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36,319,129
applic anterolater thigh flap preform tongu patient total glossectomi object investig efficaci anterolater thigh flap preform tongu patient total glossectomi method total patient tongu cancer underw total glossectomi neck lymph node dissect anterolater thigh flap transfer collect januari april depart oral maxillofaci surgeri second xiangya hospit patient male age rang year patient divid experiment case control case group base whether tongu reconstruct clinic paramet two group analyz independ sampl test fisher exact probabl method result success rate free flap patient patient cervic hematoma patient wound infect postop differ speech vs p swallow p function two group month surgeri howev speech vs p swallow p function experiment group signific better control group case lost follow patient extub oper averag time day experiment group day control group overal surviv rate experiment group control group conclus use anterolater thigh flap preform tongu improv speech swallow function patient total glossectomi offer novel method tongu construct
D014062;D058752
T191;T024
36,319,128
applic later upper arm free flap repair postop defect oral cancer object explor clinic applic efficaci later upper arm free flap luaff one stage repair soft tissu defect oral cancer surgeri method articl retrospect analysi clinic data patient receiv treatment one stage repair soft tissu defect luaff oral cancer surgeri hunan cancer hospit june june among case male femal patient age year old clinic data patient review outcom evalu spss softwar use statist analysi result luaff patient flap area rang cm cm cm cm mean pedicl length cm mean arteri diamet mm rang mm mean diamet largest vein mm median number perfor rang donor site close primarili two case arteri anastomosi thrombosi flap success save urgent anastomosi vessel overal flap surviv rate flap necros oper three case patient receiv tracheotomi averag hospit stay time patient oper day follow time month elbow wrist movement oper side normal upper limb muscl strength affect conclus luaff suitabl choic repair small moder tissu defect oral cancer surgeri consist perfor flap simpl harvest method conceal donor site scar high surviv rate
D058752;D009062
T191;T024
36,319,127
applic pedicl nasosept flap endoscop nasopharyngectomi recurr nasopharyng carcinoma analysi case object explor therapeut effect contribut factor pedicl nasosept flap endoscop nasopharyngectomi recurr nasopharyng carcinoma method thirti nine patient recurr nasopharyng carcinoma admit eye ear nose throat hospit fudan univers juli juli review male femal age year old patient underw endoscop nasopharyngectomi follow reconstruct pedicl nasosept flap method preoper assess mucos flap prepar nasopharyng reconstruct summar factor affect surviv pedicl nasosept flap discuss rate group compar fisher exact test result ipsilater mucos flap use case contralater mucos flap case oper case complet epitheli case flap necrosi univari analysi suggest number radiotherapi cours import factor affect surviv flap ci p howev gender age type transnas endoscop nasopharyngectomi osteonecrosi side flap intern carotid arteri resect influenc flap surviv p patient follow month among patient local recurr oper patient surviv system metastas patient die conclus pedicl nasosept flap good materi reconstruct endoscop nasopharyngectomi less effect patient multipl cours radiotherapi
D059747;D000077274;D009303;D010611;D009364
T061;T191
36,319,126
mechan pepsin promot lingual tonsil hypertrophi stimul macrophag object investig possibl pathophysiolog mechan laryngopharyng reflux lpr develop lingual tonsil hypertrophi lth method lingual tonsil tissu collect patient male femal age year underw surgeri laryngopharyng diseas depart otolaryngolog head neck surgeri southern hospit southern medic univers octob decemb lingual tonsil grade ltg reflux symptom index rsi reflux find score rfs assess express pepsin lth detect immunohistochemistri coexpress pepsin macrophag detect immunohistofluoresc vitro cytolog experi pathway assay perform macrophag stimul pepsin pathway alter macrophag pepsin posit high grade lth detect doubl fluoresc immunohistochemistri data analyz spss softwar result clinic signific lprd patient ltg pepsin posit rate pepsin posit rate ltg ltg signific posit correl rfsrsi posit rate p r p pepsin tissu stain intens h p r p respect pepsin macrophag clear coloc high grade lth vitro pepsin promot macrophag prolifer p product il il p pepsin signific regul pjnk mapk pathway macrophag p pepsin regul express il il macrophag activ p mapk pathway p regul express il activ jnk pathway p pjnk mapk pathway high express macrophag pepsin posit lth p conclus lpr import pathogen factor lth macrophag may mediat pepsin induc inflamm pathogenesi lth
D014066;D057045
T023;T046;T047
36,319,125
analysi person characterist patient laryngopharyng reflux diseas object explor basic psycholog person characterist patient laryngopharyng reflux diseas lprd method minnesota multiphas person inventori mmpi use investig psycholog person characterist patient lprd studi group healthi subject control group treat otolaryngolog clinic wuhan central hospit januari decemb male studi group age year femal age year male control group age year femal age year spss softwar use statist analysi result score hs hypochondriac scale depress scale hy hysteria scale hypomania scale mas explicit anxieti scale lprd patient signific higher healthi control p correl analysi show rsi score posit correl score hs hypochondriac scale hy hysteria scale hypomania scale mas explicit anxieti scale r p rfs score posit correl score hs hypochondriac scale hy hysteria scale mas explicit anxieti scale r p conclus compar healthi peopl lprd patient special person psycholog characterist main manifest excess attent exagger ill depress sensit somat psycholog problem irrit mania sever subject symptom rsi object sign rfs lprd patient relat psycholog person characterist
D057045
T047;T046
36,319,124
role continu h oropharyng ph monitor diagnosi laryngopharyng reflux diseas object investig daili variat lpr signific hour oropharyng ph monitor diagnosi lprd method subject suspect lprd treat depart june june includ patient hospit complet continu hour oropharyng dx ph monitor consist ryan index w index correl various reflux paramet first second hour compar spss use statist analysi result subject success complet hour oropharyng dx ph monitor ryan index posit case first hour case second hour case first second case either hour kappa p case inconsist result first hour second hour signific differ posit rate first second p number posit case hour monitor increas compar hour monitoringfor w index case posit first hourf case posit second hour case posit first second case posit either hour kappa p correl comparison show correl various reflux paramet upright posit lower supin posit conclus laryng reflux daili variabl extend monitor time dx ph hour help reduc miss diagnosi caus daili variabl use w index reduc influenc daili variabl diagnost result lprd
D057045;D007830
T047;T046;T023;T030
36,319,123
evalu reliabl valid chines version new symptom score laryngopharyng reflux diseas object produc chines version new reflux symptom score rss laryngopharyng reflux diseas lprd evalu reliabl valid clinic valu method retrospect studi contain healthi volunt possibl lprd patient rsi rfs oropharyng ph monitor dx ph monitor rss patient perform rss perform week confirm lprd patient treat proton pump inhibitor week rss perform treatment reliabl valid rss evalu result cronbach coeffici rss indic good intern reliabl new score result test retest found p valu less support good extern reliabl compar rss laryngopharyng reflux test result diagnost coincid rate posit predict valu show good criterion valid week treatment ppi rss decreas signific pretreat posttreat p indic good reactiv rss score qualiti life impact qol possibl lprd patient obvious higher healthi volunt p patient volunt believ rss good way evalu symptom conclus new score rss good intern extern reliabl criterion valid reactiv rss one import refer index evalu lprd
D057045
T047;T046
36,319,122
effect gastroesophag reflux diseas clinic characterist patient laryngopharyng reflux diseas object investig effect gastroesophag reflux diseas gerd clinic characterist patient laryngopharyng reflux diseas lprd method data patient symptom lprd admit depart pharyngolog laryngolog phonosurgeri sixth medic center pla general hospit novemb octob retrospect analyzedther male femal age year old includ patient underw simultan hour hypopharyng esophag multichannel intralumin imped ph monitor h hemii ph salivari pepsin test multipl time reflux symptom index rsi reflux find score rfs one laryngopharyng reflux event h hemii ph monitor result use diagnost criterion lprd durat lower esophag ph use diagnost criteria gerd among patient posit lprd gerd classifi l g group patient posit lprd negat gerd classifi il group patient negat lprd posit gerd classifi ig group patient negat lprd gerd classifi n group differ clinic characterist reflux salivari pepsin assay group statist analyz spss softwar appli statist analysi result accord h hemii ph result patient diagnos lprd gerd includ il group l g group ig group n group base salivari pepsin test total patient posit result l g group signific higher rate posit total salivari pepsin test posit morn test il group ig group n group chi squar valu p patient l g group signific higher rsi score il group ig group n group h p conclus combin gerd lprd patient obvious clinic symptom higher posit rate pepsin test saliva
D057045
T047;T046
36,319,121
cut valu eosinophil chronic rhinosinus eosinophil chronic rhinosinusitisecrsecrsecrsecr
D012852
T047
36,319,120
