PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,217,024 | dynam sar cov emerg algorithm ration design logic next generat vaccin sar cov worldwid spread evolut result variant contain mutat result immun evas epitop decreas vaccin efficaci acquir sar cov posit clinic sampl compar worldwid emerg spike mutat variant concerninterest develop algorithm monitor evolut sar cov context vaccin monoclon antibodi algorithm partit logarithm transform preval data month pearson correl determin exponenti emerg amino acid substitut aa lineag sar cov genom evalu indic mutat result aa nine ten worldwid preval spike protein chang pearson coeffici r tenth dg preval r valu result algorithm base pattern ten substitut elucid strong posit correl emerg spike protein chang algorithm predict valu har design vaccin relev immunogen epitop monitor next generat vaccin design mab clinic efficaci must keep sar cov evolut virus predict remain endem | D000086382;D000086663;D000086402 | T047;T200;T067;T005 |
36,217,017 | specif disrupt ventral anterior temporo frontal network reveal key implic languag comprehens cognit recent investig rais question role anterior later tempor cortex languag process ventral languag network present languag overal cognit perform rare male patient chronic middl cerebr arteri cerebrovascular accid well document lesion restrict anterior tempor cortex connect via extrem capsul par triangulari inferior frontal gyrus ie broca region perform uniqu patient compar two chronic middl cerebr arteri cerebrovascular accid male patient damag classic dorsal posterior temporo pariet languag system diffus tensor imag use reconstruct relev white matter tract three patient also compar healthi individu patient anterior temporo frontal lesion present flawless fluent speech select impair access lexico semant inform sharp contrast impair speech sentenc comprehens repetit observ lesion classic dorsal languag system present result underlin contribut ventral languag stream lexico semant process higher cognit function activ select control retriev | D032882;D020521 | T047;T041;T080 |
36,217,016 | identifi novel role master regul tal endotheli hematopoiet transit progress generat hematopoiet stem progenitor cell hspcs vitro ex vivo built knowledg development hematopoiesi underscor import understand process hspcs emerg within embryon vasculatur endotheli hematopoiet transit eht transcript regul tal exert essenti function earliest stage blood develop consid dispens eht nevertheless tal express bind partner lmo homolog lyl endotheli transit cell time eht investig function gene use mous embryon stem cell mesc base differenti system model hematopoiet develop show first time express tal endotheli cell crucial ensur effici eht process sustain hematopoiet output find uncov import function tal eht thus fill current gap knowledg role master gene throughout whole process hematopoiet develop | D042783;D006410 | T025;T042 |
36,217,015 | empathi correct mental state infer promot prosoci world rapid increas popul compet earth limit resourc cooper crucial research show empath anoth individu need enhanc prosoci remain unclear whether correct infer inner mental state cognit level ie mental elicit help behavior well appli video base laboratori task probe empathi perform measur mental adult volunt n assess extent will help narrat video replic find empathi induct lead prosoci decis crucial also found correct mental increas willing help evid help clarifi inconsist pictur relat mental prosoci | D004645;D000076563 | T054;T041;T055 |
36,217,014 | numer approach prevent dispers infecti diseas meet room airborn transmiss respiratori aerosol carri infecti virus generat mani concern cross contamin risk particular indoor environ ansi fluent softwar use investig dispers viral particl generat cough event transport dynam insid safe social distanc meet room comput fluid dynam base coupl eulerian lagrangian techniqu use explor characterist airflow field domain main object studi investig effect window open frequenc exhaust layout locat air condition system dispers particl result show reduc output capac rais concentr suspend particl increas travel distanc caus growth individu exposur contamin moreov decreas distanc ventil system instal locat ceil drop fraction suspend particl number individu subject becom infect viral particl drop well result demonstr direct input airflow generat particl fraction suspend particl wherea input shift opposit direct particl inject fraction particl fluid increas | D003141;D014691 | T047;T067 |
36,217,013 | develop larg scale valid watch walk wrist worn digit gait biomark digit gait biomark includ walk speed indic function declin predict hospit mortal howev waist lower limb devic often use design continu life long use wrist devic ubiquit mani larg research repositori includ wrist sensor data wide accept valid digit gait biomark deriv wrist worn acceleromet avail yet describ develop advanc signal process algorithm extract digit gait biomark wrist worn devic valid use week data uk biobank particip gait biomark demonstr good test retest reliabl strong agreement electron walkway measur gait speed self report pace signific discrimin individu poor self report health almost univers uptak smart watch algorithm offer new approach remot monitor life long popul level walk speed qualiti quantiti distribut evalu diseas progress predict risk advers event provid digit gait endpoint clinic trial | D005684;D014953 | T029;T033 |
36,217,012 | effect osteopath techniqu human rest muscl tone healthi subject use myotonometri factori random trial musculoskelet disord msds high preval burdensom putat associ alter human rest muscl tone hrmt osteopath manipul treatment omt common effect appli treat msds reput influenc hrmt arguabl omt may modul alter hrmt under msds howev spars evid even effect omt hrmt healthi subject factori randomis trial perform investig effect myofasci releas mrt muscl energi met soft tissu techniqu stt hrmt corrug supercilii cs superfici masset sm upper trapezius muscl ut healthi subject hamburg germani particip randomis three group alloc ratio receiv treatment accord differ muscl techniqu pair cours three session one week washout period assess effect osteopath techniqu muscl tone f biomechan viscoelast properti r c baselin follow primari object test specif muscl techniqu pair modul effect pre post intervent secondari object use myotonpro rest ancillari investig putat effect may differ sex data analys use descript mean standard deviat quantil induct statist bayesian anova healthi particip randomis three group two subject drop one group n n n cs produc frequent measur error exclud analysi omt signific chang f p p r p subgroup analysi reveal signific sex specif differ f baselin follow advers event report omt modifi hrmt healthi subject may inform futur research msds detail mrt met stt reduc muscl tone f decreas biomechan increas viscoelast properti r c sm ut cs measur howev effect hrmt modul muscl techniqu interact show sex specif differ ftrial registr german clinic trial regist drks | D026301;D009129 | T061;T042 |
36,217,011 | u vi remov dilut aqueous system sorption flotat legaci past uranium mine mill activ nuclear fuel fabric continu caus concern requir assess remedi action research worldwid discharg uranium contamin water environ matter regul world health organ gl romanian legisl ro gl environ health therefor various remov technolog u vi dilut aqueous solut includ chemic precipit ion exchang adsorpt immobil zero valent iron nanoparticl etc extens appli previous research studi remov u vi dilut aqueous system mine water use fe base nanomateri synthes laboratori nms crane et al water res carbon rich aqueous system treat nms remov u vi observ half hour react time remov due high tendenc form stabl solubl carbon complex consid present articl aim investig sorptionflot techniqu use sorbent generat situ fe nh sodium oleat surfact remov u vi dilut aqueous system updat knowledg mechan process order determin remov effici u vi influenc factor studi ph sorbent dose surfact concentr contact time stir rate u vi concentr air pressur pressur water recipi effect accompani heavi metal ion cu ii cr vi mo vi remov effici r monitor maximum valu allow establish optim separ paramet establish process paramet valid real mine water sampl mw high u vi remov effici r obtain sorption flotat techniqu appli remov u vi two type real mine water sampl name simpl pre treat nms respect mine water sampl pre treat nms work two variant without ph correct ph rang molar ratio u vi fe iii u vi naol contact time min stir speed rpm initi concentr u vi mgl air pressur pressur water recipi p nm obtain r found sorption flotat function good r valu stand alon oper tandem nms pre treatment mine water ph adjust prove high effici c u vi mgl | D014501;D014874 | T131;T196 |
36,217,009 | stabl carbon nitrogen isotop identifi nuanc dietari chang bronz iron age great hungarian plain great hungarian plain ghp serv geograph funnel popul mobil throughout prehistori genom isotop research demonstr non linear genet turnov technolog shift copper iron age ghp influenc dietari strategi numer cultur intermix overlap time given complex prehistor cultur demograph process studi aim identifi elucid diachron cultur specif dietari signatur report stabl carbon nitrogen isotop ratio individu nineteen site ghp date year time span earli bronz earli iron age sampl broad indic terrestri c diet nuanc differ amongst popul time suggest exogen influenc manifest subsist strategi slight elev n valu bronz age sampl impli higher relianc protein iron age interest fzesaboni carbon valu typic c veget indic millet consumpt grain compar c ratio corrobor evid outsid ghp earli cultiv middl bronz age final result also suggest local divers subsist economi ghp scythian | D002244;D003300 | T121;T196;T123 |
36,217,008 | gut microbiom insight rrna analysi year period cicada hemiptera magicicada spp brood ii vi x period cicada hemiptera magicicada coevolv oblig bacteriom inhabit microbi symbiont yet littl known gut microbi symbiont composit differ composit among allochron magicicada brood year class emerg parapatr allopatr eastern unit state rrna amplicon sequenc perform determin gut bacteri communiti profil three period brood includ ii connecticut virginia vi north carolina x maryland earli emerg nymph collect ohio result show similar among nymphal gut microbiom morpholog distinct year magicicada name magicicada septendecim brood ii vi year magicicada cassini brood x provid evid core microbiom distinct microbiom burrow soil inhabit nymph general phyla bacteroidet bacteroidota relat abund actinobacteria actinomycetota proteobacteria pseudomonadota repres core acidobacteria genera cupriavidus mesorhizobium delftia preval nymph less frequent adult primari oblig endosymbiont sulcia bacteroidet domin amongst core genera detect chryseobacterium common brood vi x chitinophaga arthrobact renibacterium common brood x pedobact common nymph brood ii vi taxonom assign unclassifi alphaproteobacteria sequenc read allow detect multipl copi hodgkinia rrna gene distinguish separ oper taxonom unit present simultan major emerg brood examin occur year interv studi provid valuabl compar baselin era chang climat | D000069196;D006430 | T007;T001;T204 |
36,217,003 | neural theori count memori keep track number time differ stimuli experienc critic comput behavior propos theoret two layer neural circuit store count stimulus occurr frequenc circuit implement data structur call count sketch common use comput scienc maintain item frequenc stream data first model implement count sketch use hebbian synaps output stimulus specif frequenc second model use anti hebbian plastic track frequenc within four count categori mani trade number categori need distinguish potenti etholog valu categori show model robust track stimulus occurr frequenc thus expand tradit novelti familiar memori axi binari discret two possibl valu final show implement mani count sketch exist insect mushroom bodi | D008959;D009473 | T042;T043;T170 |
