Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,320,187	factor affect need postop blood transfus elder patient intertrochanter hip fractur investig risk factor increas frequenc blood transfus elder patient intertrochanter hip fractur determin blood transfus risk surgeri take select precautionari measur group high risk transfus ensur safe surgeri	D006620	T037
36,320,153	earli onset senesc imbalanc epiderm homeostasi across decad photoexpos human skin fingerprint inflammag inflammag theori age purport low level chronic inflamm lead cellular dysfunct prematur age surround tissu skin suscept inflammag first line defenc environ particular solar radiat better understand impact age photoexposur epiderm biolog perform system biolog base analysi photoexpos face arm photoprotect buttock site women age biopsi analys histolog transcriptom proteom skin surfac biomark collect tape strip identifi morpholog chang age epiderm thin rete ridg pathlength loss stratum corneum thicken sasp biomark il il rail consist elev face across age cistran urocan acid elev arm face age older arm dna damag respons biomark bp show higher puncti number basal layer epigenet age acceler gene associ differenti senesc show increas express wherea gene associ hypoxia glycolysi increas proteom compar vs confirm elev level differenti glycolyt relat protein repres immunostain protein differenti senesc oxygen sensinghypoxia show similar relationship system biolog base analysi provid bodi evid young photoexpos skin undergo inflammag propos presenc chronic inflamm young skin contribut imbal epiderm homeostasi lead prematur age appear later life	D004817;D012867	T022;T024
36,320,146	system sclerosi cerebr infarct sever stenosi intern carotid arteri coronari arteri case report system sclerosi ssc chronic autoimmun diseas character microangiopathi extens fibrosi autoantibodi product general believ microvascular diseas hallmark ssc macrovascular involv initi consid featur ssc mortal high ignor present ssc patient cerebr involv multipl macrovascular stenosi rare describ herein report case cerebr infarct sever stenosi intern carotid arteri coronari arteri associ ssc	D002343;D012595	T023;T047
36,320,141	unexplain abdomin pain caus fractur thorac vertebra background import identifi caus chronic abdomin pain especi older adult thoracolumbar vertebr compress fractur one potenti caus difficult identifi report case older man sever unexplain abdomin pain nausea due inadequ treat thoracolumbar vertebr compress fractur case report year old man fell day prior visit hospit diagnos compress fractur th vertebra start wear corset day injuri two day later develop abdomin pain mild nausea decreas appetit attribut symptom wear corset therefor stop wear caus abdomin symptom could determin blood test comput tomographi abdomen upper bodi elev induc mark right lower abdomin pain consist domin region th l decreas temperatur sensat observ region conclud abdomin pain caus neuropathi owe ruptur th vertebr fractur patient treat conserv abdomin pain nausea resolv week admiss patient discharg conclus assess patient unexplain abdomin pain vertebr compress fractur includ differenti diagnosi necessari diagnost assess made earli possibl earli diagnosi provid wider rang treatment option contribut minim function declin	D050815;D016103	T046;T037
36,320,129	influenc surfac type coffe immers surfac topographi optic mechan properti select ceram materi background aim studi assess compar effect surfac type glaze polish coffe immers age surfac topographi ra optic properti tp op mechan properti fractur forc mode zirconia reinforc lithium silic vita suprin hybrid polym infiltr feldspath ceram network materi vita enam leucit contain feldspath glass vitabloc mark ii made comput aid design comput aid manufactur cadcam ceram materi materi method fifti four specimen assembl cadcam ceram materi group divid glaze polish surfac specimen everi type stain coffe day ra color specimen form tp op record immers stain materi fractur forc mode analyz day age data analyz use anova post hoc analysi bonferroni test result studi found signific differ ra tp op coffe immers glaze polish specimen higher valu polish surfac among ceram materi highest valu fractur resist note vita suprin vita enam lowest valu without signific differ among group conclus tp op valu accept clinic rang vita suprin superior tp group repar fractur type observ vita suprin wherea semi repar non repar predomin group	D003069;D007101	T060;T168;T037
36,320,118	circul cell free messeng rna enabl non invas pan tumour monitor melanoma therapi independ mutat genotyp plasma deriv tumour specif cell free nucleic acid increas util minim invas real time biomark approach mani solid tumour circul tumour dna melanoma specif mutat current best studi liquid biopsi biomark melanoma howev combin hotspot genet alter cover around melanoma patient therefor altern approach need enabl follow genotyp includ wild type	D008545;D000073888;D009506	T123;T191;T114
36,320,115	phylogenet characterist fasciola hepatica isol korean patient fascioliasi parasit infect caus liver fluke although sever case report korea phylogenet analysi isol lack studi year old woman right upper quadrant ruq abdomin pain diagnos fascioliasi involv abdomin muscl imag studi receiv praziquantel treatment symptom improv later movement abscess lesion follow trematod parasit surgic remov patient rectus abdomini muscl fluke identifi fasciola hepatica base sequenc analysi rdna determin phylogenet posit fasciola strain name korean fasciola kf cox gene bp analyz compar gene f hepatica strain isol cow sheep goat human various countri phylogenet analysi show kf close relat isol china goat	D005210;D005211;D005209;D012757	T047;T204
36,320,114	alaria alata digenea diplostomida korean raccoon dog nyctereut procyonoid koreensi korea report speci diplostomid fluke recov carcass wild korean raccoon dog nyctereut procyonoid koreensi korea total diplostomid fluke recov small intestin korean raccoon dog obtain gangwon wildlif medic rescu center worm fix neutral formalin subject microscop observ fix ethanol use molecular genom analysi worm divid separ part forebodi hindbodi total length width boat shape forebodi pair characterist tentacular appendag sucker holdfast organ vitellin follicl oval cylindr hindbodi reproduct organ ovari round ellipt locat anterior test two larg test slight segment tandem arrang occupi almost half hindbodi short uterus contain relat small number unembryon egg size partial sequenc rrna fluke consist alaria alata base morpholog molecular characterist diplostomid fluke recov small intestin korean raccoon dog identifi alata digenea diplostomida	D046031;D014200	T015;T204
36,320,113	excretori secretori product trichomona vaginali caus apoptosi mous sperm vitro excretori secretori product esp vaginali shown inhibit sperm motil viabil function integr lead decreas fertil rate vitro studi investig whether vaginali induc apoptosi ultrastructur chang sperm use flow cytometri electron microscopi incub sperm vaginali esp increas phosphatidylserin extern dna fragment decreas mitochondri membran potenti transmiss electron microscopi sperm incub esp reveal abnorm featur distort head broken neck acrosom exocytosi first report demonstr direct impact vaginali esp sperm apoptosi architectur vitro	D014246	T204
36,320,112	cerebr paragonimiasi present dementia report case year old korean man chronic cerebr paragonimiasi present progress memori impair suffer pulmonari paragonimiasi year ago experienc epilepsi sinc age began experienc memori cognit deterior year ago visit neuropsychiatr depart hospit check symptom health year ago contrast enhanc brain magnet reson imag studi reveal calcif cystic lesion encompass right temporo occipit region encephalomalat chang also observ right occipit tempor area anti paragonimus specif igg antibodi serum show strong posit respons neuropsycholog test result show global deterior scale clinic dementia rate scale chronic cerebr paragonimiasi lesion patient right temporo occipit region might induc dement chang	D010237;D010238;D003704	T047;T204;T048
36,320,111	biolog characterist recombin arthrobotri oligospora chitinas ao chitinas ao hydrolas secret arthrobotri oligospora nematod feed role remain elus studi analyz molecular characterist recombin chitinas arthrobotri oligospora reao ao belong typic glycosid hydrolas famili conserv chitinas sequenc tertiari structur trios phosphat isomeras tim barrel molecular weight reao kda reao effect degrad colloid powder chitin egg lysat stage larval lysat caenorhabd elegan activ reao reach peak c ph valu enzym activ inhibit zn ca fe wherea mg k potenti activ addit urea sodium dodecyl sulfat mercaptoethanol signific inhibit enzym activ reao show complet nematicid activ c elegan stage larva reao broke c elegan egg shell caus die die prematur hatch egg also invok degrad haemonchus contortus egg result appar chang morpholog structur studi demonstr cytotox effect reao laid foundat dissect mechan nematod infest oligospora	D002688;D001203;D009348	T004;T126;T116;T204
36,320,110	antimalari efficaci aqueous extract strychno ligustrina combin dihydroartemisinin piperaquin phosphat dhp plasmodium berghei infect develop drug resist one sever concern malaria control increas risk malaria morbid death new candid drug antiplasmodi activ urgent need studi evalu efficaci differ dosag aqueous extract strychno ligustrina combin dihydroartemisinin piperaquin phosphat dhp murin plasmodium berghei infect balbc mice age week divid group consist mice growth inhibit compound p berghei monitor calcul percentag parasitemia result show mice receiv aqueous extract combin treatment show growth inhibit p berghei respect ligustrina extract consist brucin strychnin effect inhibit multipl p berghei treat mice show improv hematolog profil bodi weight temperatur compar control mice co treatment ligustrina extract dhp reveal signific antimalari antipyret effect result provid prospect discoveri antimalari drug may show success chemotherapeut treatment	D000962;D031451;D008288;D037621	T121;T047;T002;T109
36,320,109	spatiotempor cluster trend pneumocysti pneumonia korea studi determin recent status trend pneumocysti jirovecii pneumonia pcp non human immunodefici virus hiv non hiv pcp hiv hiv pcp infect popul use data health insur review assess servic hira korea diseas control prevent agenc kdca satscan joinpoint use statist analys non hiv pcp case show upward trend studi period largest number case upward trend similar adjust popul seoul highest number case non hiv pcp group adjust popul case follow jeju case like cluster mlc non hiv pcp group seoul relat risk rr log likelihood ratio llr follow jeju rr llr upward trend observ among non hiv pcp group jeju dojeollanam dojeollabuk dogyeongsangnam dobusandaejeondaeguulsan joint cluster llr p locat southern part korea women men non hiv group show overal upward trend pcp studi period men age group highest annual percentag chang apc contrast hiv group show fall trend pcp recent men age group decreas apc studi provid analyt basi health measur nationwid epidemiolog surveil system manag pcp	D045363;D011020;D015658	T047;T004
36,320,108	hypoxia induc factor alpha stabil human macrophag leishmania major infect impair parasit virul hypoxia induc factor alpha hif one master regul immun metabol cellular function hif transcript factor whose activ close relat oxygen level target understand infecti diseas control sever studi demonstr hif play import role infecti process role relat parasit virul address work studi express level hif relat angiogen vascular endotheli growth factor vegf human macrophag infect promastigot hypo hyper virul leishmania major human isol l major parasit readili subvert host macrophag function surviv induc local oxygen consumpt site infect contrast hypo virul parasit induc high hif express level hyper virul l major reduc hif express macrophag normox hypox condit consequ imped express vegf mrna hif may play key role control diseas chronic sever outcom	D018320;D010271;D007896	T047;T204
36,320,107	treatment extracellular vesicl giardia lamblia allevi dextran sulfat sodium induc coliti cbl mice inflammatori bowel diseas ibd chronic recurr ill gastrointestin tract treatment ibd tradit involv use aminosalicyl acid steroid drug associ untoward effect refractori absenc effect treatment regimen ibd led explor new target parasit promis altern therapi ibd recent studi highlight use parasit deriv substanc excretori secretori product extracellular vesicl ev exosom treatment ibd report examin whether ev secret giardia lamblia could prevent coliti mous model g lamblia ev glev prepar vitro cultur giardia trophozoit clinic sign microscop colon tissu inflamm cytokin express level detect assess effect glev treatment dextran sulfat sodium dss induc experiment murin coliti administr glev prior dss challeng reduc express level pro inflammatori cytokin includ tumor necrosi factor alpha interleukin beta interferon gamma result indic glev exert prevent effect possess therapeut properti dss induc coliti	D016829;D003092;D015212;D000067128	T026;T047;T204
36,320,090	oxid stress respons small extracellular vesicl microrna age relat macular degener biomark therapeut tool age relat macular degener amd main caus blur vision oxid stress lead risk factor amd patholog small extracellular vesicl ev nm membran microvesicl mvs releas sever cell type control fashion transfer cell cell mediat diseas progress ev encapsul transfer microrna mirna recipi cell mirna small non code rna molecul inhibit express function target mrnas mirnamrna interact conserv utr region way modul varieti physiolog patholog process dysregul ev mirna cargo retin cell believ correl loss cellular homeostasi amd patholog review investig associ oxid stress sev mirna amd pathogenesi potenti discov novel treatment target amd	D035683;D008268;D000067128	T026;T123;T047;T114