advanc vigor promot studi laryngopharyng reflux diseas
D057045
T047;T046
36,319,116
oligometastat prostat cancer current status futur challeng accord spectrum theori metastat diseas oligometastat clinic state propos intermediari step along natur histori cancer typic metastat lesion identifi imag may amen metastasi direct therapi effect therapi oligometastat diseas anticip impact cancer evolut delay progress improv patient outcom minim accept cost toxic increas recognit oligometastat diseas prostat cancer advent new generat imag agent notabl recent approv pet radiotrac base target prostat specif membran antigen earli clinic trial metastasi direct therapi oligometastas provid evid delay employ systemat therapi improv outcom select patient despit encourag result much need investig learn under biolog oligometastat state along evolutionari clinic cours prostat cancer identif relev imag nonimag predict prognost biomark develop treatment strategi optim short term long term patient outcom provid review current status linger challeng rapid evolv clinic space prostat cancer
D011471
T191
36,319,112
snmmi highlight lectur neurosci newslin editor highlight lectur present close session snmmi annual meet origin present year henri n wagner jr md begin duti summar select signific present meet divid annual among distinguish nuclear molecular medicin subject matter expert year newslin publish lectur select imag highlight lectur deliv june snmmi annual meet vancouv canada issu featur lectur juli price phd professor radiolog harvard medic school director pet pharmacokinet model athinoula martino center biomed imag massachusett general hospit boston spoke neurosci highlight meet note follow present summari numer bracket repres abstract number publish journal nuclear medicin suppl
D009488;D009683
T091
36,319,107
research progress role foxo famili cancer forkhead box class protein foxo famili consist high conserv transcript factor includ foxo foxo foxo foxo member foxo famili ubiquit express involv regul mani biolog activ tumor cell prolifer apoptosi migrat oxid stress activ foxo main regul post translat modif inactiv main mediat activ upstream modifi enzym provid possibl use drug recov activ worth note foxo inhibit also promot occurr develop human tumor due complex effect foxo review summar structur activ regul foxo discuss tumor inhibit effect limit cell prolifer induc apoptosi well tumor promot effect maintain cell homeostasi promot metastasi induc drug resist provid new idea patholog research relat diseas open new way promot broader prevent treatment strategi
D009369
T191
36,319,106
contribut impair adult hippocamp neurogenesi occurr develop diabet encephalopathi diabet encephalopathi de one common complic diabet mellitus dm persist hyperglycemia dm patient may induc numer pathophysiolog chang chronic inflamm increas permeabl blood brain barrier impair neurogenesi brain atrophi eventu impair cognit function dentat gyrus dg hippocampus crucial region learn memori well adult neurogenesi mammal recent studi shown adult hippocamp neurogenesi ahn exist throughout life decreas age wherea ahn signific impair de therefor numer effort current focus explor mechan under cognit impair induc ahn dysfunct de summar studi contribut ahn disord occurr develop de relat mechan order shed light prevent treatment de
D060825;D001927;D003920
T047;T048
36,319,105
regul toll like receptor downstream factor butyr butyr normal produc probiot gut provid energi cell also chang phosphoryl acetyl methyl level mani protein cell result affect express mani gene transmiss cell signal g protein coupl receptor butyr promot secret intestin mucus format epitheli barrier attenu impact pathogen bacteria metabolit human bodi toll like receptor tlrs group pattern recognit receptor activ caus transloc nuclear factor b nf b cytoplasm nucleus eventu lead express secret various pro inflammatori factor chemokin express tlrs also involv pathogenesi inflammatori diseas tumor purpos review summar effect butyr tlrs downstream signal pathway summar product butyr express tlrs influenc interact bodi condit inflamm tumor also discuss potenti role butyr bacteri metabolit treatment human diseas
D002087;D051193
T192;T116;T109
36,319,104
research progress mechan exercis improv non alcohol fatti liver diseas regul endoplasm reticulum stress non alcohol fatti liver diseas nafld one main diseas metabol syndrom increas popular nafld world prevent therapi nafld face great challeng recent year scholar home abroad carri larg number studi nafld pathogenesi still unclear endoplasm reticulum stress er caus accumul unfold misfold protein respons er cell help restor normal endoplasm reticulum function initi protect mechan known unfold protein respons upr abnorm accumul lipid hepatocyt aggrav inflammatori respons increas apoptosi hepatocyt insulin resist ir main pathogen factor characterist nafld close relat hepat er larg number studi shown exercis low cost treatment prevent improv nafld effect mechan relat exercis regul level er paper review research progress mechan exercis improv nafld point view er mechan exercis improv nafld relat regul hepatocyt lipid metabol allevi inflammatori reaction reduct hepatocyt apoptosi improv ir regul er
D065626;D007333
T047;T046
36,319,103
lipid metabol intermedi regul skelet muscl insulin sensit skelet muscl largest organ human bodi complet glucos intak stimul insulin close relat occurr develop insulin resist ir skelet muscl one main place lipid metabol lipid metabolit particip skelet muscl metabol signal molecul fatti acid regul skelet muscl insulin sensit insulin signal pathway inflammatori respons mitochondri function satur fatti acid sfas induc insulin resist impair insulin signal transduct induc mitochondri dysfunct inflammatori respons unsatur fatti acid revers advers effect sfas amelior ir enhanc insulin signal transduct anti inflammatori effect addit disord lipid metabol skelet muscl caus accumul harm metabol intermedi diacylglycerol ceramid long chain acyl coenzym induc ir direct indirect damag insulin signal pathway articl review research progress lipid metabol intermedi regul insulin sensit skelet muscl help better understand pathogenesi diabet
D007333
T046
36,319,102
exercis precondit reduc exercis induc risk cardiovascular event obes popul obes independ risk factor cardiovascular diseas epidemiolog studi shown obes induc product inflammatori factor chang cardiac hemodynam remodel function lead myocardi damag heart diseas posit effect exercis cardiovascular system wide confirm acut cardiovascular stress caus exercis ignor compar general popul obes peopl prone arrhythmia higher risk cardiovascular event exercis due abnorm cardiac function myocardi patholog remodel low toler correspond stress studi shown intervent exercis precondit ep effect reduc risk ep increas myocardi oxygen consumpt short term exercis result relat absolut myocardi ischemia induc intrins myocardi protect effect reduc continu ischemia caus subsequ long term exercis articl review obes induc abnorm chang cardiac function structur possibl exercis induc risk cardiovascular event obes peopl role ep reduc exercis induc risk cardiovascular event summar progress ep model obes peopl ep prevent advers cardiovascular event obes peopl aim provid theoret basi applic ep obes peopl
D017202;D002318
T047
36,319,101
obes hypertriglyceridemia high risk diseas sever mortal covid patient covid pandem approach third year data shown obes hypertriglyceridemia high risk factor major complic acut respiratori distress syndrom thromboembol coagulopathi cytokin storm respons major diseas sever mortal review articl analyz public avail clinic report laboratori research result covid studi research clinician mani nation around world mani report cover covid patient differ ethnic group suggest obes high triglycerid high risk sever covid death also summar possibl under molecular mechan like connect sever covid obes hypertriglyceridemia public health perspect highlight import healthi diet lifestyl fight sar cov virus long period time
D000086382;D015228
T047;T067
36,319,100
inhibit wnt signal pathway contribut cardiac protect exercis train spontan hypertens rat object studi investig cardiac protect effect low moder intens exercis train role wnt signal pathway spontan hypertens rat shr shr wistar kyoto wki rat random divid group name hypertens control shr hypertens plus exercis train shr e normal blood pressur control wki normal blood pressur plus exercis train wki e shr e plus wnt agonist shr e wnt rat shr e wki e group underw low moder intens swim week rat shr e wnt group inject wnt agonist tail vein week end swim blood pressur rat measur everi week exercis train left ventricular wall thick eject function measur ultrasound cardiogram myocardi structur collagen fiber chang observ stain masson stain express level catenin dishevel dvl mrna protein left ventricular myocardium detect real time fluoresc quantit pcr western blot respect result show bodi weight decreas p blood pressur increas p heart weight ventricular wall thick increas p left ventricular eject function decreas p shr group compar wki group addit heart structur damag collagen fiber signific increas mrna protein express catenin dvl left ventricl signific regul shr group compar wki group p blood pressur decreas p heart weight ventricular wall thick diminish eject function increas p myocardi structur injuri signific improv collagen fiber signific reduc mrna protein express level catenin dvl left ventricl signific regul p shr e group import exercis induc antihypertens cardioprotect effect shr blunt wnt agonist result suggest low moder intens exercis train exert cardioprotect effect shr possibl inhibit wnt signal pathway
D051176;D010805
T123;T116;T038
36,319,099