36,217,001 | e ubiquitin ligas arih promot antivir immun autoimmun induc mono isgyl oligomer cgas cytosol dna sensor cyclic gmp amp synthas cgas play critic role antivir immun autoimmun activ stabil cgas fine tune post translat modif show ariadn rbr e ubiquitin protein ligas arih catalyz mono isgyl induc oligomer cgas therebi promot antivir immun autoimmun knockdown knockout arih signific inhibit herp simplex virus hsv cytoplasm dna induc express type interferon ifn proinflammatori cytokin consist tamoxifen treat er cre arih flfl mice lyz cre arih flfl mice hypersensit hsv infect compar control addit delet arih myeloid cell allevi autoimmun phenotyp complet rescu autoimmun lethal caus trex defici mechanist hsv cytosol dna induc oligomer activ cgas potenti isgyl k residu catalyz arih find thus reveal import role arih innat antivir autoimmun respons provid insight post translat regul cgas | D015551;D006561;D007370;D044767 | T047;T046;T116;T121;T126;T129 |
36,216,999 | adult born dentat granul cell promot hippocamp popul sparsiti dentat gyrus dg gate neocort inform flow hippocampus intrigu dg also produc adult born dentat granul cell abdgc throughout lifespan contribut downstream fire dynam remain unclear show abdgc promot sparser hippocamp popul spike mnemon process novel stimuli combin tripl dg ca ca ensembl record optogenet intervent behav mice show abdgc constitut subset high fire rate neuron enhanc activ respons novelti strong modul theta oscil select activ abdgc week post birth period increas sparsiti hippocamp popul pattern wherea suppress abdgc reduc sparsiti increas princip cell fire rate impair novel object recognit reduc dimension network fire structur without affect singl neuron spatial represent propos adult born granul cell transient support sparser hippocamp popul activ structur higher dimension respons relev effect mnemon inform process | D018891;D006624 | T023;T026 |
36,216,998 | flexibl neural control motor unit voluntari movement requir communic cortex spinal cord dedic pool motor unit mus activ muscl canon descript mu function rest upon two foundat tenet first cortex control mus independ suppli pool common drive second mus recruit rigid fashion larg accord henneman size principl although paradigm consider empir support direct test requir simultan observ mani mus across divers forc profil studi develop isometr task allow stabl mu record rhesus macaqu even rapid chang forc pattern mu activ surpris behavior depend could accur describ assum multipl drive consist flexibl descend control microstimul neighbor cortic site recruit differ mus furthermor cortic popul respons display suffici degre freedom potenti exert fine grain control thus mu activ flexibl control meet task demand cortex may contribut abil | D009046;D013116 | T025;T023 |
36,216,997 | mendelian random analys support causal relationship brain imag deriv phenotyp risk psychiatr disord observ studi report correl brain imag deriv phenotyp idp psychiatr disord howev whether relationship causal uncertain conduct bidirect two sampl mendelian random mr analys explor causal reliabl idp n individu psychiatr disord n identifi nine idp evid causal influenc risk schizophrenia anorexia nervosa bipolar disord exampl sd increas orient dispers index forcep major associ lower odd schizophrenia risk revers mr indic genet predict schizophrenia posit associ two idp cortic surfac area volum right par orbitali establish brainmr databas http wwwbigconlinebrainmr share result find provid potenti strategi predict intervent psychiatr disord risk brain imag level | D057182;D001523 | T062;T048 |
36,216,990 | design fabric sensit electrochem sensor uranyl ion monitor natur water base poli brilliant cresyl blue new insight propos enhanc detect uranyl ion uo electropolymer brilliant cresyl blue modifi glassi carbon electrod pbcbgce mercuri free pbcbgce sensor appli determin uo water sampl differenti puls adsorpt strip voltammetri dpadsv uniqu combin pbcbgce dpadsv signific improv sensit due polym high electroact area fast electron transfer rate dpadsv current use mm diamet pbcbgce proport uo concentr rang gl v vs sce detect limit gl rsd n reproduc addit sensit uo determin improv use mm diamet pbcbgce enhanc effici uo deposit due higher current densiti mm diamet pbcbgce base dpadsv techniqu could use determin uranyl ion concentr rang gl v vs sce detect limit gl rsd n reproduc henc pbcbgce suitabl candid substitut mercuri electrod graphic abstract | D002244;D008628 | T121;T131;T196 |
36,216,989 | ewt iit surfac electromyographi denois method surfac electromyographi semg often interf nois import impact follow research base semg signal motion intent recognit diseas diagnosi human comput interact paper semg denois algorithm base empir wavelet transform ewt improv interv threshold iit propos elimin nois interfer semg signal propos method use ewt decompos origin semg nois sever empir intrins modal function eimf appli iit function propos paper conduct threshold process eimf method call ewt iit ten healthi subject particip experi correspond semg signal analyz signal nois ratio snr root mean squar error rmse formula see text use evalu effect denois simul experiment result show iit function propos paper combin advantag hard threshold function soft threshold function ewt iit method effect remov nois best denois effect | D058067;D012815 | T062;T066 |
36,216,987 | electrochemiluminesc sensor sensit detect malathion base g c n cdte composit nanomateri self enhanc electrochem luminesc ecl composit materi g c n cdte qds prepar combin g c n cdte qds amplifi ecl signal improv stabil base discoveri g c n cdte qds acetylcholin esteras ach use construct ecl sensor organophosphorus pesticid op detect sensor show strong initi ecl signal pbs contain g c n act co reaction promot amplifi ecl signal cdte qdss system also act carrier larg specif surfac area adsorb cdte qds improv sensit sensor reaction ach acetylthiocholin atcl hinder organophosphorus pesticid op ecl signal enhanc addit op linear relationship display increas valu concentr malathion good linear rang mol l obtain limit detect mol l optim experiment condit result indic sensor promis applic detect op veget sampl | D015374;D019187;D049329;D010575;D045663 | T073;T059;T131;T075;T197 |
36,216,983 | optim protocol sperm cryopreserv vitro fertil rat laboratori rat use biomed research year recent genom edit technolog facilit generat genet modifi rat worldwid develop increas demand effici preserv product rat resourc sperm cryopreserv effici robust mean archiv genet resourc techniqu reduc number anim requir coloni manag previous report protocol rat sperm cryopreserv vitro fertil use frozen thaw sperm describ improv vitro fertil protocol enhanc fertil rate cryopreserv sperm major strain rat optim protocol treatment frozen thaw rat sperm high concentr bovin serum albumin mgml result high vitro fertil rate protocol consist three main step prepar cryopreserv sperm vitro fertil use cryopreserv sperm embryo transfer process take approxim month produc live pup cryopreserv sperm protocol easili implement research technician experi reproduct engin technolog also use albeit practic research technician experi reproduct techniqu sperm cryopreserv vitro fertil protocol rat provid effici system archiv product genet modifi rat transgen communiti | D012661;D012710 | T116;T123;T031;T130 |
36,216,981 | quinolin imidazolebenzimidazol deriv dual multi target hybrid inhibitor anticanc antimicrobi activ two new class hybrid quinolin imidazolebenzimidazol deriv hybrid qib salt qibc cycloadduct design synthes evalu anticanc antimicrobi activ strategi adopt synthesi straight effici four step n acyl n alkyl quatern huisgen cycloaddit vitro singl dose anticanc assay forti six hybrid quinolin benzimidazol compound reveal one qib salt h excel quasi nonselect activ type cancer cell excel pgi area good lethal three other quinolin imidazolebenzimidazol hybrid h h f excel select activ cancer cell line breast cancer mda mb leukemia hl tb five dose assay screen confirm compound h possess excel anti prolif activ gi rang nano molar cancer cell line leukemia hl tb leukemia k leukemia rpmi breast cancer mda mb lung cancer hop ovarian cancer igrov antibacteri assay indic three hybrid qib salt f c excel activ gram negat bacteria e coli superior control gentamicin gram posit bacteria aureus one compound r cf exhibit signific activ superior control gentamicin mic assay indic two compound h h biolog activ low concentr rang nano molar believ excel asset relat anticanc antibacteri activ make hybrid quinolin imidazolebenzimidazol compound bear phenyl group r c h para posit benzoyl moieti good candid futur drug develop | D000970;D001943;D003879;D007938;D011804 | T121;T109;T191 |
36,216,973 | metaphas cell enrich effici use dicentr chromosom assay dicentr chromosom assay dca consid gold standard radiat biodosimetri yet dca current implement may impract emerg respons applic especi time essenc owe labor intens time consum natur growth primari lymphocyt cultur h vitro requir dca manual score dicentr chromosom dcs requir addit h result overal process time h dose estim order improv time introduc protocol detect metaphas cell popul cell harvest metaphas cell metaphas enrich approach base fix human lymphocyt incub monoclon anti phosphoryl h histon ser antibodi histon shown specif mitot cell colcemid use arrest mitot cell metaphas follow flow cytometr sort apparatus isol mitot fraction larg popul cell minut mitot cell spread onto slide treat c band procedur gonen et al visual centromer dapi reduc chemic process time h reduc time requir dca make practic much wider set applic emerg respons follow exposur larg popul ioniz radiat | D002877;D011874 | T059;T026;T074;T073 |
36,216,966 | anti influenza combin therapi assess singl cell rna sequenc influenza make million peopl ill everi year place larg burden healthcar system economi develop treatment influenza combin virucid sialyl cyclodextrin interferon lambda demonstr human airway epithelia two compound inhibit replic clinic hn strain effici administ togeth rather alon investig mechan action combin treatment singl cell rna sequenc analysi found singl combin treatment impair viral replic differ extent across distinct epitheli cell type show cell type compris multipl sub type whose proport alter hn infect assess abil treatment restor best knowledg first studi investig effect antivir therapi influenza virus singl cell transcriptom studi | D003505;D053118;D007251 | T047;T109;T005;T130 |
36,216,965 | deep supervis atrous incept base u net combin crf automat liver segment ct due low contrast blur boundari liver tissu neighbor organ share similar intens valu problem liver segment ct imag yet achiev satisfactori perform remain challeng allevi problem introduc deep supervis ds atrous incept ai technolog condit random field crf propos three major improv experiment shown substant practic valu first replac encod standard convolut residu block residu block increas depth network second provid ai modul connect encod decod ai allow us obtain multi scale featur third incorpor ds mechan decod help make full use inform shallow layer addit employ tverski loss function balanc segment non segment region perform refin dens crf final extens valid propos method three public databas lit dircadb sliver compar state art method propos method achiev increas segment accuraci liver low contrast fuzzi boundari liver tissu neighbor organ therefor suit automat segment liver | D007091;D008099 | T023;T066 |
36,216,964 | metagenom dna sequenc quantifi mycobacterium tuberculosi dna diagnos tuberculosi tuberculosi tb remain signific caus mortal worldwid metagenom next generat sequenc potenti reveal biomark activ diseas identifi coinfect improv detect sputum scarc cultur negat case conduct larg scale compar studi plasma urin oral swab sampl individu tb endem non endem region evalu util shotgun metagenom dna sequenc assay tuberculosi diagnosi found composit control popul strong impact measur perform diagnost test use control popul compos individu tb non endem region led test near specif sensit wherea control group compos individu tb endem region exhibit high background nontubercul mycobacteri dna limit diagnost perform test use mathemat model quantit comparison match qpcr data found burden mycobacterium tuberculosi dna constitut small fraction less total abund dna origin mycobacteria sampl tb endem region find suggest util minim invas metagenom sequenc assay pulmonari tuberculosi diagnost limit low burden tuberculosi overwhelm biolog background nontubercul mycobacteri dna | D009169;D014376 | T007;T047 |
