PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,220,558 | optimis weight gain pregnanc key challeng solut matern obes prevent pregnanc high risk period excess gestat weight gain subsequ obes develop antenat lifestyl intervent prioritis optimis weight current evid demonstr efficaci associ reduct risk advers matern neonat outcom yet evid guid field efficaci base implement research within real world set lack sever key challeng remain discuss key consider support implement access relev effect low cost lifestyl intervent routin pregnanc care includ identifi compon lifestyl intervent effect pragmat guidanc conduct implement research improv rigour report ensur learn implement captur recognis address socioecolog aspect obes prevent includ support women live socioeconom disadvantag reduc weight stigma | D000079262;D011248 | T046;T033 |
36,220,557 | commerci determin unhealthi diet unhealthi diet lead risk factor obes non communic diseas food choic made within context peopl social circumst well broader food environ shape extens food beverag industri practic includ market financi polit activ undertaken increas sale consumpt high process food beverag reduc burden unhealthi diet clear need govern led action disrupt balanc power current favour commerci interest public health | D001628;D003132 | T081;T078;T057;T168;T097 |
36,220,556 | better understand scienc realiti obes urgent need effort prevent treat obes need ground scienc histor focus individu respons ineffect halt rise obes preval need better understand environment biolog driver weight gain help reduc weight bias stigma identifi effect polici action | D009765 | T047 |
36,220,543 | tmt base quantit proteom analysi indica rice cultivar reveal novel compon signal pathway might play role grain length regul grain length one import rice grain appear compon better understand protein regul grain length indica rice tandem mass tag tmt label combin lc msms analysi use quantit identif differenti regul protein compar six long grain cultivar meib longfengb yexiangb fengtianb wantaib dingxiangb short grain cultivar bob respect total protein detect quantit analysi compar protein content six long grain cultivar short grain cultivar protein signific regul consist uniqu accumul protein uniqu accumul protein kegg pathway analysi reveal accumul protein involv metabol pathway biosynthesi secondari metabolit phenylpropanoid biosynthesi four accumul protein mayb involv signal pathway grain length regul lc prmms quantit analysi use analyz differenti express protein result almost consist tmt quantit analysi qrt pcr analysi result show transcript level alway parallel protein content studi identifi mani novel grain length accumul protein quantit proteom approach provid candid gene studi grain size regulatori mechan signific rice grain length one import characterist influenc appear yield six long grain cultivar meib longfengb yexiangb fengtianb wantaib dingxiangb obtain guangxi provinc china one short grain cultivar bob obtain guangxi provinc china use compar analys total differenti express protein dep identifi use tmt base proteom analysi number dep increas grain length increas dep may relat rice signal pathway grain size regul total dep regul least four long grain cultivar compar short grain cultivar bob protein accumul protein accumul six long grain cultivar find provid valuabl inform better understand mechan protein regul grain length rice | D012275 | T168;T002 |
36,220,542 | potenti proteom studi process meat product proteom field grown rapid sinc emerg mid reach mani disciplin food technolog applic proteom techniqu studi complex biolog sampl food specif meat product allow scientist deciph under cellular mechan behind differ qualiti trait late much emphasi place discoveri biomark facilit predict biochem transform product provid key inform paramet associ traceabl food safeti review studi focus contribut proteom improv process meat product differ techniqu strategi recent success carri studi proteom product help develop food higher sensori qualiti ensur consum safeti earli detect microbiolog contamin fraud signific food industri academ world work togeth aim respond market demand alway seek excel particular meat industri face seri challeng achiev sensori attribut accord standard requir consum maintain high level safeti transpar avoid deliv adulter andor contamin product review work expos aforement challeng attempt solv proteom technolog discuss latest outstand research regard undoubt contribut improv qualiti extens word meat product provid relev knowledg field proteom research | D008461 | T168 |
36,220,523 | dynam inflammatori chang neurovascular unit ischem stroke ischem stroke acut brain injuri major caus disabl mortal worldwid result perman temporari cerebr arteri occlus thrombolysi antithrombot therapi thrombectomi wider therapeut window led reduc stroke mortal howev post stroke patholog mechan still elus involv sustain inflamm cellular dysfunct hinder recoveri thus attent shift toward complex interact neurovascular unit nvu import role progress inflamm recent review summar physiolog function compon nvu function blood brain barrier permeabl cerebr blood flow regul inflamm progress addit describ inflamm relat patholog chang affect nvu conclud dysfunct nvu contribut inflamm progress review may provid idea potenti therapi target nvu improv prognosi | D000083242;D020521;D002545 | T047;T046 |
36,220,519 | optim surgic sequenc colorect cancer liver metastas patient receiv colorect cancer resect simultan liver metastasi resect multicentr retrospect propens score match studi littl evid regard optim surgic sequenc colorect cancer liver metastasi crlm patient undergo colorect resect simultan liver metastasi resect | D015179;D008113 | T191 |
36,220,515 | predict readmiss due sever hyperglycemia hyperglycem crisi episod studi aim investig readmiss pattern risk factor patient experienc hyperglycem crisi | D006944;D016883;D006943 | T047;T033 |
36,220,513 | zerumbon major sesquiterpen syringa pinnatifolia hemsl exert sedat effect regul gabaerg nervous system zerumbon zer humulan sesquiterpenoid isol syringa pinnatifolia hemsl sp content account volatil oil total ethanol extract tee repres one characterist ingredi sp repres mongolian medicin anti khii anti asthma clear heat effect sp use treatment cardiovascular diseas upset insomnia symptom | D031662;D012717 | T109;T002 |
36,220,512 | review plant resourc import medicin licoric glycyrriza radix et rhizoma various effect includ tonifi spleen qi clear heat toxic substanc elimin phlegm reliev cough pain harmon effect medicin wide use pharmaceut food industri | D006035;D014315;D010946 | T109;T002 |
36,220,511 | anti cervic cancer effect compound yangsh granul pikakt pathway base network pharmacolog compound yangsh granul characterist chines prepar cervic cancer use fudan univers shanghai cancer center consist hedyoti diffusa herba solani lyrati herba rubia radix et rhizoma echinopsi radix angelica sinensi radix codonopsi radix atractylodi macrocephala rhizoma | D004365;D002583 | T121;T123;T191 |
36,220,510 | bioactiv fraction stir fri radix paeonia alba regul il stat signal pathway allerg asthma mous radix paeonia alba rpa tradit chines medicin use frequent treatment asthma previous studi demonstr dichloromethan fraction stir fri rpa fdcm enhanc effect anti allerg asthma compar dichloromethan fraction rpa dcm | D018926;D001249 | T121;T047 |
36,220,509 | phytochem character anti inflammatori activ water extract gentiana purpurea root gentiana purpurea one import medicin plant norway th th centuri root use differ type gastrointestin airway diseas | D030012 | T002 |
36,220,508 | piperlongumin overcom imatinib resist induc proteasom inhibit chronic myelogen leukemia cell piper longum l herbal medicin use india asian countri prescrib routin rang diseas includ tumor piperlongumin natur product isol piper longum l receiv widespread attent due various pharmacolog activ anti inflammatori antimicrobi antitumor effect | D015464;D001688;D000970 | T191;T109;T123;T121 |
36,220,500 | zinc selenium mitig heavi metal mixtur pb al hg mn mediat hepat nephropathi via modul oxido inflammatori status nfkb signal femal albino rat studi evalu protect role zinc selenium heavi metal mixtur hmm induc hepat nephropathi twenti five femal wistar albino rat weight match divid five group five femal rat group control receiv deioniz water group receiv heavi metal mixtur hmm mgkg pb mgkg hg mgkg mn mgkg al group co administ metal mixtur zn se zn se respect treatment oral gavag day anim sacrif pentobarbit liver kidney harvest test zn se zn se reduc metal accumul liver kidney hmm exposur caus non signific increas ast alp alt tp signific increas il tnf nf kb hmox nfr mda compar control essenti trace element signific decreas il tnf nf kb hmox nfr comparison hmm group treatment zn se zn se signific revers hhm mediat decreas sod level hmm trigger degen chang central vein show vacuol connect tissu fragment lymphocyt infiltr revers essenti trace element essenti trace element supplement protect hmm mediat hepato renal impair | D012643;D014131;D019216;D008628;D007674 | T047;T131;T121;T123;T196 |