circrna regul arsenic trioxid induc apoptosi vascular endotheli cell present studi aim investig effect circrna apoptosi vascular endotheli cell induc arsenic trioxid human umbil vein endotheli cell huvec treat moll h cellular viabil measur mtt assay express level circrna bcl bax mrna detect real time quantit pcr bcl bax protein ratio detect western blot whether circrna involv regul huvec investig transfect overexpress plasmid circrna sirna result show compar control group group show decreas cellular viabil reduc bcl bax mrna protein ratio signific lower express circrna overexpress circrna inhibit apoptosi huvec induc knockdown circrna sirna promot induc apoptosi huvec result suggest circrna involv vascular endotheli cell apoptosi induc
D000079962;D017209
T123;T116;T114;T043
36,319,098
bioinformat analysi microrna express profil peripher blood lymphocyt kazakh patient essenti hypertens xinjiang studi aim investig differenti express profil microrna mirna peripher blood lymphocyt patient essenti hypertens healthi individu xinjiang kazakh provid insight mechan involv pathogenesi hypertens ethnic group april may kazakh patient essenti hypertens inpati outpati depart cardiolog first affili hospit shihezi univers use hypertens group healthi kazakh patient use control group mirna express profil peripher blood lymphocyt kazakh hypertens patient match healthi individu compar differenti express mirna analyz cluster analysi gsea enrich analysi target gene predict target gene annot bioinformat analys addit qrt pcr use verifi differenti express mirna result show compar control group differenti express mirna identifi hypertens group mirna regul mirna regul total mirna relat hypertens screen gsea enrich analysi includ hsa mir p hsa mir p hsa mir p hsa mir p hsa mir p hsa mir b p hsa mir p hsa mir p hsa mir p hsa mir hsa mir qrt pcr test found express hsa mir p hsa mir p hsa mir p hsa mir b p hsa mir p hsa mir p hsa mir regul express hsa mir p hsa mir p hsa mir p hsa mir regul hypertens group compar control group express trend gene chip consist result verifi qrt pcr use onlin databas predict target gene mirna relat hypertens found total target gene might regul mirna go function enrich show biolog process predict hypertens relat target gene main relev nervous system develop cellular local regul cellular metabol process generat neuron posit regul biolog process b term cellular compon main relat membran bound organell cytoplasm intracellular membran bound organell synaps part neuron part nucleoplasm c term molecular function main relat protein bind transcript regulatori region dna bind rna polymeras ii regulatori region dna bind transcript regul activ ion bind kegg enrich analysi show p signal pathway adrenerg signal cardiomyocyt camp signal pathway tgf signal pathway endocrin factor regul calcium reabsorpt mtor signal pathway aldosteron regul sodium reabsorpt may relat occurr develop hypertens conclus signific differ express mirna peripher blood lymphocyt kazakh patient essenti hypertens healthi peopl differenti express mirna may relat occurr develop essenti hypertens kazakh howev under mechan need explor verifi
D019295;D035683
T123;T091;T114
36,319,097
effect mechan microrna chronic obstruct pulmonari diseas target pikr studi aim investig effect microrna mir chronic obstruct pulmonari diseas copd cigarett smoke extract cse treat airway smooth muscl cell asmc target phosphoinositid kinas regulatori subunit pikr regul ptenpikakt signal pathway copd mous model induc lipopolysaccharid lps combin passiv smoke model mir mimic mir inhibitor use intervent treatment pulmonari function group detect emka detector hematoxylin eosin stain use observ patholog chang score lung tissu express tnf il il bronchial alveolar lavag fluid balf detect elisa primari asmc isol cultur adher tissu cultur prolifer activ detect cck edu assay transwel wound heal assay use measur migrat asmc target relationship mir pikr valid doubl luciferas report gene assay express level mir pikr mrna lung tissu mice group detect quantit revers transcript polymeras chain reaction qrt pcr western blot use detect express level ki pnca pten p pik pik p p akt akt lung tissu asmc result show lung function signific reduc mir mimic group level pikr signific increas lung function mir inhibitor group signific improv result stain show obvious inflammatori cell infiltr mir mimic group compar model group lung histopatholog injuri signific reduc mir inhibitor group accompani decreas express ki pnca pik p akt increas pten p protein level reduc level tnf il il balf result doubl luciferas report gene assay show mirna could target bind pikr compar csemir nc group prolifer migrat asmc signific increas csemir group prolifer migrat asmc signific attenu csemir pcdna pikr group compar csemir group accompani decreas express ki pnca p akt increas pten p protein level result suggest mir activ ptenpikakt signal pathway target pikr promot occurr develop copd provid new evid use mir treatment copd
D035683;D029424
T123;T047;T114
36,319,096
feed rhythm entrain circadian metabol gene circadian clock brown adipos tissu central circadian clock feed rhythm coordin reset peripher circadian clock emerg evid suggest feed rhythm reset peripher circadian clock tissu specif manner studi aim determin whether feed rhythm regul circadian rhythm circadian clock metabol gene brown adipos tissu bat appli differ regimen time restrict feed trf wildtyp per defici cbl mice quantifi effect sex treatment durat constant light circadian clock circadian rhythm bat circadian clock metabol gene rt qpcr repres circadian clock gene bmal nrd dbp per repres metabol gene uncoupl protein ucp phosphofructo kinasefructos biphosphatas pfkfb control flux glycolysi pyruv dehydrogenas kinas isozym pdk gate tricarboxyl acid cycl carnitin palmitoyltransferas cpta control mitochondri fatti acid oxid result show daytim restrict feed drf moder shift phase bat circadian clock femal mice within result loss circadian rhythm dbp per transcript male drf induc de novo oscil ucp transcript shift phase repres metabol gene pfkfb pdk cpta h constant light known disrupt synchroni central circadian clock result show constant light promot phase entrain circadian clock drf bat abolish oscil metabol gene except pdk despit combin treatment per defici constant dark drf suffici drive circadian rhythm bmal dbp nrd ucp pfkfb cpta overal circadian clock bat weak adapt alter feed rhythm sex differ central circadian clock antagon drf entrain bat circadian clock wherea drf reset circadian rhythm metabol gene ucp pfkfb cpta circadian clock depend manner
D057906
T040
36,319,095
mitochondri calcium uniport knockdown hippocamp neuron improv learn memori dysfunct alzheim diseas mice alzheim diseas ad neurodegen disord serious affect health elder still irrevers recent studi indic mitochondri dysfunct direct reason promot develop ad mitochondri calcium uniport mcu locat inner membran mitochondria key channel mitochondri ca uptak abnorm mcu express result imbal mitochondri calcium homeostasi ultim lead mitochondri dysfunct purpos studi determin effect mcu knockdown ad hippocamp neuron learn memori function ad model mice lentivirus adeno associ virus use vector transfect shrna hippocamp neuron ht cell hippocampi amyloid precursor protein app presenilin ps tau ad transgen mice respect order interfer mcu express cellular activ ht cell detect mts method chang learn memori dysfunct apppstau ad transgen mice test maze morri water maze result show mcu knockdown revers cellular activ ht cell decreas amyloid beta protein okada acid oa knockdown mcu hippocamp neuron improv spontan altern spatial work memori decreas escap latenc increas time target quadrant number platform cross spatial refer memori apppstau mice studi suggest mcu knockdown hippocamp neuron anti ad effect expect new strategi prevent treatment ad
D000544
T047;T048
36,319,094
effect acut fear stress spatial memori neuron plastic medial prefront cortex mice purpos studi investig effect acut fear stress spatial memori neuron plastic medial prefront cortex mpfc neuron mice elucid mechan under mpfc plastic post stress memori regul male cbl mice week old random divid control group stress group foot shock stress appli establish acut fear stress model chang spatial memori examin morri water maze test dynam chang spike encod pyramid neuron gabaerg neuron prelimb cortex prl infralimb cortex il mpfc detect whole cell record result show acut fear stress signific enhanc percentag freez number freez reduc averag speed decreas escap latenc acquisit phase extend probe time first quadrant shorten probe time third quadrant probe trial increas inter spike interv energi barrier absolut refractori period gabaerg neuron prl pyramid neuron il decreas inter spike interv energi barrier absolut refractori period pyramid neuron prl gabaerg neuron il result suggest acut fear stress enhanc spatial memori mice elev excit function prl deterior excit function il under mechan may involv role mpfc microcircuitri plastic spatial memori stress
D009473;D065852
T043;T041;T042
36,319,093
distinct recruit dynam chandeli cell basket cell thalamocort input divers type gabaerg interneuron tend special inhibitori control various aspect cortic circuit oper among distinct interneuron type chandeli cell ie axo axon cell bona fide cell type specif innerv pyramid cell axon initi segment site action potenti initi chandeli cell specul exert ultim inhibitori control pyramid cell spike thus chandeli cell appear share multipl similar basket cell fire pattern fast spike molecular compon also potenti perisomat inhibitori control unlik basket cell howev synapt recruit chandeli cell littl known yet examin mediodors thalamocort input chandeli cell basket cell medial prefront cortex combin mous genet optogenet electrophysiolog approach demonstr thalamocort input produc initi weak facilit synapt respons chandeli cell enabl chandeli cell spike persist contrast thalamocort input evok initi strong rapid depress synapt respons basket cell basket cell fire initi input overal distinct synapt recruit dynam underscor differ chandeli cell basket cell suggest two type fast spike interneuron play differ role cortic circuit process physiolog oper
