PMID
int64 35.7M
36.4M
| Title/Abstract
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36,329,401
|
outcom predictor function mental health health relat qualiti life adult born low birth weight prospect longitudin cohort studi low birth weight vlbw g associ multipl short long term complic studi aim examin outcom predictor function mental health health relat qualiti life adult born vlbw
|
D011788;D008603
|
T078;T041
|
36,329,400
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global region nation burden diseas studi atrial fibrillationflutt result global burden diseas studi data global burden diseas injuri risk factor studi gbd use assess burden chang preval incid death disabl adjust life year risk factor atrial fibrillationflutt countri territori
|
D001281;D006973
|
T047;T046
|
36,329,399
|
trade conserv biolog variat batch effect remov deep generat model singl cell transcriptom singl cell rna sequenc scrna seq technolog contribut signific divers research area biolog cancer develop sinc scrna seq data high dimension common strategi learn low dimension latent represent better understand overal structur data work build upon scvi power deep generat model learn biolog meaning latent represent limit explicit control batch effect rather priorit batch effect remov conserv biolog variat vice versa goal provid bird eye view trade off two conflict object specif use well establish concept pareto front econom engin seek learn entir trade curv conserv biolog variat remov batch effect
|
D059467;D000465
|
T081;T170;T086
|
36,329,398
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health manag malnourish elder primari health care scope review aim studi first review direct primari health care identifi screen practic health outcom relat care provid famili health team malnourish elder peoplepopul
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D011788;D044342
|
T078;T047
|
36,329,397
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identifi optim candid postop adjuv therapi among region persistentrecurr nasopharyng carcinoma patient neck dissect analyz clinic outcom patient region persistentrecurr nasopharyng carcinoma npc receiv neck dissect evalu clinic benefit postop adjuv therapi pat base patient posit lymph node count plns extracapsular spread ec preoper plasma ebv dna level
|
D009303;D020031
|
T047;T191
|
36,329,396
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cardiac distress inventori new measur psychosoci distress associ acut cardiac event mani challeng pose experi heart attack heart surgeri characteris cardiac distress span multipl psychosoci domain incorpor patient respons physic affect cognit behaviour social symptom experi relat cardiac event recoveri although measur psycholog emot impact cardiac event exist none provid comprehens assess cardiac distress address gap studi aim develop cardiac distress inventori cdi use best practic instrument design
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D013315
|
T048
|
36,329,395
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effect postpartum intervent aim improv women mental health medic complic pregnanc systemat review meta analysi postpartum mental disord includ depress anxieti common medic complic pregnanc preeclampsia gestat diabet thought increas risk mental disord postpartum howev unclear intervent may effect prevent andor treat postpartum mental disord follow medic complic pregnanc aim systemat review publish literatur effect postpartum intervent improv women mental health medic complic pregnanc
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D019052;D011248
|
T046;T048
|
36,329,394
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prognost signific prognost nutrit index system immun inflamm index patient curat breast cancer resect retrospect cohort studi nutrit status inflamm close associ poor outcom malign tumor howev prognost impact postop variabl breast cancer bc remain inconclus aim determin whether prognost nutrit index pni system immun inflamm index sii neutrophil lymphocyt ratio nlr platelet lymphocyt ratio plr affect two long term outcom among patient curat resect bc
|
D015596;D001943
|
T060;T081;T170;T191
|
36,329,393
|
cone beam comput tomographi mandatori procedur adren venous sampl primari hyperaldosteron investig necess cone beam comput tomographi cbct adren venous sampl av
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D006929
|
T047
|
36,329,392
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effect vitreomacular interfac neovascular age relat macular degener treat intravitr inject anti vegf purpos studi studi effect repeat intravitr inject anti vascular endotheli growth factor anti vegf drug vitreomacular interfac
|
D020533;D008268
|
T123;T121;T116;T039;T047
|
36,329,391
|
novel gria variant patient atyp autism spectrum disord psychiatr symptom case report sequenc technolog advanc recent year seri synaps relat gene variant report associ autism spectrum disord asd amino hydroxi methyl isoxazol propion acid ampa receptor subtyp ionotrop glutam receptor whose number composit chang regul strength plastic synaps
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D000067877
|
T048
|
36,329,389
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multi level perspect perceiv unmet need home support home dwell older adult swiss context secondari data analysi popul studi unmet need home support occur support servic perceiv older peopl need receiv meet need negat impact older adult qualiti life increas health care util hospit institution death date consensus defin assess unmet need parallel previous research factor associ unmet need home support most focus factor micro level thus paper aim identifi preval unmet need home support among home dwell older popul factor macro meso micro level contribut
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D006301;D011788
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T078;T098;T080
|
36,329,388
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serum zinc valu ankl brachial index mortal hemodialysi patient atherosclerot state haemodialysi hd patient may influenc heavi metal purpos studi assess relationship serum zinc zn ankl brachial index abi non invas diagnost tool atherosclerosi mortal chronic haemodialysi hd patient
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D006973;D050197;D003920
|
T047;T046
|
36,329,386
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effect graze disturb floral display pollen limit plant pollin effici desert stepp graze disturb usual affect floral display pollin effici desert stepp may caus pollen limit insect pollin plant effect pollin essenti reproduct success insect pollin plant insuffici pollen transfer may result pollen limit caragana microphylla lam arid region shrub ecolog import studi conduct graze disturb influenc pollen limit pollin effici c microphylla quantifi effect differ graze intens floral display pollin visit frequenc seed product urat desert stepp
|
D035264;D007313;D011058;D054817;D060434
|
T008;T040;T204;T002
|
36,329,384
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biomed name entiti recognit combin featur attent fulli share multi task learn biomed name entiti recognit bioner basic import task biomed text mine purpos automat recogn classifi biomed entiti perform bioner system direct impact downstream applic recent deep neural network especi pre train languag model made great progress bioner howev lack high qualiti larg scale annot data relev extern knowledg capabl bioner system remain limit
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D057225;D016571
|
T170;T066
|
36,329,383
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morpholog specif analysi imag base model airway fill difficult airway purpos studi analyz posit specif morpholog chang upper airway assess impact chang difficult airway intub
|
D021621;D012137
|
T073;T060;T022;T062;T023
|
36,329,382
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popul dynam demograph histori eurasian collar lem ancient dna studi suggest late pleistocen climat chang signific effect popul dynam arctic speci eurasian collar lem dicrostonyx torquatus keyston speci arctic ecosystem earlier studi indic past climat fluctuat import driver past popul dynam speci
|
D017753;D003411
|
T070;T082;T015
|
36,329,381
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case multipl penil schwannoma year old man present painless nodul right ventral aspect penil shaft root patient visit hospit complain mass grow physic examin cm mass without tender palpat isoecho mass cm size observ ultrasonographi inhomogen high signal intens observ weight magnet reson imag needl biopsi reveal schwannoma surgeri excis tumor anoth small tumor detect tumor resect tumor diagnos schwannoma patholog examin case penil schwannoma report eight multipl tumor case difficult detect small tumor preoper diagnosi therefor recommend care observ surgeri
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D009442;D010412
|
T191
|
36,329,380
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use ascit fluid analysi diagnosi intraperiton bladder ruptur case report inebri year old woman histori hysterectomi present emerg depart abdomin pain patient receiv hydrat acetaminophen led symptom resolut patient return sever abdomin pain hour later comput tomographi ct reveal larg volum ascit bladder wall disrupt ascit fluid analysi show elev creatinin cre level mgdl ascit serum cre ratio indic urinari ascit secondari bladder ruptur patient diagnos intraperiton bladder ruptur underw success conserv treatment use indwel urinari cathet
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D001743;D001745
|
T023;T047
|
36,329,379
|
comparison periop outcom open robot assist laparoscop radic cystectomi compar periop outcom open orc robot assist laparoscop radic cystectomi rarc patient bladder cancer retrospect investig intraop day postop complic orc rarc perform march septemb base medic record periop complic categor accord clavien dindo classif use propens score match adjust inher bias differ patient characterist baselin includ gender age preoper chemotherapi patholog classif surgeri time rarc signific shorter orc blood transfus signific less frequent rarc orc vs p rate overal complic grade iiiiv lower rarc orc p preval periop urinari tract infect ileus abscessinfecti cyst similar orc rarc patient underw rarc complic rate similar extracorpor intracorpor urinari divers compar orc rarc benefici reduc blood loss sever complic
|
D012371;D065287;D001749;D010535
|
T061;T090;T060;T191
|
36,329,378
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use immunostain score predict respons singl agent nivolumab patient metastat renal cell carcinoma although sever biomark identifi predict prognosi renal cell carcinoma rcc evid base biomark predict respons immun checkpoint inhibitor studi focus lymphocyt tumor cell tumor microenviron investig whether immunostain score could predict best overal respons evalu patient metastat rcc mrcc treat nivolumab monotherapi august juli perform immunostain cd cell tia pd l hla class rcc tissu assign score maximum point defin histolog score best overal respons nivolumab observ patient complet respons cr patient partial respons pr patient stabl diseas sd patient progress diseas pd signific differ patient background crprsd group patient pd group patient cd cell signific higher tia posit cell tend higher crprsd group cd cell p tia p pd l p hla class p univari analysi histolog score tend contribut best overal respons nivolumab p signific differ overal surviv cancer specif surviv nivolumab administr two group patient histolog score histolog score conclus immunostain score base cd cell may abl predict efficaci singl agent nivolumab patient mrcc
