PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,323,207
|
hydrotherm liquefact sewag sludg biocrud effect aqueous phase recycl energi recoveri pollut mitig hydrotherm liquefact htl sewag sludg face challeng low biocrud yield larg number intract aqueous phase heavi metal pollut studi aqueous phase produc htl recycl solvent aim improv biocrud yield mitig potenti pollut result show recycl aqueous phase increas biocrud yield energi recoveri ratio recycl could increas content zn cu pb cr solid residu time worth emphas recycl reduc cod aqueous phase howev enhanc protein hydrolysi process reduc calorif valu biocrud mjkg promot migrat nitrogen aqueous phase environment favour direct usag diesel engin analysi show keton phenol aqueous phase particip htl process reactant acid promot hydrolysi protein sludg overal recycl aqueous phase effect improv energi recoveri allevi pollut sludg htl
|
D012722;D014867
|
T121;T197;T069
|
36,323,206
|
print solar evapor seashel ornament inspir structur zero liquid discharg desalin solar driven interfaci evapor enorm promis fresh water recoveri salt harvest salt accumul relat challeng stand way herein report spine groov ridg pair inspir shell ornament vasticardium vertebratum address salt accumul art integr salt reflux local salt crystal seashel mimet radial v groov array enabl evapor transport water rapid direct result high perform water evapor effici local crystal period spine enlighten spine bear ridg seashel provid consider micro unit salt reflux integr design endow three dimension evapor superior solar driven zero liquid discharg excel long term salt resist even deal high salin brine wt nacl seri heavi metal salt solut design offer new altern solut avoid salt scale could advanc local crystal solar evapor toward practic applic
|
D018508
|
T052;T057
|
36,323,205
|
bionic solar driven interfaci evapor system phototherm photocatalyt hydrogel voc remov solar distil solar driven interfaci evapor breakthrough water treatment method harvest solar energi produc clean water howev evapor volatil organ compound voc distil water greatest barrier technolog herein bionic solar driven interfaci evapor system integr phototherm photocatalysi technolog develop base new combin materi tio ti c c n pva ttcp hydrogel evapor phenol contamin water especi actual water seawat lake water reclaim water use evalu water evapor voc photocatalyt degrad perform result show evapor rate ttcp hydrogel kg h kw remov effici phenol rang differ concentr mgl sourc water particular capac bionic evapor first evalu differ type actual water despit initi toc mgl total dissolv solid tds mgl seawat lake water reclaim water differ tds decreas two order magnitud us epa drink water standard mgl maximum toc remov effici reach simul sunlight kw compar effici ultrafiltr techniqu previous report except seawat furthermor real sunlight averag solar irradi kw use assess practic bionic evapor produc kg h vapor reclaim water run steadili effici tds toc remov reach respect technolog small decentr water treatment method good choic remot grid area
|
D057168;D055549
|
T059;T109
|
36,323,204
|
microbi fingerprint methan hybrid electr biolog anaerob digest biomethan sustain altern carbon neutral renew energi sourc fossil fuel high need allevi global energi crisi climat chang convent anaerob digest ad process biomethan product wast water stream wide employ struggl low product rate low bioga qualiti frequent instabl electr biolog hybrid microbi electrochem anaerob digest system mec ad prospect stabl robust biomethan generat facilit complex organ substrat degrad mediat function microbi popul give small input power common voltag v main enhanc communic electroact microorgan electro methanogen despit numer bioreactor test studi conduct base mec ad system integr microbi fingerprint cooper acceler substrat degrad biomethan product fulli summar herein present comprehens review novel develop biotechnolog begin principl mec ad first examin fundament configur classif influenti factor whole system perform reactor type appli voltag temperatur conduct materi etc second extracellular electron transfer either divers microb microb electrod enhanc biomethan product analyz third conclud electro methanogenesi microbi interact construct ecolog network microbi consortia mec ad final futur develop perspect mec ad biomethan product propos
|
D008697;D019149
|
T074;T109
|
36,323,203
|
ecosystem complex explain scale depend ammonia toxic macroinvertebr toxic effect union ammonia nh aquat organ receiv increas attent due excess nitrogen discharg various surfac water research suggest scale depend nh toxic lower field lab condit scale depend toxic big challeng water qualiti criteria set result sole lab test might appli natur ecosystem therefor necessari explor under mechan understand differ toxic across various spatial scale studi use wide distribut gastropod bellamya aeruginosa test anim perform two h microcosm experi experi includ control ammonia addit treatment n lc n lc n lc n lc h lc mg nh nl h lc mg nh nl besid water three potenti key compon food sediment submers macrophyt includ various treatment mimic differ complex level aquat ecosystem water water food water sediment water sediment macrophyt result show food direct improv surviv growth gastropod expect lethal concentr ammonia h concentr nh n lc h acut test sediment macrophyt quick decreas ammonia concentr main sediment adsorpt macrophyt uptak allevi ammonia stress gastropod permit surviv grow expect lethal concentr ammonia h concentr nh n lc lc h acut test sediment macrophyt also provid addit food gastropod extrem high ammonia stress ie h lc food left uneaten macrophyt die gastropod could therefor releas ammonia stress result demonstr moder ammonia stress introduct extra ecosystem element food sediment macrophyt signific improv surviv growth gastropod main enhanc toler quick decreas nh concentr thus toxic howev introduc element littl effect high concentr ammonia ie h lc find add understand reason behind previous observ scale depend toxic nh aquat organ contribut better decis role nh relat water qualiti manag
|
D017753;D014874
|
T131;T070;T082
|
36,323,202
|
calcium enhanc polyhydroxyalkano product promot select growth polyhydroxyalkano store biomass municip activ sludg activ sludg municip wastewat treatment process use direct product biodegrad polyest famili polyhydroxyalkano phas howev municip activ sludg typic accumul phas high level often low yield polym produc substrat observ present work found presenc calcium promot select growth enrich pha store biomass fraction signific improv pha content yield calcium addit result pha content gphagvss averag pha yield substrat gcod pha gcod hac compar gphagvss gcod pha gcod hac without calcium addit h three time pha produc compar control experi without calcium addit higher pha content select biomass product propos consequ calcium depend increas level passiv acet uptak effici substrat uptak could relat format calcium acet complex find lead bioprocess method stimul short term select growth pha store microorgan enabl improv techno econom feasibl municip wast activ sludg becom generic resourc industri scale pha product
|
D054813;D018508
|
T057;T052;T109
|
36,323,201
|
neglect effect polysaccharid transform sludg humif anaerob digest thermal hydrolysi pretreat humus accumul sludg stabil attract increas attent land use potenti studi investig effect thermal hydrolysi pretreat thp sludg humif relat regulatori mechan anaerob digest ad sludg subject ad thp c exhibit higher total extract carbon tec humic acid carbon hac concentr unpretr sludg respect sludg subject ad thp c exhibit lower concentr humif enhanc inhibit respect thp influenc sludg humif ad intracellular polyphenol synthesi extracellular humus condens pathway relat polysaccharid metabol c pretreat sludg exhibit higher polysaccharid avail solubl polysaccharid reduc sugar sampl thus activ intracellular polyphenol metabol ad polyphenol accumul stimul synthesi relat condens enzym polyphenol oxidas quinon oxidoreductas facilit extracellular ha product ad howev thp c result highest product melanoidin co c heterocycl c ch site polysaccharid vs ru nm mlg unpretr sampl heterocycl decreas polysaccharid avail inhibit intracellular polyphenol synthesi consequ inhibit condens enzym suppli extracellular ha product ad overal studi highlight crucial neglect role polysaccharid sludg humif ad avail polysaccharid affect occurr state molecular structur could determin humif regul thp differ temperatur
|
D012722;D059808
|
T121;T069;T109
|
36,323,200
|
press perturb microplast antibiot freshwat micro ecosystem case studi ecolog restor submerg plant microplast mps adsorb antibiot form complex pollut serious threaten health freshwat ecosystem studi examin combin pollut characterist microplast mps antibiot restor freshwat ecosystem effect growth trait aquat primari produc studi ecotoxicolog effect polyethylen pe mps antibiot sulfanilamid sulfa sa structur divers etc function nutrient cycl etc properti water plant sediment ecosystem synergist toxic effect pe sa result reduct chlorophyl content chloroplast fluoresc meanwhil pe sa singlecombin pollut stress inhibit radial oxygen loss root activ antioxid defens system leav chang growth respons characterist vallisneria natan v natan oxid stress induc singlecombin pollut show dosag effect microbi composit over water sediment signific chang pollut exposur evidenc increas microbi divers alter microbi taxa distribut increas total concentr sulfa over water accompani increas relat abund resist gene pe mps signific affect remov total nitrogen antibiot over water interact pe sa affect ammonia nitrit nitrogen exchang water sediment system thus studi investig effect combin mp antibiot pollut growth state metabol function microbi communiti structur microbi divers freshwat ecosystem mechan under combin polyethylen sulfanilamid pe sa effect v natan reveal addit correl differ environment factor analyz structur equat model construct studi provid primari data evalu ecolog environment effect combin pe sa pollut possibl risk moreov provid refer index studi ecolog wetland environ phytoremedi
|
D014874;D031321
|
T131;T002
|
36,323,199
|
binari toxic polystyren nanoplast polybromin diphenyl ether arctic cyanobacteria ambient futur climat cyanobacteria predomin biota arctic interact effect arctic cyanobacteria climat chang shift paramet anthropogen contamin larg unknown util fraction factori experi arctic cyanobacteria pseudanabaena bicep strain pccco captur complex interact climat factor nano polystyren nano ps tetrabromodipenyl ether bde short term binari toxic nano ps bde examin experi toxic unit refer model toxic mechan reveal biochem analys multivari statist found bde nano ps hazard effect chang climat condit mixtur antagonist effect pccco attribut aggreg nano ps adsorpt bde wrap contamin releas extracellular polymer substanc binari toxic caus chain reaction trigger combin individu contamin total protein sensit target posit correl chlorophyl pigment oxid stress mixtur main result presenc nano ps first studi access hazard effect mixtur anthropogen contamin arctic cyanobacteria ambient futur climat
|
D055768;D000458
|
T131;T007;T109
|
36,323,198
|