D009474;D017966
T025
36,319,092
dual regul qizhiweitong particl gastric motil model rat gastroparesi paper aim studi effect qizhiweitong particl qzwt gastric motil gastroparesi model rat provid theoret experiment basi clinic treatment rat gastroparesi model establish bilater inject hydroxydopamin substantia nigra male spragu dawley sd rat model rat receiv singl gastric feed mgkg qzwt continu administr mgkg qzwt per day day gastric motil measur gastric empti studi vivo digit x ray imag system vivo ex vivo gastric longitudin muscl contract record powerlab biolog signal acquisit system gastric myoelectr signal record wireless implant telemetri system protein express level proinflammatori proteas myometrium determin western blot result show singl administr qzwt dose depend inhibit contractil activ isol gastric strip normal rat singl administr qzwt inhibit vivo contract gastric smooth muscl gastric myoelectr signal control model rat gastric empti rate vivo ex vivo gastric motil gastric myoelectr signal model rat signific decreas compar control rat continu administr qzwt mark improv indic gastric motil function singl administr qzwt inhibit isol gastric muscl strip contract neither atropin nitric oxid synthas inhibitor pretreat affect qzwt inhibitori effect continu administr qzwt regul increas protein express level nitric oxid synthas cyclooxygenas model group result suggest clinic treatment singl administr qzwt may induc analges effect rapid inhibit gastric motil effect relat acetylcholin nitric oxid pathway long term treatment qzwt may amelior gastric motil enhanc myoelectr activ gastric smooth muscl contract gastric empti effect may part relat anti inflammatori effect
D018589;D004365
T123;T047;T121
36,319,066
toler efficaci target therapi prescrib label indic refractori system autoimmun diseas data first patient enrol tata registri target therapi autoimmun diseas assess toler efficaci target therapi prescrib label refractori low preval autoimmun inflammatori system diseas
D001327;D000086382
T047;T067
36,319,065
adapt singl kir nkgc nk cell expand select superdonor show potent miss self reactiv effici control hla mismatch acut myeloid leukemia natur killer nk cell hold great promis sourc allogen cell therapi hematolog malign includ acut myeloid leukemia aml current treatment hamper variabl nk cell subset respons limit could circumv specif expans high potent singl killer immunoglobulin like receptor kir nkgc adapt nk cell maxim miss self reactiv
D003602;D015470
T191;T043
36,319,064
deciph molecular cellular ex vivo respons bispecif antibodi pd tim pd lag human tumor next generat cancer immunotherapi design broaden therapeut repertoir target new immun checkpoint includ lymphocyt activ gene lag cell immunoglobulin mucin domain contain tim yet molecular cellular mechan either receptor function mediat inhibitori effect still poor understood similar littl known differenti effect dual compar singl checkpoint inhibit
D018033;D009369
T129;T121;T191;T116
36,319,063
mir b p modul function regulatori cell tumor microenviron target tnfr tumor necrosi factor receptor type tnfr primarili express cd foxp regulatori cell treg especi present tumor microenviron compel evid tnfr play crucial role activ expans phenotyp stabil treg promot tumor immun evas understand epigenet regul tnfr express treg may help devic novel strategi cancer immunotherapi
D000230;D003110;D035683
T123;T191;T114
36,319,062
tanshinon function coenzym confer gain function nqo suppress ferroptosi ferroptosi trigger breakdown cellular iron depend redox homeostasi abnorm accumul lipid ros cell evolv defens mechan prevent lipid ros accumul ferroptosi use librari bioactiv compound show tanshinon salvia miltiorrhiza danshen potent inhibitori activ ferroptosi mechanist found tanshinon function coenzym nad p h quinon oxidoreductas nqo detoxifi lipid peroxyl radic inhibit ferroptosi vitro vivo although nqo recogn oxid stress respons gene appear direct role ferroptosi inhibit absenc tanshinon demonstr gain function nqo induc tanshinon novel mechan ferroptosi inhibit use mous model acut liver injuri ischemiareperfus heart injuri observ tanshinon display protect effect liver heart manner depend nqo result link clinic use tanshinon activ ferroptosi inhibit
D000079403;D027561
T002;T043
36,319,061
c ognit utcom p ragmat nvestig optima l xygen arget co pilot trial protocol statist analysi plan long term cognit impair one common complic critic ill among survivor receiv mechan ventil recommend oxygen target mechan ventil vari among intern guidelin differ oxygen target mechan ventil potenti alter long term cognit function due cerebr hypoxemia hyperoxemia whether higher intermedi lower spo target associ better cognit function month follow unknown
D016638;D000070356
T047;T097
36,319,060
process evalu person news social media engag communiti base programm brown buttabean motiv bbm research protocol communiti group brown buttabean motiv bbm initi began assist auckland pasifika mori manag weight problem predomin communiti base exercis session social support bbm activ expand time includ mani compon healthi live respons communiti need advent covid pandem bbm outreach grew includ foodbank distribut increas amount donat healthi food famili need communiti kitchen influenza covid vaccin drive strong social media presenc serv main mean communic bbm communiti well use tradit news media written radio televis engag vulner member communiti
D061108;D000086382
T047;T170;T067
36,319,059
digit distribut yoga intervent breast cancer rehabilit digiyoga care protocol randomis control trial breast cancer preval cancer among women treatment extens addit surgeri various combin radiat therapi chemotherapi antibodi endocrin treatment appli cancer relat fatigu crf high patient breast cancer peak chemotherapi may persist sever year physic activ proven effect reduc crf breast cancer rehabilit mani patient tend less activ diagnosi yoga previous demonstr effect energi level digit distribut yoga intervent potenti increas access pandem time facilit particip patient suscept infect live far organis rehabilit opportun purpos studi digit yoga intervent cancer rehabilit digiyoga care investig whether week digit distribut yoga intervent reduc crf stress improv health relat qualiti life hrql affect pro inflammatori metabol marker patient breast cancer
D015013;D001943
T061;T191
36,319,058
preval awar treatment control type diabet determin among mongolian china cross section analysi imagin studi aim estim preval awar treatment control rate type diabet td pre diabet well identifi associ factor among mongolian live inner mongolia autonom region china
D003924;D011236
T047
36,319,057
methenamin hippur prevent recurr urinari tract infect older women protocol randomis placebo control trial impresu methenamin hippur urinari antisept use prevent treatment recurr urinari tract infect uti scandinavian countri howev scientif evid prevent effect safeti longer term use limit aim studi assess whether methenamin hippur reduc incid uti older women recurr uti
D008709;D014552
T121;T047;T109
36,319,056
associ urinari bisphenol concentr vitro fertilis outcom systemat review meta analysi protocol bisphenol bpa common environment endocrin disruptor bpa report associ femal infertil may affect natur pregnanc natur fertil also affect outcom vitro fertilis ivf bpa exposur may help part explain unsatisfactori ivf outcom relationship concentr bpa urin ivf outcom remain controversi therefor perform meta analysi identifi review relationship urinari bpa concentr ivf outcom
D005307;D007247
T061;T010;T033;T047;T046
36,319,055
qualit studi view peopl live cardiovascular diseas healthcar profession toward use digit platform support cardiovascular diseas self manag paper focus format research part broader studi develop evalu innov digit health platform self manag cardiovascular diseas cvd primari object better understand percept key stakehold toward propos platform salvio identifi develop consider may prioritis base experi cvd manag
D000073278;D002318
T058;T047
36,319,054
physician report barrier use evid base antibiot prescript guidelin primari care protocol systemat review synthesi qualit studi use theoret domain framework overprescript antibiot pose signific threat healthcar global contribut issu antibiot resist antibiot predomin prescrib bacteri infect often inappropri given uncompl upper respiratori tract infect urti relat condit common cold studi involv qualit systemat review physician report barrier use evid base antibiot prescript guidelin primari care set synthesis find use theoret basi
D000900;D010820
T121;T195;T097
36,319,053
associ sleep behaviour pattern risk glaucoma prospect cohort studi uk biobank given role intraocular pressur glaucoma patient sleep pattern might contribut develop progress glaucoma perform studi understand associ sleep behaviour glaucoma
D007319;D006970;D005901;D012893
T033;T184;T047;T048
36,319,052
benign paroxysm posit vertigo effect diagnosi treatment benign paroxysm posit vertigo bppv caus wayward crystal rock semicircular canal inner ear common caus brief symptom vertigo secondari head bodi movement diagnos treat simpl medic offic articl review differenti diagnosi patient present dizzi vertigo pathophysiolog bppv diagnos use maneuv elicit symptom nystagmus interpret nystagmus pattern determin rock treat use differ maneuv reposit roll rock back belong
