PMID
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36.4M
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36,313,229
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role c abl postop neurodegener nonreceptor tyrosin kinas c abl inact normal condit upon activ c abl regul signal pathway relat cytoskelet reorgan play vital role modul cell protrus cell migrat morphogenesi adhes endocytosi phagocytosi larg number studi also found abnorm activ c abl play import role varieti patholog includ various inflammatori diseas neurodegen diseas c abl also play crucial role neurodevelop neurodegen diseas main mechan neuroinflamm oxid stress os tau protein phosphoryl inhibit express activ kinas certain neuroprotect anti inflammatori effect also improv cognit behavior blocker kinas may good prevent treatment effect neurodegen diseas cognit dysfunct anesthesia also close relat abovement mechan infer alter express activ c abl may underli postop cognit dysfunct pocd articl summar current understand research progress mechan c abl may relat postop neurodegener
|
D016315;D019636
|
T047;T126;T116
|
36,313,228
|
transcriptom analysi patient asthma inhal combin therapi long act agonist corticosteroid introduct asthma one major public health problem impos great burden societ financi healthcar around world asthma poor affect health relat qualiti life daili activ patient treatment asthma includ inhal corticosteroid ic long act beta agonist laba main aim improv lung function reduc symptom exacerb current treatment regimen symptom base strategi status airway inflamm treatment yet unknown conduct studi understand comprehens inflamm airway remodel status patient ic laba treatment rna transcriptom analysi materi method eight newli diagnos asthmat patient two healthi subject recruit studi asthmat patient underw blood test lung function test rna transcriptom analysi ic laba treatment result comparison healthi subject pretreat asthmat patient higher express protein tyrosin kinas relat signal pathway ic laba treatment express nuclear receptor transcript coactiv n acetyltransferas protein tyrosin kinas nuclear receptor rna polymeras ii activ transcript factor downregul howev post treatment asthmat patient still higher express cystein type endopeptidas endodeoxyribonucleas apolipoprotein unfold protein still upregul healthi subject conclus combin icslaba decreas airway inflammatori remodel pathway howev allergen stimul relat pathway still upregul patient icslaba treatment combin medic allergen remov complet strategi asthma
|
D011788;D001249
|
T078;T047
|
36,313,227
|
applic artifici intellig diagnos covid diseas symptom chest x ray systemat review systemat review focus use artifici intellig ai detect covid infect help x ray imag methodolog januari author search pubm embas scopus use specif medic subject head term filter articl independ review two review conflict result misunderstand resolv third independ research assess abstract articl use elimin repetit appli inclus exclus criteria six studi found qualifi studi result find individu studi differ due various approach author sensit specif precis accuraci area curv conclus ai comput model use assess chest x ray process diagnos covid achiev suffici high sensit specif result perform repeat make depend clinician moreov addit diagnost tool afford faster current avail procedur perform calcul ai base system take clinic data account
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D000086382
|
T047;T067
|
36,313,226
|
effect ozon cold plasma regener crush mental nerv injuri rat background experiment research aim determin whether ozon cold plasma ncp regen effect crush injur sensori nerv rat model wistar evalu whether ncp use altern treatment method sensori nerv injuri oral maxillofaci region method total wistar rat use experi divid three group accord whether mental nerv left mandibl injur ncp appli group n non mental nerv damag non md left mental nerv expos non damag group n mental nerv damag md left mental nerv expos damag ncp appli group n mental nerv damag ncp md ncp left mental nerv expos damag ncp appli regular interv three time week result behavior analysi von frey test use furthermor nerv tissu examin hematoxylin eosin h e stain extent neurorecoveri evalu immunofluoresc stain certain marker behavior analysi show function recoveri sensori nerv faster group md ncp histomorpholog immunofluoresc analys express factor involv neurorecoveri much higher group group md conclus expediti recoveri sensori nerv function well higher express factor indic nerv function recoveri ncp treat group suggest ncp posit effect regener sensori nerv crush injuri therefor case sensori impair oral maxillofaci region ozon cold plasma appli therapeut effect
|
D058626;D010126;D000080902;D000071576;D059348
|
T104;T103;T037
|
36,313,225
|
possibl multipl drug drug interact patient treat statin analysi data japanes advers drug event report jader databas verif anim experi advers drug event due drug drug interact prevent avoid concomit use causat drug therefor import understand drug combin caus drug drug interact although mani attempt identifi drug drug interact real world databas spontan report system perform littl known drug drug interact caus three drug polypharmaci ie multipl drug drug interact therefor attempt detect multipl drug drug interact use decis tree analysi use japanes advers drug event report jader databas japanes spontan report system first use decis tree analysi detect drug combin increas risk rhabdomyolysi case regist jader databas use six statin next risk three drug combin signific increas risk rhabdomyolysi valid vivo experi rat analysi identifi multipl drug drug interact signal pitavastatin report rate rhabdomyolysi pitavastatin jader databas increas combin allopurinol furthermor rate even higher combin valsartan addit necrosi leg muscl observ rat simultan treat three drug creatin kinas myoglobin level elev combin pitavastatin allopurinol valsartan treat caution multipl drug drug interact sinc multipl drug drug interact detect decis tree analysi increas risk verifi anim experi decis tree analysi consid effect method detect multipl drug drug interact
|
D019161;D032761;D064420;D012206
|
T121;T109;T062;T037;T046
|
36,313,224
|
molecular chang follow induct hepatocellular carcinoma diethylnitrosamin thioacetamid subsequ treatment dioscorea membranacea extract hepatocellular carcinoma hcc primari liver cancer common found adult previous show anticanc effect thai herbal plant extract dioscorea membranacea pierr dm hcc bear rat present studi examin propos mechan dm includ apoptosi antioxid activ moreov use rna sequenc rna seq analyz molecular pathway rat model hcc induc diethylnitrosamin den thioacetamid taa hcc bear rat treat mgkg dm week experiment control rat sacrif liver tissu collect rna seq data dentaa treat rat exhibit upregul hallmark pathway includ epitheli mesenchym transit inflammatori respons angiogenesi p dm extract expand bax protein posit pericentr zone tumor area decreas hepat malondialdehyd level impli decreas lipid peroxid liver howev dm treatment amelior molecular pathway induc dentaa treat liver find indic dm extract antioxid activ exert pro apoptot effect rat hccs vivo post translat level
|
D006528;D027742;D008113
|
T168;T191;T002
|
36,313,223
|
potenti transform growth factor beta inhibitor vascular endotheli growth factor inhibitor therapeut agent uterin leiomyoma background uterin leiomyoma common benign tumor women reproduct age caus infertil growth uterin leiomyoma mediat various steroid growth factor purpos studi evalu express various growth factor uterin leiomyoma addit compar effect exist medic specif growth factor inhibitor leiomyoma normal myometrium aim see potenti transform growth factor beta tgf inhibitor vascular endotheli growth factor vegf inhibitor therapeut drug uterin leiomyoma method vitro studi includ uterin leiomyoma sampl patient underw hysterectomi laparoscopi laparotomi seoul st mari hospit may march normal myometrium uterin leiomyoma tissu obtain patient express growth factor compar use immunohistochem stain primari cultur normal myometri leiomyoma cell cell viabil evalu follow treatment nm uliprist acet upa mifepriston h western blot analysi perform determin protein express growth factor cell viabil determin follow treatment tgf inhibitor ly vegf inhibitor axitinib h cultur normal myometrium leiomyoma cell result immunohistochem stain reveal signific higher intens tgf vegf leiomyoma tissu normal myometrium p mifepriston treatment decreas vegf express leiomyoma cell p accord cell count kit cck assay cell viabil decreas upa mifepriston tgf inhibitor vegf inhibitor treatment normal myometrium leiomyoma tissu effect tgf inhibitor signific differ normal myometrium leiomyoma tissu greater decreas cell surviv leiomyoma tissu p post hoc analysi show tgf vegf inhibitor greater inhibitori effect leiomyoma tissu compar upa conclus tgf vegf inhibitor signific decreas viabil uterin leiomyoma cell show stronger effect convent drug upa tgf inhibitor affect leiomyoma tissu normal uterus thus target local treatment rather system treatment consid
