PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,219,982 | generat homozyg taz knockout hesc line crisprca system tafazzin taz mitochondri transacylas locat chromosom x requir product mitochondri phospholipid cardiolipin mutat occur taz gene lead barth syndrom x link recess diseas general present cardiomyopathi affect male diseas model strategi base pluripot stem cell pscs provid unpreced power platform studi barth syndrom howev current studi most base male pscs result conclus neglect potenti distinct exist diseas phenotyp mechan gender studi base h cell line femal generat homozyg taz knockout taz ko human embryon stem cell hesc line employ crisprca genom edit tool femal taz ko cell line normal karyotyp robust pluripot remark reduc taz express would use tool deepli studi pathogenesi barth syndrom cardiomyopathi femal | D056889;D000066449;D009202 | T047;T025 |
36,219,981 | generat valid ipsc line bbantwi loey dietz syndrom type patient loey dietz syndrom lds autosom domin connect tissu disord major hallmark lds thorac aortic aneurysm dissect taad generat induc pluripot stem cell ipsc line sever affect lds patient carri pathogen smad parggln variant peripher blood mononuclear cell reprogram use non integr sendai viral vector autonom pluripot state result ipsc model proven presenc pluripot marker trilineag differenti potenti absenc sendai vector backbon ipsc line use studi andor therapeut target cellular pathomechan smad relat lds | D055947;D057026 | T047;T025 |
36,219,980 | effect ph interfaci foam properti maillard reaction modifi protein interfaci foam properti two conjug obtain maillard reaction determin heat time h effect coval interact lactoglobulin lg two dextran molecular weight kda evalu ph ph establish protein control mix system mix control system ph first conjug show increas surfac activ show opposit effect glycosyl process ph conjug show low surfac activ evidenc diffus constant less foam stabil observ ph compar ph relat format protein aggreg due proxim pi conjug show greater stabil ph ph respect control system due greater steric type interact forc adjac bubbl interfac could stabil glycosyl protein result indic glycosyl b lg could find use addit foam agent particular acid food | D015416;D007782 | T129;T123;T116;T070 |
36,219,979 | sarcopen obes versus sarcopenia alon use probabl sarcopenia definit sarcopenia associ frailti physic perform age bring alter bodi composit skelet muscl gradual declin accumul adipos tissu accompani although sarcopenia obes separ report associ frailti poor physic perform whether bring detriment favor effect coexist ie sarcopen obes issu need clarif aim studi associ alon frailti poor physic perform use probabl definit | D055948;D000073496 | T047;T046;T184;T033 |
36,219,978 | earli hypophosphatemia critic ill children effect parenter nutrit secondari analysi pepan rct hypophosphatemia critic ill associ advers outcom reintroduct enter parenter nutrit lead refeed hypophosphatemia rfh present potenti risk factor investig occurr earli rfh associ clinic outcom impact earli parenter nutrit pn develop earli rfh pediatr critic ill | D016638;D017674 | T047 |
36,219,977 | associ bodi mass index difficult intub doubl lumen tube retrospect cohort studi obes defin world health organ bodi mass index bmi kgm associ advers outcom challeng surgeri difficulti endotrach intub occur procedur among princip caus anesthet relat morbid mortal endotrach intub challeng obes patient due array anatom physiolog factor doubl lumen tube dlts common use airway techniqu facilit anatom isol lung one lung ventil howev dlts difficult proper posit also like caus airway injuri bleed compar convent singl lumen tube investig associ bmi difficult tracheal dlt intub | D007442;D061810 | T059;T061 |
36,219,975 | recent advanc castleman diseas castleman diseas cd encompass spectrum rare disord characterist histopatholog featur unicentr cd ucd benign local hyperplasia lymphoid tissu usual curabl multicentr cd mcd manifest potenti life threaten system diseas complex symptomatolog most due overproduct interleukin il dysregul il relat signal pathway therapeut perspect import distinguish idiopath mcd imcd case associ human herpesvirus hhv mcd | D005871;D019288 | T047;T005 |
36,219,974 | optic discrimin emulsifi oil optic complex estuarin water coastal estuari character high vari water complex optic properti pose challeng effect oil discrimin via optic remot sens studi object base spectra comparison obsc approach propos extract emulsifi oil slick balikpapan bay indonesia use optic imageri sentinel multispectr instrument msi planetscop obsc approach util spectral signatur oil emuls develop emulsifi oil index normal emulsifi oil index identifi potenti emulsifi oil object msi planetscop respect reflect spectra potenti object compar dynam select nearbi water rule fals posit detect account vari water optic properti estuari obsc approach perform well extract emulsifi oil slick optic imag moreov multipl sensor capabl oil detect compar requir detect discrimin oil spill coastal estuari environ discuss | D059392 | T069 |
36,219,973 | metagenom genom character heavi metal toler resist gene rhizospher microbiom avicennia germinan semi arid mangrov forest tropic mangrov often expos heavi metal accumul food chain generat toxic mangrov plant affect microbi divers studi determin abund gene associ resist toler heavi metal rhizospher microbiom avicennia germinan semi arid mangrov la guajira colombia metagenom genom approach twenti eight gene associ toler gene relat resist heavi metal detect gene associ toler resist cu especi cusa copa abund highest number gene toler resist zn co respect isol vibrio fluviali show abil toler cu ni zn cd work use complementari approach metagenom genom character potenti mangrov microorgan toler resist heavi metal influenc salin abund | D032407;D019216;D064307 | T002;T028;T001;T196;T032 |
36,219,972 | non correspond contamin marin surfac sediment factor arg spread sea azov present studi aim analyz level total toxic common pollut surfac sediment assess impact occurr antibiot resist gene arg sea azov biotest use whole cell bacteri lux biosensor show high integr toxic surfac sediment presenc genotoxic substanc caus oxid stress protein damag use cluster analysi shown distribut pollut sea azov depend type surfac sediment relat abund distribut arg surfac sediment shown principl compon analys result suggest non correspond contamin exert direct influenc arg abund surfac sediment sea azov thus need investig signific non correspond pollut select distribut arg aquat environ remain press problem | D000900;D004785 | T121;T131;T195 |
36,219,971 | physicochem effect calcium suppress coastal sediment resuspens coastal situ cap method sequest contamin sediment suppress sediment resuspens studi investig suppress sediment resuspens induc calcium elut situ cap materi investig physicochem suppress calcium sediment resuspens resuspens experi conduct annular flume use coastal sediment mix g csm g csm g csm g csm ca oh stepwis increas bottom shear stress calcium enhanc sediment eros resist decreas suspend sediment concentr exponenti increas ssc csm csm three time higher linear increas csm viscos csm approxim three time higher csm csm calcium induc cation exchang increas sediment viscos via sediment structur rearrang calcium silic hydrat product develop larger aggreg consequ calcium suppress sediment resuspens physiochem chang sediment properti | D019015;D002118 | T068;T121;T196;T123;T070 |
36,219,970 | second dimens retent indic normal orthogon comprehens two dimension gas chromatographi use singl standard inject generat isovolatil curv work build upon recent develop field second dimension retent indic ri use comprehens two dimension gas chromatographi gcgc expand applic common use normal orthogon column configur ri rare employ initi one dimension retent indic wastewat pollut determin gc ms mid polar zb column order determin ris peak detect wastewat extract separ gcgc ms singl inject ten compound standard mix allow construct model generat isovolatil curv curv use determin ris compound initi identifi basi mass spectral match factor ris good agreement averag deviat observ calcul ris measur refer ris compound result show approach provid addit level confid identif compound detect gcgc ms demonstr potenti approach improv compound identif non target analysi | D062065;D004785 | T069;T131;T083 |
36,219,969 | tannic acid aminopropyltriethoxysilan co deposit modifi polym membran glucosidas immobil mussel inspir catechol amin co deposit effect modif strategi various materi work polyvinyliden fluorid pvdf membran employ carrier glucosidas immobil virtu co polymer tannic acid ta aminopropyltriethoxysilan apt hydrolysi apt hierarch layer colloid nanospher coat decor surfac pvdf membran subsequ glucosidas coval bound modifi pvdf membran schiff base reaction michael addit reaction residu quinin group coat amino group enzym molecul sever paramet affect immobil procedur investig thorough morpholog function group prepar composit character scan electron microscopi sem fourier transform infrar attenu total reflect spectroscopi ftir atr x ray photoelectron spectroscopi xps combin capillari electrophoresi ce analysi perform enzym reaction kinet inhibit kinet pvdf immobil glucosidas studi immobil enzym exhibit enhanc toler temperatur ph valu addit possess good reusabl maintain initi relat activ recycl batch batch reproduc rsd n micha menten constant k immobil enzym calcul mm ic valu acarbos final pvdf immobil glucosidas appli screen potenti inhibitor kind tradit chines medicin tcms among sanguisorba radix exhibit strongest inhibitori activ posit result suggest taapt co deposit simpl mild function method chemic inert polym membran propos screen method reliabl approach discov enzym inhibitor tcms | D000520;D004800 | T121;T126;T116;T130 |