36,320,089	connect earli life advers post traumat stress disord updat review human be develop high coordin flexibl system social behavior threat evalu review focus uniqu role earli life advers ela program deficit social behavior threat process provid guidanc futur investig area stress reactiv mental health propos neuroendocrin perturb hypothalamus pituitari adren hpa axi gene activ epigenet mechan may explain earli advers circumst may lead post traumat stress disord ptsd detail explor interact stress environment factor epigenet genet regul hpa axi may improv target intervent among vulner individu convinc studi follow direct contribut effect prevent treatment ptsd earli traumat patient	D013313;D000076783	T033;T048
36,320,087	flecainid induc pneumon case report report case acut respiratori distress associ histolog pattern acut fibrin organ pneumonia discuss possibl respons flecainid therapi	D011014;D018549	T047;T050
36,320,086	presum bietti crystallin dystrophi optic nerv head drusen case report bietti crystallin dystrophi primarili retin dystrophi caus cypv mutat typic present crystallin retin deposit posterior fundus	D009898;D015594;D012162	T033;T023;T046;T047
36,320,085	differenti hypomethyl cell free dna coronari collater circul factor affect cardioprotect collater circul still incomplet understood recent characterist cpg methyl cell free dna cfdna report marker clinic util aim studi evalu whether cfdna methyl pattern associ grade coronari collater circul ccc	D000073888;D003324	T123;T047;T114
36,320,082	diagnost util csf immunohistochemistri tenosynovi giant cell tumor differenti giant cell rich tumor tumor like lesion bone soft tissu tenosynovi giant cell tumor tsgct benign fibrohistiocyt tumor affect synovium joint bursa tendon sheath categor local tsgct ltsgct diffus tsgct dtsgct ltsgct dtsgct character recurr fusion involv coloni stimul factor csf gene transloc partner collagen type vi alpha chain fusion gene induc intratumor overexpress csf mrna csf protein csf express characterist find tsgct detect csf mrna csf protein may use patholog diagnosi although effect anti csf antibodi date situ hybrid ish csf mrna perform detect csf express tsgct perform csf immunohistochemistri ihc use anti csf antibodi clone case tsgct giant cell rich tumor gcrt gcrt like lesion verifi util patholog diagnosi tsgct	D000070779;D005870	T191
36,320,080	continu field flood versus final one shot co insuffl minim invas mitral valv repair insuffl carbon dioxid co oper field prevent cerebr myocardi damag air embol well known strategi open heart surgeri howev general consensus best deliveri approach	D007327;D006348	T061;T058
36,320,078	person characterist associ satisfact healthcar wish complain increas evid satisfact healthcar complaint rate vari patient socio demograph characterist likewis patient person might influenc percept health care howev empir research scarc aim studi investig associ health care user person satisfact care urg complain	D010549;D010551	T033;T041
36,320,077	prophylact antibiot use labor deliveri china nationwid multicent hospit base cross section studi prophylact antibiot use deliveri common routin obstetr practic prevent infect global especi low middl incom countri china howev littl current known nation estim prophylact antibiot use deliveri therefor aim describ preval prophylact antibiot use guidelin adher use nation data china	D007743;D011248	T040;T046
36,320,076	combin impact persist infect human genet variat c reactiv protein level multipl human pathogen establish chronic sometim life long infect even often latent infect trigger degre local system immun respons result chronic low grade inflamm remain incomplet understand potenti contribut persist infect human genet variat chronic low grade inflamm search potenti associ seroposit persist pathogen plasma level inflammatori biomark c reactiv protein crp use data collect context uk biobank colauspsycolaus studi two larg popul base cohort perform backward stepwis regress start follow potenti predictor serostatus pathogen polygen risk score crp demograph clinic factor known associ crp found evid associ chlamydia trachomati p valu e helicobact pylori p valu e seroposit higher plasma level crp also found associ pathogen burden crp level p valu e result improv understand relationship persist infect chronic inflamm import determin long term morbid human	D016481	T047
36,320,074	role biomark diagnosi invas aspergillosi immunocompromis patient invas aspergillosi one import caus infect immunocompromis patient studi aim evalu role biomark diagnosi invas aspergillosi relationship antifung stewardship program	D001228;D000072742	T047
36,320,073	impair traffick instabl mutant kidney anion exchang protein associ autosom recess distal renal tubular acidosi mutat solut carrier famili member slca encod anion exchang ae common caus autosom recess distal renal tubular acidosi ar drta southeast asian explain molecular mechan diseas hematolog abnorm affect famili conduct genet analysi slca studi wild type mutant ae protein express human embryon kidney hekt cell	D001457;D007668	T123;T023;T116
36,320,072	b h target car cell show high effici anti tumor function osteosarcoma vitro vivo osteosarcoma os main happen children youth surgeri radiotherapi chemotherapi common therapi osteosarcoma treatment anti tumor effect limit recent year new cellular therapi car cellular immunotherapi genet engin cell bear chimer antigen receptor target specif tumor associ antigen prove effect therapi acut lymphoblast leukemia thus car potenti effect therapi osteosarcoma treatment	D000076962;D012516;D001859	T129;T191;T116;T192
36,320,071	summaris data factor associ covid relat conspiraci theori first year pandem systemat review narrat synthesi conspiraci theori particular harm effect negat shape health relat behaviour signific number covid specif conspiraci theori emerg immedi aftermath pandem outbreak aim studi systemat review literatur conspiraci theori relat covid first year pandem identifi preval determin public health consequ comprehens literatur search carri pubm psycinfo detect studi examin conspiraci theori relat covid januari st januari th forti three studi includ total particip particip agre least one conspiraci belief certain sociodemograph factor young age femal gender non white lower socioeconom status psycholog aspect pessim blame other anger qualiti polit conservat religios mistrust scienc use social media sourc inform associ increas accept conspiraci theori conspiraci belief led harm health relat behaviour pose serious public health threat larg scale collabor govern healthcar organ need curb spread conspiraci theori advers consequ	D000086382;D061108	T047;T170;T067
36,320,068	transgen anim model explor modul blood brain blood retin barrier cns uniqu environ brain retina tight regul blood brain barrier blood retin barrier respect ensur proper neuron function endotheli cell within tissu possess distinct properti allow control passag solut fluid pericyt glia cell neuron signal endotheli cell ec form maintain barrier control blood flow help creat neurovascular unit barrier lost wide rang diseas affect central nervous system cns retina brain tumor stroke dementia eye diabet retinopathi retin vein occlus age relat macular degener name promin exampl recent studi direct link barrier chang promot diseas patholog degrad neuron function understand barrier form restor barrier diseas provid import point therapeut intervent review aim describ fundament blood tissu barrier cns use transgen anim model led current understand molecular framework barrier review also highlight exampl target barrier properti protect neuron function diseas state	D001813;D001812	T023;T042
36,320,066	popul base estim correl oncotyp dx breast recurr score result ki ihc mib pharmdx hr node posit earli breast cancer unit state food drug administr recent approv ki immunohistochemistri ihc assay identifi patient earli breast cancer high diseas recurr risk oncotyp dx breast recurr score assay valid hormon receptor posit hr human epiderm growth factor receptor negat invas breast cancer ibc predict chemotherapi benefit distant recurr risk regardless nodal status studi assess correl recurr score rs result ki ihc mib pharmdx assay	D001943	T191
36,320,063	alter dna methyl express gene relat thyroid hormon metabol colon epithelium obes patient colorect cancer common among obes individu purpos current studi determin chang dna methyl status mrna express thyroid hormon receptor beta thrb tumor suppressor thyroid hormon inactiv enzym type deiodinas dio gene human epitheli colon tissu healthi obes individu	D019175;D037042	T116;T044;T192
36,320,062	turkish spanish pakistani medic student valu specialti train posit discret choic experi aim studi find specialti train prefer senior medic student three medic school turkey spain pakistan	D013337	T097
36,320,061	bayesian spatio tempor model map malaria anaemia among children month nigeria vital aspect diseas manag polici make lie understand univers distribut diseas nevertheless due differ host group space time outbreak activ data subject intricaci herein bayesian spatio tempor model propos model map malaria anaemia risk ratio space time well ascertain risk factor relat diseas endem state nigeria paramet estim perform employ r integr nest laplac approxim inla packag devianc inform criteria appli select best model	D008288;D000740	T047
36,320,060	associ abdomin obes indic risk cardiovascular event chines popul type diabet prospect cohort studi waist circumfer wc viscer adipos index vai lipid accumul product lap chines viscer adipos index cvai consid surrog indic abdomin fat deposit longitudin associ indic cardiovascular cv event adult type diabet td remain unclear studi aim examin associ abdomin obes indic incid cv event among peopl td compar predict perform risk assess	D003924;D002318	T047
36,320,059	presenc impact multimorbid cluster advers outcom across spectrum kidney function multimorbid presenc two chronic condit common amongst peopl chronic kidney diseas unclear condit cluster togeth chang kidney function declin explor cluster condit associ differ estim glomerular filtrat rate egfr studi associ cluster advers outcom	D059350;D051436;D001281;D006333	T184;T047;T046
36,320,058	non adjust surgeri acut acquir comit esotropia general anesthesia investig surgic result non adjust sutur techniqu general anesthesia correct acut acquir comit esotropia	D004948	T047
36,320,057	qualit studi gender inequ gender base violenc nepal gender inequ violenc mutual exclus phenomena complex loop affect women nepal face sever inequ violenc caus divers result due social assign lower posit women hierarchi base power make women face subordin violenc nepal studi aim explor particip understand experi identifi status inequ women violenc emerg one consequ furthermor explor caus sex traffick exampl outcom inequ violenc	D000074386	T033;T048
36,320,056	exosom biogenesi machineri regul therapeut implic cancer exosom well known key mediat intercellular communic contribut various physiolog patholog process biogenesi involv four key step includ cargo sort mvb format matur transport mvbs mvb fusion plasma membran process modul competit coordin multipl mechan wherebi divers repertoir molecular cargo sort distinct subpopul exosom result high heterogen exosom intrigu cancer cell exploit various strategi aberr gene express posttransl modif alter signal pathway regul biogenesi composit eventu function exosom promot cancer progress therefor exosom biogenesi target therapi activ explor review systemat summar recent progress understand machineri exosom biogenesi regul context cancer particular highlight pharmacolog target exosom biogenesi promis cancer therapeut strategi	D055354;D009369	T026;T191
36,320,055	forthcom complic recov covid patient copd asthma possibl therapeut opportun infect sever acut respiratori syndrom coronavirus sar cov grow swift worldwid patient background chronic pulmonari inflamm asthma chronic obstruct pulmonari diseas copd like infect virus note argument covid remain serious complic like fibrosi patholog chang pulmonari tissu patient chronic diseas along convent medic regen medicin cell base therapi could altern approach compens organ loss restor injur site use differ stem cell type owe uniqu differenti capac paracrin activ cell acceler heal procedur review articl tri scrutin differ report relat harm effect sar cov patient asthma copd well possibl therapeut effect stem cell allevi post covid complic video abstract	D000086382;D029424;D001249	T047;T067
36,320,054	de novo mutat within metabol network amino acidproteinenergi chines autist children intellectu disabl autism spectrum disord asd often accompani intellectu disabl id despit extens studi howev genet basi comorbid still clear studi tri develop analyz pipelin de novo mutat possibl pathway relat id phenotyp asd whole exom sequenc wes perform screen de novo mutat candid gene asd children togeth parent trio de novo alter gene relat pathway associ id phenotyp analyz connect node gene pathway select diagnost valu select gene id phenotyp studi popul also evalu	D000067877;D001321;D008607	T048
36,320,053	correl map genom wide dna methyl pattern pair human brain buccal sampl epigenom wide associ studi ewa assess link dna methyl dnam phenotyp relat structur brain measur cognit function neurodegen diseas becom increas popular due inaccess brain tissu human sever studi use peripher tissu blood buccal swab saliva surrog aid function interpret ewa find set need assess correl dnam variabl across tissu individu studi perform correl analysi dnam data total n match post mortem buccal prefront cortex sampl identifi near approxim cytosin phosphat guanin cpg site show signific fals discoveri rate q correl buccal pfc sampl correl cpg site show preponder locat promot region show signific enrich determin genet factor ie methyl quantit trait loci mqtl base buccal dorsolater prefront cortex mqtl databas novel buccal brain dnam correl map provid valuabl resourc futur ewa use buccal sampl studi dnam effect phenotyp relat brain correl result made freeli avail public onlin	D019175;D040641	T028;T044
