PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,220,298 | n covsel new strategi featur select n way data data analysi select meaning variabl hot wide debat topic sever variabl select featur reduct approach propos literatur although featur select method numer suitabl data matric higher order structur main due fact assess relev variabl multi way context extens discuss best knowledg among variabl select approach develop standard way data array vip analysi select ratio extend higher order structur aspect given irrelev topic contrari possibl select inform complex data set multi way structur crucial light consider present paper discuss featur select strategi n way data base covari select covsel approach thus call n covsel method allow select featur differ dimension n way depend natur origin data array novel method appli simul data set order inspect abil select featur compat ground truth system real data set case n covsel demonstr abl select meaning featur eventu differ strategi analysi select featur propos base sequenti multi block method provid data reduct n pls base respect multi way natur data | D016018 | T081 |
36,220,297 | seed mediat situ growth phototherm reagent gold nanostar mechan studi preliminari assay applic phototherm reagent mediat portabl detect platform use thermomet signal reader receiv extens attent due simplic low cost practic howev exploit phototherm reagent excel phototherm convers effect conveni synthes prefer without modif biosens applic still challeng herein simpl rapid seed mediat situ synthesi strategi develop prepar gold nanostar aunss remark phototherm convers effect simpli chang seed size compon concentr involv situ synthesi process aunss adjust geometri allow phototherm convers tune high level optim biosens meanwhil accur understand phototherm convers mechan obtain studi relationship morpholog aunss phototherm effect subsequ use ascorb acid aa model target preliminari applic aunss construct portabl phototherm detect platform demonstr situ prepar strategi aunss exhibit remark phototherm convers effect also avoid complic time consum synthesi modif therefor great potenti extend portabl detect target simpli convert concentr target aa | D006046;D053768 | T121;T196;T073 |
36,220,296 | novel miniatur passiv sampl devic base liquid phase microextract equip cellulos graft membran environment monitor phthalic acid ester natur water phthalic acid ester pae consid endocrin disruptor potenti carcinogen consequ effici accur environment monitor trace level organ pollut necessari protect popul hazard effect passiv sampl techniqu gain notorieti environment monitor proven high sensit tempor variat studi develop miniatur passiv sampl devic mpsd base hollow fiber liquid phase microextract hf lpme devic calibr laboratori use autom calibr system result demonstr first order uptak rang diethyl phthalat dep diisobutyl phthalat dibp dibutyl phthalat dbp benzyl butyl phthalat bbp bis ethylhexyl phthalat dehp min h sampl rate equival ml h respect r calibr devic deploy margin lagoon stretch approxim km along main river extract recov devic analyz gas chromatographi gc result identif quantif dep ng l dibp ng l dbp ng l bbp ng l dehp ng l despit frequent identifi dehp concentr well maximum establish limit reveal good water qualiti term target pae contrast screen extract use gcxgc possibl detect hazard pollut pesticid drug metabolit describ devic effect reliabl provid accur pae measur follow short exposur period sens deploy emerg oper accident discharg industri effluent natur water could continu cost effect monitor water qualiti | D004051;D052244;D004785;D059627;D010575;D010795 | T059;T131;T122;T109;T039 |
36,220,295 | cerium ion trigger dual readout immunoassay base aggreg induc emiss effect tetramethylbenzidin fluoresc colorimetr detect ochratoxin ochratoxin ota one preval toxic mycotoxin ultrasensit conveni detect ota urgent demand public health work dual readout immunoassay establish detect ota base ce oxid tetramethylbenzidin tmb ce induc aggreg induc emiss aie au nanoclust aunc alkalin phosphatas alp ascorb acid phosphat aap form ascorb acid aa dephosphoryl aa reduc ce generat ce induc aie aunc enhanc fluoresc intens aunc meanwhil unreact ce oxid tmb form blue oxtmb thus dual readout immunoassay develop base aie aunc tmb substrat limit detect lod low ngml fluoresc assay ngml colorimetr assay recoveri ota corn fluoresc mode colorimetr mode result verifi cerium ion trigger dual readout immunoassay reliabl sensit detect ota corn sampl | D002563;D009793 | T121;T131;T109;T196 |
36,220,294 | portabl miniatur mercuri analyz use direct sampl inbuilt metal ceram electrotherm vapor work small size inbuilt metal ceram heater imch first time util solid sampl electrotherm vapor etv novel direct sampl mercuri analyz coupl miniatur atom absorpt spectromet therebi fabric sensit determin mercuri soil mercuri analyz main compos imch etv catalyt pyrolysi furnac cpf use al particl new filler atom absorpt spectromet aa miniatur air pump carrier gas herein most use gold amalgam cancel imch w heat fulfil vapor mercuri mg soil sampl use l min air carrier optim condit method detect limit lod ng g mg sampl rsd repeat measur gss soil certifi refer materi crm furthermor measur hg valu various soil crms real soil sampl within certifi valu consist use chines standard method solid sampl catalyt pyrolysi aa gold amalgam recoveri prove favor analyt accuraci precis fabric instrument occupi kg w power consumpt vs kg w tradit hg analyz therefor propos imch etv aa method suitabl portabl rapid detect mercuri soil | D008628 | T131;T196 |
36,220,293 | hyphen temperatur gradient elut refract index detect temperatur respons liquid chromatographi refract index detect rid attract allow approach benefit univers detect liquid chromatographi ideal standard independ calibr henc compound independ quantif becom possibl nevertheless implement rid remain limit offer poor detect sensit compat isocrat mobil phase implement composit solvent gradient remain prohibit challeng commerci hplc rid system due result drastic alter refract index extrem baselin drift refract index also high depend temperatur leeway appear possibl mitig problem particular use temperatur gradient limit temperatur respons liquid chromatographi trlc allow obtain isocrat revers phase type separ wherebi retent modul via temperatur chang c c polym convers temperatur elut profil reminisc obtain solvent gradient convent rplc obtain enact downward temperatur gradient column work compris proof principl illustr possibl combin thermal gradient trlc rid observ baselin drift appear therebi minor nriu min henc easili control short chain fatti acid use repres compound assess new approach overlap calibr line accord obtain fatti acid butyr decano acid | D011108;D012031 | T059;T104;T081;T122 |
36,220,292 | use tube extract slice select nmr experi allow imag via statist analysi metabol profil imag distribut metabolit power diagnost also employ fundament research although nmr spectroscopi well establish determin metabol profil biolog sampl applic limit magnet reson imag produc imag larger structur number detect metabolit low mass spectrometri imag hand well establish pixel size rang limit analysi larger structur like tissu section detect metabolit depend ionize properti high resolut nmr metabolom could complement method howev prevent due time consum extract procedur overcom limit follow protocol establish appli two differ ham slice sampl direct done nmr tube extract polar non polar metabolit nmr tube slice select nmr spectra acquir multivari analysi pca nmr spectra subsequ visual differ correl well structur visibl ham slice propos protocol use metabol imag could complement imag method | D055442;D055432 | T091;T039;T070 |
36,220,291 | visibl fluoresc sens cu ion urin reusabl chitosanl histidin stabil silicon nanoparticl integr thin layer chromatographi sheet studi report facil approach fabric chitosan cs biopolym l histidin l biomolecul stabil self assembl silicon nanoparticl sinp sens cu ion approach method yield nm size csl sinp particl high stabil harsh ph temperatur condit besid csl sinp high select copper amongst differ metal ion test fe mg al cr cr cu mn cd pb zn hg ca li po compar blank sinp lod cs sinp lod l ligand enhanc sensit csl sinp toward cu remark lod valu nm applic csl sinp evalu coat csl sinp thin layer chromatographi tlc sheet csl sinp tlc sheet exhibit signific sens capac toward cu ion detect rang make suitabl site analysi cu ion environment clinic sampl final cu sens practic csl sinp tlc sheet challeng real human urin sampl express csl sinp tlc sheet could regener use ethylenediaminetetraacet acid edta without lose photost reus | D048271;D008628;D053758 | T073;T131;T121;T109;T196 |
36,220,290 | multipl crrnas assist crisprcasa assay target cytochrom b gene amplif free detect meat adulter cluster regular interspac short palindrom repeat crispr cas system wide appli nucleic acid analysi high specif coupl pre amplif step sensit crispr base detect great improv howev extra pre amplif step complic detect procedur may also caus aerosol contamin process transfer amplifi solut crispr system studi demonstr combin multipl crrnas crisprcasa system enhanc detect sensit base establish multipl crrnas enhanc crispr mecrispr method appli meat adulter identif take cytochrom b cyt b gene target mecrispr method direct detect low ngl extract pork dna ww pork contamin pork beef meat mixtur cross reaction extract chicken beef duck fish dna mecrispr reaction incub isotherm temperatur detect process complet design portabl apparatus heat block light emit diod filter simplic specif suffici sensit mecrispr method great prospect speci identif food adulter genet modifi food detect | D045303;D009696 | T126;T123;T116;T114 |
