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biomedical-topic-categorization-validation

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36.4M
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36,322,416
round robin approach provid detail assess biomolecular small angl scatter data reproduc yield consensus curv benchmark expans intern effort involv data collect small angl x ray scatter sax four small angl neutron scatter san instrument sax san measur five protein ribonucleas lysozym xylanas urat oxidas xylos isomeras acquir data solvent subtract protein scatter profil shown reproduc caveat addit constant adjust requir account small error solvent subtract major featur obtain consensus sax data q measur rang consist theoret predict inher lower statist precis san limit reliabl measur q rang show good mutual agreement affirm region interpret featur structur model sas measur inlin size exclus chromatographi sec prove general superior elimin sampl heterogen unavoid sampl dilut column elut batch sas data collect higher concentr longer time provid superior statist precis care merg data measur use inlin sec batch mode low high concentr data batch measur success elimin small amount aggreg interparticl interfer scatter provid improv statist precis overal benchmark data set
D019985;D011506
T081;T123;T116
36,322,415
put alphafold model work phenixprocesspredictedmodel isold alphafold recent becom import tool provid model experiment structur determin x ray crystallographi cryo em larg part predict model typic approach accuraci experiment determin structur although frequent local error error relat orient domain import residu model protein predict alphafold tag predict local distanc differ test score inform user region structur predict less confid alphafold also produc predict align error matrix indic confid relat posit pair residu predict model phenixprocesspredictedmodel tool downweight remov low confid residu break model confid predict domain prepar molecular replac cryo em dock confid metric use isold weight torsion atom atom distanc restraint allow complet alphafold model interact rearrang match dock fragment reduc need rebuild connect region
D012984
T090;T170;T073
36,322,414
exit tunnel uncertainti crystal soak valid hit crystallograph fragment screen provid effici effect way identifi small molecul ligand crystal protein due low molecular weight hit tend low often unquantifi affin target complic twin challeng valid hit authent solut phase ligand target identifi best hit elabor articl approach address challeng assess use retrospect analysi recent atad hit identif campaign alongsid exampl success fragment screen campaign suggest hit valid priorit best achiev triangul approach result multipl avail biochem biophys techniqu correl develop qualit structur activ relationship sar qualit sar may inde mean navig project tunnel uncertainti prevail scale biophys biochem andor biolog measur becom possibl
D054852;D055808
T062;T170
36,322,413
verif model free phase enhanc predict model arcimboldoshredd structur predict match accuraci experiment structur close homologu provid suitabl model molecular replac phase even predict present larg differ due relat movement domain poor predict area accur region tend present suitabl success fragment base phase implement arcimboldo particular predict model inher address new predictedmodel mode render preliminari treatment superflu also harmless b valu convers predict lddt error estim remov unstructur polypeptid hierarch decomposit structur unit domain local fold systemat probe model experiment data ensur optim use model phase concomit exhaust use model stereochemistri phase refin valid rais concern crystallograph model bias need critic establish inform contribut experi therefor predictedmodel mode arcimboldoshredd first determin whether input model alreadi constitut solut provid straightforward solut phaser extract fragment locat landscap solut reveal numer clear discrimin consist probe input model alreadi constitut solut model free verif activ expans shelx omit partial solut seed phase trace outsid respect mask combin alix far consist procedur complet elimin molecular replac search model favour infer deriv model case fragment incorrect start hypothesi imped expans predictedmodel mode test differ scenario
D010455
T121;T116
36,322,407
predict molecular biomark determin neoadjuv chemosensit muscl invas bladder cancer identifi neoadjuv chemotherapi nac respons patient muscl invas bladder cancer mibc limit success base clinicopatholog featur molecular subtyp identif chemotherapi respons cohort would facilit deliveri like benefit
D001749;D035683
T123;T191;T114
36,322,319
curcumin inhibit invas epitheli mesenchym transit hepatocellular carcinoma cell regul tetwnt catenin signal axi molecular mechan flavonoid curcumin use cancer treatment fulli understood result studi suggest curcumin evid inhibit epitheli mesenchym transit cell growth invas hepatocellular carcinoma cell line hepg huh well wnt catenin signal pathway curcumin might exert anti tumor effect hepatocellular carcinoma cell regul tetwnt catenin signal pathway inhibit epitheli mesenchym transit progress
D006528;D003474;D008113
T121;T191;T130;T109
36,322,318
chang express transcript factor oct postnat develop adren medulla analyz express transcript factor oct chromaffin cell postnat develop adren gland rat singl oct chromaffin cell nuclear local protein found medulla number increas parallel decreas prolif activ cell postnat develop chromaffin cell demonstr high express tyrosin hydroxylas attest differenti function activ found oct cell differenti chromaffin cell increas pool oct express cell complet organ growth suggest format potenti sourc physiolog repar regener adren medulla
D000313;D019439
T023;T025
36,322,317
biocompat titanium oxynitrid coat deposit reactiv magnetron sputter titanium oxynitrid coat deposit reactiv magnetron sputter improv biocompat vascular stent increas product viabil adhes eahi cell thus applic titanium oxynitrid coat promis strategi increas biocompat nitinol stent
D014025;D015607
T196;T074
36,322,316
problem vascular precancer lesion colon develop hypoxia incipi stage blastomogenesi featur blood suppli colon mucosa develop hyperplast dysplast process earli neoplast lesion studi studi cohort compris materi patient n n blokhin nation medic research center oncolog collect initi stage hyperplast atyp process develop background enhanc angiogenesi develop adenomatosi concomit dysplasia blood suppli newli form structur decreas associ overexpress marker tissu hypoxia hif caix glut express marker maxim foci high pronounc dysplasia detect foci carcinoma situ microinvas cell reach stroma abund vascular suppli hypothes hypoxia forc cell search territori suffici vascular migrat structur final manifest invas destruct adjac tissu dissemin cell bodi format metastasi
D011230;D015179
T191
36,322,315
hypothyroid model wistar rat comparison two surgic method studi present surgic model hypothyroid male wistar rat n base total thyroidectomi anim weigh g random divid sham oper group experiment group thyroidectomi perform differ method primari ligat either thyroid arteri te vein te ii success model verifi general postop condit serum hormon level histolog studi neck ultrasound hypothyroid success reproduc te te ii model te character lower intra post oper mortal te ii provid better surgic exposur key anatom site
D007037
T047
36,322,314
model chronic lung inflamm rat repeat intratrach administr lps model chronic lung inflamm spf spragu dawley rat develop repeat intratrach administr lps dose mgkg day studi male rat treat lps relat monocytopenia reduc mean concentr hemoglobin erythrocyt mean platelet volum comparison control anim salin intratrach administr lps induc inflammatori process lung character focal atelectasi compensatori emphysemat expans subpleur pulmonari acini focal mononuclear neutrophil perivascular peribronchi infiltr minor focal mononuclear neutrophil infiltr alveolar wall background lps administr germin center appear lymphoid follicl white pulp spleen focal mononuclear infiltr tracheal mucosa andor submucosa observ anim
D008070;D011014
T047;T050;T109
36,322,313
compar studi level il il il tnf ifn stabl cours exacerb chronic obstruct pulmonari diseas vari sever patient chronic obstruct pulmonari diseas level cytokin il il il tnf ifn depend degre bronchial obstruct sever period diseas maximum level il il tnf observ sever chronic obstruct pulmonari diseas exacerb highest concentr il ifn record activ inflamm patient moder bronchial obstruct reveal correl test cytokin spirometri paramet make possibl consid level protein quantit marker system inflamm progress
D014409;D029424
T129;T047;T116
36,322,312
