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36,325,771
practic palliat care consult propos emerg depart peke union medic colleg hospit object summar palliat care consult propos emerg depart peke union medic colleg hospit method retrospect studi conduct palliat care consult emerg depart peke union medic colleg hospit januari june result total patient male femal receiv palliat care consult emerg depart averag age year year specif patient receiv twice consult respect patient complet consultationof patient receiv palliat care consult malign tumor non neoplast diseasesth reason palliat care consult includ communic pain relief term place death patient die hospit patient medic institut conclus clear demand palliat care consult emerg depart peke union medic colleg hospit consult bring help emerg doctor patient
D010166;D012017
T061;T058;T170;T097
36,325,770
experi communiti base home hospic care practic patient beij puhuangyu communiti object investig feasibl home hospic care base practic experi puhuangyu communiti beijingmethod select patient assess hospic care team receiv home hospic care puhuangyu communiti health servic center beij januari decemb clinic manifest hospic servic receiv place death patient analyz result total patient includ studythey main suffer malign tumor patient pain common symptom patient patient receiv varieti hospic servic combin outpati visit home visit wechat follow upth servic time patient h week averag patient pass away home conclus home hospic care puhuangyu communiti stabl sourc patientsth member hospic team provid varieti home hospic serviceswith model wish pass away home achiev patientstherefor model communiti base home hospic care feasibl
D017051;D006738;D006699
T058;T073;T093
36,325,769
obstacl practic palliat care consult servic grade tertiari hospit object explor obstacl palliat care consult servic put forward suggest improv servic grade tertiari hospit method semi structur interview conduct medic worker request palliat care consult servic peke union medic colleg hospit result palliat care consult servic hinder five obstacl factor includ insuffici knowledg patient famili palliat care unsound understand medic worker palliat care poor implement consult opinion limit labor palliat care team poor econom benefit palliat carein view obstacl follow suggest put forward includ increas accept palliat care patient famili enrich knowledg medic staff palliat care establish new cooper model consult team medic staff strengthen institut guarante develop palliat care establish perfect law polici relat palliat care conclus although mani difficulti hospit palliat care consult servic grade tertiari hospit demand expect medic staff palliat care still increas
D010166;D012017
T061;T058;T170;T097
36,325,768
communiti base home hospic care model guidanc tertiari hospit communiti base home hospic care provid communiti servic center famili physician team aim allevi suffer termin ill patient help receiv end life care pass away hometh puhuangyu communiti health servic center establish home hospic care model pumch puhuangyu coordin end model practic improv datethi paper introduc model home hospic care
D017051;D006738;D006699;D013727
T058;T073;T093
36,325,767
establish hospic palliat care train platform volunt let general public regardless gender age career educ background understand core concept hospic palliat care practic live spread serv mani peopl possibl hospic palliat care team peke union medic colleg hospit establish profession hospic palliat care train platform volunt articl review train design content method result platformit conclud platform theori base train design logic complet train content suitabl train method volunt satisfactori train resultsth establish hospic palliat care train platform volunt excel feasibilityeffort made explor perform long term develop strategi train platform
D006738;D017051
T058;T073;T093
36,325,766
assess posterolater lumbar fusion systemat review imag base fusion criteria noninvas assess osseous fusion spinal fusion surgeri essenti time diagnosi patient symptomat pseudarthrosi evalu perform spinal fusion procedur howev consensus definit assess success posterolater fusion plf lumbar spine systemat review aim summar criteria use imag base fusion assess instrument plf evalu diagnost accuraci reliabl
D013123;D013122
T061;T047
36,325,711
synchron hairi cell leukemia hepatocellular carcinoma case report multipl primari malign tumor character independ occurr develop two malign neoplasm patient present extrem rare case synchron doubl primari malign hairi cell leukemia hepatocellular carcinoma lethal outcom diagnosi hepatocellular carcinoma difficult due presenc lymphoprolif diseas complic visual process use ultrasonographi carcinomat emboli hepatocellular carcinoma small pulmonari arteri without format metastat foci led clinic manifest typic pulmonari embol pulmonari hypertens sever respiratori failur lymphoprolif diseas necessari take account possibl develop anoth malign neoplasm buri tumor infiltr
D006528;D008113;D007943;D009378
T191
36,325,710
profil cd express bone marrow cell patient acut myeloid leukemia acut myeloid leukemia aml high heterogen diseas accompani arrest myeloid cell lineag differenti ation due accumul genet abnorm clonal prolifer myeloid blast find differenti express molecul studi function within aml subgroup may help improv diagnosi prognosi aim develop select therapi aml subset aim studi reveal profil cd cell surfac express bone marrow bm cell aml patient
D015473;D015470
T191
36,325,709
treatment option fertil spare radic trachelectomi neoadjuv chemotherapi patient cervic cancer tumor size cm radic trachelectomi combin pelvic lymphadenectomi plnd use treat earli stage cervic cancer patient wish preserv fertil vagin abdomin laparoscop robot approach use radic trachelectomi pelvic plnd caus periton damag could result periadnex adhes propos neoadjuv platinum base chemotherapi nact vagin radic trachelectomi retroperiton plnd fertil preserv option earli stage cervic cancer patient vrt retroperiton plnd perform three women figo stage ib iia cervic cancer three patient complet respons achiev without caus intraop sever postop complic nact fertil spare treatment innov approach potenti quit interest mani young women affect cervic cancer tumor size cm vagin radic trachelectomi retroperiton plnd safe perform periton damag caus periadnex adhes could avoid consid surgic approach nact may good treatment option women cervic cancer wish preserv fertil
D000069339;D002583
T061;T191
36,325,708
prognost role residu tumor featur negat breast cancer aim studi examin prognost valu immunobiolog marker tumor infiltr lymphocyt til subpopul residu tumor neoadjuv chemotherapi nact complet patient tripl negat tnbc lumin b neu negat breast cancer lbbc
D001943;D064726
T191
36,325,707
ovarian toxic fac chemotherapi rat possibl correct platelet rich plasma compar dynam chang hormon status femal rat set fac fluorouracil doxorubicin cyclophosphamid chemotherapi local administr platelet rich plasma prp
D054304;D053657
T125;T121;T116;T031
36,325,706
express immunoglobulin sequenc homolog anti sar cov antibodi hiv chronic lymphocyt leukemia case identif epitop recogn leukem b cell could provid insight molecular mechan b cell transform chronic lymphocyt leukemia cll aim paper compar nucleotid sequenc immunoglobulin heavi chain variabl region ighv gene cll known sequenc direct antigen differ origin avail public databas
D015451;D000086382;D015658
T047;T191;T067
36,325,705
antiprolif activ extract myceli biomass medicin basidiomycet human colon cancer cell colo anticanc effect phytohormon cytokinin natur similar medicin mushroom abl synthes cytokinin larg amount
D000230;D003110
T191
36,325,704
effect dextran graft polyacrylamidezno nanoparticl prostat cancer cell line vitro combin zinc oxid zno nanoparticl nps carrier enhanc anticanc effect nanocomposit
D015034;D011471;D053768
T121;T197;T191;T073
36,325,703
featur oxid metabol genet disord peripher blood lymphocyt patient primari cervic cancer combin chemo radiotherapi use main treatment local advanc cervic cancer cc may lead side effect healthi cell undermin effect treatment qualiti life assess damag level healthi radiosensit cell tumor environ treatment import order predict prevent remot side effect radiat
D002583
T191
36,325,702