key role surfac tension transport quantif plastic pollut river current riverin plastic monitor best practic main consid surfac observ thus neglect under distribut plastic water column bias plastic budget estim hinder advanc model predict plastic fate experiment disclos structur plastic transport surfac water flow investig thousand sampl plastic common found fluvial environ travel turbul river flow show first time surfac tension play key role transport plastic sinc effect magnitud buoyanc turbul therefor hold part dispers buoyant plastic captiv water surfac investig two type transport surfac plastic surfac tension turbul buoyanc domin contact free surfac suspend plastic turbul buoyanc domin prove dualiti transport mode major sourc error estim plastic budget underestim follow current well establish monitor protocol sampl conduct sole water surfac base empir find optim physic driven monitor strategi plastic flux river therebi achiev ten fold reduct bias uncertainti riverin plastic pollut estim
|
D010969;D014874
|
T131;T167
|
36,323,173
|
survey afar household water secur emot well reliabl water suppli ethiopian lowland almost half world popul expect experi water stress daili live impact water scarciti physic psychosoci health especi felt arid region ethiopia semi nomad pastoralist popul heavili reliant groundwat domest livestock need howev function water suppli infrastructur reliabl servic deliveri remain challeng cross section water secur household survey head household borehol runtim sensor data afar region ethiopia three main find first higher level household water insecur experi hwise water relat emot distress wred posit correl p lt signific associ limit water servic level non use borehol vulner household demograph femal head household lower household incom lower hwise score associ increas borehol pump usag reliabl cut point h pump usag per day measur electron sensor ad addit water point dri lowland afar led overcrowd rangeland degrad past highlight need balanc increas product human consumpt livestock use come climat resili adapt ensur reliabl alreadi construct top prioriti region govern find suggest increas reliabl daili usag exist water suppli system short sight expans sourc worth invest servic take reach even far flung communiti
|
D014881
|
T081
|
36,322,972
|
cytocompat mg osteosarcoma cell chitosanhydroxyapatitelignin hybrid composit scaffold vitro studi aim fabric promis cytocompat hybrid biocomposit scaffold chitosan cs hydroxyapatit hap lignin l bone tissu engin use freez dri techniqu differ ratio hap l taken determin optimum ratio obtain composit superior properti mechan biolog properti result composit investig mechan result show prepar composit ratio hapl exhibit remark enhanc mechan properti compar other addit found vitro result addit l enhanc water uptak valu result scaffold indic increas hydrophil result signific increas attach prolifer mg cell line osteoblast like cell observ composit scaffold l scaffold without l cshap result could suggest prepar composit scaffold hapl promis biomateri bone tissu engin exhibit better mechan biolog properti prepar composit
|
D048271;D012516
|
T121;T191;T109
|
36,322,950
|
maneuv facilit central venous cathet advanc clavicular region integr review mani situat central venous cathet cvcs insert central peripher venipunctur progress even perform movement shoulder head neck integr review aim verifi scientif evid maneuv facilit advanc cvcs clavicular region andor shoulder adult pediatr neonat patient primari studi avail electron abstract independ idiom public year result show aspect relat descript maneuv cvc advanc clavicular region shoulder includ review sampl includ studi publish cinahl cochran lilac medlinepubm scielo scopus databas maneuv shoulder arm neck head facilit cvc advanc shoulder clavicular region howev studi analyz perform adult research need cvc advanc pediatr neonat popul
|
D062905;D055499;D002405
|
T061;T074;T046
|
36,322,949
|
effect dimension analysi infus medic calcul skill among nurs student intens care unit medic error among common life threaten mistak made health care abil accur calcul drug dose especi intens care unit icus major medic infus reduc medic error research propos dimension analysi improv mathemat calcul drug studi conduct determin effect dimension analysi infus medic calcul skill among nurs student icus quasi experiment studi research sampl consist sixth semest nurs student assign intervent group n control group n intervent group calcul common infus drug icu taught use dimension analysi method wherea control group receiv train without dimension analysi method data collect instrument includ demograph characterist questionnair item questionnair drug calcul measur intervent group data analysi perform use spss mean pretest score infus drug calcul nurs student icu intervent group control group p mean posttest score intervent group control group respect p dimension analysi train signific improv infus medic calcul skill nurs student icu recommend includ method undergradu graduat continu educ nurs cours increas skill calcul infus drug reduc medic error
|
D013338;D004508
|
T065;T097
|
36,322,948
|
peripher intraven cathet insert compet confid medicalsurg nurs object studi implement evid base practic project improv peripher intraven cathet pivc insert confid compet improv first attempt success research use blend onlin learn modul live simul increas pivc insert confid compet intern applic blend curriculum model improv first attempt pivc insert success nurs valid confid assess complet particip n preintervent immedi postintervent day postintervent mann whitney u test determin nurs confid signific higher immedi follow intervent compar preintervent p increas sustain day intervent p place pivc simul observ measur compet use valid tool verifi step requir success rate step nurs self report first attempt pivc success increas signific preintervent survey day postintervent survey p
|
D002406;D000069469
|
T061;T058;T091
|
36,322,947
|
reduct infus time use intraven immunoglobulin formul minut rate escal protocol staf shortag due covid covid pandem chang home infus nurs dramat increas demand home infus nurs decreas avail home infus intraven immunoglobulin ivig option treatment numer condit requir consider infus time use higher concentr ivig product shorter escal increment may decreas requir infus time author conduct retrospect databas analysi identifi patient receiv ivig transit ivig product minut rate escal protocol gammaplex ivig evalu total infus time transit among receiv ivig mean sd ivig dose per dose cycl transit gkg given infus per cycl mean sd time per infus hour transit hour per infus transit infus time decreas transit patient chang patient increas patient nurs educ ivig rate escal may facilit faster achiev maximum safe infus rate reduc infus time trial transit ivig product minut rate escal protocol may also reduc infus time
|
D000086382;D007153
|
T047;T067
|
36,322,918
|
effect time instil therapi outcom cost patient receiv negat pressur wound therapi although npwti associ improv patient outcom compar npwt alon question remain regard time npwti initi
|
D054843
|
T061;T074
|
36,322,917
|
use liquid concentr growth factor manag necrot tissu facial vascular complic induc hyaluron acid inject ha filler may induc facial vascular embol result tissu ischemia necrosi sever iatrogen complic effect treatment avail
|
D000067548;D004617
|
T033;T122;T046
|
36,322,886
|
success upper extrem limb salvag use cellular tissu base product patient uncontrol diabet uncontrol diabet caus dysfunct stage wound heal includ great delay wound closur owe impair angiogenesi ctps play import role advanc wound care especi complex diabet wound categori ctp ecm amniot tissu composit product combin live cell collagen matrix product avail xenograft allograft bioengin product ecm provid biolog scaffold facilit wound heal tend modul wound environ becom incorpor wound bed
|
D023821;D003924
|
T061;T047
|
36,322,885
|
diagnost challeng old diseas covid era report two case carbamazepin induc dress syndrom new mis c develop acut stage covid infect recent report worldwid drug reaction eosinophilia system symptom syndrom rare potenti sever advers drug induc reaction common associ anticonvuls due variabl clinic present involv cutan multiorgan system broad differenti diagnosi lack definit diagnost test diagnosi may delay
|
D063926;D000086382
|
T047;T067
|
36,322,884
|
preval pressur injuri associ factor hospit adult patient cancer hospit cancer patient experi limit daili activ result sever condit chang alter patient sensori percept hinder mobil thus predispos develop pi
|
D009369
|
T191
|
36,322,845
|
earli amino acid extrem preterm infant neurodis year whether higher parenter amino acid intak improv outcom infant extrem low birth weight unclear
|
D000596;D052577;D062071;D065886;D009422
|
T123;T121;T116;T100;T047;T048
|
36,322,844
|
brentuximab vedotin chemotherapi pediatr high risk hodgkin lymphoma adult advanc stage hodgkin lymphoma cd direct antibodi drug conjug brentuximab vedotin combin multiag chemotherapi shown greater efficaci also toxic effect chemotherapi alon efficaci target therapi approach children adolesc hodgkin lymphoma unclear
|
D000971;D000079963;D006689;D000074322
|
T061;T129;T121;T116;T191
|
36,322,843
|
singl dose psilocybin treatment resist episod major depress psilocybin studi use treatment resist depress
|
D000928;D003865;D011562;D061218
|
T121;T109;T048
|
36,322,811
|
giant cell arter elder giant cell arter gca horton diseas segment focal inflamm larg medium size arteri most seen patient year older also peak frequenc individu age howev clinic data scarc age group especi patient
|
D013700;D001025
|
T047
|
36,322,809
|
comparison length stay direct entri emerg admiss acut care geriatr unit hotlin regul develop geriatr care allow direct hospit avoid unnecessari emerg admiss clermont ferrand specif hotlin regul direct entri home emerg geriatr acut care unit aim studi evalu impact entri mode home emerg length stay patient hospit acut care geriatr unit
|
D015277;D005853
|
T090;T058;T091
|
36,322,808
|
oral anticoagul burden oral anticoagul generat burden care affect patient qualiti life concept treatment burden measur impact medic care patient qualiti life various factor exacerb burden sever studi assess satisfact patient treat oral anticoagul
|
D001281
|
T047;T046
|
36,322,807
|
obstacl nurs home depend older adult entri analysi situat result inter establish resid orient commiss decis admit older adult loss autonomi institut complex mani obstacl decis refer institut part explain long hospit stay inadequ health care spend sever obstacl identifi literatur medic complex psycho behaviour disord social vulner etc work base experi aim coordin player inter hospit consult meet dedic decis admit older patient find solut immedi work aim identifi obstacl referr patient hith servic singl centr descript studi analys prospect data collect januari end june averag length hospitalis leav institut relat homogen accord differ complex criteria defin except heavi depend obes situat longer averag length hospitalis absenc complex criteria necessarili associ shorter hospit stay commiss make possibl creat synergi player gerontolog basin facilit admiss complex case hospit
|
D009735;D001523
|
T073;T093;T048
|
36,322,806
|