36,220,289 | semi enclos paper sensor high sensit select detect prolin current studi util semi enclos leak proof microfluid paper base analyt devic pad modifi isatin conjug chitosan specif colorimetr reagent detect prolin prolin one global accept stress biomark plant also one promin amino acid present wine process food quantif prolin regular requir agricultur field food wine industri specif interact isatin prolin uniform film form abil chitosan result uniform color presenc leak proof layer prevent diffus colorimetr reagent deeper result enhanc color signal intens reaction zone util imag pad captur use smartphon print imag box hous smartphon pad platform util smartphon flash uniform illumin ensur constant posit pad captur imag great enhanc sensit accuraci platform compar previous publish high sensit multi layer paper base platform detect prolin current method enhanc detect rang fold compar limit detect moreov develop pad platform reduc optimum reaction temperatur time compar previous work develop paper base platform util evalu prolin content young arabidopsi plant subject water stress day devis paper base method potenti applic site evalu various stress plant | D017360;D048271;D007510 | T121;T109;T130;T002 |
36,220,288 | multipurpos e bioplatform target kv channel whole cancer cell evalu potenti therapeut potassium ion channel express cell membran implic wide varieti cell function intim link cancer cell behavior work report first bioplatform describ date allow simpl rapid detect ion channel activ effect inhibitor cancer cell methodolog involv interrog channel interest cell specif captur magnet immunoconjug use specif detect antibodi label horseradish peroxidas enzym channel activ reflect amperometr signal transduct result magnet bioconjug onto screen print carbon electrod bioplatform feasibl proven detect kv channel u human glioblastoma cell block scorpion venom kaah kaah peptid obtain result confirm high sensit detect u cellsml g ml kaah propos bioplatform versatil detect potassium channel activ potenti inhibitor given cancer cell line high sensit simpl fast way bioplatform present potenti applic cancer theranost channelopathi | D018796;D009369;D012604 | T116;T131;T121;T191;T123;T129 |
36,220,287 | electrochem sensor appli zro nitrogen dope three dimension porous carbon nanocomposit effici detect ultra trace hg ion studi zro nitrogen dope three dimension porous carbon zro n dpc nanocomposit manufactur fabric effect electrochem sensor detect ultra trace mercuri ion hg synthes n dpc open pore structur larg specif surfac area enough continu mass transfer channel facilit diffus transmiss electron ion sens interfac provid effect adhes platform electrochem deposit zro nanoparticl benefit synergist effect zro n dpc develop electrochem sensor good adsorpt catalyt perform hg wider linear rang g l lower detect limit g l meanwhil sensor exhibit remark repeat reproduc stabil anti interfer appli detect hg seafood tap water satisfactori recoveri lower relat standard deviat propos strategi electrochem sens detect hg provid new idea direct research zro n dpc nanocomposit field analysi detect also great signific ensur food environment safeti human health | D055664;D008628;D053761 | T059;T131;T196;T073 |
36,220,286 | toward visual chiral recognit amino acid use wide rang color tonal ratiometr nanoprob chiral recognit long challeng issu deal biolog system drug design food authent implement nanoparticl base probe intrins induc chiral field address sever issu concern sensit reliabl rapid cost chiral sens platform yet research chiral nanoprob use visual monitor chiral substanc still infanc part studi visual chiral recognit platform develop combin blue emit carbon dot bcds mercaptopropion acid cap cdte quantum dot mpa qds inher chiropt activ employ enantiomer detect ratiometr probe display uniqu fluoresc respons pattern presenc arginin arg histidin enantiom upon addit l amino acid success enhanc quench emiss intens well red shift emiss wavelength mpa qds observ emiss color nanoprob chang green pink red green brick red red increas concentr l arg l respect contrast amino acid equival neglig influenc emiss color fluoresc signal develop nanoprob due enantioselect vibrant color chang nanoprob rgb analysi appli determin enantiomer excess ee racem mixtur satisfactori result allow smartphon base onsit visual evalu ee circular dichroism lifetim size distribut potenti measur employ studi chiroselect respons first principl calcul also carri densiti function theori dft confirm experiment observ furthermor chiroselect respons pattern ratiometr nanoprob manipul construct logic gate system mimick inhibit function capabl propos chiral platform visual monitor fraction enantiom racem mixtur great potenti rapid onsit visual discrimin chiral compound field clinic diagnost drug analysi | D019187;D045663 | T073;T197 |
36,220,285 | sensit nir mitochondria target fluoresc probe visual viscos live cell mice mitochondria powerhous cell provid energi need cellular activ howev abnorm mitochondri microenviron eg increas viscos lead mitochondri dysfunct diseas herein develop seri near infrar nir fluoresc probe detect viscos screen probe cq select sinc show great fluoresc enhanc fold nir window specif respons viscos influenc ph polar biolog speci stimul monensin nystatin cq measur cellular viscos chang good biocompat addit observ increas viscos starvat cq appli distinguish cancer cell normal cell base viscos differ furthermor probe success appli imag viscos inflam tumor bear mice vivo therefor cq may contribut futur studi viscos physiolog patholog process | D005456;D008985 | T109;T130;T195 |
36,220,284 | activat self assembl organ nanotheranost aspartyl aminopeptidas trigger nir fluoresc imag guid photothermalphotodynam synergist therapi phototherapi develop power method remedi modal convent photosensit alway state lack tumor target contribut poor therapeut effect high toxic therefor develop aspartyl aminopeptidas dnpep activ self assembl organ nanoparticl nrh asp nps sensit extern irradi induc phototherm therapi photodynam therapi pttpdt nrh asp nps activ nrh nh nps dnpep demonstr strong near infrar nir fluoresc effici generat heat singlet oxygen near infrar laser nrh asp nps success use visual dnpep vitro vivo nir region demonstr good synergist anti cancer efficaci pdt ptt result suggest dnpep mediat nrh asp nps promis candid imag guid phototherapeut tumor | D053758;D009369 | T191;T073 |
36,220,282 | druggabl sitespocket p dnaja protein protein interact silico model vitroin vivo valid mutat p common genet alter human cancer vast major p mutat found cancer missens mutat singl nucleotid point mutat lead accumul mutant p protein potenti gain oncogen function mechan stabil accumul missens mutant p protein malign cell fulli understood thought dnaja play crucial role co chaperon protein stabil mutant p amplifi oncogen potenti identifi small molecul inhibitor disrupt protein protein interact mutant p dnaja may lead effect treatment prevent carcinogenesi studi protein protein interact identifi potenti druggabl hotspot histor limit protein protein bind site requir complex character singl protein crystal structur mani protein identifi due issu identifi salient druggabl target protein protein interact bench research may take year complet howev silico model approach allow rapid character protein protein interfac druggabl bind site contain chapter first review oncogen potenti mutant p crucial role dnaja stabil missens mutant p detail methodolog use silico model molecular biolog identifi druggabl protein protein interact sitespocket mutant p dnaja final discuss screen valid util small molecul inhibitor identifi silico framework specif describ gy uniqu compound activ mutant p demonstr therapeut potenti inhibit cancer cell growth vivo vitro | D009369;D016159 | T191;T123;T116 |
36,220,281 | synthesi glcnacyl small heat shock protein protein structur function often depend primari sequenc also presenc absenc number non code posttransl modif complic studi fact physiolog consequ modif context protein site depend exist pure biolog techniqu unambigu studi effect end protein semisynthesi becom invalu chemic biolog tool specif instal non code non nativ moieti onto protein vitro use synthet andor recombin polypeptid describ two facet protein semisynthesi solid phase peptid synthesi express protein ligat use generat site specif glycosyl small heat shock protein function studi procedur herein requir limit special equip employ mild reaction condit extend myriad protein modif context | D050888 | T123;T116 |
36,220,280 | two dimension electrophoresi cellular thermal shift assay de cetsa target identif bioactiv compound identif target molecul new bioactiv compound still challeng drug develop various proteom base method develop analyz interact compound target protein among method cellular thermal shift assay cetsa frequent appli recent year valid studi compound protein interact use antibodi combin cetsa comprehens proteom analysi success narrow target new compound enorm number protein cell chapter introduc de cetsa combin cetsa proteom analysi use two dimension electrophoresi method identif target protein | D020543;D040901 | T091;T123;T116 |