36,219,968 | click prepar chiral macrocycl base stationari phase normal phase revers phase high perform liquid chromatographi enantiosepar chiral polyimin macrocycl cpms constitut new famili organ macrocycl defin caviti rigid shape inher chiral multipl cooper bind site shown great potenti divers area howev applic cpms high perform liquid chromatographi hplc enantiosepar rare report work novel chiral stationari phase csp hplc prepar chemic bond cpm c h n onto thiolat silica via thiol ene click reaction csp exhibit good enantioselect normal revers phase hplc chiral compound includ alcohol diol keton organ acid ester ether amin epoxid enantiosepar column normal phase mode compound revers phase mode compound import broader chiral resolut observ column obtain use previous studi chiral macrocycl h l base column indic potenti signific improv broaden applic novel macrocycl type csps moreov csp exhibit good complementari enantiosepar chiralpak ad h chiralcel od h column enabl separ racem could separ two popular chiral hplc column addit fabric column exhibit good stabil reproduc relat standard deviat rsds n retent time resolut multipl inject respect result demonstr great potenti type cpm hplc separ enantiom | D012822;D000438 | T121;T109;T197 |
36,219,967 | carbon metal organ framework carbon aerogel composit effici extract triazol fungicid fruit veget improv extract effici avail stabil metal organ framework mof pipett tip solid phase extract pt spe carbon mof carbon aerogel composit cmof ca develop carbon aerogel surfac area g prepar carbon watermelon peel via hydrotherm reaction mof situ grown surfac pyrolysi c h cmof ca composit obtain regul concentr reactant seri mof ca cmof ca materi prepar materi use extract hexaconazol diniconazol fruit veget gas chromatographi flame ionize detect gc fid adsorb type amount sampl ph desorpt solvent type volum optim factor factor optim condit pt spe gc fid method establish moreov good linear concentr rang mg kg mg kg detect limit rang mg kg achiev two triazol fungicid tfs relat standard deviat n intra day inter day test rang respect method show satisfactori analyt perform differ sampl good relat recoveri rang compar method display wider linear better compar sensit enhanc analyt precis | D005659;D000073396 | T109;T131 |
36,219,956 | case report adren teratoma huge easi misdiagnos primari adren teratoma rare lesion high misdiagnosi rate view fact adren teratoma adren gland often insepar remov affect adren gland seem inevit thus necessari clinician differenti adren teratoma common adren lipoma diseas adren angiomyolipoma adren myelolipoma lipoma gangliocytoma studi report clinic patholog featur patient surgic treat adren matur teratoma hospit compar clinic characterist surgic manag literatur review case case patient femal underw open adrenalectomi laparoscop adrenalectomi respect case recurr longest follow year adren teratoma rare easi ignor misdiagnos surgeon may need adjust oper temporarili extend oper time final increas oper risk aim main help clinician rais awar adren teratoma improv diagnosi rate optim treatment decis make diseas | D000310;D018207;D013724;D008067 | T191 |
36,219,953 | vitro reconstitut hormon respons testicular organoid murin primari testicular cell increas rate male infertil requir experiment model understand mechan under male infertil vitro organoid hold unpreced promis purpos howev develop organoid tissu architectur similar testi vivo remain challeng generat testicular organoid deriv testicular cell combin hang drop cultur rotat cultur system result indic testicular cell could self assembl spheroid organoid tubul like structur hang drop cultur organoid subsequ cultur maintain rotat cultur system establish organoid gene express profil similar adult testi tissu produc testosteron preserv gonadotropin respons exhibit sensit reproduct toxic import testicular organoid generat cell maintain prolif abil freez thaw featur make possibl obtain fresh primari testi cell testicular biopsi taken patient endang wild speci build individu specif biobank find help enabl explor self organ process testicular cell provid experiment model reproduct biolog research pharmacotoxicolog test regen medicin | D013737;D007248 | T023;T184;T047;T033 |
36,219,952 | establish water energi platform via dual function photocatalyt photoelectrocatalyt system compar perspect review light driven photocatalyt pc photoelectrocatalyt pec system vital technolog extens explor wastewat treatment energi product although photo electro catalyt applic energi product wastewat remedi function similar principl photo induc charg transfer preced research focus either energi recoveri wastewat treatment two applic demand distinct reaction paramet catalyst properti present review reveal scientif progress dual function pc pec process enabl simultan energi recoveri eg h generat wastewat treatment eg degrad organ pollut key concept dual function photo electro catalyt system use electron reduct power recov h wastewat hole oxid power degrad pollut wastewat simultan herein detail comprehens overview advanc various pc pec process dual function purpos discuss highlight advantag disadvantag differ system perform comparison base divers metric tool although infanc dual function technolog gain scientif interest past year expect approach overcom multipl major environment challeng water scarciti global warm pollut review offer current limit prospect develop next generat solar driven dual function techniqu base water energi nexus | D018508;D014874 | T057;T131;T052 |
36,219,926 | non target characterist filter analysi combin silico predict strategi identifi chemic compon vivo metabolit dalitong granul uplc q tofmsm dalitong granul potent gastrointestin motil promot tradit chines medicin use treat function dyspepsia clinic show good effect allevi gastrointestin motil disord broad prospect clinic applic howev comprehens studi vivo vitro chemic analysi uplc q tof ms combin non target characterist filter analysi silico predict strategi ncfs use deduc identifi chemic compon vivo metabolit bio sampl rat follow oral administr dalitong granul studi chemic compon identifi dalitong granul includ flavonoid alkaloid terpen organ acid coumarin volatil oil plasma tissu urin fecal sampl rat administr dalitong granul total compound specul prototyp compound metabolit main metabol pathway vivo includ methyl demethyl deglycosyl hydrogen hydroxyl sulfon glucuronid mani flavonoid exist dalitong granul conclus chemic compon metabolit dalitong granul comprehens identifi use rapid accur analysi method laid foundat dissect bioactiv substanc addit provid scientif basi depth studi materi basi dalitong granul efficaci comprehens develop util | D004365;D000470 | T121;T131;T109;T123 |
36,219,924 | simpl econom three step process produc high purifi fab fragment direct egg yolk water solubl fraction although mammal still main sourc polyclon antibodi product use egg yolk immunoglobulin igi increas thus improv safeti reduc undesir reaction need remov igi constant domain pepsin enzymat treatment expect reduc potenti advers effect deriv parenter administr antibodi also increas distribut volum current fab product requir previous purif igi use start materi context relev econom benefit may gain initi igi purif could avoid use rawer start materi work three step process fab product crude egg yolk water solubl fraction describ use scalabl simpl low cost technolog ultrafiltr anion exchang chromatographi overal process yield high pure fab water solubl fraction favor compar manufactur relat medicin product mammalian antibodi antivenom | D004530;D007140 | T168;T116;T129 |
36,219,923 | develop valid ultra high perform liquid chromatographi coupl tandem mass spectrometri method quantif antileishmani drug paromomycin human skin tissu bioanalyt assay develop valid procedur perform quantifi antiprotozo drug paromomycin human skin tissu ultra high perform liquid chromatographi coupl tandem mass spectrometri paromomycin aminoglycosid drug administ intra muscular use treatment multipl clinic present neglect tropic diseas leishmaniasi current studi treatment post kala azar dermal leishmaniasi diseas leishmania parasit divid resid skin present target site bioanalyt method accur quantifi paromomycin human skin tissu clinic purpos quantifi paromomycin skin biopsi post kala azar dermal leishmaniasi patient origin sudan enzymat digest use collagenas incub c overnight employ homogen method produc skin tissu homogen sampl prepar perform protein precipit use trichloroacet acid dilut step final extract inject onto c analyt column isocrat heptafluorobutyr acid ion pair separ elut employ chromatographi system coupl tripl quadrupol mass spectromet detect method valid digest solut linear rang ngml r assay perform accuraci precis within accept criteria valu state ema guidelin furthermor matrix effect observ human skin tissu correct multipl deuter paromomycin intern standard substanti normal matrix effect detect along relat high sampl prepar recoveri consequ digest solut matrix serv prepar calibr standard use surrog matrix human skin tissu conveni given limit avail control matrix final paromomycin accur quantifi skin post kala azar dermal leishmaniasi patient origin clinic trial sudan | D007898;D000981 | T121;T047 |
36,219,919 | hydrogel complex small diamet vascular graft load tissu specif vascular extracellular matrix compon use tissu engin tissu engin thought promis strategi develop success small diamet vascular graft sdvg meet clinic demand introduct natur substanc sdvg made synthet biomateri improv biocompat promot regener sdvg vivo due natur materi differ sourc may properti deviat vital determin sourc natur materi optim sdvg fabric tissu engin applic studi bioactiv sdvgs prepar via coat heparin modifi poli caprolacton scaffold precursor solut contain vascular extracellular matrix vecm compon subsequ situ gelat mechan properti degrad behavior morpholog sdvgs thorough character evalu cell experi demonstr vitro tissu specif vecm could promot prolifer endotheli cell better skin deriv collagen furthermor three type sdvgs sdvgs blank hydrogel sdvgs skin deriv collagen sdvgs vascular extracellular matrix vecm sdvgs implant abdomin aorta rat one month explant sdvgs comprehens evalu use hematoxylin eosin masson von kossa stain immunohistochem stain cd sma mhc result show vecm sdvgs show best endothelium regener appropri intima regener calcif indic vivo specif fabric vecm sdvgs thus long term implant vecm sdvgs perform result show complet endotheli layer form month implant amount contractil smcs regen smooth muscl layer approach amount nativ aorta th month consequ reli vascular tissu specif vecm sdvgs modul regen behavior implant sdvgs vivo achiev satisfactori vascular regener short long term implant | D023822;D020100 | T061;T122 |