effect enhanc home support retrospect studi ehpad dom project grow need relat loss autonomi elder peopl opportun imagin altern nurs home context studi aim assess effect reinforc home care model evolut frailti elder peopl whose health condit could justifi enter nurs home
|
D000073496
|
T033;T184;T046
|
36,322,805
|
role social represent embodi situat cognit age exampl transit retir age complex process character physic psycholog social chang interact differ aspect natur explain embodi situat approach cognit offer global integr unifi understand age propos dynam cognit emerg interact sensori motor percept embodi aspect context present situat situat aspect howev studi focus situat aspect cognit studi cognit age yet age also social process associ mani represent often negat effect health cognit stereotyp embodi theori propos represent age intern everyon time gradual modifi intraperson behavior articl propos cognit chang observ age part result physic chang relat repeat behavior chang caus effect represent age howev unlik form stigmat factor belong social group elder neither clear static transit retir seem constitut key stage social age therefor transit retir repres uniqu situat studi impact major social physic context chang cognit function would act catalyst effect represent age mark social transit toward age retir differ perspect appli research also discuss around prevent intervent prepar retir
|
D012179;D000066492
|
T033;T041
|
36,322,804
|
place psychosoci rehabilit psychiatri elder psychosoci rehabilit psr practic focus recoveri person process elder subject work maintain autonomi long possibl remain control life decis belief old person lose abil act often link cognit bias negat impact recoveri inde compar adult elder subject doubli stigmat mental disord consequ age thus geriatr popul requir recoveri process take account specif relat age moreov psr must go beyond control symptom aim improv qualiti life well thus propos describ articl rps tool adapt psychiatri elder subject
|
D000067250;D011570;D001523
|
T061;T091;T097;T058;T048
|
36,322,803
|
optim inform non pharmacolog care therapeut taylor improv wellb qualiti life peopl dementia condit qualiti manag behavior psycholog symptom latter inform non pharmacolog care occupi promin place lack formal make use complex care team propos non systemat review guidelin recommend good profession practic result allow us draw inventori relat strategi collect essenti element taken account develop non medicin intervent appear element concern aspect relat person need ident capac context intervent circumst onset type symptom feasibl intervent propos integr element within clinic reason orient care team toward effect non drug support strategi consider invit research specif characterist differ support strategi question prioriti term train caregiv work popul
|
D011788;D017028
|
T078;T099;T098;T097
|
36,322,802
|
imit meaningless gestur alzheim diseas influenc egocentr allocentr spatial refer frame imit meaningless gestur frequent use task assess praxi skill alzheim diseas ad visuospati analysi consid one cognit mechan involv perceiv gestur ie model imit imit meaningless gestur howev order perform classic gestur imit task ie face model also necessari transpos represent gestur better repres one gestur transposit superimpos dichotomi egocentr spatial refer frame ie self gestur allocentr spatial refer frame ie gestur given previous research relat hippocampus allocentr perform predict ad patient could imit difficulti specif allocentr imit thus propos specif methodolog evalu imit meaningless gestur egocentr allocentr condit use unimanu ie one hand gestur well bimanu ie two hand gestur gest modal condit result show signific differ ad group control group except bimanualallocentr condit moreov correl analys visuospati assess valid essenti role visuospati abil gestur imit task comparison within group result show signific differ egocentr allocentr condit elder control group suggest impact spatial refer frame gestur imit would specif ad howev one also alert within patholog variabl ad would requir futur studi sever subgroup ad patient
|
D005868;D000544
|
T047;T054;T048
|
36,322,801
|
age memori distort impact age stereotyp reliabl memori crucial import extraordinari situat eg court testimoni everyday life eg person must take medic regular basi address issu numer studi document condit fals memori emerg research clear demonstr memori distort normal frequent phenomenon general popul great accentu age review studi document age relat impact memori distort drm misinform paradigm next examin factor underli fals memori suscept focus socio emot factor particular age stereotyp present recent result highlight way negat age relat stereotyp might threaten older adult influenc fals memori suscept import also demonstr older adult memori distort easili reduc take account task characterist particip motiv final discuss implic age relat stereotyp older adult memori evalu theoret appli perspect
|
D013240;D000375
|
T078;T033;T040;T041
|
36,322,800
|
benefit heal garden sleep neurocognit diseas progress neurocognit patholog frequent alter architectur sleep advanc sleep phase phase delay sleep fragment decreas slow wave sleep rem sleep nocturn agit wander even complet revers nycthemer rhythm clear impact health qualiti life patient hospit increas risk sleep disturb due inact sensori depriv daytim hypovigil therapeut garden offer attract sensori stimul set expos natur light possibl adapt physic exercis impact qualiti quantiti sleep cognit behavior unit evalu exploratori manner hypnogram two group patient compar depend whether use garden weather permit summer winter result show patient use garden signific activ day longer nighttim sleep durat less restless night addit patient use walk longer garden benefit increas sleep time view multipl interest therapeut garden meet valid design criteria integr wide establish welcom peopl neurocognit diseas
|
D011788;D012893
|
T078;T047;T048
|
36,322,799
|
wii older adult dementia caregiv think current depend old peopl cognit disord nurs home difficulti even disabl daili life activ wash dress eat orient repres signific workload caregiv non drug approach wide field action impact resid well environ exampl video game wii mani advantag low cost easi use various game posit cognit motor social psycholog effect
|
D018910;D003704
|
T073;T048
|
36,322,798
|
represent age around world influenc cultur covid pandem articl provid synthesi represent age around world popul elder increas year year support elder peopl becom major challeng understand represent age essenti element catch societi take care elder beyond present influenc cultur variabl represent old age articl also propos highlight impact covid percept inde crisi emphas way senior thought treat ethic question aris
|
D063506;D000086382
|
T047;T067;T054
|
36,322,791
|
communiti level evolutionari process link communiti genet replic interactor theori understand communiti level select use lewontin criteria requir communiti level inherit communiti level herit disciplin communiti ecosystem genet often conflat exist studi show possibl studi impos communiti level inherit product experiment design reason experi provid weak support exist communiti level select natur contrast treat communiti interactor line hull replic interactor framework dawkin idea extend phenotyp provid plausibl empir support model role ecolog communiti evolutionari process
|
D017753;D005075
|
T045;T070;T082
|
36,322,776
|
anti pf antibodi associ diseas sever covid sever covid character prothrombot state associ thrombocytopenia microvascular thrombosi almost invari present lung organ postmortem examin evalu presenc antibodi platelet factor pf polyanion complex use clinic valid immunoassay hospit patient covid moder sever diseas world health organ score patient acut covid visit emerg depart convalesc individu anti pf antibodi detect hospit patient covid irrespect prior heparin treatment mean optic densiti valu sd rang contrast patient hospit sever acut respiratori diseas unrel covid mark lower level antibodi high proport patient covid level three immunoglobulin ig isotyp test igg igm iga simultan elev antibodi level higher male femal patient higher african american hispan white patient anti pf antibodi level correl maximum diseas sever score signific reduct circul platelet count hospit individu convalesc covid antibodi level return near normal valu sera patient covid induc higher level platelet activ sera healthi blood donor result correl level anti pf antibodi result demonstr vast major patient sever covid develop anti pf antibodi may play role clinic complic covid
|
D000086382;D013921
|
T047;T067
|
36,322,773
|
gasdermin n termin fragment act negat feedback system inhibit inflammasom mediat activ caspas inflammatori pathway usual util negat feedback regulatori system prevent tissu damag aris excess inflammatori respons whether negat feedback mechan exist inflammasom activ remain unknown gasdermin gsdmd pyroptosi execution downstream inflammasom signal found gsdmd cleavag caspas util rfwk motif n termin loop inhibit activ caspas downstream inflamm negat feedback manner furthermor rfwk motif base peptid inhibitor inhibit caspas activ downstream substrat gsdmd interleukin cleavag well lipopolysaccharid induc sepsi mice collect find provid demonstr n termin fragment gsdmd negat feedback regul control inflammasom activ detail delin under inhibitori mechan
|
D058847;D047908
|
T123;T116
|
36,322,771
|
coupl depend metabol ultradian rhythm confluent cell ultradian rhythm metabol physiolog describ previous mammal howev under mechan rhythm still elus report discoveri temperatur sensit ultradian rhythm mammalian fibroblast independ cell cycl circadian clock period cultur stabl time vari differ cultur rang h show transient singl cell metabol puls synchron stabl ultradian rhythm across contact cell cultur gap junction mediat coupl coordin rhythm also appar metabol physiolog measur includ plasma membran potenti p intracellular glutamin ketoglutar intracellular adenosin triphosph atp cytosol ph intracellular calcium moreov ultradian rhythm requir extracellular glutamin sever differ ion channel suppress mitochondri atp synthas ketoglutar provid key feedback mechan hypothes cellular coupl metabol feedback use cell balanc energi demand surviv
|
D000071218;D057906
|
T040;T079
|
36,322,770
|
insect inspir asymmetr hing doubl layer membran insect wing deform airfoil deform most achiev complic interact structur compon due complex wing design technic challeng associ test delic wing know littl properti compon determin wing respons flight forc report unusu structur hind wing membran beetl pachnoda marginata structur transvers section claval flexion line consist two distinguish layer bell shape upper layer straight lower layer comput simul show effect one way hing stiff tension upward bend flexibl compress downward bend systemat vari design paramet comput model show properti doubl layer membran hing tune wide rang enabl us develop broad design space later use model select use select model three distinct applic prove doubl layer hing repres simpl yet effect design strategi control mechan respons structur use singl materi extra mass insect inspir one way hing particular use develop structur asymmetr behavior exhibit differ respons load two opposit direct multidisciplinari studi advanc understand biomechan complic insect wing also inform design easili tunabl engin hing
