PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,216,777 | social isol suicid risk literatur review perspect suicid major public health problem caus prematur mortal view prevent great deal research devot determin suicid focus most individu risk factor particular depress addit caus intrins individu social environ also wide studi particular social isol paper examin social dimens suicid etiolog review literatur relationship suicid social isol | D013405 | T033 |
36,216,767 | independ risk factor affect hemorrhag percutan nephrolithotomi retrospect studi periop postop concern percutan nephrolithotomi pnl bleed diseas relat condit stone size stone hu tract number diamet affect situat determin determin independ risk factor may affect amount hemorrhag pnl | D000074642;D058226 | T031;T061;T046;T020 |
36,216,762 | systemat review meta analysi ck cd ki p immunohistochem marker bladder carcinoma situ urotheli dysplasia carcinoma situ cis relat recurr progress urotheli carcinoma differenti cis dysplasia reactiv atypia often difficult base histolog featur integr histolog find immunohistochemistri use routin practic make diagnosi cis purpos immunohistochem marker ck cd ki p use supplement histolog work aim assess ck cd ki p immunohistochem marker patient cis systemat review meta analysi | D002278;D002295;D001749 | T191 |
36,216,725 | comparison disabl common mental disord sever mental disord use whoda mental disord among lead caus disabl worldwid despit fact sever mental disord smd associ high disabl impact common mental disord cmd neglig work compar disabl measur whoda scale diagnost group mental health nurs facil | D001523;D006233 | T101;T048 |
36,216,719 | link nutrient sens mitochondri function prr immun cell signal liver diseas calor overconsumpt vertebr promot adipos liver fat accumul perturb gut microbiom triad trigger pattern recognit receptor prr mediat immun cell signal steril inflamm moreov immun system activ perpetu metabol consequ includ progress nonalcohol fatti liver diseas nafld nonalcohol hepat steatohepat nash recent find show sens nutrient overabund disrupt activ homeostasi central cellular energi generat organell mitochondrion parallel whether calor excess initi prr signal mitochondri perturb coordin amplifi inflammatori process nash progress remain question hypothes alter mitochondri function classic prr signal complement activ respons nutrient overload togeth play integr role across immun cell landscap lead liver inflamm nash progress | D065626 | T047 |
36,216,717 | cut edg interleukin prompt hif wound heal il wide consid inflammatori cytokin link develop sever autoimmun diseas inflammatori bowel diseas psoriasi howev recent report konieczni et al shed light novel protect role il wound heal ad grow list studi highlight noninflammatori function il | D011565;D001327 | T047 |
36,216,716 | bet b cell exacerb obes relat metabol diseas b cell associ develop obes associ metabol diseas recent hgglf vanz et al identifi novel obes relat subset b cell demarc transcript factor bet pathogen abil worsen metabol diseas outcom | D020825;D008659 | T047;T116 |
36,216,703 | preoper high frequenc color doppler ultrasound assess blood vessel fibular myocutan flap fibular myocutan flap classic flap use reconstruct oral maxillofaci defect studi aim evalu effect high frequenc color doppler ultrasound detect blood vessel fibular myocutan flap analyz influenc variat peron vessel perfor peron arteri surgic design explor valu technolog preoper assess blood vessel fibular myocutan flap | D064827;D019651;D061525 | T061;T023;T024 |
36,216,702 | preliminari report augment realiti assist craniofaci bone fractur reduct zygomaticomaxillari complex fractur involv four fractur end difficult fulli expos oper area main coron incis intraor incis eyelid incis address partial visual field loss craniofaci fractur reduct attempt use augment realiti ar navig system | D000081411;D025321;D050723 | T061;T170;T037 |
36,216,675 | intermedi length cgg repeat expans notchnlc associ patholog confirm alzheim diseas alzheim diseas ad common caus dementia elder patholog character amyloid plaqu neurofibrillari tangl sever gene found relat ad includ human specif notch n termin like c notchnlc gene cgg repeat expans notchnlc report clinic diagnos ad patient howev report patholog confirm ad case studi detect notchnlc cgg repeat expans patholog confirm ad brain sampl repeat prime pcr rp pcr fluoresc amplicon length analysi pcr al pcr result intermedi length cgg repeat expans notchnlc valid one patholog confirm ad case patholog p posit intranuclear inclus observ wide brain area inclus appear present glial cell summari studi found intermedi length cgg repeat expans notchnlc associ patholog confirm ad p posit intranuclear inclus could co exist ad neuropatholog chang data suggest associ notchnlc cgg repeat expans ad may stronger previous studi | D000544 | T047;T048 |
36,216,651 | shade doubt measur classifi vaccin confid europ anti vaccin movement vaccin hesit waver vaccin confid increas becom matter public interest parallel increas normal represent vaccin riski studi use data vaccin belief behavior two eurobaromet survey classifi attitud toward vaccin discuss compar acquiesc measur issu cluster analysi found individu european union eu classifi five opinion type differenti pole vaccin trust vaccin distrust hesit free choic cluster two relat uncommit cluster agreeabl acquiesc fenc sitter opinion configur vaccin link broader social structur age gender educ attain experi adult vaccin trust differ inform sourc found trust distrust confus vaccin permeat social strata eu countri pandem year amplifi uncertainti concern vaccin safeti effect also notic decreas trust voic mainstream medic expert pandem period signific increas peopl declar nt know trust vaccin inform rang measur vaccin confid europ control acquiesc posit negat formul item ensur compar time strong recommend inclus batteri critic item futur european commiss fund survey vaccin allow monitor european public confid vaccin relev inform sourc includ trust pharmaceut compani provid avenu establish broader confid among citizen health author specialist | D007722;D014612 | T121;T053;T116;T129 |
36,216,650 | immunogen safeti high dose quadrival influenza vaccin older adult taiwan phase iii random multi center studi high dose influenza vaccin offer better protect influenzaassoci complic compar standard dose formul evalu immunogen safeti high dose influenza vaccin qiv hd standard dose qiv sd older adult year taiwan | D007252;D007251;D053118 | T047;T121;T109;T129;T005 |
36,216,649 | effect matern pertussi vaccin singapor test negat case control studi pertussi vaccin tdap tetanus diphtheria acellular pertussi pregnant women recommend sinc novemb singapor prospect test negat case control studi aim evalu vaccin effect pertussi infect pertussi relat intens care unit icu admiss accord tdap tetanus diphtheria acellular pertussi pregnanc andor infant pertussi vaccin total children case control recruit icu admiss median age month interquartil rang iqr month overal mother receiv antenat tdap vaccin infant receiv pertussi vaccin major dose tdap pregnanc alon without infant vaccin infant dose confid interv ci ci respect pertussi infect ci ci respect icu admiss conclus matern tdap vaccin high protect infant pertussi routin recommend pregnant women | D014917;D022681;D004165;D013742 | T121;T047;T129 |
36,216,648 | counsel non communic diseas patient covid vaccin uptak jordan evalu intervent peopl noncommunic diseas ncds signific higher risk worst outcom infect covid thus amongst main target popul vaccin despit priorit vaccin number vaccin patient comorbid stall post vaccin introduct despit govern along partner ran nation awar campaign ramp vaccin coverag coverag remain suboptim thus one one health counsel initi implement explor accept covid vaccin ncds patient address main issu surround vaccin hesit studi evalu impact intervent analyz chang covid vaccin accept | D000073296;D000086382;D014612 | T047;T116;T121;T129;T067 |
36,216,647 | covid outbreak elder care home low vaccin effect late impact booster vaccin campaign elder peopl long term care facil ltcf higher risk sever covid yet evid vaccin effect popul scarc novemb delta period covid outbreak occur ltcf netherland continu despit measur booster vaccin campaign investig outbreak assess primari covid vaccin sar cov infect mortal describ impact booster vaccin | D000086382 | T047;T067 |