suppress antioxid system pikaktmtor signal pathway cisplatin resist cancer cell quercetin studi effect quercetin ovarian adenocarcinoma skov cell line isogen sublin skov cddp resist anticanc drug cisplatin found resist cell quercetin concentr caus decreas cell viabil suppress express gene encod key antioxid enzym sod cat gpx ho transcript factor nrf kinas pikaktmtor signal pathway parent cell quercetin contrari increas express gene result confirm redox depend regul induc quercetin opposit natur cisplatin sensit cisplatin resist cancer cell
D002945;D010051
T121;T197;T191
36,322,311
role carbon monoxid reaction arteri branch uterin arteri rat low intens irradi helium neon laser biomicroscopi use studi order iv branch uterin arteri sexual matur femal wistar rat singl min direct exposur right broad ligament uterus helium neon laser beam red band spectrum nm output power mw intens mwcm influenc laser exposur signific increas diamet small uterin branch weaker increas larg vessel well develop muscular membran preliminari administr zinc ix protoporphyrin hemoxygenas blocker mmolkg reduc reactiv vascular bed laser irradi main order ii branch conclud carbon monoxid act intermediari laser exposur uterin vessel
D055988;D002248
T131;T023;T197
36,322,310
glutathion compon antioxid status menopaus women insomnia studi involv women age year perimenopaus n postmenopaus n insomnia main group without control level reduc gsh oxid gssg glutathion glutathion peroxidas activ determin erythrocyt activ glutathion transferas glutathion reductas measur blood serum differ control group found perimenopaus higher glutathion reductas activ reduc gssg level gshgssg ratio women insomnia p result compar analysi main group show lower glutathion reductas activ increas gssg level decreas gshgssg ratio postmenopaus period compar perimenopaus p result use choos tactic complex therapi insomnia menopaus women correct free radic homeostasi prevent oxid stress
D000975;D007319
T123;T121;T048;T184;T039;T044;T047
36,322,309
relationship adenosin deaminas activ cerebr cortex stimul effect caffein adult wistar rat differ age aim studi test hypothesi higher activ adenosinedeaminas ada brain greater motor activ anim possibl stronger psychostimul effect caffein studi effect caffein mgkg motor activ ada activ frontal cortex brain month old rat differ level spontan motor activ total motor activ signific decreas age accompani decreas ada activ administr caffein dose mgkg stimul motor activ month old anim ada activ decreas month old rat increas month old anim administr caffein dose mgkg chang motor activ howev month old anim led even greater increas ada activ thus age relat decreas motor activ due decreas ada activ howev effect caffein motor activ direct relat ada activ cerebr cortex
D002110;D000243
T121;T126;T116;T109
36,322,308
hypermethyl long non code rna gene group breast cancer develop progress analyz chang level methyl cpg island four long non code rna lncrna gene meg znf gas semab promis marker breast cancer methyl analysi perform quantit methyl specif pcr set pair tumornorm breast cancer sampl signific p increas methyl shown three four lncrna gene meg znf semab found signific correl methyl level studi lncrna gene stage cancer lymphogen metastasi meg znf also tumor size methyl znf semab gene breast cancer detect first time base find new potenti marker diagnosi prognosi breast cancer propos
D062085;D001943
T123;T191;T114
36,322,307
langendorff isol rat heart acut experiment myocardi infarct compar analysi function langendorff isol heart intact rat sham oper rat rat model myocardi infarct one day ligat left coronari arteri carri signific differ inotrop chronotrop function heart found group intact sham oper anim group rat myocardi infarct model increas hr decreas maximum contract relax rate left ventricular develop pressur shown comparison group intact sham oper anim time group sham oper anim decreas coronari flow tempor paramet contract observ
D009203
T047
36,322,306
function state various type regen compet neural tissu cell amyloid induc neurodegener analyz content function activ various type regen compet cell subventricular zone cerebr hemispher experiment mice condit vitro model amyloid induc neurodegener fundament differ opposit effect amyloid function activ multipot neural stem cell nsc neuron commit progenitor ncp reveal amyloid suppress prolifer nsc stimul differenti time increas mitot activ ncp observ decreas intens special chang function progenitor cell develop background signific drop product neurotroph growth factor neuroglia phenomena indic mark discoordin activ regen compet cell various type
D016229;D058953
T116;T025
36,322,305
energi status lymphocyt children bronchial asthma various sever comparison frequent ill healthi children studi disturb cellular energi exchang one lead factor develop chronic inflamm asthma comparison indic mitochondri respir glycolysi lymphocyt children bronchial asthma differ sever children group frequent ill condit healthi children show degre impair energi metabol correl sever diseas mild compens cours bronchial asthma well group frequent ill children increas activ oxid phosphoryl observ also accompani support form glycolysi activ suggest energi suppli mechan preserv serious case moder bronchial asthma mitochondri respir hyperactiv suppress even absenc glycolysi cell children sever bronchial asthma depress studi dehydrogenas observ probabl unfavor prognost sign result make possibl determin indic choic basic therapi drug serv prognost marker sever cours diseas
D001249
T047
36,322,304
selank peptid analog tuftsin attenu avers sign morphin withdraw rat activ peptid tuftsin analogu selank studi outbr rat use naloxon precipit morphin withdraw model singl intraperiton inject selank anxiolyt dose mgkg reduc total index morphin withdraw syndrom signific attenu convuls reaction ptosi postur disord fold increas tactil sensit threshold morphin depend rat comparison group activ control time selank slight inferior diazepam dose mgkg pharmacolog activ decreas total index morphin withdraw syndrom fold increas sensit threshold thus selank like diazepam weaken avers sign morphin withdraw rat opiat depend
D014405;D009021;D013375
T129;T184;T116;T048
36,322,303
experiment evalu effect isobornylphenol model pathospermia effect antioxid prooxid balanc male germ cell studi effect antioxid dibornol diisobornyl methylphenol deriv hydroxymethyl diisobornylphenol member alkyl phenol group redox potenti male germ cell morpholog function state rat model pathospermia pharmacolog effect observ anim treat dibornol studi compound led normal antioxid prooxid balanc howev valu indic background treatment dibornol deriv attest shift redox balanc cell toward reduct reaction
D000975;D010636
T123;T121;T109;T039;T044
36,322,302
featur humor respons infect vaccin revaccin covid igm igg antibodi sar cov virus detect subject recov covid igm antibodi persist infect subject month moment diseas igg antibodi present vast major case medium high level antibodi regist case th month recov still high level igg antibodi protein bauml fece urin blood serum patient long term persist igm antibodi coronavirus antigen detect vaccin gam covid vac vaccin igg antibodi protein detect case remain high level month th month level antibodi decreas revaccin level igg antibodi protein reach high valu earlier primari vaccin remain high month observ period blood sera recov vaccin patient high virus neutral activ least level somewhat higher recov patient
D000914;D000086382
T129;T047;T116;T067
36,322,292
materi gradient gastropod radula biomechan signific combin approach paludomid lavigeria grandi radula chitin membran spike teeth molluscan autapomorphi gather process food teeth actual interfac organ ingesta act load transmit region withstand high stress forag without structur failur high degre wear mechan contribut studi previous paludomid gastropod lake tanganyika speci gradient hard young modulus along teeth detect enabl bend reli teeth onto next row distribut stress equal present studi one lavigeria grandi aim shed light origin function gradient mechan properti identifi nanoindent techniqu compar element composit determin element dispers x ray spectroscopi edx ed done complet radular matur immatur tooth row result overal edx nanoindent measur even though teeth show region differ element composit could correl mechan gradient element proport appli confoc laser scan microscopi clsm final abl relat mechan properti degre tan clsm common techniqu use arthropod cuticl never appli radular teeth general found nanoindent clsm techniqu complement one anoth exampl clsm capabl reveal heterogen materi micro gradient lead better understand function biolog materi structur
D049851;D014070
T023;T204
36,322,261
