PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,215,498 | doubl interpenetr nanostructur network marin polysaccharid possess properti compar synthet polym sustain circular economi requir materi possess properti profil compar synthet polym addit process sourc raw materi small environment footprint present paradigm process marin biopolym materi possess elast plastic behavior within singl system involv doubl interpenetr polym network compris elast phase dynam physic cross link stress dissip ionic cross link domain proof principl film possess twofold higher elast modulus ultim tensil strength yield stress polylact acid realiz blend two water solubl marin polysaccharid name algin acid alg physic cross linkabl carboxyl agaros ca follow ionic cross link dival cation dri caalg film show homogen nano micro scale domain yield stress size domain scale invers calcium concentr surfac activationcross link use calcium caalg film could process use wet bond yield lamin structur interfaci failur load n similar ultim load unlamin film n toward engin wood marin biopolym composit array line caalg print wood veneer panel dri bond follow activ calcium yield fulli bond wood two pli lamin system present herein provid blueprint adopt marin alga deriv polysaccharid develop sustain high perform materi | D000077322;D002118 | T121;T109;T123;T196 |
36,215,497 | morpholog similar amygdala ventral prefront pathway repres trait anxieti younger older adult stronger amygdala ventral prefront white matter connect associ lower trait anxieti possibl reflect increas capac effici communic two region howev also report argu brain anxieti associ address inconsist literatur test possibl idiosyncrat tract morpholog may account meaning individu differ trait anxieti even among compar microstructur integr adopt intersubject represent similar analysi analyt framework captur multivari pattern similar analyz morpholog similar amygdala ventral prefront pathway data drawn leipzig studi mind bodi emot interact dataset show younger adult age low trait anxieti contrast trait anxious individu consist similar morpholog configur left amygdala ventral prefront pathway addit test independ sampl older adult age valid find studi reveal generaliz pattern brain anxieti associ embed within share geometri fiber tract morpholog trait anxieti data | D000679;D017397 | T023;T030;T029 |
36,215,496 | connect sequenc featur within disord c termin linker bacillus subtili ftsz function bacteri cell divis intrins disord region idr function autoregul fold enzym tether one exampl bacteri cell divis protein ftsz includ fold core c termin tail ctt encompass poor conserv disord c termin linker ctl well conserv residu c termin peptid ct site gtpase activ ftszs form interfac gtp bind site loop core adjac subunit within dimer explor basi autoregulatori function ctt bacillus subtili ftsz bs ftsz molecular simul show ct bs ftsz make statist signific ctl mediat contact loop statist coupl analysi sequenc ftsz ortholog reveal clear covari loop ct core domain wherea ctl independ select despit discov conserv nonrandom sequenc pattern within ctls across ortholog test nonrandom pattern ctls mediat ctt core interact modul ftsz function design bs ftsz variant alter pattern opposit charg residu within ctl alter disrupt core ctt interact lead anomal assembl ineffici gtp hydrolysi vitro protein degrad aberr assembl disrupt cell divis vivo find suggest viabl ctls ftszs like idr encompass nonrandom function relev sequenc pattern also preserv three way covari ct loop core domain | D001412;D003598 | T007;T123;T116 |
36,215,495 | global airborn bacteri communiti interact earth microbiom anthropogen activ airborn bacteria influenti compon earth microbiom communiti structur biogeograph distribut pattern yet understood analyz bacteri communiti air particul sampl collect site around world construct airborn bacteri refer catalog million nonredund ribosom rna rrna gene sequenc present biogeograph pattern deciph interlac microbiom co occurr network surfac environ earth total abund global airborn bacteria tropospher cell order magnitud lower habitat number bacteri taxa ie rich atmospher compar hydrospher maximum occur midlatitud region also observ ecosystem airborn bacteri communiti harbor uniqu set domin taxa speci howev structur appear easili perturb due promin role stochast process shape communiti assembl corrobor major contribut surfac microbiom airborn bacteria averag atmospher condit meteorolog factor air qualiti also play role particular urban area human impact weaken relat import plant sourc airborn bacteria elev occurr potenti pathogen anthropogen sourc find serv key refer predict planetari microbiom respons health impact inhal microbiom futur chang environ | D000391;D064307 | T001;T067;T032;T028 |
36,215,494 | mechan ion adsorpt aqueous interfac air water vs oil water adsorpt ion water hydrophob interfac influenc wide rang phenomena includ chemic reaction rate ion transport across biolog membran electrochem mani catalyt process henc develop detail understand behavior ion water hydrophob interfac central interest character adsorpt chaotrop thiocyan anion scn two prototyp liquid hydrophob surfac water toluen water decan surfac sensit nonlinear spectroscopi compar result previous studi scn adsorpt air water interfac system observ spectral shift charg transfer solvent spectrum scn gibb free energi adsorpt three differ interfac agre within error employ molecular dynam simul develop molecular level understand adsorpt mechan found adsorpt scn water toluen water decan interfac driven increas entropi littl enthalp contribut qualit differ mechan report scn adsorpt air water graphen water interfac wherein favor enthalpi chang main drive forc unfavor entropi chang | D006108;D014867 | T121;T109;T196;T197 |
36,215,493 | bend curv simpl massiv conserv action lead landscap scale recoveri amphibian success stori rare conserv scienc hinder also research implement gap scientif insight rare inform practic practic implement rare evalu scientif amphibian popul declin driven multipl stressor emblemat freshwat biodivers crisi habitat creation straightforward conserv action shown local benefit amphibian well taxa benefit entir amphibian communiti larg spatial scale evalu landscap scale pond construct program fit dynam occup model monitor data pond breed amphibian speci swiss state aargau dens popul area swiss lowland intens land use decad popul declin number occupi pond increas statewid speci one speci remain stabl one speci declin despit region differ region metapopul colon subsequ occup new pond stabil increas metapopul size like mechan includ increas habitat avail restor habitat dynam increas connect pond colon probabl reflect speci specif prefer characterist pond surround provid evid base inform futur pond construct target specif speci relat simpl landscap scale persist conserv action construct hundr new pond halt declin stabil increas state wide popul size one speci despit ongo pressur stressor human domin landscap | D000663;D044822 | T011;T080 |
36,215,492 | epigenet factor competit reshap emt landscap emerg transit distinct phenotyp isogen cell attribut intric interplay epigenet mark extern signal gene regulatori element element includ chromatin remodel histon modifi transcript factor regulatori rnas mathemat model known gene regulatori network grns increas import tool unravel work complex network model epigenet factor usual propos act chromatin region direct involv express relev gene howev well establish factor oper global compet target genom wide therefor perturb activ regul redistribut epigenet mark across genom modul level compet regul paper propos conceptu mathemat model framework incorpor local global competit effect antagonist epigenet regul addit local transcript factor show counterintuit consequ interact appli approach recent experiment find epitheli mesenchym transit emt show explain puzzl experiment data well provid verifi predict | D058750;D006657 | T043;T123;T116 |
36,215,490 | tetraspanin mediat mhc class cluster requir optim cd cell activ mhc molecul random distribut plasma membran instead present discret nanoclust mechan control format mhc nanoclust import structur incomplet understood report molecular associ tetraspanin tspan mhc molecul start endoplasm reticulum maintain plasma membran associ observ mous dendrit cell human cancer cell line loss tspan reduc size mhc cluster without affect mhc peptid load deliveri complex plasma membran overal surfac mhc level function cd cell respons antigen present tspan defici dendrit cell impair restor antibodi induc reclust mhc molecul contrast tspan associ two plasma membran protein flotillin cd endoplasm reticulum protein tapasin tap thus find identifi mechan under cluster mhc molecul import optim cell respons | D017951;D015395 | T043;T109;T116;T129 |
36,215,489 | deep branch acetogen serpentin subsurfac fluid oman littl known acetogen contemporari serpentin system despit wide support theori serpentinit host environ support first life earth via acetogenesi address knowledg gap genom resolv metagenom appli subsurfac fractur water communiti area activ serpentin samail ophiolit sultan oman two deepli branch putat bacteri acetogen type identifi communiti belong acetothermia hereaft type ii exhibit distinct distribut among water lower higher water rock reaction ie serpentin influenc respect metabol reconstruct reveal contrast core metabol pathway type ii acetothermia includ acetogen pathway compon eg bacteri vs archaeal like carbon monoxid dehydrogenas codh respect hydrogen use drive acetogenesi chemiosmot potenti generat via respiratori type canon acetogen ferredoxin base complex type ii notabl type ii acetothermia metabol pathway allow use serpentin deriv substrat implic key primari produc contemporari hyperalkalin serpentinit environ phylogenom analys indic archaeal like codh type ii genom serpentinit associ bacteria deriv deepli root horizont transfer origin among archaeal methanogen acetothermia among earliest evolv bacteri lineag discoveri domin earli branch acetogen subsurfac water largest near surfac serpentinit format provid insight physiolog trait like facilit rock support life flourish primit earth possibl rocki planet undergo serpentin | D002248;D005288 | T123;T131;T116;T197 |
36,215,488 | languag development plastic perinat stroke matur human brain later languag left hemispher lh primarili respons sentenc process right hemispher rh primarili respons process suprasegment aspect languag vocal emot howev long hypothes earli life plastic languag allow young children acquir languag cortic region lh area damag true constraint function reorgan area brain acquir languag happen function region ordinarili perform address question examin long term outcom adolesc young adult infant perinat arteri ischem stroke lh area ordinarili subserv sentenc process compar healthi age match sibl particip test batteri behavior function imag task stroke particip impair nonlinguist cognit abil process sentenc vocal emot normal equal healthi sibl almost abil develop healthi rh result provid insight remark abil young brain reorgan languag reorgan high constrain sentenc process almost alway rh frontotempor region homotop locat healthi brain activ somewhat segreg rh emot process suggest two function perform best neural territori | D007802;D020521 | T047;T171 |