36,220,451 | genom scale metabol model combin singl molecul real time sequenc analyz actinomycet chromosom heterogen rapid develop biotechnolog provid new perspect observ help gradual understand signific genet instabl actinobacteria high frequenc delet extrem abnorm methyl chromosom suggest might relev two phenomena suspicion use singl molecul real time smrt sequenc map genom level methyl one branch actinomycet saccharopolyspora erythraea ring shape chromosom erythraea use analysi studi share high unstabl phenotyp trait evidenc divers spore morpholog fluctuat erythromycin product multipl amplif genom island close replic initi site methyladenin delet genom island suggest interact restrict modif r system transpos element provid explan divis labor genom heterogen actinomycet | D039903;D016930 | T007 |
36,220,450 | screen identif cnih gene associ cell prolifer gastric cancer base larg scale crispr cas screen databas depmap gastric cancer common malign tumor digest tract studi aim identifi candid gene associ prolifer surviv gastric cancer cell crispr cas screen data may provid new therapeut target gastric cancer patient | D018160;D013274 | T191;T116;T192 |
36,220,449 | moder exercis reveal influenc actn rx ace id polymorph physic perform non athlet activ subject genom variat contribut vast major interindividu differ may decis influenc sport capabl studi conceiv mean find exact polymorph start physic discrimin polymorph studi two best character one ace id actn rx germlin variant determin cohort healthi volunt univers environ underw seri physic evalu includ cooper test meter sprint test vertic jump test initi statist associ found genet effect mask subject sedentari lifestyl physic activ volunt consid ace actn genotyp found impact heart rate cooper test p valu respect actn found correl total distanc cover test p valu therefor consid paradigmat exampl environ might hide genet effect genotyp differ aris upon train | D000185;D015444;D007703;D000076604 | T116;T061;T123;T126;T040;T129;T056;T032 |
36,220,448 | import pharmacogen polymorph landscap potenti clinic relev chines mongolian studi genotyp pharmacogen individu inner mongolia autonom region china aim find distinct pharmacogenom variat among mongolian popul investig potenti clinic oper gene drug connect genotyp phenotyp correl differenti variat mongolian popul | D001094;D051546;D019389;D000071184 | T045;T126;T116 |
36,220,447 | swim exercis nano l arginin supplement improv oxid capac autophagi relat gene soleus muscl age rat present research aim evalu effect swim exercis chitosan coat l arginin mitochondri oxid bcl interact protein bnip nip like protein nix b cell lymphoma extra larg bcl xl autophagi relat protein light chain lc express soleus muscl age rat experiment research male wistar rat assign five group random young old old nano l arginin nano l old exercis ex old nano l arginin nano l exercis ex n perform swim exercis program five day week six week determin relat strength rat perform intervent repetit maximum rm test done pre post test exercis program start min four session gradual increas min time maintain complet train period l arginin coat chitosan nanoparticl given rat l arginin supplement group via gavag dosag mgkgday five day week six week addit rat group fed normal diet kcalg energi fat upon complet protocol implement rat sacrif soleus muscl fix frozen determin hematoxylin eosin h e stain immunohistochemistri ihc gene express analysi level reactiv oxygen speci ros total antioxid capac tac result present research indic swim exercis nano l arginin improv strength histolog muscl tissu old rat p age signific increas express nix bnip p reduc bcl xl gene express p express lc protein also increas age p therapeut intervent combin treatment old nano l ex old anim reduc amount protein soleus muscl p ros valu also show signific reduct old nano l ex group compar old group moreov tac valu show signific decreas old old ex group comparison young group use arginin supplement especi nano form along swim exercis seem reduc oxid damag elder muscl tissu posit effect structur function soleus muscl sinc intervent signific effect lc protein studi divers measur method autophagi suggest | D048271;D010805 | T121;T109;T038 |
36,220,440 | z scheme cuof go heterojunct photocatalyst enhanc photocatalyt perform elimin tetracyclin cuof go z scheme heterojunct catalyst success synthes use photocatalyst remov tetracyclin aqueous solut cuof go heterogen catalyst combin narrow bandgap semiconductor cuo oxygen vacanc fe oxygen contain reaction site go without addit activ persulf h photocatalyt perform decompos tetracyclin excel compar go fe cuo cuof go exhibit superior photocatalyt perform visibl light radiat cuof go generat h main respons activ group tc degrad effect various ph catalyst reus degrad perform evalu optim condit cuof go remov tetracyclin obtain ph catalyst dosag mgl tc concentr mgl near tetracyclin decompos studi great potenti treatment wastewat contain various antibiot | D006861;D062065 | T083;T121;T069;T130;T197 |
36,220,439 | anthropogen impact acceler antibiot resistom divers mangrov sediment indian sundarban mangrov situat converg zone fresh marin water prone pollut deforest studi explor microbiom structur function antibiot resistom indian sundarban taxonom chao estim divers highest uninhabit kalash lowest godkhali experi consider human activ alpha divers show negat correl p pah acenaphthen r acenaphthylen r fluoranthen r fluoren r phenanthren r biochem paramet phosphat r salin r signific p posit correl data suggest import physicochem paramet maintain mangrov microbiom taxonom composit domin proteobacteria site domin arg rpob cpxr ompr camp baca compar sundarban mangrov sediment resistom mangrov site india kerala china guangxi hainan shenzhen suggest resistom indian mangrov signific p higher arg divers compar chines mangrov yet abund arg signific p lower indian mangrov pose much greater risk enrich studi suggest anthropogen activ pollut degrad microbiom divers disturb microbiom function enrich arg | D014874;D010616 | T121;T109;T131 |
36,220,438 | assess environment accept potenti artifici reef materi use two ecotox test luminesc bacteria sea urchin embryogenesi ecotoxicolog analysi construct product relat unexplor area intern level aquat toxic test construct product recommend recent freshwat environ howev biolog effect altern materi marin ecosystem still consid studi main aim assess environment impact altern mortar propos artifici reef ar materi ar specimen develop print base cement geopolym mortar use recycl sand glass seashel purpos leach test two differ toxic bioassay luminos reduct marin bacteria vibrio fischeri microtox success embryo larval develop sea urchin paracentrotus lividus conduct leach result note mobil trace element consid raw materi mortar meet inert landfil limit except mo se sb leachat geopolym mortar howev result obtain bioassay show low environment accept mortar contain shell sand probabl due degrad organ matter adher shell hand cement mortar obtain better result geopolym mortar regardless aggreg use show certain consist leach behaviour sinc present lowest mobil trace chemic element therefor result support environment accept potenti use altern materi product ar | D014131;D047328 | T121;T123;T204;T196 |
36,220,437 | step scheme nickel aluminium layer doubl hydroxidesbiochar heterostructur photocatalyst synergist adsorpt photodegrad tetracyclin improv adsorpt abil layer doubl hydroxid ldh consid promis strategi promot photodegrad aqueous pollut work nickel aluminium layer doubl hydroxid nial ldh biochar nanocomposit prepar use simpl coprecipit method appli synergist adsorpt photodegrad tetracyclin tc aqueous solut addit govern tc remov mechan nanocomposit reveal nial ldhbc sampl show strong adsorpt photodegrad tc langmuir maximum tc adsorpt capac optim nial ldhbc reach mgg much better nial ldh mgg biochar mgg besid tc photodegrad rate constant nialbc time nial ldh bc respect nialbc exhibit maximum tc adsorpt photodegrad effici min compar nial ldh bc rate constant modifi elovich kinet model synergist adsorpt photodegrad nialbc min highest among composit nial ldhbc signific larger bet surfac area nial ldh bc step scheme scheme heterostructur construct interfac bc nial ldh nanocomposit facilit transfer photo induc charg work demonstr combin nial ldh biochar creat synergi tc adsorpt photodegrad promis green strategi | D000535;D014874 | T121;T131;T196 |
36,220,436 | associ serum per polyfluoroalkyl substanc gestat anemia differ trimest zhuang ethnic pregnanc women guangxi china gestat anemia complic pregnanc low level hemoglobin hb link advers pregnanc outcom previous studi report pfass strong associ hb red blood cell indic hb suscept effect pfass howev evid regard effect per polyfluoroalkyl substanc pfass gestat anemia current limit therefor import explor effect pfass anemia chines pregnant women | D005466;D004785;D000740 | T047;T109;T131 |