36,219,918 | rehabilit programm includ emg biofeedback assist pelvic floor muscl train rectus diastasi childbirth randomis control trial evalu effect comprehens rehabilit programm closur rectus diastasi rd qualiti life women deliveri | D017773;D011788 | T078;T023 |
36,219,915 | moment arm anatom subregion rotat cuff muscl flexion rotat cuff rc muscl act forc coupl stabil glenohumer joint enabl shoulder motion investig moment arm anatom subregion supraspinatus ssp infraspinatus isp subscapulari ssc tere minor muscl flexion eight fresh frozen cadaver shoulder obtain anatom subregion rc muscl identifi sutur secur subregion musculotendin junction excurs flexion increment measur use digit system kruskal walli test follow bonferroni post hoc test use assess differ subregion within singl muscl signific differ moment arm subregion rc muscl p lt anterior superfici middl subregion ssp muscl present posit flexor decreas moment arm increas flexion posterior deep subregion show moment arm posit decreas valu negat extensor moment arm larger angl subregion isp show posit almost constant moment arm throughout rang motion tere minor present negat almost unalt moment arm superior middl subregion ssc show posit decreas moment arm increas angl flexion negat moment arm toward end rang inferior subregion present negat moment arm throughout flexion result indic posterior deep subregion ssp muscl seem act flexor earli rang stabil mid end rang flexion | D017006;D012785 | T023;T030 |
36,219,914 | systemat review patient level meta analysi radiofrequ ablat medic refractori epilepsi implic clinic practic research radiofrequ thermocoagul rf tc minim invas procedur treatment epilept foci aim studi review avail evid safeti efficaci rf tc medic refractori epilepsi | D000069279;D000078703 | T061;T047 |
36,219,913 | diurnal rhythm spontan intracrani high frequenc oscil seizur known occur diurnal rhythm gain insight neurophysiolog period seizur test hypothesi intracrani high frequenc oscil hfos show diurnal rhythm sleep wake cycl variat hypothes hfos differ rhythm within outsid seizur onset zone soz | D004569;D000069279 | T047;T060;T034 |
36,219,906 | signal enhanc strategi ratiometr aptasens aflatoxin b plasmon modul competit photoelectrochemistri driven electrochemistri driven redox methylen blue effici signal amplif use light irradi electrochemistri base sens attract grow interest howev modul electrochem photoelectrochem behavior bifunct probe remain challeng better analyt perform found bifunct probe methylen blue mb irradi follow two rout ie photoelectrochemistri pec driven electrochemistri ec driven rout plasmon modul competit pec driven ec driven rout effici enhanc analyt perform aptasensor ferrocen label aptam fc apt appli tune interact mb label complementari dna mb cdna plasmon gold nanoparticl aunp visibl light illumin aptasensor output weak current mb mb depress ec driven redox bind fc apt target led strip electrod releas mb cdna approach aunp increas mb observ due synergi depress pec driven redox restor ec driven redox way amplifi respons target could obtain depress background signal enlarg respons signal mb visibl light consequ develop model ratiometr aptasensor offer higher sensit determin aflatoxin b observ favor shed light photo induc electrochem mechan propos amplif strategi valuabl construct effici sensor | D052157;D015374;D053768 | T059;T075;T073;T114 |
36,219,894 | improv accuraci nonpoint sourc pollut estim inland water coupl satellit uav data quantit accur analyz nonpoint sourc nps pollut essenti effici prevent input nps load inland water howev accuraci previous nps pollut model limit accuraci ground paramet data addit effect method thorough verifi model result larg scale paper present framework accur nps pollut estim coupl satellit unman aerial vehicl uav monitor data result verifi field sampl newli develop inlet nps pollut observ simul method fraction veget coverag fvc data obtain satellit use improv accuraci runoff modul framework satellit uav data coupl acquir livestock data determin inlet identifi reservoir buffer zone veget type new data use improv accuraci livestock runoff modul framework result show estim accuraci total nitrogen total phosphorus ammonia nitrogen chemic oxygen demand fvc improv relat error respect high resolut livestock data acquisit improv estim accuraci nps pollut load high resolut inlet extract improv accuraci high resolut buffer zone identif improv accuraci estim nps pollut concentr reservoir decreas final high resolut veget type identif improv accuraci framework perform satisfactorili verifi base simul nps observ averag relat error found fvc livestock number inlet number key paramet nps pollut model introduct month variat fvc make model nps pollut load much higher area matur complex forest ecosystem dens distribut veget much lower area spars distribut veget method provid scientif refer high effici nps pollut prevent inland water lay solid basi decis make regard water qualiti manag data scarc region around world | D004785;D014874 | T131 |
36,219,893 | speci english channel adjac area uncov impact isotop marin pathway radioact iodin releas la hagu nuclear fuel reprocess facil nrf english channel distribut transform isotop speci environment consequ fulli character channel present data iodin isotop speci surfac water english channel southern celtic sea compar speci concentr io show variat iodat major speci data provid new inform regard iodid iodat inter convers show water dilut mix main factor affect speci distribut channel reduct iodat occur within english channel main west part biotic process speci transform overal insignific especi eastern channel constant valu io observ might character la hagu wastewat signal celtic sea oxid iodid trace speci larger scale general experienc oxid process atlant ocean coast shallow shelf sea new produc identifi especi german bight baltic sea data speci english channel provid estim redox rate much broader marin area transit time la hagu well defin furthermor estim inventori speci channel flux speci english channel north sea add import inform geochem cycl | D014875;D013964 | T191;T131;T196 |
36,219,891 | anthelmint intox goat sheep systemat review object studi conduct research literatur avail electron media anthelmint intox sheep goat search primari studi carri five electron databas sciencedirect pubm scopus web scienc scielo search term use antihelmint antiparasit vermifug poison toxic overdos intox goat sheep total articl identifi five databas scienc direct n pubm n scopus n web scienc n scielo n articl found duplic left review titl abstract read full includ systemat review articl involv sheep involv goat involv speci twelv drug identifi intox report albendazol closantel disophenol ivermectin levamisol moxidectin netobimin nitroxinil oxfendazol parbendazol tetramizol thiabendazol preval symptom anthelmint intox report show involv nervous locomotor renal system well teratogen influenc data review underscor need care requir control parasit infect safe use antiparasit drug avoid case intox | D012757;D000871;D015511 | T121;T047 |
36,219,889 | multi res interfac improv read without central vision loss sharp foveal vision inher macular degener md sever impact read one strategi preserv patient read abil involv one one serial visual present svp word wherebi word view extrafov howev method limit patient often retain natur tendenc foveat word thus bring word scotom region addit svp offer compens fact orthograph input degrad outsid fovea address issu test novel interfac wherein text present word word multipl repetit multi res word display simultan around fovea hypothes multi res setup would lead reader make fewer detriment eye movement recogn word faster consequ multipli orthograph input use eye track simul gaze conting foveal scotoma normal sight particip read word either classic svp multi res mode line hypothes read drastic better multi res condit faster recognit fewer saccad increas oculomotor stabil surmis multi res method good potenti improv read central vision loss classic svp techniqu | D011932;D012607 | T056;T184;T033 |
36,219,886 | addit autolog platelet rich plasma semen extend enhanc cryotoler fertil capac buffalo bull spermatozoa platelet rich plasma prp extens use regen medicin present work aim investig effect autolog prp supplement semen freez extend sperm qualiti antioxid capac lipid peroxid vitro fertil capac frozen thaw buffalo semen subsequ embryo development compet buffalo bull n use semen donor semen ejacul separ divid four equal part extend autolog prp control supplement tris base semen extend extend semen sampl cool c h process cryofreez french straw post thaw semen sampl c evalu progress motil pm structur membran integr smi function membran integr fmi total abnorm ta acrosom integr ai supernat thaw sampl examin colormetr superoxid dismutas activ sod total antioxid capac tac lipid peroxid profil mda fertil capac post thaw spermatozoa cryofrozen prp extend test upon fertil buffalo oocyt vitro higher p post thaw sperm qualiti pm smi fmi ai prp semen extend wherea ta lower control concentr five percent prp supplement semen extend result greater p tac sod lesser mda level compar group insemin buffalo oocyt sperm cryofrozen prp reveal higher fertil cleavag blastocyst rate lower polyspermi compar control conclus buffalo spermatozoa cryofrozen autolog prp supplement semen extend enhanc cryotoler fertil potenti | D012662;D053657 | T059;T058;T031 |
36,219,885 | tumor microenviron redox dual stimuli respons polymer nanoparticl effect cisplatin base cancer chemotherapi serious side effect cisplatin hinder clinic applic nanotechnolog might potenti strategi address limit howev rapid clearanc blood circul ineffect control drug releas nanocarri hamper therapeut efficaci nano deliveri system construct tumor microenviron redox dual stimuli respons nano deliveri system peg c bpei ss pt cross link disulfid contain polymer conjug bpei ss pt dialdehyd group modifi peg via schiff base optim cross link time h select get nano deliveri system h nmr drug releas assay show acid tumor microenviron ph schiff base broken detach peg cross link outer shell display capabl releas drug sequenti ph redox respons manner moreov peg c bpei ss pt show effect anti tumor therapeut efficaci vivo signific side effect compar drug cisplatin use clinic strategi highlight promis platform dual stimuli respons profil achiev better therapeut efficaci minor side effect platinum base chemotherapi | D053758;D009369 | T191;T073 |
