PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,216,197 | isol identif anti inflammatori constitu randia dumetorum lamk fruit potenti benefici effect acut lung injuri randia dumetorum lamk indian tradit medicin plant use treatment various disord includ respiratori ailment | D055371;D019666;D009828 | T002;T123;T109;T037 |
36,216,196 | systemat elucid bioactiv alkaloid potenti mechan sophora flavescen treatment eczema via network pharmacolog sophora flavescen frequent use tradit chines medicin tcm treatment skin disord diarrhea vagin itch inflammatori diseas particular root flavescen combin herb main treat eczema ailment clinic applic howev holist network pharmacolog approach understand mechan alkaloid flavescen treat eczema pursu | D029909;D000470;D004485 | T047;T002;T131;T121;T109;T123 |
36,216,195 | therapeut effect under mechan shenkang inject cisplatin induc acut kidney injuri mice shenkang inject ski chines patent medicin inject approv treatment chronic kidney diseas ckd due definit clinic therapeut efficaci howev effect associ under mechan shenkang inject cisplatin cddp induc acut kidney injuri aki yet well elucid | D002945;D058186 | T121;T047;T037;T197 |
36,216,194 | commelina benghalensi wander jew linn exhibit abortifaci potenti hepatotox pregnant wistar rat via elev indic oxid stress activ proinflammatori cytokin commelina benghalensi linn perenni plant upright stem reach height stem common use induc abort tradit medicin howev insignific scientif data evalu claim | D000019;D056486;D034822 | T047;T002;T037;T121;T039 |
36,216,185 | environment pollut attent deficit hyperact disord meta analysi cohort studi alreadi knowledg extens risk factor attent deficit hyperact disord adhd recent studi suggest environment pollut may contribut increas incid disord aim studi perform systemat review meta analysi risk adhd peopl younger year old exposur environment pollut search medlin embas scielo cinahl lilac cochran central web scienc databas investig grey literatur incept may cohort studi provid data exposur environment pollut adhd children adolesc age zero year old includ two review independ select studi appli qualiti criteria diverg third review contribut final decis meta analysi risk ratio confid interv calcul metaxl program use random effect model total articl includ systemat review studi met criteria meta analysi involv particip meta analysi suggest children expos higher level heavi metal rr ci low heterogen lead rr ci moder heterogen greater risk develop adhd expos lower level meta analysi suggest children expos higher level lead heavi metal pollut greater risk develop adhd expos lower level | D001289 | T048 |
36,216,184 | physiolog select toler social wasp expos malathion insect pest infest worldwid problem result human action among aed aegypti stand vector sever diseas like pest aegypti becom resist insecticid use control thus harm local fauna non target insect therefor aim studi studi physiolog select social wasp expos malathion well investig possibl resist insecticid adult swarm speci polybia platycephala protopolybia sedula independ speci polist versicolor expos four malathion concentr overal malathion select p versicolor toxic p platycephala despit decreas concentr product recommend manufactur theori would subleth dose social wasp still exhibit high mortal rate compar mortal speci collect area applic insecticid area regular applic data show indic popul non target insect also becom resist insecticid especi urban environ | D007306;D014863;D011722;D000330 | T109;T131;T204 |
36,216,183 | critic review microplast degrad materi flow analysi toward circular economi resili low cost plastic made usag ubiquit also caus preval longev wast plastic pollut becom great concern health wellb ecosystem around world microplast particular threat due high mobil eas ingest wildlif abil adsorb carri toxic contamin materi flow analysi wide appli examin stock flow materi industri recent appli plastic examin area wast reach environ howev much research gone environment fate microplast degrad strategi lesser focus materi flow analysi microplast suffer lack data furthermor varieti plastic addit contamin pose signific challeng degrad mere fragment microplast particl review discuss current degrad strategi solut deal exist newli generat microplast wast along examin status microplast base materi flow analysi critic evalu possibl incorpor microplast wast circular economi degrad strategi critic examin identifi challeng current trend well import consider frequent report emphasi place identifi miss data inform materi flow analysi degrad method could prove crucial improv understand microplast flow well optim degrad strategi minim negat environment impact | D000080545;D014874 | T131;T122 |
36,216,182 | chronolog trace element radionuclid use sediment core golden horn estuari sea marmara trace element radionuclid substanti pollut marin environ sinc non biodegrad harm even minut concentr golden horn estuari inlet bosphorus two creek serious pollut untreat municip industri discharg sever decad sinc larg restor rehabilit effort undertaken estuari mitig pollut present studi four sediment core taken golden horn estuari assess histor accumul trace element radionuclid radiometr date implement pb cs radionuclid crs model sediment rate calcul rang cm yr estuari distribut radionuclid k ra ra indic slight variat ascrib geolog characterist sediment along core concentr anthropogen element relat higher intens industri period concentr reduc latest year thank larg scale rehabilit project estuari pollut indic name ef igeo cf pli show concentr cd cr cu pb sb sn world averag result provid insight long term accumul trend trace element golden horn reveal estuari remain moder pollut suggest prevent countermeasur much import post pollut remedi case metal pollut estuari | D014131;D014874;D019216 | T121;T131;T123;T196 |
36,216,181 | associ bifenthrin exposur glucos homeostasi type diabet mellitus general chines popul role protein carbonyl advers health effect pyrethroid exposur attract wide concern aim assess associ bifenthrin wide use pyrethroid glucos homeostasi risk type diabet mellitus tdm explor under mechan serum bifenthrin fast plasma glucos fpg fast plasma insulin fpi plasma protein carbonyl pco determin among particip wuhan zhuhai cohort glucos homeostasi evalu fpg fpi homeostasi model assess insulin resist homa ir impair fast glucos ifg abnorm glucos regul agr associ serum bifenthrin glucos homeostasi risk tdm assess general linear model logist regress model role pco associ evalu mediat analys adjust covari fold increas serum bifenthrin associ mmoll increas fpg increas fpi homa ir pco level respect monoton elev or ifg agr p p trend detect associ increas bifenthrin compar particip low bifenthrin low pco particip high bifenthrin exposur high pco show mmoll increas fpg fpi homa ir well increas risk ifg agr respect p trend moreov pco mediat serum bifenthrin associ glucos dyshomeostasi studi suggest bifenthrin exposur dose depend associ glucos dyshomeostasi general chines urban adult associ exacerb part mediat pco given pollut includ studi effect co exposur pyrethroid multipl pollut necessari consid futur studi | D003924;D007333;D011722;D004785 | T047;T046;T131;T109 |
36,216,180 | unexpect synergist toxic caus competit bioconcentr perfluoroalkyl acid mixtur daphnia magna promot elev temperatur mix pollut global water environ perfluoroalkyl acid pfaa ecolog risk arous widespread concern howev relationship combin toxic pfaa mixtur accumul aquat organ well understood context global warm studi bioconcentr combin toxic three pfaa mixtur pfoa pfda pfdoa daphnia magna magna differ exposur concentr temperatur result show although competit bioconcentr exist combin toxic pfaa mixtur magna synergist contradictori phenomena occur although longer chain pfdoa inhibit bioconcentr shorter chain pfoa pfda bioconcentr pfdoa promot pfdoa toxic magna pfoa pfda toxic equival concentr pfaa mixtur time higher obtain simpl addit three pfaa expos separ moreov elev temperatur promot bioconcentr pfaa competit bioconcentr shorter chain longer chain paff also synergist toxic pfaa mixtur magna studi suggest effect interact among differ pfaa bioconcentr toxic differ water environment condit temperatur consid ecolog risk assess pfaa mixtur | D005466;D014874 | T109;T131 |
36,216,179 | behavior transport posit regul mechan zno nanoparticl plant soil microb environ zno nanoparticl zno nps wide use sever field potenti novel fertil promot plant growth effect use zno nps necessari understand influenc mechan key interact soil physic biolog environ review summar fate transport zno nps appli via soil treatment foliar spray plant soil system discuss posit regul mechan plant microb latest research show format bioavail locat zno nps experi complic chang transport soil plant system depend mani factor zno nps improv plant photosynthesi nutrient element uptak enzym activ relat gene express well modul carbonnitrogen metabol secondari metabolit antioxid system plant sever microbi group relat plant growth diseas biocontrol nutrient cycl soil alter zno np treatment work present systemat comparison zno np fertil convent zinc salt fertil also fill sever knowledg gap current studi hope provid guidanc futur research | D015034;D012989 | T121;T131;T197 |
36,216,178 | natur colloid facilit transport steroid estrogen satur porous media mechan process steroid estrogen ses typic endocrin disrupt compound edc wide detect terrestri environ whilst transport ses groundwat remain unwel understood specif effect ubiquit natur colloid ses transport unclear subsurfac environ especi aquif system influenc inorgan colloid ie silica illit organ colloid ie humic acid ha transport estron e estradiol e satur porous media studi util laboratori scale column experi character colloid porous aquif materi conduct provid basi interpret experiment find result show transport ses clear affect natur colloid migrat satur porous media e e retain column colloid absent system transport silica colloid illit colloid ha colloid transport e enhanc respect whilst transport e improv respect ses transport enhanc colloid depend upon mobil colloid also geochem characterist organ colloid show time greater abil promot transport ses inorgan one test studi propos mechan natur colloid facilit transport ses includ compet adsorpt site sand surfac colloid result mobil adsorb ses solid matrix transport colloid carrier ses | D003102;D006812 | T109;T123;T122 |
36,216,177 | beach litter survey drone mini review discuss potenti standard abund beach litter increas global last decad issu global concern new survey strategi base uncrew aerial vehicl uav aka drone recent adopt improv monitor beach macro litter item abund distribut work identifi analys studi use drone beach litter survey oper basi analysi technic paramet drone flight deploy reveal flight altitud vari analysi final assess show manual andor autom item detect imag studi provid litter bulk characterist type materi size along litter distribut map potenti standard drone base litter survey would allow comparison among survey howev seem difficult propos standard set flight paramet given wide varieti coastal environ differ devic avail divers object drone base litter survey hand view set common outcom propos base grid map process easili generat follow procedur indic paper work set ground develop standard protocol drone litter data collect analysi assess would allow provis broad scale compar studi support coastal manag nation intern scale | D001493;D014866 | T167;T083 |