factor associ inform breach healthcar facil systemat literatur review systemat review aim identifi factor associ inform breach healthcar set search electron databas includ pubm embas scopus wiley public march start date restrict outlin elig criteria framework use popul concept context pcc search strategi yield result nine studi includ final review group factor attribut data breach four categori organiz inform technolog professionalsemploye clientspati hospit type hospit size bed higher operationalexpens revenu higher admiss discharg higher electron medic record emr use earlier phase emr adopt associ higher inform breach profession factor type personnel involv hospit area potenti impact breach frequenc magnitud patient sociodemograph clinic behavior characterist gender educ attain appear influenc perceiv breach confidenti healthcar set identifi differ factor contribut health inform breach crucial protect healthcar organ patient devast consequ data breach
D003219;D057286
T078;T170;T073
36,322,254
differ face attitud behavior mimicri descript new termitophil speci remark rove beetl genus thyreoxenus staphylinida aleocharina corotocini brazil note post imagin growth among termit associ fauna rove beetl subfamili aleocharina distinguish exhibit major converg evolut lifestyl phenomenon known termitophili bring mani advantag includ care nestmat exploit resourc mechan ensur integr termitophil coloni well known chemic mimicri other remain unclear articl discuss import termitophil behavior stabil interact within termit coloni address behavior mimicri import integr mechan termitophil termit compar termitophil termit behavior repertoir found signific differ suggest social parasit mislead host behavior order exploit coloni keep posit interact host addit describ new speci termitophil rove beetl highland humid forest northeastern brazil thyreoxenus alakazam sp nov detail illustr comment post imagin growth context hypothesi post imago phenotyp known stenogastri recapitul ancestr condit physogastr rove beetl
D001517;D020049
T204
36,322,252
evalu aminoacetophenoneoxim deriv oxim schiff base new antimicrobi agent schiff base may core synthes differ new chemic ligand also mani biolog activ azomethin group antimicrobi activ new synthet oxim deriv bacteria fungi investig aminoacetophenoneoxim aaox aminoacetophenoneoxim aaox use precursor synthesi five oxim deriv ligand l two trident l l deriv aaox three bident l l l deriv aaox structur prepar ligand confirm use ft ir nmr h c uv visibl spectral analysi well melt point element analysi antimicrobi activ five ligand determin disk diffus method aaox ligand show antimicrobi action l effect ligand test microorgan especi staphylococcus aureus mic mgml candida glabrata mic mgml l ligand show antifung effect kocuria rosea resist ligand candida albican suscept conclus aaox deriv activ compound bacteria fungi aaox deriv ligand l inhibitori effect bacteria fungi inhibit aaox deriv new schiff base aaox deriv may regard promis antimicrobi agent
D012545;D000890
T121;T109
36,322,245
full digit workflow prefabr implant support interim restor case report novel techniqu articl describ case full digit procedur prefabr implant support interim restor base preoper digit implant plan fulli guid surgic templat design print interim restor fabric base plan implant posit dental comput aid design cad softwar implant place predetermin posit fulli guid surgic guid prefabr interim restor could insert immedi surgeri guid heal soft tissu enhanc esthet outcom novel techniqu elimin convent impress make insert implant support interim restor immedi implant placement surgeri guid heal soft tissu minim chairsid time optim clinic workflow
D017267;D015921
T170;T074
36,322,222
molecular investig outbreak ovin theileriosi among sheep goat haryana india februari octob four outbreak theileriosi small rumin record overal morbid mortal case fatal rate respect diseas character high fever f superfici lymphadenopathi anaemia anorexia lethargi respiratori distress death presenc pleomorph intra erythrocyt piroplasm theileria speci giemsa stain blood smear common find episod signific haematolog alter includ high total leucocyt count low haemoglobin pack cell volum characterist necropsi find icter liver enlarg spleen pulmonari oedema abomas ulcer observ three flock smear posit blood sampl episod screen pcr use rrna gene specif primer set lestoquardi luwenshuni uilenbergi ovi lestoquardi detect four flock co infect ovi two flock phylogenet analysi reveal ovi lestoquardi identifi studi homolog respect publish sequenc use comparison first confirm report outbreak malign ovin theileriosi haryana state india caus high morbid mortal case fatal among sheep goat studi theilerios small rumin requir understand epidemiolog better
D013801;D012757;D016794;D002418;D015511
T047;T204
36,322,195
stabil improv polyanilin nanocomposit immunosensor earli detect insulin receptor antibodi biomark type diabet polyanilin nanocomposit control properti use design fabric novel electrochem immunosensor earli detect type diabet insulin receptor antibodi power predictor type diabet develop individu systemat studi carri investig effect differ polyanilin layer nafion layer morpholog chemic electrochem properti nanocomposit immunosensor especi stabil bioengin nafion au nanoparticl polyanilinegold electrod demonstr outstand electrocatalyt perform detect insulin receptor antibodi high sensit ang mlcm linear rang ngml well low detect limit pgml respons time within min remark select signific stabil day therefor develop immunosensor suitabl nanocomposit platform insulin receptor antibodi level determin human plasma
D015374;D053768;D003924;D053761
T047;T059;T073;T075
36,322,139
metal ion induc evolut phenylalanin self assembl structur polymorph novel metast intermedi self assembl aromat amino acid wide studi due abil form well defin amyloid like fibrillar structur herein first time report exist differ metast intermedi state divers morpholog exampl droplet sphere vesicl flower toroid sequenti form aqueous medium self assembl process phenylalanin presenc differ dival zn cd hg trival al ga metal ion low p k valu due metal ion amino acid coordin strong hydrophob interact induc metal ion spheric aggreg obtain initi stage structur evolut transform intermedi state work may facilit understand role metal ion amino acid self assembl process broaden futur applic obtain nanostructur drug deliveri tissu engin bioimag biocatalysi field
D010649;D008670
T123;T197;T121;T116
36,322,127
bring cell edg network open channel allow cell molecular cargo travel center peripheri lab grown coloni pseudomona aeruginosa help erad compet speci
D013211;D018441
T007
36,322,124
onlin health inform seek among patient chronic condit integr health belief model social support theori chronic diseas lead caus death disabl grow patient popul climb health care expenditur research polici maker seek new approach improv access health inform chronic diseas lower cost onlin health inform sourc play substanti role effect patient educ health communic howev contradictori evid suggest patient chronic condit may necessarili seek onlin health inform
D057226;D057220
T055;T041
36,322,123
cost effect analysi mobil phone base integr hiv prevent intervent among men sex men china econom evalu mobil phone base digit intervent shown promis strategi hiv prevent among men sex men msm
D015658;D000163;D000072339;D040421
T047;T098;T073
36,322,120
digit coach use smart inhal technolog improv asthma manag patient asthma itali communiti base studi relianc short act agonist nonadher mainten medic associ poor clinic outcom asthma digit health solut could support optim medic use therefor diseas control patient asthma howev use communiti set determin
D000071252;D001249
T065;T047
36,322,107
nurs led telehealth intervent rehabilit telerehabilit among communiti dwell patient chronic diseas systemat review meta analysi chronic diseas put huge pressur health care system nurs wide recogn one compet health care provid offer comprehens care patient rehabilit hospit recent year telerehabilit open new pathway nurs manag chronic diseas distanc howev remain unclear chronic diseas patient benefit innov deliveri mode
D000069350;D017216;D003920;D006331;D006973
T058;T047
36,322,102
safeti pattern survivorship recurr gbm follow resect surgic target radiat therapi result prospect trial treatment recurr glioblastoma gbm remain problemat surviv addit therapi typic less month prospect evalu whether outcom might improv resect plus perman implant novel radiat devic util gamma emit isotop cs embed within bioresorb collagen tile
D001932;D005909
T191
36,322,101