36,219,883 | turnaround time predict clinic chemistri sampl use machin learn turnaround time tat essenti perform indic medic diagnost laboratori accur tat predict crucial take time action case prolong tat import effici organ healthcar object develop model accur predict tat focus autom pre analyt analyt phase | D002624;D000069550 | T091;T066 |
36,219,882 | enantioselect imin reduct dihydro carbolin fe thiosquaramid catalyst enantioselect imin reduct dihydro carbolin dhbcs reliabl power tool construct bioactiv chiral tetrahydro carbolin thbcs report effici enantioselect imin reduct employ situ generat fe thiosquaramid fe tsqs b asymmetr organometal catalyst produc chiral thbcs h catalyst mol found suitabl substrat alkyl aryl group afford correspond chiral thbcs excel enantioselect ee | D007097;D002243 | T109 |
36,219,878 | anti tuberculosi drug use direct observ treatment short cours dot schedul alter endocrin pattern reduc ovarian reserv oocyt qualiti mous tuberculosi one major infecti diseas peopl reproduct age group high risk infect | D065851 | T042 |
36,219,877 | congenit anomali spontan abort mice result use escitalopram escitalopram esc use pregnanc associ teratogen effect fetus | D000014;D000022 | T047;T046;T019;T033 |
36,219,868 | tlr inhibit suppress growth oestrogen induc prolactinoma model prolactinoma harm effect human health bromocriptin commerci avail drug china prolactinoma patient respond clinic pathogenesi remain unknown thus pathogenesi need determin develop new therapeut method prolactinoma express er tlr prolactin prl pituitari gland cbl mice human prolactinoma specimen examin immunofluoresc immunohistochemistri role tlr prolactinoma determin use estradiol induc model cbl wild type tlr mice mmq cell treat estradiol fulvestr lipopolysaccharid lps transfect tlr sirna studi express er tlr prl cell furthermor interact er tlr investig immunoprecipit analysi express prl tlr co locat increas pituitari gland mice human prolactinoma specimen compar control specimen meanwhil tlr knockout treatment tlr inhibitor tak signific inhibit tumor overgrowth also decreas express prl estradiol treat mice p mapk pathway regul howev mmq treat estradiol lps enhanc prl express treat estradiol lps alon final er tlr inhibit prevent estradiol induc prl increas regul tlrp mapk pathway vitro estradiol promot prolactinoma develop activ tlrp mapk pathway er tlr potenti therapeut target prolactinoma treatment | D010911;D015175 | T191 |
36,219,867 | nonmalign ar posit prostat epitheli cell cancer cell respond differ androgen prostat cancer research suffer lack suitabl model studi role normal cell prostat carcinogenesi address challeng develop cell line model mimick lumin prostat epitheli cell modifi immort prostat epitheli cell line rwpe constitut express androgen receptor ar rwpe ar cell express known ar target gene exhibit coexpress lumin basal marker characterist transient amplifi cell rna signatur resembl prostat lumin progenitor cell unstimul condit constitut ar express biolog signific effect prolifer rwpe cell stimul androgen growth retard transcript respons rwpe ar cell androgen stimul involv suppress growth relat kras pathway thus mark differ prostat cancer cell line lncap deriv ar overexpress lncap arhi cell growth cancer relat pathway upregul henc nonmalign ar posit rwpe ar cell line model could use studi transform prostat epithelium | D011467;D011471 | T191;T023 |
36,219,848 | insight molecular mechan egcg apigenin disrupt amyloid beta protofibril base molecular dynam simul fibril deposit amyloid beta protofibril one import factor lead alzheim diseas molecular dynam simul offer inform intermolecular interact mechan protofibril fibril inhibitor work explor earli molecular mechan epigallocatechin gallat egcg apigenin disrupt protofibril base molecular simul bind mode egcg apigenin protofibril obtain furthermor compar behavior mechan egcg apigenin disturb protofibril egcg apigenin abl decreas proport sheet bend structur protofibril induc random coil structur result hydrogen bond k salt bridg illustr egcg apigenin abil destabil protofibril meanwhil van der waal interact egcg protofibril shown larger apigenin protofibril electrostat interact apigenin protofibril domin bind affin find may help design effect drug candid disord protofibril imped fibril | D056004;D000544 | T047;T044;T066;T048 |
36,219,847 | one bioderiv air permeabl sweat stabl mxene epiderm electrod muscl theranost muscl fatigu common symptom experienc mani peopl associ less maxim forc product fatigu muscl high desir simultan imperceiv diagnos muscl fatigu restor muscl function use one skin electrod yet electrod develop far herein report one bioderiv air permeabl sweat stabl mxene electrod concurr comfort record electromyograph emg signal achiev electrostimul electrotherm therapi muscl theranost leverag structur arrang perenni herb ion cross link mxene sweat mxene base electrod mbe exhibit high breathabl ultralightweight mgcm low stabl electrod skin interfaci imped varieti environ facilit long term reliabl monitor electrophysiolog taken togeth electrostimul electrotherm therapi skin surfac mbe diagnos muscl fatigu restor muscl function stimul blood circul addit also use muscl rehabilit train prosthesi control via human comput interact one bioderiv air permeabl sweat stabl mxene electrod great potenti daili wearabl healthcar muscl fatigu | D013542;D057285 | T061;T091;T031 |
36,219,840 | nih catalyz proxim select hydroamin unactiv alken anthranil regioselect hydroamin unactiv alken long stand challeng organ synthesi herein report nih catalyz proxim select hydroamin unactiv alken aminoquinolin aq bident auxiliari anthranil amin reagent wide rang primari aryl amin bear ortho carbonyl group instal termin intern unactiv alken deliv varieti valuabl amino acid build block respect excel regiocontrol util transform demonstr convers multifunction aryl amin use n heterocycl | D000475;D000588 | T109 |
36,219,835 | predict covid infect municip netherland algorithm develop interpret covid first identifi decemb citi wuhan china virus quick spread declar pandem march infect symptom fever dri cough nasal congest fatigu develop case virus caus sever complic pneumonia dyspnea could result death virus also spread rapid netherland small dens popul countri age popul health care netherland high standard nevertheless problem hospit capac number avail bed staff also region municip hit harder other netherland import data sourc avail daili covid number inform municip | D000086382 | T047;T067 |
36,219,834 | bifunct amin thiol modifi ti c x mxene trace detect heavi metal surfac function two dimension transit metal carbid nitrid carbonitrid also known mxene power approach modif physic chemic properti new applic studi demonstr synthesi bifunct ti c x mxene modifi amin thiol group facil condens reaction success employ result nh sh ti c x mxene solid phase ultrason assist dispers micro solid phase extract spe method analyt determin heavi metal trace level food soil sampl prepar nh sh ti c x mxene show remark perform ultrason assist spe method limit detect ng ml linear dynam rang g l g l cadmium cd lead pb ion respect furthermor extract effici greater relat standard deviat less five separ batch experi determin g l cd pb studi show nh sh ti c x use simpl rapid reliabl select sensit materi spe method trace determin cd pb soil agricultur product studi demonstr util mxene analyt chemistri suggest advanc method function mxene open new applic alreadi excit materi | D002104;D019216 | T131;T196 |
36,219,832 | vaccineswork hashtag twitter context covid pandem network analysi vaccin one success public health intervent prevent covid toward end april unicef unit nation intern children emerg fund alongsid organ promot hashtag vaccineswork | D000086382;D061108 | T047;T170;T067 |
36,219,830 | dynam intramolecular cap preserv metallodrug integritya case catalyt fluoroquinolon librari eight new fluoroquinolon nucleas conjug contain guanidinoethyl aminoethyl auxiliari pendant cyclen moieti design synthes investig potenti overcom general issu metallodrug vulner physiolog condit cu ii co iii complex new design compound synthes potenti oper dynam intramolecular cap dnase activ explor lead co iii cyclen ciprofloxacin conjug show excel vitro hydrolyt dnase activ retain presenc strong endogen chelat exhibit enhanc antibacteri activ relat metal free ligand absenc adjuv therebi demonstr proof concept vitro ex vivo respect dynam cap hypothesi lead conjug nick supercoil plasmid dna within fluoroquinolon gyras dna ternari complex therebi disabl function gyras new mode action previous report fluoroquinolon | D024841;D000080027 | T109;T123;T195 |
36,219,829 | prolin residu regul gaba r gate loop interact interfac region cys loop receptor superfamili transmembran pentamer receptor play crucial role mammalian cns signal physiolog activ receptor typic initi neurotransmitt bind orthoster bind site locat extracellular domain ecd lead open channel pore gate transmembran domain tmd wherea consider knowledg molecular mechan cys loop receptor activ gather acetylcholin receptor littl known respect gaba receptor gaba r mediat cellular inhibit import sever static structur gaba r recent describ pave way depth molecular function studi moreov point tmd ecd interfac region play crucial role transduct conform chang ligand bind site channel gate one interfac structur implic transduct process loop high conserv prolin p residu address issu specif l gaba r choos substitut prolin p amino acid differ physicochem featur electrostat charg abil chang loop flexibl address function impact mutat perform macroscop singl channel patch clamp analys togeth model find reveal mutat p weak affect agonist bind critic transit gaba r gate openingclos preactiv desensit conclus provid evid conserv p interfac strong involv regul receptor gate | D015640;D011392 | T043;T123;T116 |