36,215,487 | origin recognit complex harbor intrins nucleosom remodel activ eukaryot dna replic initi multipl chromosom site known origin replic specif recogn origin recognit complex orc contain multipl atpas site bud yeast orc bind specif dna sequenc known autonom replic sequenc arss most nucleosom deplet howev nucleosom may still inhibit licens origin occlud orc bind subsequ mcm helicas load use purifi protein singl molecul visual find orc eject histon nucleosom atp depend manner orc select evict ha hb dimer leav h h tetram dna also discrimin canon ha haz variant evict former retain latter final bromo adjac homolog bah domain orc subunit essenti orc mediat histon evict find suggest orc bona fide nucleosom remodel function creat local chromatin environ optim origin activ | D009707;D051738 | T123;T116 |
36,215,486 | substitut near ha receptor bind site explain origin major antigen chang bvictoria byamagata lineag influenza b virus primarili infect human caus season epidem global two antigen variant victoria like yamagata like detect molecular basi emerg still incomplet understood antigen properti uniqu collect histor virus isol sampl passag exclus mammalian cell preserv antigen properti determin hemagglutin inhibit assay antigen map built quantifi visual diverg lineag antigen map reveal three distinct antigen cluster earli victoria yamagata relat littl antigen divers cluster virus victoria like antigen properti emerg around diversifi subsequ two genet lineag virus yamagata like antigen properti evolv one lineag becam clear antigen distinct victoria like virus around recombin mutant virus test show insert delet indel observ frequent influenza b virus hemagglutinin littl effect antigen properti contrast amino acid substitut posit adjac hemagglutinin receptor bind site determin main antigen differ earli victoria like yamagata like virus surpris substitut two four posit revert recent virus victoria lineag result antigen properti similar virus circul earlier data shed light antigen diversif influenza virus suggest may limit antigen evolut influenza b virus | D007251 | T047 |
36,215,485 | coevolut tandem repeat hlip rpab like transcript factor confer desicc toler subaeri nostoc speci desert inhabit cyanobacteria toler extrem desicc quick reviv rehydr regulatori mechan enabl veget cell resurrect upon rehydr poor understood studi identifi singl gene famili high light induc protein hlip dramat expans nostoc flagelliform genom found intrigu special converg form four tandem gene duplic emerg four independ hlip gene form gene cluster hlip cluster respond dehydr posit gene mutant n flagelliform success generat use gene edit technolog phenotyp analysi show desicc toler hlip cluster delet mutant decreas signific due impair photosystem ii repair wherea heterolog express hlip cluster n flagelliform enhanc desicc toler nostoc sp pcc furthermor transcript factor hrf hlip cluster repressor factor identifi shown coordin regul express hlip cluster desicc induc psbas hrf act negat regul adapt n flagelliform harsh desert environ phylogenet analysi reveal speci nostoc genus possess tandem repeat hlip hrf result suggest converg evolut desicc toler coevolut tandem hlip duplic hrf subaeri nostoc speci provid insight mechan desicc toler photosynthet organ | D046937;D045332 | T116;T007;T026;T126;T123 |
36,215,484 | digit media drive affect polar partisan sort polit recent decad enter era intens polar explan implic digit media call echo chamber remain domin causal hypothesi despit grow challeng empir evid paper suggest mount evid provid reason reject echo chamber hypothesi also foundat altern causal mechan propos mechan paper draw literatur affect polar digit media opinion dynam affect polar literatur follow move see polar diverg issu posit root sort align differ effect divid elector two increas homogen megaparti explain rise sort paper draw opinion dynam digit media research present model essenti turn echo chamber head isol oppos view drive polar precis fact digit media bring us interact outsid local bubbl individu interact local outcom stabl plural patchwork cross cut conflict encourag nonloc interact digit media drive align conflict along partisan line thus effac counterbalanc effect local heterogen result polar even individu interact lead converg model thus suggest digit media polar partisan sort creat maelstrom ident belief cultur prefer becom drawn encompass societ divis | D020407;D011057 | T068;T073;T090;T055;T170;T057;T078 |
36,215,482 | insect herbivori within modern forest greater fossil local fossil leav provid longest run record hyperdivers plant insect herbivor associ reconstruct relationship deep time indic strong link environment condit herbivor divers feed damag leav howev herbivori compar past modern era character intens anthropogen environment chang present estim damag frequenc divers fossil leav late cretac pleistocen compar estim recent post leav collect via paleobotan method modern ecosystem harvard forest unit state smithsonian environment research center unit state la selva costa rica total damag frequenc measur percentag leav herbivor damag within modern ecosystem greater fossil local within record pattern driven increas frequenc across near function feed group within recent divers total special mine damag type elev within recent compar fossil flora result demonstr plant modern era experienc unpreced level insect damag despit widespread insect declin human influenc rate global climat warm influenc insect feed time life cycl process along urban introduct invas plant insect speci may drive elev herbivori research suggest strength human influenc plant insect interact control climat chang alon rather way human interact terrestri landscap | D005580;D060434 | T008;T167;T040 |
36,215,480 | full activ mechan adenosin receptor reveal gamd su gamd simul full activ process g protein coupl receptor gpcr play import role cellular signal transduct howev remain challeng simul whole process gpcr recogn activ ligand coupl g protein reason simul timescal develop molecular dynam md approach name supervis su gaussian acceler md gamd incorpor tabu like supervis algorithm standard gamd simul use su gamd method activ inact structur adenosin receptor r success reveal full activ mechan r includ adenosin ado r recognit preactiv r r g protein recognit hundr nanosecond simul bind ado extracellular side r initi conform chang preactiv r turn bind g intracellular side r caus decreas volum extracellular orthoster site stabil bind ado r su gamd could use tool reconstruct even predict ligand protein protein protein recognit pathway short timescal intermedi state reveal studi could provid detail complementari structur character facilit drug design r futur | D056004;D018047 | T044;T066;T116;T192 |
36,215,479 | bip yorki interact determin oncogen tumor suppress role irexbp activ unfold protein respons upr mechan cell control endoplasm reticulum er protein homeostasi er proteostasi essenti adapt cell prolifer regener develop tumorigenesi mechan link upr growth control cancer progress remain unclear report irexbp pathway surpris oncogen tumor suppress role context depend manner activ irexbp regul downstream target bip sequest yorki yki hippo pathway transduc cytoplasm restrict yki transcript output regul provid endogen defens mechan organ size control intestin homeostasi regener unexpect xbp ablat promot tumor overgrowth suppress invas drosophila cancer model mechanist hyperactiv irexbp signal turn induc jnk depend development oncogen cell migrat epitheli mesenchym transit emt via repress yki human negat correl xbp yap yki ortholog target gene express specif exist tripl negat breast cancer tnbcs high xbp hspa bip ortholog express better clinic outcom human tnbc cell line xenograft model ectop xbps hspa express allevi tumor growth aggrav cell migrat invas find uncov conserv crosstalk irexbp hippo signal pathway physiolog set well crucial role bip yki interact tumorigenesi share drosophila human | D029721;D017346 | T126;T123;T116 |
36,215,477 | lyl facilit aetfc assembl gene activ recruit carm aml transcript factor tfs play critic role hematopoiesi aberr express lead various type leukemia leukemogen fusion protein aml eto ae common fusion protein acut myeloid leukemia enhanc hematopoiet stem cell renew block differenti key question understand ae mediat leukemia determin choic ae activ self renew gene repress differenti gene toward resolut problem earlier show ae resid stabl aetfc complex compon coloc regul target gene essenti leukemogenesi current studi use biochem genom approach show ae contain complex heterogen assembl larger aetfc contain ae cbf heb ea lyl lmo ldb requir lyl furthermor provid strong evid lyl contain aetfc preferenti bind activ enhanc promot ae depend gene activ moreov show coactiv carm interact aetfc facilit gene activ aetfc collect studi describ role oncoprotein lyl aetfc assembl gene activ recruit carm chromatin aml cell surviv | D015470;D015514 | T191;T116 |
36,215,474 | factor influenc terrestri primat america madagascar among mammal order primat except high taxonom rich taxa arbor semiterrestri terrestri although habitu terrestri pervas among ape african asian monkey catarrhin larg absent among monkey america platyrrhin well galago lemur loris strepsirrhin most arbor numer ecolog driver speci specif factor suggest set condit evolutionari shift arbor terrestri current environment condit may provid analog scenario transit period therefor investig predomin arbor diurnal primat genera america madagascar lack fulli terrestri taxa determin whether ecolog driver habitat canopi cover predat risk maximum temperatur precipit primat speci rich human popul densiti distanc road speci specif trait bodi mass group size degre frugivori associ increas terrestri collat observ hour across month speci site madagascar site america multipl factor associ ground use otherwis arbor speci includ increas temperatur decreas canopi cover dietari shift away frugivori larger group size factor most explain intraspecif differ terrestri human modifi habitat caus climat chang result suggest speci alreadi inhabit hot spars canopi site exhibit general diet like shift toward greater ground use | D005075;D011323 | T015;T045 |
36,215,473 | attenu relaps fever neuroborreliosi mice il blockad relaps fever due borrelia hermsii character recurr bacteremia episod howev infect b hermsii treat earli spread various organ includ central nervous system cns cns diseas manifest common refer relaps fever neuroborreliosi rfnb mous model b hermsii infect previous shown develop rfnb requir innat immun cell well cell found prior onset rfnb increas system proinflammatori cytokin respons follow sustain level ip concurr cns diseas phase rna sequenc analysi spinal cord tissu diseas phase reveal associ interleukin il signal pathway rfnb test possibl role il rfnb compar b hermsii infect wild type il mice although onset bacteremia protect anti b hermsii antibodi respons occur similar blood brain barrier permeabl proinflammatori cytokin level immun cell infiltr spinal cord rfnb manifest signific diminish il mice compar wild type mice treatment b hermsii infect wild type mice anti il antibodi amelior sever spinal cord inflamm microgli cell activ rfnb data suggest il signal pathway play major role pathogenesi rfnb il blockad may therapeut modal control neuroborreliosi | D016470;D012061 | T047 |