overview discuss decis make total neoadjuv therapi distal rectal cancer advanc implement complex treatment distal rectal cancer led decreas number loco region recurr high rate distant metastas remain lead disappoint long term oncolog result requir search improv stage complex treatment consequ question effect adjuv polychemotherapi distal rectal cancer question possibl transfer drug treatment adjuv neoadjuv regimen reason rais present option full neoadjuv therapi develop test lead oncolog center base nation comprehens cancer network version recommend prematur make categor conclus regard recommend one anoth variant implement preliminari clinic result confirm need addit stage restag second option week polychemotherapi chemoradi order exclud general diseas therefor need prospect control intercentr studi answer unresolv question
D020360;D012004
T061;T191
36,325,701
valid panel biomark associ aggress phenotyp endometrioid carcinoma endometrium evalu prognost signific panel biomark identif high malign molecular subtyp endometrioid carcinoma endometrium ece
D018269
T191
36,325,700
role radioprotector minim stochast effect radiat incid real threat emerg situat ukrain dictat need take account experi previous radiat accid signific part popul expos low dose radiat case clinic manifest irradi most absent danger stochast carcinogen effect remain therefor present strategi radiat protect popul aim revis choos effect low toxic anti radiat mean main criterion develop stochast consequ exposur radiat induc genom instabl promot carcinogenesi use radiomitig abl weaken harm effect ioniz radiat critic high radiosensit system human bodi promis research show radiomitig effect inosin cultur human lymphocyt genet level signific decreas frequenc gamma induc chromosom aberr result experiment justifi expedi use radiomitig condit emerg situat minim occurr develop stochast effect popul
D011839;D002869
T049;T070
36,325,698
cytolog histopatholog correl studi neoplast lesion milan system report salivari gland cytopatholog salivari gland tumor rare nevertheless accur preoper diagnosi malign potenti lesion essenti appropri patient manag recent publish milan system report salivari gland cytolog msrsgc effort provid better communic regard natur lesion clinician aim evalu diagnost util fine needl aspir cytolog fnac neoplast salivari gland lesion msrsgc applic risk stratif
D012469;D012468
T023;T191
36,325,697
efficaci autolog stem cell transplant adult burkittburkitt like lymphoma systemat review burkitt burkitt like lymphoma blbll high prolif germin post germin b cell tumor studi evalu impact autolog stem cell transplant asct diseas outcom
D018380;D002051
T061;T191
36,325,696
express alpha smooth muscl actin odontogen cyst tumor odontogen cyst tumor exhibit differ degre aggress biolog behavior evid presenc myofibroblast mfs invas front promot tumor invas studi base fact mfs import biolog behavior odontogen cyst tumor
D000564;D009807;D009808;D011842
T047;T191;T190
36,325,674
lupus anticoagul hypoprothrombinemia syndrom sever bleed diathesi coronavirus diseas case report acquir antibodi factor ii prothrombin rare common associ sever liver diseas vitamin k antagonist treatment rare case antibodi associ hypoprothrombinemia found patient lupus anticoagul lac antiphospholipid antibodi inhibit phospholipid depend coagul test uncommon entiti call lupus anticoagul hypoprothrombinemia syndrom lahp may caus sever life threaten bleed predisposit thrombosi coronavirus diseas covid associ varieti coagul abnorm increas risk thrombosi bleed may occur less common thromboembol most describ associ sever diseas anticoagul treatment hospit patient rare post acut phase diseas report case year old man develop lahp prothrombin antibodi sever bleed covid
D007020;D000086382;D016736
T047;T067
36,325,673
preval burnout among health care worker feder bosnia herzegovina coronavirus diseas pandem cross section studi investig preval burnout syndrom among health care worker feder bosnia herzegovina fbih coronavirus diseas covid pandem
D000086382;D002055;D017934
T047;T005;T067;T048
36,325,672
detect measl virus bulgaria determin circul pattern measl virus bulgaria larg measl outbreak countri
D008459;D008457
T005;T047
36,325,671
ornidazol suppress cd melanoma stem cell via inhibit hedgehog signal pathway induc multipl death pathway mous model evalu inhibitori effect ornidazol prolifer migrat metastat melanoma cell line bf vitro anti cancer effect vivo use melanoma mous model
D008545;D009950
T121;T191;T109
36,325,670
prognost relev autophagi relat marker p lc beclin ovarian cancer analyz express autophagi marker p lc beclin ovarian cancer tissu evalu prognost potenti marker
D010051
T191
36,325,669
clinic characterist laboratori paramet deep venous thrombosi sar cov infect non hospit set singl center retrospect studi assess differ clinic laboratori paramet non hospit patient deep venous thrombosi dvt accord sar cov status
D000086382;D020246
T047;T046;T067
36,325,668
nocturn visual hallucin patient disord arous novel behavior eeg pattern investig clinic video polysomnographi vpsg find hallucinatori experi patient suffer disord arous doa absenc patholog
D004569;D001143
T060;T034;T041
36,325,667
croatian studi covid posit stroke patient second wave pandem investig stroke characterist patient concomit coronavirus diseas covid infect croatia second wave covid pandem
D000086382;D020521;D000083242
T047;T067
36,325,666
propens score match comparison minim invas convent aortic valv replac evalu impact minim invas aortic valv replac mini avr clinic outcom comparison gold standard
D001021;D019918
T061;T023
36,325,665
associ fear covid depress anxieti psychosi among lebanes chronic patient schizophrenia moder effect spiritu assess whether fear coronavirus diseas covid associ depress anxieti psychosi evalu variabl correl interact spiritu fear covid
D012559;D000086382;D011618
T047;T067;T048
36,325,643
multipl hyperplast colon polyp cow report bovin colon polyp rare present report demonstr macro microscop hyperplast colon polyp seven year old german simment cow differenti diagnos adenoma adenocarcinoma aetiolog discuss even cattl intestin polyp consid caus intussuscept
D003111;D000236;D000230;D002418
T047;T191;T190
36,325,642
radiat therapi treatment macroscop canin anal gland tumor retrospect studi canin anal gland tumor local invas earli metastas loco region pelvic lymph node radiat therapi good method loco region tumor control especi inoper tumor sinc organ pelvic area sensit acut late radiat damag chronic diarrhea bleed strictur intestin perfor damag main depend fraction size examin radiat protocol use studi reduc number fraction hypofraction regard effect side effect retrospect studi describ dog macroscop anal gland carcinoma irradi imag guid intens modul radiat therapi hypofraction curat protocol gy gross patholog either region anal gland andor sublumbar lymph node ten dog advanc tumor diseas stage b acut radiat reaction mild moder report dog previous studi mean studi time day rang day diseas progress observ suspect dog studi period local loco region progress occur dog distant metastas dog median progress free surviv day ci median surviv day ci one year treatment ci dog still aliv likelihood tumor progress lower increas age otherwis none examin tumor patient factor show prognost influenc progress surviv time clinic relev late side effect observ apart slight alopecia pigment chang dri scali skin medium long term tumor control expect dog macroscop anal gland tumor treat moder hypofraction radiat therapi protocol gy long term monitor serious side effect side effect requir treatment observ
D000694;D004283;D009369
T047;T191
36,325,641
glyphos detect duoden fluid hors gastric ulcer syndrom hay produc plant concentr straw meadow could contamin aerosol glyphos base herbicid spray process crop pre harvest desicc treatment cereal aim studi investig concentr glyphos duoden fluid hors gastric ulcer syndrom stomach duodenum refer untreat hors patient n colic weight loss diarrhoea anemia perform intoler endoscop examin right admiss duoden fluid ml collect duoden region papilla duodeni major locat hematolog clinic chemistri data examin concentr glyphos serum duoden fluid sampl analys use competit elisa control analysi also done hplc statist differ group determin non parametr mann whitney test use signific level p glyphos detect duoden fluid median ngml st quartil ngml rd quartil ngml min ngml max ngml blood sampl ngml ngml ngml ngml ngml hors glyphos concentr duoden fluid sampl signific higher blood sampl mann whitney u test p concentr glyphos duoden fluid signific higher hors squamous gastric diseas grade n compar hors normal squamous mucosa grade n median ngml versus ngml hors glandular gastric diseas grade n higher concentr glyphos duoden fluid hors normal glandular mucosa grade n median versus gamma glutamyltransferas ggt enzym activ signific higher group hors lower concentr glyphos duoden fluid ngml compar group higher concentr glyphos ngml median versus ul autumn hors higher concentr glyphos duoden fluid n median compar lower concentr spring time n median ngml hors kept around big citi signific higher concentr glyphos duoden fluid comparison hors live countrysid median ngml versus ngml