36,220,435 | hydrochem interpret groundwat yinchuan basin use self organ map hierarch cluster self organ map som emerg altern tradit cluster method hydrochem analysi groundwat due visual high dimension data studi combin method som hierarch cluster appli analyz hydrochem characterist groundwat phreatic aquif yinchuan basin china groundwat sampl classifi som project neuron group cluster hierarch cluster result show exist three princip type groundwat studi area name high hco type cluster high type cluster high na type cluster chadha diagram indic phreatic water yinchuan basin main belong group alkalin earth exceed alkali metal n rock weather evapor crystal predomin mechan hydrogeochem evolut phreatic groundwat present studi suggest combin method som hierarch cluster provid reliabl approach interpret hydrochem characterist groundwat high dimension data | D014874;D060587 | T082;T131;T081;T070 |
36,220,434 | repres subsampl method chemic identif microplast particl environment sampl chemic identif microplast time consum especi particl numer save resourc subsampl particl often select chemic identif standard subsampl protocol current exist method vari wide often lack evid repres limit conclus cross studi compar studi determin best practic subsampl microparticl chemic identif base two research object quantifi proport plastic anthropogen natur particl quantifi divers materi type use publish dataset microparticl count chemic identifi test subsampl method particl select either individu sampl group sampl treat collect determin overal particl select random provid repres subsampl lowest effort subsampl method must also inform research object fewer particl requir accur repres proport plastic anthropogen natur particl present compar repres divers materi type accur repres particl divers research must understand particl divers within environment matrix question inform necessari sampl volum overal harmon repres subsampl practic allow improv compar among studi transpar data report robust conclus | D000080545;D014874 | T131;T122 |
36,220,433 | enhanc generat reactiv oxygen speci pyrit iii oxid immobil vital role fe ii migrat convers arsenic environ usual accompani redox iron bear miner instanc oxid pyrit generat reactiv oxygen speci ros affect speci arsenic type role ros unclear paper demonstr vital role fe ii pyrit format ros result show exogen addit fe ii signific enhanc remov rate iii pyrit bipyridin bpi decreas oxid iii complex fe solut whilst edta enhanc oxid iii boost autoxid fe addit neutral ph superior oxid iii remov total arsenic import methanol sod enzym pmos inhibit iii oxid respect indic oh main contributor iii oxid fe iv contribut small part iii oxid content v fes fe iii system higher fes iii system confirm vital role fe ii iii oxid lepidocrocit produc singl fe system detect fes iii system thus presenc miner surfac chang oxid product fe acceler oxid immobil iii fa fulvic acid ha humic acid acceler oxid iii oxid iii pyrit inhibit certain extent increas phenol hydroxyl group phenol acid find provid new insight oxid speci pyrit fe ii system help guid remedi arsenic pollut complex environment system | D001151 | T121;T131;T196 |
36,220,432 | pharmacokinet transderm methyl ethyl propylparaben human follow singl dermal administr paraben common chemic use preserv food cosmet person care product although transderm exposur paraben occur studi human pharmacokinet pk follow dermal exposur paraben scarc studi pk follow dermal exposur paraben determin compar previous find oral exposur paraben mixtur cream contain deuter methyl ethyl propylparaben mep etp prp dermal appli whole arm five male volunt dose gperson min blood urin sampl collect sever interv cours h measur level mep etp prp conjug metabolit use hplc msms result non compartment analysi averag peak valu total sum conjug unconjug metabolit mep etp prp reach h h h indic slower absorpt rate compar oral exposur h termin elimin half live mep etp prp h h h respect fraction urinari excret f ue total mep etp prp respect f ue total unconjug prp follow dermal exposur five time lower three time higher respect compar oral exposur suggest prp relat less metabol conjug form dermal exposur taken togeth dermal exposur paraben lead longer appar half life result higher proport biolog activ unconjug paraben system circul compar oral exposur studi provid insight kinet properti paraben metabolit human | D010226;D003358 | T121;T109;T073;T167 |
36,220,431 | effect live inactiv chlamydomona reinhardtii remov tetracyclin aquat environ develop medic drug wide use tetracyclin brought mani advers effect ecosystem human health tetracyclin pollut water environ becom serious becom emerg environment problem singl cell organ microalga model organ risk assess aquat ecosystem also effici purifi sewag microalga mediat pollut remedi attract attent research paper chlamydomona reinhardtii c reinhardtii use remov tetracyclin aqueous solut remov effici mechan microalga tetracyclin studi result show remov rate tetracyclin activ inactiv microalga densiti cellsml respect c reinhardtii remov tetracyclin biosorpt nonmetabol process microalg cell supernat hydroxyl radic could signific promot remov tetracyclin posit charg tetracyclin electrostat adsorb microalga surfac extracellular polymer substanc microalga biomass promot product ros enhanc abil microalga remov tetracyclin | D016825;D058086;D004785 | T131;T204 |
36,220,430 | evalu membran foul elev temperatur impact algal organ matter membran distil md thermal driven technolog appli desalin water reus utilis sustain energi howev algal organ matter aom could foul membran critic plagu md long term oper stabil studi solubl extracellular polymer substanc sep intracellular organ matter bound extracellular polymer substanc iom bep two algal speci amphora coffeaeformi navicula incerta expos c c c h polypropylen hydrophob membran simul heat aom contact membran insid md unit studi temperatur effect membran foul dissolv carbohydr protein sep iom bep sampl general increas heat heat caus cell lysi releas dissolut carbohydr protein sep iom bep water heat temperatur increas carbohydr releas aom usual increas contact angl membran contact sep iom bep reduc signific heat treatment reduct iom bep larger sep line sem analysi indic membran surfac pore iom bep foul sever sep due higher hydrophob iom bep caus adher membran presenc amphiphil high protein lipid satur fat proport also caus sever foul sem edx analysi indic presenc na cl mg element point carbohydr lipid salt trap foulant aom heat composit direct effect membran integr dictat sever foul md oper | D000077317;D018508 | T057;T123;T052 |
36,220,429 | characterist polycycl aromat hydrocarbon heavi metal water sediment dajiuhu subalpin wetland shennongjia central china insight sourc sediment water exchang ecolog risk polycycl aromat hydrocarbon pah heavi metal hms persist environment issu secondari emiss produc result climat chang human activ observ spatio tempor variat pah hms discuss sourc well sourc sink pah sediment peat twelv surfac sediment surfac water site chosen along direct flow hole dajiuhu area simultan surfac peat water sampl collect peatland sampl continu taken three year sep sep sep respect result show pah hms common sediment peat pah concentr general higher peat water hms concentr relat higher water relat low sediment peat ecolog risk sediment low hms sediment main affect rock weather pah main affect atmospher deposit biomass coal combust vehicl emiss hms pah use indic rock weather human activ dajiuhu area respect water sediment fugac analysi reveal peat sink pah confirm high capac adsorb organ contamin sediment secondari sourc pah releas water attent paid increas fugac fraction ff valu peatland indic peat might convert sink sourc pah | D011084;D014874;D019216 | T109;T131;T196 |
36,220,428 | fate typic organ halogen compound coexist endogen chlorin atom exogen x transform halogen organ advanc oxid process aop extens investig howev current know littl fate halogen pollut presenc exogen halid cl br herein degrad miner rate accumul capac adsorb organ halogen aox chlorophenol chlorophenol cp chlorophenol cp chlorophenol cp trichlorophenol tcp compar fe persulf ps process addit exogen halid result indic exogen x lead decreas chlorophenol degrad miner rate undesir accumul aox generat halogen product toxic precursor chlorophenol result kinet model show cl play import role addit cl br br respons effect br well effect endogen chlorin atom chlorophenol reveal degrad aox format potenti cp highest tcp lowest studi demonstr signific influenc endogen chlorin atom exogen x fate typic organ halogen compound consequ x level positionnumb halogen atom consid simultan treat organohalogen compound | D014874;D002733 | T109;T131 |