36,216,963 | enterotyp asthenospermia patient obes essenc enterotyp stratifi entir human gut microbiom modul associ diet diseas risk studi design center reproduct medicin shengj hospit china medic univers jinghua hospit shenyang prevotella bacteroid analyz sampl stool includ men enterotyp b normal overweightobes men enterotyp p normal overweightobes ratio prevotella bacteroid abund pb use simplifi way distinguish predomin enterotyp enterotyp p group pb obes risk factor reduc rate forward progress sperm motil odd ratio confid interv ci p reduc rate total sperm motil ci p obes also independ risk factor ci p adjust follicl stimul hormon enterotyp p bodi mass index diagnost indic reduc rate forward progress sperm motil decreas rate decreas total sperm motil auc valu p p respect signific higher predict valu patient howev enterotyp b group p obes risk factor asthenospermia signific differ obes sperm qualiti paramet observ studi tri introduc enterotyp popul base individu classif index investig correl bmi asthenospermia studi overweightobes men enterotyp p found poorer sperm qualiti howev sperm qualiti associ overweightobes men enterotyp b thereof bmi risk factor asthenospermia men enterotyp p men enterotyp b | D053627;D009765;D050177 | T047;T033 |
36,216,962 | bone miner densiti nutrient intak physic activ among young women uganda studi character bone miner densiti bmd among health young african women studi ugandan women age year found women healthi bmd lower averag standard refer rang refer rang avail bmd measur need greater precis | D015519;D002118 | T081;T121;T123;T196;T201 |
36,216,961 | efficaci covid higiv anim model sar cov infect late sever acut respiratori syndrom coronavirus sar cov virus emerg china quick spread worldwid pandem caus million hospit death despit use covid vaccin convalesc plasma monoclon antibodi emerg major therapeut option treatment covid develop anti sar cov immunoglobulin intraven human covid higiv potenti improv use convalesc plasma report efficaci covid higiv evalu hamster mous model sar cov infect covid higiv treatment mice hamster signific reduc viral load lung among covid higiv treat anim infect relat bodi weight loss reduc anim regain baselin bodi weight faster pbs control hamster covid higiv treatment reduc infect associ lung patholog includ lung inflamm pneumocyt hypertrophi lung result support ongo trial outpati treatment covid higiv safeti efficaci evalu nct nct | D000086382 | T047;T067 |
36,216,959 | integr use region weather forecast crop model water stress assess rice yield studi evalu effect water stress rice yield punjab haryana across north india integr weather research forecast wrf decis support system agrotechnolog transfer dssat model indian remot sens satellit dataset use defin land useland cover wrf accuraci simul rainfal temperatur punjab haryana evalu tropic rainfal measur mission autom weather station data indian space research organ respect data wrf use weather input dssat simul rice yield punjab haryana simul yield evalu district level observ yield water balanc compon within dssat model use analyz impact water stress rice yield correl r crop water stress factor rice yield anomali veget reproduct stage haryana punjab respect sever water stress flower matur stage inflict devast effect yield studi conclud region climat simul potenti use earli water stress predict impact rice yield | D012275 | T168;T002 |
36,216,958 | light seq light direct situ barcod biomolecul fix cell tissu spatial index sequenc present light seq approach multiplex spatial index intact biolog sampl use light direct dna barcod fix cell tissu follow ex situ sequenc light seq combin spatial target rapid photocrosslink dna barcod onto complementari dnas situ one step dna stitch reaction creat pool spatial index sequenc librari light direct barcod enabl situ select multipl cell popul intact fix tissu sampl full transcriptom sequenc base locat morpholog protein stain without cellular dissoci appli light seq mous retin section recov thousand differenti enrich transcript three cellular layer discov biomark rare neuron subtyp dopaminerg amacrin cell four eight individu cell per section light seq provid access workflow combin situ imag protein stain next generat sequenc cell leav sampl intact analysi post sequenc | D059014;D004247 | T059;T123;T063;T114 |
36,216,957 | irrelev angri face impair respons inhibit go stop process share attent resourc respons inhibit crucial compon execut control refer abil suppress respons longer need inappropri stop signal task standard tool assess inhibitori control action use irrelev facial express happi angri neutral go stop signal examin competit share attent resourc emot inhibit process b go stop process particip requir respond go signal gender discrimin task male femal occasion stop signal face irrelev angri happi neutral facial express present particip requir withhold motor respons found emot process especi angri face captur attent away task emot stop signal matter go signal non emot go signal non emot found stop signal irrelev angri facial express impair inhibitori control compar stop signal irrelev happi neutral facial express result indic process emot inhibit process exploit share pool attent resourc result favor interact capac share account go stop process model respons inhibit | D000786;D001288 | T041 |
36,216,956 | cholesterol stabil membran activ nanopor anticanc activ cholesterol enhanc pore format one evolutionari mean cholesterol free bacteri cell util specif target cholesterol rich eukaryot cell thus escap toxic membran lytic pore might brought onto present class artifici cholesterol depend nanopor manifest nanopor format sensit regul cholesterol mol relat lipid molecul high modular amphiphil molecular backbon enabl facil tune pore size consequ channel activ possess nano size caviti nm diamet activ channel ch c transport nanomet size molecul larg carboxyfluorescein display potent anticanc activ ic toward human hepatocellular carcinoma high select index valu normal human liver kidney cell respect | D058608 | T082 |
36,216,955 | inclus calcium phosphat improv vitro vivo osteogenesi novel high biocompat mechan stabl printabl polym time unpredict challeng health one trend certain exceed high demand function implant particular bone graft encourag emerg bone tissu engin substitut altern method convent bone graft howev current approach field face sever limit prevent ultim translat clinic set result mani attempt made fabric synthet bone implant offer suitabl biolog mechan propertieslight curabl methacryl base polym ideal properti bone repair materi also suitabl print applic restor function aesthet main object research investig role calcium phosphat cap incorpor mechan stabl biolog function printabl polym reconstruct complex craniofaci defect experiment work initi involv synthesi rarsar hexahydrofuro b furan diyl bis oxi bis ethan diyl bis oxi bis carbonyl bis azanediyl bis trimethylcyclohexan diyl bis azanediyl bis carbonyl bis oxi bis ethan diyl bis methylacryl refer csma fabric composit disc via digit light print dlp method flow behaviour polym function cap addit surfac remineralis potenti vitro cell cultur use mct adipos deriv mesenchym stem cell adsc ex ovo angiogen respons assess final vivo studi carri investig neo bone format week post implant quantit micro ct histolog evalu show higher rate bone format cap fill csma composit compar csma therefor polymer system hold promis featur allow flexibl design print scaffold target reconstruct maxillofaci defect | D018786;D010012 | T042;T122 |
36,216,953 | spectral interpret late stage mare basalt mineralog unveil chang e sampl western maria lunar near side wide cover late stage mare basalt due lack return sampl mineralog late stage basalt previous specul high abund olivin base remot sens observ howev show chang e ce lunar soil sampl ground truth past unsampl lunar late stage mare region give differ interpret laboratori spectroscop x ray diffract xrd analys ce soil sampl demonstr special spectral signatur repres iron rich high ca pyroxen rather olivin consid spectral composit similar ce soil sampl lunar late stage basalt mineralog petrolog ce sampl may abl general entir lunar late stage basalt studi would provid constraint thermal evolut moon especi young lunar volcan | D007501;D017640 | T121;T123;T197;T196 |
36,216,952 | acut chronic cardiometabol respons induc resist train blood flow restrict hiv patient resist train blood flow restrict rtbfr allow physic impair peopl live hiv pwh exercis lower intens tradit resist train trt acut chronic cardiac metabol respons pwh follow rtbfr protocol unknown object compar safeti acut chronic effect hemodynam lipid profil trt rtbfr pwh random control trial pwh alloc rtbfr g rtbfr n trt g trt n resist train protocol session week three time per week protocol intens g rtbfr g trt hemodynam heart rate blood pressur lipid profil acut rest post exercis th nd th session chronic pre post program record general linear model appli determin group time interact comparison group resist train program show acut adapt hemodynam respons differ p regardless assess session chronicl chang lipid profil favor g rtbfr signific lower level total cholesterol p triglycerid p ldl p compar g trt rtbfr trt induc similar hemodynam adapt pwh signific risk increas cardiovascular stress addit rtbfr promot better chronic adequaci lipid profil trt therefor rtbfr present safe resist train altern pwhtrial registr clinicaltrialsgov id nct date registr | D002318;D015658;D055070 | T061;T047 |
36,216,945 | two year effect semaglutid adult overweight obes step trial step trial assess efficaci safeti week subcutan semaglutid mg versus placebo plus behavior intervent long term treatment adult obes overweight least one weight relat comorbid without diabet co primari endpoint percentag chang bodi weight achiev weight loss week efficaci assess among random particip regardless treatment discontinu rescu intervent octob februari particip random assign semaglutid mg n placebo n complet trial attend end trial safeti visit particip femal white mean sd age year bodi mass index kg weight kg mean chang bodi weight baselin week semaglutid group n versus placebo n estim treatment differ point confid interv p particip semaglutid group placebo group achiev weight loss baselin week versus p gastrointestin advers event most mild moder report often semaglutid placebo versus summari adult overweight least one weight relat comorbid obes semaglutid treatment led substanti sustain weight loss week versus placebo nct | D003924;D050177 | T047;T033 |
36,216,942 | microbiom deriv ethanol nonalcohol fatti liver diseas test hypothesi gut microbiota individu nonalcohol fatti liver diseas nafld produc enough ethanol drive forc develop progress complex diseas perform one prospect clinic studi one intervent studi ethanol measur fast min mix meal test mmt individu subset individu extern valid cohort ethanol measur portal vein blood intervent studi ten individu nafld ten overweight otherwis healthi control infus select alcohol dehydrogenas adh inhibitor mmt compar fast peripher blood median portal vein ethanol concentr interquartil rang iqr time higher increas diseas progress mm individu without steatosi mm nafl mm nonalcohol steatohepat inhibit adh induc fold iqr fold increas peripher blood ethanol concentr individu nafld although effect abolish antibiot treatment specif lactobacillacea correl postprandi peripher ethanol concentr spearman rho p prospect studi data show first pass effect obscur level endogen ethanol product suggest microbi ethanol could consid pathogenesi high preval liver diseas | D064307;D065626 | T001;T047;T032;T028 |
36,216,941 | health effect associ smoke burden proof studi lead behavior risk factor numer health outcom smoke major ongo public health challeng although evid health effect smoke wide report attempt evalu dose respons relationship smoke divers rang health outcom systemat comprehens present studi estim dose respons relationship current smoke health outcom conduct systemat review may employ meta analyt method incorpor studi heterogen estim uncertainti among select outcom strong strong evid associ smoke weak moder evid associ evid associ overcom mani limit tradit meta analys approach provid comprehens date easi use estim evid health effect smoke estim provid import inform tobacco control advoc polici maker research physician smoker public | D012907;D016540 | T055 |