36,320,048	relaps problem drink trade spirit use us nation cross section survey data highlight possibl negat impact potenti tobacco retail chang accord nation alcohol beverag control associ twelv state unit state us govern retail monopoli spiritsliquor sale new feder minimum legal sale age tobacco rais minimum legal sale age alcohol examin possibl unintend consequ hypothet polici chang restrict retail tobacco sale state run spiritsliquor store alcohol control state propos tobacco endgam strategi	D000437	T048
36,320,045	outcom right side left side colon diverticul follow non oper manag systemat review meta analysi suffici overview outcom right side left side colon diverticul cd follow non oper manag systemat review conduct evalu recurrencetreat failur right side left side cd	D004239	T047
36,320,044	work memori account emdr efficaci ptsd although eye movement desensit reprocess emdr shown effect treatment ptsd year remain controversi due lack understand mechan action examin whether work memori wm hypothesi competit limit wm resourc induc dual task attenu vivid emot traumat memori would provid explan benefici effect induc bilater stimul	D057169;D013313	T061;T048
36,320,043	pd fusion express dna vaccin elicit enhanc adapt immun respons hiv key role tlr sinc discoveri dna vaccin great interest abil elicit humor cellular immun respons show relat advantag regard produc stabil storag howev appli human subject inadequ immunogen remain greatest challeng practic use dna vaccin studi generat dna vaccin pd p encod fusion protein compris hiv gag p antigen extracellular domain murin pd novel endogen toll like receptor tlr agonist use mous model found pd p dna vaccin elicit higher antibodi respons increas number ifn produc cd cd cell moreov mice pd p dna vaccin protect subcutan challeng murin mesothelioma cell express hiv p antigen import pd mediat enhanc immun respons observ tlr knockout mice collect data demonstr immunogen efficaci dna vaccin could improv fusion extracellular domain pd target immunogen dendrit cell	D015497;D019444;D016915;D015658	T129;T121;T005;T114;T047
36,320,041	target hypoxia solid haematolog malign tumour hypoxia known extens research phenomenon occur solid haematolog malign cancer cell prolifer demand oxygen outstrip suppli reduc tumour oxygen solid tumour contribut disorgan blood vessel develop tumour hypoxia associ resist treatment aggress diseas behaviour increas likelihood metastat progress measur use invas non invas method vari degre accuraci presenc hypoxia stimul complex cellular network downstream factor includ hypoxia induc factor hif c x c motif chemokin cxcr hypoxia induc glycolyt enzym hexokinas hk amongst mani other work affect differ mechan includ influenc angiogenesi treatment resist immun surveil abil metastas contribut aggress diseas pattern tumour hypoxia correl poorer outcom wors prognosi patient correl hypox microenviron poor prognosi led interest tri therapeut target phenomenon various method use target hypox microenviron hypoxia activ prodrug hap drug activ within hypox environ agent subject investig sever clinic trial drug target downstream factor hypox environ includ hif inhibitor mammalian target rapamycin mtor inhibitor vascular endotheli growth factor anti vegf therapi also develop use combin clinic trial despit promis pre clinic data clinic trial hypoxia target strategi proven challeng understand effect hypoxia relat molecular mechan human rather anim model requir guid novel therapeut strategi futur trial design review discuss current avail method hypoxia target assess may consid plan futur clinic trial also outlin key trial date solid haemato oncolog treatment sphere discuss limit may impact clinic success date	D009369;D019337	T191
36,320,040	gata express clear cell adenocarcinoma lower urinari tract potenti diagnost pitfal clear cell adenocarcinoma lower urinari tract ccaclut rare primari malign neoplasm heterogen morpholog pauciti data literatur regard immunohistochem profil	D002295;D018262;D001749	T191
36,320,039	mendelian random analysi factor relat ovul reproduct function endometri cancer risk observ epidemiolog studi suggest link sever factor relat ovul reproduct function endometri cancer ec risk howev clear whether relationship causal whether risk factor act independ aim studi investig putat causal relationship number live birth age last live birth year ovul ec risk method conduct seri observ analys investig various risk factor ec risk uk biobank ukbb addit multivari analysi perform elucid relationship number live birth age last live birth year ovul relat factor age natur menopaus age menarch bodi mass index bmi second use mendelian random mr assess observ relationship causal genom wide signific singl nucleotid polymorph snps extract previous studi woman number live birth age menopaus menarch bmi conduct genom wide associ analysi use ukbb identifi snps associ year ovul year use contracept pill age last live birth	D057182;D016889	T062;T191
36,320,038	human intracrani pulsatil cardiac cycl comput model framework today avail medic imag comput resourc set scene high fidel comput model brain biomechan brain environ featur dynam complex interplay tissu blood cerebrospin fluid csf interstiti fluid isf design comput platform model simul intracrani dynam assess model valid term clinic relev indic brain pulsatil focus dynam interact tissu motion isfcsf flow treat pulsatil cerebr blood flow prescrib input model	D002552;D013346	T030
36,320,037	symptom prolong grief disord posttraumat stress disord depress relat griev icu famili first two year bereav bereav icu famili surrog risk comorbid prolong grief disord pgd posttraumat stress disord ptsd depress knowledg tempor relationship pgd ptsd depress limit lack relev studi divers inappropri assess time frame given durat criterion pgd aim determin tempor reciproc relationship pgd ptsd depress symptom among icu deced famili surrog first bereav year assess time frame reflect pgd durat criterion	D013313;D001601	T041;T048
36,320,036	steril insect techniqu pilot trial captiva island defin mosquito popul paramet steril male releas use mark releas recaptur steril insect techniqu sit involv area wide inund releas steril insect suppress reproduct target speci proven effect pest control method techniqu demand continu releas steril insect quantiti ensur high steril male wild male ratio suppress wild popul succeed generat	D000330;D007248	T033;T184;T047;T204
36,320,035	develop accredit standard midwiferi clinic educ iran accredit one import method qualiti assur improv medic educ iran specif midwiferi educ accredit standard studi design develop accredit standard midwiferi clinic educ iran	D008880;D004508	T065;T091;T097
36,320,034	late relaps ulcer coliti present tracheobronch case report lung involv inflammatori bowel diseas usual follow coliti howev time lung involv onset vari depend case pulmonari lesion usual parallel exacerb coliti	D003093;D014136;D001991	T047
36,320,033	pilot studi chcf genotyp pig challeng model enterotoxigen escherichia coli fabac associ post wean diarrhea host genotyp import enterotoxigen e coli etec suscept conduct two trial evalu effect chcf genotyp incid etec diarrhea trial n pig pig inocul cfu cfu dose etec fac strain trial n pig pig inocul etec fab fac across trial inocul pig develop etec diarrhea chcf heterozyg suscept inocul chcf homozyg resist pig develop etec diarrhea suscept toward etec facab infect might correspond chcf genotyp	D054307;D013553;D004927	T047;T007
36,320,031	compar analysi impact onlin blend face face learn medic student clinic compet affect cognit psychomotor domain coronavirus diseas covid pandem south africa compel medic school switch pure onlin curriculum innov chang transform standard clinic skill curriculum increas learn transfer bridg theori practic gap efficaci intervent remain unknown studi aim measur medic student clinic compet affect cognit psychomotor domain assess clinic skill knowledg retent transfer onlin platform compar face face blend learn	D013337;D000086382	T047;T067;T097
36,320,029	evalu hous staff candid program fit cohort base control studi medic school academ achiev necessarili predict hous staff job perform studi explor select mechan improv hous staff program fit enhanc accredit council graduat medic educ mileston perform rate	D007396	T065;T097
36,320,028	lp oxid phospholipid oxid specif epitop increas subject keloid format keloid format follow trauma surgeri common among dark pigment individu sinc lipoprotein lp postul putat role wound heal also mediat atherosclerot cardiovascular diseas assess whether lp associ oxid phospholipid oxid specif biomark associ keloid format	D000936;D010743	T129;T123;T116;T109
36,320,027	matern factor pregnanc influenc matern fetal childhood outcom enhanc pregnanc health known improv mother offspr life long well matern environ encompass genet factor impact social determin nutritionalmetabol milieu infect inflamm immedi consequ utero develop fetus long term program childhood adulthood moreov advers pregnanc outcom preterm birth preeclampsia often attribut matern environment factor list associ poor matern cardiometabol health pregnanc bmc medicin articl collect explor broad spectrum matern characterist across pregnanc postnat phenotyp anticip substanti cross fertil new understand share mechan around divers outcom advanc abil leverag omic across differ platform genom transcriptom proteom metabolom microbiom lipidom larg high dimension popul databas uniqu cohort generat excit new insight first articl collect highlight role placent biomark preterm birth metabol influenc fetal childhood growth impact common pre exist matern disord obes smoke pregnanc outcom child health collect grow look forward see connect emerg across matern fetal childhood outcom foster new insight prevent strategi women	D047928;D011225	T046
36,320,025	effect complementari music intervent patient qualiti life septoplasti rhinoplasti qualiti life qol assess emerg import evalu tool therapeut treatment posit impact complementari music intervent qol demonstr literatur particular chronic malign diseas howev benefit periop period head neck patient investig thus far	D012225;D009146;D009147;D015508	T061;T047;T170;T033
36,320,023	incid clinic characterist risk factor outcom patient mix candidabacteri bloodstream infect retrospect studi mix candidabacteri bloodstream infect mix cb bsis worthi particular attent recent analyz incid co pathogen clinic characterist risk factor outcom mix cb bsis compar monomicrobi candidemia mono candidemia adult patient china	D002177;D058387;D001424;D060085	T047
36,320,021	sleep disturb associ mild cognit impair communiti popul base cross section studi sleep conduc elimin brain metabolit recoveri brain function howev relationship sleep disturb mild cognit impair fulli determin	D060825;D012893	T047;T048
36,320,019	muscl strength associ fractur risk obtain fractur risk assess tool frax women breast cancer women breast cancer risk develop sarcopenia occurr fractur initi period screen condit prevent risk disabl poor qualiti life death present studi investig associ sarcopenia phenotyp fractur risk assess fractur risk assess tool frax women breast cancer	D055948;D006620;D009369	T047;T191;T037
36,320,018	evalu diurnal postur intracrani pressur employ telemetr monitor idiopath intracrani hypertens intracrani pressur icp thought vari diurnal studi evalu diurnal icp measur quantifi chang icp occur chang bodi postur activ idiopath intracrani hypertens iih	D007427;D011559	T047;T042
36,320,017	meat consumpt risk general central obes shahedieh studi studi aim investig relat total meat intak subtyp includ red process meat white meat poultri fish organ meat risk generalcentr obes	D056128;D009765	T033;T184;T047
36,320,016	influenc artifici saliva clean forc interdent rubber pick vitro comparison familiar aid interdent clean dental floss interdent brush idb often associ difficult handl increas potenti trauma interdent pick irp metal core silicon flap instead nylon brush offer altern howev vitro studi found lower clean effect combin higher forc clean compar convent idb aim vitro studi measur experiment clean forc ecf use irp versus without artifici saliva gum hydral sunstar suiss sa etoy switzerland	D003742;D003773	T047;T074;T073
36,320,015	counti level associ food retail avail violent crime rate violent crime ie homicid arm robberi aggrav assault rape continu major public health concern america sever studi link avail densiti specif featur retail food environ conveni store liquor store violent crime rate due crimin activ often occur near retail nevertheless continu limit understand featur eg groceri store supercent restaur etc associ violent crime occurr studi aim fill gap knowledg examin us counti level associ food retail avail violent crime rate	D012111;D003132	T078;T082;T083;T033;T056;T096;T097;T081;T057
36,320,014	small nodul mm diamet multipl primari lung cancer preval manag synchron multipl primari lung cancer associ small non domin nodul common encount howev incid follow treatment small non domin tumor littl studi explor preval manag small non domin tumor factor associ interv growth	D055613;D008175;D009378;D003074	T033;T047;T191
36,320,013	occup industri specif cancer mortal among japanes women number women japan continu work childbirth rise past year japan cancer mortal rate increas cancer death among japanes women age caus lung gastric pancreat colorect cancer studi aim examin differ mortal risk key cancer among women explor effect econom crisi mid separ occup industri categori	D009790;D009369	T090;T191;T057
