PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,222,503 | tumor elimin cluster microrna mir mir via noncanon activ jnk signal jnk signal play critic role tumor promot tumor suppress identifi cluster microrna mirna mir mir novel tumor suppressor mirna specif elimin jnk activ tumor drosophila show slight effect normal tissu growth mir mir strong suppress growth multipl tumor model includ malign tumor caus ras activ cell polar defect mechanist mirna common target mrna e ubiquitin ligas ring finger protein rnf found rnf promot degrad tankyras tnks adp ribos polymeras promot jnk activ noncanon manner thus downregul rnf mir mir lead hyper enhanc jnk activ data show jnk activ essenti tumor growth elev mir mir overactiv jnk signal lethal level via noncanon jnk pathway thus elimin tumor provid new mirna base strategi cancer | D035683;D009369 | T191;T123;T114 |
36,222,500 | stereoselect total synthesi formosanol tsugacet methyl conidendr first enantioselect total synthesi aryltetralin lignan acet formosanol tsugacet methyl conidendr enantiom accomplish basi pd catalyz asymmetr allyl cycloaddit key step six stereoisom lignan acet synthes via step sequenc overal yield vitro cytotox sever cancer cell preliminarili examin obtain six stereoisom lignan acet | D000080;D017705 | T109 |
36,222,498 | klc shape axon arbor develop mediat adult behavior develop elabor polar neuron morpholog requir precis regul transport cellular cargo motor protein kinesin kinesin numer cellular cargo must deliv uniqu neuron compart process motor select transport deliv cargo regul neuron morphogenesi poor understood although cargo bind kinesin light chain klc subunit contribut specif work implic one subunit klc essenti regul axon branch arbor pattern sensori neuron develop use live imag approach klc mutant zebrafish show klc requir stabil nascent axon branch proper microtubul mt dynam endosom transport furthermor klc requir proper tile peripher axon arbor klc mutant peripher axon show abnorm fascicul behavior characterist central axon result suggest klc pattern axon compart help establish molecular differ central peripher axon final find klc mutant larva hypersensit touch adult show anxieti like behavior novel tank test implic klc new gene involv stress respons circuit | D016547;D015027 | T126;T123;T116;T013 |
36,222,491 | workplac hazard health among inform employ domest worker citi unit state use four approach character worker pattern exposur character inform employ us domest worker dwer exposur pattern workplac hazard well singl hazard examin associ dwer work relat general health | D016273;D019567 | T037 |
36,222,484 | morpholog signatur actin organ singl cell accur classifi genet perturb use cnns transfer learn actin cytoskeleton play essenti role countless cell process cell divis migrat signal cancer cell cytoskelet dynam cytoskelet filament organ overal cell morpholog known alter substanti hypothes actin fiber organ cell shape may carri specif signatur genet signal perturb use convolut neural network cnns small fluoresc microscopi imag dataset retin pigment epitheli rpe cell tripl negat breast cancer tnbc cell identifi morpholog signatur cancer cell use transfer learn approach cnns could train accur distinguish normal oncogen transform rpe cell accuraci better singl cell level furthermor cnns could distinguish transform cell line differ oncogen mutat could also detect knockdown cofilin tnbc cell indic singl oncogen mutat cytoskelet perturb produc uniqu signatur actin morpholog applic local interpret model agnost explan lime method visual interpret cnn result reveal featur global actin structur relev cell classif task interest mani featur support previous biolog observ actin fiber organ thus sensit marker cell ident identif perturb could use assay cell phenotyp includ diseas state | D000199;D064726 | T191;T123;T116 |
36,222,482 | stereodiverg synthesi z e sulfonylacrylamid via tandem difunction alkyn sulfin isocyanid stereoselect difunction termin intern alkyn various sulfin isocyanid achiev prepar z e sulfonylacrylamid z sulfonylacrylamid generat via one pot process involv reaction termin alkyn sulfin isocyanid presenc iodin sequenti manner e sulfonylacrylamid prepar two step synthesi via palladium ii catalyz addit isocyanid e iodovinylsulfon synthes alkyn | D000480;D007455 | T121;T109;T123;T196 |
36,222,481 | physiolog signatur chang honeybe central complex wing flap mani kind locomot abil insect includ flight control spatial orient memori posit memori angl inform integr polar light guidanc consid relat central complex howev evid still suffici support conclus aspect neural basi locomot form wing flap littl known pattern chang brain activ central complex movement analyz chang honeybe neuron popul fire activ central complex optic lobe perspect energi nonlinear chang although specif function central complex remain unknown evid suggest neural activ chang remark wing flap delta rhythm domin togeth data reveal fire activ neuron popul optic lobe show reduct complex wing flap elucid brain activ chang flap period insect promot understand neuro mechan insect locomotor control thus inspir fine control insect cyborg | D005426;D008954 | T075;T040 |
36,222,477 | multifunct au modifi ti c mxene photothermalenzym dynamicimmun synergist therapi ti c mxene base composit provid multifunct interfac diagnosi treatment tumor herein propos multifunct nanoplatform base ti c mxene au nanocomposit combin phototherm properti peroxidas like activ accomplish synergist phototherm therapi ptt enzym dynam therapi edt accompani photoacoust pa thermal dual mode imag vivo furthermor ptt induc immunogen cell death edt promot cell apoptosi facilit dendrit cell dc matur cell infiltr tumor basi antibodi ox ox util contribut immun therapi revers immunosuppress tumor microenviron activ cd cd cell summari triun pttedtantitumor immun therapi achiev combin ti c mxene au nanocomposit ox possess sever strong featur good biocompat nir control target signific cancer cell kill satisfactori biosafeti vitro vivo work might highlight promis applic mxene base nanoplatform cancer therapi | D053761;D009369;D053758 | T191;T073 |
36,222,465 | outstand bio tribolog perform induc synergist effect diamond nanosheet coat silk fibroin due excel biocompat outstand mechan properti high strength weight ratio good corros resist titanium ti alloy extens use implant materi artifici joint howev ti alloy suffer poor wear resist result consider short lifetim studi demonstr chemic self assembl novel two dimension diamond nanosheet coat ti alloy combin natur silk fibroin use novel lubric fluid synergist result excel friction wear perform linear reciproc slide test verifi coeffici friction wear rate diamond nanosheet coat silk fibroin lubric reduc respect compar uncoat ti alloy water lubric lubric mechan newli design system reveal detail analysi involv microstructur chemic chang outstand tribolog behavior attribut establish artifici joint lubric induc cross bind diamond nanosheet silk fibroin addit excel biocompat lubric system verifi cell viabil altogeth pave way applic diamond coat artifici ti joint implant | D005349 | T123;T116 |
36,222,451 | phd complet older peopl dentist practic oral health oral health care thesi describ oral health communiti dwell older peopl visit dental practic seen perspect older person dentist addit oral health care provid dentist barrier may perceiv describ older peopl still visit dentist relat healthi well educ dentat grow older face increas health problem increas medic use oral health issu age seem tip point dentist main provid curat care focus preserv dentit assess oral health older peopl appear assess oral health posit dentist barrier provis oral health care main relat health problem misunderstood behaviour poor daili oral hygien older peopl earlier identifi barrier appear relat knowledg practic condit financi reimburs work | D003815;D009909 | T097;T033 |
36,222,450 | periap lesion alway inflamm periap radiopac periap radioluc radiopac mix lesion identifi radiograph usual caus inflamm endodont origin howev periap lesion sometim caus primari bone patholog predomin manifest apic teeth various intraoss lesion also project across apic creat impress causal relat teeth incorrect diagnosi lead endodont treatment carri unjustifi thorough detail anamnesi complet extra intraor clinic examin care studi radiograph imag lead correct diagnosi case regard knowledg differenti diagnosi periap lesion essenti articl focus appar periap radiopac differenti | D014070 | T023 |
36,222,449 | portabl x ray devic techniqu imag qualiti regul portabl intraor x ray devic market altern convent wall mount devic basi recent clinic trial diagnost qualiti portabl appear measur convent devic ce certifi portabl devic use rectangular collim backshatt radiat shield adapt techniqu result beam parallel ground oper exposur stay well within dose limit howev dose oper higher use convent devic therefor netherland guidelin restrict use portabl devic ambul use outsid dental clinic deploy addit radiat protect measur presum advantag increas control exposur due proxim patient would substanti research restrict use could reconsid dentist awar onlin avail non ce certifi portabl intra oral x ray devic potenti unsaf | D011835;D011861 | T061;T060 |
36,222,448 | measur tooth wear regular intra oral scanner still futur alreadi possibl quantit tooth wear measur method increas import measur tooth wear progress radboud univers medic center develop protocol measur height volumetr differ regular scan intra oral scan made patient tooth wear superimpos assess reliabl precis well intra inter rater precis protocol test test perform determin structur random error find indic method precis enough measur height differ patient sever tooth wear progress tooth wear interv longer year method precis enough measur volumetr chang | D019217;D057085 | T020;T037 |
36,222,447 | patient specif joint prothesi ankylot temporomandibular joint year old woman suffer sever obstruct sleep apnea osa refer depart oral maxillofaci surgeri depart due progress limit mouth open chronic pain temporomandibular joint base clinic radiolog examin patient diagnos recurr ankylosi temporomandibular joint patient treat patient specif implant temporomandibular joint combin le fort osteotomi genioplasti includ genioglossus advanc treatment may advantag patient lower recurr rate ankylosi improv maxim mouth open pain reduct improv aesthet result | D020181;D013705;D020254 | T047 |
36,222,445 | interest case thigh cellul streptococc sex syndrom streptococc sex syndrom rare recognis associ recurr pubic genit thigh cellul sexual intercours pelvic surgeri radiat lymphat dysfunct may play role aetiolog syndrom describ case streptococc sex syndrom describ suggest manag strategi | D002481;D013290 | T047;T046 |
36,222,442 | improv protocol stereoselect synthesi glycosyl fluorid acyl thioglycosid safe oper simpl protocol prepar glycosyl fluorid present demonstr precis combin xtalfluor n bromosuccinimid et nhf mediat facil high yield diastereoselect convers acyl thioglycosid tran glycosyl fluorid key role reagent dissect work impact interplay fluorin stereoselect | D013865 | T109 |
36,222,441 | noncoop guest bind metal free schiff base macrocycl salphen base n n macrocycl wide explor uniqu chemic topolog properti follow metal ion coordin despit vast differ reactiv coordin counterpart fewer studi focus metal free salphen macrocycl investig bind schiff base macrocycl host contain central crown like caviti two moieti macrocycl strong bind spheric cation guest k dcmmecn robust bind shown k na follow li rb steric demand cation guest like dibenzylammonium dba show almost bind bind pocket slight smaller crown result bind outsid caviti provid scaffold appropri complex two host molecul sandwich guest host guest complex follow noncoop bind model success bind event less like previous unlik coordin version bind | D043844 | T109 |
36,222,428 | total synthesi ceforalid b cephanolid b ceforalid b cephanolid b benzenoid cephanolid diterpenoid possess pentacycl skeleton contain three c c substitu pattern differ benzyl oxid state olefin electrocyclizationoxid aromat cascad verifi diverg access three c c pattern benzyl aerob oxid enabl co oac hobromid saltopphn hydroxyphthalimid system develop deliv expect site select differ oxid state diverg strategi total synthesi ceforalid b cephanolid b accomplish | D001965;D004224 | T109;T197 |
36,222,426 | light respons molecular releas cubosom use swell squeez lattic control stimuli respons materi crucial advanc control deliveri system drug catalyst lyotrop liquid crystal llcs well defin intern structur suitabl entrap small molecul broken low viscos dispers aid applic deliveri system work demonstr first exampl light respons cubic llc dispers cubosom use photoswitch amphiphil enabl extern control llc structur subsequ demand releas entrap guest molecul azobenzen photosurfact azop contain neutral tetraethylen glycol head group azobenzen alkyl tail combin wt monoolein water system creat llc phase homogen bulk llc form dispers particl nm diamet intern bicontinu primit cubic phase seen use small angl x ray scatter cryo transmiss electron microscopi notabl increas azop concentr lead swell cubic lattic offer method tune intern nanoscal structur upon uv irradi azop within cubosom isomer within second turn lead squeez cubic lattic decreas lattic paramet squeez mechan success har enabl phototrigger releas trap nile red guest molecul cubosom structur minut abil control intern structur llc dispers use light dramat effect retent entrap molecul suggest system may huge potenti next generat nanodeliveri | D000080762;D050866 | T104;T073 |