D065635;D009759
T047
36,319,051
updat pneumococc vaccin adult simpler better recommend pneumococc vaccin adult updat hope prevent case invas pneumococc diseas also make recommend simpler easier follow
D014611;D011008
T061;T047
36,319,046
reduc risk breast cancer breast cancer remain common femal malign unit state reduc cancer burden involv identif high risk individu person risk manag coronari arteri diseas remain primari caus death women intervent reduc breast cancer risk must weigh comorbid intervent affect cardiovascular risk reduct select women increas risk breast cancer prevent medic great decreas risk vast underutil women health clinician pois evalu risk promot breast cancer risk reduct manag overal health
D001943
T191
36,319,045
geriatr updat prevent alzheim diseas articl publish contain import research relat prevent alzheim dementia relationship frailti social isol mortal covid risk patient dementia hospit home program deprescrib antihypertens drug bisphosphon relat atyp femor fractur cannabi use older adult
D000544;D000086382;D000073496
T184;T067;T033;T047;T046;T048
36,319,044
tumour induc osteomalacia due dural base intracrani phosphatur mesenchym tumour man refer persist hypophosphataemia boni pain serum fibroblast growth factor level mark elev diagnosi tumour induc osteomalacia consid whole bodi imag reveal multipl insuffici fractur osseus tumour howev dural base intracrani lesion whose imag characterist consist meningioma tumour remov lead rapid normalis patient symptom serum marker histolog confirm phosphatur mesenchym tumour review literatur regard rare clinic situat
D010018;D010257;D008637;D012983;D008577
T047;T191
36,319,041
uterin necrosi pregnanc follow exploratori laparotomi uterin necrosi infrequ event common report complic intervent postpartum haemorrhag manag case uterin necrosi pregnanc rare mainstay treatment uterin necrosi hysterectomi data regard conserv manag limit gravida para present week gestat ovarian torsion underw exploratori laparotomi ovarian cystectomi surgeri complic excess bleed control placement sutur along uterin bodi multipl subsequ present sever abdomin pain without clear aetiolog four week initi surgeri underw caesarean deliveri time uterin necrosi diagnos uterus preserv receiv postop intraven antibiot close observ continu well month postpartum patient uterin necrosi pregnanc haemodynam stabl conserv manag may option
D007813;D006473
T061;T058;T046
36,319,040
embolis iatrogen lumbar arteri bleed caus psoa haematoma follow elect lumbar punctur case femal patient present surgic emerg abdomin pain posit obraztsova sign seven day prior present lumbar punctur lp perform investig sever headach exclud subarachnoid haemorrhag patient subsequ found acut lumbar arteri bleed caus haemodynam instabl psoa haematoma emerg lumbar arteri embolis procedur perform intervent radiolog depart order stabilis bleed patient made full recoveri prior discharg
D013129;D013345
T060;T047;T046
36,319,039
gemcitabin induc digit ischaemia patient metastat breast cancer woman human epiderm growth factor receptor posit estrogenprogesteron receptor negat metastat invas ductal carcinoma breast present acral cyanosi sever throb pain recent administr gemcitabin treat aspirin heparin amlodipin topic nitroglycerin analges gemcitabin discontinu perman gradual recoveri except small necrot area right th digit howev surgic intervent avoid
D001943;D018270
T191
36,319,038
rare extens pancreat pseudocyst mycobacterium abscessus iliopsoa muscl pancreat pseudocyst well known complic acut chronic pancreat although extens anatom site common extens retrofasci space caus iliopsoa abscess exceed rare although low incid creat diagnost challeng clinician earli diagnosi essenti prevent signific complic poor patient outcom present case iliopsoa abscess unusu cultur fluid growth set acut chronic pancreat secondari extens pancreat pseudocyst also offer brief review literatur pathophysiolog condit
D010192;D000073358;D016659;D050500
T047;T007
36,319,037
subacut present mycoplasma homini prosthet valv endocard mycoplasma homini rare import caus prosthet valv endocard usual associ acut progress symptom difficult diagnos grow standard cultur media report case immunocompet man present month subacut declin short breath evid splenic infarct follow redo aortic valv replac diagnosi homini ribosom ribonucl acid pcr improv clinic oral doxycyclin therapi remain well follow year post cessat antibiot present literatur review highlight role pcr test microbiolog identif homini
D004697;D006350;D009175;D004696
T047;T074
36,319,036
evalu microperfor hymen lead incident diagnosi borderlin ovarian tumour microperfor hymen rare anatom variant unknown incid report case borderlin ovarian tumour similar uncommon incid approxim concurr presenc microperfor hymen borderlin ovarian tumour therefor exceed uniqu document case date report review case nullipar woman late initi present inabl penetr intercours subocclus hymen variant note examin imag work result incident discoveri larg ovarian mass subsequ note borderlin ovarian tumour herein review contemporari approach diagnosi manag hymen variant borderlin ovarian tumour discuss fertil spare strategi young women diagnos ovarian neoplasm
D014623;D010051
T047;T191
36,319,035
rituximab steroid resist organis pneumonia woman rheumatoid arthriti organis pneumonia op form interstiti pneumonia characteris inflamm scar lead obstruct within small airway alveoli practic guidelin recommend treatment moder sever op glucocorticoid howev case steroid resist op success treat rituximab describ case woman rheumatoid arthriti present pleurit chest pain haemoptysi dyspnoea exert diagnos op multipl radiograph imag biopsi patient fail numer treatment regimen includ corticosteroid antibiot mycophenol success treat rituximab case highlight import identifi new therapeut agent minimis use glucocorticoid treatment op
D018549;D011014;D001172
T047;T050
36,319,034
concomit giant pure intradiplo cavern haemangioma multifoc neurotoxoplasmosi pure calvari intradiplo cavern haemangioma pich rare benign tumour account bone tumour benign skull tumour general small slow grow asymptomat lesion author describ immunocompromis patient concomit giant intradiplo ossifi globular cavern angioma multifoc neurotoxoplasmosi underw combin approach treat lesion en bloc resect right pariet intradiplo lesion biopsi left occipit subcort lesioninde essenti exclud presenc metastas make time differenti diagnosi en bloc surgic resect pure intradiplo ossifi cavern angioma gold standard treatment prognosi complet excis usual excel rarer recurr rate
D016781;D006392;D012888;D001859
T047;T191
36,319,033
commerci determin indigen health well systemat scope review health inequ within indigen popul widespread underpin coloni dispossess oppress social cultur determin indigen health well well describ despit emerg literatur commerci determin health health well impact commerci activ indigen popul well understood aim identifi map synthesis avail evid commerci determin indigen health well
D000081034;D000431
T121;T098;T109
36,319,032
social dimens communiti deliveri intermitt prevent treatment malaria pregnanc madagascar mozambiqu nigeria democrat republ congo intermitt prevent treatment pregnanc sulphadoxin pyrimethamin iptp key malaria prevent strategi sub saharan african countri conduct anthropolog studi part project aim evalu communiti base approach deliveri iptp c iptp communiti health worker chws four countri democrat republ congo madagascar mozambiqu nigeria understand social context order identifi key factor could influenc c iptp accept
D000962;D008288
T121;T047
36,319,031
risk factor communiti acquir bacteri infect among young infant south asia longitudin cohort studi nest case control analysi risk factor predispos infant communiti acquir bacteri infect first month life poor understood south asia identifi risk factor infect could lead improv prevent measur antibiot stewardship
D017714;D001424
T047
36,319,030
barrier facilit hiv syphili rapid diagnost test antenat care set low incom middl incom countri systemat review test treatment pregnanc well establish cost effect prevent strategi reli larg use rapid diagnost test rdts yet mani low incom middl incom countri uptak rdts suboptim qualit meta synthesi conduct identifi barrier enabl use hiv syphili rdts among pregnant women low incom middl incom countri
D013587;D011251;D015658
T047
36,319,028
cascad decis meet person prefer sciatica treatment decis depth interview studi includ patient general practition neurologist neurosurgeon
D012585;D058005
T184;T097
36,319,027
health care util differ first nation peopl general popul inflammatori bowel diseas retrospect cohort studi saskatchewan canada indigen peopl canada often face barrier access special care limit data evalu health care util among indigen peopl inflammatori bowel diseas ibd aim compar health care util first nation patient general popul diagnos ibd saskatchewan
D000081034;D015212
T047;T098
36,319,026
prostat cancer incid among immigr men ontario canada popul base retrospect cohort studi prostat cancer incid associ various sociodemograph factor race incom age associ immigr status canada unclear popul base studi ontario canada compar age standard incid rate immigr male various region origin rate long term resid
D054242;D011471
T098;T191
36,319,025
associ goal care design order health care resourc use among serious ill older adult acut care multicentr prospect cohort studi goal care design gcd medic order use communic focus patient care alberta canada studi aim determin associ gcd type resuscit medic comfort resourc use hospit
D010347;D003422
T058
36,318,984