36,320,012	investig causal relationship al autoimmun disord mendelian random studi epidemiolog studi report associ amyotroph later sclerosi al differ autoimmun disord studi aim explor causal relationship autoimmun disord al use mendelian random mr	D000690;D001327	T047
36,320,011	gender relat factor associ delay diagnosi tuberculosi eastern europ central asia tuberculosi tb prevent treatabl diseas year affect million peopl take million live recogn symptom obtain correct diagnosi vital step toward treatment cure time person tb get diagnos may influenc biolog differ sex factor link person gender context prevail gender norm accord hypothesi gender relat factor contribut delay diagnosi tb investig four countri georgia kazakhstan republ moldova tajikistan eastern europ central asia eeca region high burden drug resist tb scarciti gender relat tb inform vari gender equal retrospect inform collect direct peopl histori tb depth interview focus group discuss find differ gender way particip recogn tb symptom three countri women de priorit seek diagnosi lack access financ household relat oblig four countri men tradit carri weight econom support famili tend postpon tb diagnosi two countri women experienc stigma often men deterr factor seek healthcar role gender obtain correct diagnosi came forth among respond georgia extent kazakhstan conclud barrier health care seek tb diagnosi affect differ women men gender divers person eeca region	D014376;D018088	T047
36,320,010	predict violenc male schizophrenia use smri base machin learn algorithm violent behavior patient schizophrenia scz major social problem earli identif scz patient violenc facilit implement target intervent	D012559	T048
36,320,008	high tumor hexokinas express promot pro tumorigen immun microenviron modul cdregulatori cell infiltr relationship cancer cell glycolysi landscap tumor immun microenviron human cancer investig	D002289;D008175;D000077192;D002294	T191
36,320,007	preval patholog equin parvovirus hepat racehors new york racetrack theiler diseas aka equin serum hepat devast high fatal diseas hors equin parvovirus hepat eqpv h identifi like caus diseas incid theiler diseas low preval eqpv h dna hors high region suggest subclin persist infect common	D006734;D006524;D017992;D019219;D006505	T047;T005
36,320,006	comprehens analysi express prognosi iq motif contain gtpase activ protein hepatocellular carcinoma iq motif contain gtpase activ protein iqgap group scaffold protein identifi involv tumor initi progress divers type cancer clinic studi experiment evid suggest iqgap play essenti role hepatocellular carcinoma hcc progress alter express close relat patient prognosi howev differ express pattern prognost valu three iqgap isoform hcc yet analyz simultan	D006528;D008113	T191
36,320,005	qualit inquiri percept hiv pre exposur prophylaxi among peopl inject drug live hepat c seattl wa usa incid hiv among person inject drug pwid usa increas sinc signal need identifi effect way engag pwid hiv prevent servic name pre exposur prophylaxi prep yet uptak prep popul minim compar popul risk hiv acquisit work sought explor knowledg attitud perspect prep accept among pwid	D065129;D015819;D055030;D019380;D015658;D006526	T061;T121;T098;T033;T047;T101;T048
36,320,004	preval factor associ depress among older adult case low incom countri ethiopia systemat review meta analysi depress among common mental health problem late life import public health problem studi middl high incom countri shown depress common among older peopl adolesc mani older peopl depress overlook fewer effort made mitig suffer despit depress major public health problem among older adult overal magnitud main predictor determin develop appropri measur henc object studi therefor estim overal preval depress identifi predictor among older adult ethiopia	D003863;D011203	T184;T098;T102;T064;T048
36,320,003	psoriasi cardiovascular diseas risk european east asian popul evid meta analysi mendelian random analysi psoriasi link cardiovascular diseas cvd includ coronari arteri diseas cad myocardi infarct mi heart failur hf howev avail studi regard relationship shown inconsist result therefor report perform comprehens review literatur assess effect psoriasi risk cvds	D002318;D003324;D009203;D011565	T047
36,320,002	conserv surgeri microwav ablat recurr bone tumor extrem singl center studi surgic treatment recurr bone tumor extrem still present challeng studi design evalu clinic valu microwav ablat treatment recurr bone tumor	D008872;D001859	T070;T191;T057
36,320,001	impact covid pandem anxieti depress among physic therapist saudi arabia cross section studi physic therapist may becom infect treat patient sinc direct contact within two meter radius addit physic therapist may feel suscept covid infect appli rehabilit practic often involv direct contact patient physic therapist survey level anxieti depress due coronavirus diseas pandem covid	D000086382;D059825	T047;T097;T067
36,320,000	associ alcohol use memori declin middl age older chines longitudin cohort studi previous studi associ alcohol use memori declin show inconclus result examin associ use longitudin data guangzhou biobank cohort studi gbcs explor whether associ vari sex age group	D000428;D008569	T055;T184;T048
36,319,999	comparison effect anchor needl coil local multipl nodul lung recent new type pulmonari nodul posit needl adopt clinic aim evalu efficaci safeti new type local needl compar coil simultan local multipl pulmonari nodul guid comput tomographi ct prior video assist thoracoscop surgeri vat	D055613;D003074;D008175	T033;T047;T191
36,319,998	nk cell solid tumor therapeut potenti persist obstacl natur killer nk cell innat lymphocyt endow potent cytotox activ recent attract attent potenti anticanc therapeut nk cell mediat encourag respons patient leukemia therapeut effect nk cell infus patient solid tumor limit preclin clinic data suggest efficaci nk cell infus solid malign hamper sever factor includ inadequ tumor infiltr persistenceactiv tumor microenviron tme number metabol featur tme includ hypoxia well elev level adenosin reactiv oxygen speci prostaglandin negat affect nk cell activ moreov cancer associ fibroblast tumor associ macrophag myeloid deriv suppressor cell regulatori cell activ suppress nk cell depend anticanc immun review metabol cellular barrier inhibit nk cell solid neoplasm discuss potenti strategi circumv obstacl toward superior therapeut activ	D009369;D000072737	T191;T025
36,319,997	user make judgement qualiti onlin health inform cross section survey studi peopl increas use internet seek health inform howev overal qualiti onlin health inform remain low situat exacerb unpreced infodem negat consequ patient therefor import understand user make judgement health inform appli differ judgement criteria	D057220;D017216	T058;T041
36,319,996	magnitud diabet peripher neuropathi saudi arabia systemat review meta analysi diabet peripher neuropathi dpn due potenti caus morbid disabl foot ulcer amput increas becom sourc concern saudi arabia worldwid howev wide variabl exist preval dpn report previous studi saudi arabia limit util exist data nation public health polici therefor aim studi systemat evalu magnitud dpn patient live dm saudi arabia order inform policymak implement appropri prevent treatment strategi dpn	D003929;D003920	T047
36,319,995	spatiotempor analysi sever fever thrombocytopenia syndrom shandong provinc china due recent emerg sever fever thrombocytopenia syndrom sfts becom one major public health problem shandong provinc china number report sfts case general area report sfts case continu increas recent year howev spatiotempor pattern cluster sfts shandong provinc investig yet	D000085142	T047
36,319,994	heal effect monom dimer resveratrol mous periodont model antioxid anti inflammatori effect resveratrol report previous particular monomer tran resveratrol demonstr produc posit effect various patholog process report previous resveratrol dimer rich melinjo extract among other caus bone heal decreas local oxid damag activ antioxid nuclear factor erythroid relat factor nrf pathway mous model experiment induc periodont ep studi aim compar bone heal effect resveratrol monom resveratrol dimer gnetin c found melinjo seed extract model ep investig involv nrf effect either form resveratrol	D010518;D016301	T047
36,319,993	general paediatr dentist knowledg attitud practis regard use silver diammin fluorid manag dental cari nation survey netherland silver diammin fluorid sdf topic medic use arrest cavit carious lesion non invas primari aim investig analys relationship knowledg attitud practis includ barrier facilit sdf use manag dental cari general dental practition gdps paediatr dentist pds netherland secondari aim explor differ group	D003815;D003731	T033;T047;T097
36,319,992	warburg effect colorect cancer emerg role tumor microenviron therapeut implic colorect cancer crc third common cancer second lead caus cancer relat death worldwid countless crc patient undergo diseas progress hallmark cancer warburg effect promot cancer metastasi remodel tumor microenviron includ promot angiogenesi immun suppress cancer associ fibroblast format drug resist target warburg metabol would promis method treatment crc review summar inform role warburg effect tumor microenviron elucid mechan govern warburg effect crc identifi novel target therapi	D015179;D000072645	T191;T025
36,319,991	magnitud common mental disord associ factor among patient epilepsi amhara region state northwest ethiopia common mental disord sever frequent co morbid psychiatr ill epilepsi differ studi find across world show patient epilepsi higher burden mental disord general popul howev issu patient epilepsi consist undiagnos	D001523;D004827	T033;T047;T048
36,319,990	effect local tailor intervent uptak preconcept care netherland step wedg cluster random trial apropo ii studi preconcept period provid window opportun intervent aim reduc unhealthi lifestyl behaviour negat effect pregnanc outcom studi aim assess effect local tailor preconcept care pcc intervent hybrid ii effect implement design	D016742;D008019	T058;T054;T047
36,319,988	dietari intak yogurt chees children age year sleep durat age year japan environ children studi previous report year old infant born mother regular consum ferment food pregnanc lower risk sleep depriv howev known posit effect enhanc infant eat ferment food long term effect consumpt studi examin associ frequenc ferment food intak child wean period sleep depriv age year	D015014;D002611	T168
36,319,987	paradox breast cancer incid mortal two corner europ breast cancer incid rise global mortal rate show geograph heterogen pattern earli detect treatment proven profound impact breast cancer prognosi aim studi compar breast cancer incid mortal surviv rate two contrast corner europ sweden crete better understand cancer determin focus diseas burden sociocultur factor	D001943	T191
36,319,986	prognost valu high sensit cardiac troponin earli coronari arteri bypass graft surgeri diagnosi periprocedur myocardi infarct pmi coronari arteri bypass graft cabg base biochem marker along clinic instrument find howev clear cutoff valu high sensit cardiac troponin hs ctn identifi pmi hypothes isol hs ctn concentr first h follow cabg could predict cardiac advers event hospit death pmi andor left ventricular eject fraction lvef decreas	D019210;D009203	T123;T047;T116
36,319,985	prognost valu combin mtv adc deriv baselin fdg petmri aggress non hodgkin lymphoma aim prospect studi investig prognost valu metabol tumor volum mtv appar diffus coeffici adc baselin fdg petmri compar establish clinic risk factor term progress free surviv pfs year cohort diffus larg b cell lymphoma dlbcl high grade b cell lymphoma hgbcl	D008228;D016403	T191
36,319,982	employe healthi eat physic activ role colleagu encourag behaviour exercis eat healthi individu choic influenc famili member friend neighbour littl known howev colleagu anoth import interperson influenc mani peopl spend mani hour work surround most colleagu could therefor signific shape employe un healthi choic studi extent colleagu may play part one anoth eat exercis behaviour focus two pathway colleagu encourag healthi lifestyl act role model whose behaviour observ copi	D000072001;D016272	T061;T078;T091;T055;T033
36,319,981	implement fidel brazilian drug use prevent program effect among adolesc mix method studi base us dare kir version keepin real program drug violenc resist educ program proerd wide implement brazilian prevent program origin translat dare kir version keepin real program previous result suggest ineffici prevent drug use among brazilian adolesc sinc kir fidel impact program outcom mix method studi evalu proerd implement fidel effect prevent drug use among adolesc	D012572;D019966	T033;T058;T048
36,319,980	unlik oxygen supplement copd patient chronic respiratori failur reduc cardiac troponin level cardiac troponin ctnt biomark myocardi injuri frequent elev copd patient potenti hypoxemia non randomis observ studi investig whether long term oxygen treatment ltot reduc ctnt level	D029424;D000142	T047
36,319,979	view hong kong parent secondari use dri blood spot newborn screen program residu dri blood spot rdbs newborn screen programm repres valuabl resourc medic research basic scienc clinic public health hong kong legisl biobank parent view retent use residu newborn blood sampl could cultur specif import consid biobank rdbs	D015997;D018070	T061;T093
36,319,978	indoleamin dioxygenas immunohistochem express medullari thyroid carcinoma implic prognosi immunomodulatori effect linkag ido express cancer progress still unclear particular medullari thyroid carcinoma mtc purpos unveil potenti correl ido status clinic patholog paramet patient prognosi possibl immunomodulatori function mtc	D013964;D018278	T191