36,222,425 | molecular insight bind linear polyethylenimin singl strand dna use raman spectroscopi quantit approach establish polymer vector polyethylenimin pei bind packag nucleic acid cargo vital toward develop efficaci cost effect gene therapi develop molecular level pictur dna bind examin raman spectra pei report local chemic environ find intens raman band locat cm region deriv vibrat signific ch scissor nh bend charact raman band deriv vibrat show profound intens chang depend local dielectr environ hydrogen bond interact secondari amin group polym use band spectroscop marker assess bind low molecular weight pei singl strand dna ssdna analysi raman spectra suggest pei primarili bind via electrostat interact phosphat backbon induc condens ssdna addit confirm find conduct molecular dynam simul expect spectral correl determin enabl futur studi investig import gene deliveri activ includ pei interact cellular membran facilit cargo intern cell | D011094;D013059 | T059;T109;T130;T070 |
36,222,424 | mechan ginger process product treatment estradiol valer coupl oxytocin induc dysmenorrhea mice via regul trp ion channel mediat erk nf b signal pathway ginger rhizoma zingiberi rz use food spice supplement flavor agent edibl herbal medicin character pungenc aroma rich nutrient remark pharmacolog effect use tradit medicin clinic treat diseas symptom cold headach primari dysmenorrhea pd china varieti process product rz use herbal medicin bake ginger bg ginger charcoal gc treat differ diseas symptom howev molecular mechan therapeut effect rz process product rzpps includ bg gc pd well character moreov whether transient receptor potenti trp ion channel involv process clear present studi uhplc q tof ms adopt analys differenti qualiti marker dqms rz rzpps addit differenti metabolom dms acquir rz rzpps treat estradiol valer coupl oxytocin induc pd mous uterus use untarget metabolom um correl analysi dqms dms also conduct benzenoid lipid lipid like molecul main dqms rz rzpps rz rzpps found improv patholog status uterus pd mous signific decreas serum level e pgf txb remark increas level prog keto pgf moreov rz rzpps allevi pd mice via regul trp ion channel mediat erk nf b signal pathway result indic therapeut effect rz rzpps pd may mediat regul trp ion channel mediat erk nf b signal pathway provid refer develop new dietari supplement medicin | D020939;D004365;D010946 | T121;T123;T002 |
36,222,423 | whole greater sum part scope review activ base therapi pair spinal cord stimul follow spinal cord injuri spinal cord injuri sci result motor autonom impair negat affect independ qualiti life increas morbid mortal despit emerg evid support benefit activ base train spinal cord stimul two distinct intervent sensorimotor autonom recoveri combin effect modal current uncertain scope review evalu effect pair intervent exercis spinal neuromodul improv sensorimotor autonom function individu sci four electron databas search peer review manuscript medlin embas cinahl ei compedex engin villag data independ extract two review use pre establish extract tabl total studi repres particip includ review conduct within past year two studi random control studi studi case case seri design compar activ base train alon spinal cord stimul combin activ base train improv walk voluntari muscl activ augment improv lower urinari tract bowel rest metabol rate peak oxygen consumpt thermoregulatori function spinal neuromodul combin use depend therapi may provid greater neurorecoveri induc long term benefit motor autonom function beyond capac tradit activ base therapi howev evid combin approach limit consensus outcom measur optim protocol paramet includ stimul set futur larg scale random trial pair intervent warrant investig preliminari find | D062187;D013119 | T061;T037 |
36,222,421 | mechan initi tubulin nucleat phase tubulin nucleat high frequent event microtubul mt dynam poor understood work character structur chang initi nucleat phase dynam tubulin use size exclus chromatographi elut tubulin dimer assembl buffer solut free glycerol tubulin aggreg enabl us start well defin initi thermodynam ensembl isol dynam tubulin dimer short oligom follow temperatur increas time resolv x ray scatter cryo transmiss electron microscopi initi nucleat phase reveal isodesm assembl mechan one dimension tubulin oligom dimer ad andor remov one time lead suffici stabl two dimension dynam nanostructur requir mt assembl substanti amount tubulin octam accumul two dimension lattic appear subcrit assembl condit observ slower isodesm assembl mechan concentr oligom insuffici form multistrand nucleus requir mt format | D014404;D008870 | T026;T123;T116 |
36,222,418 | citrat enrich western diet reduc weight gain via brown adipos tissu without resolv diet induc insulin resist mice citrat major compon process food appear either preserv flavor enhanc concentr limit citrat consum larg quantiti worldwid princip ultra process food upf upf encount western diet rich satur fat sucros consumpt direct associ mani condit obes diabet among other administ high fat high sucros hfhs diet mice enrich citrat mg g diet aim simul upf citrat consumpt result show citrat enrich prevent hfhs induc lipid deposit liver adipos tissu anim moreov treatment induc mitochondri biogenesi white adipos tissu via upregul pcg result citrat enhanc upregul ucp suggest brown white adipos tissu nevertheless citrat enhanc diet prevent hfhs induc insulin resist caus liver inflamm injuri altogeth result clear show associ upf consumpt excess dietari citrat caus harm effect associ non obes relat liver inflammatori diseas insulin resist | D007333 | T046 |
36,222,417 | investig photosensit koneramin cell imag therapeut applic photophys properti anthracen append koneramin l analyz util chemosensor select detect cd zn complex induc inhibit pet photo induc electron transfer chelat nitrogen atom excit state anthracen moieti result fluoresc turn signal upon bind cd zn confoc microscop imag studi perform mcf cell valid compound potenti use detect cd zn insid cell cadmium complex exhibit uniqu bactericid activ clinic relev human pathogen excel activ multidrug resist aureus make complex use new easili synthesiz antibiot cadmium complex l cdcl cytotox vero cell select index exhibit concentr depend bactericid kill non interact sever clinic approv standard drug exhibit prolong post antibiot effect pae aureus atcc possess antibiofilm activ | D002104;D055624 | T007;T131;T196 |
36,222,415 | facil construct c n disulfon amino pyrazol iodin catalyz cascad reaction green facil synthesi previous unreport c n disulfon amino pyrazol establish iodin catalyz cascad reaction easili access sulfonyl hydrazid ketonitril sodium sulfin divers c n disulfon amino pyrazol could obtain yield methodolog featur green mild condit broad substrat scope effortless work | D011720;D007455 | T121;T109;T123;T196 |
36,222,413 | tumor target oxid stress nanoamplifi anticanc nanomedicin immunostimul activ compar normal cell cancer cell suscept insult prooxid generat ros reactiv oxygen speci scaveng antioxid glutathion gsh cancer cell undergo immunogen cell death icd elev oxid stress herein report ration design f sspbca nanoparticl tumor target prooxid generat ros scaveng gsh simultan cooper amplifi oxid stress lead icd prooxid f sspbca nanoparticl compos disulfid bridg gsh scaveng dimer prodrug sspb self assembl form nanoconstruct encapsul ros generat bca benzoyloxi cinnamaldehyd f sspbca nanoparticl signific elev oxid stress kill cancer cell also evok icd featur releas crt calreticulin hmgb high mobil group box adenosin triphosph atp anim studi reveal f sspbca nanoparticl accumul tumor preferenti suppress tumor growth effect result studi demonstr prooxid mediat oxid stress elev high effect strategi kill cancer cell select even evok abund icd anticip oxid stress amplifi f sspbca nanoparticl hold tremend translat potenti tumor target icd induc anticanc nanomedicin | D011355;D000970;D009369;D053758 | T073;T120;T121;T191;T109 |
36,222,412 | facilit ab initio qmmm free energi simul gaussian process regress deriv observ combin quantum mechan molecular mechan qmmm free energi simul synthes accuraci ab initio ai method speed semiempir se method cost effect qm treatment remain long stand challeng work present machin learn facilit method obtain aimm qualiti free energi profil effici semm simul particular use gaussian process regress gpr learn energi forc correct need semm match aimm result molecular dynam simul forc match enabl model includ energi deriv observ target extend kernel formal demonstr effect method solut phase n menshutkin reaction use ammm blyp g p mm base target level respect train configur sampl along minimum free energi path mfep result gpr model reduc averag energi error ammm kcal mol sampl test set averag forc error qm atom decreas kcal mol free energi sampl gpr correct appli gprmm produc free energi barrier kcal mol reaction free energi kcal mol closer agreement aimm benchmark experiment result | D011789;D056004 | T066;T170;T044 |
36,222,411 | recent advanc luminesc metallacyclesmetallacag biomed imag cancer therapi small molecul metal base drug shown great achiev preclin clinic applic particular platinum base antitumor drug well establish current cancer chemotherapi howev face problem poor select sever toxic side effect strong drug resist poor uptakeretent vivo difficulti monitor therapeut effect real time larg limit widespread use clinic applic metallacyclesmetallacag form coordin driven self assembl high emit ligand solv problem import acceptor chemotherapeut properti metallacyclesmetallacag combin luminesc ligand achiev combin chemotherapi imag contrast agent multifunct therapeut platform review provid insight paradigm self assembl metallacyclesmetallacag biolog applic mono chemotherapeut drug excel fluoresc imag contrast agent multifunct therapeut platform | D000970;D009369 | T121;T109;T191 |
36,222,410 | self power edibl defrost sensor improp freez food caus food wast negat impact environ work propos devic detect defrost event coupl temperatur activ galvan cell ionochrom cell activ releas ion current flow compon sensor fabric simpl low energi consum procedur edibl materi galvan cell oper aqueous electrolyt solut produc current temperatur freez point solut ionochrom cell exploit current generat defrost releas tin ion form complex natur dye caus color chang therefor sensor provid inform defrost event temperatur sensor react tune c devic thus flexibl use suppli chain sensor measur length exposur threshold temperatur detector provid signal exposur threshold temperatur devic ensur frozen food handl correct safe consumpt sensor could use worker suppli chain detector could use end consum ensur food proper frozen whole suppli chain | D005502;D012037 | T057;T168 |
36,222,408 | control becom habitu earli learn novel motor skill peopl perform task repeat behavior becom habitu inflex chang goal structur task although habit hypothes key aspect motor skill acquisit littl empir work investig relationship skill habit better understand relationship examin whether peopl behavior would becom habitu learn challeng new motor skill maneuv screen cursor nonintuit bimanu map hand cursor posit particip practic use map day alter map hand cursor assess whether particip could flexibl adjust behavior would habitu persist perform task way origin learn found particip behavior becam habitu within day practic point still relat unskil practic led improv skill alter strength habitu behavior data demonstr motor skill becom habitu relat littl train nevertheless improv practic suggest build habit earli learn may crucial step acquir new motor skill new noteworthi habit motor skill often thought deepli relat studi empir examin relationship two present evid habit emerg earli learn long motor skill fulli learn result suggest habit may play integr role learn perform motor skill even earli stage acquir new skill | D009048;D007858 | T061;T041;T040;T062 |
36,222,405 | transpos poem written medit care uphold abolit valu build safeti repair need revolut within arm reach health narrat poem describ person see world burn remain commit tend hope heart other share archiv remark moment recognit two artist stori attend virtual black communiti circl year ago friend lili share collag artwork one among titl spill imag among mani spectacular piec immedi struck spirit prompt recal poem written sever month spirit call respons offer poem communiti extend metaphor spill shift context spark dialogu mean us practic transpos chang place respect field lili nimo ngaruiya black kenyan american queer artist educ black liber seeker lili watercolor collag piec reflect emot black womanhood journey explor fear desir imag select root intuit restructur revis reimagin world within piec feel complet imag textur pattern lili aim creat univers black femm exist fulli view origin version poem see supplement materi section articl onlin | D001154;D000072339 | T098;T090 |