36,220,427 | hkme target di ethylhexyl phthalat dehp impair primordi follicl assembl di ethylhexyl phthalat dehp wide use plastic addit grow evid indic endocrin disruptor abl negat affect various reproduct process femal male anim includ human howev precis molecular mechan action complet understood present studi scrna seq perform ovari offspr mother expos dehp day post coitum day post partum primordi follicl pf stockpil establish histolog observ offspr ovari dehp expos mother confirm previous data distinct reduct oocyt enclos pfs focus oocyt scrna seq analys show gene most chang dehp enrich go term relat histon h k methyl moreov observ hkme level epigenet modif h crucial chromatin transcript decreas p dehp treat group compar control newborn ovari cultur vitro dehp effect abolish tamoxifen estrogen receptor antagonist overexpress smyd one specif methyltransferas hkme particular percentag oocyt enclos pf increas dehp plus smyd overexpress group dehp group p accompani upregul hkme collect present result discov smyd hkme novel target deleteri er mediat effect dehp pf format earli folliculogenesi mous highlight epigenet chang promin target endocrin disruptor like dehp | D004051;D052244 | T039;T109;T131;T122 |
36,220,426 | season chang respiratori deposit flux pm pm bound metal dhaka bangladesh due rapid urban fast econom develop aerosol pollut serious environment issu especi bangladesh base bioaccess respiratori deposit dose rdd health risk pm pm bound fifteen metal investig fourteen urban site roadsid marketplac industri commerci area sampl campaign conduct four season winter summer raini autumn decemb novemb beta attenu mass analyz measur particul matter concentr ambient air metal pm fraction analyz x ray fluoresc spectroscopi induct coupl plasma mass spectrometri icp ms airborn trace metal cd zn pb cr cu ni high enrich factor indic anthropogen sourc posit matrix factor pmf categor element origin automobil exhaust industri emiss solid wasteco combust wherea geolog element came earth crustsoil dust winter air mass trajectori arriv india across land indo ganget plain igp region sampl site may aid transport pollut deposit flux metal illustr compar pm pm deposit higher amount metal upper airway comparison pm accumul elev amount metal alveolar region due abil fine particl penetr deeper lower pulmonari region among age group adult inhal higher amount metal child averag mg mg metal per day via pm respect acut health impact caus deposit cancer caus metal alveolar tissu circul bloodstream affect sever organ prolong exposur carcinogen metal pose signific health risk | D000393 | T131 |
36,220,425 | excel captur pb ii cu ii hierarch nanoadsorb fe sio paa h combin experiment theoret studi novel magnet nanoadsorb fe sio paa h synthes graft acryl acid sulfon group fe sio use facil cross link technolog adsorb present water stabil biocompat wastewat exhibit high select captur pb ii cu ii mgg mgg respect ph furthermor adsorpt desorpt process show nanoadsorb still retain high uptak capac cycl reveal structur stabil advanc recycl effect ion exist weak interfer remov pb ii cu ii meanwhil mechan analyz electrostat potenti esp averag local ionize energi ali base densiti function theori dft result indic interact among nanoadsorb heavi metal ion bridg oxygen activ site fe sio paa h adsorb hierarch high water dispers biocompat adsorb potenti new treatment option wastewat | D018508;D014874;D019216 | T196;T057;T131;T052 |
36,220,424 | urapidil unknown known antihypertens essenti arteri hypertens diseas would signific advers affect patient daili activ least most nonetheless signific negat impact cardiovascular morbid mortal tight correl degre hypertens patient age cours commorbid cardiovascular risk factor obvious therefor goal hypertens therapi tri achiev optim reduct blood pressur broader sens reduc risk mention consequ ie reduc morbid reduc mortal antihypertens drug urapidil also use pharmacotherapi brief descript subject articl | D000959;D006973 | T121;T047 |
36,220,423 | care arteri hypertens patient advanc arteri hypertens ah common diseas increas incid preval ah becom worldwid main prevent caus prevent death therefor import obtain earli diagnos conveni treatment still high cardiovascular mortal slovakia posit tail compar european countri close relat failur obtain treatment blood pressur bp target rang ah rare occur isol often cluster cv risk factor dyslipidemia obes escesh guidelin manag arteri hypertens brought sever new concept manag arteri hypertens howev import implement recommend european societi cardiolog everyday clinic practic countri | D002309;D006973 | T047;T091 |
36,220,422 | acetylsalicyl acid primari prevent cardiovascular diseas acetylsalicyl acid effect wide accept essenti drug secondari prevent ischem event role primari prevent studi sever decad still remain controversi initi studi show reduct myocardi infarct ischem stroke without affect overal cardiovascular mortal enrol subject treat modern drug procedur primari prevent care today recent publish studi also shown mortal benefit sub popul group patient clinic benefit aspirin continu outweigh risk associ long term use review articl discuss develop asa primari prevent result latest studi year meta analys current indic asa treatment well futur perspect | D002318;D018954;D020521 | T121;T047 |
36,220,421 | develop recommend use venoact drug treatment chronic venous diseas effect articl provid overview develop recommend indic venoact drug treat symptom sign associ chronic venous diseas cvd venoact drug may benefici patient subject problem andor swell lower limb surgeri varicos vein chronic venous insuffici microcirculatori disord indic asymptomat patient cvd prevent varicos vein prevent progress drug proven efficaci clinic trial prefer | D014648;D014689 | T047 |
36,220,420 | acut kidney injuri due antimicrobi therapi one common caus acut kidney injuri aki drug nephrotox larg group drug associ aki includ consider number antimicrobi clinic manifest rang mild form tubular damag signific deterior renal function requir renal replac therapi sever mechan describ although common acut interstiti nephriti acut tubular necrosi crystal nephropathi proximaldist tubulopathi electrolyt abnorm general risk factor antimicrobi induc aki includ pre exist chronic kidney diseas concomit use drug nephrotox potenti prevent earli recognit aki standard approach mitig aki avoid morbid | D058186;D009395;D051436 | T047;T037 |
36,220,419 | prevent treatment cancer associ venous thromboembol interdisciplinari consensus increas volum data experi direct oral anticoagul doac primari secondari prevent venous thromboembol oncolog patient cavt recent lead chang sever intern guidelin reflect chang within condit slovak republ primari prevent cavt recognis oncosurg patient nonsurg patient hospitalis patient low molecular weight heparin still domin primari prevent cavt regard treatment secondari prevent cavt recommend alway consid possibl use doac prove non inferior lmwh howev lmwh prefer doac well warfarin vka patient clinic unstabl condit high risk bleed andor interact system treatment primarili patient intralumin tumour upper part gastrointestin tract genitourinari tumour high risk bleed lack data lmwh still preferd also patient primari tumour metastat diseas central nervous system hemato oncolog | D009369;D054556 | T191;T047 |
36,220,418 | neoadjuv immunotherapi treatment nonsmal cell lung cancer despit improv stage surgic techniqu introduct adjuv chemotherapi stage ii iii nonsmal cell lung cancer nsclc larg number oper patient recurr diseas due breakthrough result immunotherapi advanc stage nsclc studi examin potenti benefit oper patient logic start first studi look use adjuv immunotherapi chemotherapi alreadi shown benefit atezolizumab phase iii studi press releas posit data pembrolizumab indic also publish recent follow studi neoadjuv immunotherapi phase iii trial most switch chemoimmunotherapi regimen possibl continu immunotherapi adjuv administr recent press releas posit result nivolumab neoadjuv chemotherapi therefor high like treatment modal translat standard treatment regimen near futur | D002289;D008175 | T191 |
36,220,417 | antifibrot therapi indic interstiti pulmonari fibrosi idiopath pulmonari fibrosi chronic fibrot interstiti lung diseas progress phenotyp character fibrot lung parenchyma current antifibrot treatment affect pre exist lung parenchyma fibrosi prevent fibrosi progress reduc mortal reduc fibrot work summar fibrot lung process treatment option | D054990;D017563 | T047 |
36,220,416 | covid post covid jekyl hyde modern medicin covid pandem massiv impact whole world lead death milion peopl requir excess restrict larg econom psycholog impact post covid syndrom defin accord czech pneumolog phtizeolog societi complex symptom persist week acut stage covid possibl explain caus exact pathopysiolog mechan frequenc still known data literatur consis present case report patient differ diseas convalesc cours covid post covid syndrom repres larg space research predict persist limit consequ diseas still possibl even though usuali higher incid post covid symptom patient surviv sever covid cours present case report show paradox exact oposit situat | D000086382 | T047;T067 |