|
D014921;D001517
|
T017;T204
|
36,322,769
|
assess quadrival nucleosid modifi mrna vaccin protect group influenza virus combin vaccin formul target hemagglutinin also influenza virus antigen could form basi univers influenza virus vaccin potenti elicit long last broad cross reactiv immun respons lipid nanoparticl lnp encapsul messeng rna mrna vaccin util effici target multipl antigen singl vaccin assess immunogen protect efficaci nucleosid modifi mrna lnp vaccin contain four influenza group virus antigen hemagglutinin stalk neuraminidas matrix protein nucleoprotein mice found vaccin compon induc antigen specif cellular humor immun respons administr singl dose monoval formul exclus protect combin quadrival formul protect mice challeng virus includ relev hn influenza virus group strain minim weight loss import combin vaccin protect morbid dose ng per antigen singl vaccin mice find confid conclud nucleosid modifi mrna lnp platform use elicit protect larg panel influenza virus
|
D053118;D007252;D009976;D007251
|
T129;T121;T109;T005;T047
|
36,322,767
|
sun regul mitot durat respons extracellular matrix rigid cell adjust growth spatial mechan constraint surround environ central mani aspect biolog examin extracellular matrix ecm rigid affect cell divis found cell divid rapid cultur rigid substrat observ effect ecm rigid round postmitot spread durat found chang matrix stiff impact mitosi progress notic ecm elast regul express linker nucleoskeleton cytoskeleton linc complex compon sun turn promot metaphas anaphas transit act mitot spindl format wherea cell adher soft ecm low level sun express perturb astral microtubul organ delay onset anaphas
|
D015530;D003599
|
T026
|
36,322,766
|
ocean nutrient rise late miocen incept pacif oxygen defici zone modern pacif ocean host largest oxygen defici zone odz oxygen concentr low nitrat use respir organ matter histori odz may offer key insight ocean deoxygen futur global warm record southeastern pacif observ gt increas foraminifera bound nitrogen isotop nn sinc late miocen mya indic larg odz expans coincid chang find major increas nutrient content ocean reconstruct phosphorus iron measur hydrotherm sediment site wherea global warm studi cast seawat oxygen concentr main depend climat ocean circul find indic modern odz underpin histor high concentr seawat phosphat
|
D012623;D056908
|
T204;T167
|
36,322,765
|
phylodynam signatur emerg communiti associ mrsa communiti associ methicillin resist staphylococcus aureus mrsa lineag emerg mani geograph distinct region around world past appli consist phylodynam method across multipl communiti associ mrsa lineag describ contrast pattern emerg dissemin generat whole genom sequenc data australian sequenc type st st mrsa iv remot communiti far north queensland papua new guinea bengal bay st mrsa v clone metropolitan communiti pakistan increas effect reproduct number sustain transmiss gt coincid spread progenitor methicillin suscept aureus mssa remot northern australian popul dissemin st mrsa iv genotyp popul center australian east coast subsequ import highland papua new guinea far north queensland appli phylodynam method exist lineag dataset identifi common signatur epidem growth emerg epidemiolog trajectori communiti associ aureus lineag america asia australasia europ surg observ diverg antibiot resist strain coincid establish region popul center epidem growth also observ among drug resist mssa clade africa northern australia data suggest emerg communiti associ mrsa late th centuri driven combin antibiot resist genotyp host epidemiolog lead abrupt chang lineag wide transmiss dynam sustain transmiss region popul center
|
D055624;D013203;D017714
|
T047;T007
|
36,322,764
|
structur function subsystem model comput lesion central nervous system rostral sector forebrain midbrain craniot central nervous system divid rostral intermedi caudal sector rostral sector contain vertebr forebrain midbrain network scienc tool use creat analyz rat hierarch structur function subsystem model intrarostr sector neural connect gray matter region hierarchi bottom level subsystem three upper level subsystem correspond voluntari behavior control cognit affect instinct surviv behavior homeostasi oculomotor control previous work subsystem identifi base coclassif network communiti reveal function relat carri focal perturb neural structur connect comprehens comput lesion region network result effect network modular subsystem organ systemat map measur pattern chang found correl three structur attribut lesion region region central degre strength between region posit hierarchi subsystem distribut region neural output input expect greater region central result averag stronger lesion impact distribut lesion effect addit analysi suggest strong function relat region belong bottom level subsystem exhibit similar effect lesion similar account coher pattern disturb align subsystem boundari propag network systemat lesion effect similar across function relat region potenti interest theoret experiment clinic studi
|
D016548;D002540
|
T023;T029
|
36,322,763
|
two intrins time mechan set start end time dendrit arbor nocicept neuron choreograph dendrit arbor take place within defin time frame time mechan current known report precis time lin lin regulatori circuit trigger initi dendrit growth activ wherea precis time lin let lin regulatori circuit signal subsequ development declin dendrit growth abil henc restrict dendrit arbor within set time frame loss function mutat lin microrna gene caus limit dendrit outgrowth wherea loss function mutat direct target lin transcript factor gene caus precoci excess outgrowth contrast loss function mutat let microrna gene prevent development declin dendrit growth abil wherea loss function mutat direct target lin tripartit motif protein gene caus declin lin let regulatori circuit express right place right time set start end time dendrit arbor replac lin upstream cis regulatori sequenc lin locus late onset let upstream cis regulatori sequenc delay dendrit arbor wherea replac let upstream cis regulatori sequenc let locus earli onset lin upstream cis regulatori sequenc caus precoci declin dendrit growth abil result indic lin lin lin let lin regulatori circuit control time dendrit arbor antagonist regul dma receptor level dendrit lin transcript factor like direct repress dma gene express transcript mean wherea lin tripartit motif protein like indirect promot dma gene express posttranscript mean
|
D029742;D035683
|
T123;T116;T114
|
36,322,762
|
control resist bacteriophag kill metabol regul mening associ escherichia coli ecolog benefici trait bacteria encod intrins horizont acquir gene howev trait univers high mosaic natur bacteri genom requir control transcript level drive process emerg regulatori flexibl widespread escherichia coli speci wherebi preexist transcript factor acquir new unrel role regul benefici trait dsdc regul serin toler e coli essenti serin catabol often encod two copi neonat mening associ e coli nmec reveal dsdc global regul transcript nmec requir serin control novel benefici trait show dsdc bind chromosom unusu manner mani bind site arrang cluster span entir operon within gene code sequenc neuo import identifi neuo signific regul gene strain delet dsdc copi presenc absenc serin neuo prophag encod sever nmec k isol mediat capsul acetyl effect attach invas human brain endotheli cell instead demonstr neuo provid resist k bacteriophag attack critic function regul dsdc work highlight horizont acquir enzym function cell surfac modul control intrins regul provid key ecolog benefit e coli pathotyp
|
D029968;D001435
|
T005;T116
|
36,322,761
|
nano posit tubulin conform contribut axon transport regul mitochondria along microtubul correct spatiotempor distribut organell vesicl crucial healthi cell function regul intracellular transport mechan control transport bulki mitochondria especi import polar cell neuron reli organell local produc energi buffer calcium mitochondri transport requir depend microtubul fill much avail axon space mitochondri transport affect posit within microtubul bundl known found anterograd transport driven kinesin motor suscept molecular conform tubulin neuron vitro vivo anterograd veloc negat correl densiti elong tubulin dimer like guanosin triphosph gtp tubulin impact tubulin conform depend primarili mitochondrion posit either within rim microtubul bundl increas elong tubulin level lower number motil anterograd mitochondria within microtubul bundl increas anterograd transport speed microtubul bundl rim demonstr increas kinesin veloc densiti microtubul consist elong dimer add increas mitochondri dynam work indic molecular conform tubulin contribut regul mitochondri motil local distribut mitochondria along axon
|
D014404;D001370
|
T123;T116;T043
|
36,322,760
|
origin electrochem driven phase transform oxygen electrod solid oxid cell next generat fuel cell electrolyz batteri requir higher power faster kinet larger energi densiti necessit use composit complex oxid achiev multifunct activ composit complex oxid may chang phase structur electrochem process call electrochem driven phase transform origin phase chang remain obscur aim paper present experiment studi theoret analysi phase evolut praseodymium nickel nickel base electrod show time greater phase transform oper compar thermal anneal one theoret analysi suggest presenc reduc oxygen partial pressur interfac oxygen electrod electrolyt origin phase chang oxygen electrod guid theori addit electron conduct interfac layer lead signific suppress phase chang improv cell perform perform stabil
|
D010087;D011211
|
T197;T073
|
36,322,759
|
omic analys somat trprw breast cancer model identifi cooper driver event activ pikaktmtor signal alter tumor suppressor tp one common event cancer alon insuffici tumor develop serv driver transform sought identifi cooper event genom analys somat trprw mous model equival tprw hot spot mutat human cancer recapitul metastat breast cancer develop identifi cooper lesion similar found human breast cancer moreov identifi activ pikaktmtor pathway tumor via mutat pten erbb kras andor recurr pipkc mutat stabil pipkc protein activ pikaktmtor signal anoth pipkc famili member pipka coamplifi pikb human breast cancer patient encod kinas respons product pik substrat phosphatidylinositol bisphosph thus tprw mutat pikaktmtor signal major cooper event drive breast cancer develop addit combin two us food drug administr fda approv drug tigecyclin metformin target oxid phosphoryl downstream pik signal inhibit tumor cell growth may repurpos breast cancer treatment find advanc understand mutant p drive breast tumor develop pinpoint import pikaktmtor signal expand combin therapi breast cancer treatment
|
D001943;D019869
|
T191;T126;T116
|
36,322,758
|