turn light brain tumor surgeri aminolevulin acid stori aid surgeon complet safe resect brain tumor adjuv technolog develop improv visual target tissu fluoresc guid surgeri reli use fluorophor specif light wavelength better delin tumor tissu inflamm area blood brain barrier breakdown aminolevulin acid ala first fluorophor develop specif brain tumor accumul within tumor cell improv visual tumor core infiltr margin describ background ala integr modern neurosurgeri practic clinic evid current use ala futur direct role neurosurg oncolog maxim safe resect remain standard care brain tumor gross total resect high grade glioma hggs associ greater overal surviv progress free surviv pfs comparison subtot resect adjuv treatment therapi alon major challeng neurosurgeon encount resect infiltr glioma identif glioma tumor margin perform radic resect avoid preserv eloqu region brain aminolevulin acid ala remain optic imag agent approv fda use glioma surgeri identif tumor tissu multicent random control trial reveal ala fluoresc guid surgeri fgs almost doubl extent tumor resect also improv month pfs review highlight current evid use ala fgs brain tumor surgeri well discuss futur direct use
D005910;D001932;D025321
T061;T191
36,322,100
stereotact target radiat therapi start trial brain neoplasm comprehens review mainstay radiat therapi includ extern beam radiat therapi ebrt intern implant radiat brachytherapi bt distinct benefit risk term local distant tumor control normal brain toxic respect gammatil surgic target radiat therapi start attempt limit drawback bt paradigm via perman implant bioresorb conform collagen tile contain four uniform intens radiat sourc thus prevent deleteri direct contact brain optim interse space homogen radiat exposur safeti feasibl gammatil start therapi establish multipl clinic trial encompass spectrum primari secondari brain neoplasm recurr newli diagnos implant gt tile fda approv use recurr intracrani neoplasm expand newli diagnos malign intracrani neoplasm current spectrum trial focus better defin relat efficaci safeti non gt standard care radiat strategi intracrani brain neoplasm summar key design elig criteria open futur trial gt therapi includ registri random trial newli diagnos recurr brain metastas well recurr newli diagnos glioblastoma combin approv therapi
D016634;D001932;D001918
T061;T191
36,322,099
laser hyperthermia past present futur magnet reson imag guid laser interstiti thermal therapi litt ablat procedur use heat laser provid cytoreduct tissu minim invas procedur use intracrani patholog high grade glioma metastat lesion epilepsi lesion litt may offer accept complic profil compar open surgeri role laser therapi intracrani lesion current treatment paradigm continu evolv review focus background applic litt current evid use futur direct technolog
D001932;D005910;D053685;D006979
T061;T191;T074
36,322,098
updat intraop strategi enhanc intra axial brain tumor control ensur excel postop clinic outcom preserv critic neurolog function neurosurgeon manag patient intra axial brain tumor use intraop technolog tool achiev maxim safe resect neurosurg oncolog revolv around safe optim extent resect dictat subsequ treatment regimen patient outcom various method adapt treat primari secondari intra axial brain lesion present review recent advanc publish research center differ innov tool techniqu includ fluoresc guid surgeri new method drug deliveri minim invas procedur option
D005910;D001932
T191
36,322,097
spinal brachytherapi brachytherapi remain underrecogn underutil radiat therapi modal treatment spinal tumor articl summar exist bodi medic literatur usag indic techniqu outcom brachytherapi treatment spine tumor diseas patholog common treat brachytherapi metastat spine cancer rather primari bone tumor spine brachytherapi use alon percutan needl inject howev often use conjunct open surgeri cement vertebr bodi augment although data still relat spars studi show consist benefit brachytherapi term improv pain function local recurr rate overal surviv brachytherapi also associ favor complic profil
D001918;D013125
T061;T191
36,322,096
novel intraop strategi enhanc tumor control futur direct maxim safe surgic resect play key role care patient glioma rang technolog develop aid surgeon distinguish tumor normal tissu goal increas tumor resect limit postop neurolog deficit technolog current investig aid improv tumor control includ intraop imag modal fluoresc tumor maker intraop cell molecular profil tumor improv microscop imag intraop map augment virtual realiti intraop drug radiat deliveri ablat technolog review summar aforement advanc neurosurg oncolog implic improv patient outcom
D001932;D005910
T191
36,322,090
covid case investig contact trace new york citi june octob contact trace core strategi prevent spread mani infecti diseas public health concern better understand outcom contact trace covid well oper opportun challeng establish program jurisdict larg new york citi nyc import evalu strategi
D016358;D000086382
T058;T067;T047
36,322,089
evalu clinic safeti outcom neoadjuv immunotherapi combin chemotherapi patient resect esophag cancer systemat review meta analysi consider number clinic trial neoadjuv immunotherapi patient resect esophag cancer emerg howev systemat evalu studi lack
D004938;D000077277;D000230
T191
36,322,088
associ taxan type patient report chemotherapi induc peripher neuropathi among patient breast cancer understand detail symptom spectrum chemotherapi induc peripher neuropathi cipn could facilit share decis make promot earli intervent
D001943;D010523;D000970
T121;T047;T191;T109
36,322,087
associ pediatr buccal epigenet age acceler advers neonat brain growth neurodevelopment outcom among children born preterm neonat infect preterm neonat week gestat remain higher risk morbid neurodevelopment advers throughout lifespan extent prematur alon fulli explain risk advers neonat brain growth neurodevelopment outcom need neonat biomark help estim risk popul
D062071;D007235
T047;T100
36,322,086
transit health insur perinat period among patient continu insur coverag although health insur continu import perinat period improv birth outcom reduc matern morbid mortal insur disrupt common howev littl known insur transit among insur type individu remain insur perinat period
D007348;D019458
T078;T058
36,322,085
provis air condit heat relat mortal texa prison larg bodi epidemiolog evid heat associ increas risk mortal one effect strategi mitig effect heat air condit ac texa regul intern temperatur jail stay f degre standard appli state privat prison
D011330;D000389
T068;T073
36,322,084
assess unmet health relat social need among patient mental ill enrol medicar advantag larg bodi literatur found associ unmet health relat social need hrsns advers mental health outcom compar analysi risk associ hrsns among patient vari sever mental ill assess risk compar individu without mental ill need
D020398;D001523
T033;T089;T048
36,322,083
associ promot hous afford stabil improv health outcom systemat review hous insecur difficulti hous afford stabil preval result increas risk homeless poor health howev whether intervent prevent hous insecur upstream homeless improv health remain uncertain
D000086382;D006703
T098;T067;T033;T047;T095
36,322,082
estim save opportun therapeut substitut high cost generic medic use generic general understood cost save practic howev pharmaci benefit manag incent place higher price generic drug insur drug formulari profit creat larg differ price negoti pharmaci price paid insur known spread price
D016568;D057915
T121;T058
36,322,079
associ among visual auditori olfactori function communiti base older adult atherosclerosi risk communiti aric studi object examin relationship among visual hear olfactori function may yield mechanist insight inform understand burden multipl sensori impair
D050197;D006973;D003920
T047;T046
36,322,076
central peripher vision influenc focal ambient process scene view central peripher vision carri differ function scene process ambient mode visual process like involv peripher visual process wherea focal mode visual process like involv central visual process although ambient mode respons navig space comprehend scene layout focal mode gather detail inform central vision orient salient area visual field previous work suggest time cours scene view transit ambient process first second focal process later time interv character longer fixat shorter saccad studi identifi influenc central peripher vision chang eye movement transit ambient focal process time cours scene process use gaze conting protocol restrict visual field central peripher vision particip freeli view scene second result indic fixat durat shorter vision restrict central vision compar normal vision late visual process fixat peripher vision longer central vision show transit ambient focal process scene view occur even vision restrict central vision peripher vision
D005403;D014796
T041;T042
36,322,075
