p specif dimens exampl extern intern factor aim replic p earli childhood b examin stabil chang genet environment influenc psychopatholog factor earli midchildhood c extern valid factor key construct psycholog function test whether factor predict earli life measur eg neonat complic data base longitudin isra studi twin mother report pregnanc neonat condit repeat fill questionnair twin extern intern symptom age cognit abil assess lab age person trait self esteem life satisfact self report twin age bifactor model includ p extern intern factor fit data best associ p cognit abil person replic longitudin twin analys indic p high herit substanti proport genet influenc stabl age specif intern extern factor net p also high herit higher p predict lower self esteem age earli life measur strong associ psychopatholog result show p discern earli childhood high herit prospect associ negat outcom psycinfo databas record c apa right reserv | D001523 | T048 |
36,222,625 | three recommend base comparison reliabl valid predomin model use research empir structur psychopatholog correct forb et al report error three recommend base comparison reliabl valid predomin model use research empir structur psychopatholog miriam k forb ashley l green holli f levin aspenson ashley l watt michael hallquist benjamin b lahey kristian e markon christoph j patrick jennif l tackett irwin waldman aidan g c wright avshalom caspi masha ivanova roman kotov dougla b samuel nichola r eaton robert f krueger journal abnorm psycholog apr vol articl figur error latent variabl label model wherebi fear distress invert onlin version articl correct follow abstract origin articl appear record present studi compar primari model use research structur psychopatholog ie correl factor higher order bifactor model term structur valid model fit factor reliabl longitudin measur invari concurr prospect predict valid relat import outcom longitudin consist individu factor score profil two simpler operation general factor psychopatholog also examin singl factor model count diagnos model estim base structur clinic interview diagnos two longitudin wave nation repres data unit state n n model includ narrow factor fear distress extern need captur observ multidimension data correl factor higher order model narrow factor reliabl larg invari time consist associ indic adapt function moder stabil within individu time contrast fear distress specif factor bifactor model show good reliabl valid throughout analys notabl general factor psychopatholog p factor perform similar well across test reliabl valid regardless whether higher order bifactor model use simplest singl factor model also compar across test except model fit given limit categor diagnos import repeat analys use dimension measur conclud aim understand structur correl psychopatholog import look beyond model fit indic choos differ model b examin reliabl latent variabl direct c cautious isol interpret uniqu effect specif psychopatholog factor regardless model use psycinfo databas record c apa right reserv | D001523;D011599 | T091;T048 |
36,222,607 | sar cov rna viabil high touch surfac evalu continu flow ozon treatment covid emerg highlight import prevent system environ mental microbiolog monitor fundament element respons epidem threat individu collect health use autom touch room disinfect system elimin reduc depend oper thus allow improv effect termin disinfect | D000086382;D010126 | T103;T047;T067 |
36,222,606 | synergi univers educ primari health care meet popul health need last decad world health organ sensit countri adopt primari health care approach health system also import invest educ primari health care inde need spread comprehens cultur health start univers educ continu whole work life cycl due current medic model approach patient specif patholog disciplin ineffici generat due lack communic integr manag chronic public health build dynam model mechan pursu health need express popul educ play crucial role enhanc countri resili protect health inhabit health worker consid aspect health beyond specif phase diagnosi treatment continu educ train key element focus satisfi popul health need | D011634;D003142 | T054;T091;T170;T097;T080 |
36,222,600 | ti c x mxene matrigel electroacoust stimul promot growth spiral ganglion neuron cochlear implant becom effect treatment method patient profound total hear loss howev therapeut efficaci depend number normal physiolog function cochlear implant target spiral ganglion neuron sgns electr stimul use effect cue regul morpholog function excitatori cell therefor import develop effici cochlear implant electroacoust stimul ea system studi behavior sgns work present electr stimul system construct combin cochlear implant conduct ti c x mxene matrigel hydrogel sgns cultur ti c x mxene matrigel hydrogel expos electr stimul transduc cochlear implant demonstr low frequenc stimul promot growth cone develop neurit outgrowth sgns well signal transmiss cell work may potenti valu clinic applic ti c x mxene hydrogel optim postop listen effect cochlear implant benefit peopl sensorineur hear loss | D013136;D014025 | T023;T196 |