long term depress induct stimul caus long term potenti mous purkinj cell mutant thyroid hormon receptor thyroid hormon ths regul gene express bind nuclear th receptor trs cell ths indispens brain develop howev littl knowledg congenit hypothyroid neuron affect function central nervous system adulthood report specif th effect function develop cerebellum use transgen mice overexpress domin negat tr mf specif cerebellar purkinj cell pcs adult mf mice display impair motor coordin motor learn surpris long term depress ltd induct stimul caus long term potenti ltp parallel fiber pf pc synaps adult mf mice although abnorm morpholog basal properti pf pc synaps ltp phenotyp turn ltd mf mice induct stimul appli extracellular high ca condit confoc calcium imag reveal dendrit ca elev evok ltd induct stimul signific reduc mf pcs pc depolar singl pc messeng rna quantit analysi show reduc express serca ip receptor type mf pcs essenti mglur mediat intern calcium releas endoplasm reticulum cerebellar pcs abnorm chang observ adult onset pc specif th defici mice creat adeno associ virus vector thus propos import th action neural develop establish proper cerebellar function adulthood independ morpholog present studi give insight cellular molecular mechan under congenit hypothyroid induc dysfunct central nervous system cerebellum
|
D011689;D003409
|
T019;T047;T025
|
36,322,757
|
inhibit connexin hemichannel allevi neuroinflamm hyperexcit tempor lobe epilepsi tempor lobe epilepsi tle one common type epilepsi yet approxim one third patient refractori current anticonvuls drug target neuron synaps astrocyt microgli dysfunct common found epilept foci shown contribut neuroinflamm hyperexcit chronic epilepsi accumul evid point key role glial hemichannel epilepsi inhibit connexin cx gap junction hemichannel lead undesir side effect former coordin physiolog function cell assembl would great benefit use oral avail small molecul block hemichannel allevi epilept symptom explor effect newli develop compound inhibit cx hemichannel cx gap junction use pilocarpin mous model tle vitro applic caus near complet reduct pilocarpin induc cell membran permeabl associ increas cx hemichannel activ moreov preadministr vivo effect reduc neuroinflamm alter synapt inhibit enhanc anim surviv rate posttreat singl dose vivo prolong effect suppress activ astrocyt microglia rescu chang neuroinflammatori synapt gene express induc pilocarpin collect result indic target cx hemichannel effect promis strategi treat epilepsi neuroinflamm play critic role
|
D004833;D004827
|
T033;T047
|
36,322,756
|
structur amorph calcium carbon phase involv format pinctada margaritifera shell mollusc shell form amorph calcium carbon acc compound transform crystallin materi transform mechan fulli understood howev crucial develop bioinspir synthet biominer strategi accur marin biominer proxi geoscienc difficulti aris simultan presenc crystallin amorph compound shell complic select experiment character amorph fraction use nanobeam x ray total scatter togeth approach separ crystallin amorph scatter contribut obtain spatial resolv atom pair distribut function pdf resolv three distinct amorph calcium carbon compound present shell pinctada margaritifera attribut interprismat periostracum young miner unit matur miner unit extract accur bond paramet revers mont carlo rmc model pdf show three amorph compound differ most ca nearest neighbor atom pair distanc character convent spectroscop techniqu unveil presenc mg shell show mg calcit final crystal shell line recent literatur propos amorph crystal transit mediat presenc mg transit occur decomposit initi mg rich precursor second mg poor acc compound form crystal
|
D049911
|
T204
|
36,322,755
|
music infant direct sing entrain infant social visual behavior infant direct sing cultur univers music phenomenon known promot bond infant caregiv entrain wide observ physic phenomenon divers physic system adjust rhythmic activ interact show simpl act infant direct sing entrain infant social visual behavior subsecond timescal increas infant look eye sing caregiv earli month age doubl strength month infant synchron eye look rhythm infant direct sing rhythmic entrain also structur caregiv cue enhanc visual display social communic content caregiv increas wide eye posit affect reduc neutral facial affect reduc eye motion reduc blink time rhythm sing align time moment infant increas eye look addit rhythm infant direct sing experiment disrupt reduc predict infant time lock eye look also disrupt result reveal generic process entrain fundament coupl mechan rhythm infant direct sing attun infant precis time social communic content support social learn develop
|
D009146;D063346
|
T054;T170;T055;T097
|
36,322,754
|
delay effect stabil larg ecosystem common intuit among ecologist midtwentieth centuri larg ecosystem stabl smaller number speci view challeng robert may found stabil bound random assembl ecosystem becom unstabl suffici larg number speci present work show may bound great chang past popul densiti speci affect current densiti common featur real system effect speci interact may appear time lag rather instantan local stabil model self interact describ bound character paramet space find critic delay curv separ region stabil instabl correspond identifi critic frequenc curv provid characterist frequenc system instabl threshold final calcul analyt distribut eigenvalu general wigner well girko law interest find suffici larg delay eigenvalu random coupl system complex even interact symmetr
|
D017753
|
T070;T082
|
36,322,753
|
igfbp promot cancer progress degrad rna transcript encod v atpas subunit igfbp bind number rna transcript suggest function tumor promot although littl known regard mechan regul role rna metabol demonstr igfbp bind untransl region transcript encod atpva catalyt subunit vacuolar atpas v atpas serv substrat nad depend deacetylas sirt regul igfbp affect stabil atpva transcript suffici level sirt express catalyz deacetyl igfbp bind atpva transcript mediat degrad howev sirt express low acetyl form igfbp accumul upon bind atpva transcript recruit xrn nucleas catalyz transcript degrad thus stabil atpva transcript signific compromis breast cancer cell sirt express low knock lead reduct express function v atpas complex cancer cell impair lysosom activ result product cellular secretom consist increas number exosom enrich ubiquitin protein cargo solubl hydrolas includ cathepsin togeth combin promot tumor cell surviv invas find describ previous unrecogn role igfbp mediat degrad messeng rna transcript essenti lysosom function highlight sirtuin regul acetyl state signific biolog diseas consequ
|
D025262;D009369
|
T191;T126;T116
|
36,322,752
|
spatiotempor map temperatur dynam lysosom mitochondria use cascad organell target upconvers nanoparticl intracellular metabol organell like lysosom mitochondria high coordin spatiotempor function activ lysosom enzym signific reli cytoplasm temperatur heat constant releas mitochondria byproduct adenosin triphosph atp generat activ metabol develop temperatur sensit lysodot mitodot monitor situ thermal dynam lysosom mitochondria design base upconvers nanoparticl ucnp high densiti surfac modif achiev except high sensit k low uncertainti k nanothermometri use live cell show measur independ ion concentr ph valu ca ion shock temperatur lysosom mitochondria increas c intrigu chloroquin cq treatment lysosom temperatur observ decreas c mitochondria remain relat stabl last oxid phosphoryl inhibitor treatment observ c temperatur increas thermal transit mitochondria lysosom observ indic differ metabol pathway thermal transit lysosom mitochondria insid hela cell nanothermometri probe provid power tool multimod function imag subcellular organell interact high spatial tempor thermal dynam resolut
|
D008247;D053758
|
T026;T073
|
36,322,751
|
spontan phase coordin fluid pump model ciliari carpet ciliat tissu mammalian lung brain reproduct tract special pump fluid generat flow collect activ hundr thousand individu cilia beat strike metachron wave pattern despit progress analyz cilia coordin general theori link coordin fluid pump limit larg array cilia remain lack conduct silico experi thousand hydrodynam interact cilia develop continuum theori limit infinit mani independ beat cilia combin tool activ matter classic stoke flow find simul theori isotrop synchron ciliari state unstabl travel wave emerg regardless initi condit characterist wave net flow depend cilia tissu properti metachron phase coordin stabl global attractor larg ciliari carpet even finit perturb cilia tissu properti result support notion function specif ciliat tissu interlac tissu architectur cilia beat kinemat open prospect establish structur function map cilium level beat tissu level coordin fluid pump
|
D005430;D002923
|
T026;T073
|
36,322,750
|
initi impress compat mate valu predict later date romant interest romant first impress seem linger studi investig romant desir initi interact predict later relat outcom eg later romant interest contact attempt use design teas apart differ possibl mechan eg mate valu select compat across three speed date studi n longitudin follow up includ colleg communiti sampl sampl men date men investig whether differ compon initi romant impress predict later romant outcom relationship initi use social relat model partit initi desir speed date determin total date partner effect date consensu desir eg mate valu actor effect particip general desir eg select relationship effect particip uniqu like date beyond partner actor effect eg compat predict later evalu romant interest physic attract desir know better behavior direct messag go date meta analys across three studi show across follow report partner relationship effect especi strong predictor relationship initi variabl consist evolutionari model human pair bond find suggest consensu desir trait uniqu impress compat linger effect relationship develop even moment two potenti partner meet
|
D012725;D007398
|
T032;T080;T055;T054;T053
|
36,322,749
|
quantifi narrat flow imagin versus autobiograph stori lifelong experi learn knowledg lead share expect common situat tend unfold knowledg narrat event flow enabl peopl weav togeth stori howev compar comput tool evalu flow event narrat limit quantifi differ autobiograph imagin stori introduc sequenti measur narrat flow event draw probabilist infer cut edg larg languag model gpt sequenti captur flow narrat compar probabl sentenc without preced stori context appli measur studi thousand diari like stori collect crowdwork either recent rememb experi imagin stori topic result show imagin stori higher sequenti autobiograph stori sequenti autobiograph stori increas memori retold sever month later pursuit deeper understand sequenti measur flow narrat explor proport major minor event stori sentenc annot crowdwork find lower sequenti associ higher proport major event method result highlight opportun use cut edg comput analys sequenti larg corpora match imagin autobiograph stori investig influenc memori reason languag generat process
|
D033262;D011939
|
T078;T170;T041
|
36,322,748
|
chromophor hydrolysi releas photoactiv rhodopsin nativ membran sustain vision photoactiv rhodopsin rho must undergo hydrolysi releas tran retin produc substrat visual cycl apo opsin avail regener cis retin kinet hydrolysi yet describ rhodopsin nativ membran environ develop method consist simultan denatur chromophor trap isopropanolborohydrid follow exhaust protein digest complet extract liquid chromatographi mass spectrometri use method track rho hydrolysi subsequ format n retinyliden phosphatidylethanolamin n ret pe adduct releas tran retin reduct tran retin tran retinol found hydrolysi occur faster nativ membran deterg micell typic use studi membran protein activ energi hydrolysi nativ membran determin kcalmol data support interpret metarhodopsin ii signal state rhodopsin primari speci undergo hydrolysi releas tran retin absenc nadph free tran retin react phosphatidylethanolamin pe form substanti amount n ret pe total tran retin physiolog ph rate order magnitud faster rho hydrolysi howev n ret pe format high attenu nadph depend reduct tran retin tran retinol neither n ret pe format tran retin reduct affect rate hydrolysi rho studi provid comprehens pictur hydrolysi rho releas tran retin reentri visual cycl process alter lead sever retinopathi