36,216,615 | assess benthic macroinvertebr potenti bioindic anthropogen disturb southeast bangladesh coast mani human activ great influenc alter health aquat ecosystem regard quantit analysi macroinvertebr relationship ecolog variabl effect method environment monitor program use benthic macroinvertebr communiti bioindic assess anthropogen impact coastal water southeast bangladesh sediment sampl collect season three differ site influenc either mangrov forest aquacultur activ sewag input indic valu index indval analysi reveal speci benthic macroinvertebr potenti bioindic name enigmonia aenigmatica mactra chinensi pharella javanica class bivalvia tubifex tubifex class clitellata lithopoma brevispina bullia vittata pomacea maculata umbonium vestiarium class gastropoda gammarus roeselii class malacostraca amphictei gunneri amphitrit ornata aricidea simplex cirratulus cirratus heterospio catalinensi hypereteon foliosa lopadorrhynchus henseni neanth chingrighattensi micronephthi oligobranchia nephti hombergii nerei jacksoni nerei zonata polyodont maxillosus stygocapitella subterranean class polychaeta composit across three site vari signific p due influenc environment condit infer redund analysi polychaeta gastropoda malacostraca suscept sewag input bivalvia clitellata suscept aquacultur effluent result baselin studi suggest identifi benthic macroinvertebr speci potenti use monitor anthropogen disturb marin environ | D007448;D017753 | T082;T070;T204 |
36,216,600 | li atick theori effici binocular code tutori mini review li atick network comput neural system present theori effici binocular encod explain number experiment find binocular neuron convent describ term two channel left right eye li atick theori instead describ neuron term two altern channel binocular sum differ advantag latter descript unlik left right eye channel summat differenc channel usual uncorrel mean channel optimis independ theori show deriv optim recept field binocular summat differenc channel easi deriv neuron optim left right eye recept field function realiti summat differenc channel demonstr seri adapt studi confirm counterintuit predict theori provid access account theori review evid support | D015348;D009474 | T025;T041 |
36,216,599 | long term medic outcom live kidney donor histor minim risk live kidney donor high select healthi oper risk well defin yet concern remain long term risk general popul even mild reduct glomerular filtrat rate gfr associ cardiovascular diseas chronic kidney diseas end stage kidney diseas eskd howev reduct gfr general popul due kidney system diseas retrospect studi compar donor match general popul control found increas donor risk prospect studi compar donor control maximum follow year report donor gfr stabl increas slight wherea gfr decreas control howev studi identifi metabol vascular donor abnorm retrospect studi compar donor control limit select control group statist analys andor length follow one studi report increas donor mortal report small increas absolut risk eskd risk factor donor eskd similar general popul postdon pregnanc also associ increas risk hypertens preeclampsia critic need long term follow studi compar donor control era geograph area socioeconom status healthi normal renal function date match date donat match demograph characterist donor data need optim donor candid counsel inform consent | D016030;D007676 | T061;T047 |
36,216,595 | cellscaffold model base align electrospun nanofib filmhydrogel multilay construct anisotrop engin tissu mani tissu three dimension anisotrop structur compat physiolog function engin vitro tissu natur structur function hotspot tissu engin applic tissu regener drug screen diseas model despit various design success guid cellular align could precis control orient layer multilay construct achiev adequ cell contact layer studi propos design multilay cellscaffold model cell load align nanofib filmhydrogel anfgel model character cell load anfgel model term design construct morpholog cell behavior systemat studi anf produc effici align electrospin use self design fast easi collector design base parallel electrod modifi larger gap area cm nanofib generat simpl devic present numer featur like high orient uniform fiber diamet thin anfgel base cellscaffold model form encapsul cell load multilay poli lactic co glycol acid anf hydrogel cell within anfgel model show high viabil display align orient elong accord nanofib orient film form multilay tissu layer space studi provid multilay cellscaffold model vitro construct anisotrop engin tissu exhibit potenti applic cardiac tissu engin | D057139;D023822 | T061;T073 |
36,216,522 | child neurolog famili hemophagocyt lymphohistiocytosi under isol cns inflamm enceph encephalopathi children repres diagnost challeng describ patient relaps enceph differenti diagnosi includ acut dissemin encephalomyel human herpesvirus enceph hemophagocyt lymphohistiocytosi hlh rariti hlh often overlook differenti diagnosi enceph especi isol cns form case illustr inborn error immun underli isol enceph includ differenti diagnosi present | D001927;D004660;D051359;D009462 | T047;T091 |
36,216,518 | csf alzheim diseas biomark time vari relationship mci symptom onset associ age sex apo studi aim examin whether baselin csf measur alzheim diseas ad relat patholog associ time onset mild cognit impair mci whether associ differ age sex apolipoprotein e apo status proxim year vs distal year time symptom onset | D000544;D060825 | T047;T048 |
36,216,516 | exploratori meta analysi hypox transcriptom use precis transcript refer sequenc set gene express studi intrins bias mani studi influenc concomit inform gene diseas associ limit overcom use data driven analysi approach without reli ancillari inform fantom cage associ transcriptom project provid comprehens meta assembl human transcriptom use code noncod gene hypoxia strong influenc gene express addit noncod rna ncrna metabol regul respons hypox stimuli evalu differenti respons various transcript hypoxia determin hypoxia respons score enrich analysi reveal sever gene associ ncrna metabol particular involv ribosom rna process regul respons hypoxia previous publish inform fantom cage associ transcriptom project suitabl meta analysi transcriptom sequenc data code ncrnas evalu hypoxia respons target transcript relationship sens antisens transcript locus result may facilit function annot various transcript includ ncrnas allow sens antisens code noncod evalu | D022661;D059467 | T081;T086;T114 |
36,216,515 | vegfr modul brain microvessel branch mous model q delet syndrom loss singl copi tbx account clinic sign symptom q delet syndrom common genet disord character multipl congenit anomali brain relat clinic problem like vascular origin tbx mutant mice brain vascular anomali thus make use model gain insight human diseas found main morphogenet function tbx mous brain suppress vessel branch morphogenesi regul vegfr demonstr inactiv vegfr tbx express domain tbx mutant background enhanc brain vessel branch filopodia format wherea increas vegfr express domain fulli rescu phenotyp similar result obtain use vitro model endotheli tubulogenesi overal result studi provid genet evid vegfr regul earli vessel branch filopodia format mous brain like mediat brain vascular phenotyp caus tbx loss function | D004062 | T047 |
36,216,513 | cut edg neutrophil licens matur monocyt effect antifung effector neutrophil critic direct erad aspergillus fumigatus conidia whether mediat antifung defens beyond role effector unclear studi demonstr neutrophil deplet impair activ protect antifung ccr inflammatori monocyt absenc neutrophil monocyt display limit differenti monocyt deriv dendrit cell reduc format reactiv oxygen speci diminish conidiacid activ upstream regul analysi transcript respons monocyt predict loss stat depend signal potenti basi dysfunct seen neutrophil deplet mice find condit remov stat ccr cell result diminish antifung monocyt respons wherea exogen administr ifn neutrophil deplet mice restor monocyt deriv dendrit cell matur reactiv oxygen speci product altogeth find support critic role neutrophil antifung immun effector also import contributor antifung monocyt activ part regul stat depend function | D009000;D009504 | T025 |