36,222,596 | multifunct composit hydrogel bacteri captur growthelimin sens applic hydrogel cross link network hydrophil polym chain three dimension structur owe uniqu featur applic hydrogel bacterialantibacteri studi bacteri infect manag grown import recent year trend like continu due rise bacteri infect antimicrobi resist exploit physicochem characterist inher natur hydrogel develop achiev bacteri captur detect bacteri growth elimin antibiot deliveri bacteri sens tradit develop hydrogel bacterialantibacteri studi focus achiev singl function antibiot deliveri antibacteri activ bacteri growth bacteri detect howev recent studi demonstr fabric multifunct hydrogel singl hydrogel capabl perform one bacterialantibacteri function composit hydrogel consist number singl function hydrogel exhibit bacterialantibacteri function synergist review first highlight hydrogel featur critic bacteri studi infect manag specif address uniqu hydrogel properti surfacenetwork function mode action bacteri captur adhesiongrowth antibacteri activ bacteri sens respect final provid insight differ strategi develop multifunct hydrogel system help tackl manag understand bacteri infect antimicrobi resist also note strategi highlight review adapt cell type therefor like find applic beyond field microbiolog | D020100;D001424 | T047;T122 |
36,222,595 | salvia hispanica l chia seed improv liver inflamm endotheli dysfunct experiment model metabol syndrom purpos present studi analyz liver inflamm endotheli dysfunct experiment model metabol syndrom ms induc chronic administr sucros rich diet srd evalu effect chia seed therapeut strategi male wistar rat fed refer diet rd month srd month latter group random divid two subgroup one subgroup continu receiv srd month fed srd whole chia seed incorpor sourc dietari fat next month srd chia result show rat fed srd long period time develop dyslipidemia hyperglycemia inflamm endotheli dysfunct hepat nas il nfb p pai f express well mpo activ signific increas il express signific decreas accompani increas plasma il tnf level rat fed srd addit serum liver nitric oxid level nitric oxid synthas nos signific increas srd group addit signific increas hepat ino express posit correl liver nfb p found observ signific increas hepat intercellular adhes molecul icam negat correl liver nrf found administr chia seed month revers dyslipidemia hyperglycemia inflamm endotheli dysfunct liver tissu nas il il nfb p pai f express mpo activ normal serum liver nos level hepat ino express decreas last one associ decreas liver nfb p level hepat icam normal negat correl liver nrf level studi show new aspect liver inflamm endotheli dysfunct dyslipidem insulin resist rat chronic fed sucros rich diet addit demonstr new properti molecular mechan associ benefici effect inflamm endotheli dysfunct chia seed therapeut strategi | D027544;D024821;D050171;D006505;D006943 | T047;T046;T002;T033 |
36,222,593 | decreas burden revis hip replac despit substanti rise preval regist base analysi finland incid thr oper establish littl known preval ratio annual number revis thrs total number thrs general popul combin data nationwid regist calcul annual preval thrs revis burden caus thr survivor finland | D019644;D006622 | T061;T074 |
36,222,558 | rmg databas chemic properti predict reaction mechan generat rmg databas chemic properti predict present rmg databas consist curat dataset estim accur predict paramet necessari construct wide varieti chemic kinet mechan dataset estim most publish enabl predict thermodynam kinet solvat effect transport properti thermochemistri predict rmg databas contain librari thermochem paramet combin entri group addit scheme type correct includ radic polycycl surfac absorpt correct total curat group paramet graph convolut neural network train use transfer learn set dft calcul high qualiti valu correct scheme solvent solut effect import thermochemistri liquid phase avail includ tabul valu pure solvent common solut group addit scheme predict properti arbitrari solut kinet estim databas contain librari kinet paramet contain combin reaction contain rate rule scheme reaction class train curat train reaction addit librari estim avail transport properti inform easili access graphic user interfac https rmgmitedu bulk fli use facilit interfac direct rmg python packag instal anaconda rmg databas provid kineticist easi access estim mani paramet need model analyz kinet system help speed facilit kinet analysi enabl easi hypothesi test pathway provid paramet model construct provid check kinet paramet sourc | D008956 | T170 |
36,222,539 | method recombin product purif peptid sumo peptid intein fusion protein protect degrad heterolog express escherichia coli common use method produc ribosom synthes peptid studi general requir express target protein affin fusion tag follow isol fusion protein cellular lysat affin purif final remov fusion tag purif desir peptid sometim howev fusion protein may degrad recombin express e coli recent report express system sandwich target peptid n termin small ubiquitin like modifi sumo protein c termin intein sumo peptid intein spi fusion protein protect central peptid degrad lead improv peptid yield purif report detail clone express isol procedur spi fusion system comment condit optim differ peptid obtain maxim yield construct wiley period llc basic protocol clone construct spi gene basic protocol express spi fusion protein e coli bl de support protocol optim express induct condit basic protocol isol purif spi fusion protein chitin column altern protocol isol purif spi fusion protein without chitin | D004926;D047668 | T007;T123;T116 |