36,216,170 | non b dna conform analysi molecular dynam simul non b dna conform molecular structur follow canon dna doubl helix mutagenet instabl nuclear mitochondri dna mtdna genom associ simpl non b dna conform hairpin complex structur g quadruplex one structur structur cloverleaf like non b conform predict nt nucleotid stretch mtdna control region peripher domain structur embed hot spot end human mtdna delet reveal import influenc mutat instabl mtdna genom | D056004;D054856 | T044;T066;T086 |
36,216,169 | detect mild cognit impair type diabet mellitus base machin learn use privileg inform type diabet mellitus tdm patient may develop mild cognit impair mci even dementia howev lack reliabl machin learn model detect mci tdm patient base machin learn method addit brain network chang associ mci studi aim studi develop machin learn base algorithm help detect mci tdm particip includ studi divid tdm mci n tdm nonmci n normal control n accord neuropsycholog evalu function connect particip construct base rest state magnet reson imag rs fmri featur select use reduc featur dimens select featur set cascad multi column random vector function link network rvfl classifi model use privileg inform final optim model train classif perform obtain use test data result show propos algorithm outstand perform compar classic method classif accuraci tdm mci vs nc tdm mci vs tdm nonmci achiev function connect relat tdm mci main distribut frontal lobe tempor lobe central region motor cortex could use neuroimag biomark recogn mci tdm patient studi provid machin learn model diagnosi mci tdm patient potenti clinic signific time intervent treatment delay develop mci | D000544;D003924;D060825 | T047;T048 |
36,216,148 | neoantigen discoveri applic glioblastoma immunotherapi perspect glioblastoma gbm common aggress malign involv human brain poor prognosi although various advanc treatment strategi incorpor clinic practic especi surgic resect follow radiotherapi chemotherapi median patient surviv approxim month chimer antigen receptor car cell use success hematolog cancer howev car cell therapi solid malign especi gbm challeng immun checkpoint inhibitor ici although effect solid tumor limit use patient gbm neoantigen deriv somat mutat express tumor cell led new approach cancer immunotherapi person vaccin adopt cell therapi act two main treatment method target neoantigen efficaci various cancer two clinic trial person vaccin gbm demonstr immunogen safeti review develop neoantigen main field gbm possibl therapeut applic challeng addit organoid preserv heterogen molecular signatur gbm may play vital role studi neoantigen gbm | D001932;D005909;D000076962 | T191;T192;T116;T129 |
36,216,145 | spatiotempor encod mri use subspac constrain sampl local low rank regular applic diffus weight diffus kurtosi imag human brain prostat benefit perform local low rank llr reconstruct subsampl diffus weight diffus kurtosi imag data employ spatiotempor encod spen method investig spen allow self referenc correct motion induc phase error case interleav diffus orient acquisit allow one overcom distort otherwis observ along epi phase encod dimens combin llr base reconstruct pool imag data joint subsampl b weight interleav imag addit improv term sensit well shorten acquisit time demonstr without notic penalti detail llr regular subspac constrain imag reconstruct adapt spen given improv introduc adopt reconstruct framework acceler acquisit diffus kurtosi imag data relat homogen region like human brain challeng region like human prostat present discuss within context similar effort field | D011467;D000465 | T023;T170 |
36,216,144 | brushit nanoparticl base electrochem sensor detect uric acid xanthin hypoxanthin caffein research field biosensor recent focus design develop function electrod materi respond chang biochem environ report synthesi dicalcium phosphat dihydr dcpd also known brushit cahpo h soft chemic method applic electrochem sens four differ analyt phase puriti structur chemic composit surfac morpholog synthes nanoparticl investig use powder xrd ftir sem xps hrtem method electrochem sensor prepar modifi gce brushit modifi electrod success use either independ simultan determin uric acid xanthin hypoxanthin caffein mixtur brushitegc exhibit four strong well defin separ peak correspond oxid ua xn hxn cf phosphat buffer salin pbs ph fabric electrod show low detect limit sn ua xn hxn cf respect practic applic fabric electrod demonstr determin ua xn hxn cf human urin coffe sampl direct method brushit offer scope fabric sensor system implant medic applic | D014527;D053758 | T109;T123;T073;T114 |
36,216,143 | integr fluoresc later flow assay multiplex point care detect four respiratori virus work establish high sensit specif quantum dot nanobead base later flow assay multiplex detect four respiratori virus marker point care respiratori virus antigen detect fluoresc later flow strip within min limit detect sar cov antigen iav antigen ibv antigen adv antigen ngml ngml ngml ngml respect superior convent aunp base colorimetr later flow assay coeffici variat test strip four antigen indic propos method good repeat specif detect system verifi differ combin four respiratori virus sever respiratori pathogen result indic method could simultan detect sar cov iav ibv adv short assay time show remark potenti rapid multiplex detect respiratori virus resourc limit set | D000086382;D053768;D014780 | T047;T073;T067;T005 |
36,216,131 | therapeut target glutam dehydrogenas link metabol reprogram snail mediat epitheli mesenchym transit drug resist lung cancer acquir drug resist epitheli mesenchym transit emt mediat metastasi two high interact determin non small cell lung cancer nsclc prognosi studi investig common mechan drug resist emt perspect metabol reprogram may offer new idea improv anticanc therapi acquir resist cell found grow faster greater migratori invas capac parent cell metabolom analysi reveal acquir resist cell high reli glutamin util main flux oxid phosphoryl energi product mechanist studi screen glutam dehydrogenas glud determin glutamin addict acquir resist nsclc cell provid evid glud mediat kg product accompani reactiv oxygen speci ros accumul primarili trigger migrat invas induc snail pharmacolog genet interfer glud vitro signific revers drug resist decreas cell migrat invas capabl last success applic r select glud inhibitor overcom acquir resist emt induc metastasi vivo identifi glud promis druggabl therapeut target malign progress nsclc collect studi offer potenti strategi nsclc therapi especi drug resist patient high express glud | D002289;D008175 | T191 |
36,216,130 | adropin increas swim exercis exert protect effect brain age rat adropin protein brain decreas age exercis protect effect endothelium increas level adropin circul studi whether adropin whose level brain decreas age may increas swim exercis exhibit protect effect investig young age male spragu dawley rat submit h swim exercis everi day week motor activ paramet record end exercis wait period anim euthan increas motor function observ young rat exercis regular adropin level plasma adropin vegfr immunoreact p akt ser level frontal cortex signific increas age rat exercis regular also observ baxbcl ratio ros rns level decreas tac level increas age rat exercis regular result studi indic low moder chronic swim exercis protect effect increas level adropin frontal cortex tissu age rat adropin thought achiev effect increas vegfr express level caus akt ser phosphoryl result indic exercis mediat increas endogen adropin may effect prevent destruct effect age brain | D013550;D010805 | T038;T056 |
36,216,119 | lncrna bbox silenc inhibit esophag squamous cell cancer progress promot ferroptosi via mir pslca axi long noncod rna bbox antisens bbox demonstr play import role sever tumor howev express function bbox esophag squamous cell cancer escc defin bbox express collect escc tissu pair adjac normal tissu escc cell line analyz use quantit real time polymeras chain reaction overal surviv patient also studi cell prolifer invas migrat verifi construct vitro model addit cell apoptosi determin flow cytometri ferroptosi examin use ptgs detect lipid reactiv oxygen speci assay relationship bbox downstream molecul evalu use rna immunoprecipit western blot luciferas report assay function bbox studi vivo use xenograft model immunohistochemistri bbox express signific higher escc tissu indic poor prognosi inhibit bbox reduc cell prolifer slow cell invas migrat promot apoptosi ferroptosi vitro mir p verifi specif target bbox escc wherea knockdown mir p revers suppress function bbox silenc te cell moreov solut carrier famili member slca regul mir p mediat bbox escc cell conclus downregul bbox inhibit cell prolifer metastasi acceler cell apoptosi ferroptosi escc upregul mir p reduc slca express find may provid novel insight diagnosi treatment escc | D062085;D000079403;D002294;D035683;D004938;D000077277 | T191;T043;T123;T114 |
36,216,115 | metagenom evid increas antibiot resist progeni upon parent antibiot exposur cost hormesi antibiot wide consum intens maricultur industri better understand effect antibiot intergener antibiot resist organ urgent sinc intergener transmiss crucial spread antibiot resist gene arg environ herein marin medaka oryzia melastigma chronic expos low dose sulfamethazin smz hormet affect progeni character increas rich divers fecal microbiota intestin barrier relat gene regul progeni immun modul caus genet factor due absenc signific smz accumul f embryo addit top genera progeni posit correl immun diseas express immun relat gene tnf ilr tlr chang signific indic host select caus chang progeni immun probabl primari determin progeni intestin microbi colon metagenom analysi reveal proteobacteria repres primari carrier arg parent smz exposur facilit distribut enrich multipl arg involv antibiot inactiv progeni promot divers gammaproteobacteria bacteroidet illustr antibiot select pressur persist even offspr expos therefor smz induc hormesi progeni expens increas antibiot resist collect find provid comprehens overview intergener effect antibiot serv remind arg transmiss induc intergener impact antibiot organ ignor | D000900;D014409 | T121;T129;T116;T195 |
36,216,113 | combin metal sulfat isotop measur identifi differ anthropogen impact dissolv heavi metal level river water dissolv heavi metal dhms contamin rais global concern ecolog human health develop weather sulfid bear ore metal produc acid sulfat rich solut presenc water oxygen dhms releas deprav river water qualiti sulfur oxygen isotop signatur could identifi pyrit deriv sulfat howev yet well known whether valu could limit dhms sourc illustr anthropogen impact dhms along river corridor tri solv problem field work luoh river yihe river two tributari yellow river china metal sulfid mine activ most occur upstream agricultur domest behavior concentr lower plain reach luoh river upper area valu negat correl concentr cadmium cd p nickel ni p molybdenum mo p uranium u p p howev valu increas downstream luoh river concentr copper cu p mercuri hg p ni p p simultan elev bayesian isotop mix model bimm result via valu demonstr acid mine drainag amd luoh river upper reach yihe river upper reach sewag industri effluent luoh river lower reach yihe river lower reach result confirm differ anthropogen impact dhms concentr luoh river yihe river provid robust method dhms sourc appoint pollut manag river system | D014874;D019216;D008628 | T131;T196 |