|
D014594;D007889
|
T191
|
36,313,222
|
inhibit adipos deriv stem cell invas keloid fibroblast background keloid repres dysregul cutan wound heal caus aberr fibroblast activ adipos deriv stem cell recogn promis treatment keloid howev molecular mechan fulli elucid object explicit demonstr relationship adipos deriv stem cell allevi keloid alter col col ctgf p hb method skin biopsi obtain keloid patient healthi volunt fibroblast isol sampl divid two group one co cultur adipos deriv stem cell grown independ compar wound heal rate fibroblast surviv rate apoptosi rate mrna express protein level col col ctgf p hb separ group result found signific differ normal fibroblast keloid fibroblast term wound heal rate surviv rate apoptosi rate baselin adipos deriv stem cell wound heal rate surviv rate normal fibroblast promot wherea keloid fibroblast reduc apoptosi rate normal fibroblast keloid fibroblast restrain restraint keloid fibroblast evid protein level col ctgf p hb lower keloid fibroblast co cultur adipos deriv stem cell normal fibroblast similar condit conclus adipos deriv stem cell strong suppress keloid fibroblast prolif invas behavior howev adipos deriv stem cell negat regul keloid fibroblast apoptosi adipos deriv stem cell potenti keloid therapi worth investig
|
D007627
|
T020
|
36,313,221
|
sar cov hiv differ yet alik immun respons cellular molecular level past half centuri human experienc two devast pandem hiv pandem recent pandem caus sar cov emerg zoonot pathogen interest sar cov rapid migrat world less two year much hiv almost year ago despit two rna virus differ mode transmiss well symptom generat recent evid suggest caus similar immun respons mini review compar molecular basi cd cell lymphopenia effect immun system induc sar cov hiv infect consid featur host immun respons share hiv could account lymphopenia immun effect observ covid inform provid herein may cast virus induc lymphopenia cytokin storm associ acut sar cov infect pathogenesi differ light research host immun respons also provid opportun identif novel therapeut target covid furthermor provid basic inform enabl compar framework consid overlap set immun respons caus hiv sar cov
|
D000086382;D015497;D008231
|
T047;T005;T067
|
36,313,180
|
downregul fxyd associ poor prognosi increas regulatori cell infiltr clear cell renal cell carcinoma fxyd gene code subunit na k atpas demonstr involv carcinogenesi recent howev specif role fxyd clear cell renal cell carcinoma ccrcc remain unknown current studi conduct investig express biolog function potenti immun relat mechan fxyd ccrcc materi method data tcga kirc icgc geo oncomin arrayexpress timer hpa dataset clinic sampl use determin valid express level prognost role potenti immun relat mechan ccrcc cell function assay perform investig biolog role fxyd vitro
|
D002292;D007680
|
T191
|
36,313,179
|
correl ferroptosi relat gene signatur immun landscap prognosi breast cancer breast cancer bc common diagnos cancer second lead caus cancer relat death women worldwid ferroptosi iron depend newli discov mode cell death induc lenaltinib play import role biolog behavior bc therefor prognost valu ferroptosi relat gene frgs bc warrant investig frg express profil clinic data download cancer genom atlas tcga databas gene express omnibus geo immun relat pathway found function analysi signific differ enrich score immun cell observ patient tcga brca includ train cohort six gene predict signatur construct least absolut shrinkag select oper cox regress model valid rest tcga brca geo cohort express six frgs verifi real time quantit polymeras chain reaction immunohistochemistri human protein atlas relaps metastasi like high risk group risk score independ predictor diseas free surviv collect ferroptosi relat risk model establish studi may serv effect tool predict prognosi bc
|
D001943;D000079403
|
T191;T043
|
36,313,178
|
effect lycium barbarum polysaccharid metabol dendrit cell vitro studi target dendrit cell dcs metabol relat pathway situ activ dcs becom new trend dc base immunotherapi studi shown lycium barbarum polysaccharid promot dcs function studi aim explor mechan lbp affect dcs function perspect metabolom mtt method use detect activ dc cell elisa kit method use detect content il il tnf supernat cell ultra perform liquid chromatographi quadrupol time flight mass spectrometri uplc q tofm use detect general chang dc cell metabol multidist covari bioinformat partial least squar discrimin analysi pls da use analyz differenti metabolit final metabol pathway analysi perform metaboanalyst v result show lbp signific inhibitori effect activ dc cell experiment dose gml lbp gml could signific stimul dc cell secret il tnf il moreov differenti metabolit could identifi includ betain hypoxanthin l carnitin methylthioadenosin orot acid sphingomyelin l glutamin metabolit involv metabol pathway top metabol pathway aspart metabol pyrimidin metabol phenylacet metabol methionin metabol fatti acid metabol result suggest effect lbp dcs function relat regul cell metabol
|
D032305
|
T002
|
36,313,052
|
spike base approxim backpropag algorithm brain inspir deep snn sonar target classif develop neuromorph comput attent paid brain inspir spike neural network snn ultralow energi consumpt high perform spatiotempor inform process due discontinu spike neuron activ function still difficult problem train brain inspir deep snn direct snn yet shown perform compar artifici neural network reason spike base approxim backpropag sabp algorithm general brain inspir snn framework propos paper combin two use end end direct train brain inspir deep snn experi show compar spike base method direct train snn classif accuraci method close best result mnist cifar dataset achiev best classif accuraci sonar imag target classif sitc small sampl dataset analysi show compar artifici neural network brain inspir snn great advantag comput complex energi consumpt sonar target classif
|
D016571;D000465
|
T170
|
36,312,898
|
fibroblast common serum respons signatur relat classif affect tumour microenviron predict prognosi bladder cancer abnorm oncogen signatur provid import clue regard cancer prognosi treatment analys variat oncogen signatur gene set normal tumour tissu cancer genom atlas tcga found csrlateup signatur upregul oncogen signatur gene set bladder cancer next develop common serum respons csr risk score crs model base fibroblast csr gene systemat analys correl gene crss surviv previous report molecular subtyp clinicopatholog featur cancer signal pathway chemotherapeut respons tumour microenviron use tcga valid cohort crs could predict malign phenotyp chemotherapeut efficaci immun invas diseas prognosi inflammatori signal pathway eg inflammatori respons tnfa signal via nfb ifn respons il stat signal mark upregul patient high crs notabl csr relat gene anln posit correl cd immun cell infiltr pd l express sensit pd l inhibitor could thus provid guidanc clinic immunotherapi studi highlight crucial role csr signatur bladder cancer provid crs model accur predict diseas prognosi chemotherapi immunotherapi respons
|
D059016;D001749
|
T070;T191
|
36,312,897
|
ros basic concept sourc cellular signal implic age pathway reactiv oxygen speci ros bioproduct cellular metabol rang molecul oxid properti known ros despit molecul impli negat age numer diseas key role cellular signal evid ros control sever biolog process inflamm prolifer cell death redox signal under cellular event one characterist new generat scientist aim defin role ros cellular environ control redox potenti includ balanc sourc ros antioxid system impli import target understand cell fate deriv redox signal review summar chemic redox balanc signal implic ros biolog age
|
D018384;D015398
|
T049;T044;T043
|
36,312,896
|
kynurenin pathway metabolit blood cerebrospin fluid associ human age kynurenin pathway implic age longev immun regul longitudin studi assess cerebrospin fluid csf lack investig tryptophan trp downstream kynurenin metabolit associ age chang time four cohort use comprehens target metabolom studi includ particip two cohort repeat metabolit measur mean age baselin year sd sd communiti dwell older adult age rang year csf donor mean age year sd first two cohort age associ kynurenin kyn quinolin acid qa kynurenin tryptophan ratio ktr invers trp consist find kyn qa ktr increas time wherea trp decreas similar qa ktr higher communiti dwell older adult age compar wherea trp lower kyn qa strong correl age csf compar serum increas subset particip repeat csf sampl n four year assess associ frailti mortal two cohort qa ktr strong associ mortal frailti studi provid robust evid chang tryptophan kynurenin metabol human age support link advers health outcom result suggest age activ inflamm stress driven kynurenin pathway system brain determin whether activ harm adapt identifi relat stronger age relat increas potenti neurotox end product qa brain