36,222,520 | iron catalyz sulfonylthiocyan unsatur amidesest via insert sulfur dioxid iron catalyz four compon sulfonylthiocyan unsatur amidesest tmsncs aryldiazonium tetrafluorobor sulfur dioxid sogen demonstr protocol character mild reaction condit good function group compat broad substrat scope good excel yield provid feasibl method prepar thiocyan sulfon compound preliminari mechan investig show radic pathway may involv process | D004952;D000577 | T109 |
36,222,519 | lyssavirus p protein isoform diverg signific subcellular interact under mechan interferon antagon viral hijack microtubul mt depend transport well understood sever virus also express discret mt associ protein vmap potenti modul mt depend process host cell specif role vmap mt interact includ subvers antivir respons p isoform p protein rabi virus rabv genus lyssavirus mediat mt depend antagon interferon ifn depend signal transduc activ transcript stat signal p also undergo nucleocytoplasm traffick inhibit stat dna bind indic intranuclear role multiprong antagonist strategi mt associationstat antagonist function p correl pathogenesi indic potenti therapeut target howev key question remain includ whether p protein isoform interact mts relationship interact pathogenesi extent conserv p mt interact divers pathogen lyssavirus use super resolut microscopi live cell imag immun signal analys find multipl p protein isoform associ mts associ correl pathogenesi furthermor p protein differ lyssavirus exhibit variat intracellular local phenotyp associ stat antagonist function wherebi p mt associ conserv among lyssavirus phylogroup phylogroup ii nucleocytoplasm local vari p protein phylogroup within phylogroup ii nevertheless diverg p protein retain signific ifn antagonist function indic adapt favor differ inhibitori mechan mt interact import phylogroup virus import lyssavirus includ rabi virus caus rabi progress encephalomyel almost invari fatal effect antivir symptomat infect effect applic current vaccin limit area endem rabi caus death per year viral subvers host cell function includ antivir immun critic diseas isoform lyssavirus p protein central virus host interfac underpin immun evas show specif cellular interact p protein isoform involv immun evas vari signific differ lyssavirus indic distinct strategi evad immun respons find highlight divers virus host interfac import consider develop pan lyssavirus therapeut approach | D018114;D011818;D011820;D011819 | T047;T121;T109;T129;T005 |
36,222,506 | angiotensin convert enzym ace express pediatr liver diseas membran protein angiotensin convert enzym ace gain notorieti receptor sever acut respiratori syndrom coronavirus prior evid shown ace express within liver function fulli discern util novel methodolog assess ace express pediatr immun mediat liver diseas better understand presenc liver diseas role infect covid stain liver tissu ace specif immunofluoresc antibodi analyz via confoc microscopi comput deep learn base segment model identifi nuclei cell allow quantif mean cellular cytosol immunofluoresc spatial transcriptom provid high throughput gene express analysi tissu determin cellular composit ace express ace plasma express quantifi via enzym link immunosorb assay high ace express seen apic surfac cholangiocyt lower express within hepatocyt cytosol nonparenchym cell p children liver diseas higher ace hepat express pediatr control tissu p adult control tissu higher express pediatr control p plasma ace found statist differ sampl spatial transcriptom identifi cell composit ace express spot contain antibodi secret cell result show ace express throughout liver strongest local cholangiocyt membran machin learn use rapid identifi hepat cellular compon histolog analysi ace express liver may increas pediatr liver diseas futur work need better understand role ace chronic diseas acut infect | D000086382;D008107 | T047;T067;T033 |
36,222,504 | diagnost util idh r immunohistochemistri tall cell carcinoma revers polar breast tall cell carcinoma revers polar tccrp rare histolog type low grade breast cancer consist tall columnar cell revers nuclear polar character frequent idh mutat herein report case tccrp sequenc analys idh gene immunohistochem examin use monoclon antibodi cb idh r idh r mutat detect resect tumor rs tumor rt tumor presenc mutat confirm idh r immunohistochemistri tumor cell tccrp show strong diffus stain antibodi idh r case tumor tissu core needl biopsi sampl collect differ day also immunohistochem posit idh r result indic idh r immunohistochemistri suitabl detect tccrp resect biopsi sampl addit literatur review reveal rs rt account idh mutat tccrp suggest cb react rs rt like sensit idh mutat tccrp among mani avail antibodi idh r furthermor combin antibodi idh r could effect detect tccrp mutat howev import note idh r immunohistochemistri absolut idh wild type found small proport case case idh mutat tccrp may harbor rare subtyp r cover avail antibodi | D007521;D002277 | T191;T126;T116 |
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