D013276;D006734;D002294
T047;T191
36,325,640
heart rate faecal cortisol metabolit measur hors sechseluten zurich zurich sechseluten tradit festiv zurich guild around hors take part parad old town zurich rider gather big squar canter around burn woodpil top explod effigi bgg level stress experienc hors partak event subject increas scrutini aim studi evalu stress load hors particip sechseluten process object measur heart rate faecal cortisol metabolit twenti three hors rider pair voluntarili recruit guild particip studi comparison purpos three section process simul term gait distanc travel normal ride environ test day observ sechseluten day later counter march bahnhofstrass parad limmatquai parad around burn bgg hors equip heart rate measur system gps track polar team pro polar electro oy finland faecal sampl measur cortisol metabolit taken rectal immedi hour event thirteen hors sedat sechseluten acepromazin mgkg po differ observ period group sedatedunsed test analysi varianc p
D006854;D005684
T125;T121;T033;T109
36,325,629
sex specif flower resourc use hummingbird communiti research highlight maglianesi maruyama p k temel e j schleun zanata b sazima gutirrez zamora marn gmez h rosero lasprilla l ramrez burbano b ruffini e salamanca rey j r sazima nuez rosa l e arizmendi c rahbek c dalsgaard b behaviour morpholog trait influenc sex specif floral resourc use hummingbird across america journal anim ecolog https doiorg paper intersexu differ nich breadth nich overlap floral resourc use hummingbird communiti maglianesi et al compil data plant hummingbird interact base pollen load territori morpholog trait hummingbird speci investig whether pattern resourc use femal male relat sexual dimorph forag behaviour account evolutionari related among speci author found high level resourc partit sex broader dissimilar floral nich breadth femal sex specif resourc use hummingbird speci relat territori morpholog trait nich overlap sex greater territori non territori speci lower speci greater sexual dimorph bill curvatur paper address two time issu one hand resourc partit sex reduc intersexu competit hummingbird hand highlight much need inform forag ecolog femal hummingbird better understand intersexu variat shape coexist speci divers hummingbird communiti interact plant hummingbird pollin
D001717;D035264
T002;T012
36,325,627
effect platelet activ differ agonist fibrin format thrombin generat activ platelet possess procoagul activ express surfac phosphatidylserin ps substrat assembl coagul complex examin effect platelet activ differ agonist fibrin format thrombin generat compar effect ps express modifi plasma recalcif assay develop assess platelet effect fibrin format wash human platelet left intact activ ionophor collagen arachidon acid adp trap thrombin receptor activ peptid spun well plate plasma ad recalcifi fibrin format monitor light absorb platelet prepar way test effect thrombin generat ps express evalu flow cytometri use annexin v stain platelet signific acceler fibrin format thrombin generat shorten lag phase increas maximum rate plasma clot increas peak maximum rate thrombin generat test platelet presum activ endogen thrombin form plasma trigger coagul reaction howev pretreat exogen agonist addit increas platelet procoagul activ reach maximum incub lower collagen arachidon acid minimum adp trap latter might ineffect due competit endogen thrombin effect platelet activ differ agonist fibrin format thrombin generat correl correspond ps express surfac
D013917;D001792
T121;T126;T116;T025
36,325,610
covid vaccin induc ventricular fibril afebril patient brugada syndrom year old man present cardiac arrest day second coronavirus diseas covid vaccin mrna vaccin electrocardiogram show ventricular fibril type brugada pattern st segment elev patient report symptom includ febril sensat known under cardiac diseas explain electrocardiograph abnorm st segment elev complet disappear two week although genet mutat person famili histori typic brugada syndrom flecainid administr induc type brugada pattern st segment elev case suggest covid vaccin may induc cardiac ion channel dysfunct caus life threaten ventricular arrhythmia specif patient brugada syndrom
D053840;D000086382
T033;T047;T067
36,325,609
comparison factor associ direct versus transfer admiss govern design region center acut ischem stroke myocardi infarct korea comparison determin admiss rout acut ischem stroke ai acut myocardi infarct ami examin whether factor associ direct versus transfer admiss region cardiocerebrovascular center rcvcs differ ai ami
D000083242;D009203;D020521;D004632
T061;T047;T058;T093
36,325,608
birth rate transit republ korea trend prospect korea birth rate declin alarm pace studi aim investig chang trend popul count number birth birth rate korea past futur
D001723;D003906
T081;T080
36,325,607
sar cov nave korean children adolesc hospit covid risk sever outcom sever acut respiratori syndrom coronavirus sar cov delta variant remain low children adolesc less known effect sar cov nave popul studi evalu clinic manifest risk factor moder critic coronavirus diseas covid most sar cov nave children adolesc
D000086402;D000086382
T005;T067;T047
36,325,604
evalu store platelet shape chang use imag flow cytometri platelet routin store room temperatur day transfus store platelet qualiti tradit assess kunicki morpholog score method requir extens train experi high subject moreov number laboratori familiar techniqu decreas cold storag platelet recent regain interest potenti advantag reduc bacteri growth preserv function howev platelet expos cold temperatur chang uniform discoid spheric shape reduc morpholog score outcom spheroid versus discoid cool develop simpler unbias screen tool measur temperatur induc platelet shape chang use imag flow cytometri reduc two dimens sphere appear circular disc detect spectrum fusiform circular defin circular event transvers axi longitudin axi fusiform event longitudin axi use assay mous human platelet show temperatur time depend two dimension shape chang fusiform circular consist three dimension chang disc sphere method describ valuabl tool detect shape chang differ respons agonist temperatur help screen therapeut measur mitig cold induc storag lesion
D001792;D015925
T059;T025
36,325,603
extracellular vesicl deriv choroid plexus trigger differenti neural stem cell choroid plexus secret cerebrospin fluid csf compos electrolyt cytokin growth factor metabolit extracellular vesicl ev flow interconnect brain ventricl cours csf compon act signal affect exampl neural stem cell nscs resid nich ventricular wall studi ev born csf signal vitro cultur system purifi ev secretom choroid plexus cell line z cell primari choroid plexus cultur co cultur ev nscs isol nich later third ventricl evsz evschp purifi differenti centrifug yield fraction ev nm diamet induc complex multicellular network format nsc differenti type ev convert round nscs cell extend long process contact nearbi alik shape cell mass spectrometri show differenti induc evz enrich membran membran associ protein involv cell differenti membran traffick membran organ hypothes type ev z cargo caus chang stem cell morpholog lead multicellular network nich cell shape transit may repres initi step nsc differenti
D000067128;D058953
T026;T025
36,325,601
surgic wound enhanc pro tumor macrophag respons acceler tumor growth lung metastasi tripl negat breast cancer mous model approxim one third breast cancer mortal result metastat recurr initi success surgeri andor therapi although primari tumor remov wide accept benefici long suspect surgeri contribut acceler metastat recurr investig surgic wound impact tumor progress lung metastasi murin model tripl negat breast cancer tnbc ten week old femal mice inocul cell week either subject cm long cutan contralater incis wound control non wound week monitor week week mice surgic wound display signific acceler tumor growth observ earli week post wound confirm increas tumor volum tumor weight post mortem surgic wound increas metastasi lung detect ivi imag vivo ex vivo week expect wound mice display decreas apoptosi increas prolifer primari tumor lung flow cytometri reveal primari tumor wound mice exhibit increas tumor associ macrophag specif like macrophag import promot tumor develop mainten metastasi immunofluoresc stain gene express data confirm increas macrophag primari tumor lung wound mice data suggest surgic wound acceler tumor progress lung metastasi mous model tnbc like mediat least part increas macrophag
D064726;D008175
T191
36,325,600