36,216,940 | health effect associ consumpt unprocess red meat burden proof studi character potenti health effect exposur risk factor red meat consumpt essenti inform health polici practic previous meta analys evalu effect red meat intak generat mix find formal assess evid strength conduct systemat review implement meta regress relax convent log linear assumpt incorpor studi heterogen evalu relationship unprocess red meat consumpt six potenti health outcom found weak evid associ unprocess red meat consumpt colorect cancer breast cancer type diabet ischem heart diseas moreov found evid associ unprocess red meat ischem stroke hemorrhag stroke also found risk six outcom analysi combin minim g unprocess red meat intak per day uncertainti interv incorpor studi heterogen wide g evid eat unprocess red meat associ increas risk diseas incid mortal weak insuffici make stronger conclus recommend rigor well power research need better understand quantifi relationship consumpt unprocess red meat chronic diseas | D003924;D000069466 | T047;T168 |
36,216,939 | global burden diseas studi year global burden diseas studi gbd began year ago goal provid time valid relev assess critic health outcom period gbd becom progress granular latest iter provid assess thousand outcom diseas injuri risk factor countri territori subnat level countri gbd produc activ collabor scientist analyst countri gbd iter data data process method use data synthesi evolv goal enhanc transpar compar measur communic various sourc uncertainti gbd mani limit remain dynam iter rigor attempt provid meaning health measur wide rang stakehold | D000071219;D014943 | T078;T091;T081 |
36,216,936 | health effect associ veget consumpt burden proof studi previous research suggest protect effect veget consumpt chronic diseas qualiti evid under find remain uncertain appli bayesian meta regress tool estim mean risk function quantifi qualiti evid associ veget consumpt ischem heart diseas ihd ischem stroke hemorrhag stroke type diabet esophag cancer increas veget consumpt theoret minimum risk exposur level g daili associ declin uncertainti interv includ studi heterogen ischem stroke risk declin ihd risk declin hemorrhag stroke risk declin esophag cancer risk declin type diabet risk found statist signific protect effect veget consumpt ischem stroke three star ihd two star hemorrhag stroke two star esophag cancer two star includ studi heterogen detect signific associ type diabet correspond one star rate although current evid support increas effort polici promot veget consumpt remain uncertainti suggest need continu research | D003924;D004938;D000083302;D000083242;D020521 | T191;T047 |
36,216,935 | burden proof studi assess evid risk exposur risk throughout life result wide varieti outcom object judg relat impact risk person popul health fundament individu surviv societ prosper exist mechan quantifi rank magnitud myriad effect uncertainti estim larg subject leav room interpret fuel academ controversi add confus communic risk present new suit meta analys term burden proof studi design specif help evalu methodolog issu object quantit data driven approach complement exist system includ grade cochran review aim aggreg evid across multipl studi enabl quantit comparison risk outcom pair introduc burden proof risk function bprf estim level risk closest null hypothesi consist avail data illustr bprf methodolog evalu four exemplar risk outcom pair smoke lung cancer systol blood pressur ischem heart diseas veget consumpt ischem heart diseas unprocess red meat consumpt ischem heart diseas strength evid relationship assess comput summar bprf translat summari simpl star rate burden proof methodolog provid consist way understand evalu summar evid risk across differ risk outcom pair inform risk analysi conduct part global burden diseas injuri risk factor studi | D017202;D012907 | T055;T047 |
36,216,934 | effect elev systol blood pressur ischem heart diseas burden proof studi high systol blood pressur sbp major risk factor ischem heart diseas ihd lead caus death worldwid use data publish observ studi control trial estim mean sbp ihd dose respons function burden proof risk function bprf calcul risk outcom score ros correspond star rate one five found strong signific harm effect sbp ihd mean risk relat mm hg sbp uncertainti interv includ studi heterogen mm hg mm hg mm hg conserv bprf measur indic sbp exposur mm hg rais risk averag yield ros star rate five analysi show ihd risk alreadi increas mm hg sbp rise steadili mm hg increas less steepli point studi endors need priorit strengthen strategi screen rais awar need time diagnosi treatment hypertens increas resourc alloc understand primordi prevent elev blood pressur | D006973;D017202 | T047 |
36,216,931 | anti tumor efficaci potent select non coval kras gd inhibitor recent progress target kras gc provid insight inspir target altern kras mutant studi evalu mechan action anti tumor efficaci mrtx potent select non coval kras gd inhibitor mrtx demonstr high affin interact gdp load kras gd k ic valu pm fold select compar kras wt cell line mrtx exhibit dose depend inhibit kras mediat signal transduct mark tumor regress subset kras gd mutant cell line deriv patient deriv xenograft model includ eight pancreat ductal adenocarcinoma pdac model pharmacolog crispr base screen demonstr co target kras gd putat feedback bypass pathway includ egfr pik led enhanc anti tumor activ togeth data indic feasibl select target kras mutant non coval high affin small molecul illustr therapeut suscept broad depend kras gd mutat posit tumor mutant kras tumor cell growth surviv | D021441;D010190 | T191 |
36,216,930 | atom model vesicular stomat virus mechan assembl like negat strand rna virus nsvs influenza rabi vesicular stomat virus vsv three layer organ layer matrix protein resid glycoprotein g stud membran envelop nucleocapsid compos nucleocapsid protein n encapsid genom rna lack situ atom structur viral compon limit mechanist understand assembl bullet shape virion cryoem sub particl reconstruct determin situ structur n insid vsv resolut virion n site stoichiometri situ structur n differ crystal structur n termin segment oligomer loop n rna n n n interact govern format capsid doubl layer contribut packag helic nucleocapsid inner im join neighbor turn n helix outer om contact g membran envelop pseudo crystallin organ g map cryoet mechan vsv assembl delin network interact viral compon | D054243 | T047 |
36,216,925 | dual sens signal decoupl base tellurium anisotropi vr interact neuro reflex system applic anisotropi control electron structur inorgan semiconductor import step develop devic endow multi function demonstr intrins anisotropi tellurium nanowir use modul electron structur piezoelectr polar decoupl pressur temperatur differ signal realiz vr interact neuro reflex applic architectur design devic combin self lock effect elimin depend displac enabl singl devic determin hard thermal conduct materi simpl touch use bimod te base sensor develop wearabl glove endow real object virtual world great improv vr somatosensori feedback addit success achiev stimulus recognit neural reflex rabbit sciatic nerv model integr sensor signal use deep learn techniqu view ex vivo feasibl bimod te base sensor would consid novel sens platform wide rang applic metavers ai robot electron medicin | D000076142;D000076251 | T066;T073 |
36,216,920 | rat use strategi make object choic spontan object recognit task rodent spontan object recognit sor paradigm wide use studi mechan complex memori mani laboratori due absenc explicit reinforc task under assumpt object exploratori behaviour spontan howev rodent strategis readili adapt behaviour depend current inform avail prior predic form learn memori use object place context episod like recognit task novel analyt method reli multipl trial within singl session demonstr rat use context base recenc base object recognit strategi type trial depend task condit exposur occasion ambigu condit chang anim respons toward recenc base prefer howev salient predict condit led anim explor object basi episod novelti reliant contextu inform result import implic futur research use sor task especi way experiment design analys interpret object recognit experi non human anim | D005106;D021641 | T055;T041 |
36,216,916 | identif biochem character novel n acetylglucosamin kinas saccharomyc cerevisia n acetylglucosamin glcnac key compon glycan glycoprotein cell wall glcnac kinas enzym transfer phosphat onto glcnac generat glcnac phosphat precursor glycan synthesi glcnac kinas found broad rang organ includ pathogen yeast human bacteria howev enzym never discov saccharomyc cerevisia eukaryot model studi first glcnac kinas cerevisia identifi name ngk k valu ngk glcnac glucos mm mm respect suggest ngk possess high affin glcnac unlik hexokinas ngk show glcnac phosphoryl activ various nucleosid triphosph name atp ctp gtp itp utp phosphoryl donor ngk phylogenet distant known enzym amino acid sequenc ident other less physiolog role ngk cerevisia also discuss | D000117;D017853;D012441 | T116;T121;T109;T126;T004 |
36,216,914 | condit context depend variat sexual dimorph across lizard popul differ spatial scale evolut sexual dimorph sd driven intric interplay sexual natur select come sd variat within popul howev environment factor play major role sexual select trait expect strong depend individu bodi condit influenc local environ individu experi consequ degre sd may also depend resourc avail investig potenti driver sd express two sexual dimorph morphometr trait bodi size snout vent length head shape head geometr morphometr italian wall lizard podarci siculus assess exist condit context depend sd across ten island aeolian archipelago southern itali within among popul scale observ strong geograph variat sd among island test three potenti sd predictor relat resourc avail individu bodi condit ecosystem product temperatur bodi condit ecosystem product main driver bodi size sd variat bodi condit also main driver head shape sd result highlight express sd italian wall lizard condit context depend result congruent within among popul scale highlight spatial multi scale analysi repres use approach understand pattern sd express | D008116 | T014 |
36,216,903 | isotop evid aestiv allow malaria mosquito persist dri season sahel data suggest malaria vector mosquito anophel coluzzii persist dri season sahel dormanc mechan known aestiv howev contribut aestiv compar altern strategi migrat unknown mark larval anophel mosquito two sahelian villag mali use deuterium h assess contribut aestiv persist mosquito seven month dri season initi enrich period coluzzii mosquito strong mark seven month follow enrich multipl analysi method support ongo presenc mark mosquito compat predict fraction mark mosquito remain stabl throughout dri season local aestiv occur result suggest aestiv major persist mechan coluzzii sahel contribut least adult onset rain persist strategi could influenc mosquito control malaria elimin campaign | D000852;D008288 | T047;T204 |
36,216,902 | influenc interrupt versus continu sutur techniqu intestin anastomot leakag rate patient crohn diseas propens score match analysi intestin anastomosi crucial step intestin resect anastomot leakag often associ sever consequ affect patient especi two differ techniqu hand sewn intestin anastomosi interrupt sutur techniqu ist continu sutur techniqu cst studi investig whether one two sutur techniqu associ lower rate anastomot leakag | D057868;D003424 | T047;T046 |
36,216,895 | compar studi multifunct irrig assist vacuum drainag vacuum seal drainag penros drain treat sever multi space deep fascial infect head neck aim compar multifunct irrig assist vacuum drainag mivd vacuum seal drainag vsd penros drain treat sever multi space deep fascial infect dfi head neck | D054843 | T061;T074 |