explor frame effect probe flash within move frame dramat displac zkan ansti hart wexler cavanagh wong mack effect much larger seen static move probe induc motion duncker wallach bacon schulman flash probe often perceiv separ frame coordin effect zkan et al explor frame effect flash test sever version standard stimulus find frame effect hold smooth abrupt displac frame even frame chang shape orient end point travel path could nonlinear even circular effect driven perceiv physic motion compet overlap frame effect determin frame attend number constraint limit effect static anchor near flash suppress effect extend static textur probe continu rather flash effect abolish observ report onlin particip suggest frame effect robust mani variat shape path lead percept flash test locat relat frame frame stationari result highlight role frame continu group flash frame generat frame effect
D009039
T041
36,322,067
potenti collid bias studi examin associ central corneal thick glaucoma central corneal thick cct may biolog relat glaucoma observ associ glaucoma simpli due effect intraocular pressur iop measur aim determin previous report cct glaucoma associ analys adjust iop particip select iop could explain collid bias
D005901;D009798
T047
36,322,066
clinic relev parafov intercapillari space foveal avascular zone diabet retinopathi without macular edema investig clinic signific intercapillari space swept sourc optic coher tomographi angiographi imag diabet retinopathi
D008269;D003930;D012164;D003920
T047
36,321,969
risk factor adjac segment diseas follow anterior cervic discectomi fusion plate fixat systemat review meta analysi adjac segment diseas asd follow anterior cervic discectomi fusion plate acdf p may yield poor prognosi reoper review aim summar risk factor radiograph asd rasd clinic asd casd acdf p
D013123;D055959
T061;T047;T190
36,321,933
dawn new day brief histori stroke treatment iceland briefli review main influenti factor mileston histori stroke care iceland last decad treatment ischem stroke revolution mani way general mindset provid review articl part base upon interview iceland doctor partook develop look back histori clear mani way medic care iceland forefront implement emerg new treatment stroke care main account ambiti hard work individu easili dissuad firm believ possibl better outcom stroke patient
D002545;D020521
T047;T046
36,321,932
transient global amnesia reykjavik area transient global amnesia tga benign syndrom character sudden anterograd memori loss resolv spontan within hour tga appear without focal neurolog symptom aim studi studi tga greater reykjavik area
D020236
T048
36,321,931
cardiac transplant donat iceland patient indic outcom inform number indic outcom cardiac transplant iceland patient scarc inform number heart donat iceland cardiac transplant
D016027;D006353;D016040
T061;T074
36,321,927
relationship sporad behavior variant frontotempor dementia primari psychiatr disord studi famili background behavior variant frontotempor dementia bvftd show major clinic overlap primari psychiatr disord ppd affect similar neuroanatom circuit common genet vulner ftd ppd hypothes
D057180;D000067877;D001714;D000544
T047;T048
36,321,921
correl psychotrop use major depress disord adhd research diagnos trend prospect pediatr cohort age object examin associ psychotrop usag clinic characterist pediatr research cohort research diagnos sever score
D001289;D003865;D014150
T121;T039;T048
36,321,876
visual experi oppos influenc qualiti stimulus represent adult primari visual cortex transient dark exposur typic day durat follow light reintroduct emerg treatment improv restor vision amblyop subject whose occlus remov adulthood dark exposur initi homeostat mechan togeth light induc chang cellular signal pathway result engag juvenil like plastic adult previous depriv input gain cortic territori possibl dark exposur degrad visual respons could place constraint optim durat dark exposur treatment determin whether eight day dark exposur last negat impact respons classic grate stimuli neural activ record dark exposur awak head fix mice use two photon calcium imag neural discrimin assess use classifi transient reduc follow dark exposur decreas respons reliabl across broad rang spatial frequenc like contribut disrupt discrimin reliabl recov fix classifi use demonstr stimulus represent rebound origin pre depriv state thus dark exposur appear last negat impact visual process unexpect found dark exposur signific stabil orient prefer signal correl result reveal natur vision exert disrupt influenc stabil stimulus prefer classic grate stimuli time improv neural discrimin low high spatial frequenc stimuli
D014793;D000550
T023;T029;T047
36,321,865
microglia shape embryon develop mammalian respiratori network microglia brain resid macrophag play key role prenat develop defin neural circuitri function includ ensur proper synapt wire maintain homeostasi mammalian breath rhythmogenesi aris interact brainstem neural network assembl embryon develop specif role microglia process remain unknown investig anatom function consequ respiratori circuit format absenc microglia first establish normal distribut microglia within wild type wt spi pu wt mous mus musculus brainstem embryon age respiratori network known emerg embryon day e parafaci respiratori group epf e prebtzing complex prebtc transgen mice deplet microglia spi pu ko mutant perform anatom stain calcium imag electrophysiolog record neuron activ vitro assess status circuit respect time function emerg spontan respiratori relat activ record reduc vitro prepar show abnorm slow rhythm frequenc express epf e prebtc e phrenic motor nerv e onward deficit associ reduc number activ epf neuron defect commissur project coupl bilater prebtc half center accompani decreas function coordin abnorm probabl contribut eventu neonat death sinc plethysmographi reveal e spi embryo unabl sustain breath activ ex utero result thus point crucial contribut microglia proper establish central respiratori command embryon develop
D012125;D017628
T023;T025
36,321,842
develop exposur burden score chemic mixtur use item respons theori applic pfas mixtur exist method quantifi total exposur burden chemic mixtur independ health outcom summari metric could advantag use biomonitor risk assess health risk calcul mediat model
D005466;D017738;D004785
T131;T109
36,321,828
cardiac develop presenc cadmium vitro studi use human embryon stem cell cardiac organoid exposur cadmium cd associ cardiovascular diseas matern cd exposur signific risk factor congenit heart diseas howev mechan cd development cardiotox well defin
D000066449
T025
36,321,796
ubiquitinspecif proteas amelior lipopolysaccharideinduc spleen injuri via suppress nfb mapk signal pathway human immun spleen major organ central humor cellular immun vitro vivo inflamm regul ubiquitinspecif proteas usp howev best knowledg effect usp spleen injuri remain unknown present studi aim investig protect offer usp spleen injuri lipopolysaccharid lps induc mice via attenu inflamm total cblj mice place follow group control group salin group lps group usp group usp lps group negat control nc lps group usp lentivirus inject mice x tuml intracerebroventricular day lps administ via intraperiton inject gkg group serum spleen sampl collect analysi histolog imag use examin spleen structur western blot use detect express level protein associ mitogenactiv protein kinas mapk nuclear factor nf b signal pathway proinflammatori cytokin detect use enzymelink immunosorb assay compar salin control usp lps group spleen volum lps group mark increas width splenic cord sinus exhibit morpholog damag lps group compar salin control usp lps group protein express level usp spleen decreas lps group furthermor product lpsinduc proinflammatori cytokin eg interleukin tumor necrosi factor reduc serum spleen homogen usp relat inflammatori pathway includ nfb mapk pathway downregul usp lps group compar lps group conclus antiinflammatori effect usp lpsinduc spleen injuri may mediat inhibit mapk nfb signal pathway
D008070;D016328
T129;T116;T109
36,321,793
exosom deriv dental pulp stem cell acceler cutan wound heal enhanc angiogenesi via cdcp mapk pathway skin wound heal common challeng clinic issu requir advanc treatment strategi present studi investig therapeut effect exosom deriv dental pulp stem cell dpscexo cutan wound heal under mechan effect dpscexo cutan wound heal mice examin measur wound closur rate use histolog immunohistochem analysi seri function assay perform evalu effect dpscexo angiogen activ human umbil vein endotheli cell huvec vitro tandem mass tagbas quantit proteom analysi dpscs dpscexo perform gene ontolog kyoto encyclopedia gene genom pathway enrich analys use evalu biolog function pathway differenti express protein dpscexo western blot analysi use assess protein level cell divis control protein cdc p dpscexo huvec subject dpscexosinduc angiogenesi sb p mitogenactiv protein kinas mapk signal pathway inhibitor employ verifi role p mapk pathway vitro vivo histolog immunohistochem stain reveal dpscexo acceler wound heal promot neovascular dpscexo promot migrat prolifer capillari format capac huvec proteom data demonstr protein contain dpscexo regul vasculatur develop angiogenesi pathway analysi reveal protein express dpscexo involv sever pathway includ mapk pathway western blot analysi demonstr dpscexo increas protein level cdc phosphoryl p huvec sb suppress angiogenesi induc dpscexo whole present studi demonstr dpscexo acceler cutan wound heal enhanc angiogen properti huvec via cdcp mapk signal pathway