36,216,112 | valor floral foam wast via pyrolysi optim enhanc phenol recoveri util phenol formaldehyd foam becom increas widespread especi floral bouquet generat toxic microplast environ present studi evalu phenol recoveri floral foam wast ffw floral bouquet optim pyrolysi condit compar biomass portion floral bouquet ffw show higher carbon content lower nitrogen content lower oxygen content highest record calorif valu mj kg thermogravimetr analysi show relat thermal stabil ffw gradual weight loss numer small peak c repres short chain volatil formaldehyd phenol c due phenol aromat product releas indic rich ffw phenol compound optim pyrolysi condit show highest signific biocrud yield c min use ffw load g howev optim phenol product suggest c min g ffw load optimum condit high biocrud yield enhanc phenol proport experiment result use aforement condit show phenol potenti g phenolicsg ffw phenol compound compos main phenol methyl deriv | D000077319;D010636 | T121;T109;T070 |
36,216,111 | airborn polystyren microplast nanoplast induc nasal lung microbi dysbiosi mice microplast mp nanoplast np found multipl environ creatur howev effect airway microbiota still remain poor understood studi seri bioinformat statist analys carri explor influenc airborn mp np nasal lung microbiota mice mp np capabl induc nasal microbi dysbiosi mp stronger influenc lung microbiota np multipl nasal lung bacteria associ mp np group among nasal staphylococcus lung roseburia associ mp group nasal prevotella lung unclassifiedmuribaculacea associ np group nasal staphylococcus lung roseburia lung eggerthella lung corynebacterium associ mp np group potenti biomark micronanoplast induc airway dysbiosi sarcladeia sarcladeii associ nasal lung microbiota mp group bacterium determin np group relev result suggest airborn mp np could induc nasal lung microbi dysbiosi relev prevent curabl strategi deserv investig | D064806;D000080545 | T047;T046;T122 |
36,216,110 | characterist sludg base pyrolysi biochar applic enhanc denitrif modifi biochar enhanc denitrif develop facil pyrolysi method use sewag sludg raw materi melamin nitrogen sourc electrochem analysi sludg base pyrolysi biochar spbc superior electr conduct poor redox activ spbc increas electron transfer geoconductor mechan effect mechan spbc denitrif studi nitrat treatment effici increas increas spbc dosag perspect molecular biolog activ nar nir enzym degrad effici glucos etsa bacteria promot increas spbc therebi promot remov addit spbc certain screen effect microbi communiti biodivers decreas increas spbc dosag although biodivers decreas relat abund microorgan conduc denitrif increas increas spbc dosag transform strategi spbc propos paper provid technic solut sludg recycl applic strengthen denitrif | D012722;D000077319 | T069;T070 |
36,216,109 | studi nano cellulos base membran tailor biodegrad use packag applic electron devic grow demand packag materi wit mani landfil huge garbag island float pacif ocean need altern materi bio degrad plastic risen cellulos base materi alreadi use sever packag industri nanocellulos process cellulos specif nanostructur sever advantag high specif strength modulus high surfac area uniqu optic properti vari crosslink percentag kinet degrad tailor work extract cellulos sugarcan bagass hydrolyz obtain nanocellulos use fabric packag film membran pva matrix nanocellulos variat pva nanocellulos load crosslink agent ratio fabric film investig chemic mechan optic thermal topograph properti result degrad test appropri physic simul environ suggest crosslink enhanc mechan properti extent degrad depend percentag crosslink real world devic packag applic demonstr encapsul perovskit solar cell fabric nanocellulos film reveal lifetim devic improv might indic film lower permeabl oxygen moistur | D002482;D031786 | T002;T109;T123;T122 |
36,216,108 | high effici fluorid retent site solidificationstabil phosphogypsum cement past backfil synerg poli aluminum chlorid activ phosphogypsum pg massiv generat hazard product phosphorus industri larg scale effici profit site recycl emerg topic promot sustain phosphorus circular mitig potenti human exposur work integr green low cost addit polymer aluminum chlorid pac binder design pg immobil overal experiment result illustr incorpor pac effici promot cement hydrat reaction amorph phase increas wt control group wt gl pac macro investig indic pac optim poros mechan properti specimen facilit mechan stabl solidifi matrix extrapol field engin applic detail micrograph element map demonstr apart co exist hydrat product pac agent play role immobil fluorid herein combin optim enhanc fluorid retent capac due precipit addit hydrat product compar encapsul high adsorpt abil pac agent therefor design pac augment binder open new field pg site solidificationstabil applic ensur effici fluorid retent technic feasibl financi profit methodolog | D005459;D002133 | T121;T122;T197 |
36,216,106 | fast stress relax gellan gum enhanc microenviron secret function bone mesenchym stem cell studi show tunabl stress relax gellan gum gg hydrogel enhanc cell growth regen medicin molecular weight physic crosslink densiti gg tune character physicochem analysi mechan test result show decreas molecular weight gg correl declin mechan properti faster stress relax charact also discov human deriv bone marrow stem cell hbmsc show activ viabil prolifer remodel fast stress relax gg hydrogel particular hbmsc show enhanc releas profil growth factor exosom exo fast stress relax gg hydrogel secretom obtain hbmsc embed hydrogel exhibit similar cytotox wound heal properti secretom extract hbmsc cultur tissu cultur plate tcp standard cultur condit thus work demonstr potenti fast stress relax gg hydrogel medic applic | D011135;D059630 | T025;T109;T129 |
36,216,105 | activ crosslink lipas mesopor silica via lid open recycl biodiesel product lipas catalyz wide rang industri import reaction includ transesterif triglycerid alcohol biodiesel product stabil lipas critic achiev recycl use nanoscal enzym reactor ner lipas rhizopus oryza lp prepar via simpl two step process compris enzym adsorpt magnet separ mesopor silica follow crosslink adsorb enzym aqueous phase specif hydrolysi activ ner lp time lower free lp hand howev specif transesterif activ ner lp molminmg lp organ phase biodiesel product time higher free lp molminmg lp result reveal enzym crosslink prepar ner interfer interfaci activ lp molecul open lid lp activ site optim hydrophob environ provid combin organ solvent mesopor silica magnet separ optim wash protocol facilit recycl use ner lp high stabl activ ner lp magnet separ mesopor silica demonstr great potenti environment friend nanobiocatalyst various lipas applic includ plastic biosurfact function fatti acid well recycl biodiesel product | D056804;D012822 | T109;T197 |
36,216,104 | enhanc thermal stabil galactosidas bgab bacillus circulan cyclize mediat via spytagspycatch interact use galacto oligosaccharid synthesi cyclize protein use spytagspycatch novel approach increas thermal stabil paper test approach two galactosidas bacillus circulan bgab bgac find bgab stabil bgac wild type bgab precipit complet upon heat c spyre cyclize remain solubl heat c similar wild type bgab retain activ heat c min increas spyre cyclize contrast cyclize decreas stabil bgac spyre cyclize bgac retain activ min incub c wherea wild type bgac retain activ one reason differ effect cyclize may shorter distanc n c termini bgab compar bgac intrins fluoresc circular dichroism spectra suggest spyre cyclize bgab signific chang conform secondari structur spyre cycliz bgab yield similar amount composit galacto oligosaccharid use high initi lactos concentr wv slight higher amount low initi lactos concentr wv suggest increas transgalactosyl activ | D007785;D009844 | T121;T109;T123 |
36,216,103 | prepar hydrophob composit membran base carboxymethyl cellulos modifi pectin effect graft long chain satur fatti acid studi docosano acid long chain fatti acid use modifi pectin product incorpor carboxylmethyl cellulos cmc prepar hydrophob composit result structur characteris show docosano acid graft pectin esterif reaction highest graft ratio graft docosano acid emulsifi activ stabil pectin signific enhanc moreov modifi pectin blend cmc instead nativ pectin hydrophob composit membran increas signific detail highest contact angl composit membran incorpor modifi pectin much higher nativ pectin graft ratio pectin increas water vapor permeabl composit membran signific increas water absorpt decreas furthermor mechan properti transpar composit membran could improv graft docosano acid pectin result indic incorpor docosano acid possibl help improv comprehens properti composit membran base polysaccharid expand applic food packag | D002266;D010368 | T121;T109;T123 |
36,216,102 | zinc sulfid mediat poli hydroxybutyr poli lactic acid nanocomposit film potenti uv protect applic present studi dealt fabric zinc sulfid zns nanoparticl nps prepar use chemic precipit method mediat poli hydroxybutyr phb poli lactic acid pla composit film employ solut cast approach film character base structur surfac chemo physic thermal electr antibacteri uv protect degrad profil result demonstr success format nanobiocomposit film good intercal constitu surfac morpholog result express placement zns nps polymer blend support element analysi xrd analysi exhibit crystallin behavior nanobiocomposit film surfac wettabl analysi indic inclus zns nps water contact angl result film observ prepar nanobiocomposit film exhibit thermal stabil c tensil strength mpa compar nativ phb mpa pla mpa film nanobiocomposit film express good antibacteri properti compar control prepar film express degrad trend natur environ zns nps inclus plaphb blend could enhanc ac conduct result nanobiocomposit film accept uv protect properti applic uv protect pack | D011091;D053761 | T109;T073;T122 |
36,216,101 | decennari updat divers heterocycl intermedi privileg scaffold cathepsin b inhibit identif x ray crystal structur cathepsin b ctsb earli enabl research embark journey understand demystifi multipl catalyt mechan endopeptidasecarboxypeptidasepeptidyl dipeptidas divers physiolog process switch one anoth differ condit engag ctsb differ patholog condit due express highlight enhanc research interest around domain occurr express ctsb various diseas like alzheim cancer arthriti cardiovascular etc use ctsb inhibitor treatment diseas establish involv differ patholog condit understand tempt research design synthes screen divers class compound ctsb turn help understand interact activ site enzym heterocycl compound compris rich broad class medicin import compound also hold great potenti ctsb inhibit review cover ctsb inhibit potenti various natur synthet heterocycl scaffold research work field molecular model drug design develop enzym inhibitor benefit signific review | D009369;D006571 | T191;T109 |