36,219,826 | effect n alkyl side chain amid water interact amid water interact influenc structur function amid base system protein homopolym particular n alkyl amid unit appear play critic role defin interact amid group previous studi link thermal behavior amid base polym natur n alkyl side chain howev connect chemic structur n alkyl hydrat amid remain elus studi solvat structur dynam amid differ n alkyl group investig use combin linear nonlinear infrar spectroscopi comput method interest dynam amid local environ slow n alkyl side chain becom bulkier rather speed comput calcul confirm hydrat dynam assign effect smaller amplitud faster rotat bulkier group also observ experiment hydrogen bond make break water amid carbonyl direct relat size n alkyl side chain bulkier n isopropyl substitu present signific slower chemic exchang dynam smaller chain ethyl methyl two small group present major differ hydrogen bond make break dispar similar among group well model theori demonstr n alkyl group affect amid hydrat structur dynam via steric effect summari result present show size n substitut alkyl group signific influenc hydrat dynam amid stress import consid effect much larger system polym | D000577;D014867 | T121;T109;T197 |
36,219,825 | one step ligand exchang method produc quantum dot dna conjug dna direct self assembl address current challeng make bright stabl small dna function quantum dot qds develop one step ligand exchang method produc qd dna conjug common avail hydrophob qds show systemat adjust reaction condit ligand nanoparticl molar ratio ph solvent composit stabl high photoluminesc water solubl qd dna conjug relat high ligand load produc moreov site specif bind qd dna conjug dna origami templat demonstr bioconjug suffici colloid stabil dna direct self assembl fluoresc quench adjac gold nanoparticl aunp demonstr qd aunp dimer may serv biosensor improv sensit reproduc moreov simpl method facilit assembl qds complex superlattic discret cluster may enabl novel photophys properti | D045663;D053768 | T073 |
36,219,824 | yeast cell surfac engin nicotinamid ribosid kinas product nicotinamid mononucleotid via whole cell catalysi nicotinamid mononucleotid nmn wide use nutraceut self medic one step convers nicotinamid ribosid nr nmn consid promis synthet rout nmn human nicotinamid ribosid kinas nrk function display cell surfac saccharomyc cerevisia ebi form whole cell biocatalyst whole cell nrk whole cell nrk could convert nicotinamid ribosid nr nmn effici presenc atp mg maxim activ iug dri weight k similar free nrk report previous get best reaction condit nmn synthesi amount nr atp mg use ph temperatur synthet reaction optim use whole cell nrk catalyst optim condit nmn synthes nr reach maxim convers rate correspond gl nmn reaction mixtur much higher synthet process report addit whole cell nrk good ph stabil thermost requir complic treatment use could reus sequenti product therefor studi provid safe stabl high effect low cost biocatalyst prepar nmn great potenti industri product | D009537;D012441 | T004;T114 |
36,219,822 | develop chiral supercrit fluid chromatographi tandem mass spectrometri revers phase liquid chromatographi tandem mass spectrometri platform quantit metabol profil octadecanoid oxylipin octadecanoid broad defin oxylipin ie lipid mediat deriv carbon fatti acid contrast well studi eicosanoid lack analyt method octadecanoid hamper investig field develop integr workflow combin chiral separ supercrit fluid chromatographi sfc revers phase liquid chromatographi lc coupl tandem mass spectrometri detect quantif broad panel octadecanoid platform includ custom synthes analyt intern standard extend coverag octadecanoid synthet pathway total octadecanoid could separ chiral sfc complex enantiosepar could perform lloq rang ngml sfc ngml lc averag accuraci solvent surrog matrix rang sfc lc wherea coeffici variat cv medium high concentr low concentr valid surrog matrix show neglig matrix effect analyt averag recoveri rang combin method provid platform investig biolog activ octadecanoid expand understand littl studi compound | D025924 | T059 |
36,219,821 | solvent induc swell behavior microphas separ polystyren block poli ethylen oxid thin film investig use situ spectroscop ellipsometri singl molecul fluoresc microscopi block copolym attract consider interest field nanosci nanotechnolog polym afford well defin nanostructur via self assembl depth understand solvent effect physicochem properti microdomain crucial prepar util herein employ situ spectroscop ellipsometri singl molecul fluoresc techniqu gain detail insight microdomain properti polystyren block poli ethylen oxid ps b peo film expos ethanol water satur n observ quick increas subsequ gradual decreas ellipsometr thick ps b peo film upon exposur ethanol satur n observ unexpect ethanol satur n induc neglig thick chang ps peo homopolym film similar maximum thick gain observ ethanol water satur n impli swell peo microdomain ethanol vapor permeat peo microdomain support redshift ensembl singl molecul fluoresc emiss nile red ps b peo film singl molecul track data show initi enhanc subsequ reduct diffus hydrophil sulforhodamin b molecul ps b peo film upon exposur ethanol satur n consist spectroscop ellipsometri result higher ethanol suscept peo microdomain attribut amorph natur shown ftir data | D011137;D005027 | T109;T131;T122 |
36,219,819 | develop systemat strategi toward promot synuclein aggreg use hydroxyisophthalamid base system establish potent scheme synuclein aggreg involv parkinson diseas evalu promis rout identifi compound either inhibit promot aggreg process synuclein last two decad perspect guid dramat increas effort focus develop potent drug either retard promot self assembl process synuclein address issu use chemic kinet platform develop strategi enabl progress detail analysi molecular event lead protein aggreg microscop level presenc recent synthes hydroxyisophthalamid class small organ molecul base bind affin furthermor qualit develop strategi disintegr synuclein fibril presenc organ molecul final shown organ molecul effect suppress toxic synuclein oligom neuron cell | D051844;D010300 | T047;T123;T116 |
36,219,818 | dynam situ confin trigger ligand free neuropeptid receptor signal membran receptor cluster fundament cell cell communic howev physiolog function receptor cluster cell signal remain enigmat develop dynam platform induc cluster format neuropeptid hormon receptor r situ chelat nanotool multival interact enabl dynam exchang histidin tag r within cluster fast r enrich cluster area trigger ligand independ signal determin increas cytosol calcium cell migrat notabl calcium motil respons ligand induc activ amplifi preclust cell suggest key role receptor cluster sensit dose respons lower ligand concentr ligand independ versus ligand induc signal differ bind arrestin downstream effector recruit cluster presenc ligand approach allow situ receptor cluster rais possibl explor differ receptor activ modal | D009478;D006639 | T121;T123;T116 |
36,219,812 | associ hormon therapi chang object sleep qualiti women late menopaus transit sleep disord preliminari studi aim studi investig chang object sleep qualiti hormon therapi ht women late menopaus transit | D007319;D012893 | T047;T184;T048 |
36,219,811 | interact nutrient intak comorbid qualiti life premenopaus postmenopaus women studi aim identifi associ nutrient intak health relat qualiti life hrqol premenopaus postmenopaus women | D011788;D017698 | T078;T040 |
36,219,804 | congress extend enhanc aca subsidi congress extend enhanc marketplac subsidi adopt histor medicar prescript drug reform | D058991;D055553 | T121;T089 |
36,219,802 | longitudin effect combin antiretrovir therapi cognit neuroimag biomark treatment naiv peopl hiv combin antiretrovir therapi cart dramat increas life expect peopl hiv pwh near develop hiv associ neurocognit disord may due previous uncontrol hiv viral replic immun activ maintain residu viral replic activ sourc cart associ neurotox aim studi determin effect cart cognit neuroimag biomark pwh initi cart compar hiv negat control hcs hiv elit control ec remain untreat | D023241;D015658 | T061;T047 |
36,219,798 | pearl oy ster revers postpartum pseudocoma state associ magnesium therapi report case magnesium mg compet calcium normal synapt transmiss inhibit neurotransmitt releas drug usual given treatment eclampsia preeclampsia two eclampt pregnant women treat mg develop pseudocoma state immedi emerg caesarian section clinic present flaccid quadriparesi areflexia absent respiratori effort vestibular ocular reflex preserv pupillari respons decrement respons repetit nerv stimul found women recoveri obtain cessat mg persist pupillari reflex absenc reflex involv striat muscl import clinic clue indic neuromuscular junction dysfunct | D008274;D011225 | T046;T123;T196 |
36,219,797 | effect antiseizur medic duotherapi patient glioma multicent observ cohort studi patient glioma need add antiseizur medic asm due uncontrol seizur asm monotherapi studi aim determin whether levetiracetam combin valproic acid lev vpa common prescrib duotherapi effect duotherapi combin includ either lev vpa patient glioma | D005910;D010889 | T191;T109;T121 |
36,219,796 | associ ultraprocess food consumpt risk dementia prospect cohort studi grow bodi evid associ consumpt ultraprocess food upf advers health outcom includ depress cardiovascular diseas caus mortal howev whether upf associ dementia unknown author investig associ upf dementia incid uk biobank | D015140 | T047 |
36,219,787 | plan prevent parkinson diseas time parkinson diseas pd chronic progress neurodegen diseas increas worldwid preval despit mani trial neuroprotect therapi manifest pd diseas modifi therapi establish past sever decad seri breakthrough identifi discret popul substanti increas risk develop pd base knowledg time design implement pd prevent trial endeavor build experi gain earli prevent trial alzheim diseas huntington diseas articl first review prevent trial preced neurodegen diseas focus critic design element pd prevent trial includ enrol trial therapeut test measur outcom prevent trial perspect reflect progress remain challeng motiv confer plan prevent parkinson trial design symposium workshop | D000544;D006816;D019636;D010300 | T047;T048 |