|
D002292;D000074322;D007680
|
T121;T129;T191;T116
|
36,329,360
|
model month refer evapotranspir process turkey applic machin learn method studi predict power three differ machin learn ml base approach name multi gene genet program mggp model tree mtree k nearest neighbor algorithm knn long term month refer evapotranspir et predict investig input data consist month solar radiat r maximum air temperatur max wind speed w deriv meteorolog station turkey differ input combin creat analyz model perform evalu use criteria nash sutcliff effici kling gupta effici relat root mean squar error mean absolut percentag error determin coeffici moreov taylor radar boxplot diagram creat determin mggp model outperform mtree knn model equat obtain mggp model best perform combin r max w present best weather condit obtain mjm c ms r max w respect also found r potent input variabl et estim w weakest
|
D004784;D000069550
|
T066;T057
|
36,329,346
|
role indol acet acid iaa produc endophyt bacteria recoveri plant growth surviv abil sugarcan infect white leaf diseas swld indol acet acid produc rhizospher endophyt bacteria promot plant growth effect bacteri iaa produc bip plant growth recoveri sugarcan seedl infect phytoplasma caus white leaf diseas swld examin fifti five endophyt bacteria isol rice root collect mekong river delta vietnam seven isol show indol acet acid product cultur medium supplement tryptophan interest two bc btii produc highest indol acet acid day cultur base rrna sequenc phylogenet analysi bc btii isol identifi delftia lacustri rahnella aquatili respect plant growth induc bc btii isol show statist signific differ height root length fresh weight rice seedl compar non treatment control treatment two bacteri isol swld infect sugarcan plant also show differ height sugarcan seedl gradual symptom exposur decreas plant mortal compar non treatment control bip shown effici biofertil inocul promot plant growth also amelior damag caus phytoplasma associ diseas sugarcan seedl stage
|
D031786;D012275
|
T168;T002
|
36,329,344
|
bio prospect endospor base formul bacillus sp bst possess antimicrobi gene manag soil born diseas tomato tomato affect various diseas caus econom loss farm communiti present studi twenti isol bacillus sp isol rhizospher tomato screen soil born pathogen viz pythium aphanidermatum fusarium oxysporum f sp lycopersici fol sclerotium rolfsii mk tomato result reveal three bacillus sp viz bst bst bst promis reduc myceli growth pathogen reduct compar control vitro isol possess antimicrobi peptid gene detect pcr novel compound secondari metabolit respons antifung action identifi gc ms ftir analysi endospor isol bacillus sp bst standard develop formul pot cultur experi reveal sequenti applic endospor base bioformul seed treatment mlkg seedl dip mllit soil applic day mlpot along foliar spray day record lowest diseas incid wilt collar rot respect inocul control field experi reveal sequenti applic endospor base formul bacillus sp bst seed treatment mlkg seedl dip mllit soil applic mlacr day transplant dat along foliar spray dat record lowest wilt diseas incid percent percent control
|
D018551;D001407;D005670
|
T168;T007;T004;T002
|
36,329,341
|
proliposom base nanostrategi challeng develop drug deliveri system mani attempt made refin liposom stabil payn et al develop approach proliposom derelict physicochem instabl confront liposom suspens ie fusion aggreg hydrolysi oxid review attempt cover differ aspect proliposom along type prepar method review also focus scope proliposom nano base drug deliveri system subsequ applic attempt made cover facet proliposom composit clinic trial extens scientif data proliposom provid substanti shred evid huge deliveri potenti
|
D016503;D008081
|
T074;T109
|
36,329,340
|
genom character twelv lytic bacteriophag infect midgut bacteria aed aegypti mosquito born diseas malaria dengu global sever public health threat due lack effici control method altern approach decreas arbovir transmit diseas priorit reduc morbid mortal everi endem region mosquito midgut bacteria play essenti role physiolog develop fit arthropod vectori capac bacteriophag virus infect bacteria consid promis biocontrol method elimin midgut microbiota play essenti role mosquito health isol identifi bacteria mosquito midgut belong genera mesobacillus enterobact klebsiella microbacterium micrococcus pantoea serratia staphylococcus main twelv phage lytic activ enterobact klebsiella pantoea also isol phage show doubl strand dna genom rang bp taxonom classifi member drexlervirida famili molineuxvirina studiervirina vequintavirina subfamili open read frame associ phage structur pack host lysi dna metabol addit function predict phage genom trnas predict five phage genom addit life cycl predict virul phage antibiot resist virul allergen lysogen gene found either genom find suggest phage biocontrol potenti howev necessari elucid specif bacteri host role phage abil serv effect vector control
|
D001435;D000330;D020636
|
T005;T007;T204
|
36,329,339
|
tackl challeng develop microneedl base electrochem sensor microneedl provid uniqu advantag biomed area particular biosens opportun minim invas conveni detect review introduc concept electrochem microneedl base sensor minim invas analysi togeth insight skin compart design success microneedl discuss requir develop microneedl base biosensor includ electr electrochem behavior materi metal nanomateri conduct polym key factor sensit biosensor emphas immobil strategi attach biorecognit element electrod materi moreov detail advanc techniqu requir state art fabric materi realiz porous biodegrad antifoul materi enhanc biosens perform also emphas studi cytotox damag skin elucid biocompat potenti furthermor highlight latest advanc microneedl publish review also includ overview key remain obstacl opportun develop push advanc continu conclus outlook status laboratori commerci avail ad prospect microneedl sensor integr close loop system biodevic divers applic eg detect therapi review discuss concept electrochem microneedl base sensor minim invas monitor discuss requir includ geometri mechan electr electrochem properti immobil strategi illustr advanc techniqu materi enrich biosensor featur eg poros dissolv abil anti foul capabl concern toxic highlight also illustr recent applic outlook recent publish studi exploit microneedl base biosensor
|
D015374;D049329
|
T059;T073;T075
|
36,329,338
|
evalu wearabl ear sensor temperatur heart rate monitor pilot studi context covid pandem wearabl sensor import earli detect critic ill especi covid outpati sought determin pilot studi whether wearabl ear sensor continu bodi temperatur heart rate monitor cosinuss compani munich suffici accur bodi temperatur heart rate monitor compar sever anesthesiolog standard care monitor devic urinari bladder zero heat flux thermomet ecg evalu ear sensor non cardiac surgeri german clinic trial regist reg drks limit agreement loa base bland altman analysi use studi agreement ear sensor refer method estim loa cosinuss one bladder temperatur monitor c confid interv lower loa upper loa c confid interv lower loa upper loa cosinuss one zero heat flux temperatur monitor cosinuss one temperatur monitor within c limit bladder zero heat flux monitor respect estim loa cosinuss one ecg heart rate monitor bpm confid interv lower loa upper loa proport detect differ within bpm bodi temperatur heart rate reliabl measur wearabl ear sensor
|
D000086382;D000076251
|
T047;T073;T067
|
36,329,335
|
optim product medic signific enzym l asparaginas submerg solid state ferment agricultur wast l asparaginas prime medic signific due chemotherapeut applic action wide rang diseas l asparaginas obtain commerci produc bacteri strain caus anaphylaxi sensit reaction side effect overcom issu eukaryot like fungi use produc l asparaginas penicillium lilacinum explor enhanc product statist optim ferment approach first signific ferment paramet influenc product screen plackett burman approach thereaft respons surfac methodolog rsm employ achiev higher product l asparaginas specifi ferment condit studi explor submerg smf solid state ssf ferment condit put forward compar analysi best suitabl ferment condit enhanc product l asparaginas plackett burman optim result suggest ph l asparagin ammonium nitrat temperatur signific affect enzym product smf condit wherea wheat bran arhar bran kulthi bran temperatur identifi signific process paramet ssf final enzym activ obtain smf iuml ugd ssf implic rsm statist optim tool foster fold fold enzym activ smf ssf respect studi suggest l asparaginas effici produc use p lilacinum optim ssf condit
|
D001215;D005658
|
T121;T004;T126;T116
|
36,329,334
|
quantit assay sar cov rna level proinflammatori protein gene transcript peripher blood leukocyt novel coronavirus infect possibl find persist sar cov viral particl human peripher blood leukocyt novel coronavirus infect shown result droplet digit pcr show examin subject copi nsp sar cov gene month infect presenc transcript peripher blood leukocyt associ reduc express foxp gene increas level ror gene mrna copi number nsp gene negat correl level foxp gene mrna r p show posit correl dancr long non code rna r p sar cov posit healthi individu level tlr nlrp ilb gene transcript higher sar cov negat donor presenc sar cov persist form probabl associ impair immunosuppress develop chronic inflamm appar healthi volunt new coronavirus infect
|
D000086402;D000086382
|
T005;T067;T047
|
36,329,333
|
role place thanatoradiolog studi patholog examin fetus newborn analysi publish data possibl use postmortem radiat studi perinatolog carri result thanatoradiolog studi bodi dead fetus newborn present possibl postmortem radiat studi differenti diagnosi stillborn deceas newborn evalu sever macer time intrauterin fetal death detect patholog chang brain spinal cord respiratori digest organ cardiovascular urinari system demonstr conclud postmortem ct high diagnost effici studi bone skeleton free fluid accumul serous caviti gas vessel tissu dead fetus deceas newborn advantag postmortem mri effect visual intern organ soft tissu allow assess topographi size well identifi wide rang patholog chang comprehens object analysi bodi stillborn deceas newborn combin use imag method ct mri requir time thanatoradiolog use part comprehens patholog studi substitut tradit autopsi
|
D005313;D005333
|
T019;T046;T018;T024
|
36,329,332
|
effect combin action neutron proton radiat pool breast cancer stem cell express stem gene vitro radiat respons cancer stem cell studi two breast cancer cell line lumin mcf tripl negat mda mb subtyp relat number cd cd low cancer stem cell mcf line increas time influenc irradi dose gy p comparison control howev signific chang found relat number cancer stem cell express level oct nanog sox gene neutron proton beam irradi combin action total equieffect dose gy comparison control cell line absolut number cancer stem cell decreas influenc neutron proton radiat comparison control p cell line time effect sequenti exposur neutron proton radiat size cancer stem cell pool depend molecular subtyp cancer cell addit interact observ mcf line antagonist one mda mb line coeffici synerg respect
|