36,320,187

factor affect need postop blood transfus elder patient intertrochanter hip fractur investig risk factor increas frequenc blood transfus elder patient intertrochanter hip fractur determin blood transfus risk surgeri take select precautionari measur group high risk transfus ensur safe surgeri

D006620

T037

36,320,153

earli onset senesc imbalanc epiderm homeostasi across decad photoexpos human skin fingerprint inflammag inflammag theori age purport low level chronic inflamm lead cellular dysfunct prematur age surround tissu skin suscept inflammag first line defenc environ particular solar radiat better understand impact age photoexposur epiderm biolog perform system biolog base analysi photoexpos face arm photoprotect buttock site women age biopsi analys histolog transcriptom proteom skin surfac biomark collect tape strip identifi morpholog chang age epiderm thin rete ridg pathlength loss stratum corneum thicken sasp biomark il il rail consist elev face across age cistran urocan acid elev arm face age older arm dna damag respons biomark bp show higher puncti number basal layer epigenet age acceler gene associ differenti senesc show increas express wherea gene associ hypoxia glycolysi increas proteom compar vs confirm elev level differenti glycolyt relat protein repres immunostain protein differenti senesc oxygen sensinghypoxia show similar relationship system biolog base analysi provid bodi evid young photoexpos skin undergo inflammag propos presenc chronic inflamm young skin contribut imbal epiderm homeostasi lead prematur age appear later life

D004817;D012867

T022;T024

36,320,146

system sclerosi cerebr infarct sever stenosi intern carotid arteri coronari arteri case report system sclerosi ssc chronic autoimmun diseas character microangiopathi extens fibrosi autoantibodi product general believ microvascular diseas hallmark ssc macrovascular involv initi consid featur ssc mortal high ignor present ssc patient cerebr involv multipl macrovascular stenosi rare describ herein report case cerebr infarct sever stenosi intern carotid arteri coronari arteri associ ssc

D002343;D012595

T023;T047

36,320,141

unexplain abdomin pain caus fractur thorac vertebra background import identifi caus chronic abdomin pain especi older adult thoracolumbar vertebr compress fractur one potenti caus difficult identifi report case older man sever unexplain abdomin pain nausea due inadequ treat thoracolumbar vertebr compress fractur case report year old man fell day prior visit hospit diagnos compress fractur th vertebra start wear corset day injuri two day later develop abdomin pain mild nausea decreas appetit attribut symptom wear corset therefor stop wear caus abdomin symptom could determin blood test comput tomographi abdomen upper bodi elev induc mark right lower abdomin pain consist domin region th l decreas temperatur sensat observ region conclud abdomin pain caus neuropathi owe ruptur th vertebr fractur patient treat conserv abdomin pain nausea resolv week admiss patient discharg conclus assess patient unexplain abdomin pain vertebr compress fractur includ differenti diagnosi necessari diagnost assess made earli possibl earli diagnosi provid wider rang treatment option contribut minim function declin

D050815;D016103

T046;T037

36,320,129

influenc surfac type coffe immers surfac topographi optic mechan properti select ceram materi background aim studi assess compar effect surfac type glaze polish coffe immers age surfac topographi ra optic properti tp op mechan properti fractur forc mode zirconia reinforc lithium silic vita suprin hybrid polym infiltr feldspath ceram network materi vita enam leucit contain feldspath glass vitabloc mark ii made comput aid design comput aid manufactur cadcam ceram materi materi method fifti four specimen assembl cadcam ceram materi group divid glaze polish surfac specimen everi type stain coffe day ra color specimen form tp op record immers stain materi fractur forc mode analyz day age data analyz use anova post hoc analysi bonferroni test result studi found signific differ ra tp op coffe immers glaze polish specimen higher valu polish surfac among ceram materi highest valu fractur resist note vita suprin vita enam lowest valu without signific differ among group conclus tp op valu accept clinic rang vita suprin superior tp group repar fractur type observ vita suprin wherea semi repar non repar predomin group

D003069;D007101

T060;T168;T037

36,320,118

circul cell free messeng rna enabl non invas pan tumour monitor melanoma therapi independ mutat genotyp plasma deriv tumour specif cell free nucleic acid increas util minim invas real time biomark approach mani solid tumour circul tumour dna melanoma specif mutat current best studi liquid biopsi biomark melanoma howev combin hotspot genet alter cover around melanoma patient therefor altern approach need enabl follow genotyp includ wild type

D008545;D000073888;D009506

T123;T191;T114

36,320,115

phylogenet characterist fasciola hepatica isol korean patient fascioliasi parasit infect caus liver fluke although sever case report korea phylogenet analysi isol lack studi year old woman right upper quadrant ruq abdomin pain diagnos fascioliasi involv abdomin muscl imag studi receiv praziquantel treatment symptom improv later movement abscess lesion follow trematod parasit surgic remov patient rectus abdomini muscl fluke identifi fasciola hepatica base sequenc analysi rdna determin phylogenet posit fasciola strain name korean fasciola kf cox gene bp analyz compar gene f hepatica strain isol cow sheep goat human various countri phylogenet analysi show kf close relat isol china goat

D005210;D005211;D005209;D012757

T047;T204

36,320,114

alaria alata digenea diplostomida korean raccoon dog nyctereut procyonoid koreensi korea report speci diplostomid fluke recov carcass wild korean raccoon dog nyctereut procyonoid koreensi korea total diplostomid fluke recov small intestin korean raccoon dog obtain gangwon wildlif medic rescu center worm fix neutral formalin subject microscop observ fix ethanol use molecular genom analysi worm divid separ part forebodi hindbodi total length width boat shape forebodi pair characterist tentacular appendag sucker holdfast organ vitellin follicl oval cylindr hindbodi reproduct organ ovari round ellipt locat anterior test two larg test slight segment tandem arrang occupi almost half hindbodi short uterus contain relat small number unembryon egg size partial sequenc rrna fluke consist alaria alata base morpholog molecular characterist diplostomid fluke recov small intestin korean raccoon dog identifi alata digenea diplostomida

D046031;D014200

T015;T204

36,320,113

excretori secretori product trichomona vaginali caus apoptosi mous sperm vitro excretori secretori product esp vaginali shown inhibit sperm motil viabil function integr lead decreas fertil rate vitro studi investig whether vaginali induc apoptosi ultrastructur chang sperm use flow cytometri electron microscopi incub sperm vaginali esp increas phosphatidylserin extern dna fragment decreas mitochondri membran potenti transmiss electron microscopi sperm incub esp reveal abnorm featur distort head broken neck acrosom exocytosi first report demonstr direct impact vaginali esp sperm apoptosi architectur vitro

D014246

T204

36,320,112

cerebr paragonimiasi present dementia report case year old korean man chronic cerebr paragonimiasi present progress memori impair suffer pulmonari paragonimiasi year ago experienc epilepsi sinc age began experienc memori cognit deterior year ago visit neuropsychiatr depart hospit check symptom health year ago contrast enhanc brain magnet reson imag studi reveal calcif cystic lesion encompass right temporo occipit region encephalomalat chang also observ right occipit tempor area anti paragonimus specif igg antibodi serum show strong posit respons neuropsycholog test result show global deterior scale clinic dementia rate scale chronic cerebr paragonimiasi lesion patient right temporo occipit region might induc dement chang

D010237;D010238;D003704

T047;T204;T048

36,320,111

biolog characterist recombin arthrobotri oligospora chitinas ao chitinas ao hydrolas secret arthrobotri oligospora nematod feed role remain elus studi analyz molecular characterist recombin chitinas arthrobotri oligospora reao ao belong typic glycosid hydrolas famili conserv chitinas sequenc tertiari structur trios phosphat isomeras tim barrel molecular weight reao kda reao effect degrad colloid powder chitin egg lysat stage larval lysat caenorhabd elegan activ reao reach peak c ph valu enzym activ inhibit zn ca fe wherea mg k potenti activ addit urea sodium dodecyl sulfat mercaptoethanol signific inhibit enzym activ reao show complet nematicid activ c elegan stage larva reao broke c elegan egg shell caus die die prematur hatch egg also invok degrad haemonchus contortus egg result appar chang morpholog structur studi demonstr cytotox effect reao laid foundat dissect mechan nematod infest oligospora

D002688;D001203;D009348

T004;T126;T116;T204

36,320,110

antimalari efficaci aqueous extract strychno ligustrina combin dihydroartemisinin piperaquin phosphat dhp plasmodium berghei infect develop drug resist one sever concern malaria control increas risk malaria morbid death new candid drug antiplasmodi activ urgent need studi evalu efficaci differ dosag aqueous extract strychno ligustrina combin dihydroartemisinin piperaquin phosphat dhp murin plasmodium berghei infect balbc mice age week divid group consist mice growth inhibit compound p berghei monitor calcul percentag parasitemia result show mice receiv aqueous extract combin treatment show growth inhibit p berghei respect ligustrina extract consist brucin strychnin effect inhibit multipl p berghei treat mice show improv hematolog profil bodi weight temperatur compar control mice co treatment ligustrina extract dhp reveal signific antimalari antipyret effect result provid prospect discoveri antimalari drug may show success chemotherapeut treatment

D000962;D031451;D008288;D037621

T121;T047;T002;T109

36,320,109

spatiotempor cluster trend pneumocysti pneumonia korea studi determin recent status trend pneumocysti jirovecii pneumonia pcp non human immunodefici virus hiv non hiv pcp hiv hiv pcp infect popul use data health insur review assess servic hira korea diseas control prevent agenc kdca satscan joinpoint use statist analys non hiv pcp case show upward trend studi period largest number case upward trend similar adjust popul seoul highest number case non hiv pcp group adjust popul case follow jeju case like cluster mlc non hiv pcp group seoul relat risk rr log likelihood ratio llr follow jeju rr llr upward trend observ among non hiv pcp group jeju dojeollanam dojeollabuk dogyeongsangnam dobusandaejeondaeguulsan joint cluster llr p locat southern part korea women men non hiv group show overal upward trend pcp studi period men age group highest annual percentag chang apc contrast hiv group show fall trend pcp recent men age group decreas apc studi provid analyt basi health measur nationwid epidemiolog surveil system manag pcp

D045363;D011020;D015658

T047;T004

36,320,108

hypoxia induc factor alpha stabil human macrophag leishmania major infect impair parasit virul hypoxia induc factor alpha hif one master regul immun metabol cellular function hif transcript factor whose activ close relat oxygen level target understand infecti diseas control sever studi demonstr hif play import role infecti process role relat parasit virul address work studi express level hif relat angiogen vascular endotheli growth factor vegf human macrophag infect promastigot hypo hyper virul leishmania major human isol l major parasit readili subvert host macrophag function surviv induc local oxygen consumpt site infect contrast hypo virul parasit induc high hif express level hyper virul l major reduc hif express macrophag normox hypox condit consequ imped express vegf mrna hif may play key role control diseas chronic sever outcom

D018320;D010271;D007896

T047;T204

36,320,107

treatment extracellular vesicl giardia lamblia allevi dextran sulfat sodium induc coliti cbl mice inflammatori bowel diseas ibd chronic recurr ill gastrointestin tract treatment ibd tradit involv use aminosalicyl acid steroid drug associ untoward effect refractori absenc effect treatment regimen ibd led explor new target parasit promis altern therapi ibd recent studi highlight use parasit deriv substanc excretori secretori product extracellular vesicl ev exosom treatment ibd report examin whether ev secret giardia lamblia could prevent coliti mous model g lamblia ev glev prepar vitro cultur giardia trophozoit clinic sign microscop colon tissu inflamm cytokin express level detect assess effect glev treatment dextran sulfat sodium dss induc experiment murin coliti administr glev prior dss challeng reduc express level pro inflammatori cytokin includ tumor necrosi factor alpha interleukin beta interferon gamma result indic glev exert prevent effect possess therapeut properti dss induc coliti

D016829;D003092;D015212;D000067128

T026;T047;T204

36,320,090

oxid stress respons small extracellular vesicl microrna age relat macular degener biomark therapeut tool age relat macular degener amd main caus blur vision oxid stress lead risk factor amd patholog small extracellular vesicl ev nm membran microvesicl mvs releas sever cell type control fashion transfer cell cell mediat diseas progress ev encapsul transfer microrna mirna recipi cell mirna small non code rna molecul inhibit express function target mrnas mirnamrna interact conserv utr region way modul varieti physiolog patholog process dysregul ev mirna cargo retin cell believ correl loss cellular homeostasi amd patholog review investig associ oxid stress sev mirna amd pathogenesi potenti discov novel treatment target amd