|
D012243;D012172
|
T123;T121;T116;T127;T109
|
36,322,747
|
generat genom edit chicken duck line adenovirus mediat vivo genom edit convent avian genom edit mediat isol cultur genom edit primordi germ cell pgcs screen propag genom edit pgcs transplant pgcs recipi embryo pgc mediat procedur howev technic difficult therefor convent method previous util chicken generat germlin mosaic founder chicken duck line without pgc mediat procedur inject adenovirus contain crispr cas system avian blastoderm genom edit chicken duck offspr produc founder carri differ insert delet mutat without mutat potenti target site data demonstr success applic adenovirus mediat method product genom edit chicken duck line
|
D000072669;D002645
|
T063;T012
|
36,322,746
|
structur organ deinococcus radioduran cell envelop surfac layer layer high order coat protein local cell surfac mani bacteri speci structur one protein form elementari unit self assembl crystallin monolay tile entir cell surfac cell envelop radiat resist bacterium deinococcus radioduran studi cryo electron microscopi find crystallin regular layer extend layer outer membran periplasm inner membran cell envelop appear high pack result three dimension crystallin distribut protein complex organ close continu yet allow certain degre free space present result suggest layer least speci mesoscal assembl behav structur function scaffold essenti entir cell envelop
|
D034301
|
T007
|
36,322,743
|
polic agenc facebook overreport black suspect larg grow share american public turn facebook news platform report crime increas come direct law enforc agenc rais question content curat gather post almost facebook page maintain us law enforc agenc focus report crime race found facebook user expos post overrepres black suspect percentag point relat local arrest rate overexposur occur across crime type geograph region increas proport republican voter non black resid widespread exposur overreport risk reinforc racial stereotyp crime exacerb punit prefer among politi general
|
D016495;D061108
|
T170;T097
|
36,322,742
|
magnetosom inspir synthesi soft ferrimagnet nanoparticl magnet tumor target magnet target one promis approach improv target effici magnet drug carrier direct use extern magnet field reach target natur magnet nanoparticl mnp biolog origin magnetosom special organell form biominer magnetotact bacteria mtb essenti mtb magnet navig respond geomagnet field magnet target magnetosom howev hinder aggreg precipit magnetosom water biolog fluid environ due strong magnet attract particl studi construct magnetosom like nanoreactor introduc mtb mms protein revers micell system mnps synthes thermal decomposit exhibit crystal morpholog magnet high satur magnet low coerciv natur magnetosom smaller particl size dspe mpeg coat magnetosom like mnps exhibit good monodispers penetr lesion area tumor mous model achiev magnet enrich order magnitud control group demonstr great prospect biomed magnet target applic
|
D055944;D053758;D009369;D042201
|
T026;T191;T073;T007
|
36,322,741
|
ierip critic maintain glucos homeostasi regul endoplasm reticulum function surviv cell recess mutat ierip immedi earli respons interact protein caus syndrom microcephali epilepsi perman neonat diabet med ierip encod endoplasm reticulum er membran protein crucial brain develop howev role ierip cell remain unknown generat two mous model either constitut induc ierip delet cell name ierip ko ierip iko respect found ierip ko caus sever earli onset insulin defici diabet function studi reveal mark dilat cell er along increas proinsulin misfold elev express er chaperon includ pdi ero bip pipk islet transcriptom analysi confirm qrt pcr reveal decreas express gene associ cell matur cell cycl antiapoptot gene accompani increas express antiprolifer gene inde multipl independ approach demonstr ierip ko impair cell matur prolifer along increas condens cell nuclear chromatin induc cell ierip delet adult wk old mice induc similar diabet phenotyp suggest ierip also critic function surviv even cell earli develop import ierip decreas cell patient type diabet td suggest associ ierip defici cell dysfunct common form diabet data uncov critic role ierip cell also provid insight molecular basi diabet caus ierip mutat
|
D003924;D050417
|
T047;T025
|
36,322,740
|
use oatm date tibetan ice core record holocenel glacial climat ice core northwestern tibetan plateau nwtp contain long record region climat variabl refrozen meltwat dust core hamper develop robust timescal introduc approach date ice via isotop composit atmospher air bubbl oatm along annual layer count radiocarbon date provid robust chronolog water isotop record oic excess three ice core guliya ice cap nwtp measur oatm although common polar ice core timescal rare use ice core low latitud high altitud glacier due low air pressur common presenc refrozen melt add dissolv gase reduc amount air avail analysi respiratori consumpt molecular oxygen micro organ ice fraction atmospher valu make correct melt respir address complic result record water isotop guliya ice core reveal climat variat last time correspond observ independ date lake speleothem record confirm guliya ice cap exist holocen millenni scale driver oic complex tempor variabl howev guliya oic valu sinc mid th centuri highest sinc begin holocen increas region air temperatur
|
D046448;D055110
|
T062;T070
|
36,322,739
|
adult neurogenesi act neural regular new neuron continu generat subgranular zone dentat gyrus throughout adulthood new neuron gradual integr hippocamp circuit form new naiv synaps view perspect new neuron may repres signific sourc wire nois hippocamp network machin learn nois inject common use regular techniqu regular techniqu help prevent overfit train data allow model general learn new unseen data use comput model approach ask whether neurogenesi like process similar act regular facilit general categori learn task convolut neural network cnn train cifar object recognit dataset model neurogenesi replacementturnov mechan weight random chosen small subset hidden layer neuron reiniti new valu model learn categor differ class object found neurogenesi enhanc general unseen test data compar network neurogenesi moreov neurogen network either outperform perform similar network convent nois inject ie dropout weight decay neural nois result suggest neurogenesi enhanc general hippocamp learn nois inject expand role neurogenesi may cognit
|
D008568;D055495
|
T040;T041
|
36,322,738
|
embryon microrna essenti bovin preimplant embryo develop microrna mirna small noncod rnas regul gene express transcript mirna present transcript quiescent full grown oocyt preimplant embryo display low level transcript prior embryon genom activ role mirna preimplant develop known tempor pattern express mirna bovin preimplant develop determin small rna sequenc use egg preimplant embryo cell cell cell cell cell morula blastocyst embryo cultur presenc amanitin permit distinguish matern mirna embryon mirna indic embryon mirna express first detect two cell stage dramat increas morula blastocyst stage target dgcr small interf rnamorpholino approach reveal role mirna morula blastocyst transit knockdown dgcr inhibit express embryon express mirna also inhibit morula blastocyst transit addit rna sequenc identifi increas relat abund messeng rnas potenti target embryon mirna dgcr knockdown embryo compar control result experi implic essenti role mirna bovin preimplant embryo develop
|
D035683;D058727
|
T123;T114
|
36,322,736
|
reduc surfac accumul swim bacteria viscoelast polym fluid surfac associ bacteri communiti flourish natur bodi anim host abund macromolecular polym unclear endow viscoelast polymer fluid influenc bacteri motil behavior environ combin experi theori studi near surfac swim flagel bacteria viscoelast polym fluid contrast swim behavior newtonian fluid discov cell swim less curv trajectori display reduc near surfac accumul use theoret analysi non newtonian hydrodynam forc demonstr exist generic lift forc act rotat filament near rigid surfac aris elast tension generat along curv flow streamlin viscoelast lift forc weaken hydrodynam interact flagel swimmer solid surfac contribut decreas surfac accumul find reveal previous unrecogn facet bacteri transport surfac explor polym rich environ pertin divers microbi process may inform design artifici microswimm capabl navig complex geometri
|
D013550;D011108
|
T104;T056;T122
|
36,322,735
|
histon deacetylas transduc heat signal plant cell heat stress limit plant growth develop crop yield plant cell precis sens transduc heat stress signal remain elus identifi conserv heat stress respons mechan elucid heat stress signal transmit cytoplasm nucleus epigenet modifi demonstr histon deacetylas hda transduc heat signal cytoplasm nucleus play posit regulatori role heat respons arabidopsi heat specif induc hda accumul nucleus heat stress phosphatas ppab direct interact dephosphoryl hda protect hda proteasom mediat degrad lead transloc nonphosphoryl hda nucleus heat induc enrich hda nucleus depend nucleoporin hos nucleus hda bind deacetyl target gene relat signal transduct plant develop repress gene express transcript factor yin yang depend independ manner result rebal plant develop heat respons therefor uncov hda mediat posit regulatori modul heat shock signal transduct pathway import cytoplasm nucleus transloc hda respons heat stress conserv wheat rice confer mechan signific implic potenti crop breed cope global climat warm
|
D029681;D017360
|
T116;T002
|
36,322,734
|
dmp regul hapgc traffick time acquisit sperm fusion compet sexual reproduct involv fusion two gamet opposit sex although sperm express fusogen hapless hap generat cell specif gcs play vital role process mani eukaryot organ understand regul emerg unicellular system j zhang et al nat commun j f pinello et al dev cell e neither hapgc interactor mechan deliveri activ fusion site known multicellular plant show arabidopsi thaliana hapgc interact two sperm duf membran protein dmp dmp requir egg cell ec induc transloc hapgc intern storag vesicl sperm plasma membran ensur success fertil studi arabidopsi tobacco provid evid conserv function dmp like protein hapgc partner seed plant data suggest seed plant evolv dmp depend fusogen transloc process achiev time acquisit sperm fusion compet respons egg cell deriv signal reveal previous unknown critic step success fertil
|
D029681;D017360
|
T116;T002
|
36,322,732
|