D011522;D001943
|
T196;T191
|
36,329,327
|
decad forest dynam log unlog site uppangala western ghat india select log disrupt forest chang structur speci composit long term monitor help identifi factor influenc aid design manag plan conduct quantit assess tree cm girth breast height four ha plot log two ha plot adjac unlog compart uppangala forest continuum western ghat india compar structur composit chang decad altogeth four speci disappear three speci newli recruit mean speci rich stem densiti forest site decreas log plot show slight increas basal area biomass wherea unlog plot show declin basal area biomass compar unlog plot demograph rate higher log forest site across six individu plot growth rate vari signific owe wood densiti forest strata categori non metric multidimension scale nmds identifi three group signific differ speci composit log unlog plot distinct composit except one plot although speci rich stem divers remain stabl speci composit differ year log impact log still evid forest
|
D016468;D014329
|
T090;T070
|
36,329,326
|
pseudogen bmeab defici brucella melitensi contribut epitop format potenti virul mice infect model wide acknowledg pseudogen play import role bacteri diversif evolut particip gene regul rna interfer rnai howev function pseudogen brucella spp remain poor understood warrant studiesto comprehens analyz function pseudogen bmeab brucella melitensi strain bmeab frame delet mutant strain construct phenotyp mutant strain growth characterist bacteri virul assess mice infect model final itraq analysi perform investig gene express profil affect pseudogen bmeab studi found bmeab delet exhibit increas agglutin monospecif sera mous model chronic infect bmeab delet strain display increas colon spleen compar wild type pathogen itraq assay reveal protein differenti express bmeab delet wild type strain addit delet bmeab signific increas express protein involv denitrif pathway iron metabol sever transcript regul might caus increas virul mutant strain conclus studi preliminari uncov function pseudogen bmeab brucella melitensi provid novel insight studi pathogenesi brucella strain
|
D017347;D002006
|
T047;T007
|
36,329,321
|
unlock promis mrna therapeut extraordinari success mrna vaccin coronavirus diseas covid renew interest mrna mean deliv therapeut protein earli clinic trial mrna therapeut includ studi paracrin vascular endotheli growth factor vegf mrna heart failur crispr cas mrna congenit liver specif storag diseas howev seri challeng remain address mrna establish general therapeut modal broad relev rare common diseas array new technolog develop surmount challeng includ approach optim mrna cargo lipid carrier inher tissu tropism vivo percutan deliveri system judici integr advanc may unlock promis biolog target mrna therapeut beyond vaccin immunostimulatori agent treatment divers clinic indic
|
D042461;D000086382
|
T123;T047;T116;T067
|
36,329,318
|
effect medicin plant fungal communiti structur function hospit grassplot soil hospit grassplot soil import repositori pathogen fungi expos hospit environ diffus fungi contain soil particl air increas risk nosocomi fungal infect studi perspect soil microb plant holobiont four medicin plant mirabili jalapa artemisia argyi viola philippica plantago depressa use materi base high throughput amplicon sequenc simul pot experi explor effect medicin plant fungal communiti hospit grassplot soil order provid new explor hospit grassplot soil remedi result show fungal communiti ecolog guild primari test soil main pathogen abund anim pathogen potenti threat human reach plant medicin plant composit function soil fungal communiti chang signific although chang vari plant speci growth stage sampl collect pot experi show pathogen abund decreas saprotroph abund increas addit core fungal genera defin pot sampl present primari test soil mani human potenti pathogen find impli idea enhanc soil qualiti hospit grassplot soil plant specif plant feasibl howev initi fungal communiti hospit grassplot soil certain stabil difficult complet elimin threat pathogen fungi plant medicin plant
|
D000072761;D010946;D039282
|
T004;T002
|
36,329,315
|
mucilaginibact phenanthrenivoran sp nov novel phenanthren degrad bacterium isol wetland soil bjc gram negat aerob non motil rod shape strain isol permafrost wetland soil sampl bjc oxidas catalas posit produc pale yellow coloni modifi ra agar plate rrna gene sequenc bjc share highest sequenc similar mucilaginibact xinganensi bjc mucilaginibact gotjawali sa mucilaginibact frigoritoleran ft phylogenet analysi reveal bjc form separ lineag togeth strain xinganensi bjc genus mucilaginibact bjc contain menaquinon mk predomin isoprenoid quinin major fatti acid cell iso c sum featur cc iso c oh bjc contain phosphatidylethanolamin two unknown polar lipid six unidentifi phospholipid unidentifi aminolipid genom bjc sequenc use genom analyz iix sequenc platform contig produc total averag g c percentag averag nucleotid ident ani bjc respect xinganensi bjc gotjawali sa frigoritoleran ft respect digit dna dna hybrid ddh valu bjc tree refer strain respect bjc exhibit phenanthren biodegrad activ degrad phenanthren mm medium day cultiv phenotyp chemotaxonom phylogenet genom characterist conclud strain bjc repres novel speci genus mucilaginibact henc name mucilaginibact phenanthrenivoran sp nov propos type strain bjc cgmcc nbrc
|
D012987;D010616
|
T121;T167;T109
|
36,329,312
|
fragment major dam implic futur viabil platypus popul evolutionarili uniqu platypus ornithorhynchus anatinus experienc major declin extinct rang histor recent interact human mediat threat although spend time water platypus move land nevertheless uncertainti remain whether dam barrier movement thus limit gene flow dispers essenti evolut ecolog examin disrupt gene flow platypus group five major dam match four adjac river without major dam genet differenti f st across dam fold higher along similar stretch adjac undam river f st across dam similar differenti adjac river system indic major dam repres major barrier platypus movement furthermor f st group correl year dam built increas everi generat reflect effect barrier platypus genet studi provid evid gene flow restrict jeopardis long term viabil platypus popul group fragment major dam mitig strategi build pass structur transloc upstream downstream dam consid conserv manag plan
|
D010987
|
T015
|
36,329,305
|
progesteron phospholipid gel intramuscular administr prepar situ phase separ long term daili inject progesteron treatment threaten abort sourc consider pain patient reduc frequenc inject improv patient complianc novel inject phospholipid base phase separ gel ppsg prepar use small molecular materi phospholipid medium chain triglycerid mcts ethanol progesteron load ppsgs promot rapid gel format situ via sol gel transform mechan therebi achiev sustain control releas furthermor progesteron distribut oil water interfac layer within oil phase solvent exchang drive phase transit phospholipid vesicl format ruptur like promot drug releas gel degrad drug load mgml progesteron releas could reach within day accord releas curv vitro pharmacokinet studi demonstr progesteron load ppsgs releas drug continu day half life eight time higher progesteron oil solut relat bioavail obtain collect sustain releas properti hydrophob cargo would effect enhanc patient complianc moreov ppsgs promis drug deliveri system high market valu biosafeti given readili access safe excipi
|
D010743;D011374
|
T125;T123;T121;T109
|
36,329,300
|
exposur persist organ pollut alter serum metabolom non obes diabet mice autoimmun disord type diabet td believ caus interplay sever genet environment factor elucid role environment factor metabol immun dysfunct lead autoimmun diseas yet well character
|
D003922;D005466;D003921
|
T047;T050;T109
|
36,329,298
|
isol alpha amylas produc bacteria local region ambala product amylas optim factor use solid state ferment enzym one signific product produc primarili microbi sourc human requir purpos work isol screen optim enzym product solid state ferment present studi amylas produc bacteria isol local region ambala total six sampl taken isol isol among seven isol found amylas produc highest amylas yield obtain isol studi product amylas solid substrat ferment ssf also optim condit increas product amylas molecular biochem character confirm strain alkalihalobacillus clausii observ growth paramet show profound effect product bacterium produc ampl amount iug alpha amylas use wheat bran use ovat one variabl time approach use rsm respons surfac methodolog result fold increas alpha amylas product ie iug
|
D000516;D000681
|
T121;T126;T116
|
36,329,297
|
german guidelin titanium hypersensit implant dentistri consensus statement recommend current lack guidelin clinician regard titanium hypersensit implant dentistri diagnost test epicutan test lymphocyt transform test show inconsist result regard reliabl valid thus evid base consensus recommend regard diagnost therapeut option may help clinic decis make therefor german guidelin titanium hypersensit implant dentistri develop
|
D015921;D006967
|
T074;T046
|
36,329,295
|
divers bioactiv endophyt actinobacteria associ grapevin grapevin trunk diseas gtds signific problem new zealand viticultur endophyt actinobacteria interest potenti biocontrol agent due abil inhibit plant pathogen improv plant growth howev studi investig divers actinobacteria associ grapevin new zealand vineyard bioactiv actinobacteria divers differ sauvignon blanc vine tissu three vineyard convent organ manag differ vine age assess use differ method media forti six endophyt actinobacteria isol isol recov root n leav n shoot internod n isol recov organ n convent n vineyard matur year old n young year old n vine use tissu macer techniqu n actinomycet isol agar intern streptomyc project starch casein media effect actinobacteria isol isol recov belong streptomyc one isol identifi mycolicibacterium forti isol assess antifung activ plant growth promot pgp characterist isol antifung activ test gtd pathogen dactylonectria macrodidyma eutypa lata ilyonectria liriodendri neofusicoccum parvum n luteum eighteen isol exhibit one pgp trait siderophor product n phosphat solubil n indol acet acid product n two strain streptomyc sp luvpk streptomyc sp luvpk exhibit best antifung pgp properti studi reveal divers cultur endophyt actinobacteria grapevin new zealand vineyard biocontrol potenti gtd pathogen
|
D039903;D013302
|
T007
|
36,329,291
|
genom analysi molecular characterist carbapenem resist klebsiella pneumonia strain klebsiella pneumonia import bacterium respons infect acquir hospit communiti multidrug resist virul aim research investig clonal lineag antibiot resist profil virul factor hospit isol carbapenem resist strain fifti carbapenem resist isol phenotyp confirm extend spectrum beta lactamas esbl produc mlst analysi reveal sequenc type isol main belong three clone accord pfge dna pattern pfge pattern good discrimin st profil one isol k pneumonia kpx undergo whole genom sequenc compris one circular chromosom four circular plasmid isol harbor varieti antimicrobi resist virul determin closest relat k pneumonia kpx anoth st clinic isol recov sichuan addit kpc shv tem ctx oqxb qnrs int sul sul iuta iucc rmpa gene present multipl drug resist isol dataset present studi provid genom epidemiolog analysi carbapenem resist k pneumonia hospit set antimicrobi resist profil suggest presenc signific select antibiot pressur appropri surveil essenti develop effect control strategi prevent nosocomi infect