|
D007737;D000073496
|
T123;T184;T116;T033;T046
|
36,312,895
|
physic train reduc chronic airway inflamm mediat remodel asthma sever benefit aerob train asthmat patient demonstr howev effect system inflamm airway remodel mediat lung mechan unknown prospect studi includ intermitt mild asthma patient primari outcom evalu pro anti inflammatori pro antifibrot mediat exhal breath condens ebc blood perform beyond cell count blood induc sputum aerob train perform month time per week aerob train increas level anti inflammatori cytokin antifibrot mediat breath condens il ra p il p relaxin p klotho p respect similar plasma increas level il ra p il p relaxin p klotho p found contrari reduc level proinflammatori cytokin breath condens il p il p il p il p il p tnf p profibrot marker vegf p tslp p found similar plasma aerob train signific reduc level proinflammatori cytokin il p il p il p il p il p tnf p profibrot marker vegf p tslp p fraction exhal nitric oxid feno reduc intervent p regard inflammatori cell sputum reduct total cell p eosinophil p macrophag p well blood eosinophil p lymphocyt p aerob train posit modul chronic airway inflamm remodel mediat beyond improv system inflamm intermitt mild asthmat patient
|
D012065;D001249
|
T125;T121;T047;T116
|
36,312,894
|
combin individu herb mi jian chang pu formula exert synergist effect treatment ischem stroke rat mi jian chang pu formula mjcpf compos crocus sativus l acorus tatarinowii schott well known tcm treatment hemiplegia facial paralysi well languag dysfunct caus stroke ancient modern time use pharmacodynam pharmacokinet metabolom present studi discuss whether combin individu herb major activ compon mjcpf possess synergist neuroprotect effect ischem stroke adult male spragu dawley rat random equal divid group includ sham group n vehicl middl cerebr arteri occlus mcao model group vehicl posit group p mgkgday nimodipin crocin mgkgday asaron b mgkgday crocin asaron ab mgkgday c sativus mgkgday tatarinowii b mgkgday c sativus tatarinowii also name mjcpf ab mgkgday group drug oral administ rat day consecut day neurolog deficit score cerebr infarct volum bodi weight chang ttc ihc stain behavior evalu metabol profil pharmacokinet paramet determin mcao led sever brain damag includ larg infarct volum sever brain tissu injuri wors neurolog function compar sham rat treatment group show signific neuroprotect effect mcao rat furthermor pharmacodynam result demonstr mjcpf synergist effect evidenc small infarct volum regular arrang neuron cell improv neural function level inflammatori factor closer normal total differenti metabolit mcao sham group screen integr serum brain metabol restor vari degre treatment pca pls da analysi show level differenti metabolit treat mjcpf closer sham group individu herb singl compound alon ab combin pharmacokinet paramet verifi result mjcpf could synergist promot drug absorpt greater other integr pharmacodynam metabolom pharmacokinet approach reveal synergist effect mjcpf treatment power contribut understand scientif connot tmc formula
|
D002545;D000083242;D018696;D020521
|
T121;T047;T046;T169
|
36,312,858
|
breast cancer predict model base panel circul exosom mirna breast cancer bc serious threat women health exosom contain varieti biomolecul excel choic diseas diagnost marker whether could appli noninvas biomark bc diagnosi demand addit studi studi aim creat predict model reveal valu plasma exosom mirna exo mirna earli diagnosi bc first exosom isol plasma identifi nanoparticl track analysi nta transmiss electron microscop tem western blot mirna express plasma sampl bc patient normal control analyz high throughput sequenc mirna strong correl characterist select lasso logist regress built train set test set evalu lasso regress accuraci evalu perform differ model train set test set final go analysi kegg reactom pathway enrich analysi use understand biolog signific characterist mirna success separ exosom serum identifi nta tem western blot train set data matrix contain mirna obtain sequenc model construct strong correl mirna select lasso logist regress accuraci lasso regress train set test set respect built differ model evalu perform model train set test set result show auc valu lasso svm gbdt random forest model train set auc valu test set respect bioinformat analysi show signatur mirna signific enrich cancer relat pathway herp simplex virus infect tgf signal toll like receptor famili result studi suggest characterist mirna screen plasma exosom use group biomark predict model construct base set marker expect use earli diagnosi bc
|
D001943;D000074166;D055354;D035683
|
T026;T123;T191;T114
|
36,312,857
|
estim genet analysi use half diallel cross under kenaf hibiscus cannabinus l fibr yield tropic climat kenaf hibiscus cannabinus l natur fibr crop use varieti purpos various applic industri despit potenti fulli exploit low yield narrow genet base limit hybrid develop base background eight kenaf mutant one commerci cultivar select cross half diallel general specif combin abil gca sca get desir result done investig hybrid offspr parent line test field two environ diallel result base grif b method indic signific differ charact studi except gca top diamet plant height top diamet sca indic exist addit nonaddit gene action inherit trait amplitud gca variat much higher sca variat paramet except top diamet node number show addit gene preval likelihood genet advanc select condit hayman jink graphic studi demonstr partial domin control various fibr yield compon paramet plant height middl diamet stick weight fibr weight hand fibr yield major physic featur indic either domin overdomin gene action plant height base diamet core diamet middl diamet fresh stem weight stick weight strong posit correl fibr yield trait also higher proport addit effect moder narrow sens herit higher baker ratio indic success indirect select fibr yield parent p p p domin allel featur parent p p p recess allel hybrid p p p p p p p p p p p p p p p p p p outperform parent term heterot respons show lot genet potenti kenaf enhanc tropic climat
|
D031584
|
T002
|
36,312,856
|
displac pattern anterior posterior column fragment column acetabular fractur reconstruct base studi studi conduct examin displac characterist column acetabular fractur bcaf goal studi investig displac pattern anterior column ac posterior column pc fragment bcaf use virtual softwar
|
D050723;D006620;D016103
|
T037
|
36,312,855
|
hypophosphatemia coronavirus diseas covid complic consider systemat review coronavirus diseas covid various manifest differ bodi organ includ lung heart kidney central nervous system howev frequenc electrolyt abnorm especi hypophosphatemia still debat pandem main aim review evalu frequenc complic hypophosphatemia covid infect individu systemat literatur review perform web scienc scopus pubm embas cochran electron databas combin differ keyword till octob recruit relev publish record includ cross section case control studi well editori brief report assess hypophosphatemia among patient covid infect assess recruit record discard duplic record met inclus criteria three articl includ manual search literatur overal includ studi report subject male mean age rang year year hypophosphatemia preval report patient sever status covid higher preval low serum phosphat level moder infect review indic hypophosphatemia might categor complic clinic set covid pandem requir high clinic suspicion implement appropri diagnost therapeut intervent prevent life threaten outcom howev need elucid studi whether hypophosphatemia sever covid direct relat covid complic sever ill
|
D000086382;D017674
|
T047;T067
|
36,312,854
|
sandfli blood feed habit compet transmit ntepe virus recent discov member genus phlebovirus phlebovirus transmit sandfli among emerg public health threat novel phlebovirus name ntepe virus ntpv recent describ found infect human wide geograph area kenya howev entomolog risk factor virus potenti vector transmiss cycl remain poor defin studi assess abil colon sandfli phlebotomus duboscqi transmit ntpv determin bloodmeal host sourc field collect sandfli area ntpv found baringo counti kenya five day old laboratori rear p duboscqi oral challeng infecti dose ntpv pfuml incub day postinfect individu sandfli dissect abdomen leg salivari gland screen virus infect cell cultur virus expos sandfli develop non dissemin infect midgut evid virus dissemin transmiss leg salivari gland respect midgut infect rate decreas increas extrins incub period spearman correl blood fed specimen analyz polymeras chain reaction pcr sequenc region mitochondri rrna reveal almost exclus feed human repres sandfli sergentomyia schwetzi clydei antennata squamipleuri africana phlebotomus martini one specimen clydei fed cattl find suggest p duboscqi incompet laboratori vector ntpv high human feed rate divers sandfli speci increas likelihood human exposur pathogen associ sandfli assess suscept sergentomyia speci ntpv recommend given high human feed tendenc