36,222,404 | relat poem recollect childhood reconnect rememb mani lesson learn plant relat reflect tradit medicin heal us hold us physic emot use frame relat come indigen scholar framework relate kincentr understand relationship emphas import nonhuman relat health food resourc relat engag reciproc relationship relationship transform us rais us heal us view origin version poem see supplement materi section articl onlin | D007858;D011037 | T061;T041;T170;T062 |
36,222,403 | thing nt know feel want get black woman public health profession first unlik public health dataset separ race gender nt know life way black woman second educ public health profession get decid think race racism classroom research nt know life without remind black treat accord explain grew believ need hide shrink get dub profession third anti black call codeswitch feel kind way hoop braid nail art predomin white space sinc decid carv space youth show unapologet take space experi allow design youth program contribut literatur way affirm ident amplifi voic despit exhaust ongo expect teach everyon racism target racism one thing get love black woman public health view origin version poem see supplement materi section articl onlin | D063505;D011634 | T054;T091 |
36,222,402 | grow tire statist poem autoethnopoet explor experi vitro fertil repetit offer throughout poem creat counter narrat ritual joy often stigmat shroud complex phenomenon poem amplifi salienc embodi knowledg public health quantit one seek situat ivf within reproduct birth justic movement view origin version poem see supplement materi section articl onlin | D005307;D012935 | T061;T078;T010;T080 |
36,222,401 | adjust adult spine aka backbon compos segment separ segment incap anim bodi communiti color low incom communiti margin group repres backbon health equiti research enterpris liter exist without bodi subject face structur inequ often research believ break bodi discret segment somehow anim bodi literatur capabl heal whole us poem counternarr enact public health critic race praxi principl voic disciplinari self critiqu engag spine metaphor name render visibl epistem symbol violenc prop public health bodi evidenceknowledg challeng field domin knowledg product paradigm eg positivist reduction draw attent settlercoloni racial capitalist extractivist logic racial health equiti discours domin narrat produc most white scholar health equiti tourist often use complex statist techniqu complet secondari quantit analys health communiti never step singl foot paradigm score researcherspractition led believ somehow come know us via variabl model alon poem suggest anyth els model practic need adjust warrant greater degre ethic scrutini historicallypres afford view origin version poem see supplement materi section articl onlin | D000069576;D011634 | T091;T080 |
36,222,400 | flesh poem invit reader contempl theme immigr parent caregiv age motherdaught relationship view origin version poem see supplement materi section articl onlin | D000375 | T040;T033 |
36,222,374 | surfac modif ti surfac nanoscal bio mof improv biocompat osteointegr vitro vivo biocompat osteointegr implant high desir orthoped dentistri applic synthesi coat ideal biocompat osteogen effect carri practic signific improv bio inert pure ti implant metal organ framework mof effect surfac modif agent bone regener applic bio mof classic type biofriend mof bio deriv constitut possess biocompat osteogen potenti result zn core adenin ligand studi bio mof coat multipl concentr synthes alkali heat treat ti cytocompat osteogen properti systemat examin vitro vivo coat character confirm success synthesi bio mof coat coat exhibit advanc thermost excel biocompat stabl zn releas regul express osteogenesi relat gene protein furthermor bio mof coat ti implant enhanc earli osseointegr bone implant interfac studi demonstr promis potenti bio mof coat osteogen effect surfac modif bone tissu engin | D014025;D000073396 | T109;T196 |
36,222,371 | know tail method quantif heterogen bacteri popul use singl cell mic profil sever non heal infect often caus multipl pathogen genet variant pathogen exhibit differ level antibiot resist exampl polymicrobi diabet foot infect doubl risk amput compar monomicrobi infect although infect lead increas morbid mortal standard antimicrobi suscept method design homogen sampl impair quantifi heteroresist propos droplet base label free method quantifi antibiot respons entir popul singl cell level use pseudomona aeruginosa staphylococcus aureus sampl confirm shape profil inform coexist divers bacteri subpopul size antibiot heteroresist profil could therefor indic outcom antibiot treatment term size remain subpopul moreov studi phenotyp variant aureus strain confirm profil use identifi toler subpopul small coloni variant associ increas risk develop persist infect therefor profil versatil instrument quantifi size bacteri subpopul within specimen well individu join heteroresist | D013211;D013203 | T007;T047 |
36,222,364 | chemic tool track perturb express sialic acid fucos monosaccharid biosynthesi glycan high conserv biolog process found domain life express cell surfac glycan increas recogn target therapeut intervent given role glycan major patholog cancer microbi infect herein summar contribut develop unnatur monosaccharid deriv infiltr alter express mammalian bacteri glycan therapeut applic | D005643;D009005 | T109 |
36,222,361 | microfluid base function materi new prospect wound heal beyond popular clinic research topic use function materi promot wound heal attract signific attent microfluid demonstr one promis versatil technolog fabric high perform function materi contribut physiolog stage wound heal respect review state art advanc develop microfluid function materi prepar key applic wound heal first elabor physiolog principl wound heal fundament microfluid categor depict varieti microfluid approach fabric function materi well tailor intern structur integr function wound treatment also summar recent repres microfluid base function materi facilit differ stage wound heal review conclud perspect futur direct challeng microfluid investig function wound heal materi emphas versatil clinic | D044085;D014945 | T090;T040 |
36,222,359 | effect particl size reduct combin cyclodextrin vitro dissolut vivo relat bioavail ginsenosid panax ginseng biolog effect ginsenosid limit low oral bioavail studi aim investig effect particl size reduct dispers dissolut bioavail ginsenosid ginseng fine ginseng powder fgp ultrafin ginseng powder ugp ultrafin ginseng powder cyclodextrin dispers ugpd prepar use planetari ball mill coars ginseng powder cgp control particl size morpholog hydrat thermal properti vitro dissolut behavior ginseng powder character relat oral bioavail ginsenosid protopanaxadiol ppd type protopanaxatriol ppt type determin rat model ugp ugpd display improv physiochem properti eg reduc particl size increas hydrat thermal properti total vitro dissolut ginsenosid ugpd higher cgp contrast ugp differ cgp import vivo pharmacokinet studi show relat bioavail total ginsenosid ugpd cgp set signific greater fgp ugp suggest dispers essenti preserv benefit ultrafin mill prevent ultra pulver induc agglomer particular ppd type ginsenosid show similar deglycosyl trend vitro vivo experi contrast deglycosyl state ppt type ginsenosid vari might attribut relat low abund glycosyl linkag potenti involv gut microbiota metabol conclus ultrafin mill combin dispers provid simpl scalabl manufactur process effect improv bioavail ginseng product | D005894;D036145;D047392 | T121;T109;T002 |
36,222,358 | revers light control fluoresc switch block polym graft carbon dot cellular imag novel type aggreg induc emiss aie nanoparticl carbon dot cds graft block polym tetraphenylethylen spiropyran n isopropylacrylamid cd g poli tpe co spa block nipam synthes cd g poli tpe co spa block nipam nanoparticl emit weak cyan fluoresc tetrahydrofuran show aie enhanc cyan fluoresc water solid film fluoresc cd g poli tpe co spa block nipam nanoparticl revers transform cyan red uvvis light irradi function revers fluoresc photoswitch import cd g poli tpe co spa block nipam nanoparticl low cytotox therefor use imag live cell | D011108;D002244 | T121;T104;T196;T122 |
36,222,352 | wickerhamomyc anomalus reliev wean diarrhea via improv gut microbiota redox homeostasi use piglet model wean stress common damag intestin barrier mammal result gut microbiota dysbiosi intestin ill even sever diarrhea probiot use nutrit strategi promot health human anim gut microbiota balanc wickerhamomyc anomalus appli probiot supplement wean piglet model investig impact growth perform antioxid capac inflamm respons intestin health supplement g kg cfu g w anomalus signific decreas feed convers ratio fcr allevi diarrhea improv appar total tract digest neutral deterg fiber ndf gross energi ge increas concentr total antioxid capac aoc catalas cat serum decreas concentr malondialdehyd mda pro inflammatori cytokin interleukin il serum import supplement w anomalus also improv gut microbiota decreas relat abund oxalobacteracea enrich relat abund lactobacillacea lactobacillus increas relat abund two speci lactobacillus helveticus delbrueckii conclus w anomalus could effect promot growth perform allevi diarrhea model wean piglet may relat improv antioxid activ anti inflammatori respons alter structur gut microbiota | D000069196 | T007;T001 |
36,222,348 | make liver cancer cell go argh recent studi missiaen et al uncov hepatocellular carcinoma hcc cell downregul urea cycl enzym reli uptak exogen arginin gcn kinas depend cell cycl arrest surviv result offer new avenu combinatori target liver cancer | D008113;D006528 | T191 |
36,222,345 | benefici interact pycnogenol indomethacin rat cyclooxygenas cox respons therapeut effect indomethacin inhibit cox enzym oxid stress respons gastro toxic effect report pycnogenol increas express cox suppress express rate cox oxid stress aim studi investig antiinflammatori activ indomethacin pycnogenol combin pi rat examin effect stomach tissu studi anti inflammatori activ investig carrageenan induc inflammatori paw edema albino wistar male rat effect stomach tissu perform appli previous method pi indomethacin pycnogenol best suppressor carrageenan inflamm oxid stress paw tissu respect group lowest cox activ paw tissu ic pic pc respect pic ic pc one best inhibit increas cox activ pycnogenol inhibit increas malondialdehyd decreas total glutathion cox stomach signific suppress format indomethacin ulcer experiment result show pycnogenol reduc toxic effect indomethacin stomach increas anti inflammatori activ benefici interact pycnogenol indomethacin suggest pi provid superior success treatment inflammatori diseas | D004487;D007213 | T121;T046;T109 |
36,222,344 | nanoparticl mediat deliveri system allevi format infect stone activ trpv infect stone constitut small intract group diseas urinari system studi explor potenti therapeut effect small activ rna ds encapsul chitosan chitosan western blot analysi verifi downregul trpv patient rat model infect stone well stimul ds trpv express mtt assay show chitosan mediat deliveri less cytotox ds compar liposom deliveri modifi invas assay reveal inhibitori effect chitosan bacteri invas normal rat kidney epitheli nrk e cell establish infect stone model perform intraves inject cfu proteus mirabili anim experi visibl stone obtain number live bacteria white blood cell urin show differ among infect rat time sacrific howev observ declin urin calcium ph suggest effect acidif overal studi provid evid protect effect chitosan abil regul urinari calcium acidifi urin inhibit bacteria invad renal epitheli cell thus serv import complementari therapi infect stone | D048271;D053758 | T121;T109;T073 |
36,222,343 | effect low high dose favipiravir ovarian reproduct function femal rat biochem histopatholog evalu favipiravir drug show antivir activ inhibit rna depend rna polymeras favipiravir caus sever advers effect high dose aim studi investig effect low high dose favipiravir ovarian reproduct function femal rat rat divid three group hg group healthi rat fav group rat administ mgkg favipiravir fav group rat administ mgkg favipiravir rat group favipiravir administ oral twice daili week six rat group euthan ovari remov oxid antioxid paramet measur ovarian tissu examin histopatholog remain anim kept breed anim receiv favipiravir increas oxid content decreas antioxid activ decreas histopatholog damag infertil gestat delay favipiravir treatment use caution especi women reproduct age | D000975;D014150 | T121;T044;T123;T039 |
36,222,342 | role sirt chang skelet muscl mitophagi induc hypox train aim explor role sirt regul skelet muscl mitophagi hypox train cblj mice random divid four group c group control ht group mice perform hypox train live environ oxygen concentr treadmil exercis normoxia week group mice subject intraperiton ip inject sirt inhibitor h triazol yl pyridin typ mgkg three time per week week tht group hypox train ht group ip inject typ group result show week hypox train could improv atp synthesi skelet muscl combin intervent typ inject hypox train sirt foxoa sod protein content still lower hypox train group hypox train improv negat effect sirt inhibit muscl pinkparkin signal studi demonstr sirt play key role mediat skelet muscl mitophagi hypox train result studi also provid first evid mitophagi caus hypox train might transduc sirt foxoa signal pathway | D063306;D056566 | T043;T126;T116 |