|
D007710;D000073182
|
T047;T007
|
36,329,290
|
lysobact sedimenti sp nov isol sediment reclassif luteimona lumbrici lysobact lumbrici comb nov bacterium design isol sediment pesticid plant shandong provinc pr china strain non motil gram stain negat rod shape grew optim na medium c ph wv nacl strain show highest rrna gene sequenc similar lysobact pocheonensi gsoil follow luteimona lumbrici phylogenet analys base rrna indic strain luteimona lumbrici cluster genus lysobact form subclad lysobact pocheonensi gsoil phylogenet analysi base genom sequenc strain luteimona lumbrici also cluster type strain genus lysobact obtain ani dddh valu luteimona lumbrici respect respiratori quinon ubiquinon q major cellular fatti acid iso c sum featur iso c c c methyl iso c iso c major polar lipid diphosphatidylglycerol phosphatidylglycerol phosphatidylethanolamin unidentifi aminophospholipid unidentifi phospholipid unidentifi lipid genom dna g c content mol accord phenotyp chemotaxonom phylogenet analys strain repres novel speci genus lysobact name lysobact sedimenti sp nov propos strain kctc cctcc ab type strain studi also propos luteimona lumbrici transfer genus lysobact lysobact lumbrici comb nov type strain lysobact lumbrici kctc cctcc ab
|
D053528;D009835;D044166
|
T007;T204
|
36,329,283
|
helicobact pylori gastric cancer progress gastric cancer gc remain fifth common malign tumor third lead caus cancer death despit declin incid mortal worldwid past five decad current role helicobact pylori h pylori develop gc establish effect h pylori mediat interact h pylori pathogen associ molecular pattern pamp pattern recognit receptor prrs locat immun epitheli cell known interact lead generat reactiv oxygen speci ros activ mechan angiogenesi epitheli mesenchym transform emt immunolog toler exclud possibl h pylori may effect induct also mechan gc progress review consid main structur element innat immun system mechan interact h pylori possibl role h pylori gc progress relationship h pylori clinic patholog characterist prognosi gc well data effect erad therapi long term result gc patient treatment
|
D016480;D013274;D016481
|
T047;T007;T191
|
36,329,273
|
novel phocaeicola strain amelior dextran sulfat sodium induc coliti mice previous isol novel phocaeicola strain phocaeicola faecali fxjyne fece healthi human china metagenom analysi reveal distribut fxjyne differ intestin tract differ host aim determin whether fxjyne protect ulcer coliti employ mous model studi dextran sulfat sodium use construct uc model diseas activ index colon length bodi weight chang histolog score use patholog indic assess anti inflammatori effect p faecali fxjyne cytokin level tight junction mrna express level short chain fatti acid scfa concentr also analyz phocaeicola faecali fxjyne could reduc dss induc increas dai score enhanc colon length bodi weight phocaeicola faecali fxjyne could enhanc tj protein concentr modul level cytokin reach level close control group fxjyne could also upregul concentr scfa includ acet butyr base correl analysi four factor includ interleukin il il il level propion concentr relat protect role fxjyne uc mice differ degre accord analysi genom inform potenti protect effect strain fxjyne may associ secret scfa specif gene find suggest oral p faecali fxjyne could help maintain epitheli barrier regul cytokin level secret scfa
|
D003092;D003093
|
T047
|
36,329,272
|
multin delphi consensus end covid public health threat despit notabl scientif medic advanc broader polit socioeconom behaviour factor continu undercut respons covid pandem conven part delphi studi divers multidisciplinari panel academ health non government organ govern expert covid respons countri territori recommend specif action end persist global threat public health panel develop set consensus statement recommend govern health system industri key stakehold across six domain communic health system vaccin prevent treatment care inequ wake near three year fragment global nation respons instruct note three highest rank recommend call adopt whole societi whole govern approach maintain proven prevent measur use vaccin plus approach employ rang public health financi support measur complement vaccin recommend least combin agreement advis govern stakehold improv communic rebuild public trust engag communiti manag pandem respons find studi endors organ global includ point unanim agreement well six recommend disagr provid health social polici action address inadequaci pandem respons help bring public health threat end
|
D000086382
|
T047;T067
|
36,329,271
|
virul profil antimicrobi resist streptococcus agalactia infect colon strain argentina streptococcus agalactia gbs colon agent pregnant women main caus invas neonat infect reason serious diseas non pregnant adult sever virul determin involv pathogenesi includ capsular polysaccharid surfac local protein toxin penicillin consid first choic antibiot treatment prophylaxi erythromycin clindamycin fluoroquinolon recommend altern penicillin allerg gbs carrier patient object investig virul genet characterist antimicrobi suscept gbs colon infect isol recov argentina serotyp ia iii preval one follow ib ii v iv non typeabl relat virul gene screen cpsa cyle hylb lmb scpb preval could postul vaccin epitop bca rib bac hvga spb pi pi pi b detect lesser frequenc signific associ found serotyp virul gene colon infect isol contrari signific associ observ gene preval serotyp la iii cluster analysi show virul profil antimicrobi resist test profil resist tetracyclin resist signific associ colon isol gene tetm ermb confer resist tetracyclin macrolid respect common identifi find show gbs colon infect isol circul argentina share similar featur term serotyp virul gene show high level antimicrobi resist
|
D013292;D013290
|
T047;T007
|
36,329,265
|
season diurnal soil respir dynam differ land manag practic sub tropic highland agroecolog ethiopia tempor dynam soil respir chang respons differ land manag practic well document studi investig effect soil bund month diurnal dynam soil respir rate highland upper blue nile basin ethiopia six plot without soil bund three replic use measur season soil respir plot use measur diurnal soil respir collect season variat data month basi septemb august diurnal soil respir data collect four time daili pm pm week septemb wilcoxon sign rank test show season soil respir rate differ signific p soil bund control plot season plot soil bund season soil respir rate lowest februari mol co mean se highest octob mol co diurnal soil respir rate signific p higher time lowest season variat soil respir influenc soil temperatur negat moistur posit diurnal soil respir signific affect soil temperatur soil moistur studi requir explor differ soil microorgan differ land manag practic affect soil respir rate
|
D012987;D002245
|
T123;T197;T167
|
36,329,262
|
energi sovereignti valu base conceptu analysi achiev energi sovereignti increas gain promin goal energi polit aim paper provid conceptu analysi principl ethic social justic perspect reli literatur food sovereignti identifi compar analysi element energi sovereignti like demand thereaft distinguish uniqu constitu energi sector idea energi sovereignti embrac seri valu among identifi access allow access everyon ii empower recognit develop sustain capabl collabor produc solut orient energi system knowledg effect particip govern iii stewardship sustain abl design manag decentralis renew system view protect environ iv self suffici reduc negat shock exploit busi practis v resili maintain product capac withstand socioeconom polit environment climat shock vi peac establish product system involv hostil relat vii transpar self determin establish democrat decis make mechan give voic previous underrepres group limit corpor takeov viii gender justic acknowledg contribut women elimin barrier empower conceptu framework energi sovereignti present rational draw key valu consid formul polici solut energi sector
|
D012935;D011057
|
T078;T090;T080;T055;T068;T057
|
36,329,261
|
novel probiot lactic acid bacteria vitro bioremedi potenti toxic lead cadmium studi newli isol lactic acid bacteria lab screen potenti bioremedi capac toxic lead pb ii cadmium cd ii bioaccess surviv five strain select eighteen previous isol probiot lab strain base heavi metal resist potenti vitro disc diffus assay five strain evalu vitro explor pb cd bind remov effici use flame atom absorpt spectrophotometri time bioaccess surviv assess dynam vitro gastrointestin digest model result reveal test strain shown high magnitud minimum inhibitori concentr valu rang mgl mm growth inhibit zone result also demonstr signific p remov pb cd among five test lab strain lactobacillus delbrueckii subsp bulgaricus ldmb show highest remov rate pb cd also reveal strain signific reduc pb cd bioaccess respect moreov strain shown signific surviv pb cd rang respect studi recommend immens potenti exploit lab probiot protect human health advers effect pb cd toxic
|
D056546;D019936;D048668
|
T007
|
36,329,259
|
prostaglandin base raav mediat glaucoma gene therapi brown norway rat prostaglandin analog first line treatment open angl glaucoma effect lower intraocular pressur undermin patient non complianc caus atrophi optic nerv sever visual impair herein evalu safeti efficaci recombin adeno associ viral vector mediat gene therapi aim perman lower intraocular pressur de novo biosynthesi prostaglandin f within anterior chamber studi demonstr dose depend reduct intraocular pressur normotens brown norway rat maintain month crucial therapi could temporarili halt type riboswitch activ revert intraocular pressur normal longitudin multimod imag electrophysiolog post mortem histolog reveal therapi well toler low medium dose major advers effect anterior chamber health offer promis altern current treatment strategi lead clinic relev reduct intraocular pressur without need adher daili treatment regimen
|
D005902;D009798;D005901
|
T047
|
36,329,257
|
phenom wide analysi taiwan biobank reveal novel glycemia relat loci genet risk diabet explor complex genet architectur common diseas trait conduct comprehens phewa ten diseas quantit trait communiti base taiwan biobank twb identifi signific associ loci novel loci specif taiwanes popul analys highlight genet pleiotropi loci relat complex diseas associ quantit trait extens analysi glycaem phenotyp td fast glucos hba c perform identifi signific loci four novel genet variant hacl rad ashl gak transcriptom data also strengthen relev find metabol disord thus contribut better understand pathogenesi addit genet risk score construct valid absolut risk predict td taiwanes popul conclus data driven approach without priori hypothesi use novel gene discoveri valid top diseas risk predict uniqu non european popul
|
D055106;D003924
|
T063;T047
|
36,329,256
|
current treatment strategi multidrug resist bacteria review sever bacteria call superbug resist multipl antibiot life threaten special critic ill hospit patient articl provid date treatment strategi employ major superbug like methicillin resist staphylococcus aureus carbapenem resist enterobacteriacea vancomycin resist enterococcus multidrug resist pseudomona aeruginosa multidrug resist escherichia coli pathogen direct therapeut decreas toxic bacteria alter virul factor specif process hand host direct therapeut limit superbug modul immun cell enhanc host cell function modifi diseas patholog sever new antibiot global prioriti superbug come market clinic develop phase medicin plant possess potent secondari metabolit play key role treatment superbug nanotechnolog also emerg promis option combat urgent need continu figur best possibl treatment strategi superbug resist also develop new upcom antibiot futur ration use antibiot mainten proper hygien must practic among patient