|
D010691;D011576;D016856
|
T005;T204
|
36,312,853
|
antimicrobi antioxid activ apricot mimusopsi comersonii phenol rich extract applic edibl coat fresh cut veget preserv edibl coat sever advantag preserv food avoid water loss control microbi growth reduc need preserv ad direct product antimicrobi action obtain ad antimicrobi substanc includ phenol compound common found plant extract studi evalu phenol compound content antioxid antimicrobi activ pulp seed extract mimusopsi comersonii popular known brazil abrico besid phenol compound identifi quantifi pulp extract edibl coat incorpor pulp extract order evalu preserv minim process appl baroa potato foodborn bacteria enzymat brown also determin myricetin glucosid quercetin glucosid kaempferol glucosid identifi major flavonoid apricot pulp extract seed pulp extract inhibit test microorgan especi staphylococcus aureus salmonella typhimurium edibl coat ad phenol extract show vitro antimicrobi activ addit effect prevent enzymat brown minim process appl baroa potato day storag also effect reduc log cfug aerob mesophil day storag appl even though microbi inhibit baroa potato observ condit addit pulp phenol extract edibl coat prove altern preserv appl antibrown activ minim process baroa potato
|
D000080122;D000068219;D027845;D000890
|
T168;T121;T073;T002
|
36,312,841
|
could realli use occup therapi student percept learn coach coach evid base approach field relat novel within occup therapi ot yet wide taught ot program recent studi experienc occup therapist report coach ad valu practic ot student perspect miss literatur phenomenolog studi explor ot student n percept valu learn coach fieldwork three theme emerg induct qualit analysi coach requir mindset shift chang journey impact client occup therapi student perceiv coach requir differ way think reimagin role saw valu learn coach client outcom recogn potenti futur practic regardless set studi find suggest incorpor coach skill ot educ could benefici student enter profess
|
D009788;D000071252
|
T061;T065
|
36,312,840
|
link priorit occup perform patient undergo spastic correct upper limb surgeri intern classif function disabl health spastic general caus damag spinal cord area brain control movement pose signific limit occup task
|
D009788
|
T061
|
36,312,839
|
lentivirus mediat short hairpin rna interfer cenpk inhibit growth colorect cancer cell overexpress cullin colorect cancer crc one common malign tumor worldwid identif novel diagnost prognost biomark crc key research imper immunohistochem analysi reveal high express centromer protein k cenpk crc howev role cenpk progress crc well character
|
D015179;D003110
|
T191
|
36,312,838
|
mileston discoveri hepat c discoveri hepat c landmark public health brought opportun save million live diagnosi prevent cure diseas combin work three research alter h houghton rice c set basi diagnosi treatment prevent hepat c apart lay ground work new approach studi infect general develop new antivir agent stori transfus associ infect seri clinic studi demonstr exist infecti agent associ hepat follow identif later known hepat c virus hcv develop diagnost test preced full molecular identif demonstr causal effect final end develop discoveri new class therapeut drug direct act antivir use cure diseas probabl elimin problem work start dr alter h demonstr new virus respons major post transfus hepat follow houghton clone virus develop blood test identifi case carri virus final work rice c demonstr clone hcv produc appli molecular biolog techniqu could caus long stand infect caus diseas one observ human
|
D019698;D006526
|
T047
|
36,312,837
|
baishideng refer citat analysi databas announc first journal articl influenc index core journal list high qualiti academ journal gastroenterolog hepatolog three round rigor evalu core journal gastroenterolog hepatolog conduct refer citat analysi rca editori team baishideng publish group baishideng rca databas baishideng offici releas journal articl influenc index jaii core journal gastroenterolog hepatolog first time list core journal found https wwwreferencecitationanalysiscomsearchjourn among highest jaii lowest articl highlight top journal describ calcul method jaii evalu process inclus principl journal rca step underpin rca empir journal academ evalu servic digit platform address need author select reliabl journal submiss reader select high qualiti literatur read editor track journal citat perform rca core journal list serv use find journal tool interest parti welcom use journal list recommend peer
|
D005762;D010506
|
T170;T091;T073
|
36,312,836
|
massiv bleed gastric submucos arteri collater secondari splenic arteri thrombosi case report gastric submucos arteri collater gsac secondari splenic arteri occlus extraordinari rare potenti life threaten caus acut upper gastrointestin bleed report case massiv bleed gsac success treat mean multidisciplinari minim invas approach
|
D004621;D013927;D013158
|
T061;T047;T046
|
36,312,835
|
prognost perform index base lactic dehydrogenas transaminas patient liver steatosi covid metabol associ fatti liver diseas mafld associ complic mortal patient coronavirus diseas covid howev prognost score aim evalu risk sever diseas specif patient mafld despit high preval lactat dehydrogenas aspart aminotransferas alanin aminotransferas use marker liver damag therefor propos index base lactat dehydrogenas aspart aminotransferas alanin aminotransferas predict complic mortal patient mafld covid
|
D000086382;D005234;D065626
|
T047;T067
|
36,312,834
|
onlin calcul predict risk malign patient pancreat cystic neoplasm multicent retrospect studi effici practic method predict risk malign patient pancreat cystic neoplasm pcns lack
|
D010190
|
T191
|
36,312,833
|
insight hepat e virus epidemiolog croatia hepat e virus hev emerg virus global health concern seropreval rate differ great accord geograph region popul group
|
D016752;D016751
|
T005;T047
|
36,312,832
|
efficaci endoscop ultrasound evalu small gastrointestin stromal tumor gastrointestin stromal tumor gist diamet cm call small gist current endoscop ultrasound eus wide use regular follow method gist also provid preliminari basi judg malign potenti lesion howev studi accuraci eus assess malign potenti small gist
|
D046152;D013274
|
T191
|
36,312,831
|
immunotherapi base novel nanoparticl treatment gastrointestin cancer trend challeng gastrointestin cancer gic common cancer poor prognosi current surgeri main treatment gic howev high rate postop recurr lead low five year surviv rate recent year immunotherapi receiv much attent immunotherapi drug approv food drug administr fda immun checkpoint blockad icb drug great potenti cancer therapi nevertheless efficaci icb treatment great limit low immunogen immunosuppress microenviron gic therefor target immunotherapi expand icb increas tumor immunogen increas recruit matur immun cell reduc proport inhibitori immun cell like macrophag regulatori cell myeloid deriv suppressor cell moreov develop nanotechnolog varieti nanoparticl approv fda clinic therapi novel nanodrug deliveri system becom research focus anticanc therapi review summar recent advanc applic immunotherapi base nanoparticl gic gastric cancer hepatocellular carcinoma colorect cancer pancreat cancer describ exist challeng futur trend
|
D005770;D006528;D053758;D008113
|
T191;T073
|
36,312,830
|
applic artifici intellig system endoscop diagnosi superfici esophag squamous cell carcinoma upper gastrointestin endoscopi critic esophag squamous cell carcinoma escc detect howev endoscopist requir long term train avoid miss superfici lesion
|
D000077277;D004938
|
T191
|
36,312,597
|