signific nuclear egfr abcg express malign transform oral potenti malign disord purpos studi investig express nuclear egfr negfr stem cell marker abcg oral leukoplakia ol oral erythroplakia oe assess signific prognost biomark malign transform
D009062;D002294;D011230;D009059;D006258
T047;T191
36,325,599
three dimension exoscop assist singl stage tracheal resect three dimension k exoscop surgic tool recent introduc numer field otolaryngolog microvascular surgeri otolog laryngolog howev surgic field may also benefit technolog case singl stage tracheal resect plan aid k exoscop year old femal post tracheostomi tracheal stenosi high qualiti magnif surgic field obtain facilit skeleton laryngotrach axi exoscop provid greater involv surgeri allow interact among oper room personnel learner could access field view first surgeon well perceiv depth surgic field technolog exoscop repres valid applic open surgeri perform laryngotrach stenosi advantag enhanc train educ allow precis surgic dissect reduc risk iatrogen damag surround structur
D008866;D019635
T061
36,325,598
shape fst pharyngoplasti step step closur techniqu pharyngocutan fistula one common serious complic associ total laryngectomi numer studi tri evalu causat predispos factor associ complic data consider variabl still intern consensus incid rate vari consider studi report rate k video present shape four step techniqu fst close pharyng mucosa total laryngectomi step step manner sutur perform braid absorb mm c vicryl plus ethicon somervill nj usa record perform use karl storz k vitom exoscop karl storz se co kg tuttlingen germani describ techniqu high definit video show step tip author shape pharyngoplasti closur techniqu divid four step key stitch area refin stitch modifi connel sutur modifi purs string sutur shape fst closur techniqu prove effect reproduc method feel could prefer choic primari pharyngoplasti closur
D017577;D010608
T047;T190
36,325,592
dynam cerebr autoregul intact chronic kidney diseas chronic kidney diseas ckd patient experi elev risk cerebrovascular diseas one factor may contribut heighten risk impair dynam cerebr autoregul mechan cerebr vessel modul cerebr blood flow fluctuat arteri pressur hypothes dynam cerebr autoregul would impair ckd test hypothesi compar dynam cerebr autoregul ckd patient stage iii iv match control con without ckd fifteen patient ckd con particip perform minut bout repeat sit stand maneuv hz hz mean arteri pressur map via finger photoplethysmographi middl cerebr arteri blood veloc mcav via transcrani doppler ultrasound measur continu cerebr autoregul character perform transfer function analysi tfa map mcav relationship deriv coher phase gain normal gain ngain observ group differ tfa metric repeat sit stand maneuv hz maneuv coher ckd con phase radian ckd con gain cmsmmhg ckd con ngain mmhg ckd con p hz maneuv n ckd n con coher ckd con phase radian ckd con gain cmsmmhg ckd con ngain mmhg ckd con p contrari hypothesi dynam cerebr autoregul remain intact ckd stage iii iv find suggest mechan like contribut increas cerebrovascular diseas burden experienc popul futur work determin cerebrovascular regulatori mechan impair relat cerebrovascular diseas risk ckd
D002560;D051436
T033;T047;T042
36,325,589
advanc glycat end product modul electrophysiolog remodel right ventricular outflow tract cardiomyocyt novel target diabet relat ventricular arrhythmogenesi diabet mellitus associ cardiovascular diseas cardiac arrhythmia accumul advanc glycat end product close correl cardiovascular complic mitochondri dysfunct oxid stress evok prolif inflammatori fibrot reaction might impair cardiac electrophysiolog characterist increas incid cardiac arrhythmia studi examin mechan advanc glycat end product may contribut arrhythmogenesi right ventricular outflow tract uniqu arrhythmogen substrat whole cell patch clamp convent electrophysiolog studi fluoresc imag western blot confoc microscop use studi electr activ ca homeostasi signal isol right ventricular outflow tract myocyt without advanc glycat end product gml advanc glycat end product treat right ventricular outflow tract myocyt similar action potenti durat control exhibit lower l type ca current higher late sodium current transient outward current moreov advanc glycat end product treat right ventricular outflow tract myocyt intracellular na revers mode na ca exchang current intracellular mitochondri reactiv oxygen speci less intracellular ca transient sarcoplasm reticulum ca content upregul calcium homeostasi protein advanc glycat end product relat signal pathway protein conclus advanc glycat end product modul right ventricular outflow tract electrophysiolog characterist larger late sodium current intracellular na revers mode na ca exchang current disturb ca homeostasi increas oxid stress mediat activ advanc glycat end product signal pathway
D032383;D003920
T047;T025
36,325,586
human vitro neurocardiac cocultur ivncc assay develop evalu cardiac contractil modul two promin organ system nervous cardiovascular system intric connect maintain homeostasi mammal recent year shown tremend effort toward therapeut modul cardiac contractil electrophysiolog electr stimul neuron innerv cardiac ganglia regul often overlook develop vitro model cardiac devic like peripher nervous system play role clinic effect develop vitro neurocardiac cocultur ivncc model system studi cardiac neuron interplay use human induc pluripot stem cell hipsc technolog demonstr signific express coloc cardiac marker includ troponin actinin neuron marker peripherin neurocardiac cocultur assess function coupl cardiomyocyt neuron evalu nicotin induc adrenerg norepinephrin effect found beat rate signific increas ivncc compar monocultur alon develop platform use nonclin model assess cardiac medic devic deliv nonexcitatori electr puls heart absolut refractori period cardiac cycl cardiac contractil modul ccm therapi robust cocultur respons observ vcm v monophas ms puls durat pace vcm v phase amplitud biphas ms puls durat ccm observ ccm effect kinet pronounc cocultur compar cardiac monocultur support hypothesi part ccm mechan action attribut peripher nervous system stimul studi provid novel character ccm effect hipsc deriv neurocardiac cocultur innerv human heart model extend investig arrhythm mechan neurocardiac safeti toxic post chronic exposur materi drug medic devic present data acut ccm electr stimul effect function optim cocultur use commerci avail hipsc deriv cardiomyocyt neuron moreov studi provid vitro human heart model evalu neuron innerv cardiac ganglia regul contractil appli ccm puls paramet close resembl clinic set ivncc platform provid potenti tool investig aspect cardiac neurolog devic safeti perform
D057026;D006333
T047;T046;T025
36,325,585
muscarin receptor rat ovari involv follicular develop steroid secret acetylcholin ach may involv regul ovarian function previous system studi rat show week intraburs local deliveri ach esteras blocker huperzin increas intraovarian ach level chang ovarian follicular develop evidenc increas healthi antral follicl number corpora lutea well enhanc fertil character ovarian cholinerg system rat studi whether innerv may contribut intraovarian ach explor cellular distribut three muscarin receptor mrs analyz involv mrs ovarian steroidogenesi examin role ovarian follicular develop normal condit anim expos stress condit employ muscarin antagonist atropin denerv studi decreas ovarian norepinephrin ovarian ach affect evidenc local nonneuron sourc ach locat granulosa cell gcs especi larg antral follicl associ ovarian vascular system trace found ex vivo ovari organo typic incub show mr agonist carbachol modifi steroid product express steroid biosynthet enzym intraburs vivo applic atropin mr antagonist week howev increas atresia secondari follicl result support exist intraovarian cholinerg system rat ovari locat main follicular gcs involv steroid product rather via mrs exert trophic function regul follicular atresia
D010053;D005496
T023;T042
36,325,583
celecoxib impair primari human myoblast prolifer differenti independ cyclooxygenas inhibit use non steroid anti inflammatori drug nsaid treatment musculoskelet injuri commonplac general athlet militari popul nsaid studi varieti tissu effect nsaid skelet muscl fulli defin address investig degre cyclooxygenas cox select nsaid celecoxib affect muscl cell prolifer differenti anabol signal mitochondri function primari human skelet myoblast myotub primari muscl cell treat celecoxib ns pharmacolog inhibitor cox control celecoxib administr signific reduc myoblast prolifer viabil fusion myotub area dose depend manner wherea ns effect outcom celecoxib treatment also associ reduc phosphoryl ribosom protein myoblast reduc phosphoryl akt psk erk myotub contrast ns alter phosphoryl molecul myoblast myotub myoblast celecoxib signific reduc mitochondri membran potenti respir evidenc decreas citric acid cycl cac intermedi cis aconit acid alpha keto glutar acid succin acid malic acid similar result observ myotub although celecoxib also reduc pyruv acid citric acid fumar acid ns affect cac intermedi myoblast myotub togeth data reveal celecoxib inhibit prolifer differenti intracellular signal mitochondri function primari human myoblast myotub independ function cox inhibitor