36,220,414 | immobil protocol great alter effect metal phosphat modif activityst immobil lipas miner immobil enzym show coupl advantag process influenc immobil protocol effect miner investig lipas thermomyc lanuginosus candida rugosa immobil octyl vinyl sulfon vs octyl block differ nucleophil glutaraldehyd differ ph valu agaros bead stabil activ specif biocatalyst differ differ block vs biocatalyst glutaraldehyd biocatalyst prepar differ ph biocatalyst submit miner use differ metal activ specif stabil effect miner strong depend enzym immobil protocol enzym miner protocol could negat posit present effect depend enzym immobil procedur substrat best case activ could increas two fold factor stabil signific improv mani instanc result highlight great potenti miner immobil enzym improv properti well great interact immobil protocol miner exhibit combin methodolog great increas possibl find biocatalyst suitabl specif process | D004800;D010710 | T126;T116;T130;T197 |
36,220,413 | investig bone regener activ pva nanofib scaffold load simvastatinchitosan nanoparticl induc bone defect rabbit model studi aim prepar electrospun pva nfs incorpor simvastatinchitosan nanoparticl sim cs nps control drug elut scaffold bone regener optim perform design expert softwar establish two factor three level factori design independ variabl appli voltag flow rate pva solutionsim cs nps ratio formul variabl valu optim formula kv mlh respect nfs diamet mesh pore size chosen depend variabl optim nfs evalu morpholog chemic physic addit vitro sim releas scaffold investig along day optimum nfs possess nm diamet size nm poros also show sustain sim releas day achiev desir goal bone regener optim nfs implant within induc bone defect rabbit vivo assess perform cone beam comput tomographi imag bone densiti measur histolog analysi bone morphogenet protein bmp level obtain result prove high potenti optim nfs promot bone regener compar untreat group non medic nfs group free sim group nfs load sim group week implant | D048271;D057139;D053758 | T121;T109;T073 |
36,220,412 | genom wide associ studi rice leaf metabolit volatil metabolit volatil rice oryza sativa close relat develop biotic abiot stress analyz biosynthet pathway regulatori network metabolit volatil sativa genom wide associ studi conduct use divers access singl nucleotid polymorph studi metabolit volatil detect strong genet associ identifi import compound especi stigmasterol tocopherol isoleucin methyl palmitol naringin cymen addit compound signific associ import phenotyp small brown planthopp repel biomass plant height research promot understand biosynthet pathway regulatori network metabolit volatil rice | D012275 | T168;T002 |
36,220,411 | bio sorbent alginatecitr acid sawdustf nanocomposit bead high effici remov malachit green water sawdust product wood relat industri strike featur pollut uptak first time current studi sustain magnet algin composit bead contain citric acid modifi sawdust ca sawdust bio wast fe nanoparticl design novel eco friend composit alginateca sawdustf bead success appli remov cation malachit green mg easi separ magnet field reusabl could mention two signific properti bio sorbent remov percentag mg use alginateca sawdustf bead calcul process well describ langmuir isotherm nonlinear pseudo first order kinet model moreov film intraparticl diffus model found probabl remov mechan | D053761;D014874;D018508 | T057;T131;T073;T052 |
36,220,410 | ph sensit algin hydrogel synergist anti infect work design ph sensit sodium algin hydrogel combat bacteri infect caus tissu damag antibacteri hydrogel prepar use sodium algin citric acid vancomycin one step situ method vancomycin van load hydrogel via revers imin bond control drug deliveri morpholog swell properti antibacteri activ hydrogel character hydrogel shown strong water absorb behavior ph depend perform result weak acid condit drug releas rate van load gel faster neutral alkalin condit follow zero order kinet releas model cumul releas amount could reach min van load gel high effect antibacteri activ weak acid environ combin citric acid vancomycin synergist therapeut effect acut infect drug load hydrogel show good biocompat compar gauz drug load hydrogel exhibit good coagul properti high platelet adhes high fluid absorpt capac proper balanc fluid wound bed work propos simpl algin base drug deliveri system potenti applic field clinic treatment infect | D000464;D000890 | T121;T109;T122 |
36,220,409 | crisprcasa base phototherm platform portabl detect citrus associ alternaria gene use thermomet outbreak citrus brown spot alternaria one destruct citrus diseas addit alternaria speci produc high toxic mycotoxin mass screen valid method control spread alternaria morpholog analysi polymeras chain reaction combin gene sequenc techniqu common use techniqu detect alternaria howev limit either low conveni accuraci low instrument access high cost balanc conveni accuraci test avail low cost develop crisprcasa base phototherm platform portabl detect alternaria gene use thermomet use platform alternaria gene synthet sequenc cultur fungus citrus tomato appl detect use thermomet detect limit pm aid crisprcasa system citrus associ alternaria specif differenti citrus diseas associ microorgan phototherm platform appli analyz citrus fruit sampl collect field good consist result obtain gene sequenc technolog excel perform portabl method show appli screen alternaria resourc poor set | D000528;D002957 | T168;T004;T002 |
36,220,408 | immunomodulatori effect chitosan nanoparticl vaccin deliveri agent lymphat filariasi mucos immun lymphat filariasi parasit diseas caus nematod affect million individu tropic region complex life cycl filari parasit elud protect measur chemotherapi vector control vaccin recombin protein stand one safe effect method filari antigen brugia malayi thioredoxin trx abund larval transcript alt induc recogniz level protect murin anim model chitosan safe non toxic materi ubiquit serv effici carrier adjuv present studi attempt enhanc immun efficaci filari antigen use chitosan nanoparticl cn mucos rout immun studi show oral immun abl produc enhanc humor respons balanc thth antibodi isotyp respons recombin antigen compar intranas rout high level splenocyt cell prolifer p obtain rout cytokin analysi show high level ifn follow il oral rout wherea high level il observ intranas rout result confirm abil chitosan nanoparticl elev immun efficaci antigen oral rout mice | D004605;D048271;D017178;D014612;D053758 | T047;T116;T073;T121;T109;T129;T204 |
36,220,407 | transcriptom analysi ncrna mrna interact leaf senesc tomato increas number non code rnas ncrnas discov recent advanc rna seq nevertheless function ncrnas leaf senesc fulli elucid studi whole transcriptom sequenc employ character express profil mrna lncrna mirna leaf senesc total mrnas lncrnas mirna identifi signific differenti express senesc young leav co express analysi show differenti express de lncrnas potenti regul protein code gene tran target protein code gene predic regul lncrnas cis gene ontolog go kyoto encyclopedia gene genom kegg enrich analysi tran cis target gene reveal de lncrnas particip pathway photosynthesi transport circadian rhythm furthermor virus induc gene silenc vig employ illumin role lncrnas silenc mstrg mstrg two intergen lncrnas signific inhibit leaf senesc induc dark presum attribut downregul express correspond target gene solycg solycg respect notabl solycg solycg encod senesc relat nac transcript factor reactiv oxygen speci ros relat peroxidas respect serv posit regul leaf senesc collect studi provid comprehens express profil lncrnas senesc leaf concurr integr express mrnas mirna | D062085;D018551;D035683 | T002;T123;T168;T114 |
36,220,406 | prepar character amphiphil chitosaniodin composit film antimicrobi materi composit film amphiphil chitosaniodin poli aminoethyl chitosan citronel schiff base iodin pacsc prepar character sem afm ftir h nmr xrd physicochem properti film includ hydrophil water absorpt mechan thermal degrad iodin releas antibacteri properti test cytocompat evalu composit film also perform result show pacsc success prepar good hydrophil water contact angl water absorpt capac water absorpt ratio elast elong break thermal stabil composit film control releas effect iodin reach maximum releas concentr moll pacsc exert synergist antibacteri effect strong antibacteri activ cell viabil apoptosi assay show pacsc good biocompat toward hacat cell therefor pacsc film promis applic medic field antibacteri materi | D048271;D007455;D000890 | T121;T109;T123;T196 |
36,220,405 | novel chimer protein mimick sar cov spike epitop broad inhibitori activ sar cov spike protein mediat virus attach cell fusion viral cell membran membran fusion driven mutual interact high conserv heptad repeat region hr hr subunit spike reason region interest therapeut target covid although hr hr describ transient expos fusion process signific antibodi respons region report design chimer protein imit high stabl hr helic trimer strong bind hr protein broad inhibitori activ wt b ba virus sera covid convalesc donor show signific level reactiv antibodi igg iga hr mimet protein wherea antibodi respons absent sera uninfect donor moreov inhibitori activ antigen protein correl posit structur stabil number amino acid chang hr sequenc indic conform conserv natur involv epitop result reveal previous undetect spike epitop may guid design new robust covid vaccin therapi | D000086402;D000086382 | T067;T047;T005 |