bioinformat analysi common genet molecular trait associ portal hypertens pulmonari hypertens portal hypertens ph import caus pulmonari arteri hypertens pah mechan still unclear use genet data analysi explor share gene molecular mechan ph pah download ph pah data geo databas use weight gene coexpress network analysi method wgcna analyz coexpress modul idiopath noncirrhot portal hypertens incph cirrhot portal hypertens cph pulmonari hypertens respect enrich analysi perform common gene differenti gene express deg use verif target gene incph pah obtain string cytoscap softwar mirna target gene predict mirwalk mirdb targetscan biolog function analyz final use panglaodb predict express target gene cell wgcna gene modul signific relat pah cph incph identifi enrich function analysi show common pathway pah cph p signal pathway synthesi neutral lipid pah incph termin mainten regul granul toxin transport deg confirm result wgcna common mirna function pah cirrhosi enrich p signal pathway tgf signal pathway tnf signal pathway fatti acid metabol mirna mrnas network suggest hsa mir p regul mdm hsa mir p regul prdx target gene pah incph eifb hspa gnl rar utp hnrnpab hspb metap nar sacml target mirna function enrich show eifb hnrnpab hspb metap nar sacml hspa associ telomer inflamm panglaodb show target gene locat endotheli cell smooth muscl cell etc conclus mechan pulmonari hypertens induc portal hypertens may relat telomer dysfunct p overactiv lipid metabol intestin inflamm also involv process
|
D006976;D035683;D006975
|
T123;T047;T046;T114
|
36,312,596
|
analysi trend demograph distribut dental workforc kingdom saudi arabia dental profession play imper role healthcar system import distribut dental workforc across countri therefor studi aim analyz recent distribut dental workforc kingdom saudi arabia ksa determin current dentist popul ratio ksa cross section studi focus dental workforc work ksa complet data dentist work ksa differ profession rank obtain data stratifi gender profession rank saudi non saudi area work provinc ksa sector work public privat complet list dental univers obtain identifi increas number dental institut current moment addit dentist popul ratio also evalu base current inhabit ksa total dental surgeon total dental surgeon dental auxiliari regist differ specialti saudi citizen hold major post dentist dental auxiliari categori percentag male femal slight higher dentist dental auxiliari respect also indic dental personnel work privat sector dental auxiliari work public sector moreov highest number dental workforc identifi riyadh region among provinc base databas current dentist popul ratio conclus number dental profession ampl howev rural area lack specialist saudi dentist progress replac foreign dentist differ profession rank work ksa
|
D003815
|
T097
|
36,312,595
|
sfa net scale featur aggreg network retin vessel segment u net base network achiev competit perform retin vessel segment previous work focus use multilevel high level featur improv segment accuraci ignor import shallow level featur addit multipl upsampl convolut oper may destroy semant featur inform contain decod layer address problem propos scale featur aggreg network sfa net make full use multiscal high level featur inform shallow featur paper residu atrous spatial featur aggreg block rasf embed end encod learn multiscal inform furthermor attent featur modul aff propos enhanc effect fusion shallow high level featur addit design multi path featur fusion mpf block fuse high level featur differ decod layer aim learn relationship high level featur differ path allevi inform loss appli network three benchmark dataset drive stare chasedb compar current state art method experiment result demonstr propos sfa net perform effect indic network suitabl process complex medic imag
|
D016571;D007091
|
T170;T066
|
36,312,594
|
mobil health mhealth technolog earli detect diagnosi oral cancer scope review current scenario feasibl oral cancer one common type cancer dread consequ detect earli without much expens equip screen earli detect oral cancer use mobil health mhealth technolog report due avail extens network mobil phone across popul therefor aim explor exist literatur regard mhealth feasibl earli detect oral cancer materi method extens search conduct explor literatur feasibl mobil health earli oral cancer clinic studi report kappa agreement site dentist offsit health care workersdentist earli detect oral cancer includ review studi describ develop diagnost devic app develop qualit interview among practition train use mobil health also includ review broader perspect mhealth
|
D017216;D063731;D009062
|
T058;T170;T191
|
36,312,588
|
correl triglycerid glucos index coagul marker patient recent acut myocardi infarct metabol abnorm hypercoagul seem import predict role patient coronari arteri diseas cad triglycerid glucos tyg index emerg good marker metabol syndrom predict valu cardiovascular event overal haemostat potenti ohp reliabl global haemostat essay identifi hypercoagul cad patient aim studi therefor evalu possibl correl tyg index haemostat derang patient cad
|
D024821;D003324;D009203;D019851;D006490
|
T121;T047
|
36,312,587
|
associ polymorph nhej pathway gene hiv infect aid progress northern chines msm popul men sex men msm high risk hiv infect nonhomolog end join nhej pathway main way doubl strand dna break dsb repair higher eukaryot repair dsb time time cell cycl also indic nhej pathway associ hiv infect sinc dsb host genom dna occur process hiv integr aim present investig evalu associ singl nucleotid polymorph snps nhej pathway gene suscept hiv infect aid progress among msm resid northern china
|
D015497;D015658;D000163;D000072339
|
T005;T098;T047
|
36,312,586
|
databas mine detect cuproptosi relat prognost signatur relat regulatori axi breast cancer breast cancer frequent caus diseas burden relat cancer among women affect one women global one eight women high incom countri cuproptosi copper induc modal mitochondri cell death involv tumor prolifer metastasi
|
D001943;D062085;D035683
|
T123;T191;T114
|
36,312,451
|
bio tribocorros titanium dental implant toxicolog implic scope review bio tribocorros phenomenon combin essenti tribolog friction wear lubric corros microbiolog process late gain attent implant dentistri dental implant expos wear friction biofilm format corros oral environ may degrad upon exposur various microbi biochem electrochem factor oral caviti mechan movement implant compon produc friction wear facilit releas metal ion promot advers oro system reaction review describ bio tribocorros titanium ti dental implant oral caviti toxicolog implic origin research relat bio tribo tribocorros dental implant search electron databas like medlin pubm embas scopus web scienc studi includ review show factor like type ti oral biofilm acid ph fluorid micromov mastic promot bio tribocorros ti dental implant among various grade ti grade v ie tialv alloy suscept tribocorros oral pathogen like streptococcus mutan porphyromona gingivali produc acid lipopolysaccharid lps caus pit corros degrad tio low ph high fluorid concentr saliva hinder passiv film format promot metal corros releas metal ion promot inflammatori reaction bone destruct surround tissu result peri implant allergi hyper sensit reaction howev valid role bio tribocorros durabl ti dental implant ti toxic warrant clinic trial
|
D014025;D015921
|
T196;T074
|
36,312,318
|
road traffic nois obes risk incid type diabet cohort studi uk biobank object assess associ road traffic nois exposur type diabet td risk explor potenti moder effect obes method total particip uk biobank cohort open access cohort particip recruit unit kingdom uk includ studi cox proport hazard model fit assess associ road traffic nois exposur td result total particip diagnos td year median follow period everi db increas road traffic nois increas td risk hr ci besid signific posit interact observ obes road traffic nois p interact risk td associ road traffic nois td stronger overweight obes particip hr ci signific among lean one hr ci conclus studi observ longitudin associ road traffic nois exposur td risk stronger among overweight obes individu lean one
|
D009624;D003924
|
T047;T069
|
36,312,317
|
compar tobacco alcohol polici health system perspect case philippin singapor object provid compar analysi current tobacco alcohol control law polici philippin singapor method use public health law framework incorpor system approach use scorecard assess progress philippin singapor tobacco alcohol control accord sdg indic framework convent tobacco control global strategi reduc harm use alcohol collect data scientif literatur govern document result despit health system differ philippin singapor score high tobacco control countri receiv weak moder score alcohol control philippin singapor countri polici avenu reinforc restrict market improv corpor social respons program protect polici influenc industri reinforc tobacco cessat prevent measur alcohol harm conclus use health system base scorecard polici surveil alcohol tobacco control help set polici benchmark show gap opportun two countri identifi avenu strengthen current polici
|
D062789;D019460
|
T131;T092;T073;T109
|
36,312,316
|