36,220,279 | vitro cellula method determin target protein sumoyl post translat modif ptms provid critic mean calibr function proteom thus extens util eukaryot exert spatio tempor regul cellular machineri rapid ubiquitin phosphoryl exampl well document ptms sumoyl revers conjug small ubiquitin relat modifi sumo specif lysin residu target protein bear strike similar ubiquitin follow enzymat cascad attach sumo target protein unlik ubiquitin sumoyl modul target protein structur stabil activ local interact thus sumoyl regul cellular event signal transduct cell cycl progress transcript nucleocytoplasm transport stress respons accord deregul sumoyl avenu diseas make investig sumo substrat within cell essenti howev low extent sumoyl pose signific challeng detect sumo modif within cell bioinformat tool help predict sumoyl mass spectrometr analysi identifi pool cellular protein sumoylom nevertheless biochem method observ enhanc level vitro sumoyl help valid protein sumoyl critic lysin util process effect substrat protein function chapter provid detail account biochem method common util detect sumoyl protein central understand biolog function mechan regul sumo target | D008239;D058207 | T121;T044;T123;T116 |
36,220,278 | linchpin direct precis label lysin nativ protein purif analysi protein critic build block live system serv tool investig intervent precis engin enabl tune expand function landscap among various proteinogen amino acid high frequenc lysin offer promis bioconjug target howev also among challeng candid homogen singl site modif linchpin direct modif ldm address concern offer chemoselect site select modular protein bioconjug protocol outlin general method singl site modif nativ protein first select ldm reagent construct stabl bioconjug acyl lys side chain subsequ chemic orthogon handl creat opportun instal desir probe direct altern group enabl bioconjug enrich order immobil subsequ releas coupl probe instal render analyt pure singl site tag protein bioconjug analysi construct involv intact ms protein bioconjug peptid map ms ms site modif homogen | D008239;D011506 | T121;T123;T116 |
36,220,277 | nanoluciferas base cell fusion assay rapid high throughput assess sar cov neutral antibodi patient sampl two year covid still repres global health burden unpreced extent assess degre immun individu sar cov remain challeng virus neutral assay repres gold standard assess antibodi mediat protect sar cov sera recov andor vaccin individu neutral antibodi block interact viral spike protein human angiotensin convert enzym ace receptor vitro prevent viral entri host cell classic viral neutral assay use full replic compet virus restrict specif biosafeti level certifi laboratori limit util routin larg scale applic develop therefor cell fusion base assay build interact viral spike ace receptor express two differ cell line substanti reduc biosafeti risk associ classic viral neutral assay chapter describ simpl sensit safe cost effect approach rapid high throughput evalu sar cov neutral antibodi reli high affin nanoluc luciferas complement technolog hibit appli varieti standard patient sampl method yield high reproduc result well well well format use novel nanoluc substrat increas signal stabil like nano glo endurazin furthermor allow high flexibl assay set full automat read process last assay suitabl evalu neutral capac sera exist spike variant potenti variant emerg futur | D000085962;D000086382 | T067;T047;T126;T116 |
36,220,276 | reconstitut biochem studi extend synaptotagmin mediat lipid transport extend synaptotagmin e syt famili lipid transfer protein ltps locat endoplasm reticulum er plasma membran pm contact site eukaryot cell possess conserv synaptotagmin like mitochondri lipid bind protein smp domain two five c domain membran tether function e syt well studi divers speci recent studi reveal mammalian e syt yeast homolog tricalbin tcb could transport lipid oppos membran mechan studi suggest syt transfer lipid fundament smp domain lipid transport requir regul c domain mediat membran tether addit e syt tcb ca modul ltps sens interact ca c domain chapter describ vitro reconstitut biochem assay studi function mechan e syt express purifi recombin protein prepar reconstitut system develop assay membran tether lipid transport | D004721;D024101 | T026;T123;T116 |
36,220,275 | gel electrophoresi base assay measur enzymat rna decap activ rna end remark heterogen addit eukaryot methyl guanosin mg cap number primarili metabolit base cap structur identifi prokaryot eukaryot system metabolit cap includ nicotinamid adenin dinucleotid nad nadh dephosphocoenzym dpcoa flavin adenin dinucleotid fad dinucleotid polyphosph uridin diphosph n acetylglucosamin udp glcnac chen et al kowtoniuk et al wang et al high studi new cap structur nad signific effect rna stabil bird et al jiao et al prokaryot eukaryot decap enzym specif metabolit cap decap integr step control rna stabil cahov et al jiao et al sharma et al zhang et al better studi metabolit rnas decap present method generat radiolabel dinucleotid full length cap rna substrat use decap assay simpl decap assay test activ various enzym differ cap transcript gel electrophoresi base method visual differenti cap transcript | D009243;D012315 | T121;T123;T114 |
36,220,274 | biophys structur character effect mutat structur activ relationship sar cov spike protein mutat spike protein sar cov could induc structur chang help increas viral transmiss enhanc resist antibodi neutral report robust workflow prepar recombin protein variant host receptor angiotensin convert enzym ace use mammalian cell express system function state protein variant investig cryo electron microscopi cryo em negat stain electron microscopi nsem visual molecular structur respons mutat receptor bind antibodi bind environment chang fold stabil protein variant deduc morpholog chang base nsem imag analysi differenti scan calorimetri provid thermodynam inform complement nsem impact mutat host receptor bind antibodi neutral vitro kinet bind analys addit atom insight glean cryo electron microscopi cryo em experiment strategi general applic studi molecular basi host pathogen interact | D000086382;D064370 | T116;T047;T123;T067 |
36,220,273 | elucid fold pathway knot protein understand mechan protein fold thread topolog knot conform challeng appar complex associ fold thread event nevertheless mani experiment comput studi provid insight fold pathway knot protein show knot protein could spontan revers fold knot topolog high popul intermedi time multipl fold pathway laboratori report fold mechan varieti knot protein differ knot type rang simplest trefoil knot complex stevedor knot therefor focus use multiplex thermodynam kinet measur teas uniqu inform associ differ structur probe obtain comprehens overview fold mechan knot protein interest chapter shall discuss use differ biophys tool analyt model glean mechanist insight intric polypeptid attain knot topolog | D017510;D011506 | T044;T123;T116 |
36,220,272 | phosphoryl subcellular local human phospholipas ddhdpa pla protein phosphoryl common post translat modif protein function molecular switch regul modif revers regul protein kinas phosphatas case phosphoryl enzym posit negat regul enzym activ howev found phosphoryl ddhd phospholipas pla affect pla activ integr analys includ phospho proteom phos tag sds page pla enzym assay immunofluoresc microscopi reveal subcellular local ddhd without great affect pla activ find may contribut understand rare clinic case concern implic protein phosphoryl | D010744;D011494 | T126;T116 |
36,220,271 | fluorogen rna aptam probe transcript initi co transcript rna fold multi subunit rna polymeras transcript first high regul step gene express experiment techniqu monitor transcript thus import studi gene express gene regul well translat research drug develop fluoresc method often superior techniqu real time monitor biochem process green fluoresc protein long serv valuabl tool studi process translat present two method util fluoresc light rna aptam flap rna mimic green fluoresc protein monitor transcript co transcript rna fold flap adopt defin three dimension fold bind low molecular weight compound call fluorogen concomit increas fluoresc mani fold flap provid strong fluoresc signal low background allow monitor transcript real time vitro vivo howev take sever second rna polymeras synthes flap subsequ fold fluorogen bind platform take addit second minut show broccoli flap well suit monitor rate transcript initi multi round setup mitig slow rate flap matur furthermor demonstr relat slow ineffici fold ispinach flap taken advantag monitor action rna fold chaperon | D052157 | T114 |
36,220,270 | cellular experi studi inhibit c mycmax heterodimer c myc oncogen master regul cancer cell metabol control varieti pathway includ cell prolifer cell cycl apoptosi epigenet belong bhlh famili transcript factor c myc form heterodimer complex anoth bhlh famili protein max c myc deregul report cancer heterodimer complex potent transcript factor control express target gene bind e box sequenc therebi control cancer cell prolifer c myc isol partial fold structur carri transcript howev heterodimer provid abil bind dna carri regulatori function therefor heterodimer c myc max great interest cancer alway consid target cancer therapi book chapter present detail protocol cellular experi employ valid vitro potenc c myc inhibitor candid search novel c myc target neoplast drug | D016271;D014157 | T123;T116 |