36,220,404 | activ pathway three metabol detoxif phase via regul endogen microrna modul triflumezopyrim toler small brown planthopp laodelphax striatellus falln frequent use insecticid caus environment hazard also lead pest develop insecticid resist enhanc metabol detoxif reduct target sensit primari mechan insecticid resist clarifi regulatori pathway resist mechan state pivot theoret foundat delay insecticid resist develop show three endogen microrna pc p pc p pc p requir small brown planthopp sbph modul triflumezopyrim toler via activ pathway three metabol detoxif phase twenti one regul mirna acquir pc p pc p pc p three signific regul mirna triflumezopyrim exposur mortal sbph signific increas supplement pc p pc p pc p triflumezopyrim exposur moreov interact pc p cytochrom p cypfl pc p glutathion transferas gstd udp glycosyltransferas ugtf pc p atp bind cassett transport abca systemat demonstr dual luciferas report assay besid mortal sbph signific increas knockdown cypfl gstd ugtf abca triflumezopyrim exposur find uncov strategi wherebi sbph weaken three endogen microrna activ pathway three metabol detoxif phase via target cypfl gstd ugtf abca promot toler triflumezopyrim | D035683;D006430 | T123;T204;T114 |
36,220,403 | polysaccharid fruit lycium barbarum l modifi gut communiti profil allevi dextran sulfat sodium induc coliti mice present studi effect purifi fraction polysaccharid fruit lycium barbarum l lbps name lbps dextran sodium sulfat dss induc coliti mice evalu result show lbps decreas diseas activ index score prevent colon shorten reduc plasma level pro inflammatori cytokin tumor necrosi factor alpha tnf interferon gamma ifn monocyt chemoattract protein mcp prostaglandin e mice coliti lbps could increas relat abund akkermansia bifidobacterium gut microbiota also mitig intestin barrier damag upregul level tight junction protein zo number goblet cell colon moreov result vitro cultur indic growth bifidobacterium longum subsp infanti ccx promot lbps wherea cultur media lbps bacteroid ovatus without addit mucin could enhanc growth akkermansia muciniphila collect result suggest lbps potenti prebiot treatment coliti | D032305;D003092 | T047;T002 |
36,220,402 | prepar character evalu multi biofunct properti novel chitosan carboxymethylcellulos pluron p hydrogel membran load tetracyclin hydrochlorid herein report multifunct hydrogel membran good mechan properti excel antioxid effici broad spectrum antimicrobi activ purpos seri chitosan carboxymethyl cellulos pluron p cht cmc p hydrogel membran prepar blend various tetracyclin hydrochlorid tch content physicochem biolog properti cht cmc p membran comprehens investig increas tch content hydrogel membran present decreas water contact angl decreas water vapor transmiss rate gm h besid increas tch content tensil strength mpa elong break hydrogel membran decreas thick increas data show releas tch reach equilibrium day cumul percentag approxim moreov hydrogel membran exhibit high antioxid capac dpph radic import incorpor tch signific fold enhanc antimicrobi activ hydrogel membran gram posit gram negat bacteria yeast base find hydrogel membran superior properti may serv effect food packag wound heal materi | D048271;D000890 | T121;T109 |
36,220,378 | fine tune interplay calcium bind ionic strength ph modul conform oligomer equilibria respiratori syncyti virus matrix protein envelop rna virus respiratori syncyti virus matrix rsv protein play key role viral assembl uncoat also play non structur role relat transcript modul nucleo cytoplasm shuttl nucleic acid bind abil dissect structur conform chang under switch multipl function identifi ca bind key factor end tackl analysi conform stabil equilibria silico calcul predict two potenti calcium bind site per protom purifi rsv dimer contain one strong bound calcium ion per protom incub rsv presenc excess ca lead increas thermal stabil confirm addit ca bind site moreov mild denatur concentr trigger format higher order oligom otherwis prevent ca satur condit line stabil effect addit low affin bind site hand ca remov chelat ph caus substanti decreas thermal stabil lead format amorph spheric like aggreg assess tem even though ca content modul rsv oligomer propens affect weak rna bind abil rsv undergo substanti conform chang phs result exposur hydrophob surfac increas beta sheet content burial tryptophan residu low ionic strength promot dimer dissoci ph physiolog concentr nacl lead format solubl oligom smaller kda ph insolubl aggreg tubular morpholog ph support fine tune ph furthermor dissoci constant estim low high affin calcium bind site nm respect suggest intracellular calcium sens mechan rsv upon infect uncov fine tune interplay calcium bind ionic strength ph chang compat differ cellular compart play key role reveal divers conform equilibria oligomer high order structur requir stabil virion particl layer molecul posit membran nucleocapsid | D002118;D018113 | T121;T123;T005;T196 |
36,220,375 | label free tumor cell screen base ido mediat tryptophan metabol singl cell level indoleamin dioxygenas ido play critic role inflammatori immunometabol program catalyz oxid tryptophan trp downstream n formylkynurenin ido typic regul malign tumor make potenti biomark cancer diagnosi show effect strategi tumor cell detect integr ido activ assay singl cell encapsul droplet microfluid platform high throughput bioanalysi mix cell well cofactor encapsul individu droplet act dynam microreactor ido catalyz oxid trp pico inject biosens ensembl consist macrocycl cucurbit uril q fluoresc guest rapid robust screen tumor cell fluoresc signal achiev minut report trp deplet expand scope convent antibodi base detect protein biomark result repres first exampl quantifi ido enzymat activ singl cell level high throughput perform therefor promis warn sign earli diagnosi tumor cell | D014364;D009369 | T046;T116;T121;T191;T109;T123 |
36,220,373 | acquir von willebrand syndrom avw acquir von willebrand syndrom avw rare bleed disord caus von willebrand factor vwf dysfunct various type sever clinic manifest differ intens bleed given divers vwf disord avw usual occur adult patient negat person famili histori bleed symptom associ under diseas recent year vwf dysfunct common attribut cardiovascular autoimmun lymphoprolif myeloprolif comorbid true preval avw unknown sinc mani case may clinic laboratori silent remain undiagnos thus higher incid expect mention specif patient popul present case report year old patient first episod bleed manifest newli diagnos vwf dysfunct describ case tri present diagnost treatment option avw includ pitfal draw attent situat think avw | D014842;D014841 | T121;T047;T123;T116 |
36,220,372 | posit import pharmacovigil czech republ world pharmacovigil integr part medicin alway risk side effect use medic complet trivial side effect life threaten fatal pharmacovigil practic prevent side effect least reduc incid especi develop prevent measur base advers drug reaction adr data evalu articl discuss general concept pharmacovigil compar individu pharmacovigil system sever countri region | D064420;D060735 | T046;T037;T062 |
36,220,371 | recurr urinari tract infect kidney transplant patient polycyst kidney kidney transplant routin method use treat end stage renal diseas kidney transplant patient patient autosom domin polycyst kidney diseas adpkd success kidney transplant recurr urinari tract infect also occur initi asymptomat patient | D016030;D007690;D016891;D014552 | T061;T047;T190;T019 |
36,220,367 | cardiorespiratori rhythm brain oscillatori activ cognit review evid propos signific bodi essenc ensembl interact system biorhythm nest multipl timescal tradit focus studi bodi brain interact clarifi way brain orchestr function bodi recent decad theori build opposit causal direct name differ bodi system influenc brain mind dramat increas despit influenti theori direct research evid link bodili rhythm brain cognit scatter review exist evid electrophysiolog activ brain one hand percept cognit hand depend phase physiolog cycl bodi specif heartbeat respir summar accumul evid human anim studi implic theoret reason last besid elabor cycl bodili rhythm influenc brain signal perceptu cognit function present potenti explan answer link might exist | D003071;D001921 | T023;T041 |
36,220,366 | atyp form eye toxoplasmosi childhood case report present outlin acquir atyp form ocular toxoplasmosi ot childhood refer th anniversari discoveri etiolog professor jank czechoslovakia first describ clinic congenit pictur ot characteris macular scar | D000361;D002825;D009443;D031300;D014122;D014126 | T047;T204 |
36,220,365 | chelat band keratopathi long term monitor report clinic result chelat band keratopathi long term follow | D003315;D011788 | T078;T023 |
36,220,364 | primari open angl glaucoma due mutat myoc gene mutat myocilin gene myoc caus trabecular dysfunct thus involv pathogenesi primari open angl glaucoma poag aim studi character describ clinic find two czech famili poag due pathogen variant myoc gene | D005902 | T047 |