36,216,512 | mechan cda cdb support igm b cell fit b cell receptor surfac express bcr consist surfac bound ig heterodimer signal unit compris cda cdb upon cognat ag recognit receptor initi import signal b cell develop function receptor also convey ag independ surviv signal term tonic signal although requir cdacdb heterodim bcr complex assembl surfac express well establish base mice model studi investig human matur b cell studi found human tonsillar b cell high surfac express igm igg potenti bcr signal compar bcr low cell high igm express germin center b cell associ reduc apoptosi explor mechan igm surfac express crisprca induc delet cda cdb four b lymphoma cell line delet either cd protein caus loss surfac igm cell line reduc fit three two cell line generat stabl cda cdb knockout clone demonstr loss cda cdb caus block n glycan matur accumul immatur protein compat retent bcr compon endoplasm reticulum rescu experi cdb wild type restor surfac express cda igm matur glycosyl wherea natur occur cdb gs mutant disrupt cdacdb heterodimer studi highlight cda cdb requir surfac igm express human b cell illumin import igm express level signal fit | D015703;D011947 | T192;T116;T129 |
36,216,507 | uniform isotrop cytoskelet tile fill dendrit spine dendrit spine submicron subcellular compart whose shape defin actin filament associ protein accur map cytoskeleton challeng given small size compon remain unclear whether actin associ structur analyz dendrit spine neuron vitro appli dendrit spine intact matur neuron situ combin advanc prepar method multitilt serial section electron microscopi em tomographi comput analysi reveal full three dimension intern architectur spine intact brain male mice nanomet resolut compar hippocamp ca pyramid cell cerebellar purkinj cell term length distribut connect filament branch angl absolut orient elementari loop form network despit differ shape size across spine spine head neck intern organ remark similar neuron type larg homogen throughout spine volum tortuous mesh high branch interconnect filament branch exhibit prefer orient except immedi vicin cell membran found new filament preferenti split convex side bend filament consist behavior arp mediat branch actin mechan deform base quantit analysi spine cytoskeleton like subject consider mechan forc situ | D049229;D000199 | T026;T123;T116 |
36,216,506 | oral sensori neuron genicul ganglion express tyrosin hydroxylas compris subpopul contact type ii type iii tast bud cell oral sensori neuron genicul ganglion gg innerv tast papilla bud tongu soft palat electrophysiolog record neuron fiber reveal complex number uniqu respons profil observ suggest sever distinct neuron subtyp molecular descript subpopul incomplet report identif subpopul gg oral sensori neuron mice express tyrosin hydroxylas th th express genicul neuron repres oral sensori neuron neuron innerv tast bud fungiform anterior foliat tast papilla surfac tongu well tast bud soft palat tast bud tongu innerv th neuron soft palat tast bud innerv neuron extragemm process outsid tast bud express mechanosensori neuron associ gene ret suggest chemosensori somatosensori neuron within tast bud th express fiber contact type ii type iii cell rais possibl respons one tast qualiti analysi also identifi rare th tast receptor cell type found tast bud co express trpm suggest type ii cell taken togeth th express gg oral sensori neuron innerv tast bud preferenti soft palat contact type ii type iii tast bud receptor cell | D013650 | T023 |
36,216,505 | perinat morphin exposur lead sex depend execut function deficit microgli chang mice children expos prenat opioid increas risk behavior problem execut function deficit prefront cortex pfc amygdala amg regul execut function social behavior sensit opioid prenat opioid bind toll like receptor tlr activ microglia may development import synapt prune therefor test effect perinat morphin exposur execut function social behavior male femal mous offspr along microgli relat synapt relat outcom dam inject daili subcutan salin n morphin mo mgkg n throughout pregest gestat lactat offspr wean postnat day p male mo offspr impair attent accuraci five choic serial reaction time task femal mo offspr less affect target gene express analysi p pfc identifi alter microgli relat tlr relat gene immunohistochem analysi adult brain indic decreas microgli iba phagocyt cd protein pfc amg male femal increas male femal mo offspr increas social prefer overal data demonstr male vulner execut function deficit respons perinat opioid exposur evid disrupt neuron microgli signal | D056344;D017628;D009020;D011297;D012737 | T037;T121;T041;T109;T102;T025 |
36,216,493 | sodium glucos cotransport inhibitor amput risk fractur risk sodium glucos cotransport sglt inhibitor associ cardiovascular renal benefit across broad rang patient increas total serious advers event evalu evid respect amput fractur risk drug class overal sglt inhibitor associ increas risk amput fractur patient popul test increas amput fractur risk canagliflozin observ canagliflozin cardiovascular assess studi canva program seen canagliflozin renal event diabet establish nephropathi clinic evalu trial studi sglt inhibitor extens evalu amput fractur risk suggest canva program find chanc observ rather real effect | D000671;D000068896;D050723;D000077203 | T121;T061;T109;T037 |
36,216,492 | sglt inhibitor safeti older patient sglt inhibitor sglti effect manag diabet reduc advers cardiovascular renal outcom random clinic trial demonstr safeti toler older adult advers effect associ sglti impact patient frailti comorbid concomit medic use therefor must thorough evalu initi treatment risk volum deplet hypoglycemia genit infect diabet ketoacidosi minim appropri patient select patient educ earli symptom recognit limit data exist regard risk urinari tract infect fractur amput elder treat sglti routin monitor recommend | D003924;D016883;D007003;D000077203 | T121;T047;T109 |
36,216,491 | sodium glucos cotransport inhibitor nonalcohol fatti liver diseas nonalcohol fatti liver diseas nafld system disord cardiovascular manifest due complex multifactori pathophysiolog mechan effect pharmacolog treatment identifi date sodium glucos cotransport sglt inhibitor demonstr potenti favor effect nafld incid progress preclin clinic studi review summar evid preclin human studi support use sglt inhibitor nafld propos sever mechan may drive favor effect ie increas insulin sensit decreas intrahepat fat accumul lipotox decreas oxid stress endoplasm reticulum er stress improv autophagi inhibit apoptosi | D065626;D000077203 | T121;T047;T109 |
36,216,490 | sglt inhibitor peripher vascular event review literatur fifti articl compris random control trial rcts observ studi meta analys safeti effect sodium glucos cotransport inhibitor evalu current review one fourth cohort recent trial peripher arteri diseas pad wherea subgroup high risk amput despit remark heterogen rcts trial canagliflozin suggest excess amput rate wherea sever observ studi generat conflict conclus remain short possibl explan preliminari evid observ research suggest patient pad may even benefit sglt inhibitor treatment due lower observ heart failur hospit rate | D003924;D000077203 | T121;T047;T109 |
36,216,489 | sodium glucos cotransport inhibitor impact atherosclerosi atherosclerot cardiovascular diseas event sodium glucos cotransport inhibitor sglt improv risk heart kidney failur howev effect major atherosclerot cardiovascular event mace less clear although outcom trial drug diabet power prove superior total trial data yield estim relat reduct mace hr ci neutral stroke hr ci anim model sglt favor affect plaqu size composit inflammatori pathway human data regard lack ongo trial evalu sglt efficaci heart failur kidney diseas postmyocardi infarct popul independ diabet status | D050197;D002318;D003924;D000077203 | T121;T047;T046;T109 |
36,216,488 | sglt inhibitor heart failur earli initi achiev rapid clinic benefit sodium glucos cotransport inhibitor sglti recent addit pillar medic therapi heart failur hf reduc eject fraction improv qualiti life morbid mortal benefit evid within first day initi review discuss rational sglti initi simultan rapid sequenc guidelin direct medic therapi gdmt also discuss sglti use earli benefit hf patient eject fraction greater | D003924;D006333;D000077203 | T121;T047;T046;T109 |
36,216,487 | sglt inhibitor heart failur preserv eject fraction trial slgt inhibitor type diabet suggest potenti benefit drug patient heart failur random trial confirm benefit heart failur reduc eject fraction attent turn heart failur preserv eject fraction hfpef emperor preserv trial sglt inhibitor empagliflozin reduc risk cardiovascular death hospit heart failur hr ci p driven reduct worsen hf event sglt inhibitor like becom new standard care patient hfpef | D003924;D006333;D000077203 | T121;T047;T046;T109 |