36,222,341 | cerium oxid nanoparticl modul liver x receptor short heterodim partner attenu liver steatosi steatohepat rat model postmenopaus obes studi aim investig effect cerium oxid nanoparticl ceo nps non alcohol fatti liver diseas postmenopaus obes under mechan adult femal rat alloc sham ovariectom ovx high fat high fructos dietf ovx hfhf ovx hfhf ovx ceo nps treat ceo hfhf ovx group ovx hfhf ovx rat present signific increas overal viscer obes dyslipidemia liver enzym serum malondialdehyd liver tnf tgf free fatti acid liver x receptor lxr express associ decreas serum total antioxid capac liver short heterodim partner shp express vs sham group also histomorphometr studi display signific higher score liver steatosi inflamm fibrosi paramet signific improv ceo nps treatment ceo hfhf ovx vs hfhf ovx rat thus ceo nps treatment amelior liver steatosi steatohepat fibrosi postmenopaus obes rat via allevi obes dyslipidemia modul liver gene involv lipid metabol lxr shp decreas liver lipogenesi besid antioxid anti inflammatori effect | D050171;D053758;D065626 | T047;T046;T073 |
36,222,340 | h pattern dgcr drosha dicer express rat suprachiasmat nuclei peripher tissu modul angiotensin ii studi focus regulatori interact circadian system renin angiotensin system control microrna mirna biosynthesi respons mirna biosynthet pathway select pre mirna clock gene angiotensin ii angii infus analys suprachiasmat nuclei scn liver kidney heart h cycl per exert rhythmic express profil analys tissu clock express show rhythmic pattern peripher tissu tissu specif respons angii dgcr express show tissu specif rhythm peripher tissu diminish heart kidney angii deliveri express pre mir c rhythmic studi peripher tissu pre mir express exert signific rhythm liver angii deliveri increas express pre mir c pre mir kidney conclud peripher oscil like exhibit rhythmic mirna biosynthesi respons angii tissu specif manner compar scn | D000804;D035683 | T121;T123;T116;T114 |
36,222,339 | role mechan ndstnulp regul right ventricular hypertrophi hypox pulmonari hypertens hypoxia lead hypox pulmonari hypertens hph caus right ventricular hypertrophi rvh rvh becom signific nonneglig public health issu world studi success establish hph rat model found rvh happen hph observ increas inflamm respons heart tissu hph induc rvh rat moreov increas n deacetylas n sulfotransferas ndst decreas nuclear local protein nulp found heart tissu hph induc rvh rat vitro cell experi show inhibit ndst express enhanc cell viabil reduc cell apoptosi allevi cardiomyocyt hypertrophi decreas inflamm increas phosphoryl akt level howev express ndst opposit effect aspect nulp revers effect ndst regul final found regul ndst reduc nulp express regul ndst increas nulp express studi confirm inhibit ndstnulp pathway might contribut attenu hph induc rvh mechan may relat reduct inflamm cardiomyocyt apoptosi akt phosphoryl | D006976;D017380 | T047;T046 |
36,222,338 | potenti use mirna diagnosi predict metastat lung carcinoma lung carcinoma top killer malign world earli diagnosi lung carcinoma signific improv patient surviv screen biomark peripher blood could detect patient earli stage diseas microrna mirna could possibl biomark nucleotid long singl strand rna molecul play import role post transcript regul gene activ individu mirna potenti regul gene respons cell prolifer differenti apoptosi regul cell cycl cooper pro oncogen tumor suppressor gene studi determin mirna express level individu sampl lung carcinoma patient healthi control group use revers transcript method follow qrt pcr express level investig mirna evalu qiagen geneglob data center softwar demonstr signific mir let g biomark lung carcinoma clinic stage studi also observ signific increas express mir mir distant metastasi stage signific decreas express mir n diseas group lung carcinoma patient n diseas repres diseas metastas ipsilater mediastin andor subcarin lymph node node investig mirna show clear potenti detect potenti resect n n local advanc n distant organ metastat lung carcinoma | D002277;D008175;D035683 | T191;T123;T114 |
36,222,337 | urotensin ii activ ferroptosi pathway circmir sertad promot activ vascular adventiti fibroblast vascular adventiti fibroblast vaf urotensin ii uii play import role vascular remodel diseas mechan uii vaf still unclear uii inhibit mir express regul circ express therebi promot sertad express uii signific promot generat ros mda hne reduc activ sod gst gr increas fe concentr inhibit gpx express circmir sertad uii ferroptosi induc erastin signific promot express sma collagen tgf vaf circ sirna mir mimic sertad sirna ferrostatin signific inhibit effect uii erastin cell activ co transfect circ sirna mir inhibitor mir mimic sertad overexpress vector uii still signific increas express sma collagen tgf transfect circ overexpress vector mir inhibitor sertad overexpress vector treat uii ferrostatin express sma collagen tgf still signific circ overexpress vector mir mimic mir inhibitor sertad sirna co transfect uii ferrostatin ad express sma collagen tgf signific increas therefor result indic uii promot activ vaf circmir sertadferroptosi pathway | D000079403;D035683 | T043;T123;T114 |
36,222,336 | integr bioinformat machin learn strategi reveal prdx key ferroptosi associ molecular biosignatur heart failur heart failur hf lead caus death public health problem global popul studi aim identifi valid ferroptosi relat biomark associ hf clinic medicin use bioinformat machin learn strategi weight co express network analysi wgcna appli screen modul gene analyz biolog function pathway ferroptosi associ gene fag hf determin machin learn algorithm use screen next multipl extern independ microarray use verifi molecular biosignatur simultan cibersort appli estim immun infiltr landscap combin result wgcna fag determin famb select machin learn strategi addit peroxiredoxin prdx final select key ferroptosi associ molecular biolog featur base multipl verif independ data set result infiltr enrich analysi believ prdx protect biomark relat ferroptosi hf may help provid new idea immunotherapi hf | D000079403;D006333 | T043;T046;T047 |
36,222,332 | synthesi properti oligodiaminogalactos bind type oligonucleotid duplex recent doubl strand oligonucleotid therapeut type duplex structur short interf rnas gain consider attent report synthesi cation oligosaccharid select bind type oligonucleotid duplex particular oligodiaminogalactos odag strong stabil effect type oligonucleotid duplex howev effici synthet method establish odag properti odag investig mer crucial problem synthesi side reaction p methoxybenzyl pmb protect group hydroxi group paper benzyl bn group chosen protect group hydroxi group suppress side reaction protect group yield glycosyl reaction signific improv moreov optim condit deprotect bn group allow effici synthesi fulli deprotect odag odag mer mer synthes first time addit systemat investig effect odag properti sever oligonucleotid duplex found odag mer stabil type oligonucleotid duplex thermal biolog typic without structur chang effect notabl longer odag | D009841;D012330 | T123;T114 |
36,222,325 | bioinspir total synthesi boneratamid c disclos first synthesi marin natur product boneratamid whose structur compos terpen unit link via amid bond pyroglutam acid moieti key step rout bioinspir ugi reaction axisonitril aceton carbonyl compon l glutam acid reaction bring remark effici one pot assembl reaction compon concomit lactam ring format produc boneratamid yield boneratamid b boneratamid c methyl ester also synthes use similar bioinspir strategi relat stereochemistri stereogen center substanc elucid use x ray analysi | D001688 | T121;T123 |
36,222,314 | bioplast degrad polyhydroxybutyr depolymeras thermophil soil bacterium epidem singl use plastic worsen becom critic identifi fulli renew plastic degrad use enzym describ structur biochemistri alkalin poli r hydroxybutyr acid phb depolymeras soil thermophil lihuaxuella thermophila like phb depolymeras phbase lihuaxuella enzym activ sever differ polyhydroxyalkano includ homo heteropolym l thermophila phb depolymeras ltphbase uniqu also hydrolyz polylact acid polycaprolacton ltphbase exhibit optim activ c retain activ upon incub c day resolut crystal structur reveal hydrolas fold typic phbase shallow activ site contain catalyt ser asp triad appear pois broad substrat specif ltphbase hold promis depolymer phb relat bioplast high temperatur would requir bioindustri oper like recycl landfil manag | D012987;D006885 | T167;T123;T109 |
36,222,313 | novel meso benzothiazol substitut bodipi base aie fluoresc rotor imag lysosom viscos monitor autophagi meso substitut boron dipyrromethen bodipi provid potenti innov strategi synergist construct aggreg induc emiss aie probe fluoresc rotor monitor cellular viscos chang play critic role understand function viscos close associ diseas therefor first time bodipi base fluoresc probe rotat meso benzothiazol group ration design synthes show good viscos respons aie properti probe direct linkag thiazol group show near emiss low viscous solvent howev strong emiss nm appear increas gradual increas viscos attribut effici restrict rotat meso benzothiazol group intens log display good linear relationship viscos log viscous rang cp methanolglycerol mixtur interest show enhanc emiss nm water compar pure acetonitril due aggreg induc inhibit rotat cellular imag suggest could success sens lysosom viscos chang induc lipopolysaccharid nystatin low temperatur dexamethason live cell could appli autophagi monitor trace viscos chang comparison analogu direct link phenyl group show viscos respons aie properti therefor first time report meso benzothiazol bodipi base fluoresc rotor aie lysosom viscos respons properti nervous cell appli monitor autophagi work thus could provid innov strategi design potenti aie viscos respons probe | D005456;D001895 | T196;T130 |
36,222,307 | effect exosom tumor immunomodul potenti clinic applic review exosom small extracellular vesicl contain protein nucleic acid lipid transmit inform cell interfer epigenet characterist function recipi cell tumorderiv exosom play crucial role communic tumor microenviron involv occurr develop various tumor present review articl summar biogenesi exosom communic local remot cell focus function tumorderiv exosom tumor microenviron includ promot angiogenesi induct epitheli mesenchym transform activ inhibit immun cell well effect exosom tumor microenviron microbi infect addit effect exosom tumor immunotherapi potenti applic exosom biomark deliveri vehicl cancer vaccin cancer diagnost therapeut discuss | D019496;D055354;D009369;D009696 | T116;T026;T121;T191;T123;T114;T129 |
36,222,304 | physiolog patholog role hic sever organ review integrin allow cell adher extracellular matrix promot recruit integrin result format focal adhes site bind site focal adhes site play essenti role assembl cytoskeleton vital shape structur cell also play regulatori role influenc numer biolog function cell prolifer apoptosi hydrogen peroxideinduc clone hic member paxillin famili protein adhes plaqu scaffold protein express detect vascular smooth muscl cell thus play essenti role vascular remodel well fibrot diseas hic function coactiv steroid receptor thus play role steroid hormonedepend diseas also play vital role invas metastasi various type cancer moreov sever studi demonstr hic play critic role transcript regul well numer signal pathway therefor inhibit function hic may prevent develop halt progress sever diseas use therapeut target futur investig may thus aid treatment sever diseas includ various type cancer present review articl focus express function hic differ organ aim highlight novel possibl futur research | D006861;D016023 | T116;T192;T121;T130;T197;T129 |
36,222,303 | uncov promiscu activ il protein multi dimension analysi phylogeni classif residu conserv il famili cytokin known pleiotrop behavior share bind gp receptor signal transduct necess bind receptor leukemia inhibitori factor receptor trigger il famili protein leukemia inhibitori factor lif oncostatin osm cardiotrophin ct ciliari neurotroph factor cntf cardiotrophin like cytokin factor clcf besid conserv bind site receptor much known term divers characterist protein differ organ herein describ sequenc analysi lif osm ct sever organ lif ortholog found fish regard phylogenet intrins properti impact conserv residu structur featur sequenc identifi seven class vertebr show high conserv valu bind site iii protein depend result bind site ii gravi isoelectr point molecular weight paramet relev differenti class protein enabl first time high fidel predict organ class protein type use machin learn approach osm sequenc primat show increas bc loop compar remain mammal could influenc bind osm receptor tune signal pathway overal studi highlight potenti sequenc divers analysi understand il cytokin famili evolut show conserv function relat motif evolut class protein depend characterist result could impact futur medic treatment disord associ imbal cytokin | D015850;D018121 | T192;T116;T129 |