D052246;D032448
T121;T025;T109
36,325,582
high throughput genet screen meiotic commit use fluoresc microscopi saccharomyc cerevisia simpl genet screen bud yeast identifi mani conserv meiotic regul howev identif gene involv specif step meiosi may requir complex genet screen allow visual meiosi describ high throughput protocol use fluoresc microscopi systemat screen overexpress librari identifi gene involv meiotic commit also explain protocol adapt identifi protein function differ stage meiosi complet detail use execut protocol pleas refer gavad et al
D012441;D029701
T004;T116
36,325,581
protocol isol live singl cell retain spatial inform combin cell photolabel fac singl cell techniqu revolution biolog howev requir sampl process inher impli loss spatial local use approach call photoconvers area dissect micro environ padm detail step isol live singl cell primari breast tumor retain spatial inform combin cell photolabel fac fluoresc activ cell sort live cell subsequ use myriad techniqu flow cytometri singl cell rna sequenc singl cell omic approach complet detail use execut protocol pleas refer baldomino et al
D005434
T059
36,325,580
protocol genom edit wild allotetraploid rice oryza alta present protocol agrobacterium mediat genet transform genom edit wild allotetraploid rice oryza alta detail step induc embryogen calli matur seed co cultiv agrobacterium infect describ select transform cell prolifer infect calli base hygromycin resist result regener transform plantlet multipl edit allel edit line produc via protocol use gene function studi de novo domest alta complet detail use execut protocol pleas refer yu et al
D012275
T168;T002
36,325,579
protocol prepar phenanthrenequinon moieti rich carbon materi electrochem oxid electrocatalyt behavior carbon materi relat oxygen contain group type group determin activ carbon materi among phenanthrenequinon pq moieti function carbon materi critic speci catalysi field prepar pq moieti function carbon materi electrochem oxid provid synthesi detail pq group approach detect pq group perform evalu electrocatalyt oxygen evolut reaction oer acid condit complet detail use execut protocol pleas refer lu et al b
D002244;D010100
T121;T196;T123
36,325,499
compar analysi antioxid activ indigen produc moringa oleifera seed extract medicin plant use control remedi oxid stress relat diseas caus free radic thus plant find use remedi moringa oleifera extrem valu plant medicin properti herein two indigen produc access moringa oleifera seed origin multan mln india pkm investig antioxid properti diphenyl picrylhydrazyl dpph assay total phenol content total flavonoid content presenc various phenol well flavonoid confirm high perform liquid chromatographi moreov fourier transform infrar spectroscopi detect presenc various function group conclus find reveal methanol extract mln varieti seed show high antioxid potenti ic valu gml hexan extract pkm show least activ methanol extract mln found show highest total phenol content mg gaeg methanol extract mln found show highest total flavonoid content mg caeg hexan extract pkm found show least total flavonoid content mg caeg detect phenol ferul acid caffeic acid chlorogen acid coumar acid gallic acid well flavonoid catechin quercetin reveal potenti methanol extract varieti good sourc antioxid result indic import seed extract treatment oxid stress relat diseas futur use natur antioxid prevent progress diseas
D029588
T002
36,325,471
diagnost accuraci limit detect ten malaria parasit lactat dehydrogenas base rapid test plasmodium knowlesi p falciparum plasmodium knowlesi caus zoonot malaria across southeast asia first line diagnost microscopi reliabl differenti p knowlesi human malaria speci rapid diagnost test rdts design p falciparum p vivax use routin p knowlesi co endem area despit potenti cross reactiv speci specif antibodi target
D016790;D010271;D000962;D016778;D008288;D016780
T121;T047;T204
36,325,470
superior antivir activ ifn genit hsv infect type interferon ifn present first line defens viral infect provid antivir immunomodulatori antiprolif effect type ifn famili contain ifn subtyp ifn although share receptor classifi non redund capabl induc varieti differ ifn stimul gene howev biolog impact individu subtyp remain controversi recent data propos subtyp specif type ifn reveal uniqu effector function differ virus thus expand implic ifn base antivir immunotherapi despit extens research drug resist infect herp simplex virus type hsv common agent recurr orogenit lesion still lack protect cure therapeut howev due risk general infect immunocompromis host well increas incid resist convent antiherpet agent hsv infect rais major health concern base pleiotrop effector function applic type ifn repres promis approach inhibit hsv replic improv host immun elucid qualit differ select ifn subtyp ifn evalu therapeut potenti genit hsv infect respect vivo studi mice reveal subtyp specif differ reduct local viral load ifn strongest antivir efficaci genit hsv infect mice wherea ifn ifn ifn impact viral load base flow cytometr analys under immun respons local peripher site differ could assign specif modul antivir immun earli hsv infect ifn led enhanc system cytokin secret elev cytotox respons negat correl viral load vagin tract data provid insight divers type ifn effector function impact immunolog control hsv infect
D018259;D006558;D006561;D007370
T129;T121;T116;T005;T047
36,325,469
flavobacterium columnar ferric iron uptak system requir virul flavobacterium columnar caus columnari diseas one costliest pathogen freshwat fish farm industri virul mechan f columnar well understood current method control columnari outbreak inadequ iron essenti nutrient need metabol process often requir bacteri virul f columnar produc siderophor bind ferric iron transport cell gene need siderophor product identifi compon involv f columnar iron uptak studi detail identifi gene encod predict secret heme bind protein hmuy outer membran iron receptor fhua fhue feca compon atp bind cassett abc transport predict transport ferric iron across cytoplasm membran delet mutant construct examin growth defect iron limit condit virul zebrafish rainbow trout mutant delet gene encod outer membran receptor abc transport compon exhibit growth defect iron limit condit mutant lack multipl outer membran receptor abc transport hmuy retain virul zebrafish rainbow trout mirror exhibit wild type mutant predict defici multipl step iron uptak exhibit decreas virul survivor exposur mutant partial protect later infect wild type f columnar
D045826;D005393;D017686
T047;T013
36,325,468
non steroid anti inflammatori drug clinic outcom patient covid use non steroid anti inflammatori drug nsaid patient coronavirus diseas covid rais great concern effect nsaid clinic status covid remain question therefor perform post hoc analysi orchid trial patient covid orchid trial categor two group accord nsaid use day mortal hospit discharg safeti outcom nsaid patient covid analyz total hospit patient covid includ patient receiv nsaid patient took nsaid regular home medic patient took nsaid signific increas risk day mortal fulli adjust hazard ratio hr ci cox multivari analysi moreov nsaid decreas hospit discharg day fulli adjust hr ci result meta analysi includ studi involv patient covid show use nsaid surviv benefit summari risk ratio rr ci decreas risk sever covid summari rr ci conclus use nsaid associ wors clinic outcom includ day mortal hospit discharg american adult hospit patient covid base current evid use nsaid safe caution covid pandem ongo trial assess hospit treatment nsaid patient covid
D000086382
T047;T067
36,325,467
unravel mechan intrins drug resist mycobacterium tuberculosi tuberculosi tb among difficult infect treat requir sever month multidrug therapi produc durabl cure reason necessit long treatment time complex multifactori howev one major difficulti treat tb resist infect bacterium mycobacterium tuberculosi mtb mani distinct class antimicrobi review focus major gap understand intrins drug resist mtb function chemic genet help close gap better understand intrins drug resist help lay foundat strategi disarm circumv mechan develop potent antitubercular therapi
D009169;D014388
T047;T007
36,325,466