D035683;D008268;D000067128

T026;T123;T047;T114

36,320,089

connect earli life advers post traumat stress disord updat review human be develop high coordin flexibl system social behavior threat evalu review focus uniqu role earli life advers ela program deficit social behavior threat process provid guidanc futur investig area stress reactiv mental health propos neuroendocrin perturb hypothalamus pituitari adren hpa axi gene activ epigenet mechan may explain earli advers circumst may lead post traumat stress disord ptsd detail explor interact stress environment factor epigenet genet regul hpa axi may improv target intervent among vulner individu convinc studi follow direct contribut effect prevent treatment ptsd earli traumat patient

D013313;D000076783

T033;T048

36,320,087

flecainid induc pneumon case report report case acut respiratori distress associ histolog pattern acut fibrin organ pneumonia discuss possibl respons flecainid therapi

D011014;D018549

T047;T050

36,320,086

presum bietti crystallin dystrophi optic nerv head drusen case report bietti crystallin dystrophi primarili retin dystrophi caus cypv mutat typic present crystallin retin deposit posterior fundus

D009898;D015594;D012162

T033;T023;T046;T047

36,320,085

differenti hypomethyl cell free dna coronari collater circul factor affect cardioprotect collater circul still incomplet understood recent characterist cpg methyl cell free dna cfdna report marker clinic util aim studi evalu whether cfdna methyl pattern associ grade coronari collater circul ccc

D000073888;D003324

T123;T047;T114

36,320,082

diagnost util csf immunohistochemistri tenosynovi giant cell tumor differenti giant cell rich tumor tumor like lesion bone soft tissu tenosynovi giant cell tumor tsgct benign fibrohistiocyt tumor affect synovium joint bursa tendon sheath categor local tsgct ltsgct diffus tsgct dtsgct ltsgct dtsgct character recurr fusion involv coloni stimul factor csf gene transloc partner collagen type vi alpha chain fusion gene induc intratumor overexpress csf mrna csf protein csf express characterist find tsgct detect csf mrna csf protein may use patholog diagnosi although effect anti csf antibodi date situ hybrid ish csf mrna perform detect csf express tsgct perform csf immunohistochemistri ihc use anti csf antibodi clone case tsgct giant cell rich tumor gcrt gcrt like lesion verifi util patholog diagnosi tsgct

D000070779;D005870

T191

36,320,080

continu field flood versus final one shot co insuffl minim invas mitral valv repair insuffl carbon dioxid co oper field prevent cerebr myocardi damag air embol well known strategi open heart surgeri howev general consensus best deliveri approach

D007327;D006348

T061;T058

36,320,078

person characterist associ satisfact healthcar wish complain increas evid satisfact healthcar complaint rate vari patient socio demograph characterist likewis patient person might influenc percept health care howev empir research scarc aim studi investig associ health care user person satisfact care urg complain

D010549;D010551

T033;T041

36,320,077

prophylact antibiot use labor deliveri china nationwid multicent hospit base cross section studi prophylact antibiot use deliveri common routin obstetr practic prevent infect global especi low middl incom countri china howev littl current known nation estim prophylact antibiot use deliveri therefor aim describ preval prophylact antibiot use guidelin adher use nation data china

D007743;D011248

T040;T046

36,320,076

combin impact persist infect human genet variat c reactiv protein level multipl human pathogen establish chronic sometim life long infect even often latent infect trigger degre local system immun respons result chronic low grade inflamm remain incomplet understand potenti contribut persist infect human genet variat chronic low grade inflamm search potenti associ seroposit persist pathogen plasma level inflammatori biomark c reactiv protein crp use data collect context uk biobank colauspsycolaus studi two larg popul base cohort perform backward stepwis regress start follow potenti predictor serostatus pathogen polygen risk score crp demograph clinic factor known associ crp found evid associ chlamydia trachomati p valu e helicobact pylori p valu e seroposit higher plasma level crp also found associ pathogen burden crp level p valu e result improv understand relationship persist infect chronic inflamm import determin long term morbid human

D016481

T047

36,320,074

role biomark diagnosi invas aspergillosi immunocompromis patient invas aspergillosi one import caus infect immunocompromis patient studi aim evalu role biomark diagnosi invas aspergillosi relationship antifung stewardship program

D001228;D000072742

T047

36,320,073

impair traffick instabl mutant kidney anion exchang protein associ autosom recess distal renal tubular acidosi mutat solut carrier famili member slca encod anion exchang ae common caus autosom recess distal renal tubular acidosi ar drta southeast asian explain molecular mechan diseas hematolog abnorm affect famili conduct genet analysi slca studi wild type mutant ae protein express human embryon kidney hekt cell

D001457;D007668

T123;T023;T116

36,320,072

b h target car cell show high effici anti tumor function osteosarcoma vitro vivo osteosarcoma os main happen children youth surgeri radiotherapi chemotherapi common therapi osteosarcoma treatment anti tumor effect limit recent year new cellular therapi car cellular immunotherapi genet engin cell bear chimer antigen receptor target specif tumor associ antigen prove effect therapi acut lymphoblast leukemia thus car potenti effect therapi osteosarcoma treatment

D000076962;D012516;D001859

T129;T191;T116;T192

36,320,071

summaris data factor associ covid relat conspiraci theori first year pandem systemat review narrat synthesi conspiraci theori particular harm effect negat shape health relat behaviour signific number covid specif conspiraci theori emerg immedi aftermath pandem outbreak aim studi systemat review literatur conspiraci theori relat covid first year pandem identifi preval determin public health consequ comprehens literatur search carri pubm psycinfo detect studi examin conspiraci theori relat covid januari st januari th forti three studi includ total particip particip agre least one conspiraci belief certain sociodemograph factor young age femal gender non white lower socioeconom status psycholog aspect pessim blame other anger qualiti polit conservat religios mistrust scienc use social media sourc inform associ increas accept conspiraci theori conspiraci belief led harm health relat behaviour pose serious public health threat larg scale collabor govern healthcar organ need curb spread conspiraci theori advers consequ

D000086382;D061108

T047;T170;T067

36,320,068

transgen anim model explor modul blood brain blood retin barrier cns uniqu environ brain retina tight regul blood brain barrier blood retin barrier respect ensur proper neuron function endotheli cell within tissu possess distinct properti allow control passag solut fluid pericyt glia cell neuron signal endotheli cell ec form maintain barrier control blood flow help creat neurovascular unit barrier lost wide rang diseas affect central nervous system cns retina brain tumor stroke dementia eye diabet retinopathi retin vein occlus age relat macular degener name promin exampl recent studi direct link barrier chang promot diseas patholog degrad neuron function understand barrier form restor barrier diseas provid import point therapeut intervent review aim describ fundament blood tissu barrier cns use transgen anim model led current understand molecular framework barrier review also highlight exampl target barrier properti protect neuron function diseas state

D001813;D001812

T023;T042

36,320,066

popul base estim correl oncotyp dx breast recurr score result ki ihc mib pharmdx hr node posit earli breast cancer unit state food drug administr recent approv ki immunohistochemistri ihc assay identifi patient earli breast cancer high diseas recurr risk oncotyp dx breast recurr score assay valid hormon receptor posit hr human epiderm growth factor receptor negat invas breast cancer ibc predict chemotherapi benefit distant recurr risk regardless nodal status studi assess correl recurr score rs result ki ihc mib pharmdx assay

D001943

T191

36,320,063

alter dna methyl express gene relat thyroid hormon metabol colon epithelium obes patient colorect cancer common among obes individu purpos current studi determin chang dna methyl status mrna express thyroid hormon receptor beta thrb tumor suppressor thyroid hormon inactiv enzym type deiodinas dio gene human epitheli colon tissu healthi obes individu

D019175;D037042

T116;T044;T192

36,320,062

turkish spanish pakistani medic student valu specialti train posit discret choic experi aim studi find specialti train prefer senior medic student three medic school turkey spain pakistan

D013337

T097

36,320,061

bayesian spatio tempor model map malaria anaemia among children month nigeria vital aspect diseas manag polici make lie understand univers distribut diseas nevertheless due differ host group space time outbreak activ data subject intricaci herein bayesian spatio tempor model propos model map malaria anaemia risk ratio space time well ascertain risk factor relat diseas endem state nigeria paramet estim perform employ r integr nest laplac approxim inla packag devianc inform criteria appli select best model

D008288;D000740

T047

36,320,060

associ abdomin obes indic risk cardiovascular event chines popul type diabet prospect cohort studi waist circumfer wc viscer adipos index vai lipid accumul product lap chines viscer adipos index cvai consid surrog indic abdomin fat deposit longitudin associ indic cardiovascular cv event adult type diabet td remain unclear studi aim examin associ abdomin obes indic incid cv event among peopl td compar predict perform risk assess

D003924;D002318

T047

36,320,059

presenc impact multimorbid cluster advers outcom across spectrum kidney function multimorbid presenc two chronic condit common amongst peopl chronic kidney diseas unclear condit cluster togeth chang kidney function declin explor cluster condit associ differ estim glomerular filtrat rate egfr studi associ cluster advers outcom

D059350;D051436;D001281;D006333

T184;T047;T046

36,320,058

non adjust surgeri acut acquir comit esotropia general anesthesia investig surgic result non adjust sutur techniqu general anesthesia correct acut acquir comit esotropia

D004948

T047

36,320,057

qualit studi gender inequ gender base violenc nepal gender inequ violenc mutual exclus phenomena complex loop affect women nepal face sever inequ violenc caus divers result due social assign lower posit women hierarchi base power make women face subordin violenc nepal studi aim explor particip understand experi identifi status inequ women violenc emerg one consequ furthermor explor caus sex traffick exampl outcom inequ violenc

D000074386

T033;T048

36,320,056

exosom biogenesi machineri regul therapeut implic cancer exosom well known key mediat intercellular communic contribut various physiolog patholog process biogenesi involv four key step includ cargo sort mvb format matur transport mvbs mvb fusion plasma membran process modul competit coordin multipl mechan wherebi divers repertoir molecular cargo sort distinct subpopul exosom result high heterogen exosom intrigu cancer cell exploit various strategi aberr gene express posttransl modif alter signal pathway regul biogenesi composit eventu function exosom promot cancer progress therefor exosom biogenesi target therapi activ explor review systemat summar recent progress understand machineri exosom biogenesi regul context cancer particular highlight pharmacolog target exosom biogenesi promis cancer therapeut strategi

D055354;D009369

T026;T191

36,320,055

forthcom complic recov covid patient copd asthma possibl therapeut opportun infect sever acut respiratori syndrom coronavirus sar cov grow swift worldwid patient background chronic pulmonari inflamm asthma chronic obstruct pulmonari diseas copd like infect virus note argument covid remain serious complic like fibrosi patholog chang pulmonari tissu patient chronic diseas along convent medic regen medicin cell base therapi could altern approach compens organ loss restor injur site use differ stem cell type owe uniqu differenti capac paracrin activ cell acceler heal procedur review articl tri scrutin differ report relat harm effect sar cov patient asthma copd well possibl therapeut effect stem cell allevi post covid complic video abstract

D000086382;D029424;D001249

T047;T067

36,320,054

de novo mutat within metabol network amino acidproteinenergi chines autist children intellectu disabl autism spectrum disord asd often accompani intellectu disabl id despit extens studi howev genet basi comorbid still clear studi tri develop analyz pipelin de novo mutat possibl pathway relat id phenotyp asd whole exom sequenc wes perform screen de novo mutat candid gene asd children togeth parent trio de novo alter gene relat pathway associ id phenotyp analyz connect node gene pathway select diagnost valu select gene id phenotyp studi popul also evalu

D000067877;D001321;D008607

T048

36,320,053

correl map genom wide dna methyl pattern pair human brain buccal sampl epigenom wide associ studi ewa assess link dna methyl dnam phenotyp relat structur brain measur cognit function neurodegen diseas becom increas popular due inaccess brain tissu human sever studi use peripher tissu blood buccal swab saliva surrog aid function interpret ewa find set need assess correl dnam variabl across tissu individu studi perform correl analysi dnam data total n match post mortem buccal prefront cortex sampl identifi near approxim cytosin phosphat guanin cpg site show signific fals discoveri rate q correl buccal pfc sampl correl cpg site show preponder locat promot region show signific enrich determin genet factor ie methyl quantit trait loci mqtl base buccal dorsolater prefront cortex mqtl databas novel buccal brain dnam correl map provid valuabl resourc futur ewa use buccal sampl studi dnam effect phenotyp relat brain correl result made freeli avail public onlin