covid vaccin attitud predictor among peopl live chronic health condit ibadan nigeria object assess vaccin attitud associ factor among peopl chronic health condit method cross section studi particip patient chronic medic condit data collect socio demograph covid relat characterist via open data kit softwar vaccin attitud examin vax scale adopt main outcom vaccin attitud status defin posit vax sum score median valu otherwis non posit data analys use chi squar multivari logist regress analys level signific result overal proport patient posit attitud toward covid vaccin uptak influenti factor toward posit attitud rate govern high handl pandem factor educ incom covid knowledg live room arrang p conclus less half peopl live chronic medic condit posit attitud toward covid vaccin attitud strong mediat confid govern govern could promot posit vaccin attitud improv clariti health instruct show govern transpar effect communic critic tool maintain public trust confid
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,312,315
|
burden diarrheal diseas associ factor among five children welkit town communiti base cross section studi object studi assess magnitud diarrhea associ risk factor among five children welkit town method use communiti base cross section studi design data collect period februari march parentsguardian five children studi particip structur questionnair observ checklist use collect data result week preval diarrhea among five year old children ci child mothercaregiv merchant aor ci compar housewif partial immun status aor ci dispos child stool garbag aor ci compar put toilet cover water storag materi aor ci presenc fli food prepar area aor ci associ increas odd diarrhea conclus preval diarrhea among five old children high associ occup motherscaregiv immun status children unhygien water storag condit non hygien household practic
|
D003967;D005191
|
T184;T098;T099;T062;T079;T102
|
36,311,955
|
measur issu antecolli antecolli defin involuntari forward flexion neck previous report measur neck flexion angl base line perpendicular ground led inflat neck flexion angl patient combin forward truncal flexion especi upper camptocormia
|
D010300;D013121;D009134;D014103
|
T033;T184;T047;T048
|
36,311,898
|
seven year follow ranzco cambodian ophthalmolog societi partnership cpd program royal australian new zealand colleg ophthalmologist partner cambodian ophthalmolog societi cos develop continu profession develop program cos use colleg colleg twin model program review seven year launch evidenceof function cpd program identifi reason may includ lack engag ophthalmologist lack cos resourc plan checklistfor intern cpd collabor discuss
|
D004502;D044466
|
T065;T098
|
36,311,897
|
call action persist lack transpar vaccin price practic covid pandem lack transpar vaccin price practic problem discuss long time tackl world health assembl adopt resolut improv transpar market medicin vaccin health product howev despit appal effect current pandem unequ global distribut vaccin resolut includ fundament pillar global health respons covid govern public health agenc provid public fund pharmaceut compani research develop new vaccin yet inform price strategi methodolog still inaccess furthermor compani profit public fund research develop secreci opac prevail pharmaceut industri affect low middl incom countri situat demand transpar account fair price pharmaceut product global health justic issu suggest independ global observatori account transpar pharmaceut global market creat help intern organ govern civil societi quest afford safe vaccin therapeut
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,311,896
|
manag unpredict recommend improv traine safeti global health away elect institut offer global health program safeti traine clinic rotat intern site paramount current guidelin global health elect recommend pre departur train safeti net resourc yet advic manag unanticip problem limit
|
D014943;D013337
|
T078;T091;T097
|
36,311,891
|
lincmir p regul cisplatin resist non small cell lung cancer via promot oxid stress non small cell lung cancer nsclc one common malign worldwid cisplatin base chemotherapi main treatment nsclc howev cisplatin resist nsclc cell major challeng nsclc treatment
|
D002289;D008175;D035683
|
T123;T191;T114
|
36,311,808
|
microgli exosom mir p induc brain injuri via promot hippocamp neuron apoptosi heatstrok brain injuri main caus poor prognosi heatstrok hs patient due heat stress induc neuron apoptosi howev new cross talk way among cell whether microgli exosom microrna mirna involv hs induc neuron apoptosi elucid
|
D001930;D018883;D035683
|
T123;T037;T114
|
36,311,807
|
porcin cgas sting signal induc autophagi inhibit sting downstream ifn apoptosi innat immun dna sens cgas sting signal pathway wide recogn induc interferon ifn subsequ antivir state addit ifn cgas sting pathway also elicit cell autonom immun event includ autophagi apoptosi howev downstream signal event dna sens pathway livestock well defin systemat analyz porcin sting psting induc ifn autophagi apoptosi reveal distinct dynam three sting downstream event establish ifn independ induct autophagi apoptosi investig regul autophagi psting induc ifn apoptosi follow tbk irf ifn activ sting induc atgatgl depend autophagi lir motif turn autophagi like promot psting degrad inhibit ifn product apoptosi thus restor cell homeostasi therefor studi shed light molecular mechan innat immun pig
|
D008565;D009713
|
T123;T126;T116;T192
|
36,311,806
|
effect exogen taurin supplement growth antioxid capac intestin immun resist streptococcus agalactia juvenil golden pompano trachinotus ovatus fed low fishmeal diet taurin various biolog function fish play essenti role growth resist oxid stress intestin immun evalu effect exogen taurin ad low fishmeal diet growth anti oxid stress intestin immun streptococcus agalactia resist juvenil golden pompano trachinotus ovatus studi show exogen taurin supplement group great enhanc weight gain rate specif growth rate sgr juvenil golden pompano signific upregul growth relat factor express brain liver well level growth relat paramet serum polynomi regress analysi use sgr estim optim dietari taurin level golden pompano moder exogen taurin also increas muscular thick villus length within intestin maintain intestin physic barrier stabil activ nrfkeap ho signal pathway increas intestin antioxid enzym gene express antioxid enzym activ serum upregul immunoglobulin complement level parallel declin reactiv oxygen speci ros level serum antioxid factor express also upregul intestin furthermor supplement suppress nf b signal intestin pro inflammatori cytokin gene express increas anti inflammatori cytokin gene express improv intestin immun final taurin supplement improv surviv rate golden pompano challeng agalactia overal find provid addit inform support ration use taurin healthi aquat anim farm
|
D000975;D010473
|
T123;T121;T039;T044;T013
|
36,311,805
|
long durat head tilt bed rest confirm relev neutrophil lymphocyt ratio suggest coupl platelet lymphocyt ratio monitor immun health astronaut identif safe easili determin inflight biomark monitor immun system astronaut mandatori ensur well success mission report evalu relev two biomark whose determin could easili implement spacecraft near futur use bedridden volunt ground base model micrograv spaceflight data confirm relev neutrophil lymphocyt ratio nlr suggest platelet lymphocyt ratio plr monitor assess long last immun diseas recommend coupl ratio biomark quantif cytokin viral load measur effici detect immun dysfunct determin countermeasur appli promot immun recoveri prevent develop diseas track respons treatment
|
D009504;D018480
|
T025;T097
|
36,311,804
|
neoadjuv sintilimab chemotherapi patient resect esophag squamous cell carcinoma prospect singl arm phase trial immunotherapi program cell death blockad enter rank advanc esophag cancer first line treatment howev littl known efficaci pd inhibitor neoadjuv therapi resect esophag squamous cell carcinoma escc aim evalu activ safeti neoadjuv sintilimab combin chemotherapi treatment resect thorac escc
|
D000077277;D004938
|
T191
|
36,311,802
|
tlr nf kb axi contribut monocyt inflammatori respons virul strain lichtheimia corymbifera causat agent invas mucormycosi invas mucormycosi im life threaten infect caus fungal order mucoral diagnosi often delay mortal rate rang due rapid progress individu suffer hematolog malign diabet mellitus organ transplant recent covid particular suscept infect mucoral given increas occurr diseas mucormycosi emerg one common fungal infect last year howev littl known host immun respons mucoral therefor character interact among l corymbifera one common causat agent im human monocyt special phagocyt play instrument role modul inflammatori respons sever pathogen fungi studi cover four relev aspect host pathogen interact recognit l corymbifera human monocyt ii intracellular fate l corymbifera iii inflammatori respons human monocyt common causat agent mucormycosi iv main activ pattern recognit receptor prrs inflammatori signal cascad respons l corymbifera demonstr l corymbifera exhibit resist intracellular kill hour germin inflict minim damag host cell nonetheless viabl fungal spore l corymbifera induc earli product pro inflammatori cytokin il late releas tnf il human monocyt moreov reveal il product predomin depend toll like receptor tlrs prime especi via tlr tnf secret via c type lectin receptor ctls il produc synergist activ tlrs ctls signal pathway lead activ nf kb transcript factor regul inflammatori respons also apoptot fate monocyt infect l corymbifera collect find provid new insight host pathogen interact may serv futur therapi enhanc host inflammatori respons l corymbifera