36,222,302 | ligand induc shift conform ensembl describ transcript activ nuclear receptor function ligand regul transcript factor whose abil regul divers physiolog process close link conform chang induc upon ligand bind understand conform popul nuclear receptor shift various ligand could illumin strategi design synthet modul regul specif transcript program investig ligand induc conform chang use reconstruct ancestr nuclear receptor make substitut key posit engin receptor variant alter ligand specif combin cellular biophys experi character transcript activ well elucid mechan under alter transcript receptor variant use atomist molecular dynam md simul enhanc sampl generat ensembl wildtyp engin receptor combin multipl ligand follow conform analysi correl md base predict function ligand profil determin conform ensembl accur describ ligand respons base observ popul shift studi provid platform allow structur character physiolog relev conform ensembl well provid abil design predict transcript respons novel ligand | D056004;D018160 | T044;T066;T116;T192 |
36,222,301 | learn redefin academ success senior postdoc mani profession twist turn research forti reconsid mean make scienc | D000076363 | T080 |
36,222,299 | novel ferroptosisrel gene signatur overal surviv predict immun infiltr patient breast cancer breast cancer preval type cancer among women worldwid heterogen natur breast cancer pose serious challeng prognost predict individu therapi recent ferroptosi irondepend form program cell death report serv signific role regul biolog behavior tumor sever studi reveal prognost signific ferroptosisrel gene frg model howev addit effort requir elucid detail moreov gene modul ferroptosi may promis candid bioindic cancer therapi present studi systemat assess express profil frgs reveal relationship frgs prognost featur patient breast cancer base data obtain gene express omnibus molecular taxonomi breast cancer intern consortium use nonneg matrix factor cluster method patient breast cancer classifi two subgroup cluster cluster base express frgs furthermor cox regress least absolut shrinkag select oper method use construct risk score formula compris nine gene stratifi patient breast cancer two risk group patient belong highrisk group exhibit signific shorter overal surviv os time compar patient lowrisk group prognost valu signatur verifi train valid cohort result univari multivari cox regress analys indic risk score act independ predictor os subsequ nomogram construct receiv oper characterist analysi confirm result nomogram exhibit power discriminatori abil function analysi reveal immun environ differ notabl two group indic associ ferroptosi breast cancer prolifer migrat drug resist taken togeth present studi demonstr frgs signific associ breast cancer progress thus could use novel biomark prognost predict individu treatment patient breast cancer | D001943;D000079403 | T191;T043 |
36,222,298 | glutathion peroxidas overexpress promot malign progress cisplatin resist krasmut lung cancer cell kirsten rat sarcoma viral oncogen homolog kras aberr frequent occur patient lung cancer oncogen kras character excess reactiv oxygen speci ros accumul thus ros detoxif may contribut krasdriven lung tumorigenesi present studi influenc glutathion peroxidas gpx malign progress cisplatin resist krasdriven lung cancer explor rna sequenc data tcga lung cancer sampl geo databas download analyz effect gpx krasdriven lung tumorigenesi evalu western blot cell viabil assay soft agar assay transwel assay tumor xenograft model flow cytometri brdu incorpor assay transcriptom rna sequenc luciferas report assay rna immunoprecipit present studi gpx upregul patient nonsmal cell lung carcinoma nsclc posit correl poor overal surviv ectop gpx express facilit malign progress kras gc transform beasb cell moreov gpx overexpress promot growth migrat invas tumor xenograft growth cisplatin resist krasmut nsclc cell gpx knockdown exhibit opposit effect gpx overexpress reduc ros accumul increas matrix metalloproteinas mmp express krasmut nsclc cell addit gpx direct target mirp mmp knockdown mirp overexpress partial abrog effect gpx nsclc cell conclus result indic gpx facilit malign progress cisplatin resist krasdriven lung cancer inhibit gpx may feasibl strategi lung cancer treatment particular patient activ kras mutat | D002289;D008175;D035683 | T191;T123;T114 |
36,222,296 | role interact autophagi apoptosi tumorigenesi review autophagi high conserv process maintain cellular homeostasi evolut autophagi occur form macroautophagi microautophagi molecular chaperon autophagi among macroautophagi common apoptosi exist kind cell organ kind program cell death regul proapoptot factor antiapoptot signal main biolog featur apoptosi activ caspas apoptosi induc varieti cell signal endoplasm reticulum stress induct toxic substanc stimul pathogen microorgan dna damag inextric link found autophagi apoptosi studi found numer autophagi molecul autophagi signal pathway involv process autophagi relat apoptosi addit regul autophagi autophagi signal pathway also regul apoptosi interact two achiev dynam balanc certain extent maintain basic physiolog function cell reduc damag bodi stress diseas occur balanc autophagi apoptosi disrupt tumor form due abil cell avoid apoptosi autophagi close relat apoptosi must close connect three present review mechan autophagi apoptosi impact interact tumorigenesi shall discuss | D017209;D001343 | T043;T123;T116 |
36,222,295 | bisdemethoxycurcumin suppress human osteosarcoma u os cell migrat invas via affect pikaktnfb pikaktgsk mapk signal pathway vitro metastasi human osteosarcoma os show difficulttotreat clinic scenario result decreas qualiti life diminish surviv rate find develop novel treatment improv life qualiti patient urgent bisdemethoxycurcumin bdmc natur product obtain rhizom turmer curcuma longa exert antitumor activ numer human cancer cell line present studi show bdmc effect os cell migrat invas present studi effect bdmc cell migrat invas os u os cell investig vitro cell viabil prolifer measur flow cytometr mtt assay respect cell motil mmp activ cell migrat invas assay scratch wound heal gelatin zymographi transwel chamber assay respect protein express level measur western blot bdmc signific reduc total cell viabil bdmc signific inhibit cell motil u os cell bdmc signific suppress activ mmp mmp u os cell bdmc suppress cell invas migrat h treatment u os cell effect dosedepend manner result western blot indic bdmc signific decreas protein express level pikaktnfb pikaktgsk mapk pathway u os cell furthermor bdmc inhibit upa mmp mmp mmp ncadherin vecadherin vimentin increas ecadherin u os cell base observ suggest bdmc may potenti candid migrat invas human os cell futur | D001688;D001859;D012516 | T121;T123;T191 |
36,222,290 | ultrasound activat phase shift nanoparticl target antibacteri agent effici erad pseudomona aeruginosa biofilm biofilm physic barrier compos extracellular polymer substanc ep enabl plankton bacteria resist host respons antibacteri treatment complic effort clear bacteria pseudomona aeruginosa p aeruginosa therebi contribut persist chronic infect critic develop robust antimicrobi strategi capabl effect erad p aeruginosa biofilm address aggress clinic infect studi ultrasound activat target nanoparticl design use poli lactic co glycol acid plga nanoparticl encapsul phase transform perfluoropentan pfp antibiot meropenem via doubl emuls approach follow conjug anti p aeruginosa antibodi strategi ultrasound exposur trigger pfp produc microbubbl induc ultrason cavit effect disrupt ep compon allow nanoparticl releas meropenem kill p aeruginosa direct acceler associ wound heal nanoparticl erad biofilm effect clear bacteria vitro well exhibit potent anti infect activ vivo summari studi demonstr efficaci sonobactericid strategi mean effect reliabl elimin biofilm | D011550;D053758 | T007;T073 |
36,222,286 | overexpress rab associ tumor aggress immun infiltr glioma rab rab member ras oncogen famili aberr express various cancer exhibit oncogen properti howev function glioma remain larg unclear present studi collect rna seq data cancer genom atlas tcga dataset rna seq data chines glioma genom atlas cgga dataset bioinformat pcr analysi show rab express posit relat glioma tumor grade predict poor outcom glioma patient addit rab express signific regul classic mesenchym subtyp isol diastol hypertens wild type glioma moreov rab express remark correl inflammatori activ immun infiltr immun checkpoint glioma vitro experi demonstr inhibit rab restrain growth migrat well invas glioma cell revers epitheli mesenchym transit emt process find establish rab novel progress relat biomark possibl immunotherapi target glioma | D001932;D005910 | T191 |
36,222,278 | model conform flexibl spectral address molecular multi qubit model system dipolar coupl multi spin system potenti use molecular qubit herein report synthesi molecular multi qubit model system three individu address weak interact spin centr differ g valu use puls electron paramagnet reson epr techniqu characteris separ address individu electron spin qubit cu ii cr ni ring nitroxid determin strength inter qubit dipolar interact orient select relax induc dipolar modul enhanc os ridm detect across cu ii spectrum reveal strong correl cu ii cr ni ring relationship detect nitroxid reson measur nitroxid cu ii nitroxid cr ni ring correl switchabl interact base differ relax dynam indic handl implement epr base quantum inform process qip algorithm | D004583 | T196;T081 |
36,222,275 | redesign rifamycin antibiot overcom adp ribosyl mediat resist rifamycin antibiot valuabl class antimicrobi treat infect mycobacteria persist bacteria owe potent bactericid activ replic non replic pathogen howev clinic util rifamycin mycobacterium abscessus serious compromis novel resist mechan name rifamycin inactiv adp ribosyl use structur base approach ration redesign rifamycin strateg modif ansa chain block adp ribosyl preserv target activ valid combin biochem structur microbiolog studi potent analog overcom adp ribosyl restor intrins low nanomolar activ demonstr signific vivo antibacteri efficaci optim tune drug disposit properti afford preclin candid remark potenc outstand pharmacokinet profil | D012294;D009161 | T007;T109;T195 |
36,222,272 | diagnost valu tracheal wash cytolog monitor exercis induc pulmonari hemorrhag thoroughbr racehors lower airway cytolog propos complementari diagnost method confirm presenc quantifi sever exercis induc pulmonari hemorrhag eiph bronchoalveolar lavag usual prefer tracheal wash tw yet need sedat impos limit activ sport hors addit high invas techniqu studi aim evalu diagnost valu tw total hemosiderin score ths monitor eiph activ thoroughbr racehors sampl random select thoroughbr endoscop examin eiph grade minut compet offici race classifi group eiph negat group eiph posit group furosemid user tracheal wash fluid twfs collect hour later smear stain differenti cell count hemosiderophag grade count calcul ths differenti cell count compar median test comparison mean ths valu eiph grade group compar mann whitney test anova respect test perform criteria determin conting tabl possibl establish ths cut point statist result show ths stand view group similar result despit eiph grade anim show sign neutrophil inflamm haemosiderophag found even first time runner group thus tw detect evid lung bleed even hors histori eiph implement tw analysi diagnos eiph racehors promis tw low cost less invas tool | D006734;D010805;D008171;D006470 | T038;T047;T046 |
36,222,268 | structur revis balsamisid establish empir rule distinguish four class biflavonoid balsamisid anti inflammatori neurotroph biflavonoid glycosid origin propos possess epoxid function c c posit howev inconsist c nmr chemic shift valu previous report analog indic reanalysi nmr data structur necessari comput method aid dp probabl techniqu ecd calcul enabl structur reassign dihydro hydroxyfuran dhf instead epoxid addit two new biflavonoid glycosid balsamisid e f possess dihydro hydroxyfuran dhf dioxan ring respect character convent nmr ms data analysi well dp ecd method systemat c nmr analysi perform four aforement class biflavonoid dhf epoxid dioxan result diagnost c nmr chemic shift valu c c rapid determin four biflavonoid class formul base first empir rule bi flavonoid eight previous report one structur revis | D044946 | T121;T109 |
36,222,263 | cell growth cell cycl new insight persist question cell divid two daughter cell typic doubl dna also mass numer studi cell rang yeast mammal shown cellular growth stimul nutrient andor growth factor signal prerequisit cell cycl progress type cell textbook view growth regul cell cycl growth signal activ transcript g cyclin gene induc cell prolifer also stimul anabol metabol cell growth parallel howev genet knockout test model organ indic whole stori new studi show addit smarter mechan help coordin cell cycl growth summar recent advanc field discuss current model growth signal regul cell prolifer target core cell cycl regul via non transcript mechan | D002453;D018797;D049109 | T043;T123;T116 |
36,222,262 | hypoglycem activ vitro vivo water solubl polysaccharid astragalus membranaceus polysaccharid amp one main bioactiv compon astragalus membranaceus fisch bung separ character result show amp typic acid heteropolysaccharid domin glucos galacturon acid arabinos typic shear thin fluid like behavior scan electron microscopi imag show amp exist state lamellar aggreg smooth compact surfac addit amp exhibit strong antioxid activ oxygen radic absorpt capac valu te per g excel glucosidas inhibitori activ cholat bind abil furthermor vivo amp treatment signific decreas blood glucos serum insulin level improv glucos intoler insulin resist regul blood lipid profil allevi oxid stress reliev liver damag type diabet mellitus tdm mice pearson correl analysi suggest mitig oxid stress contribut hypoglycem effect amp indic benefici function food ingredi tdm | D027885;D003924 | T047;T002 |