link global top view first person view brain human anim remark capac translat posit one spatial frame refer anoth abil seamless move top first person view import navig memori format cognit task evid suggest medial tempor lobe cortic region contribut function understand neural system might carri comput use variat autoencod vae reconstruct first person view top view robot simul vice versa mani latent variabl vae similar respons seen neuron record includ locat specif activ head direct tune encod distanc local object place specif respons promin reconstruct first person view top view head direct specif respons promin reconstruct top view first person view case model could recov perturb without retrain rather remap result could advanc understand brain region support viewpoint linkag transform
|
D001921;D013702
|
T023;T029
|
36,322,731
|
combin common mtdna variant result mitochondri dysfunct connect tissu dysregul mitochondri dysfunct associ rang clinic manifest report famili complex phenotyp includ combin connect tissu neurolog metabol symptom pass surviv children analysi matern inherit mtdna reveal novel genotyp encompass haplogroup j defin mitochondri dna mtdna nd mg gt variant aris mtdna haplogroup ha background extrem rare combin analysi transmitochondri cybrid h mtdna reveal lower mitochondri respir increas reactiv oxygen speci product mros dysregul connect tissu gene express mitochondri dysfunct exacerb histamin explain eight surviv children inherit dysfunct histidin decarboxylas allel wx father thus certain combin common mtdna variant caus mitochondri dysfunct mitochondri dysfunct affect extracellular matrix gene express histamin activ mros product augment sever mitochondri dysfunct import identifi previous unreport genet caus mitochondri disord aris incompat common nonpathogen mtdna variant
|
D004272;D006632
|
T123;T121;T114;T109
|
36,322,730
|
unexpect role leucyl aminopeptidas uv toler reveal genom wide fit assess model cyanobacterium uv radiat uvr signific physiolog effect organ live near earth surfac yet full suit gene requir fit photosynthet organ uvr rich environ remain unknown studi report genom wide fit assess gene affect uvr toler environment relev uvr dosag model cyanobacterium synechococcus elongatus pcc result highlight import specif gene encod protein involv dna repair glutathion synthesi assembl mainten photosystem ii well gene encod hypothet protein other without obvious connect canon method uvr toler disrupt gene encod leucyl aminopeptidas lap confer greatest uvr specif decreas fit enzymat assay demonstr strong ph depend affin lap dipeptid cysteinyl glycin suggest involv glutathion catabol function night time cytosol ph level low differenti express lap gene acut uvr exposur suggest relat import would overlook transcript depend screen subsequ experi reveal similar uvr sensit phenotyp lap knockout organ indic conserv function role lap uvr toler
|
D007931;D014466
|
T070;T126;T116
|
36,322,729
|
gene deliveri avail molluscan cell strong promot discov bivalv infecti virus understand gene function marin invertebr limit larg due lack suitabl assay system system requir investig method reproduc quantit evalu cell line strong promot drive high express transgen studi establish primari cell cultur marin bivalv mollusc mizuhopecten yessoensi use scallop primari cell optim electropor condit transfect carri luciferas base promot activ assay identifi strong promot sequenc drive express gene interest evalu potenti promot sequenc gene endogen exogen origin discov strong viral promot deriv bivalv infecti virus ostreid herpesvirus oshv promot term oshv promot show fold fold higher activ cytomegalovirus immedi earli cmv ie promot endogen ef promot two common use promot bivalv far gfp assay show oshv promot activ scallop cell also hek cell zebrafish embryo oshv promot practic enabl function analysi marin molluscan gene contribut unveil gene regulatori network under astonish regener adapt reproduct age marin invertebr
|
D015027;D049872
|
T204;T013
|
36,322,728
|
develop mass allel exchang techniqu enabl sexual genet escherichia coli despit dramat advanc genom connect genotyp phenotyp still challeng sexual genet combin linkag analysi power solut problem general unavail bacteria build upon strong negat select system invent mass allel exchang mae enabl hybrid arbitrari includ pathogen strain escherichia coli mae reimplement natur phenomenon random cross over enabl classic linkag analysi demonstr util mae virul relat gain function screen discov transfer singl operon uropathogen strain suffici enabl commens e coli form larg intracellular bacteri collect within bladder epitheli cell mae thus enabl assay natur allel variat e coli potenti bacteria complement exist loss function genom techniqu
|
D056689;D014552;D004927;D029968
|
T047;T007;T116
|
36,322,726
|
spatial scale tuberculosi transmiss lima peru spatial target intervent may effect altern individu popul base prevent strategi tuberculosi tb howev efficaci may depend mechan lead geograph constrain hotspot local tb incid may reflect high level local transmiss convers may point frequent travel communiti member high risk area use whole genom sequenc explor pattern tb incid transmiss lima peru recruit incid pulmonari tb patient household contact follow occurr tb diseas use whole genom sequenc mycobacteri tuberculosi isol patient estim pariwis genom distanc compar spatial distanc patient resid genom distanc increas rapid spatial distanc increas remain high beyond km separ next divid studi catchment area km grid cell surfac unit use household spatial coordin locat tb patient specif cell estim cell specif transmiss calcul proport patient cell pairwis genom distanc fewer singl nucleotid polymorph found cell specif tb incid local transmiss vari wide cell specif tb incid correl close estim local transmiss cohen k find indic understand spatial heterogen relat proport tb due local transmiss may help guid implement spatial target intervent
|
D014376;D009169;D014397
|
T047;T007
|
36,322,725
|
rapid homeostat modul transsynapt nanocolumn ring robust neural inform transfer reli delic molecular nano architectur chemic synaps neurotransmitt releas control specif arrang protein within presynapt activ zone specif presynapt molecular architectur relat postsynapt organ synapt nano architectur transsynapt regul enabl stabl synapt transmiss remain enigmat use time gate stimul emiss deplet microscopi drosophila neuromuscular junction found presynapt nanor form activ zone scaffold bruchpilot brp align postsynapt glutam receptor glur ring individu ring harbor approxim four transsynapt align brp glur nanocolumn similar nanocolumn ring form presynapt protein unca glur intrigu acut glur impair trigger transsynapt nanocolumn format minut timescal homeostat plastic reveal distinct phase structur transsynapt homeostat plastic postsynapt glur reorgan preced presynapt brp modul final homeostat control transsynapt nano architectur neurotransmitt releas requir auxiliari glur subunit neto thus transsynapt nanocolumn ring provid substrat rapid homeostat stabil synapt efficaci
|
D009469;D029721
|
T026;T123;T023;T116
|
36,322,724
|
genet algorithm reveal profound individu differ emot recognit emot communic reli mutual understand express viewer facial configur broadcast specif emot howev know whether peopl share common understand emot state map onto facial express express exist high dimension space larg explor convent experiment paradigm address adapt genet algorithm combin photorealist three dimension avatar effici explor high dimension express space total peopl use tool generat facial express repres happi fear sad anger found substanti variabl express generat via procedur suggest differ peopl associ differ facial express emot state examin whether variabl facial express creat could account differ perform standard emot recognit task ask peopl categor differ test express found emot categor perform explain extent test express match express generat individu find reveal breadth variabl peopl represent facial emot even among typic adult popul profound implic interpret respons emot stimuli may reflect individu differ emot categori peopl attribut particular facial express rather differ brain mechan produc emot respons
|
D007206;D000066499
|
T041;T054
|
36,322,723
|
spatial turnov soil viral popul genotyp overlain cohes respons moistur grassland virus shape microbi communiti food web dynam carbon nutrient cycl divers ecosystem howev littl known pattern driver viral communiti composit particular soil preclud predict understand viral impact terrestri habitat investig soil viral communiti assembl process analyz soil virom rainfal manipul experi mediterranean grassland california identifi viral popul viral oper taxonom unit votus repres sequenc kbp found viral communiti composit exhibit high signific distanc decay relationship within field site pattern recapitul intrapopul microheterogen trend preval votus detect virom tend exhibit negat correl spatial distanc genom similar predomin allel variant although signific spatial structur also observ bacteri archaeal communiti signal dampen relat virom suggest differ local assembl driver virus prokaryot andor differ tempor scale captur virom total dna despit overwhelm spatial signal evid environment filter reveal protein share network analysi wherein group relat votus predict infect actinobacteria shown signific enrich low moistur sampl distribut throughout field overal result indic high divers dynam activ spatial structur soil virospher capabl rapid respons chang environment condit
|
D064307;D014780
|
T001;T005;T032;T028
|
36,322,721
|
cryo electron microscopi structur h h octasom nucleosom like particl without histon ha hb canon nucleosom repres major packag unit eukaryot chromatin octamer core compos two histon ha hb h h dimer base pair bp dna wrap around non nucleosom particl altern histon stoichiometri dna wrap configur found could profound influenc genom architectur function use cryo electron microscopi solv structur h h octasom nucleosom like particl di tetramer core consist exclus h h histon core wrap bp dna negat superhel turn form two stack disk connect h h four helix bundl three conform correspond altern interdisk angl observ indic flexibl h h octasom structur vivo crosslink experi detect histon histon interact consist h h octasom model suggest h h octasom relat structur featur exist cell
|
D009707;D006657
|
T123;T116
|
36,322,720
|
flexibl integr continu sensori evid perceptu estim task tempor accumul evid crucial make accur judgment base noisi ambigu sensori input integr process lead categor decis thought reli competit neural popul encod discret categor choic recurr neural circuit integr evid continu perceptu judgment unknown show continu bump attractor network integr circular featur stimulus direct near optim requir optim integr popul activ network unfold two dimension manifold posit network activ bump track stimulus averag simultan bump amplitud track stimulus uncertainti moreov tempor weight sensori evid network depend relat strength stimulus compar intern generat bump dynam yield either earli primaci uniform late recenc weight model flexibl switch regim chang singl control paramet global excitatori drive show mechan quantit explain individu tempor weight profil human observ valid model predict tempor weight impact reaction time find point continu attractor dynam plausibl neural mechan under stimulus integr perceptu estim task
|
D003657
|
T041
|
36,322,719
|