36,216,084 | compar select vowel represent cortic auditori vs motor area repetit suppress studi comput model speech percept cosmo laurent et al predict speech sound evok auditori represent tempor area motor represent main inferior frontal area import model also predict auditori represent narrow ie focus typic stimuli motor represent would toler atyp stimuli base assumpt repetit suppress studi function magnet reson imag data show sequenc ident vowel sound produc lower cortic activ ie larger suppress effect last sound sequenc slight vari crucial tempor region display increas cortic activ even small acoust variat indic releas suppress effect even stimuli acoust close first stimulus contrast inferior frontal premotor insular cerebellar region show releas suppress larger acoust variat auditori narrow motor wide pattern vowel stimuli add number similar find conson stimuli confirm select speech sound represent tempor auditori area narrow frontal motor area human cortex | D009044;D001303;D013067 | T023;T041;T029 |
36,216,079 | tangeretin prevent cognit deficit delirium activ ror ebp axi mice delirium common serious neuropsychiatr syndrom character acut cognit attent deficit howev effect therapi lack use mous model delirium investig effect tangeretin tan natur flavonoid cognit impair assess object prefer novel object recognit test spontan altern maze test found tan ror agonist prevent cognit declin deliri mice evidenc normal novel object prefer increas spontan altern accompani decreas express erk tnf il well diminish microgli activ deliri mice protect effect tan delirium main attribut increas hippocamp ebp express known target ror regul cognit delirium modul erk cascad microgli activ via activ ror addit tan treatment modul express ror target gene ebp bmal inhibit express tnf il lipopolysaccharid lps stimul cell support benefici effect tan delirium conclus tan identifi ror agonist promot ebp express prevent cognit declin deliri mice find may implic drug develop tan prevent treatment various diseas associ cognit defici | D047309;D060825;D003693 | T109;T048 |
36,216,077 | exposur melamin cyanur acid adult mice caus motor activ skelet muscl energi metabol disord thyroid hormon varieti physiolog function play import role develop central nervous system skelet muscl lung well bodi temperatur regul skelet muscl key determin basal metabol rate system energi metabol contain myopsin sln play import role muscl heat product energi metabol melamin cyanur acid mca import compon new flame retard also chemic interf substanc affect endocrin bodi main distribut nylon flame retard substanc therefor studi male mice expos mca mgkg four week explor effect mca exposur skelet muscl morpholog thermogen gene express motor activ explor whether mca exposur could induc skelet muscl hyperthermia energi metabol disord under mechan result show motor activ male mice expos mca decreas morpholog skelet muscl tissu impair level morpholog thermogen gene skelet muscl destroy find intend provid preliminari refer studi effect mca exposur thermogenesi energi metabol adult mice | D005411 | T120 |
36,216,041 | remot microphon system cochlear implant recipi small group set cochlear implant ci recipi often experi speech recognit difficulti nois small group set multipl talker tradit remot microphon system one talker wear remot microphon wireless deliv speech ci processor system transmit signal multipl talker small group howev remot microphon system multipl microphon allow adapt beamform may benefici small group situat multipl talker specif remot microphon adapt multipl microphon beamform may place center small group beam ie polar lobe may automat steer toward direct associ favor speech nois ratio signal remot microphon wireless deliv ci sound processor altern talker small group may use remot microphon part multi talker network wireless deliv remot microphon signal ci sound processor purpos studi compar potenti benefit adapt multipl microphon beamform remot microphon system multi talker network remot microphon system | D019929;D003054;D013067 | T061;T074;T041 |
36,216,040 | influenc motor maneuv cervic vestibular evok myogen potenti cvemp cervic vestibular evok myogen potenti cvemp vestibular respons produc saccul respons intens often low frequenc short durat auditori stimuli typic record contract sternocleidomastoid scm muscl previous research shown amplitud cvemp relat amount scm electromyograph emg activ | D058585 | T034 |
36,216,039 | video head impuls test person blind feasibl outcom achiev balanc person blind pwb use propriocept vestibular cue rather visual system howev pwb equal suscept acquir vestibular disord reliabl assess vestibular system pwb essenti determin presenc absenc vestibular disord | D064087;D015837 | T047;T060 |
36,216,031 | design synthesi anti tumor activ studi novel pyrido pyrimidin deriv order find high effici low toxic anti tumor drug pyrido pyrimidin compound design synthes evalu mtt assay vitro result present compound good antitumor activ among compound best anti tumor activ mgc cell ic mechanist studi exhibit compound inhibit migrat mgc induc apoptosi prove compound regul express bid parp regul express cycd western blot experi studi indic compound might serv lead agent treatment human gastric cancer | D000970;D011743;D017209 | T116;T121;T109;T123;T114;T043 |
36,216,029 | corticotropin releas factor nucleus basali meynert impair attent perform reduc level glutam taurin male femal rat psychiatr disord character impair sustain attent includ attent deficit hyperact disord adhd post traumat stress disord ptsd major depress also sensit exacerb stress sustain attent reli cholinerg non cholinerg project nucleus basali meynert nbm basal forebrain medial prefront cortex mpfc previous shown central administr stress neuropeptid corticotropin releas factor crf impair perform sustain attent task sat adult male femal rat present studi investig whether effect mediat crf action nbm rat administ crf nbm subsequ sat perform measur high dose crf ng signific impair perform non signal event across sex perform non signal event believ depend non cholinerg ie gaba glutam signal high perform liquid chromatographi use quantifi amino acid level nbm mpfc found femal higher level glutam glutamin gaba glycin alanin nbm male import crf nbm led local decreas taurin sever amino acid involv glutam synthesi male femal chang may mediat crf induc sat perform deficit togeth studi suggest crf regul amino acid nmb contribut stress induc attent deficit | D020532;D003346 | T121;T023;T116;T125 |
36,216,007 | real world effect molnupiravir nirmatrelvir plus ritonavir mortal hospitalis hospit outcom among communiti dwell ambulatori patient confirm sar cov infect omicron wave hong kong observ studi littl known real world effect oral antivir sar cov omicron b variant aim assess clinic effect two oral antivir drug among communiti dwell covid outpati hong kong | D000086382 | T047;T067 |
36,216,006 | allopurinol versus usual care uk patient ischaem heart diseas heart multicentr prospect randomis open label blind endpoint trial allopurinol urat lower therapi use treat patient gout previous studi shown allopurinol posit effect sever cardiovascular paramet heart studi aim determin whether allopurinol therapi improv major cardiovascular outcom patient ischaem heart diseas | D003324;D006073;D009203;D017202;D020521 | T047 |
36,215,978 | pregnanc outcom among perinat hiv infect women spain increas number women live perinat acquir hiv reach adulthood becom pregnant achiev viral suppress challeng popul frequent expos numer antiretrovir regimen studi describ long term outcom pregnant women live perinat acquir hiv spain | D019380;D011251;D015658;D000163 | T121;T047 |
36,215,977 | applic site evalu cervic cytolog smear stain toluidin blue reduc unsatisfactori result carcinoma uterin cervix major health problem face indian women screen techniqu like visual inspect acet acid lugol iodin papanicolaou smear human papillomavirus dna test suggest pap smear simpl safe cost effect reliabl techniqu use screen cervic lesion rapid site evalu rose use aq toluidin blue stain method less studi cervic cytolog | D018290;D002583;D065309;D002294 | T191;T025;T033 |
36,215,976 | deep learn base remot photoplethysmographi measur short time facial video object effici non contact heart rate hr measur facial video receiv much attent health monitor past method reli prior knowledg unproven hypothesi extract remot photoplethysmographi rppg signal eg manual design region interest roi skin reflect model approach paper present short time end end hr estim framework base facial featur tempor relationship video frame propos method deep multi scale network cross layer residu structur design construct autoencod extract robust rppg featur spatial tempor fusion mechan propos help network focus featur relat rppg signal shallow fuse spatial tempor featur distil suppress redund inform complex environ final data augment strategi present solv problem uneven distribut hr exist dataset main result experiment result four face rppg dataset show method overperform state art method requir fewer video frame compar previous best result propos method improv root mean squar error rmse obf dataset intra test cohfac dataset intra test ubfc dataset cross test respect signific method achiev good result divers dataset ie high compress video low resolut illumin variat demonstr method extract stabl rppg signal short time | D017156;D000077321 | T060;T066 |
36,215,970 | captur wake captur numer investig wing wake interact aerodynam wing generat lift leav behind region disturb air form wake hover insect wing must return wake produc previous half stroke signific effect aerodynam perform paper numer investig wing interact wake reynold number enabl improv understand under physic wake captur aerodynam mechan insect flight adopt simpl kinemat motion pattern compris translat stroke motion follow complet stop expos wake interact effect repres stroke distanc chord ratio consid enabl differ lead edg vortex lev attach state also allow pitch rotat toward end stroke lead wake intercept angl analog delay symmetr advanc pitch rotat insect wing shown vortex suction jet flow imping mechan lead either posit negat effect depend lev attach state stroke distanc result detachedattach lev lead beneficialdetriment wake interact lift pitch rotat end stroke motion found induc strong rotat trail edg vortex rtev advanc pitch rtev serv enabl either stronger flow imping effect lead posit wake interact lift lev detach less favour vortex suction effect lead negat wake interact lift lev close attach higher reynold number led faster develop wake vortic primari wake interact mechan remain reynold number | D005426;D020521 | T047;T040 |
36,215,965 | pacnav collect navig approach uav swarm depriv communic extern local articl propos persist administ collect navig pacnav approach achiev decentr collect navig unman aerial vehicl uav swarm techniqu base flock collect navig behavior observ natur swarm cattl herd bird flock even larg group human global concurr inform swarm member avail natur swarm system use local observ achiev desir behavior similar pacnav reli local observ relat posit uav make suitabl larg swarm depriv communic capabl extern local system introduc novel concept path persist path similar allow swarm member analyz motion member order determin futur motion pacnav base two main principl uav littl variat motion direct high path persist consid uav reliabl leader b group uav move similar direct high path similar group assum contain reliabl leader propos approach also emb reactiv collis avoid mechan avoid collis swarm member environment obstacl collis avoid ensur safeti reduc deviat assign path along sever simul experi present real world experi natur forest showcas valid effect propos collect navig approach challeng environ sourc code releas open sourc make possibl replic obtain result facilit continu research communiti | D000401;D012371 | T090;T073 |