36,215,472 | spatial pattern climat chang across paleocen eocen thermal maximum paleocen eocen thermal maximum petm one best geolog analog understand climat dynam greenhous world howev proxi data repres event avail select marin terrestri sedimentari sequenc uneven distribut across earth surfac limit view spatial pattern climat chang use paleoclim data assimil da combin climat model proxi inform creat spatial complet reconstruct petm climat state preced petm da data constrain result support strong polar amplif absenc extens cryospher relat temperatur feedback loss season snow land respons hydrolog cycl petm warm consist narrow intertrop converg zone equatori dri intensif season monsoon winter storm track mani featur also seen simul futur climat chang increas anthropogen emiss sinc petm da yield spatial complet estim surfac air temperatur yield rigor estim global mean temperatur chang c c c ci use calcul equilibrium climat sensit ec find petm ec c c c ci much higher present day rang support view climat sensit increas substanti greenhous gas concentr high | D057231;D000074382 | T197;T070 |
36,215,471 | unstructur linker mlh contain motif requir endonucleas function mutat cancer eukaryot dna mismatch repair mmr depend recruit mlh pms endonucleas human mlh pms mispair dna mlh pms contain long unstructur linker connect n carboxyl termin domain demonstr mlh linker contain conserv motif saccharomyc cerevisia residu requir mmr mlh ra da pms linker motif mutant protein defect mmr endonucleas activ vitro even though conserv motif could carboxyl termin endonucleas activ site n termin adenosin triphosph atp bind site peptid encod motif inhibit wild type mlh pms endonucleas activ motif function vivo differ site within mlh linker within pms linker motif mutat human cancer caus loss function phenotyp model cerevisia result suggest mlh motif promot pcna activ endonucleas activ mlh pms via interact dna pcna rfc domain mlh pms complex | D009369;D029701 | T191;T116 |
36,215,470 | import intern climat variabl climat impact project uncertainti climat project driven three compon scenario uncertainti intermodel uncertainti intern variabl although socioeconom climat impact studi increas take account first two compon littl attent paid role intern variabl although underestim uncertainti may lead underestim socioeconom cost climat chang use larg ensembl seven coupl general circul model total model run partit climat uncertainti classic dose respons model relat counti level corn yield mortal per capita gross domest product temperatur continent unit state partit uncertainti depend time frame project impact model geograph region intern variabl repres total climat uncertainti certain project includ mortal project earli st centuri although relat influenc decreas time recommend includ uncertainti due intern variabl mani project temperatur driven impact includ earli centuri midcenturi project project region high intern variabl upper midwest unit state impact driven nonlinear relationship | D057231;D003313 | T168;T002;T070 |
36,215,469 | seismic detect deep mantl discontinu within mar insight constrain thermal composit state mantl crucial deciph format evolut mar miner physic predict mar deep mantl demarc seismic discontinu aris pressur induc phase transform miner olivin higher pressur polymorph make depth boundari sensit mantl temperatur composit report seismic detect midmantl discontinu use data collect nasa insight mission mar match expect depth sharp postolivin transit five teleseism event observ triplic p wave constrain depth discontinu formula see text km model triplic waveform depth rang infer mantl potenti temperatur formula see text k result consist crust time enrich heat produc element under mantl waveform fit data indic broad gradient across boundari impli martian mantl enrich iron compar earth model thermochem evolut mar observ two five propos composit model compat observ boundari depth geodynam simul suggest martian mantl relat cold gyr ago k consist present day surfac heat flow mwm | D005118;D018535 | T083;T070 |
36,215,468 | direct observ step rotat v atpas reveal rigid compon coupl v v motor v atpas rotari motor protein convert chemic energi atp electrochem potenti ion across cell membran v atpas consist two rotari motor v v enterococcus hira v atpas ehv v activ transport na v ehv use torqu generat atp hydrolysi v ehv observ atp driven step rotat deterg solubil ehv v wild type aea brk mutant various na atp concentr na atp respect use nm gold nanoparticl low load probe na low atp high condit na bind ehv rate limit wild type aea exhibit paus posit reflect fold symmetri ehv rotor almost backward step durat time forward step invers proport na confirm na bind trigger step atp na low condit na atp bind rate limit aea exhibit paus posit reflect fold symmetri ehv ehv respect distribut durat time forward step fit well sum two exponenti decay function distinct time constant furthermor occasion backward step smaller observ small backward step also observ three long atp cleavag paus brk result indic ehv ehv share paus posit na atp bind occur differ angl coupl ehv ehv rigid compon | D053768;D025262 | T116;T126;T073 |
36,215,467 | acoust forc spectroscopi reveal subtl differ cellulos unbind behavior carbohydr bind modul protein adsorpt solid carbohydr interfac critic mani biolog process particular biomass deconstruct engin effici enzym biomass deconstruct sugar necessari character complex protein carbohydr interfaci interact carbohydr bind modul cbm often associ microbi surfac tether cellulosom secret cellulas enzym enhanc substrat access howev well known cbms recogn bind dissoci polysaccharid facilit effici cellulolyt activ due lack mechanist understand suitabl toolkit studi cbm substrat interact work outlin general approach studi unbind behavior cbms polysaccharid surfac use high multiplex singl molecul forc spectroscopi assay appli acoust forc spectroscopi af probe clostridium thermocellum cellulosom scaffoldin protein cbma measur dissoci nanocellulos surfac physiolog relev low forc load rate autom microfluid setup method uniform deposit insolubl polysaccharid af chip surfac demonstr ruptur forc wild type cbma ya mutant unbind nanocellulos surfac suggest distinct multimod cbm bind conform structur mechan explor use molecular dynam simul appli classic dynam forc spectroscopi theori singl molecul unbind rate zero forc extrapol found agre bulk equilibrium unbind rate estim independ use quartz crystal microbal dissip monitor howev result also highlight critic limit appli classic theori explain high multival bind interact cellulos cbm bond ruptur forc exceed pn | D002480;D048013 | T121;T007;T126;T116 |
36,215,466 | activ entangl enabl stochast topolog grasp grasp biolog engin mechan high sensit gripper object morpholog well percept motion plan circumv need feedback precis plan use array fluidic actuat slender hollow elastomer filament activ entangl object vari geometr topolog complex result stochast interact enabl uniqu soft conform grasp strategi across rang target object vari size weight shape experiment evalu grasp perform strategi use comput framework collect mechan flexibl filament contact complex object explain find overal studi highlight activ collect entangl filament array via uncontrol spatial distribut scheme provid option soft adapt grasp | D012371 | T090 |
36,215,465 | proxim proteom synaptopodin provid insight molecular composit spine apparatus dendrit spine spine apparatus special compart neuron smooth endoplasm reticulum er locat subset dendrit spine consist stack er cistern interconnect unknown dens matrix continu er dendrit shaft organell first observ ago molecular organ remain mysteri perform vivo proxim proteom gain insight molecular compon use known spine apparatus specif protein synaptopodin target biotinyl enzym organell valid specif local dendrit spine small subset protein identifi approach show coloc synaptopodin express nonneuron cell one protein pdlim actin bind protein previous identifi spine pdlim found interact synaptopodin multipl domain also coloc synaptopodin cistern organell peculiar stack er cistern resembl spine apparatus found axon initi segment subset neuron moreov pdlim express pattern similar synaptopodin brain highlight function partnership two protein compon spine apparatus identifi work help elucid mechan biogenesi mainten enigmat structur implic function dendrit spine physiolog diseas | D049229;D040901 | T026;T091 |
36,215,464 | microbiom composit modul secondari metabol multispeci bacteri communiti bacteri secondari metabolit major sourc antibiot bioactiv compound microbi communiti molecul mediat interspeci interact respons environment chang despit import secondari metabolit human health microbi ecolog littl known role regul context multispeci communiti simplifi model rhizospher compos bacillus cereus flavobacterium johnsonia pseudomona koreensi show dynam secondari metabol depend communiti speci composit interspeci interact compar metatranscriptom metametabolom reveal abund transcript biosynthet gene cluster bgcs metabolom molecular featur differ monocultur dual cultur tripartit communiti two three member cocultur p koreensi modifi express bgcs zwittermicin petrobactin secondari metabolit b cereus f johnsonia wherea bgc transcript respons communiti p koreensi minim pairwis tripartit cocultur p koreensi display uniqu molecular featur appear deriv lokisin suggest metabol handoff speci delet bgc koreencein anoth p koreensi metabolit alter transcript metabolit profil across communiti includ substanti regul petrobactin bacillibactin bgcs b cereus suggest koreencein repress siderophor product result model communiti show bacteri bgc express chemic output depend ident biosynthet capac cocultur partner suggest communiti composit microbiom interact may shape regul secondari metabol natur | D064307;D017262 | T028;T001;T109;T123;T032 |
36,215,463 | antenna reaction center pathway ultrafast energi charg transfer photosystem ii photosystem ii core complex psii cc smallest subunit oxygen photosynthet apparatus contain core antenna reaction center togeth allow rapid energi transfer charg separ ultim lead effici solar energi convers howev lack consensus interplay energi transfer charg separ dynam core complex report applic two dimension electron vibrat dev spectroscopi spinach psii cc k simultan tempor spectral resolut afford dev spectroscopi facilit separ direct assign coexist dynam process result show domin dynam psii cc distinct differ excit energi region separ excit region abl distinguish intraprotein dynam interprotein energi transfer addit improv resolut abl identifi key pigment involv pathway allow direct connect dynam structur inform specif show c cp peripher chlorophyl chlz reaction center like respons energi transfer cp reaction center | D002734;D045332 | T116;T026;T109;T126;T123 |
36,215,462 | structur basi host recognit superinfect exclus bacteriophag key poor understood stage bacteriophag life cycl bind phage receptor bind protein rbps receptor host cell surfac lead inject phage genom lytic phage host cell lysi prevent secondari infect close relat phage nonproduct phage adsorpt lyse cell fragment superinfect exclus se protein prevent bind rbps via modul host receptor structur way also unclear present cryogen electron microscopi cryo em structur phage outer membran om receptor fhua complex rbp pb crystal structur fhua complex om se lipoprotein llp pb insert four loop deepli extracellular lumen fhua contact plug caus conform chang receptor support view dna transloc occur lumen om channel fhua llp structur reveal llp periplasm bind nonnat conform plug fhua caus inward fold two extracellular loop via revers allosteri inward fold loop fhua overlap pb bind site explain llp bind fhua abolish infect escherichia coli phage suggest mechan se via jam tonb depend transport small phage lipoprotein | D001435;D029968;D015163 | T116;T047;T005 |