36,219,779 | identif arylheteroaryl amino quinolon potent membran disrupt agent combat antibiot resist gram posit bacteria nosocomi infect caus resist gram posit organ rise presum due combin factor includ prolong hospit exposur increas use invas procedur pervas antibiot therapi although antibiot stewardship infect control measur help newer agent multidrug resist mdr gram posit bacteria urgent need describ effort led identif amino quinolon except potent gram posit activ minimum inhibitori concentr mic gml numer clinic isol preliminari mechan action resist studi demonstr amino quinolon bacteriostat select resist select disrupt bacteri membran precis molecular mechan elucid lead compound nontox display therapeut index greater devoid hemolyt activ attract physicochem properti clog p molecular weight mw warrant investig promis antibacteri scaffold treatment gram posit infect | D000900;D015363 | T121;T109;T195 |
36,219,773 | aldosteron chronic kidney diseas renal outcom random control trial demonstr efficaci mineralocorticoid receptor mr antagon delay chronic kidney diseas ckd progress diabet howev investig role aldosteron whether benefici effect could achiev individu without diabet | D003920;D051436 | T047 |
36,219,769 | high select mof base probe turn luminesc detect al cr fe solut test paper strip absorb caus enhanc mechan trival metal ion cr al fe constitut major section environment pollut excess accumul detriment effect health detect trace quantiti hot topic research high scalabl porous zn base luminesc metal organ framework mof synthes exploit mix ligand synthesi concept strateg select aromat conjug organ linker n rich spacer contain azin function metal ion bind site immobil across pore space made mof ideal turn sensor al cr fe ion high sensit select recycl depth studi reveal absorb caus enhanc mechan ace respons turn phenomena order make detect process straightforward conveni portabl econom viabl fabric mof test paper strip mof could simpli immobil onto paper strip nake eye visual detect uv light thus manifest potenti real time smart sensor trival ion | D004785;D000073396 | T109;T131 |
36,219,766 | direct construct peak free induct decay curv gas chromatographi molecular rotat reson spectroscopi without fourier transform concept coupl gas chromatographi molecular rotat reson spectroscopi gc mrr introduc combin separ capabl gc unparallel specif mrr studi address challeng high data throughput mrr spectromet gc mrr spectromet generat thousand million data point per second previous gc mrr studi free induct decay fid measur fourier transform generat point chromatogram extens calcul limit perform sensit speed gc mrr direct approach propos extract peak intens fid use gram schmidt vector orthogon method first analyt free fid use construct basi set repres instrument background nois remain fid orthogon fix basi set fid yield singl intens valu gram schmidt orthogon magnitud orthogon analyt fid signal intens plot chromatogram approach comput much faster time convent fourier transform algorithm least sensit ft algorithm maintain improv chromatograph peak shape compar sensit linear chromatograph peak shape fourier transform gram schmidt approach use synthet generat fid instrument data approach would allow sum peak intens display essenti real time follow identifi peak investig identifi quantifi speci associ | D000465 | T170 |
36,219,763 | methan activ mononuclear copper activ site zeolit mordenit effect metal nuclear reactiv direct convers methan methanol would wide reach environment industri impact copper contain zeolit perform reaction low temperatur pressur previous defin activ cu site howev autoreduct copper contain zeolit mordenit remov cu activ site zeolit still methan reactiv studi use diffus reflect uv vis spectroscopi magnet circular dichroism reson raman spectroscopi electron paramagnet reson x ray absorpt spectroscopi unambigu defin mononuclear cuoh ch reactiv activ site autoreduc zeolit rigor identif mononuclear activ site allow reactiv comparison previous defin cu activ site perform kinet experi compar reactiv cuoh cu site find binuclear site signific reactiv analysi densiti function theori calcul elucid increas reactiv direct result stabil cu oh h atom abstract product electron deloc two cu cation via bridg ligand signific increas reactiv electron deloc binuclear activ site provid new insight design high reactiv oxid catalyst | D017641 | T197 |
36,219,758 | intravascular laser irradi blood improv function independ subacut post stroke patient retrospect observ studi post stroke acut care center taiwan object investig effect intravascular laser irradi blood ilib patient post stroke disabl background helium neon intravascular laser wavelength nm appli post stroke rehabilit mani year taiwan data collect practic valid effect materi method singl center retrospect observ studi data patient first episod ischem stroke particip post acut care program initi modifi rankin scale mrs score juli june retrospect review twelv patient receiv convent rehabilit plus ilib ilib group twenti two patient receiv convent rehabilit control group assess includ mrs barthel index bi berg balanc scale bbs min walk test mwt fugl meyer assess upper extrem fma ue perform evalu post treatment improv result patient receiv ilib signific superior mrs score receiv convent rehabilit p patient ilib group experienc improv bi mwt fma ue howev nonsignific addit control group experienc greater improv bbs ilib group studi requir elucid mechan action ilib therapi fulli major advers event report patient receiv ilib therapi conclus ilib improv independ post stroke patient suggest ilib promis treatment facilit post stroke recoveri | D000085542;D020521 | T047;T033 |
36,219,757 | sexual transmit diseas relat reddit post covid pandem latent dirichlet alloc analysi sexual transmit diseas stds common cost impact approxim peopl annual reddit sixth use internet site world user generat social media discuss platform may use monitor discuss std symptom exposur | D000086382;D061108;D012749 | T047;T170;T067 |
36,219,754 | chatbot support young peopl covid pandem new zealand evalu real world rollout open trial number young peopl new zealand aotearoa experi mental health challeng increas aotearoa went initi covid lockdown ongo digit mental health project adapt underw rapid content author creat aroha chatbot dynam digit support design young peopl help manag pandem relat worri | D000086382 | T047;T067 |
36,219,750 | photobiomodul prevent therapi recurr herp labiali year vivo random control studi object present studi aim evalu effect applic photobiomodul therapi pbmt prevent recurr herp labiali rhl random control clinic trial background data rhl lifelong infect effect patient qualiti life literatur pbmt shown posit result prevent rhl decreas recurr sever lesion despit good result report still control clinic studi publish subject method studi volunt recruit random divid three studi group laser jpoint lj n laser jpoint lj n placebo jpoint n treatment consist protocol session throughout month year follow posttreat result result show lj present satisfactori result concern reduct number lesion per year less sever recurr long term evalu compar lj laser group lj lj statist effici placebo aspect analyz patient receiv laser treatment lj lj present recurr signific improv frequenc andor sever lesion patient side effect treatment conclus pbmt effect reduct frequenc recurr rhl sever postirradi lesion may appear | D006560;D028022 | T061;T047 |
36,219,747 | effect photobiomodul therapi treatment myofasci pain syndrom upper trapezius muscl systemat review meta analysi object systemat review aim investig efficaci photobiomodul therapi pbmt pain pressur pain threshold ppt patient myofasci pain syndrom mps upper trapezius muscl materi method total studi patient includ data regard particip intervent paramet outcom measur time measur follow extract evalu methodolog qualiti perform physiotherapi evid databas pedro scale grade recommend assess develop evalu grade system use assess qualiti evid meta analysi perform studi standard mean differ smd correspond confid interv ci overal effect size es calcul result meta analysi use random effect model perform evalu effect pbmt alon pbmt plus exercis ex compar placebo medic treatment physic therapi pt modal manual therapi complementari pt assess accord pedro scale reveal high qualiti fair qualiti low qualiti studi accord grade system studi exhibit low medium qualiti evid medium es smd ci studi use pbmt alon larg es smd ci pbmtex conclus present system review reveal pbmt effect pt modal reduc pain increas ppt patient mps upper trapezius pbmt combin ex signific effect reduc pain increas ppt compar control low qualiti studi low moder qualiti evid limit confid effect estim recommend high qualiti studi standard treatment protocol irradi paramet prospero registr number crd | D064171;D028022;D009209 | T061;T023;T184;T047 |
36,219,738 | develop risk stratif tool predict opioid relat respiratori depress non cardiac surgeri retrospect studi accur assess probabl signific respiratori depress follow opioid administr potenti enhanc periop risk assess pain manag develop valid risk predict tool estim probabl signific respiratori depress index naloxon administr patient undergo noncardiac surgeri | D000701;D012131 | T047;T046;T131;T121;T109 |
36,219,737 | situ simul emerg medicin safe scope review provid overview avail evid regard safeti situ simul iss emerg depart ed | D004635 | T091 |
36,219,734 | alter extracellular matrix colorect carcinoma background process prolifer invas tumor cell depend chang extracellular matrix ecm activ enzym alter profil ecm compon aim investig mrna protein express profil ecm compon heparanas hpse heparanas hpse matrix metalloproteinas mmp syndecan sdc neoplast nonneoplast tissu patient colorect carcinoma crc test associ express pattern gene presenc absenc lymph node metastas materi method cross section studi adult patient crc admit resect surgeri analyz mrna protein express pattern hpse hpse mmp sdc gene quantit revers transcript pcr immunohistochemistri respect addit investig whether variat exist express ecm compon affect tissu nontumor tissu collect patient tissu sampl collect surgic resect result conclus data show higher mrna protein express level hpse p mmp p sdc p tumor sampl compar adjac non neoplast tissu howev increas hpse protein level tumor tissu increas express hpse observ patient lymph node metastasi p elev hpse mrna express patient lymph node metastas potenti indic may particip drive colorect carcinoma progress | D020780;D015179 | T191;T126;T116 |