36,220,269 | isol synchron e coli elong complex solid phase solut base vitro transcript assay synchron transcript elong complex tec fundament tool investig biochem properti rna polymeras rnap nascent rna recent develop standard system isol high puriti synchron e coli rnap tec vitro transcript reaction system use custom leader sequenc call c sc immobil synchron tec magnet bead free dna non product transcript complex deplet synchron elong complex isol procedur call c sc tec activ pure use solid phase solut base transcript assay yield procedur relat input dna c sc tec isol solid phase assay c sc tec isol solut base assay describ protocol purifi c sc tec assess activ homogen yield c sc tec prepar | D004926;D014158 | T007;T045 |
36,220,268 | purif biochem character rag gtpase heterodim mechanist target rapamycin complex mtorc sens nutrient level cell base avail regul cellular growth prolifer activ tight modul two gtpase unit rag gtpase rheb gtpase rag gtpase central hub amino acid sens summar amino acid signal upstream regul control subcellular local mtorc uniqu canon signal gtpase rag gtpase obligatori heterodim two subunit coordin nucleotid load state regul function state robust biochem analysi indispens understand molecular mechan govern gtpase cycl chapter discuss protocol purifi biochem character rag gtpase heterodim describ two purif protocol recombin produc rag gtpase heterodim larg quantiti describ assay quantit measur nucleotid bind hydrolysi rag gtpase assay allow thorough investig uniqu heterodimer gtpase could applic investig noncanon gtpase | D020559 | T126;T116 |
36,220,267 | rapid method sub compartment identif protein interactom protein protein interact central cellular process dysregul relat develop various diseas proxim base label method use identifi endogen interact partner specif protein interest poi poi fuse promiscu enzym generat reactiv speci vivo label protein close vicin apex base proxim label techniqu util engin ascorb peroxidas presenc h oxid biotin phenol short live biotin phenoxyl radic biotinyl nearbi protein biotinyl protein enrich biotin affin captur identifi mass spectrometri devis advanc method rapid peroxidas physic separ poi rapamycin induc dimer use frb fkbp system bring two protein togeth rapid improv specif apex base interactom analysi strict elimin fals posit chapter describ method detail vapb protein interest version apex differ subcellular local vapb local differ cellular compart endoplasm reticulum inner nuclear membran yield distinct set proxim partner identifi rapid | D001710;D006861 | T121;T109;T127;T130;T197 |
36,220,266 | engin protein dna tool creat dna depend protein switch switchabl protein capabl chang conform inact activ form respons input ligand bind ph temperatur chang light absorpt particular power class protein switch exemplifi cas nucleas crispr system activ bind specif dna rna sequenc mechan oligonucleotid bind regul biolog activ complex high special case cas enzym recent advanc protein dna engin made possibl introduc mode control enzym chapter highlight recent exampl protein switch combin two field engin purpos creat biosensor detect pathogen genom sequenc one protein engin method altern frame fold potenti convert mani protein ligand activ switch insert bind protein input domain enzym output domain step illustr use gcn dna recognit domain nanoluciferas luminesc report chang color result dna bind dna engin protocol includ creat dna tool de novo design hairpin modifi aptam enabl biosensor activ arbitrari dnarna sequenc small moleculesprotein respect methodolog appli protein gain control function dna bind | D015202;D011506 | T116;T123;T063 |
36,220,261 | flexor tendon lacer hand open glass ampoul sharp needlestick injuri serious work relat injuri hand healthcar worker hcws present two case hcws hand injuri open medicin glass ampoul index finger involv case associ flexor tendon injuri present inabl flex proxim distal interphalang joint sensat intact radiograph show foreign bodyth surgic repair flexor tendon injuri carri use wide awak local anaesthesia tourniquet techniqu qualiti repair test intraop physiotherapi involv gradual progress finger flexion full rang motion month follow regain rang motion return workflexor tendon injuri open medicin glass ampoul rare devast long rehabilit process surgic repair | D005383;D022125;D013708 | T037 |
36,220,260 | cytomegalovir coliti primari cmv viraemia young immunocompet adult man present week histori fever fatigu diarrhoea arriv emerg depart clinic find sepsi care team initi suspect sepsi secondari bacteri coliti administ antibiot workup includ stool pcr assay gastrointestin pathogen fail establish diagnosi evid immun compromis colonoscopi reveal mucos ulcer presum ulcer coliti histopatholog obtain discharg reveal sever coliti cytomegalovirus cmv inclus serolog studi indic primari cmv infect knowledg first report primari cmv infect present sever coliti system diseas young immunocompet patient without under diseas | D003092;D003093;D003586;D004760;D059413;D009894 | T047 |
36,220,198 | baselin characterist particip pre diabet intervent continu track eas diabet pre dict program pre diabet intervent continu track eas diabet pre dict program diabet prevent trial compar diabet convers rate year intervent group receiv incentiv lifestyl intervent program stepwis addit metformin control group receiv standard care describ baselin characterist compar pre dict particip diabet prevent trial cohort | D003920;D018149;D008687;D011236 | T121;T047;T109 |
36,220,197 | effect progress resist train weight loss compar weight loss alon fatti liver index older adult type diabet secondari analysi month random control trial non alcohol fatti liver diseas nafld high preval peopl type diabet td sinc exercis weight loss wl recommend manag nafld td studi examin whether progress resist train prt plus wl could lead greater improv fatti liver index fli indic nafld compar wl alon older adult td | D003924;D065626;D055070 | T061;T047 |
36,220,196 | insulin resist base postglucos load measur associ preval burden cerebr small vessel diseas cerebr small vessel diseas csvd high preval result irrevers cognit impair reduc qualiti life previous studi report controversi associ insulin resist csvd estim associ insulin resist csvd non diabet communiti southeastern china | D059345;D007333 | T047;T046 |
36,220,195 | use oral diabet medic risk incid dementia us veteran age year type diabet studi report antidiabet medic adm associ lower risk dementia current find inconsist studi compar risk dementia onset patient type diabet td treat sulfonylurea su thiazolidinedion tzd patient td treat metformin met | D003924;D008687;D045162;D014728 | T121;T047;T109;T098 |
36,220,188 | type ifn signal protect mice lethal sar cov neuroinvas multipl organ damag common patient sever covid even though under pathogen mechan remain unclear acut viral infect typic activ type ifn ifn signal antivir role ifn well character vitro howev understand ifn regul host immun respons sar cov infect vivo incomplet use human ace transgen mous model show present studi ifn receptor signal essenti protect acut lethal sar cov mice interest although ifn signal limit viral replic lung primari infect site dispens effici viral clearanc adapt phase sar cov infect convers found absenc ifn receptor signal extrem anim lethal consist heighten infecti virus promin patholog manifest brain taken togeth result studi demonstr ifn receptor signal requir restrict virus neuroinvas therebi mitig covid sever | D000086382;D000086402 | T047;T067;T005 |
36,220,187 | influenza induc cd resid memori cell exhibit enhanc function avid cd memori cell mediastin lymph node influenza virus specif tissu resid memori cd cell trms target conserv viral protein provid strain transcend heterosubtyp immun infect trms lung combat reinfect rapid cytolyt function product inflammatori cytokin recruit immun cell influenza specif trms also generat lung drain mediastin lymph node mln provid immun heterolog virus infect tissu although role combat influenza infect less well defin function avid measur cell sensit ag stimul correl control viral infect may import immun detect recent infect cell low number surfac peptid mhc complex display howev function avid influenza specif trms previous compar memori cd cell subset articl methodolog present compar function avid cd cell subset across murin tissu focus influenza specif mlns compar splenic cd cell stimul popul well account cd cell extrins variabl function avid influenza specif mln effector cd cell slight increas relat splenic effector cd cell howev cd mln trms display increas function avid compar splenic memori cd cell cd memori cd cell within mln contrast lung deriv cd trms exhibit enhanc function avid mln cd trms also exhibit increas tcr express provid potenti mechan enhanc function avid | D007251 | T047 |
36,220,186 | hiv specif car cell cd bb signal domain phenotyp function distinct effect suppress hiv simian immunodefici virus despit mount robust antivir cd cell respons hiv infect infect individu unabl control hiv viral load without antiretrovir therapi art chimer ag receptor car cell treatment intens investig altern therapi art free remiss chronic hiv infect howev achiev durabl remiss hiv requir success balanc car cell effector function persist car cell cd costimulatori domain robust effector function limit persist vivo wherea car cell bb costimulatori domain present undifferenti phenotyp greater vivo persist compar vitro phenotyp function rhesus macaqu human car cell contain either cd bb costimulatori domain construct also includ car bispecif gp hiv siv cxcr moieti promot vivo home carcxcr cell b cell follicl cell transduc use gammaretrovir vector evalu use flow cytometri bb carcxcr cell phenotyp distinct cd carcxcr cell show increas express car cd import cd bb carcxcr cell retain equal capac recogn suppress siv vitro studi provid new insight rhesus macaqu human bb cd bear car cell | D015658;D000076962;D015302 | T047;T116;T192;T129;T005 |