36,215,461 | age associ maladapt episod memori guid social decis make older adult frequent target victim financi fraud may especi suscept revictim age relat chang episod memori social motiv examin factor context adapt social decis make requir intact associ memori previous social interact older adult made maladapt episod memori guid social decis poorer associ memori older adult bias toward rememb peopl fair young adult bias toward rememb peopl unfair hold memori constant older adult engag peopl familiar regardless natur previous interact wherea young adult prone avoid other rememb unfair final older adult influenc facial appear choos interact social partner look generous even though percept inconsist prior experi | D003657;D061212;D012919 | T054;T041 |
36,215,460 | sweet transport sucros gibberellin restor male fertil arabidopsi sweet sweet sucros transport play import role alloc sucros plant sweet shown also mediat transport plant growth regul gibberellin ga close physiolog relationship sucros ga rais question whether function connect whether one substrat physiolog relev dissect two activ molecular dynam use map bind site sucros ga pore sweet predict bind interact might select sucros ga transport assay confirm predict transport assay nq mutant x higher relat ga activ sn mutant transport sucros impair pollen viabil germin sweet doubl mutant complement sucros select sweet sn sweet nq mutant indic sucros physiolog relev substrat ga transport capac dispens context male fertil therefor ga supplement counter male steril may act indirect via stimul sucros suppli male steril mutant find also relev context role sweet pathogen suscept | D017360;D029681 | T116;T002 |
36,215,455 | method virtual optic section tomographi util shallow depth field method propos high resolut three dimension reconstruct intern structur object planar transmiss imag describ approach use form radiat matter wave principl provid depth field smaller thick sampl physic optic basi method elucid reconstruct algorithm present detail simul exampl demonstr applic method three dimension electron transmiss imag nanoparticl realist radiat dose spatial resolut constraint envisag method applic high resolut transmiss electron microscopi soft x ray microscopi ultrasound imag area | D021621;D014054 | T062;T073;T060 |
36,215,453 | influenc shape size gloss perceiv color differ print object order studi influenc mechan color differ use shape object pair sampl surround five cie color center gray red yellow green blue variat gloss size shape prepar sailner color printer color differ assess observ use gray scale method new color differ data use investig parametr effect gloss shape size perceiv color differ result indic object high gloss small size object cm rais smaller visual color differ matt larg size object cm visual color differ sphere larger cone cylind sampl pair chromat ellips indic glossi sampl differ shape arous fair differ visual percept especi sphere cylind sampl | D005556 | T041 |
36,215,450 | effici multiplex illumin imag approach fourier ptychograph microscopi fourier ptychograph microscop fpm obtain imag high resolut wide field view fov howev time consum process imag acquisit comput lead low reconstruct effici therefor propos state multiplex method optim illumin pattern acceler fpm first reduc redund spectrum analyz impact miss certain sub spectrum overal spectrum reconstruct use imag qualiti evalu method obtain differenti express miss certain led light led light second use differ express select import led obtain optim illumin pattern light led central area edg led updat multiplex method new best knowledg illumin pattern obtain satisfactorili reconstruct imag final valid effect effici method simul experi compar tradit method method acceler reconstruct speed fpm ensur larg fov high resolut save time | D008029;D008853 | T059;T068 |
36,215,446 | biomimet navig system use polar sensor binocular camera vigor develop vision techniqu simultan local map slam shown capabl navig autonom robot global navig satellit system deni environ howev long term robust navig lightweight autonom robot outdoor environ complex interfer illumin chang dynam object electromagnet interfer still great challeng paper polar sensor aid slam pol slam provid absolut head constraint pure slam propos pol slam lightweight tight coupl system consist polar sensor binocular camera mean initi use polar sensor absolut head angl entir map design addit algorithm elimin mismatch point use match point vector propos object function bundl adjust deduc accord project error polar sensor vehicl test show yaw trajectori accuraci pol slam signific improv compar pure slam yaw trajectori accuraci increas respect result indic propos pol slam improv reliabl robust pure slam use lightweight autonom robot outdoor environ | D012371 | T090 |
36,215,445 | estim optic paramet biolog tissu photon count micro ct wavelength depend absorpt scatter properti determin fluoresc photon transport biolog tissu imag resolut optic molecular tomographi current paramet comput optic measur data small anim imag estim optic paramet larg scale optim problem high ill pose paper propos new best knowledg approach estim optic paramet biolog tissu photon count micro comput tomographi micro ct photon count x ray data multi energi micro ct imag reconstruct perform multi organ segment materi decomposit term tissu constitu concentr characterist major tissu constitu util calcul optic absorpt scatter coeffici involv tissu studi perform numer simul phantom experi vivo anim studi calcul optic paramet use propos approach result show approach estim optic paramet tissu relat error accur map optic paramet distribut small anim | D017785;D041622 | T167;T060 |
36,215,444 | accur fast reconstruct bioluminesc tomographi base adapt newton hard threshold pursuit algorithm promis noninvas medic imag techniqu bioluminesc tomographi blt dynam offer three dimension visual tumor distribut live anim howev due high ill posed caus strong scatter properti biolog tissu limit boundari measur nois blt reconstruct still meet actual preliminari clinic applic requir research recov tumor distribut quick precis adapt newton hard threshold pursuit anhtp algorithm propos improv perform blt anhtp algorithm fulli combin advantag sparsiti constrain optim convex optim guarante global converg precis adapt sparsiti adjust strategi develop obtain support set invers system matrix base strong wolf line search criterion modifi damp newton algorithm construct obtain optim sourc distribut inform seri numer simul phantom vivo experi show anhtp high reconstruct accuraci fast reconstruct speed good robust propos algorithm increas practic blt biomed applic | D008163;D014054 | T059;T060 |
36,215,438 | josa emerg research best paper prize editori josa editor chief olga korotkova featur editor johann courtial member emerg research best paper prize committe announc recipi prize best paper publish emerg research journal | D001363 | T073 |
36,215,433 | dimethyl sulfoxid assist iodin ascorb acid catalyz one pot synthet approach construct high substitut pyrazolo quinolin thioether deriv dimethyl sulfoxid assist iodineascorb acid catalyz simpl approach pyrazolo quinolin thioether deriv describ compound identifi use h nmr c nmr high resolut mass spectrometri singl crystal x ray diffractometri pyrazolo quinolin thioether synthes stepwis fashion aryl sulfenyl benzannul strategi generat heteroaryl thioether compound expos benzannul path produc pyrazolo quinolin thioether benzannul reaction proceed way diazot pyrazol amin deriv radic generat remov nitrogen eventu trap aryl radic support phenylacetylen catalyt amount ascorb acid aid benzannul reaction sever control studi conduct includ trap reaction isopropenyl acet tetramethylpiperidin n oxyl reaction reaction without phenylacetylen sinc chang substitut previous demonstr substanti bioactiv core structur pyrazol evalu function group toler reason mechan propos accompani support control experi scope suzuki reaction use creat arylheteroaryl compound one synthes compound b control oxid reaction path molecul select transform correspond sulfoxid sulfon | D007455;D011804;D000981 | T121;T109;T123;T196 |
36,215,429 | pwrbridg user friend web applic power sampl size estim batch confound microarray studi depend sampl b atch effect r educt croarray data epend sampl usin g e mpiric bay bridg recent develop statist method address issu batch effect correct batch confound microarray studi depend sampl key compon bridg methodolog use sampl run technic replic two batch bridg sampl inform batch effect correctionattenu previous publish result indic relationship number bridg sampl statist power downstream statist test batch correct data yet formal statist framework user friend softwar estim achiev specif statist power hypothesi test conduct batch correct data fill gap develop pwrbridg simul base approach estim bridg sampl size batch confound longitudin microarray studi illustr use pwrbridg consid hypothet longitudin batch confound studi whose goal identifi alzheim diseas ad progress associ gene amnest mild cognit impair amci ad human blood year follow pwrbridg help research design plan batch confound microarray studi depend sampl avoid power studi | D012984 | T090;T170;T073 |
36,215,416 | solvent control regioselect reaction methyleneaziridin acrylicpropargyl acid synthesi carboxyl aziridineaceton ester herein report conveni solvent control regioselect esterif access two type carboxyl ester without addit non green activ strategi transform methyleneaziridin serv ester reagent provid two altern electrophil carbon center notabl protocol suitabl structur complic clinic molecul carboxyl acid group present remark applic potenti | D004952;D001388 | T109 |
36,215,413 | photon upconvers low threshold excit intens plain water triplet triplet annihil base photon upconvers tta uc system low threshold excit intens th plain water develop water solubl anion porphyrin pdtpps diphenylanthracen dcdpa deriv use light absorb emitt molecul respect addit surfact requir phosphoresc emiss pdtpps excit wavelength nm quench dcdpa result triplet energi transfer wherea fluoresc dcdpa observ short wavelength region nm three independ emiss studi util differ excit light sourc valid tta uc process simpl aqueous solut tta occur triplet energi transfer accord time profil phosphoresc fluoresc detect follow puls laser excit th tta uc estim lower mw cm although could exact determin due sensit limit experiment setup upper limit th aqueous solut dcdpa pdtpps smallest valu obtain date aqueous system compar high perform tta uc system organ solut | D014867;D011166 | T121;T109;T123;T197 |
36,215,403 | ultrahigh mechan strength robust room temperatur self heal properti polyurethan graphen oxid network result multipl dynam bond address conflict achiev high mechan properti room temperatur self heal abil extrem signific achiev breakthrough applic self heal materi therefor inspir natur spider silk nacr room temperatur self heal supramolecular materi ultrahigh strength tough develop synergist incorpor flexibl disulfid bond dynam sextupl hydrogen bond h bond polyurethan pus simultan abund h bond introduc interfac graphen oxid nanosheet dynam multipl h bond pu matrix afford strong interfaci interact result urea contain pu materi invers artifici nacr structur record mechan strength mpa tough mj superior tensil properti elong break rapid room temperatur self heal abil c h form strongest room temperatur self heal elastom report date thus upend previous understand tradit self heal materi addit bionic pu graphen oxid network endow fabric flexibl intellig robot function repair shape memori capabl thus provid prospect fabric flexibl function devic | D060734 | T109 |