36,216,891 | pneumococc within host divers colon transmiss treatment character genet divers pathogen within host promis great improv surveil reconstruct transmiss chain bacteria also inform understand inter strain competit shape distribut resist sensit bacteria studi genet divers streptococcus pneumonia within infant mother deep sequenc whole pneumococc popul longitudin nasopharyng sampl demonstr deep sequenc unsurpass sensit detect multipl colon doubl rate high invas serotyp bacteria detect carriag compar gold standard method greater resolut identifi elev rate transmiss mother children first year child life comprehens treatment data demonstr infant elev risk acquisit persist colon multidrug resist bacterium follow antimicrobi treatment allel enrich antimicrobi treatment suggest aid persist general purifi select domin within host evolut rate co colon impli absenc treatment suscept lineag outcompet resist lineag within host result demonstr mani benefit deep sequenc genom surveil bacteri pathogen | D013296;D011008 | T007;T047 |
36,216,885 | quantit model reveal frequenc order predict predict error signal human brain human brain propos harbor hierarch predict code neuron network under percept cognit action support theori feedforward signal predict error report howev identif feedback predict signal elus due causal entangl predict error signal use quantit model decompos signal electroencephalographi auditori task identifi spatio spectral tempor signatur across two function hierarchi two predict signal identifi period prior sensori input low level signal repres tone tone transit high beta frequenc band high level signal multi tone sequenc structur low beta band subsequ predict error signal depend prior predict found gamma band find reveal frequenc order predict signal hierarch interact predict error signal support predict code theori | D001921;D004569 | T023;T060;T034 |
36,216,882 | use modifi line upper instrument vertebra select adolesc idiopath scoliosi lenk type curv valid system exist select upper instrument vertebra uiv optim postop shoulder balanc lenk type adolesc idiopath scoliosi ai studi evalu new method shoulder balanc predict use modifi shinshu line msl uiv select ai lenk type curv fifti five consecut ai patient receiv posterior spinal fusion psf lenk type ai curv retrospect analyz accord sever uiv determin model shoulder imbal judg absolut radiograph shoulder height mm year observ endpoint msl line center spinous process c lowest instrument vertebra vertebr bodi first touch proxim msl defin msl vertebra mslv recommend uiv group uiv match mslv signific lower preval shoulder imbal odd ratio ci p set mslv uiv psf ai lenk type may reduc preval postop shoulder imbal | D007738;D012600;D013123 | T061;T047;T190 |
36,216,875 | investig role common rare variant multiplex multipl sclerosi famili reveal increas burden common risk variat mani multipl sclerosi ms associ common risk variant well candid low frequenc rare variant identifi howev approxim half ms herit remain unexplain studi seven multiplex ms famili six parent consanguin identifi genet factor increas ms risk candid genom region identifi linkag analysi homozygos map fulli penetr rare low frequenc variant detect exom sequenc weight sum score polygen risk score prs analys conduct ms famili affect unaffect sporad ms case individu non ms control famili independ ancestri match control found famili ms case signific higher common risk variat burden compar popul control control famili sporad ms case tend higher prs compar famili ms case suggest presenc higher rare risk variat burden famili line score distribut among affect unaffect famili member within individu famili show known suscept allel explain diseas develop high risk multiplex famili other addit genet contributor increas ms risk | D009103 | T047 |
36,216,874 | cluster trauma patient base longitudin data applic machin learn predict recoveri predict recoveri trauma import provid patient perspect estim futur health engag share decis make target intervent relev patient group present studi sever unsupervis techniqu employ cluster patient base longitudin recoveri profil subsequ data driven cluster assess clinic valid expert use target supervis machin learn model present formalis analysi obtain cluster incorpor evalu statist machin learn metric ii cluster clinic valid descript statist medic expertis cluster qualiti assess reveal cluster obtain bayesian method high dimension supervis classif cluster deep gaussian mixtur model combin oversampl random forest supervis learn cluster assign provid among clinic sensibl partit patient method obtain higher classif accuraci suffer cluster solut larg major class clinic less sensibl class model use physic mix physic psycholog outcom prove among sensibl suggest cluster psycholog outcom alon yield recoveri profil conform known risk factor | D000069550;D000069553 | T066 |
36,216,870 | integr omic analysi pig muscl metabol effect dietari chlorella vulgari exogen enzym monogastr feed depend cost convent feedstuff microalga chlorella vulgari sustain altern howev recalcitr cell wall hinder monogastr digest carbohydr activ enzym cazym supplement possibl solut object work evalu effect dietari c vulgari cv enzymat supplement cv r rovabio excel ap cv four cazym mix muscl transcriptom proteom finish pig integr approach control pig increas abund contractil apparatus myh myh myh energi metabol ckmt nduf protein demonstr increas nutrient avail increas express scd characterist increas glucos avail via activ srebp c chrebp cv cv r pig upregul proteolyt apoptot gene bax dda whilst increas abund glucos uqcrf fatti acid catabol acad protein cv r pig upregul acot sirt gene respons reduc nutrient avail maintain energi homeostasi cell wall specif cazym mix cv abl compar reduc omic alter muscl therebi reduc endogen nutrient catabol compar cv r cv | D048408;D056566 | T126;T116;T002 |
36,216,863 | deconstruct drive factor land develop intens multi scale differenti function zone land develop intens ldi import indic much human exploit land resourc background rapid urban industri order curb occup agricultur ecolog space urban space china propos major function zone plan mfzp new spatial govern model attempt implement differenti ldi control accord function posit differ region observ spatio tempor evolut driver ldi first five year sinc implement mfzp chose yangtz river delta urban region china case area multi scale distribut pattern ldi analyz combin macro micro scale new spatial measur method integr global local regress model develop quantit deconstruct natur human driver ldi differ function zone result demonstr ldi decreas gradient urban zone uz main agricultur product zone mapz key ecolog function zone kefz uz ldi influenc natur human multi factor eg terrain condit slp proport cultiv land area pcl proport ecolog import area eid popul urban rate pur gdp per capita pgdp fix asset invest size per land fai fiscal expenditur percentag gdp fd ldi mapz main affect facilit role pcl eid fai promin role fd kefz main inhibit slp eid driven pgdp divers driver ldi differ function zone remind us implement differenti spatial control accord function posit adopt refin polici tool zone classif ensur land resourc within type function zone use sustain | D003247;D014507 | T068;T064;T081;T083;T069;T078 |
36,216,861 | n glycosyl cervicovagin fluid reflect microbi communiti immun activ pregnanc status human cervicovagin fluid cvf complex function import glycan rich biolog fluid fundament mediat physiolog event associ reproduct health use comprehens glycom strategi reveal extrem rich complex n glycom cvf pregnant non pregnant women abund paucimannos high mannos glycan complex glycan n acetyllactosamin lacnac antenna poli lacnac glycan decor fucosyl sialyl n glycosyl profil observ differ relat pregnanc status microbi composit immun activ pregnanc outcom compar cvf women experienc term birth cvf women subsequ experienc preterm birth show lower sialyl correl presenc divers microbiom higher fucosyl correl posit pro inflammatori cytokin concentr studi first step toward better understand role cervicovagin glycan reproduct health contribut mechan microbi driven preterm birth potenti prevent therapi | D064307;D047928 | T001;T046;T032;T028 |
36,216,859 | impact govern polici covid pandem unravel mathemat model sinc begin covid pandem control polici restrict hope contain rapid spread virus howev psycholog econom toll take societi entail necess develop optim control strategi assess effect intervent aid mathemat model remain non trivial issu term numer condit due high number paramet estim high noisi dataset signific correl polici time propos solut problem paramet non estim util data set european countri treat subset paramet common countri rest countri specif construct set individu model incorpor differ pandem control measur estim paramet without prior assumpt demonstr high predict abil model independ valid set rank polici effect reduc transmiss rate show rais awar inform campaign provid incom support close school workplac cancel public event maintain open test polici highest potenti mitig pandem | D000086382;D058873 | T047;T067 |
36,216,858 | analysi robust dynam spin lock prepar detect oscillatori magnet field extract quantit inform neuron signal non invas imag outstand challeng understand brain function patholog howev state art techniqu offer low sensit deep electr sourc stimulus induc rotari satur recent propos magnet reson imag sequenc detect oscillatori magnet field use spin lock prepar phantom experi simul prove effici sensit suscept method field inhomogen still well understood studi simul analyz dynam three spin lock prepar respons field inhomogen presenc reson oscil field show composit spin lock prepar robust field variat within doubl reson effect addit test capabl chosen composit spin lock prepar recov inform spectral compon composit signal studi set base move one step toward clinic applic mr base neuron current imag | D060526;D008279 | T059;T060;T170;T070 |
36,216,857 | associ neonat hyperbilirubinemia hypoglycemia chines women diabet pregnanc influenc factor retrospect studi aim investig correl neonat hyperbilirubinemia nhb hypoglycemia nh chines women diabet pregnanc dip influenc factor data collect juli june chines women dip live birth includ two separ multivari binari stepwis forward logist regress analysi calcul ci preval rate nhb nh respect among women dip comorbid diseas nh time like hyperbilirubinemia nhb posit correl nh increas gestat age protect effect nh nhb abnorm placent morpholog relat nh nhb regard neonat outcom congenit heart diseas chd risk factor nh nhb nhb nh signific correl women dip offspr dip multipl risk factor signific increas risk neonat hyperbilirubinemia | D016640;D051556;D007003;D011254 | T047 |
36,216,855 | intraven infus bone marrow deriv mesenchym stem cell improv tissu perfus rat hindlimb ischemia model intraven infus stem cell minim invas cellular deliveri method though report critic limb threaten ischemia clti anim model patient present studi hypothes intraven infus bone marrow deriv mesenchym stem cell mscs improv tissu perfus rat hindlimb ischemia model hindlimb ischemia generat spragu dawley rat femor arteri remov seven day ischem induct intraven infus mscs cell group vehicl control group perform compar control tissu perfus signific increas cell group histolog find show capillari densiti signific increas cell group infus green fluoresc protein gfp mscs distribut ischem limb furthermor gene express vascular endotheli growth factor vegf signific increas ischem hindlimb muscl tissu rat treat msc infus conclus intraven infus bone marrow deriv mscs improv tissu perfus ischem hindlimb angiogenesi suggest intraven infus mscs promis cell deliveri method treatment clti | D045164;D059630;D016491 | T061;T025;T047 |
36,216,854 | effect ivabradin cognit function rat scopolamin induc dementia alzheim diseas among challeng diseas social healthcar system treatment achiev yet although ambigu patholog mechan under disord ion channel dysfunct one recent accept possibl mechan hyperpolar activ cyclic nucleotid gate hcn channel play import role cellular excit synapt transmiss ivabradin iva hcn blocker act hcn channel clinic use angina arrhythmia current studi aim investig therapeut effect iva scopolamin sco induc dementia test hypothesi sco iva inject rat test behaviour chang follow elisa histopatholog analysi hippocampus induc dementia confirm behaviour test inflammatori cytokin oxid stress test histopatholog sign neurodegener multifoc deposit congo red stain amyloid beta plaqu decreas optic densiti hcn immunoreact iva amelior scopolamin induc dysfunct hippocampus restor normal healthi neuron amyloid plaqu disappear optic densiti hcn immunoreact increas hippocamp cell result suggest blockag hcn channel might under iva therapeut effect therefor iva might benefici effect neurolog disord link hcn channelopathi | D003704;D015221 | T123;T116;T048 |