36,219,731 | live macrophag deliv tetrapod pdh nanoenzym target atherosclerosi manag ros scaveng hydrogen anti inflamm autophagi activ atherosclerosi driven chronic inflamm arteri wall under sever sever cardiovascular diseas howev current avail anti inflammatori base strategi atherosclerosi treatment suffer compromis therapeut efficaci undesir therapeut outcom herein distinct tetrapod needl like pdh nanozym design engin effici atherosclerosi treatment combinatori reactiv oxygen speci ros scaveng hydrogen anti inflamm autophagi activ load macrophag target deliveri arteri plaqu multifunct nanozym effici decreas ros level signific suppress inflamm relat patholog process exert distinct antioxid anti inflammatori perform allevi atherosclerosi develop especi import specif spiki morpholog pdh nanoenzym trigger strong autophagi respons macrophag synergist maintain cellular homeostasi allevi atherosclerosi develop vitro vivo result confirm synergi among antioxid anti inflammatori autophagi activ suggest combinatori engin nanomedicin intrins multipl therapeut function topolog induc biolog effect high prefer effect achiev high therapeut perform desir therapeut outcom atherosclerosi manag therapi | D006859;D050197 | T047;T046;T196 |
36,219,730 | kio mediat c sp h sulfenyl enaminon metal free regioselect c sp h sulfenyl enaminon heterocycl thiol report transform effici mild scalabl environment friend toler larg varieti enaminon substrat heterocycl thiol util strategi demonstr late stage modif bioactiv natur product drug deriv | D013438;D001688 | T121;T109;T123 |
36,219,727 | consider prevent intraop fluid spillag airway bronchogen cyst anesthesia case report patient bronchogen cyst spillag cyst content airway anesthesia surgeri report method prevent complic definit year old man larg bronchogen cyst schedul cyst excis larg quantiti purul fluid spill airway immedi induct anesthesia due unmask exist communic cyst bronchial tree preoper percutan drainag cyst content awak intub lung isol bronchial blocker paralyz posit patient may help | D000758;D001994 | T061;T019 |
36,219,726 | flux balanc analysi mobil crispri guid delet condit essenti gene shewanella oneidensi mr carbon neutral product valuabl bioproduct critic sustain develop remain limit slow engin photosynthet organ improv exist synthet biolog tool engin model organ fix carbon dioxid one rout overcom limit photosynthet organ work describ pipelin enabl delet condit essenti gene shewanella oneidensi mr genom oneidensi simpl bacteri host could use electr driven convers carbon dioxid futur genet engin use flux balanc analysi fba model carbon energi flow central metabol assess effect singl doubl gene delet model growth delet strain sever altern condit identifi substrat restor viabil otherwis lethal gene knockout predict test vivo use mobil crispri gene knockdown system inform learn fba knockdown experi inform strategi gene delet allow us success delet expect essenti gene gpma fba predict knockdown experi support delet confirm essenti gene gpma need surviv depend medium use remov gpma first step toward drive electrod power co fixat via rubisco work demonstr potenti broaden scope genet engin oneidensi synthet biolog chassi combin comput analysi crispri knockdown system way one systemat assess impact condit essenti gene use knowledg generat mutat previous thought unachiev | D020043;D020592 | T007;T028 |
36,219,725 | sever polyethylen glycol allergi consider periop manag case report patient sever polyethylen glycol peg allergi face broad challeng especi present hospit surgeri peg use often excipi medic medic suppli although rare allergi increas report like underdiagnos present patient known past anaphylact reaction peg detail account periop cours broad provid recommend resourc safe manag similar patient sever peg allergi | D000707;D011092 | T047;T046;T121;T109;T130 |
36,219,724 | chiral induc spin select heterochir short peptid carbon nanotub hybrid network role supramolecular chiral supramolecular short peptid assembl wide use develop biomateri potenti biomed applic peptid self assembl multitud chiral hierarch structur trigger applic differ stimuli chang temperatur ph solvent etc self assembl process sensit chemic composit peptid affect specif amino acid sequenc type chiral result supramolecular chiral materi explor modul protein cell interact recent signific attent focus develop chiral materi potenti spintron applic shown transport charg carrier chiral environ polar carrier spin effect name chiral induc spin select ciss studi differ chiral organ molecul materi well carbon nanotub function chiral molecul nevertheless effect primarili explor homochir system chiral medium henc result spin polar defin chiral molecul limit option tunabl herein develop heterochir carbon nanotub short peptid materi made combin two differ chiral sourc homochir peptid ld glucono lacton show presenc small amount glucono lacton fix chiral alter supramolecular chiral medium therebi modul sign spin signal vice versa addit small amount glucono lacton even induc nonzero spin polar otherwis achir spin inact peptid nanotub composit chiral dope strategi could allow develop complementari ciss base spintron devic circuit singl materi platform | D037742;D045333 | T116;T104;T073 |
36,219,723 | associ pre oper hydroxi vitamin defici surgic site infect right hemicolectomi surgeri background surgic site infect ssi one import cost complic surgic oper present studi hypothes vitamin defici associ increas risk ssi current studi investig hypothesi patient method prospect cohort studi perform adult patient undergo open right hemicolectomi oper stapl anastomosi februari march surgeri ward imam khomeini hospit logist regress test examin analyz connect serum oh vitamin level post oper wound infect result studi compris particip met inclus criteria pre oper serum vitamin level ngml particip ngml particip mean serum vitamin level ngml among studi popul increas vitamin defici link elev odd surgic wound infect incid among patient surgeri odd ratio confid interv ci p conclus pre oper vitamin level strong affect post oper ssi patient colon cancer studi highlight import conduct research determin possibl advantag vitamin prevent incis infect surgeri | D013530;D014808 | T047;T046 |
36,219,717 | tast associ learn rat condit immunosuppress cyclosporin studi neuro immun network pharmacolog effect immunosuppress drug cyclosporin csa learn retriev human anim appli associ learn paradigm principl base pavlovian condit repeat present uncondit stimulus us drug csa pair exposur condit stimulus cs novel tast saccharin exposur cs later time lead avoid behavior concomit use paradigm anim expos cs saccharin display immunosuppress reflect reduc splenic cell prolifer diminish interleukin interferon express releas ex vivo cultur splenocyt mimick pharmacolog effect us csa notabl paradigm tast immun associ learn demonstr impress abil brain detect store inform organ immunolog status retriev inform therebi modul immunolog function via endogen pathway moreov condit pharmacolog effect obtain mean associ learn success implement control drug dose reduct strategi support treatment option optim pharmacolog treatment effect patient benefit howev knowledg under neurobiolog immunolog mechan mediat learn immunomodulatori effect still limit reliabl anim model tast immun associ learn provid novel insight peripher central nervous process articl describ protocol focus basic tast immun associ learn paradigm csa saccharin rat condit peripher immunosuppress determin ex vivo cultur splenocyt behavior protocol reliabl adapt may pave road futur studi use tast immun associ learn paradigm gain deeper insight brain immun system communic author current protocol publish wiley period llc basic protocol tast immun associ learn cyclosporin basic protocol splenocyt isol cultiv studi stimul induc cytokin product | D016572;D013649 | T121;T042;T116 |
36,219,716 | small molecul push erythroidmegakaryocyt cell specif boundari combin mekerk signal inhibitor three chromatin remodel molecul enhanc generat platelet produc megakaryocyt vitro possibl direct reprogram | D002843;D008533 | T025;T116 |
36,219,715 | intern societi stem cell research isscr annual meet celebr year achiev last june stem cell communiti came togeth celebr th anniversari intern societi stem cell research isscr one lead organ field hybrid event mix vari program fill plenari talk concurr track session poster present exhibit booth plenti opportun enhanc stem cell research bond academia industri report highlight plenari session main topic discuss speaker impress research showcas meet genuin proof great advanc field wit last year come | D057905 | T062 |
36,219,714 | synthet embryo complet gastrul initi organogenesi ex utero development biolog revolution two recent articl show synthet mous embryo deriv embryon stem cell esc grown ex vivo complet gastrul organogenesi stage remark achiev never attain use stem cell studi use transcript factor reprogram extraembryon cell combin naiv esc cultur aggreg use gas exchang bioreactor allow aggreg proceed gastrul organogenesi resembl e stage mous embryo advanc synthet embryo allow model challeng stage mammalian develop translat find human pluripot system may allow product rare cell type engin therapi | D004622;D054262 | T018;T040 |
36,219,713 | past present futur direct cell reprogram bud broader development biolog stem cell research field cellular reprogram establish promin disciplin right direct cell reprogram defin cell fate convers somat cell toward anoth ident without pluripot intermedi state addit opportun mechanist dissect lineag commit human cell field offer promis divers applic diseas model cell replac therapi regen medicin immunotherapi recent spur innov box think unleash potenti cellular plastic | D065150;D057026 | T043;T062;T025 |
36,219,711 | inject allograft adipos matric manag chronic postop wound retrospect analysi clinic option lack manag chronic wound ulcer follow fail debrid skin graft negat pressur wound therapi dress | D017719;D016523;D054843 | T061;T047;T074 |