|
D009091;D000086382;D009090
|
T047;T004;T067
|
36,311,801
|
signific macrophag infiltr prognosi lung adenocarcinoma patient evalu scrna bulkrna analysi investig signific macrophag infiltr prognosi lung adenocarcinoma
|
D020733;D000077192;D008175
|
T123;T191;T114
|
36,311,800
|
increas preval clonal hematopoiesi indetermin potenti hospit patient covid clonal hematopoiesi indetermin potenti chip lead higher mortal carri cardiovascular risk alter inflamm three aspect harbor overlap clinic manifest covid studi aim identifi impact chip covid pathophysiolog hospit patient analyz chip addit diseas cours outcom evalu preval frequenc chip driver mutat signific higher preval expect base median age chip increas risk hospit cours diseas age independ impact outcom within group hospit patient especi younger patient year chip associ persist lymphopenia older patient year hand chip posit patient develop neutrophilia long run extent increas valu cardiac biomark caus chip independ age could elabor sole base studi conclus result indic increas suscept sever cours covid requir hospit associ chip second link differenti regul cellular immun respons pressur sar cov infect henc patient chip status bear potenti serv biomark risk stratif earli guid treatment covid patient
|
D000086382
|
T047;T067
|
36,311,799
|
human mhc class molecul hla mediat activ cd cell ifn product cell depend protect reactiv cerebr toxoplasma infect examin whether hla one common mhc class molecul human activ protect immun reactiv cerebr infect toxoplasma gondii hla transgen wild type wt mice infect treat sulfadiazin establish chronic infect brain one month discontinu sulfadiazin initi reactiv infect mrna level tachyzoit acut stage form specif sag number foci associ tachyzoit signific less brain hla transgen wt mice greater number ifn produc cd cell detect spleen infect transgen wt mice cd cell former produc mark greater amount ifn cell latter respons tachyzoit antigen vitro cd cell system transfer infect immunodefici nsg mice express hla cd cell hla transgen mice inhibit reactiv cerebr infect recipi effici wt cell furthermor inhibit reactiv infect cd cell transgen mice associ increas cerebr express ifn effector molecul tachyzoit recipi compar wt cd cell recipi thus human hla abl effect activ ifn product cd cell gondii tachyzoit confer potent protect reactiv cerebr infect parasit cd cell activ
|
D014122
|
T204
|
36,311,798
|
african swine fever virus infect activ inflammatori respons downregul anti inflammatori molecul cqtnf african swine fever asf danger pig diseas caus enorm econom loss global pig industri howev mechan asf virus asfv infect remain larg unclear henc studi investig host respons mechan asfv infect analyz differenti express protein dep serum sampl asfv infect uninfect pig use quantit proteom set p valu identifi dep compris upregul downregul protein belong various biolog process pathway base gene ontolog kyoto encyclopedia gene genom pathway enrich analys enrich pathway includ immun respons metabol inflamm signal pathway western blot analysi valid dep identifi use quantit proteom furthermor proteom data show cqtnf regul inflammatori signal pathway cqtnf knockdown led upregul pro inflammatori factor il il il thus inhibit asfv replic result indic cqtnf critic asfv infect conclus studi reveal molecular mechan under host asfv interact may contribut develop novel antivir strategi asfv infect futur
|
D000357;D000358
|
T047;T005
|
36,311,796
|
il bp product heterogen distribut crohn diseas crohn diseas cd form inflammatori bowel diseas ibd character impair epitheli barrier function dysregul mucos immun respons il bind protein il bp solubl inhibitor regul il bioactiv cytokin propos play protect role cd other shown il bp produc ibd inflam tissu henc suggest role cd work extend character il bp product distribut cd tissu appli enzym link immunosorb assay supernat obtain cultur endoscop biopsi patient revers transcript quantit polymeras chain reaction sort immun cell subset reveal il bp level higher inflam ileum colon observ cell intrins fashion popul mononuclear phagocyt eosinophil express il bp highest level comparison sourc cell suggest enrich intestin eosinophil could explain higher il bp level ileum inflam colon reveal presenc increas il ilbp ratio compar control strong correl il bp ccl identifi monocyt deriv dendrit cell modc cellular subtyp co express cytokin valid find use vitro cultur system also show retino acid induc secret il bp ccl modc final report higher il bp level activ smoker conclus work provid new inform relev therapeut strategi modul il bioactiv cd especi context diseas locat
|
D003424;D015212
|
T047
|
36,311,795
|
branch chain ketoacid deriv cancer cell modul macrophag polar metabol reprogram macrophag promin immun cell tumor microenviron educ pro tumor phenotyp tumor cell favor tumor growth metastasi mechan mediat mutualist relationship tumor cell macrophag remain poor character shown vitro differ human murin cancer cell line releas branch chain ketoacid bckas extracellular milieu influenc macrophag polar monocarboxyl transport mct depend manner found ketoisocapro kic keto methylvaler kmv induc pro tumor macrophag state wherea ketoisovaler kiv exert pro inflammatori effect macrophag process investig combin metabolomicsproteom platform uptak kmv kic fuel macrophag tricarboxyl acid tca cycl intermedi increas polyamin metabol proteom pathway analys reveal three bckas especi kmv exhibit diverg effect inflammatori signal pathway phagocytosi apoptosi redox balanc find uncov cancer deriv bckas novel determin macrophag polar potenti select exploit optim antitumor immun respons
|
D040901;D009369
|
T191;T091
|
36,311,794
|
ifn subtyp specif suscept hbv cours chronic infect chronic hepat b virus hbv infect continu major health problem worldwid remain hard cure therapi interferon ifn import method clinic treatment chronic hepat b ifn exhibit direct antivir effect well immunomodulatori activ induc sustain antivir respons part treat chronic hepat b patient numer ifn subtyp high sequenc ident exist character divers non redund biolog activ previous studi demonstr clinic approv ifn effect subtyp anti hbv treatment among ifn subtyp far littl known ifn subtyp express pattern earli hbv infect ifn subtyp specif suscept persist hbv infect well relat cellular mechan determin ifna subtyp mrna express acut chronic hbv infect use well establish hydrodynam inject hdi mous model reveal transient strong express panel ifna subtyp spleen hbv persist replic mice compar hdi control immunotherapi distinct ifn subtyp control chronic hbv infect ifn subtyp mediat antivir respons immun activ comprehens analyz aav hbv persist infect murin model murin ifn identifi effect subtyp suppress hbv replic analysi immun respons reveal strong immunomodulatori activ murin ifn splenic intrahepat nk cell activ persist hbv infect taken togeth data provid ifn subtyp specif differ antivir immunomodulatori effector respons strong express ifn subtyp spleen persist hbv infect mice knowledg support develop novel immunotherapeut strategi chronic hepat b infect
|
D019694;D006509
|
T047
|
36,311,793
|
tumor associ macrophag tumor progress role tradit chines medicin regul tam enhanc antitumor effect emphas import tumor associ macrophag tam tumor immun describ way extract tradit chines medicin tcm achiev tumor therapi modul macrophag
|
D008516;D009369
|
T060;T191;T091
|
36,311,792
|
novel inflamm relat lncrnas prognost signatur identifi linc promot prolifer migrat immun infiltr glioma studi total inflamm relat lncrnas high prognost valu identifi univari multivari cox regress analysi lasso analysi linc one lncrnas identifi posit associ type macrophag activ malign degre glioma fluoresc situ hybrid fish immunohistochem stain show linc high express high grade glioma type macrophag key transcript factor stat surfac marker cd also high express simultan linc high express glioma sensit anti pd anti ctla therapi linc also associ tumor prolifer tumor migrat valid edu cell coloni format cck transwel assay find reveal novel biomark predict glioma prognosi outlin relationship lncrnas inflamm glioma well possibl immun checkpoint target glioma