36,222,258 | screen riski substanc sea cucumb base gas chromatographi orbitrap high resolut mass spectrometri new method sampl pretreat use improv quecher establish organ pollut health risk could identifi quantifi gas chromatographi orbitrap high resolut mass spectrometri gc orbitrap hrms high resolut databas environment pollut belong ten categori includ organochlorin pesticid ocp polycycl aromat hydrocarbon pah phthalat pae polychlorin biphenyl pcbs agricultur chemic ac establish non target screen quantit analysi simpl method biolog sampl prepar use improv quecher propos combin convent quecher method column purif method purif use florisil column lipid content reduc signific reduc interfer matrix effect observ analysi furthermor simultan high accuraci qualit screen quantit analysi target compound perform high resolut mass spectrometri resolut conduct full scan mode limit quantif pgg present larg linear rang recoveri rang due high resolut sensit q exact gc orbitrap hrms limit quantif target compound signific lower achiev method base convent chromatographi mass spectrometri moreov ultratrac organ contamin detect convent method accur quantifi propos method sea cucumb sampl collect breed site analyz use propos high coverag multi object analyt method type organ pollut detect mean content pah ac pae ocp ngg dw respect higher pollut new contamin chlorofluoren chloroacenaphthen methylcholanthren detect low content first time sea cucumb sampl propos method simpl effici allow detect pollut low content provid accur reliabl result thus high coverag multi object analyt method wide use broad spectrum screen accur quantif contamin various aquat product provid technic support food safeti control | D004785;D006843;D010575;D011078;D011084;D012616 | T109;T131;T204 |
36,222,257 | determin polychlorin naphthalen soil use acceler solvent extract molecular siev solid phase extract coupl gas chromatographi tandem mass spectrometri emerg pollut ep chemic substanc common regul detect low low concentr howev ep trigger special concern long term advers effect environ human health remain unknown ep show biolog toxic environment persist bioaccumul even low concentr environ ep may pose signific environment health risk therefor treatment explicit includ th five year plan nation econom social develop peopl republ china outlin long term goal soil sourc pollut qualiti direct relat econom develop ecolog secur peopl livelihood present china soil environment monitor system perfect abil monitor new organ pollut lag therefor strengthen supervis construct agricultur land soil environ essenti strengthen soil environ monitor abil ep establish reliabl steadi econom analysi method includ separ analysi method soil polychlorin naphthalen pcns receiv consider attent emerg halogen compound list annex c stockholm convent persist organ pollut pop persist multimedia fate toxic pcns detect surround soil owe trace level complex soil high requir put forward pretreat instrument analysi pcns studi aim develop new method select purif pcns soil effect remov lipid interfer soil also effect reduc time labor materi cost pre treatment process base physicochem properti x molecular siev explor purifi soil extract solid phase extract spe sorbent n hexan load rins solvent ml dichloromethanen hexan mixtur vv use elut pcns moreov select separ target substanc lipid macromolecul interfer could achiev simultan select separ pcns averag recoveri intern standard could reach x molecular siev superior gel permeat chromatographi gpc florisil spe exhibit good cleanup effici similar multilay silica gelalumina column although obtain recoveri high obtain multilay silica gelalumina column x molecular siev advantag term simpl oper environment friendli low cost base fundament experi acceler solvent extract use extract target soil molecular siev use spe sorbent purif gc msms employ pcn analysi method develop systemat analyt method pcns determin method detect limit mdls pcn homolog rang ngg precis accuraci method evalu use spike matric three spike level ng recoveri pcns cn respect correspond relat standard deriv thus method meet requir trace analysi show accept parallel sensit accuraci precis thus feasibl analysi emerg pollut method expect play import role sampl pretreat futur especi nationwid investig soil pollut | D004785;D012987 | T167;T131 |
36,222,256 | polyamidoamin dendrim function silica nanocomposit polydopamin coat dispers micro solid phase extract benzoylurea insecticid water sampl pesticid use agricultur product process ensur yield qualiti agricultur product howev recent year environment pollut issu caus pesticid residu spark widespread concern societi import develop conveni effici approach detect monitor pesticid residu studi target benzoylurea insecticid bus polyamidoamin dendrim function silica nanocomposit polydopamin coat sio pamam pda design success synthes first monodispers silica nanoparticl prepar hydrolysi tetraethyl orthosil teo mix solut ethanol water ammonia silan coupl agent aminopropyl triethoxysilan employ introduc amino group silica silica zeroth generat polyamidoamin pamam modif sio pamam g obtain michael addit reaction methyl acryl ethylenediamin ad polymer methyl acryl use amid reaction form first generat pamam sio pamam g final polymer dopamin alkalin condit ph sio pamam g coat pda thus final product name sio pamam pda obtain composit character use transmiss electron microscop tem increas surfac rough indic success graft pda coat dopamin structur contain abund benzen ring amino hydroxyl group could bind bus multipl secondari interact hydrogen bond stack interact therefor introduct pda could effect enhanc affin materi toward benzoylurea insecticid prepar nanocomposit use sorbent dispers micro solid phase extract approach spe establish approach employ extract enrich bus water sampl high perform liquid chromatographi hplc analysi diflubenzuron triflumuron hexaflumuron teflubenzuron chosen target analyt follow typic spe procedur prepar adsorb measur mg first dispers ml sampl solut contain gl nacl dispers assist vortex ensur full contact sio pamam pda target next adsorb separ liquid phase min centrifug rmin thereaft adsorb benzoylurea elut use ml acetonitril desorpt solvent vortex separ centrifug eluat dri mild nitrogen stream solid remain redissolv ml acetonitril filter filter membran analyz hplc experiment condit spe process could great impact extract effici experiment condit optim use singl factor optim approach enhanc extract recoveri optim condit includ adsorb amount extract time desorpt solvent type desorpt solvent volum desorpt time nacl addit amount optim condit linear rang gl limit detect lod sn gl obtain extract recoveri relat standard deviat rsds four bus respect establish approach compar report approach target benzoylurea insecticid discov approach consum less sampl materi organ solvent pretreat time provid rapid green choic determin benzoylurea pesticid determin applic propos approach appli analyz four benzoylurea insecticid three river water sampl real water sampl pretreat use develop approach ahead instrument analysi benzoylurea pesticid residu detect next standard addit experi perform three spike level includ gl establish approach good accuraci feasibl satisfactori recoveri rsds | D050091;D004132;D007306;D053761;D010573 | T073;T131;T122;T121;T109;T104 |
36,222,255 | prepar sulfon acid function polymer ionic liquid base magnet adsorb applic diquat extract term structur polar pollut design develop new materi interact target analyt vital effect extract diquat broad spectrum herbicid strong toxic spray grow process veget high effici low cost furthermor diquat polar basic cation organ compound therefor necessari develop adsorb form strong interact diquat extract complex veget sampl studi sulfon acid function ionic liquid vinyl propyl sulfon imidazolium chlorid vpimi h cl synthes reaction vinylimidazol propanesulton character use nuclear magnet reson spectroscopi result vpimi h cl immobil surfac vinyl modifi magnet silica obtain poli vinyl propyl sulfon imidazolium chlorid modifi magnet nanoparticl poli vpimi h cl mp via free radic polymer vinyl group structur morpholog magnet obtain poli vpimi h cl mp character use fourier transform infrar spectroscopi scan electron microscop vibrat sampl magnetomet thermogravimetr analysi character result indic poli vpimi h cl mp synthes strong magnet properti poli vpimi h cl mp magnet adsorb exhibit differ ph respons anion cation increas solut ph adsorpt effici poli vpimi h cl mp anion dye amaranth decreas wherea adsorpt effici cation dye methylen blue increas high ph condit sulfon acid group surfac poli vpimi h cl mp exist form thus adsorpt effici poli vpimi h cl mp methylen blue could reach due strong electrostat attract adsorb posit charg methylen blue wherea negat charg amaranth could hard adsorb due electrostat repuls adsorb amaranth result show sulfon acid modif endow poli vpimi h cl mp abund negat charg certain ph condit thus extract achiev strong electrostat attract negat charg poli vpimi h cl mp posit charg diquat use green veget sampl matrix magnet solid phase extract extract model extract perform poli vpimi h cl mp diquat studi extract paramet affect extract effici solut ph adsorb amount adsorpt time desorpt solvent volum desorpt time optim use singl factor experi method optim extract condit mg adsorb min adsorpt time l ammonia l acetonitril formic acid vv desorpt solvent min desorpt time perform applic propos method investig combin magnet solid phase extract high perform liquid chromatographi uv visibl detector good linear observ content rang gg correl coeffici r limit detect limit quantif base signal nois ratio gg respect spike recoveri three level gg obtain rang relat standard deviat n result show sulfon acid function poli vpimi h cl mp could employ magnet adsorb quick effect extract diquat propos method could use determin diquat green veget sampl could anticip poli vpimi h cl mp could use adsorb extract cation polar pollut adjust solut ph work provid new way construct adsorb extract polar pollut | D004785;D006540;D052578 | T103;T131;T120 |
36,222,254 | effici enrich pesticid environment water sampl cobalt nickel doubl metal hydroxid nanocagemultiwal carbon nanotub composit pesticid wide use agricultur increas grain yield prevent crop diseas insect pest howev pesticid pose serious threat ecosystem human health owe high toxic persist therefor imper establish effici sensit detect method pesticid water sampl rapid accur detect trace pesticid environment water sampl challeng complex matrix effect trace concentr appropri sampl pretreat critic step effect extract analyt remov interfer develop design novel stabl nanomateri adsorb key continu innov sampl pretreat technolog recent year carboxyl multiwal carbon nanotub mwcnts cooh layer doubl hydroxid ldhs wide use new adsorb materi various pretreat technolog larg specif surfac area good stabil easi function base background mwcnts cooh ldhs combin obtain new effici composit adsorb synergist effect individu compon could exploit entireti studi zeolit metal organ framework zif multiwal carbon nanotub zif mwcnts composit prepar simpl one step method cobalt nickel doubl metal hydroxidemultiwal carbon nanotub coni ldhmwcnts hybrid materi three dimension cage like structur synthes solvotherm method use zif mwcnts templat cage like structur coni ldhmwcnts composit differ tradit layer bimetal hydroxid could acceler mass transfer given excel properti coni ldhmwcnts composit use solid phase microextract spme coat effici enrich six pesticid chlorothalonil tebuconazol chlorpyrifo butralin deltamethrin pyridaben combin high perform liquid chromatographi ultraviolet hplc uv detect determin six pesticid real water sampl prepar materi character scan electron microscopi electron dispers spectroscopi infrar spectroscopi x ray powder diffract n adsorptiondesorpt result confirm coni ldhmwcnts composit success synthes surfac area pore volum g cm g respect orthogon array design use optim extract condit spme includ extract time extract temperatur stir rate salt effect desorpt time optim extract condit follow extract temperatur extract time min stir rate rmin desorpt time min salt nacl mass concentr mgl optim condit method wide linear rang chlorothalonil gl tebuconazol gl chlorpyrifo gl butralin gl deltamethrin gl pyridaben gl low detect limit gl good reproduc relat standard deviat rsds singl fiber fiber fiber rang respect spike recoveri two level gl gl rang rsds less compar coat fiber mwcnts cooh zif zif mwcnts silicon sealant coni ldhmwcnts coat fiber show better enrich effect pesticid attribut high specif surfac area interact hydrophob interact cation interact hydrogen bond interact coni ldhmwcnts coat target analyt enhanc abil extract pesticid stabil test spme fiber reveal cycl extract effici coni ldhmwcnts coat fiber six pesticid decreas slight impli coat fiber good stabil reusabl therefor method use detect pesticid residu environment water sampl high select sensit accuraci | D004390;D000073396;D037742;D010573;D010575 | T104;T109;T131;T073 |