36,216,486 | sglt inhibitor heart failur reduc eject fraction paradigm shift toward dual cardio renal protect sodium glucos transport inhibitor sglti found effect prevent heart failur patient diabet chronic kidney diseas without cardiovascular diseas recent evid suggest sglti substanti improv cardiovascular renal outcom patient heart failur reduc eject fraction hfref review discuss combin cardio renal benefit sglti patient hfref addit discuss impact renoprotect midterm manag hfref possibl implement strategi initi sglti routin care hfref | D003924;D006333;D000077203 | T121;T047;T046;T109 |
36,216,485 | sglt inhibitor type diabet mellitus sodium glucos cotransport inhibitor first discov glucos lower drug glycosur action good safeti profil subsequ studi cardiovascular outcom trial peopl type diabet cardiovascular benefit consist observ regard heart failur hospit cardiovascular death investig under mechan grant benefit continu engag research world find describ articl pave way larger use drug patient heart failur aim improv clinic outcom qualiti life | D002318;D003924;D006333;D000077203 | T121;T047;T046;T109 |
36,216,484 | renoprotect effect sglt inhibitor sglt inhibitor protect kidney patient without type diabet fail includ blood glucos depend independ mechan sglt inhibitor lower glomerular pressur filtrat therebi reduc physic stress filtrat barrier oxygen demand tubular reabsorpt improv cortic oxygen togeth lesser tubular glucotox improv mitochondri function autophagi reduc proinflammatori profibrot signal preserv tubular function gfr long term shift transport downstream sglt inhibitor may mimic system hypoxia stimul erythropoiesi improv oxygen deliveri kidney organ | D003924;D003928;D000077203 | T121;T047;T109 |
36,216,483 | glucos lower metabol effect sglt inhibitor sodium glucos cotransport sglt inhibitor consist demonstr improv outcom patient heart failur without type diabet howev mechan contribut benefit remain poor understood although sglt inhibitor glucos lower effect unlik cardiovascular benefit sole due improv glycem control improv glycemia lead consequ metabol effect could provid explan action review discuss glucos lower metabol effect sglt inhibitor might lead improv cardiovascular outcom patient heart failur | D002318;D003924;D006333;D000077203 | T121;T047;T046;T109 |
36,216,458 | prevent oxid damag spinal cord ischemia upon aortic surgeri first human result shock wave therapi prove safeti feasibl background spinal cord ischemia sci remain devast complic aortic dissect repair primari hypox damag follow secondari damag result cellular loss via apoptosi affect patient poor prognosi limit therapeut option shock wave therapi swt improv function outcom neuron degener surviv murin spinal cord injuri first human studi treat patient spinal cord ischemia swt aim prove safeti feasibl method result human neuron subject ischem injuri subsequ swt reactiv oxygen speci cellular apoptosi quantifi use flow cytometri signal antioxid transcript factor nrf nuclear factor erythroid relat factor immun receptor toll like receptor tlr analyz assess whether swt act via conserv mechan transgen tlr zebrafish creat via crisprca subject spinal cord injuri translat find clinic set patient sci underw swt baselin analysi follow month includ assess american spinal cord injuri associ asia impair scale evalu spinal cord independ measur score world health organ qualiti life questionnair swt reduc number reactiv oxygen speci posit cell apoptosi upon ischemia via induct antioxid factor nuclear factor erythroid relat factor inhibit delet tlr impair axon growth spinal cord lesion zebrafish wherea tlr stimul enhanc spinal regener first human studi treat patient sci use swt mean age year four patient present acut aortic dissect exhibit preoper neurolog symptom impair asia patient asia b patient asia patient baselin follow patient grade asia patient asia b spinal cord independ measur score show signific improv examin world health organ qualiti life questionnair reveal increas score follow conclus swt reduc oxid damag upon sci via immun receptor tlr first human applic prove safeti feasibl patient sci swt could therefor becom power regen treatment option devast injuri | D000074059;D020760;D013119;D000784 | T050;T047;T046;T037;T061 |
36,216,453 | assur safeti dental materi use applic standard formal histori standard dentistri unit state goe back world war prompt govern need buy larg quantiti dental materi treat armi teeth disrepair articl cover use scientif research establish specif standard use evalu dental materi product practition use standard assur safeti perform materi use everyday practic | D003764 | T122 |
36,216,452 | biomateri periodont regener widespread chronic diseas periodont progress destroy tooth support structur periodontium eventu lead tooth loss therefor regener damagedlost periodont tissu major subject periodont research periodont tissu regener biomateri play pivot role improv outcom periodont therapi advanc biomateri scienc engin recent year new biomimet materi scaffold fabric technolog propos periodont tissu regener articl summar recent progress periodont tissu regener biomateri perspect first various guid tissu regenerationguid bone regener membran graft biomateri periodont tissu regener overview next recent develop multifunct scaffold biomateri alveolar boneperiodont ligamentcementum regener summar final clinic care point perspect use biomimet scaffold materi reconstruct hierarch periodont tissu provid | D001672;D016557 | T061;T122 |
36,216,451 | regener dental pulp scaffold materi approach novel technolog platform allow signific breakthrough dental pulp tissu engin develop inject scaffold combin stem cell growth factor bioactiv compound enabl regener function dental pulp abl secret dentin preclin clinic studi similar cell home technolog scaffold free strategi aim modul dental pulp self regener mediat resid stem cell evad technic challeng relat cell base tissu engin strategi articl discuss emerg technolog platform clinic applic dental pulp tissu engin | D003782;D023822;D054457 | T061;T023;T122 |
36,216,450 | dental implant enhanc biolog respons surfac modif surfac characterist import factor long term clinic success dental implant alter implant surfac characterist acceler improv osseointegr interact physiolog bone heal dental implant surfac tradit modifi microlevel recent research activ investig nano modif dental implant review explor implant surfac modif enhanc biolog respons interfac bone implant | D015921 | T074 |
36,216,449 | current protocol resin bond dental ceram resin bond ceram restor common treatment option clinic longev resin bond ceram restor depend qualiti durabl resin ceram bond type composit specif ceram determin select effect bond protocol protocol typic includ surfac pretreat step follow applic prime agent understand fundament ceram properti chemic composit enabl clinician make proper materi select decis clinic success long last restor base research accru past decad articl review discuss current resin bond protocol common use dental ceram | D001840;D019279 | T061;T122 |
36,216,448 | advanc ceram dental applic purpos studi present current dental ceram materi process method clinic indic emphas basi materi microstructur composit studi ceram character also discuss impact clinic indic serv paramet develop new materi novel strategi most found aim mimic natur dental structur provid mechan reliabl develop predict restor term adapt design | D003776;D015040 | T196;T122 |
36,216,447 | digit technolog restor dentistri although accuraci direct digit oral structur improv indirect digit still requir specif situat full arch scan accur imag import effici design achiev cad softwar although smile design use dimension facial scan better predict plan restor improv virtual articul need complex case comput aid manufactur offer sever format chairsid laboratori central fabric subtract techniqu main use restor mani chairsid cam materi avail addit techniqu potenti save materi advantag fabric complex geometri limit evid avail appli cadcam technolog implant restor howev use fabric custom implant abut crown various materi titanium zirconia peek hybrid crown use stock titanium base abut | D000082222;D014025 | T090;T196;T073 |