36,220,182 | variat low valu radiograph use children emerg depart cross section studi administr databas radiograph use contribut low valu care children emerg depart ed littl known system factor associ use studi compar low valu radiograph use across ed set hospit type pediatr volum physician specialti | D001249;D001988 | T047 |
36,220,181 | use link data assess impact includ hospit death day hospit mortal indic retrospect cohort studi canadian institut health inform cihi annual report health system perform indic includ various day hospit mortal rate aim assess impact includ hospit death cihi indic day acut myocardi infarct ami hospit mortal day stroke hospit mortal hospit death follow major surgeri | D009203;D020521 | T047 |
36,220,174 | vaccin effect primari seri booster dose covid associ hospit admiss unit state live test negat design studi compar effect primari covid vaccin seri plus booster dose primari seri alon prevent hospit admiss omicron relat covid unit state | D000086382;D000086663 | T047;T200;T067 |
36,220,151 | use anatom radiograph horizon later center edg angl classif hip dysplasia later center edg angl wiberg lcea tnnis angl ta reli horizon function refer point measur hip dysplasia weightbear anteroposterior pelvi radiograph differ horizon current util depend surgeon prefer line parallel radiograph floor f line connect inferior portion acetabular teardrop at line connect ischial tuberos imper accur assess degre hip dysplasia initi workup select appropri surgic intervent | D006617;D006618 | T047;T190;T019;T037 |
36,220,146 | phycolog explor global biodivers hotspot northeast india discoveri new speci soil dwell cyanobacteria desikacharya kailashaharensi sp nov soil dwell cyanobacteri strain kls bp ap isol biodivers rich northeast region india character use polyphas approach strain collect field cover grass near stream unakoti district tripura upon cultur laboratori initi studi indic strain show typic nostoc nostoc like morpholog subsequ rrna gene phylogenet analys use neighbour join maximum likelihood bayesian infer method gave distinct stabl posit strain insid genus desikacharya upon recoveri full length operon region trnas trnail trnaala fold secondari structur reveal uniqu pattern v box b v region strain kls bp ap compar phylogenet relat speci genus desikacharya total evid approach indic conclus strain investig new speci genus desikacharya describ desikacharya kailashaharensi accord intern code nomenclatur alga fungi plant rrna gene phylogeni evalu operon along impli examin famili level affili desikacharya well generic limit may order notabl studi bring focus less explor northeast region india share two global biodivers hotspot world | D012987;D046937 | T007;T167 |
36,220,137 | recent chang incid thyroid cancer korea analysi korean nation data studi evalu recent chang standard age specif stage specif incid rate ir thyroid cancer korea compar incid data report surveil epidemiolog end result program | D013964 | T191 |
36,220,135 | effect covid pandem invas pneumococc diseas children catalonia spain analyz effect covid healthcar demand invas pneumococc diseas children catalonia spain compar note larg reduct healthcar activ incid invas pneumococc diseas chang like result nonpharmaceut measur implement covid pandem | D000086382;D011008 | T047;T067 |
36,220,131 | coronavirus antibodi respons covid pandem africa thailand prior immun respons coronavirus might affect human sar cov respons screen serum plasma sampl collect earli covid pandem began person countri africa kenya nigeria tanzania uganda thailand includ person live hiv detect igg respons sar cov spike subunit protein particip profil coronavirus antigen reveal respons subunit subunit protein signific frequent respons receptor bind domain trimer nucleocapsid protein p observ similar respons person without hiv among coronavirus antigen test sar cov sar cov middl east respiratori syndrom coronavirus antibodi respons much higher particip africa particip thailand p note less pronounc differ endem coronavirus serosurvey could affect vaccin monoclon antibodi distribut across global popul | D000086382 | T047;T067 |
36,220,130 | socioeconom inequ covid vaccin infect adult catalonia spain evid impact covid vaccin rollout socioeconom covid relat inequ scarc analyz associ socioeconom depriv index sdi covid vaccin infect hospit vaccin rollout catalonia spain conduct popul base cohort studi septemb june compris adult year age estim odd ratio nonvaccin hazard ratio hrs infect hospit sdi quintil relat least depriv quintil q six month rollout vaccin coverag differ sdi quintil work age year person q q rollout found pattern increas hr infect hospit depriv among work age retir age year person rollout infect inequ decreas age group wherea hospit inequ decreas among retir age person find suggest mass vaccin reduc socioeconom covid relat inequ | D000086663;D000086382 | T067;T047;T200 |
36,220,127 | secondari headach disord approach workup special consider select popul headach one common diagnos neurolog thorough understand clinic present secondari headach life threaten critic review provid overview diagnost approach patient headach includ discuss red orang green flag emphas particular scenario help tailor clinic workup individu circumst pregnant women particular attent must paid effect blood pressur hypercoagul well older adult need higher suspicion intracrani mass lesion giant cell arter patient risk factor headach secondari alter intracrani pressur whether elev eg idiopath intracrani hypertens decreas eg cerebrospin fluid leak may requir specif diagnost test treatment final headach patient covid long covid increas recogn may multipl etiolog | D000086382;D051271;D011559;D011251 | T047;T067 |
36,220,111 | autom cognit health assess use partial complet time seri sensor data behavior health inextric link result continu wearabl sensor data offer potenti predict clinic measur howev interrupt data collect occur creat need strateg data imput | D000069550;D000465 | T170;T066 |
36,220,110 | explain knowledg base system use subject prefer object data rank decis altern allergi hypersensit reaction occur allergen react immun system preval sever allergi upris south asian countri allergi often occur combin becom difficult physician diagnos | D010820;D006967 | T046;T097 |
36,220,108 | elicit inform need child patient adapt kano model design mhealth applic health care servic increas digit extant literatur show digit technolog applic often develop without care consider user need research need identifi investig best class method support user center design mhealth applic | D017216 | T058 |
36,220,102 | nuclear mrna metabol drive select basket assembl subset nuclear pore complex bud yeast determin transcript reach cytoplasm translat eukaryot cell establish mechan regul select mrna export nuclear pore complex npc nuclear basket substructur npc protrud nucleoplasm thought function stabl platform mrna protein complex mrnps rearrang undergo qualiti control prior export ensur matur mrnas reach cytoplasm use proteom genet live cell singl molecul resolut microscopi approach bud yeast demonstr basket format depend rna polymeras ii transcript subsequ mrnp process show npcs bind mlp basket assembl subset nucleoplasm npcs basket contain npcs associ distinct protein rna interactom taken togeth data point toward npc heterogen rna depend mechan function npcs bud yeast nuclear basket assembl | D022022;D004718 | T026;T004 |
36,220,101 | structur insight rna mediat transcript regul bacteria rna regul synthesi without auxiliari protein exampl u rich rna sequenc signal rna polymeras rnap paus transcript requir transcript releas intrins termin kingdom life contrast regulatori rna putl suppress paus termin cis howev nascent rna modul synthesi remain larg unknown present cryo em reconstruct rnap captur transcript putl variant unrel sequenc u rich paus site result suggest putl suppress paus promot synthesi demonstr transcrib u rich sequenc ubiquit trigger intrins termin promot widen rnap nucleic acid bind channel widen destabil rnap interact dna rna facilit transcript dissoci reminisc intrins transcript termin surpris rnap remain bound dna transcript releas result provid structur framework understand rna mediat intrins transcript termin | D012313;D012321 | T126;T116;T114 |
36,220,095 | coral physiolog go ciliari flow coral long known generat local fluid flow use ciliari beat import ciliari flow discov two new paper shed light ciliari flow physic play key role shape coral physiolog | D037421 | T204 |
36,220,094 | microtubul sever enzym stephani sarban et al discuss microtubul sever enzym highlight share structur mechan divers process particip | D008870 | T026 |
36,220,091 | sensori integr time temperatur regul fli siesta temperatur outsid prefer rang requir fli acut adjust behavior new studi find heat sens neuron provid input fli circadian clock neuron extend daytim siesta allow fli sleep excess daytim heat | D057906;D029721 | T116;T123;T040 |
36,220,090 | symbiosi partner crime defens symbiont protect host immin threat new studi uncov symbiosi wherebi fungus safeguard beetl host predat also exploit beetl vector help attack plant caus diseas | D001517;D013559 | T070;T040;T204 |
36,220,089 | pollin cognit frame bee memori ecolog context bee memori well character laboratori experi relev forag ecolog context less well studi new studi show short term memori bumbl bee correl springtim forag effici floral resourc abund summer forag effici resourc scarc | D003071;D035264 | T041;T002 |