|
D055624
|
T007
|
36,329,254
|
vitro studi evalu efficaci ultrason ethanol extract rosmarinus officinali chitosan base nanoparticl eimeria tenella oocyst chicken studi chitosan nanoparticl csnps use nanocarri ultrason ethanol extract rosmarinus officinali ueero new nanoformul eimeria tenella herein csnps synthes ionic gelat method ph csnps ph csnps follow character morpholog size polydispers index pdi surfac charg load effici ueero vitro sporul inhibit assay mgml normal salin solut e tenella conduct result show free csnps ueero csnps cubic spheric shape posit charg averag size nm nm nm nm respect total load effici use uv vis spectrophotomet ph ph vitro sporul inhibit assay reveal ueero csnps ueero csnps show potenti inhibitori effect sporul distort wall sporocyst abnorm dose depend manner accord concentr mgml show best efficaci h ueero free csnps ueero csnps moreov ueero csnps ueero csnps stop sporul h taken togeth ueero csnps ueero csnps best effect e tenella dose depend manner term sporul distort wall sporocyst abnorm
|
D016786;D048271;D027542;D053758
|
T121;T073;T109;T204;T002
|
36,329,253
|
deepfak knee osteoarthr x ray generat adversari neural network deceiv medic expert offer augment potenti automat classif recent develop deep learn impact medic scienc howev new privaci issu regulatori framework hinder medic data share collect deep learn data intens process regulatori limit limit potenti new breakthrough collabor howev generat medic accur synthet data allevi privaci issu potenti augment deep learn pipelin studi present generat adversari neural network capabl generat realist imag knee joint x ray vari osteoarthr sever offer synthet deepfak x ray imag train real imag valid model regard medic accuraci medic expert augment effect osteoarthr sever classif task devis survey real deepfak imag medic expert result show averag deepfak mistaken real revers result signifi suffici deepfak realism deceiv medic expert final deepfak improv classif accuraci osteoarthr sever classif task scarc real data transfer learn addit classif task replac real train data deepfak suffer formula see text loss baselin accuraci classifi real osteoarthr x ray
|
D020370
|
T047
|
36,329,241
|
arriv millet atlant coast northern iberia despit one import crop recent prehistori eurasia arriv exploit millet westernmost part europ still larg underexplor first time report multiprong biomolecular evid millet consumpt along atlant faad northern iberia combin radiocarbon date stabl isotop dental calculus analys human individu found burial site el espinoso cave asturia spain high resolut chronolog framework establish individu place burial cal bc discoveri high c valu bone collagen identif polyhedr starch grain within dental plaqu underlin relev c plant diet highlight time systemat consumpt millet late bronz age data support previous region archaeobotan evid establish precis chronolog dispers millet northern iberia bronz age becom essenti crop arriv maiz america ad studi emphas import multidisciplinari method ascertain origin develop agricultur practic recent prehistori
|
D000066928;D001106
|
T090;T091;T002
|
36,329,239
|
covid vaccin programm effect sar cov relat infect hospit admiss death apulia region itali one year retrospect cohort studi studi report vaccin effect covid outcom concentr main estim one singl type vaccin variant seldom consid wane effect aim estim effect overal covid vaccin programm implement apulia region itali prevent sar cov infect covid relat hospit admiss death alpha delta variant domin period conduct retrospect cohort studi use electron health record person year older resid apulia region assess effect combin use bntb mrna chadox adcov vaccin confirm covid infect hospitalis death fulli partial vaccin person well time sinc vaccin variant cox regress model yield hazard ratio use calcul overal vaccin programm effect januari decemb includ elig person cohort fulli vaccin covid posit end studi period effect programm entir studi period fulli vaccin person covid infect hospitalis death ci ci respect effect covid infect fulli vaccin subject alpha delta period respect ci ci hospitalis ci ci death ci ci wane effect programm regard covid infect delta period stronger alpha ci effect month ci month full vaccin effect hospitalis death delta period wane rapid month full vaccin respect decreas ci ci studi suggest covid vaccin program apulia strong protect covid infect hospitalis death due alpha well delta variant although effect reduc time
|
D000086382;D003428
|
T047;T067
|
36,329,237
|
topograph anatomi albino rat ischiotrochanter muscl group obtur internus gemelli quadratus femori muscl thought postur muscl thus focus research although muscl describ speci detail descript still lack albino rat hypothes rat ischiotrochanter muscl group compar human aim provid detail descript compar rat condit speci includ human hind limb adult male formalin fix albino rat care dissect photo document result compar data speci descript human anatomi gemellus muscl one singl muscl mass origin lesser sciatic notch unnam groov dorsal aspect ischium obtur internus muscl aros inner aspect tabula ischium muscl form continuum insert one complex medial aspect greater trochant quadratus femori muscl origin outer aspect tabula ischium insert distal portion intertrochanter crest dorsal aspect lesser trochant despit minor differ topograph condit muscl compar rat mammal includ human
|
D013848;D006615
|
T023;T029
|
36,329,236
|
whole genom sequenc analysi carbapenem heteroresist klebsiella pneumonia escherichia coli isol carbapenem heteroresist isol misclassifi suscept vitro suscept test lead treatment failur under mechan heteroresist bacteri isol harbor resist suscept subpopul poor understood aim current studi clarifi molecular mechan respons carbapenem heteroresist whole genom shotgun sequenc perform resist suscept subpopul three klebsiella pneumonia one escherichia coli blood isol identifi carbapenem heteroresist popul analysi profil method softwar center genom epidemiolog use identifi genom similar antibiot resist gene multilocus sequenc type mlst core genom mlst cgmlst suscept resist subpopul e coli strain mlst profil mlst cgmlst e coli respect suscept resist subpopul k pneumonia strain exhibit ident mlst profil genet background antimicrobi resist three k pneumonia strain almost similar coloni insid outsid inhibit zone strain howev remark differ three strain blakpc blaoxa gene respons carbapenem resist e coli k pneumonia strain respect first studi demonstr similar genotyp resist gene profil resist suscept subpopul strain addit metabol transcriptom investig need understand mechan respons carbapenem heteroresist
|
D007710;D004927
|
T047
|
36,329,230
|
target delet ecto nucleotidas result retent inosin monophosph content postmortem muscl medaka oryzia latip inosin monophosph imp import indic meat fresh contribut umami tast attract strategi enhanc umami suppress imp degrad activ increas imp content skelet muscl genom edit technolog use crispr cas system howev molecular mechan under imp degrad remain unclear clone two ecto nucleotidas gene design ecto nucleotidas ntea ecto nucleotidas b nteb medaka oryzia latip vertebr model organ express analysi use embryo show ntea nteb overexpress remark upregul imp degrad imp degrad activ higher ntea nteb furthermor establish frame shift larg delet lack ntea nteb locus mutant strain assay effect gene disrupt amount imp skelet muscl ntea defici medaka show consider higher level imp h postmortem wild type fish nteb mutant also exhibit higher imp content wild type increas less ntea mutant result demonstr nte import regul imp level skelet muscl loss function effect maintain imp content
|
D007291;D009990
|
T123;T121;T114;T013
|
36,329,229
|
expans fibroblast cell sheet use modifi meek micrograft techniqu wound heal applic cell sheet engin scaffold free approach fabric function tissu construct sever cell monolay shown promis tissu regener wound heal unfortun cell sheet often small provid suffici wound area coverag studi describ process enlarg cell sheet use meek micrograft techniqu extens use expand skin autograft larg burn treatment human dermal fibroblast cell sheet place meek prefold gauz without use adhes cut along premark line stretch various expans ratio result regular distribut mani squar island fibroblast much larger surfac area cellular process essenti wound heal includ reattach prolifer migrat fibroblast expand meek gauz superior nylon dress serv control optim expans ratio highest migrat rate possibl due activ chemic signal caus mechan stretch effect intercellular communic distanc therefor combin cell sheet engin meek micrograft techniqu could provid high qualiti cell larg coverag area would particular benefici wound care applic
|
D016038;D002056
|
T061;T037
|
36,329,227
|
effect vitamin supplement cellular immun inflammatori marker covid patient admit icu vitamin immunomodul studi patient sever covid studi aim estim efficaci vitamin supplement cellular immun inflammatori marker patient covid admit intens care unit icu singl center doubl blind random placebo control pilot trial conduct n patient random assign receiv week oral dose iu vitamin follow daili mainten dose iu n placebo n primari outcom lymphocyt count natur killer nk natur killer nkt cell count neutrophil lymphocyt ratio nlr serum level inflammatori marker th day treatment day patient vitamin group display signific higher nk nkt cell count nlr placebo group mortal rate vs p need mechan ventil vs p incid nosocomi infect vs p signific differ group vitamin supplement compar placebo signific increas lymphocyt count translat reduc mortal icutri registr clinicaltrialsgov identifi nct
|
D002762;D000086382
|
T121;T067;T127;T109;T047
|
36,329,226
|
genet divers anti oxid potenti streptomyc spp isol unexplor nich meghalaya india streptomyc genet function divers genus known produc wide array phenol flavonoid signific biotechnolog applic isol belong speci streptomyc collect meghalaya india analyz genet divers use box pcr signific inter intra generic divers observ among streptomyc isol especi belong cacaoi lavendula olivochromogen aureus flavoviren bioactiv screen isol rectiviolaceus mjm record highest dpph activ wherea antimycoticus msca show excel abt radic scaveng activ hand novaecaesarea mjm highest g gae g fresh weight phenol content rectiviolaceus mjm record highest flavonoid content g qe g fresh weight compar total flavonoid content total phenol content stronger correl antioxid activ hplc analysi five select isol show presenc gallic acid pyrocatechol predomin phenol case flavonoid three isol show presenc rutin rochei msca highest rutin content g g fresh weight result studi show high genet divers antioxid potenti among streptomyc isol
|
D000975;D013302
|
T123;T121;T007;T039;T044
|
36,329,221
|