anti angiogen properti microrna preclin ocular model abnorm neovascular import caus blind mani ocular diseas etiolog pathogen mechan remain incomplet understood recent studi reveal divers role noncod rnas various biolog process facilit research develop clinic applic numer rna drug includ microrna report antiangiogen activ microrna mir three anim model ocular neovascular mir knockout ko mice display enhanc vessel prune result decreas vascular area retin develop contrast mir delet adult mice acceler angiogenesi preclin diseas model includ corneal neovascular oxygen induc retinopathi choroid neovascular administr agomir amelior patholog neovascular furthermor mir exert inhibitori effect endotheli cell prolifer migrat tube format capac rna sequenc analysi retina mir ko mice rna interfer experi identifi platelet deriv growth factor c sever extracellular matrix gene downstream target mir involv regul ocular angiogenesi data suggest mir may promis clinic candid treatment neovascular diseas
|
D035683;D020256
|
T123;T046;T114
|
36,322,718
|
special metabol pathway partit citrat hydroxyapatit impact miner bone teeth citrat critic metabol substrat key regul energi metabol mammalian cell known decad skeleton contain gt bodi citrat question metabolit partit bone receiv singular littl attent show osteoblast use special metabol pathway regul uptak endogen product deposit citrat bone osteoblast express high level membran na depend citrat transport solut carrier famili member slca gene inhibit genet disrupt slca reduc osteogen citrat uptak disrupt miner nodul format bone mice lack slca global select osteoblast show equival reduct cortic thick similar compromis mechan strength surpris citrat content miner slca osteoblast increas fourfold relat control suggest engag compensatori mechan augment endogen citrat product inde coordin function apic membran citrat transport slca mitochondri zinc transport protein zip encod slca mediat citrat efflux tricarboxyl acid cycl slca mediat citrat entri blood activ exert homeostat control cytoplasm citrat intrigu slca defici mice also exhibit defect tooth enamel dentin format clinic featur show recapitul primari teeth children slca mutat togeth result reveal compon osteoblast metabol pathway affect bone strength regul citrat deposit miner hydroxyapatit
|
D019343;D027981
|
T123;T121;T116;T109
|
36,322,717
|
tmemb essenti inflamm tissu injuri induc mechan pain hypersensit persist mechan pain hypersensit associ peripher inflamm surgeri trauma nerv injuri impair patient qualiti life daili activ howev molecular mechan treatment yet fulli understood herein show chemic ablat isolectin b bind ib affer ib saporin inject sciatic nerv complet select inhibit inflamm tissu injuri induc mechan pain hypersensit thermal mechan pain hypersensit normal follow nerv injuri determin molecular mechan involv specif type mechan pain hypersensit compar gene express profil ib neuron ablat control dorsal root ganglion drg neuron identifi tmemb one candid gene specif somatosensori ganglia regul ib neuron ablat inde tmemb express predomin ib drg neuron select local tran golgi apparatus drg neuron detect peripher central branch drg axon tmemb express bare detect spinal cord brain although tmemb knockout mice show normal respons noxious heat noxious mechan stimuli normal condit mechan pain hypersensit select impair inflamm tissu incis reproduc pain phenotyp ib sensori neuron ablat mice furthermor acut knockdown intrathec inject tmemb small interf rna either inflamm induct success reduc mechan pain hypersensit thus studi demonstr tmemb essenti inflamm tissu injuri induc mechan pain hypersensit highlight tmemb therapeut target futur treatment
|
D011788;D006967
|
T078;T046
|
36,322,672
|
rate futur lumbar fusion patient cauda equina syndrom treat decompress long term risk convers lumbar fusion ill defin patient cauda equina syndrom ces treat decompress studi aim identifi rate fusion patient ces compar rate match lumbar spinal stenosi lss group
|
D000077684;D013130
|
T047;T020
|
36,322,669
|
tissu wide genet cellular landscap shape execut sequenti prc function neural stem cell lineag progress generat correct size cerebr cortex embrac neuron glial cell type divers critic depend faith radial glial progenitor rgp cell proliferationdifferenti program tempor rgp lineag progress regul polycomb repress complex prc loss prc activ result sever neurogenesi defect microcephali prc depend gene express instruct rgp lineag progress unknown use mosaic analysi doubl marker madm base singl cell technolog demonstr prc cell autonom requir neurogen rgps rather act global tissu wide level convers cortic astrocyt product matur cell autonom control prc depend transcript regul thus reveal high distinct sequenti prc function rgp lineag progress depend complex interplay intrins tissu wide properti broader context result impli critic role genet cellular nich environ neural stem cell behavior
|
D063151;D058953
|
T126;T116;T025
|
36,322,666
|
multiplex high throughput immun cell imag reveal molecular health associ phenotyp phenotyp plastic essenti immun system yet factor shape fulli understood comprehens analyz immun cell phenotyp includ morpholog across human cohort singl round multiplex immunofluoresc autom microscopi deep learn use uncertainti convolut neural network cluster phenotyp eight distinct immun cell subset find result map influenc donor age gender blood pressur reveal distinct polar activ associ phenotyp across immun cell class associ cell morpholog transcript state base joint donor variabl valid inflamm associ polar cell morpholog age associ loss mitochondria cd cell togeth show immun cell phenotyp reflect molecular person health inform open new perspect deep immun phenotyp individu peopl health diseas
|
D016571;D007249
|
T170;T046
|
36,322,662
|
untangl role topa topb transcript cancer type ii topoisomeras top conserv regul chromatin topolog catalyz revers dna doubl strand break dsbs essenti maintain genom integr divers dynam process transcript replic cell divis control top mediat dsbs eleg solut topolog constraint dna dsbs also contribut emerg chromosom transloc mutat drive cancer central import top enzym frontlin chemotherapeut target well known howev precis biolog function impact cancer develop still poor understood review provid updat overview topa topb regul chromatin topolog transcript discuss recent discoveri link top activ cancer pathogenesi
|
D004268;D009369
|
T123;T191;T116
|
36,322,658
|
singl cell multiom identifi clinic relev mesenchym stem like cell key regul mpnst malign malign peripher nerv sheath tumor mpnst high aggress schwann cell sc deriv soft tissu sarcoma aris benign neurofibroma nf howev ident heterogen origin tumor popul remain elus nestin cell implic tumor stem cell mpnst unexpect singl cell profil human nf mpnst anim model reveal broad rang nestin express sc lineag cell dynam acquisit discret cancer state malign transform uncov nestin negat mesenchym neural crest like subpopul previous unknown malign stem like state common murin human mpnsts correl clinic sever integr multiom profil identifi uniqu regulatori network druggabl target malign subpopul mpnst target key epitheli mesenchym transit stem regul includ zeb aldha imped mpnst growth togeth studi reveal under principl tumor cell state evolut regulatori circuitri nf mpnst transform highlight hitherto unrecogn mesenchym stem like subpopul mpnst diseas progress
|
D018319;D018317;D009455
|
T191
|
36,322,653
|
lipid mediat supramolecular outer membran protein assembl bacteria barrel outer membran protein omp cluster supramolecular assembl give function outer membran om gram negat bacteria assembl form unknown photoactivat cross link escherichia coli om coupl simul biochem biophys analysi uncov basi omp cluster vivo omp typic surround annular shell asymmetr lipid mediat higher order complex neighbor omp omp assembl center abund porin ompf ompc low abund monomer barrel tonb depend transport pack studi reveal omp lipid omp complex basic unit supramolecular omp assembl extend across entir cell surfac coupl requisit multifunct om stabil imperm
|
D029968
|
T116
|
36,322,637
|
outcom stem stemless total shoulder arthroplasti systemat review meta analysi random control trial stem stemless design total shoulder arthroplasti tsa demonstr efficaci outcom surgic treatment primari glenohumer joint osteoarthr purpos systemat review meta analysi compar clinic outcom stem versus stemless tsa random control trial hypothes would differ constant score cs rang motion advers event periprosthet fractur andor revis surgeri
|
D000072228;D057068;D010003
|
T061;T047;T037
|
36,322,636
|
use general anesthesia pediatr dentistri saskatchewan retrospect studi rate general anesthesia ga use pediatr dental treatment saskatchewan among highest canada although preval risk factor earli childhood cari ecc review nation studi focus saskatchewan object studi determin preval predict factor dental treatment ga saskatchewan
|
D003731;D000766
|
T033;T047;T061
|
36,322,635
|
bell palsi etiolog manag dental implic bell palsi common mononeuropathi caus acut unilater facial paralysi paresi condit peak within h may associ numer sign symptom includ post auricular pain droop eyelid loss tast sensat decreas lacrim although etiolog condit unknown inflamm viral infect ischemia anatomi facial nerv implic pathophysiolog diseas diagnosi determin etiolog signific earli manag condit incid resolv spontan howev treatment reduc case incomplet recoveri entail use corticosteroid possibl role antivir viral etiolog suspect patient incomplet recoveri long term complic esthet physiolog psycholog implic great affect qualiti life purpos articl summar current literatur etiolog diagnosi manag bell palsi
|
D020330;D005158
|
T184;T047
|
36,322,634
|
use unsaf teeth remedi survey various teeth remedi wide market caregiv unsaf remedi includ teeth necklac topic anesthet implic advers event suffoc injuri death howev littl known extent use primari object assess preval teeth remedi use among caregiv secondari object determin whether use unsaf teeth remedi relat socioeconom status ses matern educ
|
D014078;D000779
|
T033;T121;T109;T042
|
36,322,633
|
patient characterist associ develop oral lichen planus two provinc canada understand risk factor may associ develop oral lichen planus olp progress
|
D017676;D009062;D002294
|
T047;T191
|
36,322,632
|
target cancer glycosyl repolar tumor associ macrophag allow effect immun checkpoint blockad immun checkpoint blockad icb substanti improv prognosi patient cancer major experi limit benefit support need new therapeut approach regul sialic acid contain glycan term hypersialyl common featur cancer associ glycosyl drive diseas progress immun escap engag siglec receptor tumor infiltr immun cell show tumor sialyl correl distinct immun state reduc surviv human cancer target remov siglec ligand tumor microenviron use antibodi sialidas conjug enhanc antitumor immun halt tumor progress sever murin model use singl cell rna sequenc reveal desialyl repolar tumor associ macrophag tam also identifi siglec e main receptor hypersialyl tam last found genet therapeut desialyl well loss siglec e enhanc efficaci icb thus therapeut desialyl repres immunotherapeut approach reshap macrophag phenotyp augment adapt antitumor immun respons
|
D000082082;D009369
|
T129;T121;T191;T043
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.