36,220,088 | visual cortex big data analysi uncov food specif visual cortex anatom distinct patch respond distinct categori face text new research confirm parcel use unsupervis analysi function magnet reson imag data obtain human view ten thousand imag discov one prefer food | D001931;D014793 | T023;T062;T060;T029 |
36,220,087 | evolut evolutionari rat race new guinea australia new molecular phylogeni remark radiat new guinean australian rodent indic multipl transit biom biogeograph region within group suggest key role play geolog histori new guinea | D005075;D017753 | T082;T045;T070 |
36,220,086 | worm develop push pull gonad morphogenesi tissu elong occur recent paper identifi new mechan elong caenorhabd elegan hermaphrodit gonad driven pressur prolifer germ cell confin within tube distal tip cell cap tube remodel extracellular matrix adjust cell matrix adhes guid way | D017173;D029742 | T116;T204 |
36,220,085 | evolut biochemistri honest sexual signal discoveri new enzym requir product red carotenoid pigment vertebr provid insight share biochem pathway may key understand honest signal via plumag color | D005241;D010858 | T023;T032 |
36,220,084 | sensori biolog olfactori crosstalk reshap odor code new research uncov novel form crosstalk olfactori pathway antenn lobe first olfactori center fli brain crosstalk reshap odor code may explain carbon dioxid elicit either attract avers | D009812;D018034 | T026;T025;T120;T070 |
36,220,083 | plant physiolog anatomi plant action potenti venus flytrap possess modifi leav snap shut fast enough catch fli new studi identifi major compon toolkit allow flytrap fire action potenti illustr differ ion channel transport recruit give rise uniqu plant behaviour respons | D031257 | T002 |
36,220,082 | competit endotheli cell polar drive vascular morphogenesi mous retina blood vessel format generat uniqu vascular pattern individu principl govern appar stochast process remain elucid use mathemat method find transit two fundament vascular morphogenet program sprout angiogenesi vascular remodel establish shift collect front rear polar endotheli cell mous retina demonstr competit biochem vegfa mechan blood flow induc shear stress cue control collect polar shift shear stress increas tension focal adhes overrid vegfa driven collect polar reli tension adheren junction propos vascular morphogenet cue compet regul individu cell polar migrat tension shift translat tissu level emerg behavior ultim lead uniqu organ vascular pattern | D016764;D042783 | T025;T082 |
36,220,081 | kifb promot pik signal gradient caus chang shh protein gradient suppress polydactyli mice digit determin limb bud driven posterior sonic hedgehog shh protein gradient howev mechan regul unclear propos diffus trap hypothesi shh gradient format base data preaxial polydactyli phenotyp kifb motor hypomorph mice limb bud mice distal proxim gradient fibroblast growth factor fgf phosphatidylinositol kinas pik signal posterior anterior gradient shh disorgan phenotyp reproduc transplant fgfb soak bead subcellular level kifb transport phosphatas tensin homolog pten like phosphatas talpid termin pik signal high low pik signal strength differenti sort endocytos shh toward exosom like particl cytonem punctata respect result indic shh contain particl undergo either diffusion movement peripheri cytonem trap center form spatial gradient along peripheri develop limb bud | D053823;D017689 | T019;T123;T116 |
36,220,080 | fold make differ coolair mediat regul plant flower time secondari structur rna molecul affect regul function whether transcript isoform adopt specif arrang affect function unclear recent issu natur yang et al reveal non code rna coolair adopt isoform specif secondari structur differenti regul flower | D017360;D029681 | T116;T002 |
36,220,079 | build kidney tree function collect duct human pluripot stem cell human development studi regen therapi need vitro system generat cell type recapitul matur cell physiolog recent issu natur biotechnolog shi et al show pluripot stem cell differenti ureter bud organoid matur function kidney collect duct cell type | D007668;D039904 | T023;T025 |
36,220,078 | neural crest cell hijack pluripot stem cell factor realiz development potenti neural crest cell aris neurectoderm vertebr embryo development potenti goe way beyond neurectoderm deriv issu development cell hovland et al reveal neural crest cell employ embryon stem cell factor combin specif transcript factor enabl broad potenti | D009432;D039904 | T018;T025 |
36,220,074 | tumor microbiom link cellular program immun pancreat cancer microorgan detect multipl cancer type includ putat steril organ context influenc oncogenesi anti tumor respons human remain unclear recent develop singl cell analysi host microbiom interact sahmi comput pipelin recov denois microbi signal singl cell sequenc host tissu use sahmi interrog tumor microbiom interact two human pancreat cancer cohort identifi somat cell associ bacteria subset tumor near absenc nonmalign tissu bacteria predomin pair tumor cell presenc associ cell type specif gene express pathway activ includ cell motil immun signal model result indic tumor infiltr lymphocyt close resembl cell infect tissu final use multipl independ dataset signatur cell associ bacteria predict clinic prognosi tumor microbiom crosstalk may modul tumorigenesi pancreat cancer implic clinic manag | D064307;D010190 | T191;T001;T032;T028 |
36,220,073 | peroxynitrit tumor microenviron chang profil antigen allow escap cancer immunotherapi cancer immunotherapi often depend recognit peptid epitop cytotox lymphocyt ctls tumor microenviron tme enrich peroxynitrit pnt potent oxid produc infiltr myeloid cell tumor cell demonstr pnt alter profil mhc class bound peptid present tumor cell ctls specif pnt resist peptid strong antitumor effect vivo wherea ctls specif pnt sensit peptid effect therapeut target pnt mice reduc resist tumor cell ctls melanoma patient low pnt activ tumor demonstr better clinic respons immunotherapi patient high pnt activ data suggest intratumor pnt activ consid design neoantigen base therapi also may import immunotherapeut target | D008545;D059016 | T191;T070 |
36,220,072 | artifici intellig multimod data integr oncolog oncolog patient state character whole spectrum modal rang radiolog histolog genom electron health record current artifici intellig ai model oper main realm singl modal neglect broader clinic context inevit diminish potenti integr differ data modal provid opportun increas robust accuraci diagnost prognost model bring ai closer clinic practic ai model also capabl discov novel pattern within across modal suitabl explain differ patient outcom treatment resist insight glean model guid explor studi contribut discoveri novel biomark therapeut target support advanc present synopsi ai method strategi multimod data fusion associ discoveri outlin approach ai interpret direct ai driven explor multimod data interconnect examin challeng clinic adopt discuss emerg solut | D001185;D011871 | T090;T091;T066;T073 |
36,220,071 | cold exposur anti cancer therapi seki et al report natur increas glucos catabol brown adipos tissu cold exposur lower blood glucos insulin toler system effect bodi metabol decreas glucos catabol tumor arrest tumor progress offer novel altern approach metabol base cancer therapi | D001786;D061385 | T121;T109 |
36,220,070 | sting oper expos kras stk co mutat lung cancer kras stk lkb co mutat kl tumor defin immunolog cold anti pd l refractori non small cell lung cancer nsclc subset issu cancer cell kitajima et al outlin strategi unleash innat immun kl tumor util epigenet de repress sting puls inhibit spindl assembl checkpoint kinas mps | D002289;D008175 | T191 |
36,220,069 | time restrict eat without low carbohydr diet reduc viscer fat improv metabol syndrom random trial overconsumpt carbohydr rich food combin advers eat pattern contribut increas incid metabol syndrom met china therefor conduct random trial determin effect low carbohydr diet lcd h time restrict eat tre schedul combin bodi weight abdomin fat area ie primari outcom cardiometabol outcom particip met compar baselin month treatment signific reduc bodi weight subcutan fat area tre combin treatment reduc viscer fat area vfa fast blood glucos uric acid ua dyslipidemia furthermor compar chang lcd tre combin treatment decreas bodi weight vfa combin treatment yield benefit glycem control ua dyslipidemia conclus without chang physic activ h tre without lcd serv effect treatment met clinicaltrialsgov nct | D024821;D050171 | T047;T046 |
36,220,068 | singl cell spatial transcriptom reveal dynam control metabol zonat liver regener endotheli cell wnt wntb conclus ident wnts regul liver zonat lz regener lr remain unclear despit undisput role catenin use singl cell analysi identifi conserv wnt wntb express endotheli cell ec zone ec elimin wnt wntb led loss catenin target zone appear zone gene zone unravel dynam lz process impair lr observ knockout phenocopi model defect hepat wnt signal administr tetraval antibodi activ wnt signal rescu lz lr knockout induc zone gene express lr control administr agonist also promot lr acetaminophen overdos acut liver failur alf fulfil unmet clinic need overal report unequivoc role ec wnt wntb lz lr show role wnt activ regen therapi alf | D008115;D020518 | T047;T042 |