identif shewanella putrefacien novel pathogen largemouth bass micropterus salmoid histopatholog analysi diseas fish largemouth bass micropterus salmoid econom import aquacultur speci china product increas rapid recent year although shewanella putrefacien known infect sever fish speci role infect salmoid relat unknown isol gram negat bacteri strain term xx farm largemouth bass base result rrna sequenc phylogenet analys isol identifi putrefacien virul xx depend water temperatur ld valu cfug fish weight c c c respect four virul gene includ dksa hem lonr fur screen pcr assay result antibiot resist test show xx sensit kanamycin cefotaxim doxycyclin sulfamethoxazol florfenicol tetracyclin gentamicin show intermedi suscept streptomycin ampicillin norfloxacin resist nalidix acid penicillin xx infect fish show clinic symptom typic putrefacien infect addit isol xx infect fish confirm ident use rrna sequenc histopatholog chang observ intestin head kidney spleen liver diseas fish studi present first report pathogen effect putrefacien farm largemouth bass find may help develop effect diseas control strategi aquacultur fish prevent diseas outbreak low water temperatur
D001492;D020614;D005393
T047;T007;T013
36,325,465
interspeci relationship nosocomi pathogen associ preterm infant lactic acid bacteria dual speci biofilm nasogastr enter feed tube neft use feed preterm infant common colon bacteria abil form complex biofilm inner surfac among staphylococci main staphylococcus epidermidi staphylococcus aureus speci belong famili enterobacteriacea special concern sinc caus nosocomi infect popul netf associ biofilm also includ lactic acid bacteria lab abil compet pathogen speci nutrient space ecolog interact among main colon devic explor yet howev approach could guid futur strategi involv pre coat inner surfac neft well adapt lab strain order reduc rate nosocomi infect neonat intens care unit nicus context work impli format dual speci biofilm involv one lab strain either ligilactobacillus salivarius sng limosilactobacillus reuteri sng one nosocomi strain either klebsiella pneumonia sng serratia marcescen sng staphylococcus aureus sng staphylococcus epidermidi sng six strain use studi isol inner surfac neft chang adhes abil pathogen character use culturom approach speci interact structur chang result biofilm analyz use scan electron microscopi sem confoc laser scan microscopi clsm aggreg observ dual speci biofilm two lab strain either k pneumonia sng marcescen sng addit biofilm thick volum reduc suggest lab strain control capac form biofilm enterobacteria contrast posit ecolog relationship observ combin l reuteri sng aureus sng relationship accompani stimul aureus matrix product compar respect monospeci biofilm knowledg provid studi may guid select potenti probiot strain share nich nosocomi pathogen enabl establish healthier microbi communiti insid neft
D003428;D056546;D013203
T047;T007
36,325,463
clinic characterist prognosi patient leptospirosi multicent retrospect analysi south china leptospirosi zoonot diseas caus pathogen spirochet genus leptospira howev current consensu definit diagnost criteria sever differ form leptospirosi therefor insight clinic manifest risk factor outcom leptospirosi warrant identif leptospirosi distinct clinic manifest prognosi popul
D007922;D007919
T047;T007
36,325,462
genom comparison confirm giardia duodenali sub assemblag aii uniqu speci giardia duodenali parasit flagel protozoan infect wide rang mammalian host includ human subdivid least eight genet assemblag common thought repres cryptic speci molecular studi shown g duodenali assemblag parasit human anim contain sever phylogenet distinct group known sub assemblag molecular studi employ poor phylogenet resolut marker routin recov sub assemblag impli repres evolutionarili distinct clade possibl cryptic speci hypothesi support epidemiolog trend test hypothesi use avail data whole genom character sub assemblag coalesc techniqu statist estim speci boundari coupl function gene content analysi therebi assess stabil distinct clade analysi reveal two new sub assemblag clade well novel signatur gene content gear toward differenti host adapt popul structur via vertic inherit rather recombin panmixia formal propos sub assemblag aii new speci giardia homini preserv name giardia duodenali sub assemblag ai addit bioinformat method broad address challeng identifi cryptic microbi speci advanc understand emerg diseas epidemiolog broad applic lower eukaryot taxa interest giardia homini n sp zoobank lsid urn lsid zoobankorg pubf eef bdd ccce
D016829;D005873
T047;T204
36,325,460
preliminari experi elevis ir system detect parathyroid gland autofluoresc perfus assess icg postop hypoparathyroid remain frequent complic neck endocrin surgeri order reduc incid fear complic sever system imag near infrar autofluoresc niraf invent help surgeon identifi parathyroid gland ptgs evalu vascular evalu efficaci elevis ir system thyroid parathyroid surgeri
D010280;D007011
T023;T047
36,325,459
effect microvibr stimul development potenti discard germin vesicl oocyt human research aim studi effect continu microvibr stimul parthenogenet develop human germin vesicl oocyt
D012661;D009865
T025;T031
36,325,458
global research trend steroid induc osteonecrosi femor head year bibliometr analysi explor global research trend hotspot steroid induc osteonecrosi femor head sonfh qualit quantit analysi bibliometr
D005270;D047492
T023;T116;T192
36,325,457
parathyroid adenoma pregnanc case report systemat review literatur primari hyperparathyroid common disord parathyroid gland parathyroid adenoma pa pregnanc relat rare diseas whose diagnosi treatment challeng task aim present studi present new case parathyroid adenoma pregnanc give detail account report case parathyroid adenoma pregnanc literatur
D010282;D000236;D011252
T191
36,325,456
use chang sever simpl anthropometr indic predict occurr metabol syndrom find medic resourc communiti rural china various anthropometr indic prove use predict metabol syndrom met associ chang anthropometr indic onset met unclear studi select six indic easi measur calcul daili life evalu relationship
D024821
T047
36,325,455
fractur risk under pathophysiolog bone qualiti assess patient turner syndrom turner syndrom ts common type x chromosom disord various clinic manifest among primari hypogonad may lead osteoporosi life long health issu high preval fractur associ osteoporosi major problem patient ts may time higher healthi individu increas age among risk factor associ fractur ts hypogonad arguabl import estrogen defici due hypogonad lead low bone miner densiti bmd result high preval bone fractur estrogen replac therapi ert patient ts report improv bmd howev caus low bmd may exist given condit begin prepubert period patient ts previous studi report low bmd patient ts use dual energi x ray absorptiometri dxa method limit areal bmd valu assess dxa influenc bone size short statur result underestim bmd current volumetr bmd valu may accur obtain use peripher quantit comput tomographi pqct pqct high resolut pqct trabecular bone score also use evalu bone qualiti includ bone geometri microarchitectur ts present review discuss high fractur risk role estrogen defici low bmd advantag disadvantag various bone assess method characterist bone qualiti ts
D014424;D010024;D050723;D001851;D007006
T047;T037
36,325,454
signific radiofrequ ablat larg solid benign thyroid nodul aim studi explor efficaci safeti radiofrequ ablat rfa among case attack larg benign solid thyroid nodul main focus volum reduct complic rate thyroid function
D016606;D000078703;D017115
T061;T191
36,325,453
silent pheochromocytoma paraganglioma systemat review propos definit standard terminolog pheochromocytoma paraganglioma ppgls rare neuroendocrin tumor heterogen clinic present potenti lethal outcom diagnosi base clinic suspicion biochem test imag histopatholog confirm increas widespread use imag studi surveil patient risk ppgl due hereditari background previous tumor lead diagnosi tumor earli stage result increas use term silent ppgl term variant common found literatur without clear unifi definit among various term clinic silent often use describ lack sign symptom associ catecholamin excess confus aris term use defin tumor accord abil synthes andor releas catecholamin relat biochem test result case term silent variant often inappropri mislead use present analysi provid overview literatur propos standard terminolog attempt harmon facilit scientif communic
D010673;D010235;D000310
T191
36,325,452