numer simul experiment research mechan behaviour hydraul disc brake base multi bodi dynam vital road construct machin bridg erect machin work complex environ brake import link maintain safeti stabil bridg erect machin serious consequ fail establish brake simul model specifi fault characterist accord actual oper status make effici find caus fault maintain safeti machin long time simul model brake bridg erect machin establish adam brake arm center axi obvious data characterist flexibl process finit element analys use abaqus verifi accuraci simul model rectangular rosett appli special geometr point strain data gather use dhn collector compar simul model adam kinemat simul model use simul actual oper condit experi disc spring two typic fault phenomena select reduc insuffici disc spring oil pressur two fault characterist extract variat brake shoe clearanc variat brake system pressur brake generat fault characterist normal oper brake affect fault characterist first stage fault characterist beyond critic threshold fault phenomena brake generat result simul experi prove method use simul model extract fault characterist brake system distinguish caus fault feasibl
|
D012775
|
T073
|
36,329,219
|
abnorm cortisol profil psychosoci stress among patient schizophrenia chines popul accumul evid suggest hypothalam pituitari adren axi dysfunct might play import role pathophysiolog schizophrenia aim studi explor cortisol respons psycholog stress patient schizophrenia studi patient schizophrenia n healthi volunt n ask complet psycholog stress challeng task includ pace auditori serial addit task mirror trace persist task pre post task saliva sampl collect measur cortisol level emot psychopatholog assess posit negat affect schedul posit negat syndrom scale result show cortisol respons negat emot patient schizophrenia differ signific healthi volunt signific interact sampl time diagnosi saliva cortisol level signific interact score time diagnosi negat affect score pana chang salivari cortisol level negat affect score psycholog stress challeng task correl clinic symptom patient schizophrenia find indic abnorm cortisol profil patient schizophrenia might biolog characterist diseas
|
D012559;D004700
|
T047;T048
|
36,329,213
|
impact probiot geotrichum candidum qaugc health product gut microbi divers dairi cattl gut microbi divers determin anim product health probiot supplement feed known modul gut microbi divers result better feed util resist diseas current studi design determin probiot potenti geotrichum candidum qaugc vhdp sahiw friesian crossbr dairi cow impact gut microbi divers health product evalu health product growth perform determin blood paramet serum biochemistri feed effici milk yield composit nutrient digest determin compar control experiment group moreov end experi gut microbi divers evalu miseq illumina sequenc bacteri fungalyeast dna dung sampl control experiment cow inspit signific reduct dri matter intak increas feed effici milk yield observ experiment cow normal hematolog serum biochem profil increas anaerob bacteri count decreas shred pathogen flora observ experiment cow metagenom analysi reveal proteobacteria firmicut actinobacteria bacteroidet four domin phyla among bacteria ascomycota follow basidiomycota neocallimastigomycota among fungal popul group divers core microbiom reveal high bacteri fungal alpha divers experiment group control via shannon index studi provid insight safe use g candidum probiot improv growth perform health product gut microbi divers dairi cattl
|
D000069196;D019936
|
T007;T001
|
36,329,210
|
atp bind hydrolysi human nlrp innat immun system use inflammasom protein recogn danger signal fight invad pathogen nlrp multidomain protein belong famili stand atpas character central nucleotid bind nacht domain incorpor atp thought correl larg conform chang nlrp lead activ state sensori protein analyz intrins atp hydrolysi activ recombin nlrp revers phase hplc wild type nlrp appear two differ conform state exhibit approxim fourteen fold differ hydrolysi activ accord inact autoinhibit state open activ state impact canon residu nucleotid bind site walker b motif sensor analyz site direct mutagenesi cellular experi show reduc nlrp hydrolysi activ correl higher asc speck inflamm stimul addit kinas nek chang hydrolysi activ nlrp data provid comprehens view function conserv residu nucleotid bind site nlrp correl atp hydrolysi inflammasom activ
|
D000071199;D058847
|
T123;T116
|
36,329,207
|
develop character vitro biolog perform amphotericin b terbinafin microemuls leishmania major studi evalu effect microemuls contain amphotericin b amb alon associ terbinafin tbf leishmania major l major use vitro model formul drug formul describ evalu cytotox ja macrophag potenc promastigot intracellular amastigot model evalu use vitro mtt assay giemsa stain respect base pseudo ternari phase diagram unload tbf load tbf amb load amb mean droplet size success prepar respect concern toxic amb tbf indic lower toxic ms compar free drug formul show consider inhibitori effect compar free drug form ic examin ic valu amb gml amb gml tbf gml tbf gml amb tbf gml amb tbf gml estim h respect
|
D000666;D018320
|
T195;T204;T109
|
36,329,205
|
preval risk factor potenti symptom hyponatremia spinal surgeri elder patient old age spinal surgeri signific increas risk postop hyponatremia howev detail analys postop hyponatremia spinal surgeri elder patient lack therefor retrospect review record consecut patient age year underw spinal surgeri evalu frequenc risk factor symptom postop hyponatremia spinal surgeri elder popul postop hyponatremia defin postop blood sodium level meql postop day pod pod andor pod total patient show postop hyponatremia multivari analysi diagnosi spinal tumorinfect decompress fusion surgeri lower preoper sodium level signific independ factor postop hyponatremia p respect total case could symptomat vomit note case nausea case headach case disturb conscious includ delirium ten case incid symptom signific higher elder patient postop hyponatremia match control group without postop hyponatremia p respect addit length stay day longer patient match control p
|
D007010
|
T047
|
36,329,204
|
antibiot use risk colorect neoplasia updat meta analysi accumul evid indic antibiot use could induc microbiom dysbiosi critic driver onset progress colorect cancer crc relationship antibiot use crc still disput henc conduct systemat review meta analysi apprais synthes present avail evid clarifi associ
|
D015179;D003110
|
T191
|
36,329,203
|
construct valid web base nomogram detect prognost prostat adenocarcinoma bone metastasi bone metastasi bm one common site metastasi prostat adenocarcinoma pa pa bm signific diminish patient qualiti life result poor prognosi object studi establish two web base nomogram estim risk prognosi bm pa patient surveil epidemiolog end result seer databas data patient diagnos pa retriev retrospect logist cox regress respect use determin independ risk prognost factor construct two web base nomogram result valid receiv oper characterist roc curv calibr curv decis curv analysi dca kaplan meier analys independ risk factor bm pa patient includ race psa isup stage n stage brain liver lung metastasi surgeri radiat chemotherapi independ prognost predictor overal surviv os age marit status psa isup liver metastasi nomogram could effect predict risk prognosi bm pa patient accord result roc curv calibr dca train valid set kaplan meier analysi illustr prognost nomogram could signific distinguish popul differ surviv risk success construct two web base nomogram predict incid bm prognosi pa patient bm may assist clinician optim establish individu treatment program enhanc patient prognos
|
D001859;D011471;D000230
|
T191
|
36,329,196
|
rosmarin acid prevent post oper abdomin adhes rat model studi aim determin effect rosmarin acid involv mechan decreas postop periton adhes format rat various incis remov cm piec peritoneum use induc periton adhes experiment group follow sham group control group periton adhes induc treatment perform treatment group follow induc periton adhes anim receiv rosmarin acid mgkg dosag respect macroscop examin adhes indic adhes band reduc treatment group compar control group moreov adhes score decreas treatment group day inflamm fibroblast prolifer reduc treatment group day tgf tnf vegf evalu western blot immunohistochemistri day treatment group reduc inflammatori cytokin day treatment group mgkg dosag decreas tgf tnf level treatment group administr rosmarin acid signific reduc mda increas cat level conclus rosmarin acid effect reduc adhes band inflammatori cytokin angiogenesi oxid stress
|
D053773;D014409
|
T129;T123;T121;T116
|
36,329,193
|
physic perform maximum tongu pressur associ oral intak independ retrospect studi hospit patient heart failur dysphagia patient heart failur lead poorer outcom hospit discharg therefor address dysphagia critic improv patient prognosi retrospect observ studi aim evalu associ improv swallow dysfunct time hospit discharg physic function cognit function nutrit status maximum tongu pressur mtp overal patient underw cardiac rehabilit deem oral intak impair includ exclus criteria compris follow pre admiss diagnosi dysphagia hospit death miss data patient categor base whether n n exhibit improv oral intak impair determin function oral intak scale foi score discharg associ potenti explanatori variabl foi score discharg assess use linear regress model adjust covari age sex heart failur sever short physic perform batteri score mini mental state examin score transthyretin level provis swallow therapi foi score discharg signific associ mtp p confid interv conclus mtp independ associ improv foi patient heart failur
|
D003680;D006333
|
T047;T046
|
36,329,190
|
januari june birth season across two centuri rural polish communiti season birth worldwid phenomenon mechan behind remain insuffici explor birth season like driven season chang women fecund ie abil conceiv strong influenc energet status test whether birth season driven high workload andor low access food use year birth data agricultur rural polish communiti first analys time seri birth within annual varianc birth proxi extent season second test hypothesi high agricultur workload andor low access food decreas number birth found season birth throughout year observ agricultur polish popul domin birth season januari februari gradual shift toward june late twentieth centuri observ pattern support hypothesi birth season result women energet status discuss possibl reason result support test hypothesi implic understand birth season
|
D001723;D036801
|
T081;T040
|
36,329,187
|
qualiti life associ factor among famili caregiv individu psychiatr ill drh south wollo ethiopia mental ill result enorm social econom burden patient also famili communiti mani caregiv patient mental ill suffer extrem poor qualiti life sub saharan africa approxim caregiv suffer econom burden sever mental ill knowledg studi conduct qualiti life caregiv ethiopia therefor studi aim assess qualiti life famili caregiv patient mental ill dessi referr hospit institut base cross section studi conduct among caregiv select use consecut sampl techniqu world health organ qualiti life bref use assess qualiti life logist regress perform statist signific declar p valu famili caregiv poor qualiti life divorc unabl read write primari educ spous sibl children patient poor social support high perceiv stigma signific associ outcom variabl magnitud poor qualiti life among famili caregiv high famili intervent program high recommend improv qualiti life among caregiv
|
D017028;D001523
|
T099;T098;T097;T048
|
36,329,185
|