D019175;D040641

T028;T044

36,320,048

relaps problem drink trade spirit use us nation cross section survey data highlight possibl negat impact potenti tobacco retail chang accord nation alcohol beverag control associ twelv state unit state us govern retail monopoli spiritsliquor sale new feder minimum legal sale age tobacco rais minimum legal sale age alcohol examin possibl unintend consequ hypothet polici chang restrict retail tobacco sale state run spiritsliquor store alcohol control state propos tobacco endgam strategi

D000437

T048

36,320,045

outcom right side left side colon diverticul follow non oper manag systemat review meta analysi suffici overview outcom right side left side colon diverticul cd follow non oper manag systemat review conduct evalu recurrencetreat failur right side left side cd

D004239

T047

36,320,044

work memori account emdr efficaci ptsd although eye movement desensit reprocess emdr shown effect treatment ptsd year remain controversi due lack understand mechan action examin whether work memori wm hypothesi competit limit wm resourc induc dual task attenu vivid emot traumat memori would provid explan benefici effect induc bilater stimul

D057169;D013313

T061;T048

36,320,043

pd fusion express dna vaccin elicit enhanc adapt immun respons hiv key role tlr sinc discoveri dna vaccin great interest abil elicit humor cellular immun respons show relat advantag regard produc stabil storag howev appli human subject inadequ immunogen remain greatest challeng practic use dna vaccin studi generat dna vaccin pd p encod fusion protein compris hiv gag p antigen extracellular domain murin pd novel endogen toll like receptor tlr agonist use mous model found pd p dna vaccin elicit higher antibodi respons increas number ifn produc cd cd cell moreov mice pd p dna vaccin protect subcutan challeng murin mesothelioma cell express hiv p antigen import pd mediat enhanc immun respons observ tlr knockout mice collect data demonstr immunogen efficaci dna vaccin could improv fusion extracellular domain pd target immunogen dendrit cell

D015497;D019444;D016915;D015658

T129;T121;T005;T114;T047

36,320,041

target hypoxia solid haematolog malign tumour hypoxia known extens research phenomenon occur solid haematolog malign cancer cell prolifer demand oxygen outstrip suppli reduc tumour oxygen solid tumour contribut disorgan blood vessel develop tumour hypoxia associ resist treatment aggress diseas behaviour increas likelihood metastat progress measur use invas non invas method vari degre accuraci presenc hypoxia stimul complex cellular network downstream factor includ hypoxia induc factor hif c x c motif chemokin cxcr hypoxia induc glycolyt enzym hexokinas hk amongst mani other work affect differ mechan includ influenc angiogenesi treatment resist immun surveil abil metastas contribut aggress diseas pattern tumour hypoxia correl poorer outcom wors prognosi patient correl hypox microenviron poor prognosi led interest tri therapeut target phenomenon various method use target hypox microenviron hypoxia activ prodrug hap drug activ within hypox environ agent subject investig sever clinic trial drug target downstream factor hypox environ includ hif inhibitor mammalian target rapamycin mtor inhibitor vascular endotheli growth factor anti vegf therapi also develop use combin clinic trial despit promis pre clinic data clinic trial hypoxia target strategi proven challeng understand effect hypoxia relat molecular mechan human rather anim model requir guid novel therapeut strategi futur trial design review discuss current avail method hypoxia target assess may consid plan futur clinic trial also outlin key trial date solid haemato oncolog treatment sphere discuss limit may impact clinic success date

D009369;D019337

T191

36,320,040

gata express clear cell adenocarcinoma lower urinari tract potenti diagnost pitfal clear cell adenocarcinoma lower urinari tract ccaclut rare primari malign neoplasm heterogen morpholog pauciti data literatur regard immunohistochem profil

D002295;D018262;D001749

T191

36,320,039

mendelian random analysi factor relat ovul reproduct function endometri cancer risk observ epidemiolog studi suggest link sever factor relat ovul reproduct function endometri cancer ec risk howev clear whether relationship causal whether risk factor act independ aim studi investig putat causal relationship number live birth age last live birth year ovul ec risk method conduct seri observ analys investig various risk factor ec risk uk biobank ukbb addit multivari analysi perform elucid relationship number live birth age last live birth year ovul relat factor age natur menopaus age menarch bodi mass index bmi second use mendelian random mr assess observ relationship causal genom wide signific singl nucleotid polymorph snps extract previous studi woman number live birth age menopaus menarch bmi conduct genom wide associ analysi use ukbb identifi snps associ year ovul year use contracept pill age last live birth

D057182;D016889

T062;T191

36,320,038

human intracrani pulsatil cardiac cycl comput model framework today avail medic imag comput resourc set scene high fidel comput model brain biomechan brain environ featur dynam complex interplay tissu blood cerebrospin fluid csf interstiti fluid isf design comput platform model simul intracrani dynam assess model valid term clinic relev indic brain pulsatil focus dynam interact tissu motion isfcsf flow treat pulsatil cerebr blood flow prescrib input model

D002552;D013346

T030

36,320,037

symptom prolong grief disord posttraumat stress disord depress relat griev icu famili first two year bereav bereav icu famili surrog risk comorbid prolong grief disord pgd posttraumat stress disord ptsd depress knowledg tempor relationship pgd ptsd depress limit lack relev studi divers inappropri assess time frame given durat criterion pgd aim determin tempor reciproc relationship pgd ptsd depress symptom among icu deced famili surrog first bereav year assess time frame reflect pgd durat criterion

D013313;D001601

T041;T048

36,320,036

steril insect techniqu pilot trial captiva island defin mosquito popul paramet steril male releas use mark releas recaptur steril insect techniqu sit involv area wide inund releas steril insect suppress reproduct target speci proven effect pest control method techniqu demand continu releas steril insect quantiti ensur high steril male wild male ratio suppress wild popul succeed generat

D000330;D007248

T033;T184;T047;T204

36,320,035

develop accredit standard midwiferi clinic educ iran accredit one import method qualiti assur improv medic educ iran specif midwiferi educ accredit standard studi design develop accredit standard midwiferi clinic educ iran

D008880;D004508

T065;T091;T097

36,320,034

late relaps ulcer coliti present tracheobronch case report lung involv inflammatori bowel diseas usual follow coliti howev time lung involv onset vari depend case pulmonari lesion usual parallel exacerb coliti

D003093;D014136;D001991

T047

36,320,033

pilot studi chcf genotyp pig challeng model enterotoxigen escherichia coli fabac associ post wean diarrhea host genotyp import enterotoxigen e coli etec suscept conduct two trial evalu effect chcf genotyp incid etec diarrhea trial n pig pig inocul cfu cfu dose etec fac strain trial n pig pig inocul etec fab fac across trial inocul pig develop etec diarrhea chcf heterozyg suscept inocul chcf homozyg resist pig develop etec diarrhea suscept toward etec facab infect might correspond chcf genotyp

D054307;D013553;D004927

T047;T007

36,320,031

compar analysi impact onlin blend face face learn medic student clinic compet affect cognit psychomotor domain coronavirus diseas covid pandem south africa compel medic school switch pure onlin curriculum innov chang transform standard clinic skill curriculum increas learn transfer bridg theori practic gap efficaci intervent remain unknown studi aim measur medic student clinic compet affect cognit psychomotor domain assess clinic skill knowledg retent transfer onlin platform compar face face blend learn

D013337;D000086382

T047;T067;T097

36,320,029

evalu hous staff candid program fit cohort base control studi medic school academ achiev necessarili predict hous staff job perform studi explor select mechan improv hous staff program fit enhanc accredit council graduat medic educ mileston perform rate

D007396

T065;T097

36,320,028

lp oxid phospholipid oxid specif epitop increas subject keloid format keloid format follow trauma surgeri common among dark pigment individu sinc lipoprotein lp postul putat role wound heal also mediat atherosclerot cardiovascular diseas assess whether lp associ oxid phospholipid oxid specif biomark associ keloid format

D000936;D010743

T129;T123;T116;T109

36,320,027

matern factor pregnanc influenc matern fetal childhood outcom enhanc pregnanc health known improv mother offspr life long well matern environ encompass genet factor impact social determin nutritionalmetabol milieu infect inflamm immedi consequ utero develop fetus long term program childhood adulthood moreov advers pregnanc outcom preterm birth preeclampsia often attribut matern environment factor list associ poor matern cardiometabol health pregnanc bmc medicin articl collect explor broad spectrum matern characterist across pregnanc postnat phenotyp anticip substanti cross fertil new understand share mechan around divers outcom advanc abil leverag omic across differ platform genom transcriptom proteom metabolom microbiom lipidom larg high dimension popul databas uniqu cohort generat excit new insight first articl collect highlight role placent biomark preterm birth metabol influenc fetal childhood growth impact common pre exist matern disord obes smoke pregnanc outcom child health collect grow look forward see connect emerg across matern fetal childhood outcom foster new insight prevent strategi women

D047928;D011225

T046

36,320,025

effect complementari music intervent patient qualiti life septoplasti rhinoplasti qualiti life qol assess emerg import evalu tool therapeut treatment posit impact complementari music intervent qol demonstr literatur particular chronic malign diseas howev benefit periop period head neck patient investig thus far

D012225;D009146;D009147;D015508

T061;T047;T170;T033

36,320,023

incid clinic characterist risk factor outcom patient mix candidabacteri bloodstream infect retrospect studi mix candidabacteri bloodstream infect mix cb bsis worthi particular attent recent analyz incid co pathogen clinic characterist risk factor outcom mix cb bsis compar monomicrobi candidemia mono candidemia adult patient china

D002177;D058387;D001424;D060085

T047

36,320,021

sleep disturb associ mild cognit impair communiti popul base cross section studi sleep conduc elimin brain metabolit recoveri brain function howev relationship sleep disturb mild cognit impair fulli determin

D060825;D012893

T047;T048

36,320,019

muscl strength associ fractur risk obtain fractur risk assess tool frax women breast cancer women breast cancer risk develop sarcopenia occurr fractur initi period screen condit prevent risk disabl poor qualiti life death present studi investig associ sarcopenia phenotyp fractur risk assess fractur risk assess tool frax women breast cancer

D055948;D006620;D009369

T047;T191;T037

36,320,018

evalu diurnal postur intracrani pressur employ telemetr monitor idiopath intracrani hypertens intracrani pressur icp thought vari diurnal studi evalu diurnal icp measur quantifi chang icp occur chang bodi postur activ idiopath intracrani hypertens iih

D007427;D011559

T047;T042

36,320,017

meat consumpt risk general central obes shahedieh studi studi aim investig relat total meat intak subtyp includ red process meat white meat poultri fish organ meat risk generalcentr obes

D056128;D009765

T033;T184;T047

36,320,016

influenc artifici saliva clean forc interdent rubber pick vitro comparison familiar aid interdent clean dental floss interdent brush idb often associ difficult handl increas potenti trauma interdent pick irp metal core silicon flap instead nylon brush offer altern howev vitro studi found lower clean effect combin higher forc clean compar convent idb aim vitro studi measur experiment clean forc ecf use irp versus without artifici saliva gum hydral sunstar suiss sa etoy switzerland

D003742;D003773

T047;T074;T073

36,320,015

counti level associ food retail avail violent crime rate violent crime ie homicid arm robberi aggrav assault rape continu major public health concern america sever studi link avail densiti specif featur retail food environ conveni store liquor store violent crime rate due crimin activ often occur near retail nevertheless continu limit understand featur eg groceri store supercent restaur etc associ violent crime occurr studi aim fill gap knowledg examin us counti level associ food retail avail violent crime rate

D012111;D003132

T078;T082;T083;T033;T056;T096;T097;T081;T057

36,320,014

small nodul mm diamet multipl primari lung cancer preval manag synchron multipl primari lung cancer associ small non domin nodul common encount howev incid follow treatment small non domin tumor littl studi explor preval manag small non domin tumor factor associ interv growth

D055613;D008175;D009378;D003074

T033;T047;T191

36,320,013

occup industri specif cancer mortal among japanes women number women japan continu work childbirth rise past year japan cancer mortal rate increas cancer death among japanes women age caus lung gastric pancreat colorect cancer studi aim examin differ mortal risk key cancer among women explor effect econom crisi mid separ occup industri categori