36,216,446 | bioactiv restor dental materi new frontier bioactiv materi dental resin restor rise field investig explor treatment strategi reduc recurr carious lesion current effort direct toward develop dental materi inhibit biofilm prevent tooth miner loss bioactiv resin materi shown potenti interfer polymicrobi consortia vivo help maintain lifespan restor | D003188;D003731 | T047;T122;T033 |
36,216,445 | dental light cure assess blue light hazard articl focus current understand concern blue light hazard use dental light cure unit also provid inform safeti protocol guid practition make import decis regard dental personnel health qualiti dental restor | D055117;D055115 | T061;T074 |
36,216,444 | resin base composit direct indirect restor clinic applic recent advanc futur trend continu advanc resin base composit make select appropri system daunt task clinician review aim simplifi process clarifi new controversi topic various type composit direct indirect applic discuss includ microfil microhybrid composit nanocomposit singl shade bulk fill fiber reinforc high temperaturehigh pressur process cadcam three dimension printabl composit recent materi advanc lead improv seal tough degrad resist antimicrobi self heal capabl present futur direct highlight develop smart materi abl interact host environ | D003188;D003764 | T122 |
36,216,443 | dental adhes surfac modif dentin structur stabl bond latest advanc dentin bond focus strategi impair degrad mechan order extend longev bond interfac proteas inhibitor reduc collagen degrad within hybrid layer hl collagen cross linker allow better adhes infiltr also inhibit proteas activ particl ad adhes promot miner precipit within hl reduc nanoleakag microperm besid possibl antimicrobi enzymat inhibit effect approach still experiment aspect adhes clinician control still determin long term stabil adhes restor | D001840;D017220 | T061;T122 |
36,216,442 | implement feder waiver feed children earli care educ covid pandem captur child adult care food program cacfp state director experi implement feder waiver feed children earli care educ ece set coronavirus diseas | D000086382;D002656 | T073;T047;T092;T067 |
36,216,441 | inform infant nutrit time infant formula advic infant formula choic prepar first month life examin sourc time advic formula feed parent receiv factor influenc choic formula product formula prepar | D041943;D014001 | T168;T123;T196 |
36,216,438 | progress simultan right left atrial remodel uncov comprehens magnet reson assess atrial fibril background left atrial structur remodel contribut arrhythmogen substrat atrial fibril af role right atrium ra remain unknown aim comprehens character right atrial structur remodel af identifi right atrial paramet predict recurr ablat method result late gadolinium enhanc cardiac magnet reson obtain individu healthi volunt patient af undergo ablat right left atrial volum surfac spheric quantifi right atrial global region fibrosi burden assess valid threshold patient af systemat follow ablat recurr progress right atrial dilat increas spheric observ healthi volunt patient paroxysm persist af fibrosi similar among group correl paramet recapitul right atrial remodel mild subsequ remodel atria compar ra larger left atrium la group fibrosi burden higher la ra patient af wherea spheric higher la patient persist af fibrosi volum surfac ra la spheric strong correl tricuspid regurgit predict right atrial volum shape wherea diabet associ right atrial fibrosi burden sex persist af also predict right atrial volum fibrosi ra most locat inferior vena cava ra junction right atrial spheric signific associ af recurr ablat hazard ratio ci conclus af progress associ right atrial remodel parallel la right atrial spheric yield prognost signific ablat | D064752;D001281;D017115 | T061;T047;T046 |
36,216,437 | machin learn approach predict hospit mortal patient admit peripher arteri diseas unit state background peripher arteri diseas pad affect million peopl unit state pad associ poor outcom includ prematur death machin learn ml increas use big data predict clinic outcom studi aim develop ml model predict hospit mortal patient hospit pad base nation databas method result inpati hospit data obtain nation inpati sampl total inpati identifi primari diagnosi pad pad relat procedur use code intern classif diseas tenth revis clinic modif icd cm intern classif diseas tenth revis procedur code system icd pcs four ml model includ logist regress random forest light gradient boost extrem gradient boost model train predict risk hospit death base select variabl includ patient characterist comorbid procedur hospit relat factor hospit mortal occur patient perform model compar area receiv oper characterist curv rang sensit specif result suggest adequ predict clinic decis make model total number diagnos procedur age endovascular revascular procedur congest heart failur diabet diabet complic critic predictor hospit mortal conclus studi demonstr feasibl ml predict hospit mortal patient primari pad diagnosi find highlight potenti ml model identifi high risk patient poor outcom guid person intervent | D058729;D057510;D008171;D003920 | T061;T047 |
36,216,435 | physiolog base superior apolipoprotein b low densiti lipoprotein cholesterol non high densiti lipoprotein cholesterol marker cardiovascular risk european societi cardiologyeuropean atherosclerosi societi state apolipoprotein b apob accur marker cardiovascular risk low densiti lipoprotein cholesterol ldl c non high densiti lipoprotein cholesterol sinc evid continu mount favor apob review explic physiolog mechan respons superior apob marker cardiovascular risk attribut atherogen apob lipoprotein particl chylomicron remnant low densiti lipoprotein low densiti lipoprotein particl first natur relat number differ apob particl outlin make clear low densiti lipoprotein particl almost alway major determin cardiovascular risk concentr triglycerid ldl c may obscur relat next mechan govern number low densiti lipoprotein low densiti lipoprotein particl outlin except dysbetalipoproteinemia total number apob particl determin cardiovascular risk mechan govern cholesterol mass within low densiti lipoprotein low densiti lipoprotein particl review respons discord mass cholesterol within apob particl measur either ldl c non high densiti lipoprotein cholesterol number apob particl measur apob creat superior predict power apob ldl c non high densiti lipoprotein cholesterol final major apob dyslipoproteinemia briefli outlin object provid physiolog framework health care giver understand apob accur marker cardiovascular risk ldl c non high densiti lipoprotein cholesterol | D002318;D050197 | T047;T046 |
36,216,434 | prognost impact nutrit status transcathet edg edg mitral valv repair mivnut registri background malnutrit associ poor prognosi sever cardiovascular diseas howev prognost impact patient undergo transcathet edg edg mitral valv repair teer well known studi sought assess preval clinic associ prognost consequ malnutrit patient undergo teer method result total patient undergo teer intern mivnut mitral valv repair nutrit status registri studi malnutrit status assess control nutrit status score associ nutrit status mortal analyz multivari cox regress model wherea associ heart failur admiss assess fine gray model death compet risk accord control nutrit status score patient teer degre malnutrit time teer patient bodi mass index kgm bodi mass index kgm howev moder sever malnutrit teer success patient median follow year interquartil rang patient die patient admit heart failur teer compar normal nutrit status moder sever malnutrit result strong predictor mortal adjust hazard ratio hr ci p heart failur admiss adjust subdistribut hr ci p conclus malnutrit common among patient submit teer moder sever malnutrit strong associ increas mortal heart failur readmiss assess nutrit status patient may help improv risk stratif | D044342;D006333;D008944;D019918 | T061;T047;T046 |
36,216,433 | nt routin check vaccin background adult nation qualit studi barrier facilit vaccin deliveri uptak adult migrant uk primari care explor primari care profession view around barriersfacilit catch vaccin adult migrant foreign born year age incompleteuncertain vaccin status routin vaccin inform develop intervent improv vaccin uptak coverag | D014171;D014612 | T098;T121;T116;T129 |