rgs ilrapl missens variant implic defect neurotransmiss earli onset inherit schizophrenia schizophrenia character hallucin delus disorgan behaviour recess x link transmiss rare describ common psychiatr disord examin genet psychosi identifi rare larg effect variant patient extrem schizophrenia
D012559;D020710
T123;T116;T048
36,318,983
alter coordin frontal delta pariet alpha network under anhedonia depress rumin major depress disord hyperact default mode network dmn observ peopl major depress disord mdd weak dmn suppress link depress symptom howev whether dysregul dmn contribut blunt posit emot experi peopl mdd unclear
D003865
T048
36,318,979
novel antihyperglycaem drug prevent chronic obstruct pulmonari diseas exacerb among patient type diabet popul base cohort studi determin whether use glucagon like peptid glp receptor agonist dipeptidyl peptidas dpp inhibitor sodium glucos co transport sglt inhibitor separ associ decreas risk exacerb chronic obstruct pulmonari diseas among patient chronic obstruct pulmonari diseas type diabet
D003924;D054873;D000077203;D029424
T121;T047;T109
36,318,974
diffus coeffici intracrystallin water intrins hen egg white lysozym crystal determin confoc raman spectroscopi protein crystal compos protein molecul expect novel porous materi high poros knowledg diffus intracrystallin water import studi diffus coeffici intracrystallin water intrins hen egg white lysozym hewl crystal determin method combin confoc raman spectroscopi air convect control relat humid similar common porous materi dri process protein crystal includ three period constant rate dri fall rate dri equilibrium state fall rate dri period dri rate depend diffus intracrystallin water protein crystal gradient water content measur use confoc raman spectroscopi diffus coeffici intrins hewl crystal determin cm water content vol estim diffus coeffici intrins hewl crystal without cross link close agreement cross link protein crystal studi time knowledg intrins diffus coeffici use understand mechan hydrat protein also practic applic porous materi drug bind cryoprotect soak
D009113;D014867
T121;T197;T126;T116
36,318,953
comparison sens humor burnout surgeon intern medicin physician aim evalu humor style surgeon internist investig associ humor burnout
D002055;D066231
T097;T048
36,318,952
readmiss risk covid hospit moder analysi vital sign readmiss hospit hospit coronavirus diseas covid associ signific morbid mortal hospit clinician may identifi presenc patient comorbid condit overal sever ill clinic status discharg risk factor readmiss object data lack support relianc factor discharg decis make object studi examin risk factor readmiss hospit covid hospit impact vital sign abnorm within hour discharg readmiss rate
D000086382;D009203
T047;T067
36,318,951
gallbladd dyskinesia gallbladd dyskinesia function disord gastrointestin tract result debilit episod abdomin pain associ symptom key diagnost criteria includ diminish gallbladd eject fraction scintigraphi absenc caus symptom patholog find follow suggest distinct mechanist basi condit unfortun complex diagnosi treatment combin patient provid prefer like continu preclud random control studi provid clearer evid base manag disord patient meet clinic diagnost criteria gallbladd dyskinesia refer cholecystectomi patient relief symptom comprehens preoper discuss expect outcom need take place
D001657
T047
36,318,950
glasgow blatchford bleed score poor predictor endoscop intervent nonvaric upper gi bleed recent data show glasgow blatchford bleed score gbs identifi patient upper gastrointestin gi bleed benefit inpati esophagogastroduodenoscopi egd studi aim determin rate endoscop hemostat intervent hi patient nonvaric acut gi bleed nvaugib admit gbs secondari aim includ comparison clinic outcom patient without hi cost nontherapeut egd
D006471;D006760
T047;T046;T058
36,318,948
primari care clinician perceiv role address childhood obes southern unit state primari care opportun set promot healthi behavior children famili expert committe recommend pediatr primari care clinician assess nutrit physic activ well visit offer recommend howev littl known pediatr primari care clinician perceiv role childhood weight manag qualit studi aim describ perceiv role pediatr primari care clinician prevent treatment childhood obes south carolina state southern unit state high rate childhood obes
D063766
T033;T047
36,318,947
examin stillbirth workup rural statewid experi object studi determin whether recommend assess conduct stillbirth deliv predomin rural state
D050497;D010920
T033;T018
36,318,946
associ earli interest orthoped surgeri match rate orthoped surgeri orthoped surgeri resid consid one competit specialti match studi examin factor associ success match neglect whether particip orthoped interest group oig improv chanc orthoped resid match goal studi test hypothesi particip oig would improv match orthoped surgeri resid
D019637;D007396;D000073978;D002982
T061;T065;T097;T080
36,318,945
particip longitudin seminar seri increas medic student engag covid pandem coronavirus diseas covid pandem requir multifacet respons healthcar profession medic student play limit role earli respons result feel disengag author develop discuss base elect cours review covid respons address gap medic student educ
D013337;D000086382;D004501
T065;T047;T067;T097
36,318,943
trend icd cm code administr dataset injuri surveil research accur injuri surveil depend data qualiti administr dataset creat bill reimburs signific effort devot test abil candid injuri case definit identifi injuri case accur dataset use interview experienc coder inform review current literatur identifi three clinic code trend may affect consist surveil data clinic document improv clinic document integr cdi code treat clinician certain electron health record featur
D038801;D006278
T064;T089;T170
36,318,913
suicid behavior suicid complex phenomenon help profess like confront issu articl aim provid inform suicid context mental ill prevent provid recommend
D013405;D001523
T033;T048
36,318,912
e cigarett mean smoke cessat sever year declin tobacco consumpt number smoker germani current stagnat rise reason seem manifold e g stress caus pandem social isol rise cost live war europewith tobacco use still widespread german popul evid base tobacco cessat rare implementedaccord recent studi e cigarett involv pathogenesi lung diseas cardiac vascular damag addit ingredi also carcinogen effect howev clinic studi long term use yet available cigarett consum product superior nicotin replac product addict reduc medic recommend guidelin therapeut set slight effect nicotin replac product howev usual consum continu thus perpetu nicotin depend use increas risk relaps tobacco smokingdespit various new approach internet base offer app etc talk pharmacotherapi gold standard effect therapi
D016540;D066300;D014029
T055;T073;T048
36,318,911
treatment strategi diabet nephropathi updat new classif patient diabet mellitus call cluster use assess risk develop diabet nephropathi date treatment patient diabet nephropathi includ glycem control focus holist approach prevent progress secondari diabet complic reduct patient cardiovascular mortal
D003928;D003924
T047
36,318,909
law emerg represent intens care medicin case patient incap decisionmak familiy member authoris repres decisionmak accord presum patient submit written health care disposit appoint guardian court urgent case court also enforc patient right self determin rule bgb german civil code effect spous law automat becom repres matter health care howev new regul contain number condit reserv well rais question implement clinic practic
D026684;D003422
T078;T058
36,318,908
season influenza updat epidemiolog prevent therapi infect control measur travel restrict implement covid pandem limit transmiss season influenza virus well must assum public health measur larg lift influenza activ sharpli increas come influenza season anticip potenti high number case co circul influenza virus sar cov effort increas vaccin rate infecti diseas must given attent
D007251;D000086382;D007252
T129;T121;T067;T109;T047
36,318,907
aggress lymphoma dlbcl mcl new understand molecular basi develop progress malign lymphoma signific improv last decad lead identif genet alter proven prognost impact clinic cours diseas tp mutat mcl deepen molecular understand set basi current rapid develop regard target immuno base therapi offer individu risk adapt treatment strategi near futur potenti improv patient carethes new therapeut altern integr first line treatment dlbcl mcl among other potenti replac convent chemotherapi base treatment strategi yet despit promis new develop clinic cours patient primari refractori diseas earli relaps month still character moder respons limit overal surviv even upon treatment avail target treatment altern high risk patient optim individu therapeut strategi high warrantedthi articl summar new find regard tumor biolog actual develop expand therapeut landscap dlbcl mcl
D000971;D008228
T061;T191
36,318,906
multimorbid patient care definit strategi limit challeng multimorbid occurr multipl medic condit lie complex consid type sever interact patient social status characterist although number combin appear unlimit emerg call multimorbid pattern group diseas often coincideth preval multimorbid increas dramat demograph chang medic progress lead explod cost healthcar definit therapeut approach field ambigu also lack establish assessmentth complex need patient multimorbid address appropri establish one diseas approach clinic guidelin suggest conflict treatment strategi result decis dilemma daili worktim communic decis adapt patient situat key success treatment multimorbid integr approach must base comprehens geriatr assess action strategi integr guidelin need support clinician decis make process furthermor clinic studi includ older adult multimorbid particular consid relev outcomesgerosci new research area address hallmark age therapeut approach delay even avoid onset multimorbid