36,219,710 | reconstruct axillari defect propel parascapular flap resect patient advanc hidraden suppurativa wide excis affect skin tissu apocrin glandular region standard treatment advanc hs various flap type use coverag | D003286;D017497;D061525;D019651 | T061;T047;T190;T023 |
36,219,709 | atyp ulcer stepwis approach clinician chronic ulcer associ signific morbid mortal typic ulcer due venous insuffici diabet ischemia pressur lymphedema chronic ulcer respond standard therapi reevalu potenti atyp etiolog atyp ulcer less common difficult diagnos due wide rang possibl etiolog includ inflammatori autoimmun neoplast vasculopathi hematolog infecti drug induc extern standard approach manag complex atyp ulcer exist review stepwis approach atyp ulcer propos aim assist physician identif diagnosi perfus adequ sign infect author recommend obtain ulcer biopsi microbiolog dif histopatholog evalu criterion standard diagnosi laboratori test includ autoimmun panel hypercoagul panel infecti diseas panel aid diagnosi atyp ulcer often requir multidisciplinari care input specialist rheumatolog dermatolog infecti diseas wound care vascular surgeri hematolog oncolog effect communic within health care team essenti accur diagnosi manag atyp ulcer activ dialogu provid improv consult effici ultim lower cost care | D003141;D014647 | T047 |
36,219,706 | telehealth servic implic enhanc sexual transmit infect prevent unit state sexual transmit infect stis among persist threat health equiti increas access sti prevent control servic provis remot health telehealth improv sexual health outcom telehealth shown increas access care even improv health outcom increas flexibl offer telehealth servic accommod patient provid although telehealth remot health strategi import sti prevent share common attribut circumst overlap articl focus specif consider telehealth contribut increas health equiti offer import complement case substitut person sti servic popul telehealth assist varieti differ popul includ experienc sti dispar howev although internet offer promis resourc mani american household increas percentag american use mani resourc person equal access internet addit tailor sti program accommod uniqu patient popul program like face adapt servic fit reimburs licens regul | D012749;D017216 | T047;T058 |
36,219,699 | nonequilibrium amyloid polym exploit dynam coval linkag tempor control charg select catalysi extant protein exploit thermodynam activ negat charg coenzym hydrotrop tempor access mechanist import conform regul vital biolog function metabol reaction express modul herein show short amyloid peptid bind small molecular coenzym exploit revers coval linkag polymer access catalyt profici nonequilibrium amyloid microphas subsequ hydrolysi activ coenzym lead depolymer realiz varianc surfac charg assembl function time tempor chang surfac charg dynam modul catalyt activ transient assembl observ high evolv modern day biocatalyst | D011108;D000682 | T104;T123;T116;T122 |
36,219,697 | vega platform unsuit mammalian direct evolut direct evolut use cycl gene diversif select generat protein novel properti tradit direct evolut perform prokaryot system recent mammalian direct evolut system viral evolut genet actuat sequenc vega describ report vega system major limit preclud use direct evolut deconstruct sindbi virus sinv genom compris vega system could longer promot sindbi structur gene ssg depend viral replic moreov viral particl generat use vega system rapid lost target direct evolut transgen instead cheater particl primarili contain rna encod sinv structur compon aros sequenc found contamin came rna provid initi sinv packag rna deriv vega system note structur rna target transgen use vega system contain viral packag sequenc impact sinv cheater particl could potenti overcom context robust vega circuit sinc ssg complement also defect vega system select authent evolut product current possibl similar result obtain independ laboratori taken togeth result show vega system work describ without signific redesign use mammalian direct evolut campaign | D012845;D014771 | T026;T005 |
36,219,695 | shine visibl light reduct elimin acridin pd catalyz cross coupl aryl halid carboxyl acid despit recent tremend progress transit metalphotoredox dual catalysi organ synthesi singl transit metal catalysi visibl light irradi util light energi effici still underdevelop herein report design photosensit phosphinoacridin bident ligand visibl light induc transit metal catalysi expect electron accept acridin moieti would creat high reactiv electron defici metal center toward reduct elimin via metal ligand charg transfer mlct use ligand achiev palladium catalyz cross coupl reaction aryl halid carboxyl acid visibl light irradi electron tune phosphinoacridin ligand enabl use varieti aryl halid coupl partner includ less reactiv aryl chlorid blue light irradi also realiz employ lower energi green red light cross coupl experiment mechanist studi prove reduct elimin aryl ester induc photoirradi phosphinoacridin ligat arylpalladium ii carboxyl complex theoret calcul suggest reduct elimin excit state promot decreas electron densiti pd center photoinduc intramolecular electron transfer ie mlct transit state owe electron defici acridin scaffold rare exampl photoinduc reduct elimin palladium ii complex | D010165;D009942 | T109;T196 |
36,219,694 | gaucher diseas unusu caus knee pain gaucher diseas gd genet lysosom disord lead storag glycolipid molecul glucocerebrosid macrophag caus multiorgan dysfunct bone marrow involv may result pain bone crisi hematolog disturb | D005776 | T047 |
36,219,693 | prenat exposur matern social disadvantag psychosoci stress neonat white matter connect birth earli life advers social disadvantag psychosoci stressor associ alter microstructur fronto limbic pathway import socioemot develop understand associ begin emerg may inform time design prevent intervent longitudin studi mother oversampl low incom complet social background measur pregnanc measur analyz structur equat analysi result two latent factor social disadvantag educ insur status incom need ratio inr neighborhood depriv nutrit psychosoci stress depress stress life event racial discrimin birth healthi term born neonat underw diffus mri dmri scan mean diffus md fraction anisotropi fa measur dorsal inferior cingulum bundl cb uncin fornix use probabilist tractographi fsl social disadvantag psychosoci stress fit dmri paramet use regress model adjust infant postmenstru age scan sex social disadvantag psychosoci stress independ associ lower md bilater inferior cb left uncin right fornix lower md higher fa right dorsal cb result persist account matern medic morbid prenat drug exposur moder analysi psychosoci stress associ lower md left inferior cb among lower higher socioeconom status ses inr group extrem low ses inr group increas access social welfar program reduc burden social disadvantag relat psychosoci stressor may import target protect fetal brain develop fronto limbic pathway | D011297;D066127 | T023;T024;T037 |
36,219,692 | sharp turn gyrotaxi modul surfac accumul microorgan accumul swim microorgan surfac essenti featur various physic chemic biolog process confin space date accumul main assum depend chang swim speed angular veloc caus cell wall contact hydrodynam interact measur swim trajectori heterosigma akashiwo biflagel marin alga near vertic horizont rigid boundari observ probabl sharp turn great increas near vertic wall result signific chang distribut averag swim speed angular veloc rotat diffus near wall quantiti previous investig function distanc wall swim orient satisfactorili explain standard hydrodynam model detail examin individu cell trajectori show wall contact lead flagellum trigger complex chang behavior flagella incorpor mechanist model individu base model predict cell concentr use measur distribut swim speed angular veloc rotat diffus agre well experi experi model repeat cell suspens vertic plane bound horizont wall cell accumul beneath wall expect gyrotaxi consider amplifi cell wall interact find may shed light predict control cell distribut mediat gyrotaxi cell wall contact | D005407;D008954 | T026;T075 |
36,219,684 | macrophag present antigen allerg asthma resid macrophag mediat antigen captur present allerg airway inflamm mice | D001249 | T047 |
36,219,683 | endocannabinoid produc photoreceptor cell respons light activ drosophila trp channel drosophila phototransduct model signal cascad culmin activ transient receptor potenti trp cation channel trp trpl canon trp trpc channel regul light stimul rhodopsin engag g q phospholipas c plc lipid metabolit generat downstream plc essenti activ trpc channel photoreceptor cell sought identifi key lipid produc subsequ plc stimul contribut channel activ use genet lipid analysi ca imag found light increas amount abund endocannabinoid linoleoyl glycerol lg vivo increas lg amount depend plc diacylglycerol lipas encod norpa ina respect endocannabinoid facilit trpc depend ca influx heterolog express system dissoci ommatidia compound eye moreov lg mechan stimul cooper activ trpc channel ommatidia propos lg physiolog relev endocannabinoid activ trpc channel photoreceptor cell | D029721;D050051 | T123;T116 |
36,219,682 | n glycan c domain jag import notch activ canon member jaggedserr delta famili transmembran ligand extracellular amino termin c domain bind phospholipid requir optim activ notch receptor somat mutat caus amino substitut c domain human jag jag identifi tumor found report cell assay mutat affect n glycosyl site reduc ligand abil activ notch n glycosyl site locat c domain conserv jaggedserr famili lack delta famili site specif glycan analysi jag amino terminus demonstr occup site either complex type high mannos n glycan requir full notch activ report cell assay similar jag variant defect notch bind n glycan remov either mutagenesi glycosyl site endoglycosidas treatment reduc receptor activ n glycan variant also reduc receptor activ notch signal depend vascular smooth muscl cell differenti assay loss c n glycan reduc jag bind liposom similar extent loss entir c domain molecular dynam simul suggest presenc n glycan limit orient jag relat membran thus facilit notch bind data consist critic role n glycan promot lipid bind conform requir orient jag cell membran full notch activ | D000070538;D008081 | T109;T087 |
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