36,215,398 | impact fdg petct scan chang manag well differenti neuroendocrin tumor ki index less equal studi aim see impact fdg petct somatostatin receptor pet sstr pet direct treatment plan lower grade well differenti neuroendocrin tumor net ki index | D018358;D009942 | T191;T109 |
36,215,397 | ga fapi versus f fdg petct detect epithelioid malign pleural mesothelioma describ ga fapi fibroblast activ protein inhibitor f fdg petct find case epithelioid malign pleural mesothelioma compar f fdg petct ga fapi petct clear show pleural tumor lymph node metastas detect pleural lesion tumor show higher ga fapi activ case indic ga fapi petct may promis new tool evalu malign pleural mesothelioma need investig | D000086002;D010997 | T191 |
36,215,396 | predict treatment respons primari aldosteron use c metomid positron emiss tomographi appropri treatment primari aldosteron pa depend accur later c metomid mto tracer use pet provid function inform adren cortex aim perform mto pet patient pa manag accord guidelin verifi correl later modal use outcom predict | D000301;D006929 | T047;T109;T130 |
36,215,395 | correl global region amyloid burden f florbetaben petct cognit impair profil sever assess correl profil sever deterior neuropsycholog assess affect region amyloid pet semiquantif influenc vascular risk potenti confound factor also evalu | D000544;D000686;D060825;D003704 | T047;T048 |
36,215,391 | femor stem cement primari total hip arthroplasti femor stem cement undergon consider investig sinc bone cement first use arthroplasti lead evolut modern femor stem cement techniqu | D019644;D000072161 | T061;T097 |
36,215,361 | unsupervis outlier detect use memori contrast learn outlier detect separ anomal data inlier dataset recent deep learn method outlier detect leverag auxiliari reconstruct task assum outlier difficult recov normal sampl inlier howev alway true deep auto encod ae base model auto encod base detector may recov certain outlier even outlier train data constrain featur learn instead think outlier detect done featur space measur distanc outlier featur consist featur inlier achiev propos unsupervis outlier detect method use memori modul contrast learn modul mcod memori modul constrain consist featur mere repres normal data contrast learn modul learn discrimin featur boost distinct outlier inlier extens experi four benchmark dataset show propos mcod perform well outperform eleven state art method | D000465 | T170 |
36,215,357 | associ latent represent cognit map via hyperspher space neural popul spike recent focus draw progress represent learn obtain identifi interpret latent represent spike train help analyz neural popul activ understand neural mechan exist deep generat model adopt care design constraint captur meaning latent represent neural data involv navig cognit space base insight studi cognit map argu good represent reflect direct natur due manifold mismatch model util euclidean space learn distort geometr structur difficult interpret present work explor captur direct natur simpler yet effici way introduc hyperspher neural latent variabl model snlvm snlvm improv deep latent variabl model model neural activ behavior variabl simultan hyperspher latent space bridg cognit map latent variabl model conduct experi model static unidirect task result show snlvm competit perform hyperspher prior natur provid inform signific better latent structur interpret spatial cognit map | D007858;D008962 | T061;T041;T170;T062 |
36,215,336 | karyotyp variat spontan genom rearrang affect chemic insensit express level polymorph plant pathogen phytophthora infestan reveal use first chromosom scale assembl natur isol potato tomato pathogen phytophthora infestan exhibit substanti variat virul chemic sensit ploidi trait chromosom scale assembl develop expand genom resourc oomycet microb use explor basi variat use pacbio illumina data long rang link librari optic map assembl creat coalesc pseudochromosom span mb use snp base genet linkag data de novo gene predict combin transcript evid identifi protein code gene plus eight thousand trna gene chromosom compris mosaic gene rich gene spars region plus long centromer gene exhibit bias distribut across chromosom especi member famili encod rxlr crn effector cluster certain chromosom strike half f progeni diploid parent polyploid aneuploid substanti express level polymorph strain identifi much could attribut differ chromosom dosag transpos element insert adjac repetit dna qtl analysi identifi locus right arm chromosom govern sensit crop protect chemic metalaxyl strain heterozyg resist often experienc megabas size delet part chromosom cultur metalaxyl increas resist due loss sensit allel studi shed light divers phenomena affect variat p infestan relat help explain preval polyploidi natur popul provid new foundat biolog genet investig | D055750;D011198;D001688 | T002;T121;T123;T168;T204 |
36,215,335 | character multipurpos ns surfac patch coordin hcv replicas assembl virion morphogenesi hepat c virus hcv life cycl high regul character step wise success interact viral host cell protein result assembl macromolecular complex catalys genom replic andor virus product non structur ns protein compris proteas helicas domain involv orchestr process undergo protein interact tempor fashion recent identifi multifunct ns proteas surfac patch promot pivot protein protein interact requir earli step hcv life cycl includ ns mediat ns proteas activ interact requir replicas assembl work extend knowledg identifi ns surfac determin import nsa hyperphosphoryl replicas assembl virion morphogenesi map proteas helicas domain form contigu ns surfac area function interrog led identif phylogenet conserv amino acid posit exert critic function virion product without affect rna replic find illustr ns use multipurpos protein surfac orchestr step wise assembl function distinct multiprotein complex taken togeth data provid basi dissect tempor format viral multiprotein complex requir individu step hcv life cycl | D016174;D006526 | T047;T005 |
36,215,334 | potenti driver schistosomiasi persist popul genet analys cluster random urogenit schistosomiasi elimin trial across zanzibar island world health organ revis ntd roadmap newli launch guidelin target elimin schistosomiasi public health problem endem area key meet goal elucid select pressur impos intervent shape parasit popul aim identifi differenti impact uniqu cluster random tri arm elimin intervent biannual mass drug administr mda appli alon associ either molluscicid snail control behaviour chang intervent across two zanzibarian island pemba unguja popul genet composit schistosoma haematobium space time fifteen microsatellit loci use analys individu miracidia collect infect individu across island intervent arm start baselin miracidia children adult age rang mean year year miracidia children adult age rang mean year measur genet divers includ allel rich ar expect observ heterozygos ho inbreed coeffici fst parentag analysi estim worm burden worm fecund genet sub structur littl evid differenti select pressur popul genet divers inbreed estim worm burden treatment arm mdasnail control arm within unguja show trend toward reduc divers alter inbreed time greatest differ overal term parasit fecund genet sub structur observ island consist pemba persist higher mean infect intens compar neighbour unguja within island term infect hotspot across three definit find highlight import contribut popul genet analys elucid extens genet divers biolog driver includ potenti gene environment factor may overrid short term select pressur impos differenti diseas control strategi trial registr clinicaltrialsgov isrctn | D000871;D012553 | T121;T047 |
36,215,333 | experiment guidanc discov genet network hypothesi reduct time seri larg program dynam gene express like cell cyle circadian rhythm control relat small core network transcript factor post translat modifi work concert mutual regul recent work suggest system independ quantit featur dynam gene express use identifi core regul introduc approach iter network hypothesi reduct time seri data increas complex featur dynam express individu pair entir collect gene use infer function network model produc observ transcript program culmin work comput pipelin iter network hypothesi reduct tempor dynam inher dynam pipelin provid prioriti list target genet perturb experiment infer network structur demonstr capabl integr comput pipelin synthet yeast cell cycl data | D053263;D014157 | T044;T123;T116 |
36,215,332 | notabl global heterogen distribut covid case associ pre exist parasit diseas coronavirus diseas covid respiratori diseas caus extens ravag worldwid sinc declar pandem world health organ unlik initi predict incid sever covid appear milder mani low middl incom countri lmic explain notic dispar countri mani hypothes includ socio demograph geograph factor put forward studi aim estim possibl associ parasit diseas covid either protect agent potenti risk factor | D000086382 | T047;T067 |
36,215,331 | inhibit vaccinia virus l n myristoyl host n myristoyltransferas inhibitor imp generat non infecti virion defect cell entri recent shown replic rhinovirus poliovirus foot mouth diseas virus requir co translat n myristoyl viral protein human host cell n myristoyltransferas nmts inhibit treatment imp ultrapot small molecul nmt inhibitor examin import n myristoyl vaccinia virus vacv infect primat cell demonstr anti poxvir effect imp n myristoyl protein vacv host metabol label myrist acid alkyn infect use quantit chemic proteom identifi vacv protein g l n myristoyl treatment nmt inhibitor imp potent abrog vacv infect vacv gene express dna replic morphogenesi ev format remain unaffect import observ loss n myristoyl result great reduc infect assembl matur virus particl character signific reduc host cell entri declin membran fusion activ progeni virus n myristoyl vacv entri protein l g inhibit imp mutat genet studi demonstr n myristoyl l critic vacv entri given signific genet ident vacv monkeypox virus variola virus l homolog data provid basi investig role n myristoyl poxvir infect well potenti select nmt inhibitor like imp broad spectrum poxvirus inhibitor | D014616;D014615 | T047;T005 |
36,215,330 | clinic hematolog profil children dengu resid non endem zone bangladesh clinic hematolog paramet children dengu outbreak non endem region well describ delin clinic profil pediatr case tertiari care center locat non endem zone tangail district bangladesh object studi | D019595;D005076 | T047;T184 |
36,215,327 | effect app base home exercis program self report pain intens unspecif degen back pain pragmat open label random control trial recommend first line treatment unspecif degen back pain consist movement exercis patient educ | D063731 | T170 |