D000076322;D000375
T078;T033;T040
36,318,905
endocrin disrupt chemic endocrin disrupt chemic edc univers occur substanc potenti interrupt hormon system although definit edc yet standard similar hormon edc potenti abl act low concentr might consid save toxicolog viewpoint research past year show edc even low dose might relev impact human health environ wellth increas diseas burden disabl induc edc caus substanti cost societi thus besid implic person global health edc affect economi well pose univers threat societi environ mani potenti hazard substanc still inadequ examin regulatedin review give brief summari previous effort classifi edc provid short summari current knowledg
D052244
T131;T039
36,318,904
peripher arteri diseas diabet mellitus patient peripher arteri diseas diabet mellitus vulner increas risk morbid amput mortal compar non diabet patient peripher arteri diseas despit huge effort health care system diabet mellitus still repres import risk factor also peopl peripher arteri diseas regardless presenc diabet mellitus peopl often awar peripher arteri diseas achiev optim therapi peopl peripher arteri diseas consult angiologist vascular surgeon aim reduc morbid mortal prevent earli detect optim therapi peripher arteri diseas diabet mellitus crucial factor adequ health care manag
D058729;D003920
T047
36,318,862
descript prove intent homicid involv poison substanc relationship medic procedur context purpos studi provid descript prove intent homicid involv poison substanc base structur analysi medic crimin procedur criteria relev process practic basi research statist analyt materi ministri intern affair ukrain nation polic ukrain prosecutor general offic state judici administr ukrain summar data studi materi crimin proceed primarili resolut appoint forens examin materi mass media result research establish medic descript concept poison possibl variant use urgent need includ implement version procedur pre trial investig well establish ident perpetr list similar offens commit similar way view scientist understand concept poison includ lethal agent character number explan regard use special knowledg pre trial investig intent homicid involv poison substanc also provid
D057237;D011042
T131;T098
36,318,861
analysi antibiot resist condit pathogen oropharyng microflora children viral respiratori infect purpos compar antibiot resist oropharyng normoflora children frequent viral respiratori infect vris investig children children treat infecti diseas depart ternopil region ukrain children clinic hospit obtain materi oropharynx examin conting studi general accept microbiolog method determin antibiot suscept select strain perform method standard disk among survey children year carrier staphylococci children actual aureus differ type streptococci isol almost half patient subject hemolyt hemolyt patient vris aureus analysi antibiot suscept staphylococci streptococci reveal signific reduct number suscept staphylococc strain cephalosporin penicillin moder aminoglycosid chloramphenicol almost studi microorgan insensit erythromycin past year number staphylococc strain sensit ceftriaxon decreas chloramphenicol ampicillin number streptococci sensit group antibiot decreas compar ampicillin number sensit strain decreas
D013211;D012141
T047;T007
36,318,860
clinic function state thyroid gland women peri postmenopaus age metabol syndrom articl deal problem clinic function relationship state thyroid gland women menopaus age compon metabol syndrom ms purpos studi assess relationship thyroid dysfunct various compon ms women peri postmenopaus age menopaus women mean age year examin peopl ms constitut main group comparison group similar number women without ms inclus criterion studi presenc sign abdomin obes ao accord criteria anthropometr function bp laboratori lipidogram tsh freet antibodi tpo fsh lh urinari iodin concentr instrument ultrasound thyroid gland data statist analysi use program spssstatist version evalu women divid two age group group perimenopaus group postmenopaus peopl group women ms women without ms shown peri postmenopaus women ms subclin hypothyroid influenc peripher blood tsh level peri postmenopaus women ms bodi weight carbohydr lipid metabol sex hormon establish
D024821;D007037
T047
36,318,859
use adrenoblock patient heart failur concomit thyroid patholog literatur review observ systemat literatur data use adrenoblock patient heart failur concomit thyroid patholog carri result studi present suggest final chapter histori use adrenoblock patient heart failur reduc left ventricular eject fraction thyroid patholog yet written studi need includ pharmacogenet one use select adrenoblock bisoprolol patient chronic heart failur reduc left ventricular eject fraction concomit low triiodothyronin syndrom lead decreas frequenc rehospit due decompens time frequenc rehospit group patient heart failur without low triiodothyronin syndrom higher dose mg bisoprolol compar higher dose effect bisoprolol revers patient low triiodothyronin syndrom risk hospit increas dose bisoprolol exceed decreas serum level triiodothyronin increas thyroxin level decreas ratio triiodothyronin thyroxin increas caviti heart decreas size probabl patient heart failur background low triiodothyronin syndrom advis titrat dose bisoprolol mg time titrat drug indic dose day today argu general recommend use adrenoblock patient chronic heart failur reduc left ventricular eject fraction appli patient concomit thyroid dysfunct subject restrict
D006333;D005067
T047;T046
36,318,858
pneumonia among children year age analysi incid hospit mortal republ kazakhstan aim analyz dynam morbid mortal pneumonia children year age republ kazakhstan year sinc introduct vaccin pneumococc infect nation immun schedul republ kazakhstan retrospect cross section studi carri use statist collect nation scientif center health develop name kairbekova criterion studi epidemiolog incid pneumonia children year age per children indic compar year incid decreas case amount case case analyz lethal children pneumonia region also decid show top region high rate list includ akmola n turkestan n west kazakhstan n kostanay region n citi nur sultan citi astana n indic republ case per children incid per children region citi higher republican indic kazakhstan incid pneumonia children year old per children case region akmola turkestan north kazakhstan kostanay zhambyl region indic highest countri incid pneumonia children year age tend decreas kazakhstan howev citi almati show relat high proport total mortal diseas year age work analyt work studi immun children pneumococc infect requir full studi curv plot parent refus vaccin given period time
D011014;D011008
T047;T050
36,318,857
signific ischemia prolif activ mucosa inflammatori bowel diseas state microcirculatori bed remain one determin factor cours inflammatori bowel diseas ibd presenc small foci ischemia could realiz dystroph necrobiot consequ also underli develop strengthen inflammatori process base goal studi determin impact develop mucos ischemia colon activ prolif process inflamm studi perform adult wag rat model ibd oral administr solut dextran sulfat sodium serial slide colon made stain hematoxylin eosin accord rego immunohistochem examin ihc ki volum ischem area ki express detect statist comparison perform inspect microscopi dss experiment group determin alter desquam chang surfac epithelium epithelium intestin gland crypt diffus polymorph cellular infiltr mucous membran place spread submucos base morpholog manifest ibd foci ischemia detect group volum microfoc chang observ intact anim p detect prolif activ depend ischem sign realiz differ level ki express lowest level ki estim mucosa ischemia pronounc express ki observ ibd group area connect ischemia even p ki strong express epitheli cell colon intact tissu model ibd signific increas express twice inflammatori group p spread activ process uneven collat slide ich rego stain realiz estim strong negat correl ki express ischemia r
D015212
T047
36,318,856
diseas oral mucosa patient post covid period impact sar cov sever acut respiratori syndrom relat coronavirus entir human bodi caus irrevers chang organ system complic form chronic diseas requir treatment clinician various field medicin dentist face diseas oral mucosa appar healthi patient predispos undergon covid purpos studi assess impact coronavirus infect covid cours diseas oral mucosa examin patient age undergon covid various diseas oral mucosa studi use clinic laboratori method featur clinic cours certain diseas oral mucosa reveal dynam local immun defens oral caviti post covid period determin
D000086402;D000086382
T005;T067;T047
36,318,855
sentinel lymph node detect method breast cancer million case breast cancer regist figur indic diseas widespread lymphat metastasi one import caus local recurr breast cancer unfavor factor prognosi purpos work improv algorithm intraop diagnosi sentinel lymph node patient breast cancer patient tnm breast cancer oper odesa region clinic hospit two type dye patent blue icg use patient mastectomi sentinel lymph node biopsi rule clinic diagnosi tnm breast cancer group patient sentinel lymph node biopsi stain lymph node perform use patent blue group sentinel lymph node biopsi conduct use patent blue anoth fluoresc dye icg also administ subderm total five year surviv rate axillari lymph dissect sentinel lymph node biopsi respect five year recurr free surviv rate axillari lymph dissect approxim sentinel lymph node biopsi region recurr sentinel lymph node affect side found case sentinel lymph node intact patient next lymph dissect perform affect lymph node observ patient time follow rang month recurr regist studi reveal differ total recurr free surviv rate group detect mts lesion inguin sentinel lymph node oper continu obligatori determin second third order lymph node extent surgic intervent determin oper tabl base result intraop histolog examin fluoresc lymphographi method high accuraci allow recommend implement clinic practic