36,215,963 | diminish visual attent emot face associ poor emot valenc percept frontotempor dementia current studi examin whether visual attent emot facial express lower individu frontotempor dementia ftd compar healthi control whether visual attent emot facial express associ abil perceiv other emot valenc accur | D057180;D020774 | T047;T048 |
36,215,962 | antibacteri effect situ zinc oxid nanoparticl generat insid poli acrylamid co hydroxyethylmethacryl nanocomposit present work report antibacteri activ pseudomona aeruginosa nanocomposit made zinc oxid nanoparticl dispers poli acrylamid co hydroxyethylmethacryl matrix paam hema znonp situ synthesi znonp insid paam hema crosslink network describ moreov physicochem properti paam hema znonp nanocomposit analyz result confirm paam hema hydrogel provid excel scaffold generat znonp presenc znonp insid hydrogel confirm uv visibl band nm infrar spectroscopi peak cm sem tem imag presenc nps paam hema diminish swell percentag young modulus compar pristin hydrogel znonp releas nanocomposit h spontan diffus allow use nanocomposit antibacteri agent vitro agar diffus test present inhibit halo p aeruginosa bacteria higher unload hydrogel also paam hema znonp livedead test show dead cell hydrogel result suggest easi one step way generat composit use biomed applic antimicrobi agent | D053761;D015034;D053758 | T121;T073;T197 |
36,215,961 | effect hear loss cognit function subject cognit declin subject cognit declin scd self report cognit declin without object cognit impair relationship audiometr hear loss hl cognit function report scd purpos studi investig whether hl affect cognit relat index scd individu | D060825;D034381;D003704 | T047;T048;T033 |
36,215,954 | photophys optic lase analysi fluorin keto carboxyl europium iii complex six luminesc bright red eu iii complex keto carboxyl acid prime ligand n donor aromat system auxillari ligand synthesis via ecolog effici grind method distinct red peak f eu iii ion exhibit emiss spectra complex luminesc properti complex analys decay time color coordin luminesc effici judd ofelt paramet valu found higher indic hypersensit natur f transit result establish complex strong contend red light emit display devic fluoresc branch ratio stimul emiss cross section gain band width optic gain show good lase strength f transit complex complex exhibit decent thermal stabil optic energi band gap valu semiconductor rang thus relev optoelectron devic energi transfer mechan investig complex affirm efficaci transfer energi ligand eu iii ion synthesis complex also assay antimicrobi antioxid properti complex report show better antioxid behaviour prime ligand also exhibit upstand antibacteri activ | D005063;D000975 | T121;T196;T123;T044;T039 |
36,215,941 | evalu viasur neisseria gonorrhoea ciprofloxacin resist assay simultan identif direct detect ciprofloxacin suscept detect resist without need cultur essenti establish guid treatment neisseria gonorrhoea ng infect evalu viasur neisseria gonorrhoea ciprofloxacin resist real time pcr detect kit certest biotec sl zaragoza spain simultan identif direct detect ciprofloxacin suscept ng isol posit ng clinic sampl differ anatom locat sensit ng detect specif sensit test character resistancesuscept ciprofloxacin conclus test evalu suitabl use establish target therapi oral ciprofloxacin case detect resist | D009344;D006069 | T007;T047 |
36,215,940 | correl vitek agar dilut levofloxacin suscept test clinic outcom enterobacteral bacteremia clsi breakpoint clsi lower suscept levofloxacin breakpoint enterobacteral mic gml gml studi evalu correl suscept profil obtain vitek agar dilut ad method levofloxacin mic gml isol clinic impact two hundr fifti three enterobacteral isol patient treat levofloxacin enterobacteral bacteremia enrol analysi categor agreement major error minor error base clsi breakpoint higher levofloxacin mic gml determin use vitek ad predict earli clinic failur p vitek p ad conclus vitek perform levofloxacin suscept test enterobacteral declin accord clsi criteria compar pre criteria although discrep result obtain mic measur vitek could still predict treatment outcom | D064704;D016470 | T121;T047;T109;T195 |
36,215,939 | limit qpcr estim dna quantiti rfu method facilit inter laboratori comparison activ level general applic applic qpcr estim quantiti dna present usual base upon short amplicon typic cbp longer amplicon typic c bp latter use determin amount degrad present sampl data use make decis whether suffici templat amplifi b much elut volum forward pcr typic multiplex amplifi templat region bp consequ result bp amplicon tend overestim actual amplifi quantiti present degrad sampl compens method present relat quantiti amplifi dna averag rfu amplifi fragment provid great improv accuraci estim quantiti dna present may differ order magnitud compar qpcr relat dna quantiti apport per contributor mixtur proport ascertain probabilist genotyp softwar euroformix motiv work provid improv method generat data prepar distribut use inform activ level proposit howev applic benefit particular extract quantif bypass exampl direct pcr rapid dna technolog overal aim work provid method quantif standardis use compar result differ laboratori use differ multiplex softwar solut shinyrfu provid aid calcul | D004247;D012984 | T073;T090;T170;T123;T114 |
36,215,934 | human induc pluripot stem cell generat patient homozyg mutat lyn kinas gene success generat induc pluripot stem cell ipsc dermal fibroblast patient germlin mutat code region lyn kinas gene gain function gof mutat elimin inhibitori tyrosin posit py unknown establish diseas etiolog ipsc carri germlin mutat lyn phenotyp normal capac differenti toward three germ layer ipsc critic studi unknown diseas etiolog understand role lyn kinas autoimmun diseas | D057026;D019061 | T025;T126;T116 |
36,215,931 | insight pandem respiratori virus manipul antivir interferon respons sar cov influenza virus outbreak covid pandem one year centenni influenza pandem reaffirm catastroph impact respiratori virus global health economi key featur sar cov influenza virus iav remark abil suppress dysregul human immun respons summar grow knowledg interplay sar cov antivir innat immun emphasi regul type iii interferon respons critic implic covid pathogenesi furthermor draw parallel iav infect discuss share innat immun sens mechan respect viral countermeasur | D000086382;D007251;D007372;D000086402 | T047;T116;T005;T129;T067 |
36,215,920 | separ enantiom underivat amino acid use serial connect dual column high perform liquid chromatographi tandem mass spectrometri articl serial connect dual column liquid chromatographi tandem mass spectrometri lc msms method describ simultan separ enantiosepar proteinogen amino acid purpos differ achir chiral stationari phase csp mobil phase composit test result optim studi best enatiosepar amino acid achiev combin zwitterion crown ether stationari phase use gradient two mobil phase water tfa vv b acetonitril ethanol tfa vvv develop method provid simultan enantiosepar proteinogen amino acid studi includ isomer isobar one except prolin method success appli human lung adenocarcinoma cell healthi human lung epitheli cell bea b cultiv amino acid contain cocktail order evalu amino acid transfer rate normal cancer line thedl amino acid ratio differ cancer normal cell line cultiv mention aspart acid cystein methionin phenylalanin serin | D000596;D043844 | T121;T109;T123;T116 |
36,215,919 | line line liquid chromatographi mass spectrometri method immobil bio macromolecul drug screen natur sourc natur product import sourc major compound drug discoveri current rapid screen identif bioactiv compound challeng due complic chemic composit natur product affin screen method base liquid chromatographi coupl mass spectrometri seen increas interest past year review various strategi classifi line line mode principl applic screen method magnet nanoparticl affin solid phase extract immobil liposom chromatographi cell membran chromatographi introduc review cover research advanc lc ms base screen method mid discuss advantag disadvantag provid outlook futur field | D008081;D001688 | T121;T109;T123 |
36,215,918 | relationship cypc gene polymorph recurr ischem stroke patient treat clopidogrel china meta analysi relationship cypc gene variant recurr ischem stroke patient treat clopidogrel still controversi accord avail publish literatur evalu correl cypc gene variant metabol type accord snps polymorph rs rs stroke recurr perform studi meta analysi | D000083242;D020521 | T047 |
36,215,914 | prescrib buprenorphin opioid use disord primari care survey french general practition sentinell network although opioid substitut coverag franc high patient care buprenorphin main manag general practition gps buprenorphin sale decreas sinc suggest french gps prescrib less buprenorphin yet possibl chang gp practic yet investig studi aim examin primari care gps opinion buprenorphin habit relat prescrib buprenorphin | D002047;D058005;D009293 | T121;T048;T109;T097 |
36,215,913 | oud meet novel program increas initi medic opioid use disord improv outcom hospit patient discharg skill nurs facil rate hospit medic complic opioid use disord oud rise mani patient requir post acut care skill nurs facil snfs howev access medic oud moud snfs remain low patient oud high rate patient direct discharg pdd hospit readmiss | D009293;D002047 | T121;T109;T048 |
36,215,912 | substanc use criminogen think longitudin latent class analysi veteran crimin histori object studi inform clinic practic identifi distinct subgroup us veteran crimin histori residenti mental health treatment studi character veteran patient alcohol drug use criminogen think also examin predictor outcom subgroup membership | D057237;D014728;D000075665;D019966 | T098;T048;T033 |
36,215,911 | accept feasibl outcom clinic pilot program video observ methadon take home dose covid pandem methadon one util treatment opioid use disord howev requir observ methadon dose impos barrier patient increas risk respiratori ill transmiss eg covid video observ methadon dose home could allow opioid treatment program otp offer take home dose ensur patient safeti remot observ ingest | D000086382;D009293 | T047;T067;T048 |
36,215,910 | servic provid perspect substanc use treatment need among human traffick survivor understand substanc use treatment need survivor human traffick remain underdevelop area field substanc use treatment studi assess natur substanc use among survivor type human traffick identifi treatment barrier need report human traffick servic provid one midwest major metropolitan area | D064410;D019966 | T054;T068;T048;T033 |