D055354;D048308
T026;T126;T116
36,321,792
microrna profil paediatr aml flt itd mll rearrang express signatur vitro modul mir p mir p brdhat inhibitor novel therapeut strategi need paediatr patient affect acut myeloid leukaemia aml particular high risk relaps microrna mir extens studi biomark cancer haematolog disord express correl presenc recurr molecular abnorm express oncogen well prognosisclin outcom present studi express signatur differ mir relat presenc myeloidlymphoid mix lineag leukaemia fms like tyrosin kinas intern tandem duplic rearrang clinic outcom paediatr patient aml identifi notabl mir p mir p result possibl relaps risk relat mir thus mir p mir p express modul investig use bromodomaincontain protein brd inhibitor jq natur compound act histon acetyl transferas inhibitor curcumin alon associ order decreas acetyl histon tail potenti effect brd inhibit jq modul mir p mir p express aml synerg effect associ curcumin moreov chang observ express cdknb known target mir p mir p increas apoptosi downregul mir p mir p express cd aml primari cell altogeth find suggest sever mir express signatur diagnosi may use risk stratif relaps predict biomark paediatr aml outlin epigenet drug could repres novel therapeut strategi high risk paediatr patient aml epigenet drug addit research enhanc activ bioavail safeti need
D003474;D015470;D035683
T121;T123;T109;T191;T114;T130
36,321,791
realgarinduc kras mutat lung cancer cell death via krasrafmapk mediat ferroptosi kras biomark nonsmal cell lung cancertarget therapi current effect krastarget medic realgar impel anticanc drug howev signific kras mutant lung cancer uncertain accord find ic h kras mutant cell time lower h nonkra mutant cell flow cytometri hoechst stain assay reveal h cell treat gml realgar apoptot rate h cell rate accord realgar sensit kras mutant cell transcriptom sequenc test indic differ express gene h cell treat realgar h cell treat realgar mitochondria shrank inner membran fold disturb mitochondri membran potenti crush realgar boost intracellular fe reactiv oxygen speci malondialdehyd glutathion level revers ferroptosi inhibitor fer realgar decreas phosphoryl praf perk increas pp pjnk wherea praf abolish fer raf inhibitor sorafenib acceler realgarinduc ferroptosi h cell treat realgar express gpx scla decreas acsl express increas effect could also amplifi sorafenib conclus present studi indic realgar may induc ferroptosi regul raf henc play role antikra mutant lung cancer
D008175;D002289;D000079403
T191;T043
36,321,790
timedepend chang nlrp nrf level lipopolysaccharideinduc acut lung injuri acut lung injuri ali acut respiratori distress syndrom ard sever clinic condit high mortal rate nucleotidebind oligomer domain nod like receptor contain pyrin domain nlrp nuclear factor erel factor nrf report associ ali howev dynam chang level factor lipopolysaccharid lps induc lung injuri remain unclear thus present studi aim determin lpsinduc activ immunolog cascad well nlrpnrf signal pathway differ stage lung injuri purpos mice divid six group follow control lps h lps h lps h lps h lps h group lps mgkg administ intratrach induc lung injuri flow cytometri use determin chang macrophag neutrophil tcell subset lung tissu hematoxylin eosin stain use measur histopatholog chang lung tissu elisa perform evalu level cytokin western blot analysi use measur level inflammatori protein revers transcriptionquantit pcr use determin mrna level target gene follow lps administr evid histopatholog damag neutrophil infiltr observ peak h level interleukin keratinocytederiv chemokin macrophag inflammatori protein tumor necrosi factor mark increas bronchoalveolar lavag fluid serum mice level peak h moreov lps promot toll like receptor express reactiv oxygen speci product thus activ nlrpnrf signal pyroptosi collect present studi demonstr lps trigger multipl inflammatori molecul immun cell ali may close involv irregular redox status nlrpnrf pathway pyroptosi
D008070;D055371
T037;T109
36,321,789
serum brd autoantibodi hepatocellular carcinoma detect use mimotop peptideconjug bsa tumorassoci ta autoantibodi consid promis biomark earli detect cancer prior develop clinic symptom present studi novel ta autoantibodi detect may prove use diagnost marker human hcc use hbxtransgen hbxtg hepatocellular carcinoma hcc mous model target antigen identifi bromodomaincontain protein brd transcript regul play pivot role transcript control divers gene brd upregul hcc tissu hrasvtg mous human subject demonstr use western blot immunohistochem analysi brd autoantibodi addit truncat brd reactiv brd autoantibodi detect tumor cellderiv exosom possibl activ ta immun respons generat autoantibodi detect serum brd autoantibodi epitop mimicri autoantigen brd screen random cyclic peptid cxc librari brd autoantibodi mimotop sequenc ctsvflphc cycliz one pair cystein residu exhibit high affin brd autoantibodi competit inhibit bind autoantibodi cellular brd antigen use cyclic peptid captur antigen human serum enzymelink immunosorb assay allow distinct patient hcc healthi subject sensit specif area roc curv superior serum alphafetoprotein afp sensit specif area roc curv diagnosi hcc addit detect brd autoantibodi combin autoantibodi biomark afp increas accuraci hcc diagnosi suggest combin detect cancer biomark includ brd autoantibodi promis assay hcc diagnosi
D006528;D008113
T191
36,321,786
dedifferenti vivo reprogram commit cell wound repair review accumul evid shown cell dedifferenti reprogram pivot procedur anim deal injuri promot endogen tissu repair tissu damag critic factor trigger cell dedifferenti reprogram vivo contrast microenvironment chang includ loss stem cell hypoxia cell senesc inflamm immun caus tissu damag return cell unstabl state wound persist longterm due chronic damag dedifferenti reprogram surround cell may lead carcinogenesi recent year extens research perform investig cell dedifferenti reprogram vivo signific implic wound repair treatment prevent cancer futur current review summar molecular event known drive cell dedifferenti direct follow tissu injuri effect epigenet modif dedifferenti reprogram vivo addit present review explor intracellular mechan endogen tissu repair relationship cancer essenti balanc risk tissu repair malign transform injuri
D065150;D009369
T062;T191;T043
36,321,783
dexmedetomidin attenu airway inflamm oxid stress asthma via nrf signal pathway allerg asthma chronic inflammatori diseas oxid stress serv pivot role clinic practic dexmedetomidin dex adrenerg receptor agonist use sedat dex exhibit antioxid organprotect properti murin model asthma dex therapeut effect via toll like receptor nfb signal pathway howev whether dex exert antioxid effect asthma yet elucid present studi helper th domin murin asthma model establish dex treatment signific reduc eosinophil airway inflamm mucus overproduct airway hyperrespons well concentr th cytokin lung tissu mice asthma character redox imbal increas oxid stress impair antioxid capac dex treatment allevi imbal decreas level malondialdehyd reactiv oxygen speci increas level glutathion furthermor nuclear factor erythroid relat factor nrf signal pathway inhibit lung tissu asthmat mice effect note downstream gene heme oxygenas glutathion peroxidas mice asthma dex treatment induc express antioxid gene activ nrf wherea ml inhibitor nrf partial abrog antioxid therapeut effect dex best knowledg present studi first demonstr protect effect dex thdomin asthma activ nrf signal pathway result suggest antioxid properti dex could benefici clinic applic dex relief asthmat symptom
D020927;D001249
T121;T047;T109
36,321,778
recent advanc postop pulmonari rehabilit patient nonsmal cell lung cancer review nonsmal cell lung cancer nsclc account lung cancer case high morbid mortal rate past decad treatment strategi nsclc progress rapid particular increas use screen program lead improv initi diagnosi treatment earlystag preinvas tumor surgic intervent remain primari treatment earlystag nsclc thoracoscop lobectomi becom main treatment earlystag nsclc result less postop bleed pain fewer complic howev complic rate thoracoscop lobectomi due sputum retent weaken respiratori muscl strength remain high treat nsclc remain challeng term postop pulmonari rehabilit present review recent advanc postop pulmonari rehabilit patient nsclc present order assist research develop improv treatment enhanc postop pulmonari rehabilit patient