36,220,363 | exact intraocular len power calcul formula short eye correl method accuraci eyebal axial length compar accuraci intraocular len power calcul formula examin correl exact axial length eye shorter mm method data hyperop patient underw unev phacoemulsif octob june review intraocular len power patient calcul use formula holladay srkt hoffer q holladay haigi barrett univers ii cataract surgeri postop refract measur refract predict error calcul month phacoemulsif correl axial length absolut error evalu | D007910;D018918;D012030 | T061;T047;T074 |
36,220,362 | analysi corneal anteroposterior ratio optic power use oct aim studi analys valu anteroposterior corneal optic power ratio ap ratio compar result valu theoret model eye defin effect use individu ratio valu approxim total corneal power | D003315;D041623 | T023;T060 |
36,220,360 | advanc health care via artifici intellig concept clinic ever sinc pharmaceut compani face challeng develop new drug product faster econom good qualiti safeti efficaci advent artifici intellig ai comput technolog empow scientist impact societi great scale develop new drug rapid pace artifici intellig scienc engin creat intellig machin use personifi knowledg mani opportun appli ai tool drug discoveri pipelin exampl includ target identif identif biomark molecular model synthesi molecul predict toxic pick lead technolog also help clinic scientist clinic trial design execut real time analysi altogeth facilit process drug discoveri develop also provid better therapi patient apart drug discoveri develop ai also applic area diagnosi drug deliveri patient adher better monitor safeti mani instanc ai perform task better human aid healthcar provid treat patient articl provid discuss ai advanc health care field achiev greater success | D001185;D003695 | T093;T073;T058;T066;T090 |
36,220,359 | recent advanc synthet thymidin phosphorylas inhibitor cancer therapi thymidin phosphorylas tp import enzym synthesi decomposit pyrimidin specif catalyz revers phosphorolysi thymidin thymin deoxi ribos phosphat bodi tp high express mani solid tumor tissu induc angiogenesi anti apoptot effect well tumor growth metastasi therefor tp inhibitor play major role treatment recent year larg number synthet tp inhibitor wide report articl research progress synthet tp inhibitor review includ inhibitori activ cytotox structur activ relationship sar inhibitori kinet mechan interact molecular dock review inhibitor pyrimidin deriv account half lack research biolog activ pyrimidin deriv explor inhibitori mechan excel inhibitor meanwhil applic radiolabel inhibitor assess tp express tumor prognosi cancer chemotherapi vivo rare report addit studi synergist anticanc activ tp inhibitor combin anticanc drug less therefor valuabl look forward develop potent tp inhibitor appli clinic treatment cancer futur | D009369;D000970 | T191;T109;T121 |
36,220,348 | forkhead factor foxl particip ovarian differenti chines soft shell turtl pelodiscus sinensi forkhead transcript factor foxl play major role ovarian develop function mice fish act femal sex determin gene goat function role sex determin gonad differenti yet investig reptil character foxl gene chines soft shell turtl pelodiscus sinensi exhibit zzzw sex chromosom foxl exhibit femal specif embryon express pattern throughout critic sex determin period p sinensi express foxl induc earli stage zz embryon gonad femin estrogen treatment import foxl knockdown zw embryo rna interfer result femal male sex revers character obvious masculin gonad signific regul testicular marker dmrt sox remark regul ovarian regul cypa convers gain function studi show overexpress foxl zz embryo led larg femin genet male product cypa declin dmrt sox find demonstr foxl necessari suffici initi ovarian differenti p sinensi therebi act key upstream regul femal pathway reptilian speci | D019849;D014426 | T045;T042;T014 |
36,220,343 | rna chemic label site specif relat quantif mass spectrometri structur studi neomycin sens riboswitch aptam domain high resolut mass spectrometri use label free direct local relat quantif cmc modif neomycin sens riboswitch aptam domain absenc presenc aminoglycosid ligand neomycin b ribostamycin paromomycin chemic probe ms data free riboswitch show high exposur solvent uridin nucleobas u u u u u part propos intern apic loop u u part propos intern loop found far less expos expect thus data better agreement propos secondari structur riboswitch complex aminoglycosid free rna riboswitch complex neomycin b ribostamycin paromomycin found high similar cmc modif pattern excel agreement previous nmr studi differ chemic probe ms data absenc presenc aminoglycosid ligand quantit rather qualit e nucleobas label differ extent ration stabil propos bulg apic loop aminoglycosid bind studi show chemic probe mass spectrometri provid import structur inform complement techniqu nmr spectroscopi | D058928 | T123;T114 |
36,220,338 | concern safeti topiram pregnanc overview bjrk mh zoega h leinonen mk et al associ prenat exposur antiseizur medic risk autism intellectu disabl jama neurol | D008607 | T048 |
36,220,328 | chang cardiorespiratori function fatigu follow week exercis train women system lupus erythematosus pilot studi patient system lupus erythematosus sle fatigu debilit symptom poor understood pathophysiolog cardiorespiratori dysfunct hypothesis contributor sle fatigu purpos exploratori studi examin chang cardiorespiratori function follow exercis train programm women sle togeth patient report outcom pathophysiolog measur may underli sle fatigu | D008180 | T047 |
36,220,327 | develop intervent picaso optimis palliat care capac social worker flander studi protocol base phase medic research council framework import challeng futur palliat care deliveri grow number peopl palliat care need compar limit qualifi profession workforc exist underus profession potenti optimis certain case social work profess fit well multidisciplinari palliat care practic whose capac remain underus studi aim optimis palliat care capac social worker flander belgium develop palliat care program social work picaso | D010166;D000068217 | T061;T097 |
36,220,326 | understand use evid classif tumour protocol evid gap map classif tumour lung gap evid base tumour classif despit essenti cancer diagnosi treatment patient care charg product updat intern classif classif tumour wct aim adapt evid gap map egm methodolog inform futur edit wct provid visual summari exist evid | D008175;D013899 | T191 |
36,220,325 | experi challeng face patient covid hospitalis particip randomis control trial qualit studi part randomis control trial qualit studi aim identifi experi challeng hospitalis patient covid ill treatment object covid relat perspect object trial particip relat perspect | D000086382 | T047;T067 |
36,220,324 | effect usaid fund obstetr ultrasound servic intervent matern perinat health outcom primari healthcar facil ethiopia propens score match analysi dimension shift health servic deliveri primari healthcar set requir rais matern child well studi aim evalu effect us agenc intern develop fund obstetr ultrasound servic matern perinat health outcom ethiopia primari healthcar facil | D008427;D066087;D011295;D016216 | T058;T060;T033 |
36,220,323 | associ practic code chronic kidney diseas ckd primari care subsequ hospitalis death cohort analysi use nation audit data examin associ practic percentag code chronic kidney diseas ckd primari care risk subsequ hospitalis death | D058186;D006333;D019161;D051436 | T047;T046;T037;T121;T109 |
36,220,322 | valu system immun inflamm index predict poor postop outcom short term prognosi heart valv diseas retrospect cohort studi system immun inflamm index sii novel biomark predict poor outcom tumour nervous system diseas chronic heart failur investig predict valu sii poor postop outcom short term prognosi heart valv diseas hvds | D006349;D008944 | T047 |
36,220,321 | protocol develop spirit consort extens randomis control trial surrog primari endpoint spirit surrog consort surrog randomis control trial rcts may use surrog endpoint substitut predictor patient relevantparticip relev final outcom eg surviv health relat qualiti life translat effect measur surrog endpoint health benefit patientsparticip depend valid surrog henc accur transpar report surrog endpoint need limit mislead interpret trial find howev current explicit guidanc report trial therefor aim develop extens spirit standard protocol item recommend intervent trial consort consolid standard report trial report guidelin improv design complet report rcts protocol use surrog endpoint primari outcom | D012107;D058028 | T081;T170;T169;T062;T096 |
36,220,320 | effect chronic diseas diagnos alcohol consumpt among elder individu longitudin evid china studi estim effect chronic diseas diagnos cdds elder chines individu alcohol consumpt behaviour | D003920;D020521 | T047 |
36,220,319 | clinic effect tenotomi versus tenodesi long head bicep patholog systemat review meta analysi compar clinic effect common surgic techniqu address long head bicep lhb patholog unclear synthesis evid compar clinic effect tenotomi versus tenodesi | D000070636;D053656 | T061;T047;T037;T033 |