36,220,067 | leptin increas hepat triglycerid export via vagal mechan human recombin human leptin metreleptin reduc hepat lipid content patient lipodystrophi overweight patient non alcohol fatti liver diseas relat hypoleptinemia independ anorex action rodent leptin signal brain increas low densiti lipoprotein triglycerid vldl tg secret reduc hepat lipid content via vagus nerv random placebo control crossov trial eudract nr test whether compar mechan regul hepat lipid metabol human singl metreleptin inject stimul hepat vldl tg secret primari outcom reduc hepat lipid content fast lean men n age rang year fail metabol healthi liver transplant recipi n age rang year repres model hepat denerv independ cohort lean men n age rang year vagal stimul modifi sham feed replic effect metreleptin vldl tg secret therefor propos leptin anti steatot properti independ food intak stimul hepat vldl tg export via brain vagus liver axi | D020738;D065626 | T047;T116;T125 |
36,220,066 | mix realiti vascular surgeri scope review mix realiti mr allow project virtual object user field view head mount display hmd intervent surgic treatment vascular diseas mr applic could futur benefit follow scope review aim provid orient current applic aforement technolog field vascular surgeri defin research goal futur | D025321 | T061 |
36,220,065 | status inner branch complex endovascular aortic repair complex endovascular therapi aorta fenestr branch endograft play essenti role modern vascular medicin innov solut demand aortic patholog therefor constant develop medic industri aim manuscript illustr grow import inner branch complex aortic repair show advantag limit techniqu overview current literatur inner branch ibevar therefor compar standard treatment option fenestr fevar outer branch bevar technic advantag platform evalu widespread use ibevar aortic arch stand contrast thoracoabdomin aorta mirror scarc evid thoracoabdomin inner branch publish experi base smaller retrospect studi year follow e nside artivion hechingen germani thoracoabdomin shelf inner branch base endograft releas year ago widespread deploy may increas use inner branch thoracoabdomin aorta moreov ongo industri fund registri may provid new insight long term durabl innov techniqu | D017544;D017545;D019917;D057510 | T061;T047 |
36,220,059 | structur inequ medicin contribut racial inequ asthma care structur inequ medicin present centuri unit state recent recogn contributor racial inequ asthma care asthma outcom chapter provid systemat review structur factor racial bias spirometri algorithm histori system racism medicin workforcepipelin limit presenc underrepres minor health care provid bias research fund award strategi solv problem | D001249;D063505 | T054;T047 |
36,220,058 | phenotyp precis medicin asthma tradit one size fit approach base asthma sever archaic asthma heterogen syndrom rather singl diseas entiti studi evalu observ characterist call phenotyp elucid heterogen asthma cluster demonstr overlap featur general stabl time reproduc identif cluster may fail move needl precis medicin meaning asthma may relat lack straightforward clinic meaning way appli learn asthma cluster cluster base clinic factor biomark use biomark slowli gain popular phenotyp base biomark general great underutil even subspecialti care biomark often use evalu type inflammatori signatur eosinophil sputum blood fraction exhal nitric oxid feno serum total specif immunoglobulin ig e reliabl character under inflammatori pathway biomark perform variabl clinician must familiar advantag disadvantag accur appli clinic care addit increas clear clinic featur critic understand phenotyp character predict respons therapi futur risk poor outcom strategi asthma manag need leverag knowledg biomark clinic featur creat composit score risk predict tool clinic applic despit signific progress mani question remain work requir accur identifi non biomark adopt phenotyp consist use biomark need continu encourag incorpor practic | D001249;D057285 | T061;T047;T091 |
36,220,057 | racial inequ asthma care racial inequ asthma care evolv recogn factor long stand inequ asthma outcom eg hospit mortal littl research conduct regard presenc absenc racial inequ among patient seen asthma specialist set import area futur research given asthma specialist care recommend patient experienc poor asthma outcom disproportion experienc black hispan patient studi provid systemat review racial asthma care inequ asthma epidemiolog clinic assess medic prescript asthma specialist referr practic | D001249 | T047 |
36,220,056 | current biolog asthma treatment uncontrol asthma andor sever asthma caus signific impair qualiti life often huge health care burden monoclon antibodi import addit therapeut manag patient moder sever asthma respond convent asthma manag current major food drug administr fda approv biolog target high inflamm howev expand knowledg asthma pathogenesi novel therapeut target low inflamm develop articl focus current understand inflamm approv biolog moder sever asthma | D018927;D001249;D001688 | T121;T047;T123 |
36,220,055 | assess bubbl activ generat histotripsi combin echogen liposom objectivehistotripsi form focus ultrasound therapi use mechan activ bubbl ablat tissu histotripsi alon degrad cellular content tissu recent studi demonstr effect disrupt extracellular structur patholog condit venous thrombosi combin thrombolyt drug rather reli standard administr method associ thrombolyt drug ultrasound trigger echogen liposom vesicl enabl target system drug deliveri date histotripsi primarili reli nano nuclei inher medium bubbl cloud generat microbubbl associ echogen liposom may alter histotripsi bubbl dynam object work investig interact histotripsi puls echogen liposomesapproachbubbl cloud generat use focus sourc anin vitromodel venous flow acoust emiss generat inson passiv acquir assess mechan activ bubbl cloud high frame rate puls invers imag use track chang echogen liposom follow histotripsi exposuremain resultsfor peak negat pressur less mpa acoust emiss indic stabl inerti bubbl activ observ peak negat pressur histotripsi excit increas harmon excit observ ofp elip solut plasma alon addit observ high frame rate imag indic transit bubbl behavior puls pressur transit shock wave formationsignificancethes observ suggest complex interact histotripsi puls echogen liposom may exploit combin treatment approach | D008081;D057086 | T061;T109 |
36,220,053 | assess incid power densiti differ shape averag area radio frequenc exposur ghz objectiveth intern commiss non ioniz radiat protect guidelin ieee c standard human protect local electromagnet field exposur ghz state absorb epitheli power densiti apd incid power densiti ipd averag squar area intern extern physic quantiti respect set exposur limit per exposur standard measur procedur evalu ipd establish technic standard circular averag area recommend non planar surfac ieciee studi effect two averag shape apd ipd evalu comput provid new insight viewpoint exposur standardsapproach relat apd ipd steadi state temperatur rise heat factor rectangular human model exposur singl dipol dipol array gaussian beam investig comput finit differ methodmain result maximum differ heat factor apd ipd squar circular averag area antenna model distanc gt mm respect differ appear beam pattern model surfac ellipt shape antenna model distanc mm frequenc ghz heat factor squar averag area alway conserv circular one ipd antenna feed point visibl beam formationsignific heat factor apd ipd circular averag area conserv near field exposur canon sourc frequenc ghz except beam signific major minor axi ratio angl squar averag area tendenc would help bridg gap exposur product standard | D011846;D004574 | T070 |
36,220,015 | clinic relev onlin patient qa solut daili ct scan epid basedin vivodosimetri feasibl studi rectal cancer objectiveadapt radiat therapi art could protect organ risk oar maintain high dose coverag target howev still lack effici onlin patient qualiti assur qa method obstacl larg scale adopt art aim develop clinic relev onlin patient qa solut art use daili ct scan epid basedin vivodosimetryapproachten patient rectal cancer center includ patient daili ct scan portal imag collect generat reconstruct dose distribut contour target oar recontour daili ct scan clinician auto segment algorithm dose volum indic calcul percent deviat indic origin plan determin deviat regard metric clinic relev patient qa toler level obtain use confid interv qa metric distribut deviat could divid anatom relev deliveri relev indic error sourc analysi final qa solut valid addit six clinic patientsmain resultsin rectal cancer confid interv qa metric ptv ptv valid ptv ptv fraction within toler qa metric one patient dosimetr impact anatom variat treatment observ sourc error analysissignificanceth onlin patient qa solut use daili ct scan epid basedin vivodosimetri clinic feasibl sourc error analysi potenti distinguish sourc error guid art futur treatment | D050397;D012004 | T191;T061 |
36,220,014 | cross modal fusion modal specif lung tumor segment pet ct imag although positron emiss tomographi comput tomographi pet ct imag wide use still challeng accur segment lung tumor respir movement imag modal lead larg modal discrep lung tumor pet imag ct imag overcom difficulti novel network design simultan obtain correspond lung tumor pet imag ct imag propos network fuse complementari inform preserv modal specif featur pet imag ct imag due complementar pet imag ct imag two modal imag fuse automat lung tumor segment therefor cross modal decod block design extract modal specif featur pet imag ct imag constraint modal edg consist loss also design solv problem blur boundari pet imag ct imag propos method test pet ct imag non small cell lung cancer dice similar coeffici score lung tumor segment reach ct imag pet imag respect extens comparison state art lung tumor segment method also perform demonstr superior propos network | D008175;D002289 | T191 |