36,222,253 | one pot prepar amin carbon nanotub modifi magnet nanoparticl applic quantif phenoxyacet acid herbicid cereal veget sampl phenoxyacet acid herbicid pas wide use control growth broad leaf weed corn tobacco etc presenc pas plant even low concentr ngl gl scale may induc sever effect lead human health risk henc sensit reliabl method determin pas trace level cereal veget high desir magnet solid phase extract mspe attract consider attent account benefit eas separ less solvent consumpt good servic life studi amin carbon nanotub modifi magnet nanoparticl nh cnts prepar conveni simpl one pot strategi employ adsorb mspe pas crop fabric procedur conveni detail amin carbon nanotub fe fe isopropanol mix one pot mechan stir react h spectroscop properti morpholog magnet properti synthet adsorb character fourier transform infrar spectroscopi ft ir scan electron microscopi sem transmiss electron microscopi tem result reveal size fe diamet nh cnts magnet satur valu nh cnts nm nm emug respect addit result ft ir tem character confirm success fabric nh cnts one pot hydrotherm approach nh cnts display satisfactori capabl captur pas hydrophob hydrogen bond interact realiz best extract perform key paramet includ amount adsorb formic acid concentr eluent adsorpt desorpt time sampl ph ionic strength sampl matric inspect studi detail optim condit follow amount nh cnts mg desorpt solvent ml acetonitril contain vv formic acid adsorpt desorpt time min respect sampl ph adjust salt ad sampl optim extract condit sensit quick environment friend method determin studi pas cereal veget sampl establish combin nh cnts mmspe high perform liquid chromatographi diod array detect hplc dad enrich factor studi pas vari limit detect sn pas cereal veget matrix rang gkg gkg respect limit quantif sn pas cereal veget matrix gkg gkg develop method also show wide linear rang good precis final establish nh cnts mmspe hplc dad approach appli measur trace level pas cereal veget good fortifi recoveri repeat rsds obtain establish approach sever advantag exist method high analyt speed low lod eco friendli | D006540;D058185;D037742 | T104;T131;T073;T130 |
36,222,252 | prepar applic graphen oxid function melamin formaldehyd aerogel coat solid phase microextract tube mani solid phase microextract spme sorbent develop aerogel low densiti larg surfac area high poros melamin formaldehyd mf aerogel made melamin formaldehyd sol gel reaction one typic organ aerogel mf aerogel better mechan strength chemic stabil extract perform inorgan aerogel perform aerogel limit field composit aerogel meet differ requir good mechan strength strong adsorpt perform graphen oxid go two dimension nanomateri compos singl layer carbon atom provid interact larg electron addit oxygen contain group edg lamellar structur improv hydrophil materi interact various compound improv extract perform mf aerogel polycycl aromat hydrocarbon pah gomf aerogel prepar function mf aerogel go studi g melamin mg sodium carbon dissolv ml water mixtur heat stir ml formaldehyd solut slowli ad clear solut obtain gradual next mg go powder ultrason dispers ml water even mix solut adjust ph sol gel process perform h gel age room temperatur h gel soak ethanol aceton cyclohexan turn replac solvent final gomf aerogel obtain freez dri h gomf aerogel character scan electron microscopi sem x ray photoelectr spectroscopi xps confirm go success introduc mf aerogel retain three dimension network porous structur gomf aerogel coat onto surfac stainless steel wire use sorbent four wire place polyetheretherketon peek tube mm cm length tube spme tube combin high perform liquid chromatographi hplc unit construct spme hplc onlin system six way valv load state sampl solut achiev onlin enrich analyt flow extract tube extract valv turn inject state analyt elut chromatograph column mobil phase flow rate mlmin separ detect detector extract condit sampl volum ml sampl rate mlmin concentr polycycl aromat hydrocarbon pah viz naphthalen nap acenaphthylen aci acenaphthen ace fluorin flu phenanthren phe anthracen ant fluoranthen fla pyren pyr gl gomf aerogel base tube compar mf aerogel base tube go enhanc enrich effici mf aerogel toward pah time due increas number adsorpt site enhanc interact pah spme affect sampl volum sampl rate concentr organ solvent sampl desorpt solvent desorpt rate desorpt time obtain accur result main extract desorpt condit sampl volum sampl rate organ solvent concentr desorpt time investig care sampl volum extract tube increas extract effici found increas gradual satur studi extract effici investig sampl volum rang ml ml select suitabl sampl volum achiev satisfactori extract effici sampl rate affect extract effici also extract time sampl flow extract tube low rate requir long test time although increas sampl rate reduc extract time often decreas extract effici addit larg sampl rate lead high pressur tube turn reduc servic life tube therefor effect sampl rate mlmin extract effici investig good extract effici short test time achiev sampl rate mlmin high hydrophob pah poor solubl water appropri amount organ solvent sampl solut improv solubl pah obtain accur analyt result howev extract effici affect ad organ solvent thus effect volum fraction methanol vv extract effici investig sampl solut without methanol afford better extract effici satisfactori repeat onlin extract desorpt direct affect desorpt effici peak area eight pah investig differ desorpt time min desorpt time min requir fulli desorb analyt reduc residu spme hplc dad method establish optim condit limit detect lod linear equat linear rang correl coeffici obtain lod eight pah rang gl quantit rang analyt gl fla pyr gl phe ant gl nap aci ace flu enrich factor rang analyt precis satisfactori intra day rsd inter day rsd compar report method method report herein provid higher sensit wider linear rang shorter test time method appli detect pah common drink water includ bottl miner water water drink fountain satisfactori recoveri obtain prove method suitabl determin trace pah real water sampl high sensit rapid test onlin detect good accuraci extract tube also exhibit satisfactori durabl chemic stabil | D060766;D006108;D008900;D010616;D011084 | T167;T121;T109;T196;T197 |
36,222,251 | research progress applic deriv porous carbon materi solid phase microextract concentr target analyt sampl low complex matric lead varieti interfer therefor import pretreat sampl analysi compar time consum tedious environment unfriend solvent base sampl pretreat method pretreat techniqu base adsorpt promis applic adsorpt base pretreat technolog includ solid phase extract dispers solid phase extract magnet solid phase extract solid phase microextract among solid phase microextract integr sampl extract enrich inject singl step advantag solvent free high effici time effici labor effici extract effici solid phase microextract close relat coat materi various type coat materi includ metal organ framework coval organ framework molecular imprint polym porous carbon materi porous carbon materi includ tradit porous carbon materi activ carbon carbon nanotub carbon molecular siev deriv porous carbon materi given advantag larg specif surfac area control porous structur larg number activ site well good physic chemic stabil porous carbon materi wide use batteri supercapacitor catalysi adsorpt separ porous carbon materi also popular coat materi solid phase microextract particular deriv porous carbon materi find widespread use given varieti design materi deriv biomass metal organ framework precursor addit past studi main focus structur optim deriv porous carbon materi howev applic deriv porous carbon materi solid phase microextract restrict follow problem prepar porous carbon materi deriv coval organ framework seen great progress howev studi applic solid phase microextract prepar deriv porous carbon materi excel extract abil appli solid phase microextract coat howev less systemat clear mechan explain deriv porous carbon materi use solid phase microextract coat show nice extract perform specif analyt polar non polar substanc therefor paper research progress deriv porous carbon materi solid phase microextract past three year summar futur research prospect prospect coval organ framework use precursor prepar deriv porous carbon materi narrow pore size distribut larg specif surfac area necessari develop porous carbon materi deriv coval organ framework solid phase microextract coat specif mechan under extract effect also clarifi addit necessari develop high perform deriv porous coat materi broad spectrum high sensit analysi pollut differ physic chemic properti therefor hierarch porous carbon materi wide studi solid phase microextract multimod pore size total refer cite paper elsevi databas | D004785;D000073396;D037742 | T104;T109;T131;T073 |
36,222,250 | progress sampl pretreat detect method hexabromocyclododecan hexabromocyclododecan hbcds group bromin flame retard extens employ industri product plastic furnitur construct materi due regular use massiv emiss hbcds distribut environ air water soil sediment due high toxic persist long distanc transport bioaccumul hbcds list stockholm convent thus accur analysi strict control pollut level hbcds environment sampl critic govern long term environment supervis mechan howev concentr level hbcds real sampl low combin complex matric serious limit determin hbcds target isom particular transform degrad make analysi challeng due high temperatur specif organ solvent physicochem featur toxic environment danger usag standard limit hbcds briefli discuss herein sampl pretreat instrument detect hbcds various matric summar e soil sediment food electron atmospher anim water research paper scienc citat index sci chines core public cite herein first entir process extract purif separ enrich hbcds compar includ soxhlet extract se ultrason assist extract uae acceler solvent extract ase supercrit fluid extract sfe solid phase extract spe dispers solid phase extract dspe liquid liquid extract lle dispers liquid liquid microextract dllme solid phase microextract spme literatur uae common employ process account quarter hbcds sampl pretreat addit spe sampl pretreat technolog complet separ target impur reduc effect matrix enrich target improv sensit method use spe technolog enrich factor increas due massiv sampl volum thus enabl detect hbcds concentr nanogram per liter level water second advantag disadvantag instrument approach examin discuss includ gas chromatographi gc gas chromatographi mass spectrometri gc ms liquid chromatographi lc liquid chromatographi tandem mass spectrometri lc msms offer refer meet requir determin hbcds real sampl e total hbcds detect gc gc ms three hbcd isom hbcd hbcd hbcd determin lc lc ms use tripl quadrupol mass spectromet sensit method improv till date lc msms chosen instrument determin hbcds various matric e seawat marin sediment marin organ toy electron product china howev sever challeng sampl pretreat tedious larg sampl volum organ solvent util challeng point develop trend analyt approach hbcds develop green autom low cost fast effici sampl pretreat approach new adsorpt materi main develop direct analysi hbcds futur | D005411;D006842 | T109;T120 |
36,222,249 | applic smart respons materi phosphopeptid glycopeptid enrich phosphoryl glycosyl protein two wide studi post translat modif ptms shown increas potenti earli non invas diagnosi prognosi therapeut evalu diseas besid regul function cell membran intracellular signal transduct protein phosphoryl particip mitochondri function cellular transcript metabol protein glycosyl play import role intracellular extracellular signal transduct intracellular endocytosi aberr phosphoryl glycosyl protein frequent observ clinic proteom studi discoveri diseas relat biomark general three method detect protein phosphorylationglycosyl isotop radiolabel western blot mass spectrometri mass spectrometri becom import advantag detect method due high throughput time labor effici howev phosphopeptid glycopeptid low stoichiometri ionize effici larg number non phosphopeptid glycopeptid interfer issu make difficult direct detect phosphopeptid glycopeptid mass spectrometri therefor enrich phosphopeptid glycopeptid mass spectrometri detect key step present varieti materi develop enrich studi phosphopeptid glycopeptid exampl immobil metal affin imac metal oxid affin chromatographi moac method most use enrich phosphopeptid imac main use posit charg metal ion negat charg phosphat group attract purpos enrich phosphopeptid moac materi reli chelat metal atom phosphat oxygen captur phosphopeptid imac moac materi reli strong interact metal phosphat group often lead difficult elut enrich method glycopeptid main base differ hydrophil glycopeptid non glycopeptid main enrich hydrophil interact chromatographi hilic addit materi contain compound boron acid lectin materi also wide use separ enrich glycopeptid smart respons materi also success report enrich phosphopeptid glycopeptid due uniqu respons revers smart respons materi respond extern stimuli undergo structur properti chang convert signal optic electr thermal mechan biochem signal respons molecul prerequisit determin respons properti smart respons materi revers isomer differ stimuli temperatur ph light mechan stress electromagnet field lead dynam chang physic chemic properti materi compar tradit materi smart respons materi revers turn better control exogen stimuli includ temperatur light ultrasound electromagnet field mechan stress implement specif time space exogen respons materi depend chang reaction system non invas enzym ph redox solut polar ionic strength endogen stimuli endogen respons materi depend chang reaction system sometim regul process requir introduct chemic reaction system identif captur releas phosphopeptid glycopeptid achiev modul interact smart respons materi phosphopeptid glycopeptid hydrogen bond electrostat hydrophob interact review classifi smart respons materi accord type stimuli specif divid exogen endogen respons materi enrich phosphopeptid glycopeptid exogenousendogen respons materi endogenousexogen co respons materi summar addit discuss develop prospect smart respons materi enrich phosphopeptid glycopeptid also rais challeng exist applic smart respons materi protein post translat modif | D010748;D000080745 | T073;T116 |