36,216,852 | role incom govern respons reduc death toll flood indian state flood common occur natur disast india due india uniqu geograph locat socioeconom condit frequent flood caus enorm loss human live damag crop public util furthermor flood advers affect econom develop increas govern financi burden increas spend various disast mitig measur recent empir literatur base cross nation comparison show disast fatal damag monoton decreas per capita incom challeng view monoton negat relationship incom flood damag examin non monoton invert u shape relationship per capita incom flood impact term death peopl affect damag due flood major indian state use poisson tobit estim method particular death popul affect flood increas turn point incom us us respect diminish thereaft result confirm invert u shape relationship incom fatal popul affect flood addit incom argu govern respons play essenti role mitig risk flood employ fix effect poisson estim method examin govern role protect peopl disast risk focus region differ india death flood remain non linear follow invert u pattern respect govern respons howev effect govern respons flood fatal flood damag statist insignific result suggest high incom state experi lower death toll flood high incom rich state capabl incur higher threshold level incom higher natur calam expenditur reduc flood fatal protect popul affect flood low incom poor state poor state minim resourc face sever financi constraint reduc death toll flood perspect public polici poor state particular requir increas incom better govern effect disast manag polici mitig flood impact | D004190;D000077587 | T067;T070 |
36,216,851 | activ tactil sens small insect forc soft microfing toward microfing insect interact human robot interact technolog contribut improv social humanoid robot scale far human scale microrobot interact environ small world microsensor appli measur forc fli walk insect meanwhil previous work focus measur behavior insect propos microrobot insect interact soft microfing integr artifici muscl actuat tactil sensor develop haptic teleoper robot system soft pneumat balloon actuat act artifici muscl flexibl strain sensor use liquid metal provid tactil sens forc interact pill bug microfing could accomplish microfing mm mm move touch insect detect reaction forc insect measur reaction forc leg pill bug repres insect less mn paper present microfing end effector activ sens reaction forc small insect anticip result lead evalu small live thing well technolog develop human environ interact | D012371;D055698 | T090;T041 |
36,216,850 | feasibl apoc serum level tumor biomark glioblastoma patient pilot studi apolipoprotein c apoc detect immunohistochem glioblastoma tissu probabl express activ monocyt microglia present studi conceiv determin whether amount intratumor apoc express lead measur chang serum level glioblastoma resect recurr blood sampl glioblastoma patient collect periop subsequ therapi apoc serum level determin use enzym link immunosorb assay elisa high absorpt valu due lipem hemolyt serum remov final dataset use stem leaf plot sampl group accord treatment stage compar mean apoc serum level number patient fall increas periop valu assess apoc serum valu glioblastoma patient amen statist evalu mean apoc serum level gml n sd sampl patient undergo first glioblastoma resect mean preoper valu signific higher gml n sd surgeri gml n sd p individu fall apoc level detect rise level patient p singl absolut serum level apoc allow estim glioblastoma activ tumor respons although pathophysiolog interest apoc serum level qualifi potenti biomark glioblastoma manag result seem encourag larger multicent studi | D053302;D005909 | T191;T123;T116 |
36,216,849 | first high densiti genet map common cockl cerastoderma edul reveal major qtl control shell color variat shell color show broad variat within mollusc speci despit inform genet pathway involv shell construct color recent increas studi need understand genet architectur common cockl cerastoderma edul valuabl speci ecolog commerci perspect show import variat shell color across northeast atlant studi construct high densiti genet map tool screen common cockl genom appli ascertain genet basi color variat speci consensus genet map compris linkag group lgs accord cockl karyotyp n span cm includ marker per lg inter marker distanc cm five full sib famili show segreg sever color associ trait use genom wide associ studi major qtl chromosom associ differ color trait detect mine genom region reveal sever candid gene relat shell construct color genom region previous report associ diverg select cockl distribut overlap qtl suggest putat role adapt | D060105;D049873;D003116;D040641 | T028;T023;T080;T204 |
36,216,848 | role klebsiella pneumonia type vi secret system tss long term gastrointestin colon type vi secret system tss recent describ hypervirul k pneumonia hvkp strain involv bacteri warfar role classic clinic strain ckp littl investig silico analysi indic presenc tss cluster zero four irrespect strain origin virul high preval k pneumonia speci strain ch two tss appar pathogen island detect tss harbor phospholipas encod gene tle potenti new effector encod gene name tke type vi klebsiella effector tle express escherichia coli periplasm affect cell membran permeabl tss isogen mutant colon highest gastrointestin tract mice less effici parent strain long term compar analysi faecal sequenc indic tss impair microbiota rich resili capac oscillospiracea famili member could specif competitor long term gut establish k pneumonia | D000069376;D000069377 | T116 |
36,216,846 | contrast enhanc locat volum associ long term outcom thrombectomi acut ischem stroke contrast enhanc ce brain non contrast comput tomographi ncct common endovascular thrombectomi evt patient acut ischem stroke ai associ clinic outcom well establish current studi aim investig relationship retrospect review consecut patient acut ischem stroke hyperdens ncct immedi evt anterior circul larg vessel occlus lvo januari decemb use aspect combin volum measur reconstruct estim extent locat ce multivari regress analysi conduct explor risk factor associ clinic outcom studi anterior circul ai lvo patient hyperdens brain ncct strict inclus exclus criteria total patient enrol final analysi logist regress analysi ce aspect ce volum ce caudat nucleus region associ month poor function outcom adjust confound factor convent variabl model use refer includ age initi nihss procedur time stent retriev pass recan status baselin aspect auc combin name variabl convent variabl ce aspect ce volum ce caudat nucleus ce region ce region predict power signific improv auc ci spatial locat volum ce ncct obtain immedi evt independ strong predictor poor outcom month patient ai exclud definit hemorrhag h follow ct | D002545;D057510;D000083242;D020521 | T061;T047;T046 |
36,216,844 | clinicopatholog characterist prognost analysi monoclon gammopathi renal signific mgrs patient igm monoclon gammopathi case seri monoclon gammopathi emerg import caus renal injuri sinc clinicopatholog featur relat monotyp monoclon gammopathi renal signific igm monoclon gammopathi igm mgrs poor describ uncertain intervent improv renal surviv mortal report seri patient character clinicopatholog spectrum outcom retrospect analyz patient refer one medic center detect serum monoclon igm immunofix perform bone marrow biopsi kidney biopsi proven mgrs patient identifi half patient amyloidosi follow cryoglobulinem glomerulonephr patient divid two group basi kidney patholog amyloid non amyloid patient non amyloidosi like renal dysfunct hematuria anemia hypocomplementemia light chain predomin sub group amyloid patient often treat chemotherapi non amyloid patient p signific differ amyloid non amyloid patient mortal vs p incid esrd vs p incid esrd lower patient treat chemotherapi andor asct compar without chemotherapi vs p also lower hematolog respond non respond vs p studi confirm divers varieti clinicopatholog featur outcom patient igm mgrs chemotherapi andor asct deep hematolog respons might improv renal prognosi | D000686;D007674;D007676;D016393;D008998;D010265 | T191;T047 |
36,216,842 | african america studi demonstr subclin cardiovascular risk differ etiolog abnorm glucos toler abnorm glucos toler abnl gt due imbal cell function insulin resist ir major risk factor cardiovascular diseas cvd sub saharan africa cell failur emerg import caus abnl gt abnl gt cell failur viscer adipos tissu vat volum hyperlipidemia major contributor cvd risk abnl gt due ir abnl gt ir yet cvd profil associ abnl gt cell failur unknown therefor goal african born black male age year bmi kgm live america determin abnl gt preval etiolog assess abnl gt etiolog associ four understudi subclin cvd risk factor african subclin myocardi damag high sensit troponin hs ctnt b neurohormon regul n termin pro brain natriuret peptid nt probnp c coagul fibrinogen inflamm high sensit c reactiv protein hscrp well hba c cholesterolhdl ratio vat glucos toler status determin ogtt ir defin threshold lowest quartil matsuda index abnl gt ir requir abnl gt ir abnl gt cell failur defin abnl gt without ir vat assess ct scan abnl gt cell failur abnl gt ir group four multipl regress model perform hs ctnt nt probnp fibrinogen hscrp depend variabl remain three biomark hba c cholesterolhdl vat independ variabl abnl gt occur abnl gt group cell failur occur ir vat cholesterolhdl signific lower abnl gt cell failur group vs abnl gt ir group p abnl gt cell failur group signific associ exist hsctnt fibrinogen hs crp hba c p none cholesterolhdl vat abnl gt ir hs ctnt fibrinogen hscrp signific associ cholesterolhdl p nt probnp invers relat fibrinogen hscrp hba c cholesterolhdl vat p subclin cvd risk profil differ abnl gt cell failur abnl gt ir abnl gt cell failur subclin cvd risk involv subclin myocardi damag hypercoagul increas inflamm hyperlipidemia viscer adipos abnl gt ir subclin cvd risk relat subclin myocardi damag neurohormon dysregul inflamm associ hyperlipidemia viscer adipos clinicaltrialsgov identifi nct | D002318;D007333 | T047;T046 |
36,216,841 | structur insight pa mediat inactiv pseudomona aeruginosa plda plda phospholipas pld effector catalyz hydrolysi phosphodiest bond glycerophospholipid main compon cell membran assist invas opportunist pathogen pseudomona aeruginosa cognat immun protein pa inhibit activ plda avoid self toxic howev precis inhibitori mechan remain elus determin crystal structur full length truncat plda cryogen electron microscopi structur plda pa complex structur analysi reveal differ intermedi plda open close state catalyt pocket accompani signific conform chang lid region peripher helic domain structur base mutat analysi identifi key residu respons enzymat activ plda togeth data provid insight molecular mechan plda invas neutral pa aid futur design pld target inhibitor drug | D010739;D011550 | T007;T126;T116 |
36,216,840 | race ethnic moder associ lifetim psychedel use mdma psilocybin psycholog distress suicid psychedel compound link salutari mental health outcom naturalist clinic set howev current research psychedel suffer lack inclus focus racial ethnic minor thus goal studi assess whether race ethnic moder associ naturalist lifetim mdma methylenedioxymethamphetamin use psilocybin use share past month psycholog distress past year suicid ideat plan use data nation survey drug use health nsduh n conduct survey weight multivari logist regress conduct interact test assess associ mdma use psilocybin use share aforement outcom racial ethnic group race ethnic signific moder associ mdma psilocybin use psycholog distress suicid white particip mdma psilocybin use confer lower odd distress suicid outcom racial ethnic minor particip associ psychedel use suicid far fewer find invit research impact race ethnic ident factor eg socioeconom status sexualgend minor status effect psychedel substanc | D006213;D018817;D000079225;D013405 | T131;T121;T109;T048;T033 |