36,220,011 | abpo tvscad altern bregman proxim oper approach base tvscad regular bioluminesc tomographi object bioluminesc tomographi blt promis non invas optic medic imag techniqu visual quantit analyz distribut tumor cell live tissu howev due influenc photon scatter effect ill condit invers problem reconstruct result unsatisfactori purpos studi improv reconstruct perform blt approach altern bregman proxim oper abpo method base tvscad regular propos blt reconstruct tvscad combin anisotrop total variat tv regular constraint non convex smooth clip absolut deviat scad penalti constraint make trade sparsiti edg preserv sourc abpo approach use solv tvscad model abpo tvscad short addit acceler converg speed abpo adapt strategi shrink permiss sourc region improv perform abpo tvscad main result result numer simul vivo xenograft mous experi show propos method achiev superior accuraci spatial local morpholog reconstruct bioluminesc sourc signific abpo tvscad effect robust reconstruct method blt hope method promot develop optic molecular tomographi | D000465;D041622 | T170;T060 |
36,220,010 | vitro applic drug load hydrogel combin print porous scaffold titanium mesh three dimension titanium alloy scaffold play key role address oral maxillofaci bone defect provid specif environ structur bone growth develop two main caus implant surgeri failur asept loosen bacteri induc implant associ infect make bone defect implant effect long time ideal scaffold take account two function osseointegr anti infect therefor basi low elast modulus ti ta nb zr ttnz alloy develop research group earli stage studi intend combin vancomycin load hydrogel print hole porous titanium alloy scaffold endow print ttnz scaffold antibacteri properti antibacteri properti complex investig zone inhibit test adhesionfre antibacteri test effect composit system osseointegr investig aspect cell adhes cell prolifer osteogenesi relat gene express result show load wt wt vancomycin affect structur chitosan hyaluron acid hydrogel properti hydrogel examin scan electron microscopi fourier transform infrar degrad experi vitro vancomycin releas experi vitro combin porous scaffold drug load hydrogel exhibit slower drug releas rate longer releas time addit vitro studi found ttnz scaffold load wt vancomycin certain effect express osteogenesi relat gene cell antibacteri effect best porous scaffold load wt vancomycin hydrogel ttnz scaffold inhibit cell prolifer adhes alkalin phosphatas activ osteogenesi relat gene ex pression antibacteri effect free bacteria good ttnz scaffold load wt vancomycin studi complement advantag two control local releas rate vancomycin provid new idea futur print titanium alloy stent anti infect | D020100;D048271 | T121;T109;T122 |
36,220,008 | dynam adapt photoreceptor gain control retina host process need convert extern visual stimuli neural code light phototransduct convers electr signal involv biochem cascad ionic regul differ kind coupl among relev process creat nonlinear process scheme light depend adapt respons dynam adapt model formul recent year excel phenomenolog candid resum phenomena singl feedforward process scheme work analyz descript high nonlinear condit find respons match result detail microscop model develop reproduc electrophysiolog record horizont cell delay light depend gain factor incorpor descript respons excel agreement even span sever order magnitud light intens contrast durat simpl complex stimuli extend model may instrument studi retin function enabl link microscop domain understand signal process properti incorpor spatial extend retin network | D012160;D008027 | T023;T070 |
36,220,005 | assess anastomosi radic prostatectomi review avail diagnost method radic prostatectomi mani institut perform cystographi exclud vesicourethr anastomot leakag remov urethr cathet review diagnost method exclud leakag compar refer standard cystographi | D057868;D014521 | T023;T046 |
36,220,004 | develop fluoresc dual fret probe simultan detect caspas caspas activ relat quantif multi fret three fluorophor probe contain coumarin fluorescein rhodamin b two enzymat cleavabl linker synthes optim simultan activ detect relat quantif two proteas caspas caspas probe design ratiometr singl excit tripl emiss system show specif chang fluoresc intens upon enzymat cleavag individu linker model mixtur well cell lysat activ caspas caspas respons initi extrins intrins apoptot pathway respect probe propos singl chemic tool could help deciph mechan cell death induc various stimuli main advantag probe simplic prepar use convent organ synthesi easi applic measur evalu result | D005456;D031541 | T059;T130 |
36,220,003 | discoveri potent egfr alk dual mutat inhibitor contain n cyclopropylsulfinyl phenyl amino pyrimidin yl amino phenyl acrylamid scaffold seri egfr alk dual inhibitor contain sulfoxid cyclopropyl group design synthes lead compound show signific activ egfr alk enzymat cellular assay studi anti tumor mechan indic could effect block phosphoryl egfr alk protein effect inhibit prolifer induc apoptosi h tumor cell block cell cycl reduc mitochondri membran potenti inhibit migrat h cell vivo studi compound signific subsid tumor tissu nude mice without obvious toxic | D066246;D000970 | T116;T192;T121;T109;T126 |
36,220,002 | natur carbazol alkaloid murrayafolin display potent anti neuroinflammatori effect direct target transcript factor sp lps induc microgli cell neuroinflamm lead caus neurolog disord carbazol alkaloid isol medicin plant murraya speci rutacea exhibit wide pharmacolog activ particular neuroinflamm howev under cellular target molecular mechan still remain unclear current studi found murrayafolin carbazol alkaloid obtain murraya tetramera potent inhibit product neuroinflamm mediat nitric oxid tnf il il lps induc bv microgli cell perform thermal proteom profil tpp strategi identifi specif protein sp potenti cellular target moreov perform surfac plasmon reson spr cellular thermal shift assay cetsa drug affin respons target stabil drat assay confirm direct interact sp furthermor downregul sp express bv cell use sirna transfect observ sp knockdown signific antagon mediat inhibit neuroinflamm mediat product meanwhil sp knockdown also mark revers mediat inactiv ikknf b pjnk mapk pathway final vivo studi reveal signific suppress express iba tnf il increas number nissl bodi brain lps induc mice taken togeth studi demonstr exert obvious anti neuroinflamm effect direct target sp therebi inhibit nf b mapk signal pathway find also provid promis direct pharmacolog target sp anti neuroinflamm therapeut well novel agent develop | D000470;D032101 | T002;T131;T121;T109;T123 |
36,219,988 | safeti index evalu urban roundabout recent grow interest road safeti assess base examin characterist road aim identifi presenc risk factor approach name road assess program network wide road safeti assess requir eu direct road infrastructur safeti manag reliabl procedur assess inher safeti element road network requir conduct roadway safeti assess provid contribut toward develop procedur network wide road safeti assess paper develop valid safeti index si evalu urban roundabout si assess roundabout level well roundabout approach level procedur detect safeti issu largest contributor crash risk order identifi safeti measur provid greatest crash reduct roundabout si formul combin two compon exposur road user road hazard exposur risk factor increas probabl involv crash risk index procedur consid detail safeti issu general safeti issu comput risk index criteria identifi rank safeti issu defin si procedur valid sampl urban roundabout locat rome itali sampl consist singl lane roundabout two lane roundabout total number approach equal roundabout si score eb crash estim compar refer whole roundabout well singl roundabout approach correl si score eb estim high signific roundabout level r p valu well approach level r p valu result spearman rank correl analysi provid valid si indic rank si eb estim agre confid level roundabout level well approach level | D000063;D004779 | T078;T067;T037 |
36,219,987 | general trust traffic violat moder role individu dimens traffic crash take well million live everi year main caus driver behavior traffic violat driver attitud belief root whether traffic violat commit make import explor contribut disobedi traffic law general trust one influenti factor interperson behavior yet studi empir context drive behavior general traffic violat specif use data particip european countri studi examin relationship general trust commit traffic violat pay attent differ countri score high low individu multilevel mix effect logist regress analysi show countri high individu score probabl commit traffic violat increas signific general trust increas associ general trust traffic violat decreas countri individu level decreas find implic discuss suggest futur research | D000063;D001334 | T056;T067;T037 |
36,219,983 | generat cda gene knockout human embryon stem cell line use crisprca cda receptor fc portion immunoglobulin g involv antibodi depend cellular cytotox adcc natur killer cell zhu et al antibodi depend enhanc ade virus infect wan et al howev role cda human embryon stem cell model develop mere document henc illustr role cda human cell develop report cda knockout human embryon stem hesc cell line via crisprca mediat gene knockout cda mutat cell line display normal karyotyp pluripot stem cell marker gene express differenti potenti | D000066449 | T025 |
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