methyltransferas domain dnmt essenti domain acut myeloid leukemia independ dnmta mutat aberr dna methyl pattern promin featur cancer methyl dna mediat dna methyltransferas dnmt protein famili regul de novo dnmta dnmtb mainten dnmt methyl mutat dnmta observ approxim acut myeloid leukemia aml hypothes dnmt dnmtb could function synthet lethal therapeut strategi dnmta mutant aml crispr cas tile screen perform identifi function domain within dnmtdnmtb exhibit greater depend dnmta mutant versus wild type cell line although increas sensit dnmt mutat observ dnmta mutant cellular model test subtleti result prevent us base conclus synthet lethal relationship dnmt dnmta data suggest therapeut window dnmt methyltransferas inhibit dnmta driven aml may exist valid biolog relev model requir
|
D008780;D015470
|
T191;T126;T116
|
36,329,181
|
protect insect neuron erythropoietincrlf mediat regul pro apoptot acetylcholinesteras cytokin receptor like factor crlf conserv larg uncharacter orphan cytokin receptor eumetazoan anim crlf mediat neuroprotect insect stimul human erythropoietin identifi mechan crlf mediat neuroprotect studi express proapoptot function acetylcholinesteras insect neuron expos primari brain neuron tribolium castaneum apoptogen stimuli dsrna interfer acetylcholinesteras gene express compar surviv acetylcholinesteras express presenc absenc crlf ligand erythropoietin hypoxia increas apoptot cell death express acetylcholinesteras code gene ace ace ace gene give rise singl transcript normal apoptogen condit pharmacolog inhibit acetylcholinesteras rnai mediat knockdown either ace ace express prevent hypoxia induc apoptosi activ crlf protect concentr erythropoietin prevent increas express acetylcholinesteras larger impact ace ace contrast high concentr erythropoietin caus neuron death induc ace express henc promot apoptosi studi confirm general proapoptot function ach assign role ace ace regul apoptot death identifi erythropoietincrlf mediat prevent enhanc acetylcholinesteras express apoptogen condit neuroprotect mechan
|
D000110;D004921
|
T125;T121;T126;T116
|
36,329,178
|
develop seam track devic asynchron tandem weld arc sens tandem weld extens use weld larg structur ship plant increas weld speed volum seam track essenti larg amount thermal deform howev tandem weld arc interfer caus current voltag vari non uniform lead difficulti seam track therefor studi optim signal identifi seam track tandem weld evalu select seam track signal algorithm develop separ weld signal peak averag base base collect data regress signal nois ratio analys perform identifi suitabl seam track signal trace weld line base select signal weld signal check weav v groov specimen result current area differ weld signal generat left right part center v groov could calcul algorithm equip seam track construct use area differ weld current final seam track system verifi conduct actual test use equip algorithm appli
|
D014896
|
T057
|
36,329,176
|
complex stream conscious typic conscious defin individu specif stream experi modern conscious research dynam function connect use cluster techniqu creat common base compar differ individu propos altern approach combin modern theori conscious insight aris phenomenolog dynam system theori approach enabl represent individu connect dynam intrins defin individu specif landscap given wealth evid relat function connect experienti state assum landscap proxi measur individu stream conscious investig properti landscap individu differ state conscious show conscious associ short term transit less predict quicker averag constant also show tempor specif connect state less easili describ network pattern distant time suggest richer space possibl state show cortex cerebellum subcortex display conscious relev dynam discuss implic result form point contact dynam system interpret phenomenolog
|
D003243;D001921
|
T023;T041
|
36,329,173
|
enhanc health novel sugar content genet engin sugarcan juic integr molecular character thsygii cemb sig enhanc sugar content yield health sugar product sugarcan demand high profil scientif strategi previous effort foster manipul metabol pathway trigger sugar product combat abiot stress fail yield high sugar recoveri saccharum officinarum l novel sucros isom trehalulos th isomaltulos im natur manufactur microbi sourc pursuanc novel scientif methodolog codon optim sucros isomeras gene trehalulos synthas gene ii cemb sig clone dual combin stem specif constitut promot pcambia express vector integr vacuol target signal peptid vts concentr gene product vacuol result mrna express obtain real time pcr valid extrem increas transgen express sugarcan culm leaf tissu overal sugar estim transgen sugarcan line execut refractomet hplc base quantif trehalulos th alongsid differ internod transgen sugarcan confirm enhanc boost sugar concentr matur sugarcan culm trehalulos synthas gene ii recept sugarcan line indic unpreced impress duli combin constitut stem regul promot transgen sugarcan line produc highest sugar recoveri percentag compar control line increas sugar recoveri percentag transgen sugarcan valid utmost perform express thsygii gene high profil liquid chromatographi base sugar content estim trehalulos th isomaltulos im yield unpreced improv whole sugar recoveri percentag compar control line
|
D031786
|
T002
|
36,329,170
|
associ pre gravid first trimest matern weight implic clinic research studi clinic research weight measur first trimest often treat surrog pre pregnanc weight valid critic assumpt howev uncertain thus sought prospect evalu relationship pre gravid weight first trimest weight prospect preconcept observ cohort studi newli marri women liuyang china underw pre gravid evalu median week singleton pregnanc weight measur first trimest relationship pre gravid first trimest weight assess bland altman analysi concord correl coeffici pearson correl mean pre gravid weight kg mean weight first trimest kg concord correl coeffici pre gravid first trimest weight limit agreement pearson correl r p indic good concord correl time weight measur first trimest increas week increment week week concord correl coeffici rang pearson correl rang p conclus observ concord pre gravid weight weight measur point first trimest provid measur valid widespread practic clinic research treat first trimest weight measur surrog matern weight pregnanc
|
D011261
|
T079
|
36,329,161
|
activ water manag bring possibl restor degrad lake dryland region case studi lop nur china protect restor degrad arid lake global urgent issu document potenti recoveri dri salt lake lop nur call sea death locat terminus largest inland basin china tarim river basin chang relationship surfac water climat paramet groundwat basin last year analyz use satellit remot sens land data assimil product find increas surfac water basin groundwat level lop nur began show obvious posit respons rate declin groundwat level slow argu balanc achiev region groundwat recharg evapotranspir lop nur ecosystem gradual recov studi show encourag case protect restor degrad lake dryland region around world
|
D060106;D060587
|
T081;T083;T070;T082
|
36,329,160
|
impact il latenc revers agent combin reactiv nk cell mediat suppress hiv reservoir inhibitor histon deacetylas hdaci major latenc revers agent lra candid shock kill strategi erad hiv reservoir infect patient poor achiev initi hdaci base trial subsequ studi highlight need effici approach combinatori immunostimul therapi studi combin il pan hdaci vorinostat romidepsin panobinostat class select hdaci entinostat without pkc agonist prostratin impact vitro reactiv nk cell mediat suppress latent hiv result show pan hdaci entinostat reduc nk cell viabil function yet combin il revert negat effect pan hdaci except panobinostat hdaci ineffect reactiv hiv cd cell model latenc pan hdaci suppress spontan il prostratin induc hiv releas il prostratin combin show maxim activ moreov panobinostat impair stat nf b activ il prostratin respect final use effector nk target latent infect cd cell equal expos drug combin found il mediat suppress hiv reactiv nk cell inhibit panobinostat data rais concern encourag therapeut applic il lra combin
|
D015497;D015658
|
T005;T047
|
36,329,159
|
precis gynecolog oncolog circul cell free dna epigenom analysi artifici intellig accur detect ovarian cancer ovarian cancer oc lethal gynecolog cancer due primarili asymptomat natur late stage diagnosi develop non invas marker urgent prioriti report accur detect epitheli oc use artifici intellig ai genom wide epigenet analysi circul cell free tumor dna cftdna prospect studi perform genom wide dna methyl profil cytosin cpg marker convent logist regress six ai platform use oc detect perform gene set enrich analysi gsea analysi elucid molecular pathogenesi oc total cpgs signific differenti methyl fdr p valu genom wide oc high oc diagnost accuraci achiev convent logist regress achiev area roc curv auc ci sensit specif multipl ai platform achiev high diagnost accuraci auc exampl deep learn dl ai auc sensit specif term oc pathogenesi gsea analysi identifi adipogenesi retinoblastoma gene cancer top perturb molecular pathway oc find epigenom dysregul molecular pathway previous link cancer add biolog plausibl result
|
D000073888;D010051
|
T123;T191;T114
|
36,329,158
|
antibiofilm properti bioactiv compound actinomycet foodborn fish pathogen natur bacteria form biofilm multi layer structur adher microbi popul solid surfac exopolysaccharid protein nucleic acid addit caus foodborn infect biofilm major problem aquacultur actinomycet extract previous demonstr antibiofilm activ multipl foodborn fish pathogen character extract need studi identifi chemic structur antibiofilm properti four extract determin genet similar isol known streptomyc isol found sever extract contain multipl antibiofilm compound antibiofilm activ extract stabl ph furthermor antibiofilm inhibit destruct activ isol stabl differ temperatur crude extract demonstr activ biofilm form foodborn fish pathogen surfac stainless steel coupon well polystyren common use industri equip use pcr rrna gene dna sequenc analysi four actinomycet isol found ac pm pm pm similar streptomyc biofilm structur analyz use scan electron microscopi coupl energi dispers spectrometri analysi coniin propylpiperidin activ fraction crude extract ac pm pm isol piperidin tetrahydro furanyl activ pm isol
|
D039903;D013302
|
T007
|
36,329,157
|
acut anxieti covid pandem associ higher level everyday altruism prior laboratori research suggest human may becom prosoci stress threaten situat unknown whether link prosoci defens general real life examin associ defens respons real world threat covid pandem everyday altruism four independ sampl n us resid recruit onlin differ timepoint self report measur perceiv covid threat defens emot eg stress anxieti everyday altruism collect operation defens emot inspir threat immin framework ecolog model human anim respond vari level threat found perceiv covid threat associ higher level everyday altruism assess self report altruism scale import robust associ experienc acut anxieti high physiolog arous pandem respons typic characterist higher perceiv threat immin propens engag everyday altruism non signific negat associ found less acut defens respons like stress find support real life relat defens altruist motiv human may modul perceiv threat immin
|
D000533;D000086382
|
T047;T067;T054
|
36,329,154
|