36,220,318 | improv qualiti surgic anaesthesia care sub saharan africa systemat review hospit base qualiti improv intervent systemat review exist literatur hospit base qualiti improv studi sub saharan africa aim improv surgic anaesthesia care captur clinic process implement outcom order evalu impact intervent implement learn | D000758;D058996 | T061;T057 |
36,220,317 | servic provis utilis german paediatr primari care practic public health crise protocol mix method covid pedcar studi public health crise pandem caus serious disrupt utilis provis healthcar servic negat effect morbid mortal despit import role paediatr primari care maintain high qualiti healthcar servic crise evid servic utilis provis remain limit especi germani studi therefor explor utilis provis paediatr primari care servic ongo covid pandem barrier facilit | D000086382;D010372 | T047;T091;T067 |
36,220,316 | doctor healthcar profession know overdiagnosi screen deal protocol mix method systemat review overdiagnosi diagnosi diseas would never caus symptom problem harm side effect screen may lead unnecessari treatment cost emot drawback doctor healthcar profession hcps opportun mitig consequ inform patient public also adjust screen method even refrain screen howev unclear extent hcps fulli awar overdiagnosi whether affect screen decis systemat review aim synthesis avail research hcps know think overdiagnosi affect posit screen polici whether think patient public inform | D000088522;D010820 | T097;T033 |
36,220,315 | physic fit children adolesc inflammatori bowel diseas protocol case control studi inflammatori bowel diseas ibd chronic disord gastrointestin tract associ advers health consequ may advers influenc physic activ bodi composit youth effect may lead chang physic fit posit associ health relat outcom aim assess health relat physic fit level paediatr patient ibd compar level healthi match control | D000072599;D015212 | T047;T040 |
36,220,314 | surgic mask wear behaviour covid pandem influenza season cross section studi healthcar profession student staff perspect southern california investig healthcar profession staff student percept wear surgic mask experi covid pandem evalu impact mask wear behaviour futur influenza season | D000086382;D007251 | T047;T067 |
36,220,313 | epidemiolog physic mental multimorbid impact among aborigin torr strait island australia cross section analysi nation repres sampl studi aim examin differ multimorbid aborigin torr strait island peopl non indigen australian effect multimorbid health servic use work product | D000076322;D044468 | T098;T078 |
36,220,312 | caregiv distanc road home care futur flexibl nearbi multimethod qualit studi protocol demograph chang germani accompani birth rate deficit increas life expect one effect age popul increas peopl need care want grow old home care time inform caregiv core resourc german care system due social chang resourc endless process social chang german societi caus eros potenti number inform local caregiv therefor increas import provid condit individu distanc support peopl need care actual abl distanc caregiv broad field pose question intergener intragener solidar balanc work famili care respons systemat research requir opportun limit includ innov technolog whole field care arrang distanc demand differ actor distanc caregiv arrang yet known subject studi | D006699 | T058 |
36,220,310 | incid predictor clinic implic new renal impair follow percutan coronari intervent renal impair post percutan coronari intervent post pci well describ advers effect follow administr contrast media within larg cohort registri patient aim explor incid predictor clinic outcom renal impair post pci | D062645;D051437 | T061;T047 |
36,220,307 | cost optimis analysi expand programm immunis balanc equiti coverag pakistan limit resourc attain maxim averag health servic coverag odd maximis equiti attempt promot greater reach among underserv popul studi examin trade off immunis coverag level equiti children year age pakistan across various subpopul target differ combin immunis servic modal | D007114;D000073887 | T061;T058 |
36,220,306 | geograph regul design incid survey match precis classic survey design whilst requir smaller sampl size case snakebit envenom sri lanka snakebit envenom neglect tropic diseas data worst affect countri limit conduct epidemiolog survey challeng assess util inhibitori geostatist design close pair icp estim snakebit envenom incid | D012909 | T037 |
36,220,305 | past present futur live systemat review bibliometr analysi recent year concept live systemat review lsr attract attent mani scholar institut grow number studi conduct base lsr methodolog focus direct unclear object studi provid comprehens review exist lsr relat studi analys whole pictur futur trend bibliometr | D000086382 | T047;T067 |
36,220,304 | user centr design machin learn health care case studi care manag machin learn ml model success deploy clinic practic one common pitfal across field inappropri problem formul design ml fit data rather address real world clinic pain point | D000069550;D000086825 | T170;T066 |
36,220,303 | mast cell cell axi alter develop coliti depend coliti independ colorect tumour potenti therapeut target via mast cell inhibit colorect cancer crc high mortal rate develop either coliti depend coliti associ ca crc coliti independ sporad crc manner signific debat whether mast cell mcs promot inhibit develop crc herein investig mc activ throughout multistep develop crc human patient anim model | D003092;D015179 | T191;T047 |
36,220,301 | absolut molar mass determin mix solvent secmalsdri mix two near isoviri solvent accur determin polym molar mass averag distribut via size base separ method employ mix solvent remain one great macromolecular character challeng due possibl preferenti solvat wherebi region immedi vicin polym solut becom enrich one solvent compar solvent fraction amount mix case chromatograph baselin differenti detector light scatter photomet differenti refractomet longer provid quantit reflect solvent contribut height individu peak slice therebi introduc error molar mass calcul problem address use near isoviri solvent pair second virial coeffici solvent near equal polym analyz mean preferenti solvat obviat accuraci approach shown via analysi size exclus chromatographi line multi angl static light scatter differenti refractometri detect secmalsdri trio narrow dispers polystyren ps standard cover near fold rang mix two near isoviri solvent name tetrahydrofuran thf toluen calcul molar mass averag distribut shown essenti ident across rang solvent ratio polym size likewis shown constant solvent ratio scenario contrast polym dissolv mix non isoviri non isorefract solvent thf dimethylformamid dmf result latter set experi show larg error calcul result preferenti solvat high g mol g mol narrow dispers polystyren determin thf dmf mix solvent ratio immedi vicin polym examin flip thf dmf due preferenti solvat | D004126;D011137 | T109;T122;T130 |
36,220,300 | crisprcasa system respons dna hydrogel label free detect non glucos target portabl person glucos meter work person glucos meter pgm portabl electrochem devic util sensit detect non glucos target n gene pcb respect dna hydrogel respond crisprca system prepar label free encapsul invertas presenc target repeat sequenc activ casa obtain due perform rca unlik one one recognit activ casa effici cleav multipl singl strand linker dnas dna hydrogel thus releas mani invertas use pgm detect amplif rca crisprca system high detect sensit obtain even use portabl pgm detect limit n gene pcb fm gl respect high specif good practic applic perform develop biosensor use onlin monitor merit low cost easi oper use various target analysi | D015374;D005947 | T059;T121;T075;T123;T109 |
36,220,299 | sequenc specif amperometr detect base doubl probe mode enzym mediat multipl signal electrocatalysi doubl strand dna pmlrar relat fusion gene new electrochem dna biosensor base doubl probe mode enzym mediat multipl signal electrocatalysi construct high sensit determin doubl strand ds pmlrar fusion gene ingeni design two group detect probe includ two thiolat captur probe anchor dual standalon detect unit integr one custom gold electrod four biotinyl report probe hybrid differ segment target singl strand dna ssdna simultan hybrid effici probe target improv prevent reanneal two separ target ssdna compar singl report probe method dramat increas amount biotin introduc numer streptavidin label horseradish peroxidas hrp therebi signific amplifi electrochem signal low background signal combin dual probe mode multipl signal amplif strategi inher electrocatalyt activ hrp result promin electrochem sens perform detect larg fragment target dsdna detect limit low fm furthermor take advantag new detect strategi polymeras chain reaction pcr product enzym digest pcr product nb cell effect analys show great promis develop new class point care platform diseas drug relat gene | D015374;D004277 | T059;T075;T114 |
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