D002289;D008175
T191
36,321,775
kidney vhl diseas earli clear cell prolifer occur distal tubular system renal clear cell carcinoma common occur patient von hippellindau diseas vhl kidney vhl diseas patient vhl kidney contain abund independ clear cell prolifer event hypothes repres precursor structur clear cell carcinoma present studi tri identifi site origin clear cell prolifer immunophenotyp clear cell use histolog track topograph origin microscop clear cell prolifer investig identif inform structur interest immunohistochem stain cluster differenti cd cytokeratin ck consecut serial section addit cdck immunophenotyp prolifer clear cell evalu clear cell prolifer uniform occur distal tubular system clear cell prolifer howev reveal proxim tubul immunophenotyp conclud earli prolifer vhldefici clear cell occur distal tubular system despit associ distal tubular system immunohistochem profil earli clear cell prolifer may inconsist distal tubular origin
D007680;D002292;D006623
T047;T191
36,321,774
rna methyl regul endometri cancer review one three major malign tumor type femal reproduct system endometri cancer ec preval gynecolog cancer develop countri recent year incid ec increas worldwid threaten health wellb women recent research indic express multipl nmethyladenosin regul downregul ec abnorm methyl express associ regul critic pathogenesi progress ec abund intern modif mrna sever studi demonstr close associ develop progress malign tumor epigenet phenomenon methyl present studi current status research methyl ec review mechan methyltransferas demethylas bind protein regul develop progress ec modifi mrna introduc relat research result provid novel method approach prevent treatment ec
D000241;D016889
T123;T121;T109;T191;T114
36,321,766
major shift outpati cirrhosi care deliveri attribut covid pandem nation cohort studi coronavirus diseas covid pandem disrupt health care deliveri unit state increas relianc telemedicin visit oppos person outpati appoint use nation data evalu shift mode hepatolog outpati care patient cirrhosi pandem retrospect cohort studi among us veteran cirrhosi use linear regress evalu absolut percentag chang baselin hepatolog person visit telemedicin visit januari august proport person telemedicin visit plot geograph demonstr state level shift care deliveri time patient level characterist pre covid covid period also compar identifi person telemedicin hepatolog visit among patient cirrhosi person visit signific declin per week confid interv ci p telemedicin visit signific increas per week ci p earli covid period us state level found near state experienc signific shift toward telemedicin cours sever week patient age year black patient less like receiv telemedicin visit pre covid period p although differ elimin covid period conclus among patient cirrhosi hepatolog outpati care deliveri shift heavili toward telemedicin due covid occur across unit state chang sustain august expand telemedicin visit among older patient black patient may reflect dedic effort increas access care among group
D000086382;D017216
T047;T058;T067
36,321,757
share etiolog type diabet hashimoto thyroid popul base twin studi type diabet hashimoto thyroid frequent cluster individu famili indic share origin object studi investig famili co aggreg diseas quantifi share genet environment factor
D003922;D050031;D001327
T047
36,321,689
defin optimum strategi identifi adult children coeliac diseas systemat review econom model coeliac diseas autoimmun disord trigger ingest gluten affect approxim uk popul one three peopl thought diagnosi untreat coeliac diseas may lead malnutrit anaemia osteoporosi lymphoma
D002446;D012878;D010024
T047;T191
36,321,666
valproic acid induc select apoptosi ocular fibrous tunic mice fetus valproic acid vpa prescrib drug common use various neurolog perturb implic teratogen inflict develop fetus pregnanc purpos research delin gross morpholog histolog effect vpa develop eye tunic len
D014635;D064793
T121;T046;T109
36,321,654
calcium inhibit penetr alzheim monom membran calcium ion regul play crucial role maintain neuron function neurotransmitt releas synapt plastic copper cu coordin amyloid acceler aggreg trigger calcium dysregul enhanc influx calcium ion extens perturb integr membran aggreg calcium dysregul membran damag alzheim diseas ad implic gain detail calcium ion role full length cu monom contact cellular membran aggreg elucid neurotox mechan carri extens molecular dynam simul md rigor explor intrigu featur cu interact dimyristoylphosphatidylcholin dmpc bilay presenc calcium ion outcom result compar simul without calcium ion surpris note robust bind energi membran observ simul contain without calcium ion two half fold lesser simul calcium ion therefor case absenc calcium ion n termin residu deepli penetr surfac center bilay contrast calcium ion presenc n c termin residu involv surfac contact bind phosphat moieti hand cu activ particip surfac bilay contact absenc calcium ion contact prevent form calcium bridg cu dmpc bilay case calcium ion presenc nutshel calcium ion allow penetr membran contact cu membran piec inform impli calcium ion mediat membran perturb via monom interact damag membran agre western blot experiment result higher concentr calcium ion inhibit membran pore format peptid
D000544
T047;T048
36,321,623
odontogen keratocyst misdiagnos later periodont cyst clinic radiograph find similar later periodont cyst lpc odontogen keratocyst ok two osteolyt lesion jaw differ local invas percentag recurr aim studi highlight attent differenti diagnosi lesion sometim unexpect locat lead doubt diagnosi therapi follow year old man present depart complaint soft pain vestibular aspect left mandibular second premolar left mandibular first molar vital teeth left mandibl mucos swell drainag observ cbct show well circumscrib hypodens area extend apex mesial root displac resorpt root notifi upon clinic radiograph examin provision diagnosi lpc made enucl lesion histolog examin plan histolog cystic wall partial line keratin squamous epithelium observ surround within lesion chronic inflammatori infiltr also granulomat type cholesterol cleft base find diagnosi odontogen keratocyst done radioluc lesion premolar canin region frequent clinic radiograph misdiagnos identif keratocyst locat preoper favor later periodont cyst suspect biopsi must consid case establish natur lesion best surgic treatment follow appoint
D010509;D009807
T047;T020
36,321,622
syndrom children obstruct sleep apnea obstruct sleep apnea syndrom osa complex disord signific clinic consequ peopl syndrom ds osa frequent seen individu ds present tend sever individu without syndrom
D004314;D020181
T047
36,321,621
elastodont treatment oral bio activ young children elastodont therapi correct bad oral habit malocclus young patient guid jaw growth elimin function disord improv tooth posit aim studi assess effect bio activ therapi presenc atyp swallow tongu thrust grow patient
D008310
T033;T078;T190
36,321,620
soft drink dental eros pediatr age clinic investig dental eros irrevers condit loss teeth hard tissu caus intrins extrins acid attack without bacteri involv common soft drink acid ph releas hydrogen ion act chelat agent dissolv teeth miner compon aim studi investig correl consumpt soft drink children degre dental eros
D014077
T047
36,321,553
opportun pharmacogenet test patient sickl cell anemia background patient sickl cell diseas scd expos numer drug lifespan mani drug clinic pharmacogenet implement consortium cpic guidelin person dose author aim ascertain number drug cpic guidelin prescrib scd patient materi method search indiana univers health affili hospit electron medic record identifi patient diagnosi scd drug drug class cpic action guidelin order inpati outpati prescript collect scd patient result year period patient receiv least one drug could dose accord cpic guidelin conclus preemptiv pharmacogenet test consid scd patient order util data throughout patient life
D010597;D000755
T047;T091
36,321,552
function analysi cancer cell line reveal conserv intrins metabol program cancer cell reprogram metabol support growth invas previous work highlight singl alter reaction pathway drive tumorigenesi remain unclear individu chang propag network level eventu determin global metabol activ character metabol lifestyl cancer cell across pathway genotyp profil intracellular metabolom pan cancer cell line grown ident condit cell line estim activ pathway span entireti metabol network upon cluster discov converg two major metabol type function confirm c flux analysi lipidom analysi sensit perturb reveal major differ cancer associ lipid tca cycl carbohydr metabol thorough integr type multiom highlight littl associ genet alter strong associ marker epitheli mesenchym transit analysi indic absenc variat impos microenviron cancer cell adopt distinct metabol program serv vulner therapi