36,215,326 | obsess compuls disord character decreas pavlovian influenc instrument behavior obsess compuls disord ocd character uncontrol repetit action thought reli abnorm within fundament instrument learn system investig cognit comput mechan under pavlovian bias instrument behavior clinic ocd patient healthi control use pavlovian instrument transfer pit task pit typic evidenc increas respond presenc posit previous reward pavlovian cue reduc respond presenc negat cue thirti ocd patient thirti one healthi control complet pavlovian instrument transfer test includ instrument train pavlovian train posit negat neutral cue pit phase particip perform instrument task presenc pavlovian cue modifi rescorla wagner model fit trial trial data particip estim under comput mechan quantifi individu differ train transfer stage bayesian hierarch method use estim free paramet compar model behavior comput result indic weaker pavlovian influenc instrument behavior ocd patient hc especi negat pavlovian cue result contrast increas pit effect report anoth set disord character compuls substanc use disord pit enhanc possibl reason reduc pit ocd may impair use contextu inform provid cue appropri adjust behavior especi inhibit respond negat cue present studi provid deeper insight understand deficit ocd perspect pavlovian influenc instrument behavior may implic ocd treatment modal focus reduc compuls behavior | D003216;D009771 | T041;T048 |
36,215,325 | rapid detect recognit whole brain activ freeli behav caenorhabd elegan advanc volumetr imag method genet encod activ indic permit comprehens character whole brain activ singl neuron resolut caenorhabd elegan constant motion deform nematod nervous system howev impos great challeng consist identif dens pack neuron behav anim propos cascad solut long term rapid recognit head ganglion neuron freeli move c elegan first potenti neuron region stack fluoresc imag detect deep learn algorithm second dimension neuron region fuse dimension neuron entiti third exploit neuron densiti distribut surround neuron relat posit inform neuron multi class artifici neural network transform engin neuron featur vector digit neuron ident small number train sampl bottom approach abl process volum voxel less second achiev accuraci neuron detect neuron track long video record work repres step toward rapid fulli autom algorithm decod whole brain activ under naturalist behavior | D017173;D001921 | T023;T204 |
36,215,324 | probabilist edg weight fine tune boolean network dynam biolog system noisi natur aspect reflect experiment measur reflect model build better understand system nois especi consequenti tri interpret specif regulatori interact ie regulatori network edg paper propos method explicit encod edg nois boolean dynam system probabilist edg weight pew oper pew oper two import featur first introduc form edg weight boolean model nois second nois depend dynam state system enabl biolog meaning model choic moreov offer simpl use implement alreadi well establish booleannet framework two applic case show introduct pew oper boolean model fine tune emerg dynam increas accuraci qualit predict includ fine tune interact caus non biolog behavior switch asynchron synchron updat scheme dynam simul moreov pew oper also open way encod exot cellular dynam cellular learn implement edg weight regulatori network infer omic data | D053263 | T044 |
36,215,323 | month sulfadoxinepyrimethamin amodiaquin dihydroartemisinin piperaquin malaria chemoprevent young kenyan children sickl cell anemia random control trial children sickl cell anemia sca area africa endem malaria transmiss common prescrib malaria chemoprevent chemoprevent regimen vari countri compar efficaci prevent regimen larg unknown | D000755;D000962;D037621;D008288;D016778 | T121;T047;T109 |
36,215,322 | chao synthet microbi communiti predict fundament requir biolog engin move build coordin multicellular system potenti system display chaotic behaviour becom concern therefor understand system show chao import design consider develop methodolog explor potenti chaotic dynam small microbi communiti govern resourc competit intercellular communic competit bacteriocin interact model select pipelin use approxim bayesian comput first identifi oscillatori behaviour rout find chaotic behaviour shown expect find chaotic state relat small synthet microbi system understand govern dynam provid insight control system work first queri exist chaotic behaviour synthet microbi communiti import ramif field biotechnolog bioprocess synthet biolog | D064307;D001430 | T116;T028;T001;T123;T032 |
36,215,321 | impact heat ventil air condit hvac design featur transmiss virus includ novel coronavirus covid systemat review humid aerosol rout pathway transmiss mani virus similar recent evid determin aerosol transmiss sar cov signific consequ public health offici profession sought data regard role heat ventil air condit hvac featur mean mitig transmiss virus particular coronavirus use intern standard systemat review conduct comprehens identifi synthes research examin effect humid transmiss coronavirus influenza result relev studi show increas mid high relat humid rh sar cov associ decreas virus surviv although sar cov result appear consist coronavirus behav increas low mid rh influenza associ decreas persist infect viabil surviv howev effect increas humid mid high influenza consist medium temperatur exposur time associ inconsist result coronavirus influenza adapt humid mitig virus transmiss complex control humid hvac featur practition take account virus type temperatur futur research also consid impact exposur time temperatur medium design experi also work toward standard test procedur clinic trial registr prospero crd | D000086382;D007251 | T047;T067 |
36,215,320 | two tier system select receptor transport protein degrad divers physiolog reli receptor transport protein regul degrad mediat escrt loss function mutat human escrt gene link cancer neurolog disord thought block process howev homolog mutat introduc model organ cell thrive degrad persist suggest mechan compens better understand secondari process studi degrad transport mup receptor ste protein escrt gene vps vps delet saccharomyc cerevisia use live cell imag organell biochemistri find endocytosi remain intact intern protein aberr accumul vacuolar lysosom membran within cell sort degrad intralumen fragment ilf pathway constitut trigger substrat misfold tor activ vivo vitro thus ilf pathway function fail safe layer defens escrt disregard client repres two tier system ensur degrad surfac polytop protein | D029701 | T116 |
36,215,319 | epilp fast flexibl bayesian tool estim time vari reproduct number infecti diseas epidemiolog instantan reproduct number formula see text time vari paramet defin averag number secondari infect generat infect individu time therefor crucial epidemiolog statist assist public health decis maker manag epidem present new bayesian tool epilp robust estim time vari reproduct number propos methodolog smooth epidem curv allow obtain approxim point estim credibl interv formula see text employ renew equat use bayesian p spline coupl laplac approxim condit posterior spline vector two altern approach infer present approach base maximum posteriori argument model hyperparamet deliv estim formula see text second approach base markov chain mont carlo mcmc scheme under langevin dynam effici sampl posterior target distribut case count per unit time assum follow negat binomi distribut account potenti overdispers data would captur classic poisson model furthermor smooth epidem curv plug estim reproduct number obtain renew equat yield close form express formula see text function spline paramet approach extrem fast free arbitrari smooth assumpt epilp appli data sar cov hong kong influenza hn usa sar cov pandem belgium portug denmark franc | D053118;D000086382 | T067;T047;T005 |
36,215,318 | pattern ferroelectr perovskit singl crystal array self power uv photodetector boost combin ferro pyro phototron piezo phototron effect metal halid perovskit ferroelectr possess various physic characterist piezoelectr pyroelectr effect could broaden applic perovskit ferroelectr enhanc optoelectron perform therefor promis combin multipl effect optim perform self power pds herein pattern ferroelectr perovskit pma pbcl microbelt array demonstr pdms templat assist antisolv crystal method perovskit array base flexibl photodetector exhibit fine self power photodetect perform nm illumin much enhanc reproduc compar random distribut singl crystal microbelt base pds furthermor introduc piezo phototron effect perform flexibl pd great enhanc extern tensil strain respons enhanc maw find offer advanc comprehens util various physic characterist ferroelectr novel ferroelectr optoelectron | D010087;D015034 | T121;T197 |
36,215,317 | genom wide associ studi chaga cardiomyopathi identifi new risk locus chromosom associ immun relat protein transcript signatur chronic chaga cardiomyopathi ccc usual develop year first parasit infect one lead caus end stage heart failur latin america despit great inter individu variabl ccc suscept infect individu ever present ccc known predictor diseas develop chronic infect | D002598;D014355;D014349 | T047;T204 |
36,215,315 | explor develop evalu implement complex health intervent prevent earli childhood cari preschool children scope review protocol scope review aim identifi complex health intervent chi prevent earli childhood cari ecc explor level complex identifi chi explor detail develop evalu implement | D003695;D003733 | T093;T058;T032 |
36,215,314 | explor ecolog restor salin alkali land base nbs studi salt resist desalin perform three cash crop soil salin one current global environment problem current research crop salin alkali land focus salt toler less ecolog benefit howev plant environ interact influenc theori use carri natur base solut nbs therefor research crop plant ecolog econom benefit novel valuabl work three wide plant cash crop solanum melongena momordica charantia capsicum annuum select salt stress treatment nacl mmoll physiolog indic chlorophyl solubl protein prolin pro malondialdehyd mda plant soil properti electr conduct ph soil salt content measur result show salin content three plant cultiv soil signific differ p salt stress three crop desalin capac capsicum annuum strongest salt resist desalin capac | D000468;D002212 | T002;T168;T197 |
36,215,313 | inner nuclear membran protein nemp support nuclear envelop open enucl erythroblast nuclear envelop membran protein nemp conserv famili nuclear envelop ne protein resid within inner nuclear membran inm even though nemp knockout ko mice overt normal display pronounc splenomegali phenotyp recent report describ requir ne open erythroblast termin matur led us examin potenti role nemp erythropoiesi report nemp ko mice show peripher blood defect anemia neonat ineffect erythropoiesi splenomegali stress erythropoiesi erythroid lineag nemp ko mice overrepres pronounc apoptosi polychromatophil erythroblast show nemp local ne erythroblast progenitor mechanist discov nemp accumul aggreg local near edg ne open nemp defici lead mark decreas ne open ensu enucl togeth result first time demonstr nemp essenti ne open erythropoiet matur vivo provid first mous model defect erythropoiesi direct link loss inm protein | D009685;D013163 | T026;T033 |