D009790;D009369

T090;T191;T057

36,320,012

investig causal relationship al autoimmun disord mendelian random studi epidemiolog studi report associ amyotroph later sclerosi al differ autoimmun disord studi aim explor causal relationship autoimmun disord al use mendelian random mr

D000690;D001327

T047

36,320,011

gender relat factor associ delay diagnosi tuberculosi eastern europ central asia tuberculosi tb prevent treatabl diseas year affect million peopl take million live recogn symptom obtain correct diagnosi vital step toward treatment cure time person tb get diagnos may influenc biolog differ sex factor link person gender context prevail gender norm accord hypothesi gender relat factor contribut delay diagnosi tb investig four countri georgia kazakhstan republ moldova tajikistan eastern europ central asia eeca region high burden drug resist tb scarciti gender relat tb inform vari gender equal retrospect inform collect direct peopl histori tb depth interview focus group discuss find differ gender way particip recogn tb symptom three countri women de priorit seek diagnosi lack access financ household relat oblig four countri men tradit carri weight econom support famili tend postpon tb diagnosi two countri women experienc stigma often men deterr factor seek healthcar role gender obtain correct diagnosi came forth among respond georgia extent kazakhstan conclud barrier health care seek tb diagnosi affect differ women men gender divers person eeca region

D014376;D018088

T047

36,320,010

predict violenc male schizophrenia use smri base machin learn algorithm violent behavior patient schizophrenia scz major social problem earli identif scz patient violenc facilit implement target intervent

D012559

T048

36,320,008

high tumor hexokinas express promot pro tumorigen immun microenviron modul cdregulatori cell infiltr relationship cancer cell glycolysi landscap tumor immun microenviron human cancer investig

D002289;D008175;D000077192;D002294

T191

36,320,007

preval patholog equin parvovirus hepat racehors new york racetrack theiler diseas aka equin serum hepat devast high fatal diseas hors equin parvovirus hepat eqpv h identifi like caus diseas incid theiler diseas low preval eqpv h dna hors high region suggest subclin persist infect common

D006734;D006524;D017992;D019219;D006505

T047;T005

36,320,006

comprehens analysi express prognosi iq motif contain gtpase activ protein hepatocellular carcinoma iq motif contain gtpase activ protein iqgap group scaffold protein identifi involv tumor initi progress divers type cancer clinic studi experiment evid suggest iqgap play essenti role hepatocellular carcinoma hcc progress alter express close relat patient prognosi howev differ express pattern prognost valu three iqgap isoform hcc yet analyz simultan

D006528;D008113

T191

36,320,005

qualit inquiri percept hiv pre exposur prophylaxi among peopl inject drug live hepat c seattl wa usa incid hiv among person inject drug pwid usa increas sinc signal need identifi effect way engag pwid hiv prevent servic name pre exposur prophylaxi prep yet uptak prep popul minim compar popul risk hiv acquisit work sought explor knowledg attitud perspect prep accept among pwid

D065129;D015819;D055030;D019380;D015658;D006526

T061;T121;T098;T033;T047;T101;T048

36,320,004

preval factor associ depress among older adult case low incom countri ethiopia systemat review meta analysi depress among common mental health problem late life import public health problem studi middl high incom countri shown depress common among older peopl adolesc mani older peopl depress overlook fewer effort made mitig suffer despit depress major public health problem among older adult overal magnitud main predictor determin develop appropri measur henc object studi therefor estim overal preval depress identifi predictor among older adult ethiopia

D003863;D011203

T184;T098;T102;T064;T048

36,320,003

psoriasi cardiovascular diseas risk european east asian popul evid meta analysi mendelian random analysi psoriasi link cardiovascular diseas cvd includ coronari arteri diseas cad myocardi infarct mi heart failur hf howev avail studi regard relationship shown inconsist result therefor report perform comprehens review literatur assess effect psoriasi risk cvds

D002318;D003324;D009203;D011565

T047

36,320,002

conserv surgeri microwav ablat recurr bone tumor extrem singl center studi surgic treatment recurr bone tumor extrem still present challeng studi design evalu clinic valu microwav ablat treatment recurr bone tumor

D008872;D001859

T070;T191;T057

36,320,001

impact covid pandem anxieti depress among physic therapist saudi arabia cross section studi physic therapist may becom infect treat patient sinc direct contact within two meter radius addit physic therapist may feel suscept covid infect appli rehabilit practic often involv direct contact patient physic therapist survey level anxieti depress due coronavirus diseas pandem covid

D000086382;D059825

T047;T097;T067

36,320,000

associ alcohol use memori declin middl age older chines longitudin cohort studi previous studi associ alcohol use memori declin show inconclus result examin associ use longitudin data guangzhou biobank cohort studi gbcs explor whether associ vari sex age group

D000428;D008569

T055;T184;T048

36,319,999

comparison effect anchor needl coil local multipl nodul lung recent new type pulmonari nodul posit needl adopt clinic aim evalu efficaci safeti new type local needl compar coil simultan local multipl pulmonari nodul guid comput tomographi ct prior video assist thoracoscop surgeri vat

D055613;D003074;D008175

T033;T047;T191

36,319,998

nk cell solid tumor therapeut potenti persist obstacl natur killer nk cell innat lymphocyt endow potent cytotox activ recent attract attent potenti anticanc therapeut nk cell mediat encourag respons patient leukemia therapeut effect nk cell infus patient solid tumor limit preclin clinic data suggest efficaci nk cell infus solid malign hamper sever factor includ inadequ tumor infiltr persistenceactiv tumor microenviron tme number metabol featur tme includ hypoxia well elev level adenosin reactiv oxygen speci prostaglandin negat affect nk cell activ moreov cancer associ fibroblast tumor associ macrophag myeloid deriv suppressor cell regulatori cell activ suppress nk cell depend anticanc immun review metabol cellular barrier inhibit nk cell solid neoplasm discuss potenti strategi circumv obstacl toward superior therapeut activ

D009369;D000072737

T191;T025

36,319,997

user make judgement qualiti onlin health inform cross section survey studi peopl increas use internet seek health inform howev overal qualiti onlin health inform remain low situat exacerb unpreced infodem negat consequ patient therefor import understand user make judgement health inform appli differ judgement criteria

D057220;D017216

T058;T041

36,319,996

magnitud diabet peripher neuropathi saudi arabia systemat review meta analysi diabet peripher neuropathi dpn due potenti caus morbid disabl foot ulcer amput increas becom sourc concern saudi arabia worldwid howev wide variabl exist preval dpn report previous studi saudi arabia limit util exist data nation public health polici therefor aim studi systemat evalu magnitud dpn patient live dm saudi arabia order inform policymak implement appropri prevent treatment strategi dpn

D003929;D003920

T047

36,319,995

spatiotempor analysi sever fever thrombocytopenia syndrom shandong provinc china due recent emerg sever fever thrombocytopenia syndrom sfts becom one major public health problem shandong provinc china number report sfts case general area report sfts case continu increas recent year howev spatiotempor pattern cluster sfts shandong provinc investig yet

D000085142

T047

36,319,994

heal effect monom dimer resveratrol mous periodont model antioxid anti inflammatori effect resveratrol report previous particular monomer tran resveratrol demonstr produc posit effect various patholog process report previous resveratrol dimer rich melinjo extract among other caus bone heal decreas local oxid damag activ antioxid nuclear factor erythroid relat factor nrf pathway mous model experiment induc periodont ep studi aim compar bone heal effect resveratrol monom resveratrol dimer gnetin c found melinjo seed extract model ep investig involv nrf effect either form resveratrol

D010518;D016301

T047

36,319,993

general paediatr dentist knowledg attitud practis regard use silver diammin fluorid manag dental cari nation survey netherland silver diammin fluorid sdf topic medic use arrest cavit carious lesion non invas primari aim investig analys relationship knowledg attitud practis includ barrier facilit sdf use manag dental cari general dental practition gdps paediatr dentist pds netherland secondari aim explor differ group

D003815;D003731

T033;T047;T097

36,319,992

warburg effect colorect cancer emerg role tumor microenviron therapeut implic colorect cancer crc third common cancer second lead caus cancer relat death worldwid countless crc patient undergo diseas progress hallmark cancer warburg effect promot cancer metastasi remodel tumor microenviron includ promot angiogenesi immun suppress cancer associ fibroblast format drug resist target warburg metabol would promis method treatment crc review summar inform role warburg effect tumor microenviron elucid mechan govern warburg effect crc identifi novel target therapi

D015179;D000072645

T191;T025

36,319,991

magnitud common mental disord associ factor among patient epilepsi amhara region state northwest ethiopia common mental disord sever frequent co morbid psychiatr ill epilepsi differ studi find across world show patient epilepsi higher burden mental disord general popul howev issu patient epilepsi consist undiagnos

D001523;D004827

T033;T047;T048

36,319,990

effect local tailor intervent uptak preconcept care netherland step wedg cluster random trial apropo ii studi preconcept period provid window opportun intervent aim reduc unhealthi lifestyl behaviour negat effect pregnanc outcom studi aim assess effect local tailor preconcept care pcc intervent hybrid ii effect implement design

D016742;D008019

T058;T054;T047

36,319,988

dietari intak yogurt chees children age year sleep durat age year japan environ children studi previous report year old infant born mother regular consum ferment food pregnanc lower risk sleep depriv howev known posit effect enhanc infant eat ferment food long term effect consumpt studi examin associ frequenc ferment food intak child wean period sleep depriv age year

D015014;D002611

T168

36,319,987

paradox breast cancer incid mortal two corner europ breast cancer incid rise global mortal rate show geograph heterogen pattern earli detect treatment proven profound impact breast cancer prognosi aim studi compar breast cancer incid mortal surviv rate two contrast corner europ sweden crete better understand cancer determin focus diseas burden sociocultur factor

D001943

T191

36,319,986

prognost valu high sensit cardiac troponin earli coronari arteri bypass graft surgeri diagnosi periprocedur myocardi infarct pmi coronari arteri bypass graft cabg base biochem marker along clinic instrument find howev clear cutoff valu high sensit cardiac troponin hs ctn identifi pmi hypothes isol hs ctn concentr first h follow cabg could predict cardiac advers event hospit death pmi andor left ventricular eject fraction lvef decreas

D019210;D009203

T123;T047;T116

36,319,985

prognost valu combin mtv adc deriv baselin fdg petmri aggress non hodgkin lymphoma aim prospect studi investig prognost valu metabol tumor volum mtv appar diffus coeffici adc baselin fdg petmri compar establish clinic risk factor term progress free surviv pfs year cohort diffus larg b cell lymphoma dlbcl high grade b cell lymphoma hgbcl

D008228;D016403

T191

36,319,982

employe healthi eat physic activ role colleagu encourag behaviour exercis eat healthi individu choic influenc famili member friend neighbour littl known howev colleagu anoth import interperson influenc mani peopl spend mani hour work surround most colleagu could therefor signific shape employe un healthi choic studi extent colleagu may play part one anoth eat exercis behaviour focus two pathway colleagu encourag healthi lifestyl act role model whose behaviour observ copi

D000072001;D016272

T061;T078;T091;T055;T033

36,319,981

implement fidel brazilian drug use prevent program effect among adolesc mix method studi base us dare kir version keepin real program drug violenc resist educ program proerd wide implement brazilian prevent program origin translat dare kir version keepin real program previous result suggest ineffici prevent drug use among brazilian adolesc sinc kir fidel impact program outcom mix method studi evalu proerd implement fidel effect prevent drug use among adolesc

D012572;D019966

T033;T058;T048

36,319,980

unlik oxygen supplement copd patient chronic respiratori failur reduc cardiac troponin level cardiac troponin ctnt biomark myocardi injuri frequent elev copd patient potenti hypoxemia non randomis observ studi investig whether long term oxygen treatment ltot reduc ctnt level

D029424;D000142

T047

36,319,979

view hong kong parent secondari use dri blood spot newborn screen program residu dri blood spot rdbs newborn screen programm repres valuabl resourc medic research basic scienc clinic public health hong kong legisl biobank parent view retent use residu newborn blood sampl could cultur specif import consid biobank rdbs

D015997;D018070

T061;T093

36,319,978

indoleamin dioxygenas immunohistochem express medullari thyroid carcinoma implic prognosi immunomodulatori effect linkag ido express cancer progress still unclear particular medullari thyroid carcinoma mtc purpos unveil potenti correl ido status clinic patholog paramet patient prognosi possibl immunomodulatori function mtc

D013964;D018278

T191