beyond ps critic apprais non endocrin manifest multipl endocrin neoplasia type multipl endocrin neoplasia type men autosom domin inherit tumor syndrom classic defin tumor aris ps parathyroid pituitari endocrin pancrea earliest descript men associ endocrin non endocrin neoplast manifest high qualiti evid support direct associ pathogen men variant neoplasm skin angiofibroma collagenoma adipos tissu lipoma hibernoma smooth muscl leiomyoma although cns tumor melanoma recent breast cancer report men clinic manifest publish evid date yet suffici establish causal well design multicent prospect studi help us understand better relationship tumor men addit verifi true preval penetr well document neoplast associ nevertheless patient affect men awar non endocrin manifest provid encourag alway think beyond ps treat men patient
D018761;D018322;D007515
T023;T191
36,325,451
reduct risk contrast induc nephropathi patient chronic kidney diseas diabet mellitus enhanc extern counterpuls evalu efficaci enhanc extern counterpuls eecp prevent contrast induc nephropathi cin patient combin chronic kidney diseas ckd diabet mellitus dm compar chang renal function relat indic patient coronari angiographi cag percutan coronari intervent pci
D062645;D051436;D003920;D015908
T061;T047
36,325,450
compar effect endometri injuri luteal phase follicular phase vitro fertil treatment outcom sever studi shown endometri injuri improv clinic pregnanc outcom patient undergo vitro fertilizationintracytoplasm sperm inject ivficsi treatment histori implant failur howev endometri injuri perform follicular phase fp follow embryo transfer menstrual cycl luteal phase lp embryo transfer cycl
D008183;D005498
T079;T042
36,325,449
ctgf multifunct molecul cartilag potenti drug osteoarthr ctgf multifunct protein play differ role differ cell differ condit pamrevlumab monoclon antibodi ctgf fda approv drug idiopath pulmonari fibrosi ipf duchenn muscular dystrophi dmd recent studi shown ctgf antibodi may potenti serv new drug osteoarthr oa express ctgf signific higher oa joint healthi counterpart increas attent attract due interest role joint homeostasi joint homeostasi reli normal cellular function cell cell interact ctgf essenti physiolog activ chondrocyt abnorm ctgf express may caus cartilag degener review physiolog function ctgf chondrocyt relat mechan summar chang relat signal pathway due abnorm ctgf discuss contribut factor inflamm cartilag degener synovi fibrosi oa possibl ctgf potenti therapeut target oa treatment review
D010003
T047
36,325,448
high initi fsh dosag reduc number avail cleavag stage embryo gnrh antagonist protocol real world data ivf cycl china evalu relationship initi follicl stimul hormon fsh dose number avail cleavag stage embryo vitro fertil ivf cyclesw includ fresh ivf cycl use gnrh antagonist protocol genet reproduct institut chongq p r china januari june univari linear regress use evalu associ initi fsh dosag iu number avail cleavag stage embryo day two factor linear regress model appli calcul threshold effect initi fsh dosag number avail cleavag stage embryo base smooth plot initi fsh dose negat correl number avail cleavag stage embryo independ femal age bodi mass index infertil factor durat infertil anti mllerian hormon basal fsh level antral follicl count proport patient poor ovarian respons polycyst ovarian syndrom use two factor linear regress model calcul inflect point iu fsh relationship initi fsh dose number avail cleavag stage embryo nonlinear initi fsh dose negat associ number avail cleavag stage embryo initi fsh dose iu therefor clinician tri avoid unnecessarili increas initi fsh dose
D005640;D007246
T121;T116;T033;T125;T046
36,325,447
time rang assess continu glucos monitor associ brachial ankl puls wave veloc type diabet retrospect singl center analysi aim retrospect singl center research relationship time rang tir import novel metric glycem control assess continu glucos monitor cgm brachial ankl puls wave veloc bapwv uniqu index system arteri stiff type diabet
D003924;D002318
T047
36,325,446
treatment type diabet mellitus use tradit chines medicin jinlida add medic systemat review meta analysi random control trial numer random control trial rcts conduct china shown jinlida granul promis tradit chines medicin tcm treatment person type diabet mellitus tdm controversi result report differ rcts aim studi evalu adjuv hypoglycem effect jinlida granul person tdm explor sourc heterogen rcts
D008516;D003924
T060;T047;T091
36,325,445
effect covid present thyroid diseas children although studi suggest potenti link covid thyroid dysfunct adult insuffici data confirm associ children whether effect present healthcar servic
D000086382;D006980;D013959;D007037
T047;T067
36,325,444
associ caffein intak lumbar spine bone miner densiti adult age cross section studi mani epidemiolog studi investig connect coffe intak bone miner densiti bmd result controversi studi aim assess associ caffein consumpt lumbar bmd adult age
D015519;D002110
T201;T121;T081;T109
36,325,443
outcom affect factor icsi microtes treatment nonobstruct azoospermia patient differ etiolog retrospect analysi nonobstruct azoospermia noa common sever form male infertil microdissect testicular sperm extract microtes combin intracytoplasm sperm inject icsi optim treatment men noa howev outcom affect factor icsi noa patient differ etiolog receiv microtes treatment still unclear
D053713;D003456;D009920;D009107
T033;T019;T047
36,325,442
growth differenti factor modul bone muscl metabol studi aim clarifi potenti role growth differenti factor gdf myokin bone metabol muscl function femal osteoporosi total femal particip year distal radius fractur recruit particip classifi healthyosteopen n con osteoporot n op accord score areal bone miner densiti abmd femor neck bodi mass index upper arm calf circumfer handgrip strength assess total hip femor neck lumbar spine abmd measur via dual energi x ray absorptiometri focal bone qualiti distal radius evalu via reconstruct comput tomograph imag serum level gdf insulin like growth factor inflammatori marker tumor necrosi factor tnf interleukin interleukin il well correspond mrna level pronat quadratus muscl determin particip op group higher serum gdf level con group mrna level gdf il tnf pronat quadratus muscl signific higher op group con one level serum gdf gdf mrna muscl posit correl age negat associ abmd total hip focal bone qualiti distal radius handgrip power correl circul gdf level correl circumfer upper arm calf level gdf mrna muscl specimen mrna level gdf correl inflammatori cytokin tnf il mrna level tnf associ circumfer upper arm calf abmd total hip mrna level gdf muscl correl serum level gdf tnf gdf may associ bone metabol human via paracrinolog endocrinolog mechan mainten muscl mass function would influenc gdf muscl circul gdf role gdf bone metabol muscl homeostasi could relat inflammatori respons
D055436;D014409
T129;T116
36,325,441
aberr activ tgf induc high bone turnov via rho gtpase mediat cytoskelet remodel camurati engelmann diseas adult skeleton bone remodel process involv dynam coordin osteoblast osteoclast disrupt diseas high bone turnov rate dysregul transform growth factor beta tgf howev littl known tgf signal mediat bone resorpt describ pedigre heterozyg variant tgf rc result aberr activ tgf activ mechan caus camurati engelmann diseas ced show ced patient high level activ rho gtpase migrat relat protein integrin integrin peripher blood hekt cell transfect plasmid encod mutant express high level tgf activ rho gtpase furthermor activ rho tgf increas osteoclast format bone resorpt increas migrat pre osteoclast well cytoskelet remodel pre osteoclast matur osteoclast import pharmacolog inhibit rho gtpase effect rescu hyperact tgf induc osteoclastogenesi vitro overal propos rho gtpase mediat tgf induc osteoclastogenesi suggest rho tgf crosstalk associ high bone turnov ced
D003966;D001862
T047;T042
36,325,440
cisaprid induc hypoglycemia via kcnh potassium channel mutat kcnh prove caus hypoinsulinemia diabet human mice cisaprid stomach intestin motil drug use treat gastrointestin dysfunct cisaprid report potenti inhibitor kcnh famili remain unclear whether cisaprid inhibit kcnh discov role cisaprid glucos metabol focus kcnh potassium channel protein cisaprid reduc blood glucos level increas serum insulin secret wild type wt mice fed standard normal chowa high fat diet dbdb mice especi combin tolbutamid effect much stronger week intraperiton inject whole cell patch clamp show cisaprid inhibit kcnh current transfect hek cell concentr depend manner cisaprid induc increas insulin secret disrupt intracellular calcium homeostasi rat pancreat cell line in e experi reveal cisaprid decreas blood glucos increas serum insulin kcnh cell knockout kcnh ko mice compar wt mice cisaprid also amelior glucos stimul insulin secret gsis respons high glucos wt kcnh ko mice thus data reveal novel way effect kcnh cisaprid induc hypoglycemia