36,216,432 | haemoglobin transfus threshold traumat brain injuri optimis hemot multicentr randomis clinic trial protocol traumat brain injuri tbi lead caus mortal long term disabl young adult despit high preval anaemia red blood cell transfus patient tbi optim haemoglobin hb transfus threshold unknown undertook randomis trial evalu whether liber transfus strategi improv clinic outcom compar restrict strategi | D000070642;D011788 | T078;T037 |
36,216,431 | protocol guo aortic arch reconstruct prospect multicentr singl arm studi evalu safeti efficaci weflow arch modular inner branch stent graft system aortic arch lesion giant studi endovascular repair entir aortic arch provid treatment opportun patient aortic arch lesion intoler open surgeri howev complex anatom configur high speed blood flow long access femor arteri increas difficulti endovascular aortic arch repair basi earlier studi new modular inner branch stent graft system develop specif lesion locat aortic arch part ascend aorta studi aim evalu safeti efficaci novel modular branch stent graft system patient aortic arch lesion unsuit open aortic arch replac | D017545;D057510 | T061;T047 |
36,216,430 | tofa predict studi protocol stratif trial determin key immunolog factor predict tofacitinib efficaci drug free remiss psoriat arthriti psa psoriat arthriti psa chronic inflammatori musculoskelet diseas affect patient psoriasi current challeng clinic care research includ personalis treatment understand diverg therapi respons unravel multifactori pathophysiolog complex diseas moreov urgent clinic need predict assess understand cellular molecular pathway under respons diseas modifi antirheumat drug dmard tofa predict clinic trial address need primari object determin key immunolog factor predict tofacitinib efficaci drug free remiss psa | D018501;D015535;D010880;D011743 | T047;T121;T109;T123;T114 |
36,216,429 | ambul employe seek organis help mental health support mix method systemat review protocol organis support avail barriersfacilit uptak covid pandem exacerb wide rang symptom poor mental health among emerg medic servic em ambul popul evid suggest use organis support improv employe outcom turn patient outcom understand em staff use support servic therefor critic improv uptak ensur equit access potenti influenc workforc well organis sustain patient care deliveri systemat review aim identifi support avail perceiv barrier facilit access utilis organis support | D000086382;D008603 | T047;T041;T067 |
36,216,428 | food insecur level depress among patient chronic diseas associ factor covid lockdown cross section studi rural rwanda aim describ access food symptom depress among patient chronic diseas caregiv assess associ factor covid lockdown rural rwanda | D000086382 | T047;T067 |
36,216,427 | public support car smoke ban poland nation cross section survey object studi assess preval self report secondhand smoke exposur car among adult poland characteris public attitud toward implement ban smoke car children | D061845;D014028 | T069;T064;T033 |
36,216,426 | randomis control trial hand surgeri scope review identifi evid gap exist regard efficaci effect hand surgeri | D006225 | T023 |
36,216,425 | preterm deliveri associ factor among mother bangladesh survey rajshahi district preterm deliveri pd worldwid health burden particular low incom middl incom countri bangladesh key indic neonat mortal risk morbid later life studi aim determin preval pd associ factor among mother northern region bangladesh | D047928 | T046 |
36,216,424 | unit kingdom earli detect initi uk edi protocol establish nation multicentr cohort individu new onset diabet earli detect pancreat cancer pancreat cancer lead caus cancer death worldwid screen diseas potenti improv surviv feasibl current screen modal screen asymptomat adult popul howev screen individu high risk group recommend studi aim provid resourc data inform strategi screen individu new onset diabet nod pancreat cancer | D003920;D010190 | T191;T047 |
36,216,423 | habit health visitor deliv advic britain infant toothbrush earli phase feasibl studi complex oral health intervent conduct earli phase feasibl studi oral health intervent health visitor deliv advic britain infant toothbrush habit deliv health visitor parent children age month old | D064691;D014099 | T061;T097 |
36,216,422 | purpos life ikigai employ status relat cardiovascular mortal japan collabor cohort studi investig whether purpos life ikigai associ risk cardiovascular diseas cvd mortal whether associ vari employ status | D002318;D004651 | T098;T047;T080;T033 |
36,216,421 | burnout cope strategi among nurs malaysia nation level cross section studi nation level studi aim determin preval risk factor burnout well cope strategi among nurs ministri health moh malaysia | D002055 | T048 |
36,216,420 | associ covid incid postpon cancel elect surgeri japan septemb cross section web base survey studi aim examin whether covid pandem affect postpon cancel elect surgeri japan | D000086382 | T047;T067 |
36,216,419 | understand racialis older adult experi canadian healthcar system codesign solut protocol qualit studi nine languag racialis immigr older adult rioa canada poorer self rate health like report chronic condit concurr experi well document challeng navig access healthcar system strong evid patient caregiv engag healthcar lead improv manag chronic diseas better health outcom intern research suggest engag potenti reduc health dispar improv qualiti care aim describ role rioa arear take healthcar perspect particip group rioa caregiv healthcar provid hcps develop codesign process particip creat linguist align cultur align tool resourc solut support patient engag rioa | D007802;D010358 | T058;T081;T171;T080 |
36,216,418 | posit whole exom sequenc diagnost pathway rare diseas optimis util protocol observ cohort studi econom evalu despit superior diagnost perform exom genom sequenc compar convent genet test evid gap relat clinic util cost effect limit avail routin clinic practic mani jurisdict inform adopt reimburs polici protocol provid chain evid approach determin diagnost util clinic util cost effect whole exom sequenc wes seven medic genet centr two canadian provinc | D005820;D035583 | T059;T047;T060 |
36,216,417 | multicentr narrat research major depress integr experi patient caregiv healthcar provid itali research aim investig experi major depress integr perspect patient caregiv healthcar provid narrat base medicin nbm provid new insight improv care relationship | D017028;D003865 | T098;T097;T099;T048 |
36,216,416 | earli onset burdensom multimorbid exploratori analysi sentinel condit condit accrual sequenc durat three long term condit use british cohort studi preval multipl long term condit ltc multimorbid increas younger onset among socioeconom depriv popul research life cours trajectori toward multimorbid limit earli onset multimorbid poor characteris understand sentinel condit first ltc occur life cours sequenc ltc accrual perman report ltcs may help identifi time point prevent effort use longitudin birth cohort estim preval common three condit earli onset multimorbid multipl long term condit multimorbid mltc group midlif describ frequenc sentinel condit sequenc ltc accrual explor perman one condit psycholog distress | D006973;D000079225 | T047;T048 |
36,216,415 | studi patient staff experi investig percept target key interact improv scope review improv patient experi pe relat experi staff care yet littl evid interact matter patient staff perceiv aim summaris interact percept patient staff studi use patient staff experi data healthcar institut | D003695;D006268 | T093;T058;T073 |
36,216,414 | usabl dual hivsyphili self test among men sex men china studi protocol three arm randomis control trial hiv self test hivst provid key measur earli detect hiv infect men sex men msm howev dual hivsyphili self test msm popul studi describ randomis control trial evalu effect dual hivsyphili self test test frequenc among msm china | D015658;D000072339;D013587 | T098;T047 |
36,216,413 | effect augment realiti activ video game gait train children cerebr palsi follow singl event multilevel surgeri protocol randomis control trial paediatr rehabilit fun motiv also critic key success therapi varieti intervent shown posit effect high level interest complianc engag activ video game avg seem interest approach postop gait rehabilit children cerebr palsi cp studi investig overground gait train gt deliv avg improv walk capac anaerob perform | D000081411;D002547;D018910 | T047;T170;T073;T019 |