36,222,247 | ser multiplex profil melanoma circul tumor cell predict respons immun checkpoint blockad therapi immun checkpoint blockad icb therapi achiev remark success mani cancer includ melanoma howev icb therapi benefit small proport patient produc sever side effect patient thus urgent need identifi patient like respond icb therapi improv outcom minim side effect predict icb therapi respons design surfac enhanc raman scatter ser assay multiplex profil circul tumor cell ctcs basal interferon ifn stimul simultan ensembl singl cell measur ctcs ser assay reveal tumor heterogen offer comprehens ctc phenotyp decis make anisotrop gold silver alloy nanobox util ser plasmon substrat improv signal readout ctc surfac biomark generat uniqu ctc signatur four surfac biomark develop assay enabl differenti ctcs three differ patient deriv melanoma cell line signific cohort melanoma patient receiv program cell death blockad therapi chang ctc signatur induc ifn stimul ctcs show potenti predict respond expect ser assay help select patient receiv icb therapi cancer | D009360;D008545 | T191;T025 |
36,222,244 | potenti toxic element iron mine tail effect reduc soil ph avail concentr toxic element tail iron mine character high concentr iron manganes oxid well high ph valu characterist potenti toxic element pte contain tail somewhat unavail aim present studi evalu reduct ph iron mine tail may affect pte avail tail collect bank gualaxo nort river mariana mg brazil one main area impact ruptur fundo dam barragem de fundo complet random experiment design use includ five ph valu five replic concentr pte ba cr cd co cu fe mn pb ni zn determin extract follow differ methodolog usepa dtpa mehlich mehlich distil water comparison avail concentr element tail soil impact tail show cr cd cu fe mn ni ba co higher soil impact tail differ method use evalu avail pte tail various ph exhibit follow decreas order relat quantiti extract mehlich mehlich dtpa distil water howev regard sensit chang ph order dtpa water mehlich mehlich increas concentr pte due reduct ph tail lead concentr exceed limit brazilian regul dtpa extract exhibit higher coeffici correl pte concentr ph tail prove suitabl use area affect deposit iron mine tail | D007501;D008906;D012989 | T131;T121;T057;T123;T196 |
36,222,243 | organocatalyt asymmetr synthesi synvest synapt densiti positron emiss tomographi imag agent heterocycl nonacetamid ligand use positron emiss tomographi pet imag agent synapt vesicl glycoprotein sva potenti applic diagnosi various neuropsychiatr diseas date main synthet strategi access optic activ compound involv racem synthesi late stage intermedi follow separ enantiom describ use iminium organocatalysi asymmetr synthesi synvest import pet imag agent sva key step involv conjug addit nitromethan cinnamaldehyd presenc jrgensen hayashi catalyst use merck dual acid cocatalyst system pinnick type oxid esterif adduct follow chemoselect nitro group reduct cyclize use nickel borat n alkyl result lactam complet seven step synthesi synvest approach amen synthesi organotin analogu follow copper ii mediat fluoro destannyl allow rapid access f synvest | D008562;D049268 | T060;T123;T116 |
36,222,238 | autism associ chd keep prolifer human neural progenitor check lengthen g phase cell cycl de novo mutat dnms chromodomain helicas dna bind protein chd associ specif subtyp autism character enlarg head distinct cranial featur vast major dnms heterozyg loss function mutat high penetr autism chd chromatin remodel preferenti regul express gene implic earli develop cerebr cortex chd haploinsuffici alter normal development trajectori brain poor understood debat use long term singl cell imag show disrupt singl copi chd human neural precursor cell npcs mark shorten g phase cell cycl consist faster progress chd npcs g gs checkpoint observ increas express e cyclin elev phosphoryl erk mutant cell two central signal pathway involv phase entri thus chd keep prolifer npcs check lengthen g mono allel disrupt gene alter cell cycl time way favor self renew neurogen cell divis find predict enlarg neural progenitor pool chd develop brain provid mechanist basi macrocephali autism subtyp | D000067877;D001321;D058953 | T025;T048 |
36,222,234 | direct fluoresc evalu amino acid oxidas activ use synthet kynurenin deriv amino acid oxidas dao suggest associ central nervous system diseas schizophrenia newli synthes nonfluoresc methylthio kynurenin mes kyn convert blue fluoresc mes kynuren acid mes kyna ex nm em nm one step reaction incub dao reveal fluoresc intens increas accompani commerci porcin kidney dao activ unit good correl r suggest fluorometr evalu dao activ use mes kyn feasibl mes kyn appli fluoresc dao imag cultur llc pk cell blue fluoresc mes kyna overlap consider locat peroxisom suggest locat dao cell fluoresc diminish presenc chloro benzisoxazol h one cbio dao inhibitor consid dao activ cell could direct evalu use mes kyn substrat | D007737;D012559 | T123;T116;T048 |
36,222,232 | transderm deliveri via medic devic technolog despit effect indispens mani drug poor solvat aqueous solut recent decad need target drug deliveri led develop pharmaceut formul enhanc lipid solubl improv deliveri properti therefor depend approach administ lipid solubl drug need develop | D013678;D016503 | T074;T091 |
36,222,228 | cluster domin electrochemiluminesc tertiari amin polyethyleneimin nanoparticl mechan insight sens applic design screen high effici cost effect luminophor alway challeng develop sensit electrochemiluminesc ecl biosensor herein polyethyleneimin nanoparticl pei nps kind nonconjug polym ncp nps tertiari amin cluster develop ecl luminophor specif pei nps synthes one step hydrotherm method use pei formaldehyd properti pei nps investig detail use photochem electrochem techniqu result show cluster domin luminesc tertiari amin pei nps via space conjug non neglig ecl perform nm also verifi initi reduct oxid process persulf coreact pei nps act luminophor coreact acceler enhanc ecl intens remark eightfold higher isol pei moreov choos dopamin model target high sensit signal ternari ecl sensor construct util pei nps luminophor dopamin could oxid benzoquinon sens interfac quench signal via ecl energi transfer free signal amplif propos sensor achiev low detect limit nm target monitor good select stabil strategi provid uniqu perspect design novel effici facil ecl luminophor tertiari amin also broaden biolog applic ncp nps | D011094;D053758 | T109;T073;T130 |
36,222,227 | circ inhibit unsatur fatti acid synthesi interact mir p enhanc ppar express dairi goat mammari gland understand precis mechan control metabol fatti acid mammari gland dairi goat essenti futur improv milk qualiti particular sinc recent data underscor key role circular rnas circrna mammari gland function high throughput sequenc technolog use identifi express level circrna mammari tissu dairi goat earli peak lactat present studi compar earli lactat result demonstr express level circ peak lactat fold regul subsequ studi goat mammari epitheli cell gmec reveal circ stimul synthesi triglycerid tag cholesterol well increas content satur fatti acid c c import use doubl luciferas report system allow us detect circ sequenc bind site mir p indic target mirna overexpress circ signific decreas abund mir p led inhibit tag synthesi contrast abund peroxisom prolifer activ receptor ppar target gene mir p reinforc overexpress circ thus conclud one key function circ regul milk fat synthesi attenu inhibitori effect mir p ppar via direct interact mirna result process tag satur fatti acid abl proceed | D047495;D035683 | T123;T116;T114;T192 |
36,222,222 | heparin induc persist hyperthermia recurr hyponatremia hip fractur case report review literatur heparin common use anticoagul clinic persist hyperthermia recurr hyponatremia caus heparin extrem rare drug fever difficult judg earli stage often misdiagnos | D007010;D006979 | T061;T047 |
36,222,212 | sebac gland atrophi seborrh dermat scalp pilot studi sebac gland sg atrophi well document scalp lesion psoriasi consid import clue psoriat alopecia howev specif psoriasi question year hypothes sg atrophi specif psoriasi look presenc biopsi seborrh dermat scalp | D012628;D011565 | T047 |
36,222,210 | cutan metastas non cutan neuroendocrin neoplasm histopatholog review case cutan metastas non cutan neuroendocrin neoplasm rare howev distinct primari neuroendocrin carcinoma skin merkel cell carcinoma guid clinic manag | D015266;D018278;D018288;D008175;D012878 | T191 |
36,222,201 | kinmod databas tool investig metabol regul abil current kinet model simul phenotyp behaviour cell limit sinc cell metabol regul differ level includ enzym regul small molecul regul network smrn enabl cell respond rapid environment fluctuat control activ enzym metabol pathway howev smrn well studi relat metabol network main contributor lack knowledg regulatori system sparsiti experiment data absenc standard framework repres avail inform paper introduc kinmod databas encompass million data point metabol metabol regul network organ kinmod databas employ hierarch data structur signifi relationship kinet inform obtain vitro experi protein emphasi smrn ii provid thorough insight avail kinet paramet miss experiment measur regulatori network iii facilit machin learn approach paramet estim accur kinet model construct provid homogen list link omic data hierarch ontolog kinmod databas allow flexibl explor data attribut investig metabol relationship within cross speci identifi miss experiment valu suggest addit experi requir kinet paramet estim link multi omic data provid data smrn encourag develop novel machin learn techniqu predict miss kinet paramet promot accur kinet model construct cell metabol provid comprehens list avail kinet measur illustr valu kinmod data develop six analys visual associ data class belong separ section metabol analys demonstr kinmod databas provid uniqu framework biologist engin retriev evalu compar function metabol speci includ regulatori network discov extent avail miss experiment valu metabol regul databas url https lmseutorontocakinmodkinmodsqlgz | D001669;D008954 | T075;T044;T070 |
36,222,190 | oliv leaf extract inhibit metastat melanoma spread suppress epitheli mesenchym transit oliv tree leav abund sourc bioactiv compound sever benefici effect human health includ protect role mani type cancer studi investig effect extract obtain oliv tree olea europaea l leav ole prolifer invas epitheli mesenchym transit emt metastat melanoma high aggress form skin cancer deadliest diseas result demonstr ole inhibit melanoma cell prolifer cell cycl arrest induct apoptot cell death moreov ole suppress migrat invas coloni format human melanoma cell similar vitro find demonstr oral administr ole inhibit cutan tumor growth lung metastasi format vivo modul express emt relat factor addit anti prolif anti invas effect ole melanoma also relat simultan target mitogen activ protein kinas pik pathway vitro vivo conclus find suggest ole potenti inhibit metastat spread melanoma cell thank multifacet mechanist effect may repres new add therapi manag metastat melanoma | D008545;D031658 | T191;T168;T002 |
36,222,186 | gbp serv novel prognost biomark potenti immun microenviron indic renal cell carcinoma sinc applic immun checkpoint therapi ict gradual becom new strategi clear cell renal cell carcinoma ccrcc treatment biomark predict individu respons ict need studi aim identifi new clinic indic postop surveil ccrcc predict ict respons investig gbp express relat immun cell infiltr tumor microenviron use public databas clinic specimen ccrcc cell line bioinformat analysi use public databas reveal gbp express higher cancer tissu adher normal tissu among differ cancer type includ ccrcc result acquir clinic tissu sampl test western blot pcr ccrcc cell line cck prolifer assay apoptosi assess suggest gbp facilit malign ccrcc ccrcc patient random divid train valid cohort immunohistochemistri ihc kaplan meier analysi reveal higher gbp express relat wors prognosi c index analysi impli integr gbp express tnm stage improv accuraci predict prognosi ccrcc patient compar solitari use either bioinformat analysi impli relat gbp immun gbp express posit relat suppress immun marker ccrcc microenviron taken togeth studi demonstr potenti gbp sever prognost predictor ccrcc associ gbp tumor infiltr lymphocyt ccrcc observ make promis indic ict respons | D002292;D007680 | T191 |
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