D000071036;D001943
T023;T191
36,318,854
featur anatom lesion coronari arteri depend level st troponin blood plasma patient nstemi aim studi evalu depend associ st troponin level natur anatom lesion coronari arteri examin patient nstemi age year urgent hospit vinnytsya region clinic center cardiovascular patholog patient underw laboratori test st troponin level plasma enzym link immunosorb assay first day hospit coronari angiographi associ relat high level st relat high level troponin posit correl degre coronari arteri damag associ relat low level st troponin sever stenot coronari arteri lesion rule determin associ st troponin coronari angiographi allow predict degre stenot lesion coronari arteri determin expect intervent strategi patient nstemi
D000072658;D009203
T047
36,318,853
studi assess serum adropin level risk factor ischaem heart diseas type diabet mellitus case adropin peptid hormon first identifi first thought signific role balanc fatti acid glucos peripher tissu look relationship adropin diabet individu ischem heart diseas object studi evalu serum adropin level potenti indic ischem heart diseas peopl type diabet mellitus particip case control studi split three group group consist tdm patient ischem heart diseas group ii consist tdm patient without ischaem heart diseas group iii consist healthi person control group hbac lipid profil cholesterol triglycerid ldl c hdl homa ir serum creatinin ast alt serum adropin also evalu fast plasma glucos h postprandi plasma glucos carotid arteri intim thick use ultrasound carotid arteri intim thick also measur patient diabet ischem heart diseas statist signific rise serum adropin hormon p valu valu ngl ngl respect addit bad correl serum adropin cimt fast insulin assess serum adropin level may serv risk indic emerg ischem heart diseas peopl type diabet mellitus
D003924;D017202
T047
36,318,852
influenc ad zinc arginyl glycin improv efficaci bioregulatori peptid prostat gland treatment patient impair sperm paramet drug prostatilen ac rectal suppositori develop basi previous regist medicin contain bioregulatori peptid prostat gland prostatilen rectal suppositori mg differ addit ctive pharmaceut ingredi zinc arginyl glycin dihydrochlorid zag aim studi analyz posit effect ad zag drug patient impair spermatogenesi total men age year averag year verifi diagnosi chronic abacteri prostat relat reproduct dysfunct phase iii random multicent open label clinic trial examin durat particip patient studi day screen period day durat therapi day final examin day studi group n receiv therapi prostatilen ac daili control group n prostatilen daili patient underw convent semen analysi treatment obtain paramet compar analysi averag statist data comparison group found treatment prostatilen ac lead increas total popul motil spermatozoa cell b c refer drug prostatilen contribut increas indic compar result screen examin signific higher effici increas relat count spermatozoa fast progress motil therapi prostatilenprostatilen ac p prostatilen ac show signific higher effici term increas count normal form spermatozoa ejacul refer drug prostatilen therapi prostatilenprostatilen ac p patient receiv drug prostatilen ac number abnorm form spermatozoa decreas therapi comparison group drug prostatilen therapi signific decreas form abnorm spermatozoa head acrosom neck patholog prostatilen ac compar control prostatilen ac compar prostatilen statist signific clinic signific superior efficaci relat initi impair sperm paramet improv sperm motil restor morpholog normal sperm decreas form abnorm spermatozoa head acrosom neck patholog drug could recommend use treatment patient chronic prostat occur concomit disord sexual reproduct function
D011472;D000072660
T033;T047
36,318,851
covid infect third trimest pregnanc obstetr outcom current relat effect pandem pregnanc question certainti real impact covid pregnant women studi updat often contradict evid suggest pregnant women covid higher morbid affect non pregnant women aim know whether matern morbid frequent pregnant woman covid compar non infect pregnant women retrospect case control studi conduct period month medic record review file covid infect women mosul citi file non infect pregnant women review analyz found infect covid signific effect pregnanc outcom infect women like higher incid rate advers perinat outcom mother newborn also higher odd complic associ sever diseas form find studi came line previous studi countri howev medic care support provid pregnant women infect covid particular sever case studi larger sampl size still need good understand effect virus pregnanc outcom
D000086382;D011251
T047;T067
36,318,850
evalu sexual function transgend gender divers individu call action sexual function key factor impact individu wellb includ transgend gender divers tggd popul lack valid sexual function evalu tool communiti contribut gap medic knowledg barrier proper assess intervent understand sexual function expect pre post gender affirm surgeri gas current studi indic benefici individu treatment manag sexual dysfunct tggd individu demonstr import applic valid sexual function assess evalu sexual function patient essenti consid social mental physic compon experienc communiti well variat sexual practic prefer current due general lack index assess provid andor research left adapt one valid cisgend tool creat non valid evalu tool assess tggd patient creation uniqu valid sexual function tool provid abl improv affirm patient care reduc stigma ensur accur sexual function evalu
D063106;D014189
T032;T098
36,318,849
psychophysiolog correl student well armenia articl focus develop model psychophysiolog base well psychophysiolog featur well armenian student investig diagnosi well use whoqol indic function state regist indic heart rate variabl student particip anonym research purpos studi identifi relationship student psycholog wellb physiolog indic indic physic health sampl consist voluntari respond differ hei high educ institut armenia femal age year median age particip anonym research first stage student answer whoqol question questionnair measur qualiti life function indic regist laboratori sport cab armenian state institut physic cultur sport identifi relationship indic function state physiolog indic compon well student ra pearson correl analysi perform psycholog well posit correl tension indic high frequenc indic negat correl found almost indic psycholog compon well interest fact reliabl link found physiolog indic well social relat obtain correl studi indic psycholog well physiolog indic allow us consid indic cardiovascular system factor physic health also compon psycholog well
D011788;D013334
T078;T081;T098
36,318,848
distribut frequenc blastocysti sp method microscopi cultiv faec resid kharkov region blastocysti sp preval anaerob intestin protozoan parasit human mani anim billion peopl world colon pathogen blastocysti sp found faecal sampl fs healthi peopl asymptomat person patient symptomat person nonspecif symptom gastrointestin tract skin joint organ lesion preval peopl affect blastocysti sp cohort world vari wide depend degre countri econom develop sanitari hygien condit cultur valu etc current microscop cultur immunolog molecular genet method use blastocysti sp detect stool sampl group method blastocysti sp detectionidentif fs advantag disadvantag goal studi determin preval blastocysti sp faecal sampl differ cohort peopl clinic healthi symptomat peopl symptom gastrointestin lesion kharkiv microscop cultur method cohort survey resid kharkiv n includ clinic healthi individu symptomat individu gastrointestin tract diseas fss precipit subject microscop examin formalin phosphat salt buffer fpbscs enrich concentr procedur ph g minut blastocysti sp identif carri mean microscopi faecal smear stain wheatley modif trichrom stain mwts heidenhain iron hematoxylin stain hih inocul materi filter suspens nativ fs l inocul ml liquid media rpmiimdmem mixtur equal volum rpmi imdmem media antibiot serum blastocysti sp cultur growth carri anaerob condit oc day blastocyst final identif carri mean light microscopi suspens smear stabli stain mwts hih carri compar evalu effect blastocysti sp detect method microscopi smear enrich faecal materi stain mwts hih cultiv rpmiimdmem medium base result parallel studi fs differ group peopl method insignific increas blastocysti sp frequenc detectionidentif mean cultur method comparison frequenc microscop parasit detect fs determin fs asymptomat individu n fs symptomat individu n p fs blastocysti sp detect microscop growth parasit primari cultur obtain among total result negat posit blastocysti sp detect identif microscop cultur method fs human rf reach group fs asymptomat symptomat individu rf rf respect sampl posit result detect identif blastocysti sp microscop cultur method valu rf studi fs human fs asymptomat individu fs symptomat individu accord result parallel studi microscop cultur method fs differ group peopl found cultur method domin microscop sensit blastocysti sp detect fs character much higher level specif accuraci parasit identif reach method vitro diagnost help increas effici parasit detect human fs use epidemiolog studi establish popul preval protozoa determin sensit blastocysti sp cultur drug control etiotrop blastocystosi therapi effect obtain parasit antigen studi diseas pathogenesi virul potenti pathogen strain differ origin etc
D016844;D016776
T047;T204