36,215,909 | extend longev geometr invert proxim tubul organoid studi report cellular self organ primari human renal proxim tubul epitheli cell rptec around minim matrigel scaffold produc basal apic proxim tubul organoid tubuloid tubuloid produc maintain hang drop cultur day longest cultur kind report date tubuloid upregul matur marker aquaporin aqp megalin lrp exhibit less mesenchym prolifer marker vimentin ki compar cultur also experi chang time reveal comparison gene express pattern cell cultur day day tubuloid gene express analysi immunohistochemistri reveal increas express megalin endocyt receptor direct bind uptak protein potenti assist protein uptak tubuloid includ day tubuloid uptak fluoresc albumin reveal punctat fluoresc pattern suggest function endocyt uptak receptor furthermor tubuloid releas kidney injuri molecul kim common biomark kidney injuri expos albumin dose time depend manner studi focus potenti applic model proteinur kidney diseas tubuloid may broad util studi apic proxim tubul cell access requir | D026561;D009940 | T024;T116;T192 |
36,215,905 | develop non bias phenotyp drug screen cardiomyocyt hypertrophi imag segment use deep learn number patient heart failur relat death rapid increas worldwid make major problem cardiac hypertrophi crucial preliminari step heart failur treatment yet fulli success studi establish system evalu cardiomyocyt hypertrophi use deep learn base high throughput screen system identifi drug inhibit first primari cultur cardiomyocyt neonat rat stimul angiotensin ii endothelin cellular imag captur use phase contrast microscop subsequ use deep learn model instanc segment establish system automat unbias evalu cardiomyocyt size perimet use system screen fda approv drug librari identifi drug inhibit cardiomyocyt hypertrophi focus ezetimib cholesterol absorpt inhibitor inhibit cardiomyocyt hypertrophi dose depend manner vitro addit ezetimib improv cardiac dysfunct induc pressur overload mice result suggest deep learn base system use evalu cardiomyocyt hypertrophi drug screen lead develop new treatment heart failur | D006332;D000077321;D004353;D006333 | T047;T046;T066;T062;T033 |
36,215,901 | recent progress mechan prepar applic polymer antifog coat fog solid surfac prejudici optic properti even caus hygien safeti concern except case thus antifog coat attract great interest fundament research industri applic superhydrophil superhydrophob coat main explor describ antifog field recent year hygroscop antifog coat hydrophil hydrophob parti introduc due uniqu properti review three antifog mechan review provid design strategi antifog surfac current techniqu fabric polymer antifog coat discuss depth recent progress materi structur antifog surfac briefli summar final practic applic outlook relat multifunct antifog coat mention | D011108 | T104;T122 |
36,215,884 | emiss transform behavior trace element combust cd rich coal coal combust relat endem fluorosi area southwest china long term combust low qualiti coal may releas hazard element environ caus serious environment problem phenomenon particular preval three gorg region southwest sw china cadmium cd well harm element found high enrich coal supergen environ area exist literatur behavior issu emiss transform elev trace element simul household stove combust cd rich inferior coal remain unknown studi investig emiss toxic element miner assemblag provid technic guidanc reduc pollut mean optim combust test inferior coal research may improv understand geochem characterist toxic element emiss coal combust endem diseas area purpos seri simul coal combust experi conduct reveal releas mobil distribut elev element cd rich coal combust product result show cd mo cr cu zn sb signific enrich inferior coal studi area furthermor larg amount toxic element releas fli ash environ combust process particular combust condit play import role emiss transform elev element exampl higher temperatur promot releas cd sb zn tl environ oxygen defici combust found liber cd sb tl atmospher generat complex miner assemblag lizardit calcit dolomit forsterit enstatit moreov toxic element found absorb fine particl matter fli ash endem fluorosi area sw china find work may aid control emiss toxic element inferior coal mitig effect toxic element environ protect human health | D003031;D014131 | T167;T121;T109;T123;T196 |
36,215,883 | inhibit nf b pathway erk mediat mitochondri apoptot pathway take part mitig effect betulin acid inflamm oxid stress cyclophosphamid trigger renal damag mice betulin acid ba occur pentacycl triterpenoid various biolog activ anti inflamm antioxid previous studi found ba attenu cyclophosphamid cyp induc intestin mucos damag inhibit intestin mucos barrier dysfunct cell apoptosi howev effect regul mechan ba cyp induc renal damag report literatur found ba pretreat allevi elev serum urea level inhibit increas serum neutrophil gelatinas associ lipocalin level induc cyp meanwhil ba amelior renal tubular epitheli cell edema vacuol renal cortic tubular renal glomerulus moreov pretreat ba inhibit mrna express pro inflammatori cytokin interleukin il il tumor necrosi factor increas mrna express anti inflammatori cytokin il transform growth factor inactiv nuclear factor kappa b simultan ba decreas accumul reactiv oxygen speci malondialdehyd lower level superoxid dismutas glutathion increas activ glutathion peroxidas cyp induc kidney damag mice besid ba reduc phosphoryl extracellular signal regul kinas erk inhibit ratio bcl bax cell apoptosi cyp trigger kidney damag furthermor ba andor pd inhibitor erk regul mitig cyp elicit renal injuri deactiv erk pathway mitochondri apoptot pathway indic protect effect ba cyp induc renal damag may associ regul erk mediat mitochondri apoptot pathway thus ba could candid agent chemotherapi drug induc nephrotox reduc inflamm oxid stress suppress erk mediat mitochondri apoptot pathway | D016328;D048049 | T126;T116;T129 |
36,215,882 | phthalat plastic decreas prion like protein doppel essenti structur integr function spermatozoa di n butyl phthalat dbp well known endocrin disruptor caus male reproduct dysfunct understand under mechan perform histolog endocrinolog biochem analys assess express gene involv spermatogenesi sperm function accord oecd test guidelin follow day administr lowest observ advers effect level dose dbp mice signific chang bodi weight testi epididymi weight histolog serum testosteron level testicular daili sperm product found nonetheless motil epididym sperm dbp group signific decreas togeth increas incid bent tail abnorm head test dbp group lipid peroxid lpo level signific increas testicular bcl mrna level signific decreas togeth increas baxbcl mrna ratio test dbp group level prnd mrna protein pouf mrna activ prnd promotor signific decreas note prion like protein doppel prnd signific decreas togeth decreas prnd immunoreact head midpiec tail sperm test dbp group level sox sgp sgp mrna function sertoli cell marker signific decreas level amh mrna sertoli cell immatur marker signific increas togeth inha mrna suggest deregul brain gonad axi togeth find suggest dbp present dosag may potenti lpo generat sertoli cell immatur via downregul sox disrupt pouf prnd gene network post meiotic germ cell without visibl chang spermatogenesi testosteron level may result structur function abnorm spermatozoa addit find suggest assess male reproduct toxic phthalat ester plastic base convent oecd test guidelin reconsid | D010968;D011328 | T005;T116;T122 |
36,215,881 | effect differ color polyethylen mulch film bacteri communiti soil enrich incub studi shown mulch agricultur field plastic residu influenc microbi communiti environ studi investig differ soil microbi communiti distinct area mulch differ color plastic product thus studi explor differ color polyethylen mulch film pmfs might affect soil bacteri communiti enrich incub found signific differ bacteri communiti differ color pmfs incub treatment color pmf obtain similar bacteri communiti composit instanc class level gammaproteobacteria bacteroidia abund black pmf wherea actinobacteria bacteroidia abund white pmf abund genera acinetobact chryseobacterium black pmf rhodanobact paenarthrobact white pmf polyethylen hydrocarbon degrad bacteria core member detect treatment bacteri communiti predict potenti biodegrad metabol xenobiot enrich cultur accord phylogenet investig communiti reconstruct unobserv state picrust tool addit bacteri communiti soil xinjiang treat white pmf soil yangl treat black pmf strong correl stabl result suggest color pmf appli affect soil bacteri communiti plastic color may recruit similar speci microorgan although origin microorgan | D012987;D020959 | T167;T109;T122 |
36,215,880 | transcriptom analysi reveal gene express chang basidiomycet yeast apiotrichum mycotoxinivoran respons ochratoxin exposur ochratoxin ota one common deleteri mycotoxin found food feedstuff worldwid howev apiotrichum mycotoxinivoran detoxifi ota result show mycotoxinivoran gum effici degrad ota caus accumul intracellular reactiv oxygen speci main aim studi identifi potenti ota detoxifi enzym explor effect ota mycotoxinivoran gmu rna seq data reveal gene signific upregul downregul respect ota exposur function enrich analys indic ota exposur enhanc defens capabl protein transport endocytosi energi metabol caus ribosom stress suppress dna replic transcript inhibit cell growth divis promot cell death integr secretom gene express molecular dock analys reveal two carboxypeptidas homologu member metallocarboxypeptidas famili like respons detoxif extracellular intracellular ota superoxid dismutas catalas main gene activ respons oxid stress addit analysi key gene associ cell divis apoptosi show ota exposur inhibit mitosi promot cell death studi reveal possibl ota respons detoxif mechan mycotoxinivoran | D009793;D001487 | T109;T131;T004 |
36,215,879 | renew eco friend zno immobil onto dead sea spong float materi dual practic aspect enhanc photocatalysi disinfect applic studi investig role natur dead sea spong dss porifera three dimension porous host substrat immobil nanostructur zno materi toward develop zno base float photocatalyst effici remov methylen blue mb dye illumin sunlight photodegrad treat water dye degrad contain sever pathogen differ disinfect chemic reagent essenti use case dss natur kill pathogen wastewat treatment process explor function zno nanosheet incorpor onto dss via hydrotherm protocol prepar znodss hybrid materi exhibit approxim degrad effici remov mb import degrad kinet associ fabric znodss remark acceler evidenc high valu degrad reaction rate constant min outperform znodss could attribut adsorpt caus porous structur togeth high rapid oxid mb furthermor high charg separ electron hole pair natur poros abund catalyt site offer hybrid znodss float photocatalyst enabl quantit degrad effici mb final excel reusabl result confirm feasibl use natur znodss base photocatalyst practic solut wastewat treatment environment problem | D015034 | T121;T197 |
36,215,878 | quantif cyclic amp cyclic gmp level kreb henseleit solut lc msms applic wash platelet aggreg sampl cyclic nucleotid import regul platelet function increas cyclic adenosin monophosph camp cyclic guanosin monophosph cgmp inhibit platelet aggreg pharmacolog target antiplatelet therapi report improv method determin camp cgmp concentr first time wash platelet supernat combin high perform liquid chromatographi tandem mass spectrometri lc msms characterist peak substrat cgmp camp intern standard identifi negat ion electrospray ionis use multipl reaction monitor compar previous report method method present show high precis lowest lower limit quantif lloq date pgml effect novel catecholamin nitrodopamin cyclic nucleotid level quantifi result show new method fast sensit high reproduc | D006152;D000242 | T121;T123;T114 |