D001786;D007003
T047;T109
36,325,417
massiv hepatoma treat curat intent liver lobectomi standard poodl dog year old neuter male standard poodl seen veterinari clinic complet oral health assess treatment routin blood biochemistri reveal mark hepat enzymopathi gamma glutamyltransferas sever elev enzym liver lobectomi perform remov hepat tumor visual abdomin ultrasound examin despit concern cholestat disord biliari neoplasia histopatholog resect mass confirm massiv hepatoma left later liver lobe
D004283;D008113
T047;T191
36,325,414
veterinari student urethr catheter small femal cat dog use urethr catheter techniqu compar veterinari student success urethr catheter small femal cat dog use tradit novel cathet techniqu
D014546;D014521
T061;T023
36,325,412
comparison bidirect barb versus convent monofila sutur materi closur felin perin urethrostomi retrospect comparison bidirect barb absorb sutur materi convent absorb monofila sutur closur felin perin urethrostomi
D013537;D002371
T047;T074
36,325,411
superfici digit flexor tendon luxat repair abras calcaneoplasti primari retinaculum repair dog surgic treatment superfici digit flexor tendon luxat treatment choic sinc nonsurg treatment shown unsuccess dog attempt object studi report complic short long term outcom dog superfici digit flexor tendon luxat treat abras calcaneoplasti adjunct surgic techniqu addit tradit repair total client own dog superfici digit flexor tendon luxat examin retrospect case seri novel surgic techniqu use abras calcaneoplasti addit retinaculum imbric record review signal chronic clinic sign preoper diagnost test surgic techniqu postop complic outcom abras calcaneoplasti addit tradit primari retinaculum repair success perform dog ultim resolut clinic lame patient despit short term relux patient base find case seri infer abras calcaneoplasti consid addit tradit repair option treat luxat superfici digit flexor short term complic rate evid long term complic
D004204;D004283
T047;T037
36,325,410
gastric neuroendocrin carcinoma carcinoid ferret mustela putorius furo well differenti neuroendocrin carcinoma stomach gastric carcinoid transcoelom lymph node metastasi confirm post mortem examin year old spay femal domest ferret mustela putorius furo anim initi present histori persist vomit progress weight loss palpabl abdomin mass melena ferret receiv palliat treatment euthan mo initi present clinic ultrasonograph cytolog gross patholog histopatholog immunohistochem find describ gastric neuroendocrin carcinoma rare report anim first descript ferret key clinic messag veterinari practition diagnostician includ neuroendocrin carcinoma differenti diagnosi encount gastric neoplasm ferret awar potenti aggress behavior wide spread metastasi
D013274;D002276;D018278
T191
36,325,409
breed predilect prognosi subungu squamous cell carcinoma dog better document preval breed predilect clinic behavior subungu squamous cell carcinoma dog
D004283;D002294;D009260
T047;T191
36,325,408
revers sneez clinic manifest nasopharyng oropharyng fistula dog year old spay femal labrador retriev evalu month histori intermitt revers sneez gag episod pertin find evalu includ frequent revers sneez non product retch patholog visibl sedat oral examin contrast enhanc comput tomographi skull reveal gas fill defect within left ventral aspect soft palat non erod defect present left caudoventr nasopharyng wall nasopharyngoscopi surgic explor reveal nasopharyng oropharyng fistula within left palatin tonsillar fossa dog wit oropharyng stick injuri osi month previous locat fistula osi allow heal secondari intent treat oral antibiot nsaid howev dog lack characterist sign chronic osi nasal discharg abscess format defect soft palat surgic debrid close left palatin tonsil excis dog recov complet cessat revers sneez retch episod
D004283;D005402
T047;T190
36,325,407
protothecosi toxoplasma gondii co infect dog nova scotia canada year old neuter male mix breed dog nova scotia canada evalu panuv polyuria polydipsia hind limb ataxia toxoplasmosi diagnos ant mortem base mark increas toxoplasma gondii titer post mortem examin confirm system toxoplasmosi demonstr dissemin protothecosi articl document first report case canin protothecosi atlant canada key clinic messag case report demonstr protothecosi clinic consider dog canada co infect organ may occur may mask clinic sign potenti delay diagnosi
D014122;D060085;D004283;D014123;D014124
T047;T204
36,325,406
inadvert placement esophagostomi tube mediastinum cat year old neuter male siberian forest cat present respiratori distress endoscopi exploratori surgeri neck sternotomi confirm initi placement esophagostomi tube e tube mediastinum patient recov surgeri develop laryng paralysi arrest die within h surgeri key clinic messag author knowledg case report document inadvert placement e tube mediastinum cat case report highlight complic associ incorrect placement e tube
D004946;D008482
T061;T029
36,325,357
case report rare case coexist waldenstrom macroglobulinemia b cell acut lymphoblast leukemia kmtd mecom mutat waldenstrom macroglobulinemia wm rare indol lymphoma b cell origin character elev monoclon igm mydlp mutat cxcr mutat common molecular alter b cell acut lymphoblast leukemia b clinic heterogen character abnorm prolifer aggreg immatur lymphocyt bone marrow lymphoid tissu wm hematolog malign b cell origin complet differ clinic manifest biolog featur kmtd mecom mutat rare usual indic poor diseas prognosi coexist wm kmtd mecom mutat report
D008258;D016393;D002051;D054198
T191
36,325,356
tcr repertoir profil reveal antigen driven cd cell clonal group share synovi fluid patient spondyloarthr spondyloarthr spa compris number inflammatori rheumat diseas overlap clinic manifest strong associ sever hla allel cell infiltr inflam joint suggest involv cell spa pathogenesi studi perform high throughput cell repertoir profil synovi fluid sf peripher blood pb sampl collect larg cohort spa patient show synovi fluid enrich expand cell clone share patient similar hla genotyp persist recurr synov use algorithm identif tcrs involv immun respons discov sever antigen driven cd clonal group associ risk hla b hla b allel show clonal group enrich sf higher frequenc pb spa patient vs healthi donor impli relev spa pathogenesi sever group share among patient differ spas suggest common immunopatholog mechan diseas summari result provid evid role specif cd cell clone pathogenesi spa
D025241;D013585
T047
36,325,355
mirna profil diagnosi predict treatment outcom patient b chronic lymphocyt leukemia filo studi mani year chemo immunotherapi fludarabin cyclophosphamid rituximab fcr gold standard first line treatment medic fit patient symptomat b chronic lymphocyt leukemia cll last decad target biotherapi revolution treatment b cll patient almost entir supplant fcr howev biomark still exist predict complet remiss cr undetect minim residu diseas umrd bone marrow bm remain best predict factor surviv microrna repres class molecular biomark express alter b cll studi aim identifi treatment blood mirna predict treatment outcom previous untreat b cll patient nct https clinicaltrialsgovctshownct use hierarch cluster mirna express profil discrimin patient achiev cr bm umrd patient achiev cr display detect bm mrd identifi mirna differenti express treatment express mirna valid larger cohort n base dosag mirna diagnosi decis tree construct predict treatment outcom identifi group patient distinct probabl cr bm umrd fcr treatment rang mir b mir b mir c high mir b mir b low none patient display high express level mir b mir b mir c relaps studi follow contrast patient low mir b high mir low mir b mir b demonstr signific low pfs rna sequenc blood diagnosi identifi patient relaps treatment character signific enrich gene signatur relat cell cycl myc target gene metabol translat regul convers patient achiev cr bm umrd display signific enrich gene relat communic cll cell microenviron immun system activ upregul polycomb prc complex target gene result suggest blood mirna potent predict biomark fcr treatment efficaci might implic fcr efficaci b cll patient provid new insight unmet need treatment b cll patient identifi pathway predict patient remiss
D015451;D035683
T123;T191;T114
36,325,354
mechanotransduct skin wound heal scar format potenti therapeut target control hypertroph scar hypertroph scar hts major sourc morbid cutan injuri recent studi indic mechan forc signific impact wound heal skin regener open new direct combat scar henc thorough understand under mechan essenti develop efficaci scar therapeut review provid overview current understand mechanotransduct signal pathway scar format strategi offload mechan forc wound region scar prevent treatment
D040542;D017439
T020;T044