D055432;D009369
T191;T091
36,321,551
heterogen cancer cell line metabol landscap unravel complex cellular metabol infanc cancer associ genet alter may result chang cellular metabol aid understand phenotyp chang reveal detect metabol signatur elucid vulner particular drug understand cancer associ metabol transform perform untarget metabolit analysi differ cancer cell line differ tissu constant condit differ speci use mass spectrometri ms correl known cancer associ mutat gene express program metabol signatur generat novel associ known metabol pathway known cancer driver show metabol activ correl drug sensit use metabol activ predict drug respons synergi final studi metabol heterogen cancer mutat across tissu find gene exhibit rang context specif general metabol control
D055432;D009369
T191;T091
36,321,549
splicejac transit gene state specif gene regul singl cell transcriptom data extract dynam inform singl cell transcriptom novel task promis advanc understand cell state transit interact gene yet theori orient bottom approach consid differ among cell state larg lack present splicejac method quantifi multivari mrna splice singl cell rna sequenc scrna seq splicejac util unsplic splice mrna count matric construct cell state specif gene gene regulatori interact appli stabil analysi predict putat driver gene critic transit cell state appli splicejac biolog system includ pancrea endothelium develop epitheli mesenchym transit emt lung cancer cell predict gene serv specif signal role differ cell state recov import differenti express gene agreement pre exist analysi predict new transit gene either exclus share differ cell state transit
D059467;D058750
T081;T043;T086
36,321,523
earli stage lung cancer associ higher frequenc chest x ray three year prior diagnosi symptom awar campaign contribut improv earli detect lung cancer previous research suggest may achiev part diagnos lung cancer experienc symptom cancer studi aim explor relationship frequenc chest x ray three year prior diagnosi stage diagnosi
D008168;D008175
T023;T191
36,321,510
state mind adolesc barcelona provinc spain evolut associ factor impact pandem analys evolut state mind adolesc provinc barcelona last six year specif impact pandem experi likewis analys associ factor pre pandem period
D058873;D000086382
T047;T067
36,321,501
assess month cours oral alendron adult avascular necrosi hip manti rct intern pilot peopl avascular necrosi hip limit treatment option current avail stop progress diseas often result need hip replac weak evid class drug call bisphosphon may delay cours diseas trial commiss set provid robust evid regard use bisphosphon adult age year condit
D019386;D013673
T121;T058;T109
36,321,497
intergener genotyp interact drive collect behaviour cycl social insect mani social anim display collect activ cycl base synchron behaviour oscil across group member classic exampl coloni cycl armi ant thousand individu undergo stereotyp biphas behaviour cycl one month cycl phase coincid brood development stage regul cycl otherwis poor understood probe regul cycl durat interact brood worker experiment amen armi ant relat clonal raider ant first establish cycl length vari across clonal lineag use long term monitor data investig putat sourc impact variat cross foster experi four lineag combin development morpholog autom behaviour track analys show cycl length variat stem variat durat larval development stage stage prolong clonal lineag brood direct genet effect also worker indirect genet effect find similar indirect effect worker line brood adult size convers surpris indirect genet effect brood worker behaviour walk speed time spent nest
D001000
T204
36,321,496
sever inbreed increas mutat load gene loss function critic endang devil hole pupfish small popul limit rang often threaten inbreed reduc genet divers reduc fit exacerb popul declin one extrem natur exampl devil hole pupfish cyprinodon diaboli icon critic endang speci smallest known rang vertebr speci experienc sever declin popul size last year suffer major bottleneck popul shrunk individu respect analys resequenc genom desert pupfish death valley ash meadow surround area examin genom consequ small popul size found extrem high level inbreed f roh increas amount potenti deleteri genet variat devil hole pupfish compar speci includ uniqu fix loss function allel delet gene associ sperm motil hypoxia addit success resequenc formalin fix museum specimen found popul alreadi high inbr prior recent known bottleneck thus document sever inbreed increas mutat load devil hole pupfish identifi candid deleteri variant inform manag conserv icon
D007178;D007695
T040;T013
36,321,495
brain stimul reveal distinct motiv under reciproc punish reward reciproc fair form punish reward core human societ order under neural mechan howev fulli understood system suggest evid regard involv right dorsolater prefront cortex rdlpfc medial prefront cortex mpfc reciproc fair three cognit mechan cognit control domain general self refer test provid novel insight comprehens behaviour experi non invas brain stimul particip punish greedi action reward generous action brain stimul either brain area decreas reward punish reciproc cost unexpect increas reward non cost none hypothes mechan fulli account observ behaviour asymmetr involv investig brain area punish reward suggest differ psycholog mechan under punish selfish reward generos propos reciproc punish rdlpfc mpfc process self relev inform term person cost person involv reciproc reward brain region involv control selfish pure reciproc motiv simultan promot enforc fair norm insight bear import endeavour build biolog plausibl model human behaviour
D011678;D012201
T078;T041
36,321,493
first experiment evid activ farm ambrosia beetl strong hered garden microbiom fungal cultiv defin featur advanc agricultur fungus farm ant termit third suppos fungus farm group wood colon ambrosia beetl experiment proof effect beetl activ select promot food fungi other lack farm assum base observ social hygien behaviour experiment remov mother offspr young nest fruit tree pinhol borer xyleborinus saxesenii amplicon sequenc bacteri fungal communiti nest without beetl could show beetl inde abl activ shift symbiont communiti although consum raffaelea food fungi abund beetl present weed fungus chaetomium sp well overal bacteri divers reduc comparison nest without beetl core symbiont communiti general low divers strong sign vertic transmiss cultivar also secondari symbiont find verifi exist activ farm even though exact mechan under select promot andor suppress symbiont need investig
D001517;D048889;D040941;D064307
T032;T044;T204;T028;T001
36,321,492
except soft tissu preserv reveal cnidarian affin cambrian phosphat tubicol enigma exoskelet dwell tube widespread among extant anim earli fossil assemblag except fossil cambrian reveal independ origin tube dwell sever clade includ cnidarian lophophor annelid scalidophoran panarthropod ambulacrarian howev fossil tube lack preserv soft part make difficult understand affin evolutionari signific gangtoucunia aspera wulongq format cambrian stage annul gradual expand phosphat tube occasion attach multipl smaller juvenil previous interpret dwell tube worm eg scalidophoran lophophor problematicum report first soft tissu gangtoucunia reveal smooth bodi circumor tentacl blind spacious gut partit septa consist cnidarian polyp phylogenet analysi resolv gangtoucunia total group medusozoan tube gangtoucunia phenotyp similar problemat annul tubular fossil eg sphenothallus byronia hyolithelminth compar cnidarian annelid among oldest assemblag skelet fossil cnidarian charact g aspera suggest earli tubular taxa best interpret cnidarian rather sessil bilaterian absenc contrari soft tissu evid
D003063
T204
36,321,491
scaveng realm sens smell vision drive recruit carcass neotrop ecosystem social inform acquir observ individu especi relev among speci belong guild unpredict ephemer natur carrion impli social mechan may select among scaveng speci facilit carcass locat consumpt appli surviv model strategi data obtain placement monitor carcass field analys possibl inform transmiss cascad within neotrop scaveng communiti studi highlight use differ sens smell sight within guild facilit carcass locat transmiss social inform speci differ carrion forag effici vultur high develop sens smell play key role process first arriv carcass presenc seem serv visual cue speci locat resourc studi support local enhanc hypothesi within scaveng wherebi individu locat carcass follow forag heterospecif also suggest import sens smell mainten communiti structur
D012903;D046093
T040;T012