36,216,838 | spatio tempor metabol rewir brain tgf ad rat model alzheim diseas brain damag associ alzheim diseas ad occur even decad symptomat onset rais need investig progress prodrom stage context anim model progress display ad patholog hallmark eg tgf ad becom crucial translat technolog magnet reson spectroscopi mrs enabl longitudin metabol character diseas howev integr approach requir unravel complex metabol chang under ad progress earli advanc stage tgf ad wild type wt rat studi vivo tesla mri scanner longitudin quantit assess brain metabol profil chang use mrs diseas progress investig time point month age region cortex hippocampus striatum thalamus compar wt tgf ad rat replic common find ad patient includ decreas n acetylaspart cortex hippocampus thalamus decreas glutam thalamus striatum differ longitudin evolut metabol concentr observ tgf ad wt group name age depend trajectori differ group creatin cortex thalamus taurin cortex signific decreas tg ad anim wherea myo inositol thalamus striatum show greater increas along time wt group addit analysi reveal diverg intra inter region metabol coupl group thus cortex strong coupl n acetylaspart creatin myo inositol wt taurin tgf ad rat observ wherea hippocampus myo inositol taurin cholin compound level high correl wt tgf ad anim furthermor specif cortex hippocampus striatum metabol crosstalk found taurin level wt group myo inositol level tgf ad rat system biolog perspect metabol chang ad patholog result shed light complex spatio tempor metabol rewir diseas report first time age tissu depend imbal myo inositol taurin metabolit creatin unveil role diseas progress point inadequaci latter intern refer quantif | D000544 | T047;T048 |
36,216,837 | scleral perk atf target myopic axial elong mous eye axial length primari determin eye size elong myopia howev under mechan onset progress axial elong remain unclear show endoplasm reticulum er stress sclera essenti regul axial elong myopia develop activ perk atf axi follow scleral collagen remodel mice len induc myopia lim show er stress sclera pharmacolog intervent er stress could induc inhibit myopia progress lim activ ire perk atf axi pharmacolog inhibit perk atf suppress myopia progress confirm knock two gene via crisprca system lim dramat chang express scleral collagen gene respons er stress furthermor collagen fiber thin express dysregul collagen lim amelior pba administr demonstr scleral er stress perkatf pathway control axial elong myopia develop vivo model pba eye drop promis drug myopia suppressiontreat | D051702;D009216;D012590;D019892 | T047;T023;T116;T126;T123 |
36,216,836 | one click devic rapid visual extract latent evid multi mode light sourc integr light guid technolog visual latent evid crime scene gain popular field forens scienc past year thus studi design develop one click devic rapid visual extract latent evid multimod light sourc integr light guid technolog devic exhibit multispectr angl time function store captur evid imag furthermor geometr registr featur extract featur optim featur integr evid imag process backend system imag present overal studi enhanc standard technic content evid extract simplifi evid extract process addit rapid handl scene captur crime scene one click devic notabl advantag fast imag portabl independ environment condit oper technic capabl zero pollut ensur repeat materi evid extract compar origin optic forens equip spectrum angl system extens | D003415;D044707 | T054;T090;T068 |
36,216,834 | epiderm growth factor receptor cascad priorit maxim signal transduct mani studi perform quantifi cell signal cell signal molecul phosphoryl respons extracellular stimuli phosphoryl sequenc form signal cascad inform gain signal event given logarithm phosphoryl molecul ratio averag inform gain regard signal transduct quantiti st ident kullback leibler diverg kld relat entropi previous report total st valu given signal cascad maxim st rate str signal molecul per signal durat min approach constant valu experiment verifi theoret conclus measur str epiderm growth factor egf relat cascad skin cancer cell follow stimul egf use antibodi microarray phosphoryl signal molecul result consist theoret analysi thus signal transduct system may adopt strategi priorit maxim st furthermor signal molecul similar strs may form signal cascad conclus st str promis properti quantit analysi signal transduct | D004815;D066246 | T116;T192;T121;T126;T125 |
36,216,833 | deforest intensifi daili temperatur variabl northern extratrop biogeophys effect deforest averag extrem temperatur broad document deforest influenc temperatur variabl remain larg unknown fill knowledg gap investig biogeophys effect ideal deforest daili temperatur variabl global scale base multipl earth system model situ observ show deforest intensifi daili temperatur variabl northern extratrop particular winter lead frequent rapid extrem warm cool event higher temperatur variabl attribut enhanc near surfac horizont temperatur advect simultan part offset lower variabl surfac sensibl heat flux also show respons daili temperatur variabl histor deforest futur potenti afforest studi reveal overlook effect deforest afforest temperatur variabl implic larg scale afforest northern extratrop countri | D003247 | T069;T064;T081;T078 |
36,216,831 | elucid tumor heterogen spatial resolv transcriptom data multi view graph collabor learn spatial resolv transcriptom srt technolog enabl us gain novel insight tissu architectur cell develop especi tumor howev lack comput exploit biolog context multi view featur sever hinder elucid tissu heterogen propos stmvc multi view graph collabor learn model integr histolog gene express spatial locat biolog context analyz srt data attent specif stmvc adopt semi supervis graph attent autoencod separ learn view specif represent histolog similar graph spatial locat graph simultan integr two view graph robust represent attent semi supervis biolog context stmvc outperform tool detect tissu structur infer trajectori relationship denois benchmark slice human cortex particular stmvc identifi diseas relat cell state transit cell state breast cancer studi valid function surviv analysi independ clinic data result demonstr clinic prognost applic srt data | D001943;D000073919 | T191;T065 |
36,216,827 | molecular character renal cell carcinoma tumor phase iii anti angiogen adjuv therapi trial multigen assay provid insight key biolog process prognost inform guid develop select adjuv cancer therapi report comprehens genom transcriptom analysi tumor sampl patient high risk recurr renal cell carcinoma post nephrectomi trac trial nct identifi gene express signatur includ strac deriv sunitinib treat popul overlap key element captur gene express signatur includ gene repres tumor stroma microenviron regulatori cell myeloid cell suggest like prognost predict anti angiogen effect adjuv set signatur also point identif potenti therapeut target develop adjuv renal cell carcinoma mertk tdo final find suggest anti angiogen adjuv therapi might import may suffici prevent recurr factor immun respons tumor environ may greater import | D002292;D007680 | T191 |
36,216,822 | isg conjug protein nascent dna mitig dna replic stress pathway involv suppress dna replic stress associ dna damag critic maintain genom integr mre complex uniqu among doubl strand break dsb repair protein associ dna replic fork show mre complex inactiv caus dna replic stress chang abund protein associ nascent dna one high enrich protein dna replic fork upon mre complex inactiv ubiquitin like protein isg mre complex defici drug induc replic stress led accumul cytoplasm dna subsequ activ innat immun signal via cgas sting tbk led isg induct protein isgyl includ constitu replic fork isg play direct role prevent replic stress delet isg associ replic fork stall tonic atr activ genom aberr sensit aphidicolin data reveal previous unrecogn role isg mitig dna replic stress promot genom stabil | D004260;D004261 | T045 |
36,216,821 | allel specif differenti regul monoallel express autosom gene cardiac lineag mammalian autosom gene repres two allel diploid cell knowledg insight made regard allel specif regulatori mechan autosom use allel specif singl cell transcriptom analysi elucid establish monoallel gene express cardiac lineag find monoallel express autosom gene mesc mous blastocyst cell differenti regul base genet background parent allel howev genet background allel affect establish monoallel gene differenti cardiomyocyt addit observ epigenet differ determinist random autosom monoallel gene moreov also find greater contribut matern versus patern allel develop homeostasi cardiac tissu cardiac health highlight import matern influenc male cardiac tissu homeostasi find emphas signific allel specif insight gene regul develop homeostasi diseas | D002875;D044127 | T026;T045 |
36,216,820 | old drug new trick leverag known compound disrupt coronavirus induc cytokin storm major complic covid infect consist onset acut respiratori distress fuel dysregul host immun network lead run away cytokin storm present silico approach captur host immun system complex regulatori dynam allow us identifi rank candid drug drug pair engag minim subset immun mediat downstream interact effect disrupt signal cascad drive cytokin storm drug target regulatori interact extract peer review literatur use autom text mine compound associ covid induc cytokin storm element under biolog target mode action compound well combin compound score function align set compet model predict optim intervent strategi well avail like act compound known target effect top rank individu compound identifi includ number known immun suppressor calcineurin mtor inhibitor well compound less frequent associ immun modulatori effect includ antimicrobi statin cholinerg agonist pairwis combin drug target distinct biolog pathway tend perform signific better singl drug dexamethason emerg frequent high rank companion predict drug combin aim disrupt covid induc acut respiratori distress syndrom approach appli broad diseas may provid standard tool drug discoveri initi evalu altern target repurpos approv drug | D000086382;D019161 | T121;T047;T109;T067 |
36,216,817 | structur basi specif inhibit deubiquitinas uchl ubiquitin regul protein homeostasi tight control deubiquitinas dub loss dub uchl lead neurodegener dysregul promot cancer metastasi invas small molecul probe uchl dub general could help investig function yet specif inhibitor structur inform rare report potent non toxic chemogenom pair activ base probe gks gks uchl biochem character gks demonstr stereoselect inhibit cellular uchl crystal structur uchl complex gks show enzym lock hybrid conform apo ubiquitin bound state under uchl specif within uch dub famili phenocopi report inactiv mutat uchl mice gks gks lead reduc level monoubiquitin human glioblastoma cell line collect introduc set structur character chemogenom probe suitabl cellular investig uchl | D025801;D043222 | T126;T123;T116 |
36,216,816 | infer differenti subcellular localis compar spatial proteom use bandl steadi state localis protein provid vital insight function localis context specif protein transloc differ subcellular nich upon perturb subcellular environ differenti localis chang steadi state subcellular locat protein provid step toward mechanist insight subcellular protein dynam high accuraci high throughput mass spectrometri base method exist map steadi state localis localis protein describ principl bayesian approach bandl use data comput probabl protein differenti localis upon cellular perturb extens simul studi demonstr bandl reduc number type type ii error compar exist approach applic bandl sever dataset recov well studi transloc applic cytomegalovirus infect obtain insight rewir host proteom integr high throughput dataset allow us provid function context data | D020543;D040901 | T091;T123;T116 |
36,216,814 | combin plasma membran sterol biosynthesi autophagi requir shade induc hypocotyl elong plant growth ultim depend fix carbon thus avail light photosynthesi due canopi light absorpt properti veget shade combin low blue lb light low red far red ratio lrfr shade avoid plant two condit independ trigger growth adapt enhanc light access howev condit differ light qualiti quantiti similar promot hypocotyl growth remain unknown use rna sequenc show two featur shade trigger differ transcript reprogram lb induc starvat respons suggest switch catabol state accord lb promot autophagi contrast lrfr induc anabol includ express sterol biosynthesi gene hypocotyl manner depend phytochrom interact factor pif genet analys show combin sterol biosynthesi autophagi essenti hypocotyl growth promot veget shade propos veget shade enhanc hypocotyl growth combin autophagi mediat recycl promot specif lipid biosynthet process | D017360;D029681;D010834 | T123;T116;T002 |