36,215,312 | knockout signal peptid peptidas eye reduc hsv replic eye diseas ocular infect mice previous report knock signal peptid peptidas spp glycoprotein k gk bind partner mous peripher sensori neuron reduc latenc reactiv infect mice without affect primari virus replic eye diseas sinc virus replic eye play essenti role eye diseas generat condit knockout mous lack spp express eye cross pax pair box cre mice intact pax express sppfloxflox mice signific less spp protein express detect eye pax spp mice wt control mice hsv replic eye pax spp mice signific lower wt control mice level gb gk icp transcript cornea trigemin ganglia tg pax spp infect mice also signific lower wt mice corneal scar angiogenesi signific lower pax spp mice wt control mice corneal sensit signific higher pax spp mice compar wt control mice acut viral infect absenc spp eye affect cd express affect cd ifn express eye howev absenc spp latenc reactiv similar pax spp wt control group overal result show delet spp express eye reduc primari virus replic eye reduc cd ifn mrna express reduc eye diseas reduc angiogenesi alter corneal sensit latenc reactiv hsv infect thus block gk bind spp eye may therapeut potenti reduc virus replic eye eye diseas associ virus replic | D018259;D016849;D006561;D005128 | T047;T005 |
36,215,311 | cultur differ vocal express analysi effect task languag stimulus relat factor cultur context shape way emot express social interpret build previous research look cultur differ judgement facial express examin listen recogn speech embed emot express make infer speaker feel relat vocal display canadian chines particip categor vocal express emot anger fear happi sad express differ intens level three languag english mandarin hindi two addit task particip rate intens emot express intens speaker feel stimuli group accur recogn emot produc nativ languag group advantag howev canadian chines particip judg speaker feel equival intens actual display especi high arous negat emot suggest similar infer rule appli vocal express two cultur task result provid new insight peopl categor interpret speech embed vocal express versus facial express cultur factor play | D007802;D014831 | T040;T171 |
36,215,310 | genom wide screen identifi scai modul uv induc replic stress respons helix destabil dna lesion induc environment mutagen uv light caus genom instabl strong block progress dna replic fork rfs block rf singl strand dna ssdna accumul rapid bound replic protein rpa complex stretch rpa ssdna constitut platform recruitmentactiv critic factor promot dna synthesi restart howev period sever replic stress rpa avail may becom limit due inordin sequestr multifunct complex ssdna therebi negat impact multipl vital rpa depend process perform genom wide screen identifi factor restrict accumul rpa ssdna uv induc replic stress approach reveal expect hit act pathway nucleotid excis repair transles dna synthesi intra phase checkpoint also identifi scai whose role replic stress respons previous unappreci upon uv exposur scai knock caus elev accumul rpa ssdna phase accompani reduc cell surviv compromis rf progress effect independ previous report role scai bp depend dna doubl strand break repair also found scai recruit uv damag chromatin deplet promot nascent dna degrad stall rf final provid evid exo major nucleas under ssdna format dna replic defect scai knockout cell consist ii demonstr scai inhibit exo activ ssdna gap vitro taken togeth data establish scai novel regul uv induc replic stress respons human cell | D051716;D004277 | T123;T116;T114 |
36,215,309 | scientif engin practic align ngss perform secondari stage physic teacher studi aim unravel degre scientif engin practic compli ngss next generat scienc standard present perform physic teacher secondari stage taif citi saudi arabia studi also sought identifi effect qualif year experi variabl degre ngss align practic present perform physic teacher studi adopt mix method appli close end questionnair interview questionnair compris indic appli teacher random select interview appli educ supervisor purpos select result reveal follow five practic ask question identifi problem obtain evalu communic inform plan carri investig analyz interpret data involv proof evid rate medium three practic interpret solut design develop use model use mathemat comput think rate weak data analysi educ supervisor interview reveal opinion extent concord questionnair find result also reveal graduat teacher exhibit higher level practic teacher bs degre year experi variabl signific differ teacher use practic conclud teacher physic need reconsid teach practic align ngss studi contribut teacher profession develop effort target align scienc instruct ngss | D000071195 | T097 |
36,215,308 | combin effect institut qualiti capit flow food nutrit secur undernourish sub saharan africa issu relat malnutrit broad defin receiv grow attent recent year connect sustain develop goal also recent unpreced covid pandem time exist complex interact institut capit flow food nutrit secur receiv less attent relev literatur paper estim seri dynam panel data model examin impact institut qualiti capit flow food secur nutrit secur undernourish use panel data ssa countri period one key contribut paper use aggreg disaggreg capit flow examin impact food nutrit secur dimens surpris neglect relev literatur combin interact various type capit flow institut qualiti index construct various govern indic examin impact institut overal nexus final examin impact food nutrit secur also undernourish find clear demonstr import heterogen approach reflect earlier work regard role institut qualiti overal nexus extern capit flow various measur food nutrit secur lead expect interest variat result obtain depend type capit flow interact govern indic | D000086382;D044342 | T047;T067 |
36,215,307 | structur random recept field enabl inform sensori encod brain must repres outsid world anim surviv thrive earli sensori system neural popul divers recept field structur detect import featur input yet signific variabl ignor classic model sensori neuron model neuron recept field random variabl sampl parameter distribut demonstr model two sensori modal use data insect mechanosensor mammalian primari visual cortex approach lead signific theoret connect foundat concept recept field random featur lead theori understand artifici neural network model neuron perform random wavelet transform input remov high frequenc nois boost signal random featur neuron enabl learn fewer train sampl smaller network artifici task structur random model recept field provid unifi mathemat tractabl framework understand sensori encod across spatial tempor domain | D009474;D016571 | T025;T170 |
36,215,306 | postur respiratori function diaphragm assess mode ultrasonographi diaphragm chang posit respiratori excurs postur load howev unclear react lift load breath hold breath simultan voluntari contract abdomin muscl vcam studi analyz diaphragm motion healthi individu various postur respiratori situat | D003964;D012119 | T023;T039 |
36,215,305 | multipl bump enhanc robust nois continu attractor network central function continu attractor network encod coordin accur updat valu path integr network produc local bump activ move coher respons veloc input brain continu attractor believ underli grid cell head direct cell maintain period represent posit orient respect represent achiev number activ bump consequ fewer bump unclear address knowledg gap construct ring attractor network differ bump number character respons three type nois fluctuat input spike nois deviat connect away ideal attractor configur across three type network bump experi less nois driven deviat bump motion translat robust encod linear coordin like posit assum neuron repres fix length matter bump number altern consid encod circular coordin like orient network distanc adjac bump alway map onto degre map bump number signific affect amount error coordin readout simul result intuit explain quantit match unifi theori path integr nois multi bump network thus suppress effect biolog relev nois continu attractor network employ bump encod linear coordin advantag disappear encod circular coordin find provid motiv multipl bump mammalian grid network | D008959;D009474 | T025;T170 |
36,215,304 | surveil contact trace characterist sar cov transmiss educ set northern itali septemb april role school contact spread virus effect school closur control epidem still debat aim quantifi risk transmiss sar cov school set type school characterist index case calendar period provinc reggio emilia itali secondari aim estim speed implement contact trace | D000086382;D000086402 | T047;T067;T005 |
36,215,302 | antisens non code transcript repress pho model gene level promot chromatin structur pervas transcript eukaryot genom generat non code transcript regulatori potenti examin effect non code antisens transcript regul express yeast pho gene paradigmat case gene regul promot chromatin remodel negat role antisens transcript pho gene locus demonstr leverag level overlap antisens transcript specif mutant background express strong promot cis use crispri system furthermor show enhanc elong pho antisens lead repress chromatin conform pho gene promot slowli remodel upon gene induct negat effect antisens transcript pho gene transcript mitig upon inactiv histon deacetylas rpd show pho antisens rna act via histon deacetyl regulatori pathway lead rpd depend decreas recruit rsc chromatin remodel complex pho gene promot upon induct antisens transcript overal data work reveal addit level complex regulatori mechan pho gene express show antisens transcript mediat repress level promot chromatin structur remodel | D029701 | T116 |
36,215,300 | molluscicid antioxid activ silver nanoparticl multi speci snail intermedi host schistosomiasi schistosomiasi also known bilharzia second import parasit diseas malaria present studi aim evalu molluscicid effect silver nanoparticl biomphalaria alexandrina b glabrata oncomelania hupensi snail intermedi host intestin schistosom ie schistosoma mansoni japonicum along chang antioxid enzym | D001700;D053768;D008975;D012552 | T047;T131;T073;T204 |
36,215,298 | cell shape anisotropi contribut self organ feather pattern fidel bird develop tissu self organ varieti pattern structur stabil stochast fluctuat molecular cellular properti molecular factor cell dynam contribut self organ identifi vivo event channel self organ system achiev stabl pattern outcom remain unknown describ natur variat fidel self organ array form feather follicl precursor bird embryo survey skin cell prior tissu self organ perform speci specif ex vivo drug treatment mechan stress test demonstr pattern fidel depend initi amplitud cell anisotropi region develop dermi compet produc pattern use live imag show cell shape anisotropi associ limit increas cell motil sharp precis locat primordia format thus proper pattern geometri result evid mechan initi tissu properti ensur stabil self organ thus reproduc pattern product | D005241;D001717 | T012;T023 |
36,215,297 | impact covid pandem chang temperatur sensit cardiovascular respiratori diseas mortal japan cardiovascular respiratori diseas trigger chang ambient temperatur extrem temperatur studi aim clarifi chang mortal associ temperatur sensit diseas japan covid pandem use data three major citi sapporo citi tokyo ward osaka citi determin diseas mortal rate month mean temperatur april decemb pandem occur result show temperatur sensit diseas death count would increas base confid interv estim past year sapporo increas actual death tokyo increas osaka increas analys mesh popul data covid pandem indic inhibit peopl behaviour outdoor mobil especi older men caus decreas mortal | D000086382;D012120;D012140 | T047;T067 |