case studi real time internet thing system site specif potato crop manag el salhia area egypt site specif manag technolog consid natur variabl within field factor relat crop growth improv manag practic agricultur treatment vari field small product zone save resourc environ improv crop qualiti size sinc site specif decis far fourth industri revolut concept process autom work address improv process spatial variabl analysi thus support manag decis develop system entitl egypad base internet thing enabl technolog egypad autom data collect zone delin accord land suitabl evalu map generat paper address case studi potato crop specif area egypt el salhia eighti five site chosen main dataset model process differ stage crop growth three manag zone recogn select field base differenti land suitabl characterist repres total area respect structur screen servic egypad describ paper egypad offer servic includ manag zone delin use absolut virtual coordin land suitabl assess lsa data entri field real time well excel sheet save map suitabl format variabl rate applic real time histor data process central manag flexibl formul event relat action implement egypad verifi system dynam produc non contigu isoband repres specif rang paramet valu proper export use program smart machineri proven egypad support one land differ geometri area locat number node egypad compar tradit lsa method found produc similar manag zone
|
D011198;D000080487
|
T168;T170;T002
|
36,329,152
|
treml polymorph increas mrna blood leukocyt progress atherosclerosi treml member trigger receptor express myeloid cell famili associ risk atherosclerosi progress coronari arteri diseas acut coronari syndrom coronari arteri calcif herein relationship treml express polymorph rs rs evalu patient subclin atherosclerosi n heart failur post acut myocardi infarct mi n first time treml variant rs g rs c leukocyt mrna express analyz qrt pcr rs g allel associ treml express ci p patient carri rs c minor allel tccc genotyp like express treml without c allel ci p well higher level treml express ci p thus report first time treml associ earli stage atherosclerot plaqu format later stage mi conclus treml mrna express blood leukocyt influenc minor allel g c may regul differ atherosclerosi progress stage asymptomat atherosclerosi diseas post mi
|
D050197;D003324;D009203
|
T047;T046
|
36,329,151
|
synthesi character radiosynthesi fluorin avt pgp chemoresist imag marker p glycoprotein pgp studi atp bind cassett abc efflux transport contribut chemoresist tracer develop detect vivo status chemoresist use positron emiss tomographi pet imag studi synthes label avt fluorin f follow vitro vivo analysi tosyl avt precursor synthes character h nmr c nmr avt label f use nucleophil substitut method standard set qualiti control perform specif pgp test umg cell without inhibitor tariquidar biodistribut vivo stabil test small anim mice biodistribut data f avt extract pet ct imag breast cancer patient n precursor synthes yield puriti label yield evalu radio hplc cell bind assay show specif tracer pgp uptak increas twice block pgp receptor radiotrac show hepatoren excret pathway clearanc anim studi uptak higher liver lung spleen heart min decreas min patient distribut show similar uptak pattern observ small anim f avt character success high radiochem puriti yield vitro vivo studi prove specif pgp safe patient use
|
D000072078;D019008
|
T060;T038;T042
|
36,329,149
|
evalu qualiti care postpartum hemorrhag new quantit tool popul base studi develop new tool assess global qualiti care post partum hemorrhag pph lead prevent caus matern mortal worldwid identifi characterist matern unit associ inadequ pph manag secondari analysi epimom popul base studi conduct french matern unit women gave birth includ women sever pph first develop score quantifi qualiti care pph identifi characterist matern unit associ inadequ care defin score th percentil multi level logist regress adjust individu characterist score combin key compon care took account deliveri mode pph caus pph vagin deliveri risk inadequ care increas low versus high volum matern unit deliveriesyear aor deliveriesyear aor compar deliveriesyear privat versus public unit aor low versus high level care unit aor pph cesarean characterist associ increas risk inadequ care absenc onsit anesthesiologist aor result indic opportun improv greatest
|
D006473
|
T046
|
36,329,148
|
pseudokinas nrp facilit endocytosi transferrin african trypanosom trypanosoma brucei caus human african trypanosomiasi hat nagana cattl infect vertebr endocytosi host transferrin tf import viabil parasit major protein involv trypanosom endocytosi tf unknown identifi pseudokinas nrp tbtmp regul tf endocytosi genet knockdown nrp inhibit endocytosi tf without block uptak bovin serum albumin bind tf flagellar pocket affect knockdown nrp howev quantiti tf per endosom drop signific consist nrp promot robust captur andor retent tf vesicl nrp involv motil tf laden vesicl sinc distanc endosom kinetoplast reduc knockdown gene search possibl mediat nrp modul tf endocytosi gene knock phosphoproteom analyz phosphoryl protein kinas forkhead nek mapk alter addit epsinr synaptobrevin vesicl associ protein predict involv endocytosi candid protein may link nrp function either protein kinas vesicl associ protein
|
D014345;D014346;D014353
|
T047;T204
|
36,329,147
|
zebra stripe repel bite fli close rang best support hypothesi zebra stripe stripe repel bite fli effect well establish mechan behind remain elus myriad hypothes suggest experi help narrow field possibl explan addit complex visual featur real zebra pelag natur rang stripe width larg left experiment design pair choic field experi kenyan savannah found hungri stomoxi fli releas enclosur strong prefer land uniform tan impala pelt stripe zebra pelt exhibit prefer pelt zebra speci widest stripe narrowest stripe find confirm zebra stripe repel bite fli naturalist condit close rang suggest sever mechan hypothes oper distanc unnecessari fli repuls effect indic interspecif variat stripe width associ select pressur bite fli
|
D007299;D004175
|
T204;T037
|
36,329,138
|
sar cov spike open dynam energet reveal individu role glycan collect impact trimer spike glycoprotein protrud sar cov viral envelop bind human ace initi least one protom receptor bind domain rbd switch close open state use larg scale molecular dynam simul two dimension replica exchang umbrella sampl calcul thousand window aggreg total simul investig transit without glycan find glycosyl spike higher barrier open also energet favor state state analysi protein open pathway reveal glycan n n interfer hydrogen bond rbd n termin domain state glycan n n stabil state final estim epitop exposur sever known antibodi chang along open path find bd antibodi epitop continu expos explain high efficaci
|
D000086402;D000086382
|
T005;T067;T047
|
36,329,137
|
short term memori trace persist day mous hippocampus activ recal short term memori stm known last hour whether stm long term function unknown show stm optogenet retriev time point natur recal possibl uncov long term exist stm engram moreov train within day led natur long term recal indic facilit consolid inhibit offlin ca activ non rapid eye movement nrem sleep n methyl aspart receptor nmdar activ protein synthesi first exposur stm form event impair futur exposur facilit consolid highlight role protein synthesi nmdar nrem sleep long term storag stm trace result provid evid stm complet lost within hour demonstr possibl two step stm consolid first long term storag behavior inact engram transform activ state recurr within day
|
D008570;D000069077
|
T041
|
36,329,136
|
conspiratori think precursor opposit covid vaccin us multi year studi despit widespread avail safe effect covid vaccin us elig us popul taken recommend initi dose covid vaccin april explan hesit focus misinform vaccin lack trust health author accept conspiraci theori pandem test whether conspiratori mindset distrust wide rang institut pois reject covid vaccin pandem even began answer question reinterview member nation us panel previous survey begin hypothes conspiratori mindset predict covid vaccin hesit better prior trust health author accept vaccin misinform mindset also like consum media bolster belief pandem conspiraci research need determin conspiratori mindset way minim likelihood consequenti health decis influenc
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,329,131
|
influenc nutrit status facial morpholog young japanes women evid regard possibl influenc nutrit status facial morpholog thus far insuffici examin whether physic bodi composit dietari behavior correl morpholog characterist face one hundr fifteen young japanes women particip variabl repres dietari behavior extract self report survey data correspond three dimension facial imag bodi composit examin multivari analys identifi signific relationship nutrit status facial topographi p cluster method reveal exist three dietari condit pattern balanc diet high calori diet obes tendenc imbalanc low calori diet sarcopen obes tendenc among three pattern round face increas facial width analysi varianc anova p observ high calori diet pattern imbalanc low calori diet pattern show masculin face increas face height decreas eye height increas non allometr sexual shape differ anova p thus suggest possibl sex hormon influenc summari bodi composit dietari behavior found influenc facial morpholog potenti biolog influenc discuss
|
D005145;D009752
|
T033;T029
|
36,329,129
|
simpl stochast model describ evolut genom gc content asexu reproduc organ genom nucleotid composit usual summar g uanin c ytosin gc denin hymin frequenc gc genom atgc content link environ select process asexu reproduc organ model present relat evolut genom gc content time formula see text gc gc formula see text mutat rate employ calculus shown mutat rate subject random perturb vari time sever implic follow particular extra brownian motion term appear influenc genom nucleotid variabl greater random perturb genom nucleotid variabl sever interpret depend context instanc reduc influenc random perturb atgc mutat rate thus genom nucleotid variabl limit fit decreas deleteri mutat like suggest channel resourc hand increas genom nucleotid divers may benefici variabl environ asexu reproduc organ brownian motion term consid invers reflect select pressur organ subject molecular level present model general previous model limit microbi symbiont asexu reproduc non recombin organ last connect present model classic luria delbrck mutat model present calculus set
|
D016678;D002137
|
T028;T031
|
36,329,128
|
cost effect scar manag post burn trial base econom evalu three intervent model optim burn scar manag potenti mark improv live children requir substanti healthcar resourc studi aim examin cost effect three scar manag intervent pressur garment topic silicon gel combin pressur garment topic silicon gel therapi alongsid randomis control trial intervent particip children n refer burn scar manag follow graft spontan heal acut burn injuri reconstruct surgeri healthcar resourc use cost health servic perspect month post burn time horizon mean total scar manag cost lowest topic silicon gel group ci compar pressur garment ci combin intervent group signific group differ qualiti adjust life year estim probabl topic silicon gel domin pressur garment therapi cheaper effect probabl pressur garment therapi domin combin therapi probabl topic silicon gel domin combin therapi conclus topic silicon gel cheaper intervent may favour absenc clear clinic effect favour pressur garment therapi combin manag approachestri registr actrn prospect regist
|
D020034;D017439
|
T122;T020;T109
|
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