36,216,812 | train recurr neural network generat neural network molecular structur impact drug discoveri deep learn approach becom popular recent year de novo drug design generat model molecul generat optim shown promis result molecul train differ chemic data could regener molecul similar queri molecul thus support lead optim recurr neural network base generat model demonstr applic low data drug discoveri fragment base drug design lead optim | D016571;D055808 | T170;T062 |
36,216,811 | nrsfrest lie intersect epigenet regul mirna mediat gene control neurodevelopment pathway associ intellectu disabl id schizophrenia genet evid indic disrupt epigenet regul major risk factor psychiatr disord molecular mechan drive associ remain determin ehmt epigenet repressor causal kleefstra syndrom ks genet disord link neurodevelopment disord associ schizophrenia show reduc ehmt activ decreas nrsfrest protein lead abnorm neuron gene express progress neurodevelop human ipsc show ehmt regul nrsfrest indirect via repress mirna lead aberr neuron gene regul neurodevelop time express nrsfrest mrna lack mirna bind site restor neuron gene regul ehmt defici cell signific ehmt regul mirna gene set control nrsfrest enrich associ intellectu disabl id schizophrenia reveal broad molecular interact hk demethyl nsrfrest regul risk id schizophrenia | D008607;D035683;D012097;D012559 | T123;T116;T048;T114 |
36,216,809 | ift k cell function stemprogenitor cell salivari gland stemprogenitor cell import salivari gland develop homeostasi mainten regener follow injuri keratin k cell recogn bona fide salivari gland stemprogenitor cell howev k also express termin differenti myoepitheli cell therefor accur molecular marker identifi salivari stemprogenitor cell requir intraflagellar transport ift protein ift core compon ift system function signal transduct primari cilia report express mesenchym stem cell play role bone format studi demonstr ift intens express k stemprogenitor cell development period earli regener stage follow ligat induc injuri murin submandibular gland addit demonstr ift k could self renew differenti granular duct cell development stage vivo condit delet ift k cell caus abnorm epitheli structur function salivari gland develop inhibit regener ift part coordin function k stemprogenitor cell modul ciliari membran traffick investig identifi combin marker ift k salivari gland stemprogenitor cell elucid essenti role ift cilia regul salivari stemprogenitor cell differenti gland regener | D012469;D013234 | T023;T025;T081 |
36,216,808 | membran assist assembl select secretori autophagi enterovirus enterovirus non envelop posit sens rna virus caus divers diseas human rapid multipl depend remodel cytoplasm membran viral genom replic unknown virion assembl around newli synthes genom load autophag membran releas secretori autophagi use cryo electron tomographi infect cell show poliovirus assembl direct replic membran pharmacolog unteth capsid membran abrog rna encapsid data direct visual membran bound half capsid promin virion assembl intermedi assembl progress past intermedi depend class iii phosphatidylinositol kinas vps key host cell autophagi factor hand canon autophagi initi ulk shown restrict virion product sinc inhibit lead increas accumul virion vast intracellular array follow increas vesicular releas later time point final identifi multipl layer select virus induc autophagi strong select rna load virion empti capsid segreg virion type autophagosom content find provid integr structur framework multipl stage poliovirus life cycl | D004769;D017955 | T047;T005 |
36,216,807 | prenat ethanol exposur caus anxieti like phenotyp alter synapt nitric oxid endocannabinoid signal dorsal raph nucleus adult male rat mood disord includ anxieti depress caus prenat ethanol exposur pe preval condit fetal alcohol spectrum disord fasd prenat ethanol exposur associ persist dysfunct sever neurotransmitt system includ serotonin ht system play major role mood regul stress homeostasi pe known disrupt develop ht system cellular mechan alter function dorsal raph nucleus drn ht neuron synapt input remain unknown use second trimest bing drink pattern pe two daili gavag wv ethanol gkg h apart gestat day measur anxieti like behavior adult male rat use elev plus epm zero zm maze also employ ex vivo electrophysiolog pharmacolog approach unravel mechan pe alter excit synapt transmiss onto drn ht neuron found pe enhanc anxieti like behavior adult male rat induc persist activ drn ht neuron pe induc activ drn ht neuron larg mediat potenti drn glutam synaps caus activ nitrerg system impair endocannabinoid signal present studi reveal push pull effect pe nitrerg ecb signal respect mediat enhanc activ drn ht neuron could contribut anxieti like behavior observ anim model fasd | D065847;D012701 | T023;T109;T123 |
36,216,803 | visual inflamm macrophag select probe via glut gate target macrophag play crucial role protect bodi infect cancer macrophag multi function immun cell divers plastic subset deriv nave cell subset specif macrophag probe essenti deciph monitor various activ macrophag develop probe challeng report fluoresc probe cdr select macrophag select stain mechan cdr explic gate orient live cell distinct gold overexpress glut macrophag final demonstr suitabl cdr track macrophag vivo rheumatoid arthriti anim model | D005456;D008264 | T025;T130 |
36,216,802 | metasurfac driven full space structur light three dimension imag structur light sl base depth sens technolog illumin object array dot backscatt light monitor extract three dimension inform convent diffract optic element use form laser dot array howev field view fov diffract effici limit due micron scale pixel size propos metasurfac enhanc sl base depth sens platform scatter high densiti k dot array fov manipul light subwavelength scale proof concept place face mask one beam axi apart axi within distanc estim depth inform use stereo match algorithm furthermor demonstr replic metasurfac use nanoparticl embed resin nano per imprint method enabl high throughput manufactur metasurfac arbitrari substrat full space diffract metasurfac may afford ultra compact depth percept platform face recognit automot robot vision applic | D021621;D012107 | T073;T060;T081;T170;T169;T062;T096 |
36,216,801 | stem cell microencapsul maintain stem inflammatori microenviron maintain stem transplant stem cell spheroid inflammatori microenviron challeng import regen medicin direct deliveri stem cell repair periodont defect may yield suboptim effect due complex periodont inflammatori environ herein stem cell spheroid encapsul interfaci assembl metal phenol network mpn nanofilm form stem cell microspher capsul specif periodont ligament stem cell pdlscs spheroid coat fe iii tannic acid coordin network obtain spheroid fe iii ta microcapsul form biodegrad mpn biointerfac act cytoprotect barrier exhibit antioxid antibacteri anti inflammatori activ effect remodel inflammatori microenviron maintain stem pdlscs stem cell microencapsul propos studi appli multipl stem cell various function metal ionpolyphenol coordin provid simpl yet effici deliveri strategi stem cell stem mainten inflammatori environ toward better therapeut outcom | D000079585;D059808 | T059;T109;T121 |
36,216,800 | age link suppress lipoxin associ cognit deficit mice human age increas risk cognit impair singl major risk factor alzheim diseas ad preval form dementia elder pathophysiolog process trigger age render brain vulner dementia involv least part chang inflammatori mediat show lipoxin lxa lipid mediat inflamm resolut known stimul endocannabinoid signal brain reduc age central nervous system demonstr genet suppress lipoxygenas lox enzym mediat lxa synthesi promot learn impair mice convers administr exogen lxa attenu cytokin product memori loss induc inflamm mice show cerebrospin fluid lxa reduc patient dementia posit associ cognit perform brain deriv neurotroph factor bdnf ad link amyloid find suggest reduc lxa level may lead vulner age relat cognit disord promot lxa signal may compris effect strategi prevent earli cognit declin ad | D000544;D060825;D044045 | T047;T109;T123;T048 |
36,216,799 | spatial transcriptom landscap non small cell lung cancer brain metastasi brain metastas brms common occurr lung cancer dismal outcom understand mechan metastasi inform prognosi treatment analyz primari metastas tumor specimen non small cell lung cancer patient spatial rna sequenc afford whole transcriptom map metastasi resolv morpholog marker tumor core tumor immun microenviron time tumor brain microenviron tbme data indic tumor microenviron tme brain includ time tbme undergo extens remodel creat immunosuppress fibrogen nich brms specif brain tme character reduc antigen present bt cell function increas neutrophil type macrophag immatur microglia reactiv astrocyt differenti gene express network analysi identifi fibrosi immun regul major function modul disrupt lung brain tme besid provid system level insight mechan lung cancer brain metastasi studi uncov potenti prognost biomark suggest therapeut strategi tailor immun fibrosi status brms | D001932;D002289;D008175 | T191 |
36,216,795 | select oral bioavail vhl recruit protac achiev smarca degrad vivo target protein degrad offer altern modal classic inhibit hold promis address previous undrugg target provid novel therapeut option patient heterobifunct molecul co recruit target protein e ligas result ubiquityl proteosom depend degrad target clinic oral rout administr option choic achiev far crbn recruit bifunct degrad molecul aim achiev oral bioavail molecul select degrad baf chromatin remodel complex atpas smarca close relat paralogu smarca allow vivo evalu synthet lethal concept smarca depend smarca defici cancer outlin structur properti guid approach led oral bioavail vhl recruit degrad tool compound acbi show select degrad smarca smarca ex vivo human whole blood assay vivo efficaci smarca defici cancer model studi demonstr feasibl broaden e ligas physicochem space utilis achiev oral efficaci bifunct molecul | D000251;D014157 | T126;T116;T123 |
36,216,794 | ni catalyz carbamoyl unactiv alken stereoselect construct six member lactam nitrogen base heterocycl arous widespread interest due reoccurr mani pharmaceut amongst motif enantioenrich lactam ubiquit scaffold found myriad biolog activ natur product drug recent transit metal catalyz asymmetr carbamoyl wide employ straightforward arsenal chiral lactam architectur synthesi includ lactam lactam howev despit extens effort still remain protocol accomplish relat lactam synthesi manuscript ni catalyz enantioselect carbamoyl unactiv alken leverag reduct dicarbofunction strategi allow expedi access two type most common six member lactam dihydroquinolinon piperidinon high yield enantioselect protocol featur good function group toler well broad substrat scope newli develop chiral quinox skeleton ligand key paramet transform signific enhanc reactiv enantioselect | D000475;D001688 | T121;T109;T123 |
36,216,793 | human papillomavirus integr perspect small cell cervic carcinoma small cell cervic carcinoma sccc rare aggress malign report human papillomavirus featur genom landscap sccc via high throughput hpv captur sequenc whole genom sequenc whole transcriptom sequenc oncoscan microarray hpv infect integr common detect besid myc famili gene identifi sox nra ankrd cea famili gene hpv integr hotspot construct genom local haplotyp around hpv integr site find tandem duplic amplifi hpv long control region lcr propos three promin hpv integr pattern duplic oncogen mycn myc nra form fusion fgfr tacc ankrd ndufv activ gene myc via cis regul viral lcrs moreov focal cna amplif peak harbor canon cancer gene includ hpv integr hotspot within myc famili sox other find may provid potenti molecular criteria accur diagnosi efficaci therapi lethal diseas | D052685;D018288;D030361;D002583 | T191;T047;T005 |
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