36,216,410 | paus methotrex prevent impair omicron ba ba neutralis covid booster vaccin level neutralis capac omicron ba ba third covid vaccin patient paus continu methotrex mtx therapi unclear | D018501;D000086382;D014612 | T047;T116;T121;T129;T067 |
36,216,409 | reduc humor respons third dose booster sar cov mrna vaccin concomit methotrex therapi elder patient rheumatoid arthriti sever health author recommend third booster vaccin protect patient rheumat musculoskelet diseas sever covid methotrex shown reduc efficaci first second dose sar cov mrna vaccin far remain unknown concomit methotrex affect efficaci covid booster vaccin | D001172;D000086382;D000086663;D056724;D008727 | T047;T121;T109;T040;T200;T043;T067 |
36,216,402 | respiratori function ct abnorm among survivor covid pneumonia nationwid follow studi consid pulmonari burden caus acut covid question remain respiratori consequ recoveri aim studi describ respiratori function covid pneumonia survivor mid term follow median day assess whether impair predict acut ill sever residu ct abnorm | D000086382 | T047;T067 |
36,216,401 | patient survey examin experi care hospit base opt tobacco depend treatment servic cure project treat tobacco depend patient admit hospit key prioriti nation health servic long term plan servic evalu assess percept need experi care within opt hospit base tobacco depend treatment servic convers understand replac expert evid base cure team north west england | D000086382;D016540 | T055;T047;T067 |
36,216,384 | manag chronic migrain chronic migrain neurolog disord associ consider disabl lost product profound econom burden worldwid past five year seen dramat expans new treatment often challeng condit among calcitonin gene relat peptid antagonist neuromodulatori devic review outlin epidemiolog diagnost criteria risk factor chronic migrain discuss evid base drug non drug treatment advantag disadvantag principl patient center care adult chronic migrain attent differenti diagnosi comorbid clinic reason initi monitor cost avail discuss intern guidelin drug treatment chronic migrain evalu non drug treatment includ behavior complementari therapi lifestyl modif final discuss manag chronic migrain special popul includ pediatr pregnanc older peopl consid futur question emerg research field | D008881 | T047 |
36,216,376 | case steroid refractori dengu myositi respons intraven immunoglobulin dengu arbovirus infect usual present symptom high grade fever myalgia rash dengu spread aed aegypti mosquito frequent outbreak report region like pakistan india sri lanka although muscl ach quit common dengu fever overt myositi rare occurr report case young girl present us serolog confirm dengu infect bilater upper lower limb weak rais creatin kinas along electromyographi pattern suggest myositi condit steroid resist respond intraven immunoglobulin discharg stabl condit | D003715;D009220 | T047 |
36,216,375 | develop implement evalu high qualiti virtual preoper anaesthet assess covid beyond qualiti improv report preoper risk factor identif optimis wide accept gold standard care elect surgeri essenti reduc morbid mortal covid public health restrict requir care balanc ensur best medic practic maintain safeti minimis patient face face attend hospit base success implement telemedicin tm medic specialti feasibl preoper context studi aim develop implement evalu high qualiti virtual preoper anaesthet assess process | D000777;D000086382;D017216 | T047;T058;T121;T067;T039 |
36,216,360 | light qualiti modul growth trigger differenti accumul phenol compound chang total antioxid capac red callus viti davidii light qualiti one key elicitor direct affect plant cell growth biosynthesi secondari metabolit studi red callus spine grape cultur nine light qualiti name dark white red yellow blue green purpl warm yellow warm white light effect differ light qualiti studi callus growth accumul phenol compound total antioxid capac red callus spine grape result show blue purpl light induc increas red color callus wherea yellow light induc greatest callus prolifer among light qualiti treatment dark treatment downregul content phenol compound wherea blue light treatment conduc accumul total phenol white blue purpl light induc increas anthocyanin accumul mix wavelength light benefici accumul flavonoid blue purpl light conduc accumul proanthocyanidin studi show cyanidin glucosid cyg peonidin glucosid pg main anthocyanin compon callus blue purpl white light treatment promot accumul wherea flavan ol flavonol main compon non anthocyanin phenol accumul chang respons light qualiti also cultur durat total antioxid capac callus cultur chang signific respons differ light qualiti result provid evid abiot elicitor strategi stimul callus growth enhanc accumul main phenol compound red callus spine grape | D027843;D044945 | T116;T002;T121;T109;T168;T129 |
36,216,349 | discoveri character potent efficaci oral avail antimalari plasmepsin x inhibitor preclin safeti assess ucb plasmepsin x pmx essenti aspartyl proteas control malaria parasit egress invas erythrocyt develop function liver merozoit prophylact activ block transmiss mosquito make potenti multistag drug target report optim aspartyl proteas bind scaffold discoveri potent oral activ pmx inhibitor vivo antimalari efficaci incorpor safeti evalu earli character pmx inhibitor preclud compound long human half life develop optim focus improv target safeti profil led identif ucb improv vitro vivo safeti profil shorter predict human ucb estim achiev log unit reduct asexu blood stage parasit daili dose mg day work demonstr potenti deliv pmx inhibitor vivo efficaci treat malaria | D000962;D008288;D005493 | T121;T047 |
36,216,344 | raman spectroscopi chemic biolog research chemic biolog research various fluoresc probe develop use visual target protein molecul live cell tissu yet limit technolog limit number color detect simultan recent raman spectroscopi appli chemic biolog overcom limit raman spectroscopi detect molecular vibrat reflect structur chemic condit molecul sampl origin use direct visual chemic respons endogen molecul howev initi research develop raman tag open new avenu applic raman spectroscopi chemic biolog perspect first introduc label free raman imag biomolecul illustr biolog applic raman spectroscopi next highlight applic raman imag small molecul use raman tag chemic biolog research final discuss develop potenti raman probe repres next generat probe chemic biolog | D013059;D014732 | T059;T070 |
36,216,342 | function output regress machin learn materi scienc recent year rapid growth use machin learn materi scienc convent train predict model describ scalar output variabl thermodynam electron mechan properti function input descriptor vector composit structur featur given materi molecul chemic composit crystallin system machin learn materi data hand output variabl often given function exampl predict optic absorpt spectrum molecul output variabl spectral function defin wavelength domain altern predict microstructur polym nanocomposit output variabl given imag electron microscop repres two three dimension function imag coordin system studi consid two unifi framework handl multidimension function output regress applic wide rang predict analys materi scienc first approach employ generat adversari network known exhibit outstand perform various comput vision task imag generat style transfer video generat also present anoth type statist model inspir statist methodolog refer function data analysi extens kernel regress deal function output simpl mathemat structur make effect model even small amount data demonstr propos method sever case studi materi scienc | D000074266;D000069550 | T090;T066 |
36,216,298 | draft genom multi omic analys reveal new insight geo herbal properti citrus grandi tomentosa citrus grandi tomentosa cgt huajuhong hjh wide use medicin plant main produc guangdong guangxi provinc south china particular hjh huazhou hz counti guangdong provinc well regard best nation product geo herbal reason geo herbal properti hjh hz counti remain mysteri therefor multi omic approach appli identifi natur geo herbal cgt three differ region comprehens screen differenti metabolit reveal nobiletin content signific differ hz region compar region could employ key indic determin geo herbal furthermor high qualiti genom n mb coupl genom transcriptom analys indic cgt citrus grandi close relat predict diverg time million year ago mya recent wgd occur cgt bioactiv ingredi cgt abund citrus grandi interest nobiletin polymethoxyflavon content identifi potenti indic geo herbal methyltransferas omt gene involv synthesi polymethoxyflavon multi omic analysi led identif novel omt gene ctgomt whose transient overexpress display signific higher nobiletin content suggest ctgomt involv synthesi nobiletin overal find provid new data resourc geo herbal evalu germplasm conserv insight nobiletin biosynthesi pathway medicin plant c grandi tomentosa | D002957;D010946 | T168;T002 |