36,215,295 | vitro osteoblast activ decreas residu chemic use clean viral inactiv process bone allograft allograft bone tissu long histori use two main way preserv allograft cold freez room temperatur addit clean treatment use chemic chemic consid potenti harm human aim studi assess presenc chemic residu process bone allograft ii compar vitro biocompat allograft frozen allograft presenc chemic residu industri chemic treat bone assess high perform liquid chromatographi hplc extract biocompat analysi perform primari osteoblast cultur wistar rat grown bone disk either frozen f bone group treat supercrit carbon dioxid ad chemic scco bone group industri treat chemic ct bone group cell viabil xtt measur one week cultur osteoblast differenti assess day cultur measur alkalin phosphatas alp activ direct bone disc indirect cell mat vicin bone disc residu chemic use found ct bone group signific differ cell viabil three bone group direct indirect alp activ signific lower ct bone group day cultur p residu chemic substanc use clean bone allograft caus vitro decreas biocompat tissu clean process must develop limit replac chemic favor biocompat | D016025;D010006;D038301 | T059;T061;T025 |
36,215,294 | foster children perspect particip child welfar process meta synthesi qualit studi object meta synthesi systemat synthesis qualit research explor foster children perspect particip child welfar process search conduct medlin ovid embas psycinfo social scienc citat index children non kinship foster care set high incom middl incom low incom countri self report experi care remov home foster famili process placement breakdown elig inclus select studi took place high incom countri total citat identifi articl includ meta synthesi studi summar view children children foster care two week year find synthes facet children particip eg ask vs make decis well children perceiv barrier facilit particip main prioriti children qualiti relationship especi term valu eg fair honesti inclus one way particip child welfar process better anoth children clear express desir passiv listen role other indic desir activ role decis make howev meaning adult foster children live respons act way strengthen emphasi children need voic | D000073921 | T099 |
36,215,292 | role internet use relationship occup status depress emerg inform communic technolog ict societi integr digit innov imagin creativ solv social problem creat social valu age societi especi china penetr rate internet use becom promin nevertheless role internet use relationship occup status depress remain unknown purpos studi estim internet use moder relationship occup status depress sampl older adult china | D003863;D000084362 | T169;T184;T048 |
36,215,291 | deep learn reduc time effort requir manual segment reconstruct mri rotat cuff tear use mri diagnost tool gain popular field orthoped although dimension mri offer intuit visual better facilit treatment plan dimension mri manual segment visual time consum lack reproduc recent advanc deep learn may provid solut problem process automat segment purpos studi develop autom semant segment mri imag rotat cuff tear use convolut neural network visual model relat anatom structur | D000077321;D000070636 | T047;T066;T037;T033 |
36,215,290 | studi properti mud film deriv natur weather red bed soil pressureless condit mulch film import materi ecolog restor desert control salin alkali land improv slope green protect present solid liquid mulch film main made man made materi great impact ecolog environ expens natur weather red bed soil mud film appli construct industri advantag environment friendli low cost howev present film format need occur pressur complex process result great applic limit difficult popular appli natur mud film field ecolog restor therefor explor high qualiti film format pressureless condit key applic natur weather red bed soil mud film field ecolog restor solv problem paper take natur weather red bed soil without addit design carri mud film form test natur weather red bed soil comparison test bentonit pressureless condit test influenc mud particl gradat viscos moistur content film form effect optim mud film form ratio studi thick water resist compress resist acid alkali resist test compar intern standard result show natur weather red bed soil form mud film pressureless condit optim high qualiti film correspond mud viscos pas water content content particl particl size smaller mm compar intern standard bentonit natur weather red bed soil mud film meet ecolog restor standard better water resist compress resist acid alkali resist bentonit mud film advantag wide distribut low cost simpl sampl prepar wide applic rang therefor weather red bed soil mud film film technolog obvious compar advantag introduc field ecolog restor broad prospect | D012987;D012989 | T167;T131 |
36,215,289 | efficaci toler combin pemetrex base chemotherapi gefitinib first line treatment non small cell lung cancer mutat egfr pool analysi random clinic trial epiderm growth factor receptor egfr tyrosin kinas inhibitor tki monotherapi standard care treat advanc non small cell lung cancer nsclc nevertheless whether ad pemetrex base chemotherapi egfr tki target therapi further prolong surviv outcom improv respons remain controversi therefor conduct pool analysi compar efficaci toler gefitinib plus pemetrex base chemotherapi gefitinib alon first line treatment advanc nsclc patient mutat egfr | D002289;D000077156;D008175;D000068437;D047428 | T191;T109;T116;T121 |
36,215,288 | covid outcom patient take cardioprotect medic coronavirus diseas covid caus worldwid pandem led five million death mani cardiovascular risk factor eg obes diabet associ increas risk advers outcom covid hand suggest medic use treat cardiometabol condit may protect effect patient covid | D000086382;D019161;D008687 | T121;T047;T109;T067 |
36,215,287 | cognit behavior function two neurogenet disord differ aspect duchenn muscular dystrophi neurofibromatosi type presenc neurocognit behavior problem common featur various neurogenet disord duchenn muscular dystrophi dmd problem link mutat along dystrophin gene affect differ brain dystrophin isoform howev compar cognit behavior problem found neurofibromatosi type nf studi aim assess disord specif differ cognit behavior dmd nf retrospect data male patient dmd age match data male patient nf patient group underw neurocognit assess regular clinic care intellectu abil sequenti simultan process verbal memori sustain attent evalu addit parent teacher complet behavior questionnair male dmd exhibit low intellectu abil sequenti process problem outcom signific differ male nf simultan process verbal memori sustain attent outcom equal group outcom questionnair display higher rate aggress behavior dmd wherea nf higher rate problem think withdrawn social behavior notic neurogenet disord dmd nf averag overlap cognit behavior problem notic suggest caus gene mutat result lack one specif protein | D020388;D009456 | T191;T047 |
36,215,286 | comparison test done tuberculosi case detect xpert mtbrif xpert mtbrif ultra uganda uganda introduc xpert mtbrif assay tb diagnost algorithm januari juli assay replac xpert mtbrif ultra assay set compar test done tuberculosi case detect xpert mtbrif xpert mtbrif ultra assay uganda | D000904;D009169;D014376 | T007;T047;T195 |
36,215,285 | immunomodulatori effect chicken cathelicidin primari hepat cell co cultur model cathelicidin antimicrobi peptid amp produc part innat immun system chicken might new candid combat infect inflamm within gut liver axi studi hepat immun respons high import liver primarili expos gut deriv pathogen associ molecular pattern aim present studi assess effect chicken cathelicidin alon combin lipoteicho acid lta phorbol myrist acet pma cell viabil immun respons redox homeostasi primari hepatocyt non parenchym cell co cultur chicken origin concentr cathelicidin decreas cellular metabol activ increas extracellular lactat dehydrogenas ldh activ reflect reduc membran integr neither lta pma affect paramet combin lta cathelicidin could influenc ldh activ cathelicidin increas effect concentr proinflammatori cxcli interferon ifn anti inflammatori il meanwhil macrophag coloni stimul factor csf play complex role inflamm diminish amp lta elev ifn decreas csf level pma increas concentr csf concentr cathelicidin increas ho releas cell concentr malondialdehyd lipid peroxid marker affect find give evid cathelicidin also possess anti inflammatori effect reflect allevi lta trigger ifn elev reduc csf product induc pma base present result cathelicidin play substanti role modul hepat immun respons multifacet mode action found dose depend effect metabol activ membran integr reactiv oxygen speci product indic use excess high concentr contribut cell damag conclus cathelicidin seem promis candid futur immunomodul drug develop attempt reduc applic antibiot | D002645;D016173 | T012;T116;T129 |
36,215,284 | verbal psycholog violenc women turkey determin verbal psycholog violenc women consid import sociolog legal problem serious threat within context basic human right aim studi detect factor affect verbal psycholog violenc women turkey develop countri micro data set nation research domest violenc women turkey conduct hacettep univers institut popul studi employ studi factor affect women exposur verbal psycholog violenc husband partner turkey determin use binari logist binari probit regress analys women whose husband partner cheat use alcohol expos verbal psycholog violenc compar other addit women expos physic econom sexual violenc expos verbal psycholog violenc compar other exposur violenc first degre relat increas possibl exposur verbal psycholog violenc effect result achiev priorit women likeli expos violenc polici aim prevent act verbal violenc women countri studi verbal psycholog violenc women therefor use conduct relev studi differ perspect | D017579;D012742 | T054;T037;T048 |
36,215,282 | protein phosphatas catalyt subunit stppacb enhanc suscept phytophthora infestan senesc potato serinethreonin protein phosphatas type ppa involv sever physiolog respons plant play import role development program stress respons hormon signal six ppa catalyt subunit stppac identifi cultiv potato transgen potato plant constitut overexpress catalyt subunit stppacb stppacb oe develop determin physiolog role respons stppacb oe plant oomycet phytophthora infestan causal agent late blight evalu found overexpress stppacb enhanc suscept pathogen bioinformat biochem molecular analys reveal stppacb posit regul development pathogen induc senesc p infestan infect promot senesc like induct stppacb express | D055750;D011198 | T168;T002;T204 |
36,215,281 | covid pandem effect prehospit madrid stroke code metric diagnost accuraci studi investig effect covid pandem pre hospit stroke code protocol first wave spain one affect countri sar cov coronavirus diseas pandem health catastroph overshadow patholog acut stroke lead caus death among women lead caus disabl among adult interfer stroke code protocol delay administr reperfus treatment acut ischem stroke lead wors patient prognosi aim compar perform stroke code first wave pandem period previous year | D000086382;D004632;D020521 | T047;T093;T061;T058;T067 |
36,215,280 | effect assist reproduct technolog sever matern morbid risk singleton multipl birth korea nationwid popul base cohort studi whether infertil treatment predict sever matern morbid singleton twin pregnanc controversi conduct nationwid popul base cohort studi compar pregnanc conceiv assist reproduct technolog treatment intrauterin insemin vitro fertil unassist pregnanc | D047928 | T046 |
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