36,215,877 | valid applic quantit lc msms assay analysi first line anti tuberculosi drug rifabutin metabolit human breast milk breast milk prefer method infant nutrit breastfeed infant born mother treat tb may risk drug toxic breast milk exposur potenti vulner select drug resist low level drug exposur except isoniazid quantif first line tb drug includ rifabutin breast milk previous describ provid much need insight tb drug exposur breastfeed infant develop valid novel method quantifi sever first line tb drug major metabolit breast milk accuraci precis assess three consecut independ valid batch calibr rang gml isoniazid ethambutol gml acetyl isoniazid desacetyl rifampicin rifampicin pyrazinamid gml rifabutin gml deacetyl rifabutin breast milk method reproduc analyt use breast milk six differ sourc influenc matrix effect mean regress precis cv rang averag recoveri analyt matrix cv averag process effici cv although acetyl isoniazid isoniazid ethambutol pyrazinamid success assay breast milk sampl taken mother treat rifampicin resist tb inclus first line tb drug includ rifabutin assay develop valid process allow futur quantif analyt breast milk | D000995;D007538 | T121;T109 |
36,215,870 | astragalin mitig inflammatori osteolysi negat modul osteoclastogenesi via ros mapk signal pathway inflammatori bone destruct gradual attract attent worldwid observ sever kind patholog bone diseas osteoarthr osteomyel rheumat arthriti infecti clinic trial skelet system regard excess osteoclast bone resorpt activ particip osteolyt process thus negat modul osteoclast differenti bone eros consid effect therapeut strategi limit poor progress inflammatori osteolysi astragalin ast bioactiv compon tradit chines drug rosa agresti present anti inflammatori antioxid effect howev unclear ast may play essenti role regul dynam balanc bone matrix affect osteoclastogenesi studi found ast could inhibit osteoclast format bone resorpt activ dose depend manner without cytotox administr ast also inhibit express cathepsin k c fos nfatc trap differ stage mrna protein level osteoclastogenesi reactiv oxygen speci ros signal could also modul treatment ast rankl induc osteoclast differenti nrf ho signal pathway addit ast could negat regul mitogen activ protein kinas mapk signal process vivo ast signific reduc lipopolysaccharid lps induc bone loss osteolyt mous model ast might promis therapeut candid treat osteolyt bone diseas futur | D010014;D001862 | T042;T046 |
36,215,869 | tumor associ macrophag lymphoma mechan therapi lymphoma common hematolog malign tumor origin lymph node lymphoid tissu tumor microenviron tme play indispens role tumorigenesi tumor develop metastasi relaps drug resist macrophag consid critic immun cell tme influenc develop tumor particular like tumor associ macrophag tam promot lymphoma growth worsen patient prognosi owe import role lymphoma tam hold promis biomark target tumor immunotherapi review summar origin recruit polar function mechan action tam lymphoma identifi potenti therapeut target strategi patient lymphoma | D000084582;D008223 | T191;T025 |
36,215,867 | handgrip strength measur protocol caus caus specif mortal outcom million particip systemat review meta regress analysi handgrip strength strong predictor risk mortal object systemat review analys handgrip strength measur protocol use caus caus specif mortal studi | D018737;D009369 | T191;T081;T040 |
36,215,866 | visual bodi composit assess method compart model comparison smartphon base artifici intellig bodi composit estim healthi adult visual bodi composit vbc estim produc smartphon base artifici intellig repres user friend conveni way autom bodi composit remot without inher geograph monetari restrict bodi composit method howev limit studi assess reliabl agreement method thus aim studi evalu vbc estim compar compart c criterion model | D000068997;D001185 | T090;T066;T073 |
36,215,865 | influenc type electrod assess bodi composit bioelectr imped analysi supin posit main sourc error bodi composit assess bedridden patient bioelectr imped analysi bia electrod inadequaci placement electrocardiogram ecg electrod often use bia measur studi aim compar three refer bia electrod | D001823 | T032 |
36,215,864 | standardis surviv excess life year lost patient type intestin failur long term outcom report home parenter nutrit hpn depend patient type intestin failur limit surviv data standardis general popul would help provid meaning prognosi patient clinician primari aim studi therefor investig surviv hpn depend patient evalu specif impact type life expect standardis general popul | D000090124;D016331;D012778 | T061;T047 |
36,215,863 | glim nurs home practic implic paper describ malnutrit preval rate accord global leadership initi malnutrit glim criteria nurs home like due practic reason miss data bodi composit dietari intak acut diseaseinflamm | D009752;D044342 | T047;T033 |
36,215,854 | synthesi anticanc activ novel histon deacetylas inhibitor inhibit autophagi induc apoptosi combin histon deacetylas hdac autophagi inhibitor consid novel cancer therapeut strategi find novel hdac inhibitor inhibit autophagi sever new seri oxazol thiazol base hdac inhibitor design synthes replac phenyl cap saha phenyloxazol phenylthiazol repres oxazol deriv compound show better enzymat inhibitori activ saha vorinostat compound induc gm cell cycl arrest antiprolif activ fold better saha multipl tumor cell line western blot analysi show compound mark increas acetyl level tubulin histon h histon h contrari saha compound found inhibit autophagi addit compound induc cell apoptosi via baxbcl caspas pathway ultim compound exhibit higher oral antitumor potenc saha xenograft model result indic compound may develop promis anticanc agent | D056572;D000970 | T121;T109;T126;T116 |
36,215,844 | electrocatalyt hydrodechlorin system antisc anti chlorin poison featur salt laden wastewat treatment high salin coexist scale ion ca mg hco wastewat challeng efficaci durabl palladium pd mediat electrocatalyt hydrodechlorin ehdc reaction chlorin organ pollut detoxif due accompani cl poison pd site scale electrod concentr nacl solut g l ca mg l mg mg l hco mg l ehdc effici pd toward dichlorophenol decreas signific h reaction electrod cover layer fluffi aragonit precipit herein demonstr inclus commerci antiscal phosphonobutan tricarboxyl acid pbtc prevent scale format cl poison lead effici steadi ehdc process mechanist studi reveal uniqu dual function pbtc primarili origin bear phosphon carboxyl group larg affin group especi phosphon group scale cation pd pbtc chelat stabil scale cation water replac cl pd surfac also releas proton trigger format electron defici pd speci via pbtc pd bind lead enhanc ehdc work provid effect solut scalingpoison issu common encount real wastewat pave solid road ehdc applic pollut abat | D018508;D004785;D063065 | T057;T131;T109;T052 |
36,215,843 | understand point use tap water qualiti instrument measur intellig analysi use sampl filtrat case point use tap water qualiti routin monitor due wide dispers sampl site cost test although previous studi reveal variat drink water qualiti distribut municip network influenc age pipe build qualiti still unknown make difficult water util conduct regular mainten herein undertaken survey tap water sampl across district beij china evalu potenti effect pipe age point use water qualiti includ turbid organ matter characterist bacteri communiti group collect sampl accord pipe age sourc water respect result suggest bacteri divers signific influenc pipe age howev bacteri communiti structur clear influenc sourc water similar age pipe build also respons deterior final water qualiti effect close link select water qualiti paramet evalu relev factor moreov interrelationship physico chemic paramet bacteria abund identifi exampl ph ca mg na k show posit relationship bacillus abund addit intellig analysi method understand pipe age organ matter concentr hard ie ca mg concentr base imag analysi filter membran develop accuraci predict encourag improv collect data tap water sampl expect method exploit public monitor tap water provid feasibl cost effect approach water supplier locat agingdeterior pipe need replac maintain | D060753;D060766 | T167;T033 |
36,215,842 | ammonium remov recoveri municip wastewat ion exchang use metakaolin k base geopolym among avail technolog ammonium remov wastewat ion exchang repres one promis one perspect recov ammonium produc fertil product howev vast major previous studi ammonium ion exchang evalu process robust real oper condit optim desorpt step paper test ammonium remov recoveri conduct metakaolin k base geopolym compar high perform italian natur zeolit k form real municip salin wastewat treat continu flow pilot plant equip cm adsorpt bed bed volum ml sorbent mass g empti bed contact time min geopolym granul show higher perform term select toward ammonium oper capac mg n g dri adsorb inlet concentr mg n l bed volum wastewat treat select breakpoint geopolym result cost effect adsorb wastewat treatment capabl adsorb cation ion exchang allow fraction desorpt procedur led recov ammonium solut compos main nh wt kno wt potenti usabl fertil geopolym robust assess repeat adsorptionregener cycl show geopolym mechan morpholog properti deterior result make test geopolym promis materi optim scale ammonium recoveri process circular economi perspect | D064751;D017641 | T104;T197 |
36,215,841 | catalyt remov attach tetrabromobisphenol microplast surfac biochar activ oxid impact potenti disinfect product format numer studi concern impact widespread microplast pollut ecolog environ show synergist effect microplast co expos pollut risk enhanc howev control method remov harm pollut microplast surfac reduc ecolog toxic rare explor paper magnet graphit biochar catalyst shown achiev remov tetrabromobisphenol tbbpa microplast biochar mediat electron transfer chang surfac structur microplast caus various age process affect pollut attach subsequ remov effici chlorin highest disinfect product dbp generat potenti observ group microplast attach tbbpa oxid system biochar activ peroxodisulf pds reduc kind dbps also great reduc total amount detect dbps well reduc overal toxic paper highlight overlook contribut pollut attach potenti risk dbp generat natur microplast chlorin process provid under insight guid design biochar base catalyst wast achiev remov tbbpa microplast reduc risk hazard co contamin | D000080545;D014874 | T131;T122 |
36,215,840 | insight co host nitrat reduct gene antibiot resist gene urban river qinghai tibet plateau microbi co host nitrat reduct gene nrgs antibiot resist gene arg recent report ecolog biochem role urban waterway remain larg unknown collect surfac water sediment sampl huangshui river qinghai tibet plateau wet dri season water sampl wastewat treatment plant wetland along river use metagenom sequenc retriev medium high qualiti metagenom assembl genom mag nrg arg co host main belong phyla proteobacteria actinobacteriota bacteroidota microorgan carri arg high proport also encod nrgs support nitrat reduc bacteria domin host arg season chang antibiot level correspond signific variat relat abund nrg arg co host water sediment result concomit chang antibiot resist pathway contrast contribut nrg arg co host nitrat reduct stabl season identifi specif antibiot eg sulphonamid microbi taxa eg acinetobact hafnia may disproportion impact relationship serv basi laboratori investig bioremedi strategi studi suggest high abund nitrat reduc microorgan contamin environ may also direct impact human health carrier antibiot resist | D045483;D000900 | T121;T195;T070 |