36,216,297 | ala upregul mdptpa express increas ppa activ promot stomat open appl leav aminolevulin acid ala new natur plant growth regul inhibit abscis acid aba induc stomat closur studi shown protein phosphatas ppa involv ala aba antagonist regul stomat movement howev molecular mechan under remain unclear report ala promot mdppa activ mdppac express epidermi appl malus domestica borkh cv fuji leav yh yeast two hybrid bifc bimolecular fluoresc complement flc firefli luciferas complement imag assay analysi show mdppac interact mdptpa phosphortyrosyl phosphatas activ furthermor transient overexpress interfer express mdptpa transgen appl leav develop result show overexpress mdptpa promot stomat open reduc ca h increas flavonol guard cell convers mdptpa silenc transient transgen appl leav ca h flavonol guard cell stomat movement complet convers transgen appl leav exogen ala stimul ppa repress snrk activ respons wild type therefor propos mdptpa increas ppa activ mediat ala signal promot stomat open appl leav | D029681;D027845;D017360 | T168;T116;T002 |
36,216,296 | develop tobacco rattl virus base platform dual heterolog gene express crisprca reagent deliveri larg number viral deliveri system develop character function gene produc heterolog recombin protein plant unabl co express two fusion free foreign protein whole plant extend period time studi modifi tobacco rattl virus trv trve dual deliveri vector use strategi gene substitut reconstruct trve capabl simultan produc two fusion free foreign protein whole level nicotiana benthamiana maintain genet stabil insert doubl foreign gene moreov trve allow system express two foreign protein total length aa residu addit casa protein crrna deliv trve express system site direct edit genom dna n benthamiana c line constitut express green fluoresc protein gfp taker togeth trv base deliveri system simpl power mean rapid co express two non fuse foreign protein whole level facilit function genom studi plant | D064113;D010942 | T005;T040 |
36,216,295 | twin cyclic mononucleotid cyclas phosphodiesteras domain architectur common featur complex plant protein major protein prokaryot eukaryot proteom consist two function center allow intramolecular tune protein function architectur oppos anim ortholog appli plant cyclas cnc phosphodiesteras pdes vast major part larger multifunct protein plant recent two case combin cnc pde one protein report propos plant multifunct protein pde motif identifi presenc addit cnc center common search arabidopsi thaliana proteom combin pde cnc motif allow creation databas protein activ one exampl methylenetetrahydrofol dehydrogenas determin activ adenyl cyclas ac pde base biochem mutagenesi analys assess impact ac pde catalyt center dehydrogenas activ allow us propos addit regulatori mechan govern folat metabol camp therefor conceiv combin cnc pde architectur common regulatori configur control level cyclic nucleotid cnmp influenc catalyt activ protein | D010727;D010940 | T126;T116 |
36,216,288 | produc medium chain length polyhydroxyalkano divers feedstock deregul unsatur fatti acid biosynthesi escherichia coli fatti acid metabol escherichia coli serv basic metabol chassi medium chain length polyhydroxyalkano mcl pha product studi phag phac gene pseudomona entomophila l first clone pgrn e coli blp e coli bl de ptsg contain pgrn abl produc mgl homopolym poli hydroxydecano p hd glucos xylos respect next gene pseen encod putat hydroxyacyl coa ligas p entomophila l found increas perform mcl pha product induct fatti acid biosynthesi repressor fabr transcript regul repress ufa biosynthesi e coli substanti increas mcl pha product order magnitud unrel relat carbon sourc convers mcl pha concentr mgl content obtain mol hydroxyoctano ho mol hd | D054813 | T109 |
36,216,273 | perineuron net cruis honeycomb safeti net extracellular matrix ecm signific compon brain constitut brain volum perform multifari function develop matur regener central nervous system cns ecm molecul assembl systemat form relat rigid uniqu lattic like structur known perineuron net pnns pnns usual envelop cell bodi initi axon segment character mesh like structur extend along dendrit neuron pnns play promin role earli neural develop migrat differenti axon path find regul plastic regener adulthood surround stabil synapt contact review focus basic structur distribut visual pnns role critic period develop synaptogenesi regul synapt plastic furthermor also tri evalu particip pnns pathophysiolog sever brain disord potenti lower local oxid stress taken togeth concept outlin review emphas heterogen pnns respons normal physiolog patholog condit highlight need futur studi pnns target role etiolog potenti therapeut intervent neurolog disord | D005109;D009473 | T042;T043;T024 |
36,216,268 | robson ten group classif system evalu cesarean section rate hondura relev labor induct use robson ten group classif rtgc analyz cesarean section cs rate honduran matern hospit focus group consid induct labor | D002585;D007751 | T061;T079 |
36,216,213 | toward gold standard function readout character vitro lung barrier develop biomimet vitro lung model altern anim studi urgent improv predict pharmacokinet potenti new drug pharmacokinet studi advanc vitro lung model lung chip mimic function air blood barrier unlik vivo condit stemprimari cell cell line necessarili form function tight barrier cultur vitro explor two gold standard techniqu monitor barrier integr transepitheli electr resist teer permeabl discuss advantag limit method provid recommend methodolog improv elud possibl futur direct | D008168 | T023 |
36,216,209 | metabol rewir reveal cell specif rate analys nontarget exometabolom simultan consumpt glucos lactic acid cho fed batch process previous report base untarget metabolom carnitin deriv part mechan overcom impair mitochondri function trigger acyl group overflow cho cell studi analyz cell specif rate select metabolit use two metric correl coeffici root mean squar deviat rmsds glucos fed versus glucoselact acid fed cultur time cours profil acetylcarnitin adipoylcarnitin glutarylcarnitin glutam succin exhibit signific negat correl two cultur condit base rmsds seven carnitin deriv hydroxi methyl glutar mevalon pyridoxamin phosphat succin glycin substanti differ analys two metric reveal distinct rearrang rate follow metabol pathway high secret rate carnitin part acyl group remov ii low secret rate succin relat tricarboxyl acid cycl electron transport chain iii low secret rate pyridoxamin phosphat co factor amino acid catabol transamin transsulfur iv increas consumpt rate glutam glycin use produc glutathion rewir rate observ upon feed lactic acid best explain activ pathway support homeostasi acyl group antioxid synthesi requir continu proper function oxid phosphoryl | D005947;D019344 | T121;T109;T123 |
36,216,199 | safeti evalu process later root aconitum carmichaelii debx hepatotox mechan rat process later root aconitum carmichaelii debx known fuzi extens use tradit chines medicin treat cardiovascular diseas rheumat arthriti bronchiti pain hypothyroid etc although chines pharmacopeia regul safe clinic dosag fuzi gpersonday recommend lack bench evid also differenti fuzi differ process type heishunpian paofupian | D031841;D004365;D000470;D004224;D056486 | T047;T002;T037;T131;T121;T109;T123 |
36,216,198 | inhibit xbps driven lipogenesi qushi huayu decoct contribut amelior hepat steatosi induc fructos qushi huayu decoct qhd tradit chines medicin formula consist five herb use non alcohol fatti liver diseas nafld treatment clinic decad china valid sever nafld anim model hepat de novo lipogenesi dnl enhanc great contribut steatosi nafld splice form x box bind protein xbps initi dnl independ sterol regulatori element bind protein srebp carbohydr respons element bind protein chrebp | D050155;D065626 | T047;T040 |
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