36,215,839 | tetracyclin photolysi revisit overlook day night success parent compound metabolit natur surfac water associ ecotox despit extens studi tetracyclin photolysi aquat environ phototransform tetracyclin metabolit natur day night success examin studi investig tetracyclin photolysi associ ecotox two natur surfac water one artifici ultrapur water simul daynight cycl two day previous unrecogn high ph temperatur depend dark interconvers tetracyclin metabolit observ liquid chromatographi mass spectrometrymass spectrometri analysi identifi rang isomer hydroxyl demethyl deamin open ring photoproduct hydrolysi tetracyclin isotetracyclin sever intermedi product propos major mechan observ dark transform exposur studi employ escherichia coli indic although tetracyclin degrad product lower bacteri toxic parent compound increas toxic irradi time near complet degrad parent compound natur water impli product mixtur retain ecotox dark transform also affect bacteri toxic fluoresc properti irradi tetracyclin solut overal studi provid new insight photochem behavior tetracyclin associ ecolog risk aquat environ | D014874 | T131 |
36,215,838 | posit feedback dewater wast activ sludg condit process fe ii catalyz urea hydrogen peroxid treatment dispos sludg complex environment problem high moistur content herein report process fe ii activ urea hydrogen peroxid uhp improv wast activ sludg dewater first time fe ii uhp proven signific improv dewater specif optim condit fe ii uhp mgg tss cst srf wc sc reduc mkg control mkg respect analysi reveal oh generat fe ii uhp system play domin role enhanc dewater oh found attack extracellular polymer substanc epss cell caus epss fragment decomposit part epss micro molecul organ even inorgan lead cell destruct thus liber epss bound cell bound water oh also degrad protein centrifug liquor cl micro molecul organ amino acid could reduc viscos electroneg cl fact ultim reduc solid liquid interfac interact increas hydrophob floccul flowabl meanwhil broken floc floccul via adsorpt bridg charg neutral induc fe ii fe iii moreov fe ii uhp treatment achiev reduct stabil heavi metal dewat sludg enabl land applic final fe ii uhp process found attract fe ii persulf classic fenton process cpam term cost save practic implement | D012722;D014865 | T069;T057 |
36,215,837 | electrochem iron product enhanc anaerob membran treatment wastewat although iron salt iron iii chlorid fecl widespread applic wastewat treatment safeti concern limit use due corros natur concentr solut studi demonstr local electrochem generat iron viabl altern use iron salt three laboratori system anaerob membran process set treat real wastewat two system use product either situ ex situ electrochem iron fe fe fe respect system serv control system oper one year assess impact electrochem produc iron system perform result show dose electrochem iron signific reduc sulfid concentr effluent hydrogen sulfid content bioga mitig organ base membran foul critic issu inher relat sustain anaerob wastewat treatment electrochem iron strategi generat multipl benefit wastewat manag includ increas remov effici total volatil suspend solid chemic oxygen demand phosphorus rate methan product also increas electrochem produc iron econom analysi reveal viabil electrochem iron total cost reduc one quarter third compar use fecl benefit indic electrochem iron dose great enhanc overal oper perform anaerob membran process particular facilit wastewat manag decentr scenario | D006862;D002424 | T131;T130;T197 |
36,215,836 | refin estim amphetamin consumpt wastewat base epidemiolog consumpt amphetamin methamphetamin two common illicit drug monitor wastewat base epidemiolog wbe mani countri past decad potenti estim amount amphetamin use skew locat methamphetamin also consum amphetamin also excret wastewat follow methamphetamin consumpt present studi aim review avail data literatur identifi averag ratio amphetaminemethamphetamin ampmeth excret wastewat methamphetamin consumpt ratio could use refin estim amphetamin consumpt catchment amphetamin methamphetamin use use data wastewat sampl australia methamphetamin domin illicit amphetamin type substanc market abl subtract contribut legal sourc amphetamin contribut obtain median ampmeth ratio wastewat use valu amphetamin deriv methamphetamin consumpt calcul subtract total amphetamin mass load wastewat sampl without consid contribut amphetamin methamphetamin use select european catchment compar consumpt amphetamin methamphetamin show overestim amphetamin use catchment ampmeth ratio greater impact amphetamin methamphetamin would neglig catchment ampmeth ratio rang difficult accur estim amphetamin consumpt | D013287;D008694;D014874 | T121;T109;T131 |
36,215,835 | natur sourc zone deplet nszd insight year research measur multi site studi site averag natur sourc zone deplet nszd rate measur petroleum light non aqueous phase liquid lnapl sourc zone site compil research project report scientif paper site follow data compil general site locat ii lnapl fuel type iii measur method number locat number measur per locat iv calcul site averag nszd rate liter per hectar per year lhayr per site associ measur method ie gradient method carbon trap dynam close chamber dcc thermal monitor result dataset show site averag nszd rate rang lhayr gallon per acr per year galacreyr median valu lhayr galacreyr median site averag nszd rate type fuel spill show statist signific differ fuel type compar differ nszd measur method appli site site averag nszd rate differ time ie ratio faster rate slower rate median differ time clear bias observ nszd rate measur method four site calcul nszd rate season nszd rate typic higher summer fall compar winter spring site q valu measur increas nszd rate associ c increas temperatur rang median implic studi suggest increas mean annual soil temperatur site use engin method could potenti increas biodegrad rate eg increas c could doubl nszd rate final five site site averag nszd rate multipl year averag nszd rate vari time across year overal evalu nszd rate measur lnapl site suggest measur nszd occur across broad rang lnapl site although nszd rate vari across site fuel type primari factor explain observ differ rate | D010578 | T109 |
36,215,834 | microplast trap dam reservoir driven complex hydrosedimentari process villerest reservoir loir river franc dam reservoir strong influenc spatial distribut sediment pollut microplast mp villerest reservoir loir river km long good candid studi relationship mp pollut hydrosedimentari process sediment collect dam control river section km downstream geomorpholog sedimentolog analys perform microplast analys use ftir imag polym identif particl size paper highlight strong mp level order itemskg dw section character fine grain sediment fgs coars grain sediment cgs upstream part reservoir downstream dam level one order magnitud lower fgs indic long time settl process condit lead foster mp trap low densiti suspend materi water column cgs deposit origin river bed load sediment transport high veloc high turbul flow condit moreov post deposit rework finest fraction occur accord hydrofluctu advers condit mp trap polym divers also higher fgs cgs howev rang plastic particl size similar fgs cgs relat sediment grain size distribut moreov fgs cgs polym abund correl grain size distribut organ matter content reservoir context chang polym partit appear fgs section downstream direct depend polym densiti fundament point view work contribut improv understand key role play hydrosedimentari process mp repartit find also oper scope provid signific element advoc better consider mp pollut sediment manag oper | D000080545;D014874 | T131;T122 |
36,215,833 | biomass retent microbi segreg offset impact season temperatur pilot scale integr fix film activ sludg partial nitrit anammox ifa pna treat anaerob pretreat municip wastewat partial nitrit anammox pna promis deammonif process develop energi neutral wastewat treatment plant howev mainstream applic pna still face challeng low nitrogen concentr low temperatur studi realist condit larg scale reactor kilolit level real municip wastewat mww season temperatur research pilot scale one stage pna integr fix film activ sludg ifa configur oper treat real mww pretreat anaerob membran bioreactor remov effici total nitrogen tn c correspond effluent tn mgl respect suppress ammonium oxid bacteria aob anammox bacteria anaob occur lower temperatur signific decreas aob treatment capac reason poorer nitrogen remov c biomass retent microbi segreg success achiev specif candidatusbrocadia candidatuskuenenia main anaob genera main enrich carrier nitrosomona uncultur fchitinophagacea main aob genera main distribut suspend sludg retain sediment tank moreov nitrit oxid bacteria nob suffici suppress intermitt aerat low dissolv oxygen presenc heterotroph bacteria upgrad pna simultan partial nitrit anammox denitrif cod oxid snadco system improv overal remov tn cod result investig clear evid strong feasibl pna mainstream nitrogen remov process temper climat | D012722;D064751 | T069;T104;T197 |
36,215,832 | treatment bromat uvsulfit autoxid process enhanc format dibromoacetonitril chlorin integr uvsulfit autoxid process usap ie uv activ sulfit presenc mgl convent water degrad micropollut rise extens attent impact water qualiti especi format disinfect byproduct still unclear herein format dibromoacetonitril dban bromat bro upon treatment usap follow chlorin evalu presenc amino acid aa select repres organ matter drink water result reveal hydrat electron e aq produc usap contribut reduct bro br convert hbrobro post chlorin time sulfat radic hydroxyl radic oh generat usap mediat aa convers via hydrogen abstract nh hydrogen abstract reaction produc hnc ch cooh ch chnh ch cn releas post chlorin stage therefor enhanc bromin util factor buf valu dban format effect usap treatment time bro concentr aa concentr ph real water also evalu although bro elimin usap follow chlorin toxic index ti increas fold due format bromin cx r type nitrogen disinfect byproduct n dbps demonstr potenti risk appli usap treatment process bro contain water | D018508;D060766;D014874;D004202 | T057;T131;T167;T052 |
36,215,831 | effect modifi atkin diet adult drug resist epilepsi control studi object studi proof concept analysi strategi assess effect modifi atkin diet mad adult drug resist epilepsi dre retrospect cohort studi includ particip age year least two fail antiseizur medic asm variabl self report gather medic record phone call two group compar mad adjuv asm diet group asm control make group compar diet control group match predictor seizur remiss psr adult dre systemat review literatur conduct establish psr total patient elig forti six particip initi mad continu diet month number past new asm epilepsi type follow time select psr twelv patient includ diet group control group match psr compar control group diet group greater odd achiev seizur frequenc reduct month confid interv mean seizur frequenc secondari outcom differ signific group summari mad show modest effect seizur control compar asm match psr could altern analysi approach determin effect ketogen diet control studi addit studi requir valid analysi propos | D000076107;D000069279;D055423;D004827 | T061;T047;T033 |
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