|
D062085;D005910
|
T123;T191;T114
|
36,311,791
|
type mrna covid vaccin immunomodulatori treatment influenc humor immunogen patient inflammatori rheumat diseas patient inflammatori rheumat diseas ird increas risk wors covid outcom identifi whether mrna vaccin differ immunogen examin effect immunomodulatori treatment may support covid vaccin strategi aim conduct long term model base comparison humor immunogen follow bntb mrna vaccin cohort ird patient patient swiss ird cohort scqm assent mrna covid vaccin recruit blood sampl baselin week post second vaccin dose test anti sar cov spike igg anti examin differ antibodi level depend vaccin treatment baselin adjust age diseas past sar cov infect ird patient provid elig sampl among monotherapi rituximab abatacept jaki tnfi highest odd reduc anti respons compar medic patient specif combin therapi show signific lower antibodi respons monotherapi irrespect diseas treatment past sar cov infect odd higher antibodi level week post second vaccin dose respect time higher mrna versus bntb p everi year age odd ratio higher peak humor immunogen follow mrna versus bntb increas p indic particular benefit elder patient result suggest ird patient two dose vaccin mrna versus bntb result higher anti level even elder patient
|
D000086382;D014765;D012216
|
T129;T047;T121;T067
|
36,311,790
|
immunovirotherapi role antibodi base therapeut combin oncolyt virus despit fact new drug target therapi approv cancer therapi past year major cancer type still remain challeng treat due tumor heterogen immun system evas complex interact tumor microenviron immun cell great major malign need multimod therapi unfortun tumor frequent develop treatment resist import varieti therapeut choic avail treatment neoplast diseas immunotherapi late shown clinic respons malign unfavor outcom oncolyt virus ov immunotherapi cancer treatment strategi employ natur occur genet modifi virus multipli preferenti within cancer cell ov abil induc oncolysi also activ cell immun system turn activ innat adapt anticanc respons despit fact ov translat clinic trial vec receiv fda approv melanoma use fight cancer face challeng includ target side effect immun system clearanc non specif uptak intratumor spread ov solid tumor although various strategi use overcom challeng strategi provid promis outcom monotherapi ov situat increas common use ration combin immunotherapi improv patient benefit develop aspect cancer immunotherapi strategi combin therapi propos improv anti tumor activ ov regard ov combin biotherapeut platform includ various form antibodi nanobodi chimer antigen receptor car cell dendrit cell reduc side effect ov enhanc efficaci articl review promis outcom ov cancer therapi challeng ov face solut combin biotherapeut agent
|
D050504;D050130;D008545
|
T061;T005;T191
|
36,311,789
|
comprehens character extracellular matrix relat gene paad identifi novel prognost panel relat clinic outcom immun microenviron silico analysi vivo vitro valid extracellular matrix ecm vital compon tumor microenviron interplay stromal tumor cell stimul capac cancer cell prolifer migrat invad undergo angiogenesi nevertheless crucial function ecm relat gene ecmg pancreat adenocarcinoma paad systemat evalu henc comprehens evalu ecmg requir pan cancer especi paad first pan cancer overview ecmg explor integr express profil prognost valu mutat inform methyl level pathway regul relationship seven ecmg ie lamb lama itgb itgb itga lamc cola identifi hub gene paad obvious regul paad consider link tumor stage well prognosi subsequ patient paad divid cluster premis ecmg express ecm score cluster subtyp best prognosi accompani lowest ecm score verifi ecm signific contribut pathophysiolog process paad signific differ observ oncogen tumor suppressor gene express immun microenviron chemotherapi sensit across three ecm subtyp appli varieti bioinformat method novel robust ecm associ mrna lncrna base prognost panel ecm app develop valid accur predict clinic outcom patient paad patient paad random categor train intern valid extern valid cohort meanwhil patient alloc high risk unfavor prognosi low risk favor prognosi popul premis express trait ecm relat mrnas lncrnas discrep tumor mutat burden immun microenviron might respons differ prognos across high risk low risk popul overal find identifi valid seven ecmg remark link onset progress paad ecm base molecular classif prognost panel aid prognost assess person intervent patient paad
|
D010190;D000230;D062085
|
T123;T191;T114
|
36,311,788
|
associ cervicovagin langerhan cell clearanc human papillomavirus human papillomavirus hpv clearanc import elimin cervic cancer contribut high morbid mortal women nevertheless remain larg unknown key player clear pre exist hpv infect hpv antigen detect import cervic antigen present cell langerhan cell lcs activ affect cervicovagin microbiota review first introduc persist hpv infect describ hpv suppress lcs activ includ limit antigen uptak present given specif transcript profil lcs cervic epithelium also discuss impact cervicovagin microbiota lcs activ well promis explor key microbi player activ lcs hpv specif cellular immun
|
D030361;D052685
|
T047;T005
|
36,311,787
|
epitheli cell alarmin cytokin frontlin mediat asthma inflammatori respons exposur airway epithelium extern stimuli allergen microb air pollut trigger releas alarmin cytokin il il thymic stromal lymphopoietin tslp il il tslp interact ligand il ra ilrl tslpr respect express hematopoiet non hematopoiet cell includ dendrit cell ilc cell endotheli cell fibroblast alarmin play key role drive type high lesser extent type low respons asthma addit studi three alarmin target allergen challeng mice show decreas chronic type driven diseas consequ ascertain mechan activ upstream mediat implic understand outcom target therapi design counteract activ allevi downstream type high low effector respons furthermor identifi factor shift balanc elicit type high eosinophil asthma type low neutrophil positiveneg asthma alarmin essenti support effort observ navig trial impli target tslp patient tezepelumab result reduc asthma exacerb improv lung function control diseas review discuss mechan surround secret il il tslp airway epithelium influenc allerg airway cascad also review detail alarmin receptorco receptor interact modul downstream allerg inflamm current strategi target alarmin efficaci inflammatori phenotyp discuss
|
D000067531;D001249
|
T123;T047;T116
|
36,311,786
|
develop valid nomogram predict model sever kidney diseas children henoch schnlein purpura prospect analysi two independ cohort forecast sever kidney diseas outcom hospit henoch schnlein purpura children studi aim develop valid nomogram forecast sever kidney diseas skd outcom hospit henoch schnlein purpura hsp children predict model built base primari cohort includ patient hsp diagnos januari decemb anoth cohort consist patient januari decemb recruit independ valid patient follow month developmenttrain valid cohort data gather multipl time point hsp month cover sever kidney diseas sever outcom hsp least absolut shrinkag select oper lasso regress model util decreas data dimens choos potenti relev featur includ socioeconom factor clinic featur treatment multivari cox proport hazard analysi employ establish novel nomogram perform nomogram assess aspect calibr discrimin clinic use nomogram compris serious skin rash digest tract purpura sever gastrointestin gi manifest recurr symptom renal involv predictor skd provid favor calibr discrimin train dataset c index ci furthermor demonstr receiv discrimin valid cohort c index ci use decis curv analysi nomogram proven clinic use nomogram independ predict skd hsp display favor discrimin calibr valu could conveni promot individu predict skd patient hsp
|
D011695;D007674
|
T047
|
36,311,785
|
microbiom metabolom analysi reveal alter composit metabol caecal microbiota metabolit dietari enteromorpha polysaccharid yeast glycoprotein chicken intestin microbiom respons ferment complex carbohydr orchestr immun system gut microbiota deriv metabolit previous studi report supplement enteromorpha polysaccharid ep yeast glycoprotein yg combin synergist improv antioxid activ serum lipid profil fatti acid metabol chicken howev mechan action polysaccharid remain elus present studi use integr rrna sequenc technolog untarget metabolom techniqu reveal mechan action epyg supplement broiler chicken fed basal diet diet supplement epyg mgkg ep mgkg yg result show epyg supplement alter overal structur caecal microbiota evidenc divers analysi besid epyg supplement chang microbiota composit alter communiti profil phylum genus level furthermor spearman correl analysi indic signific correl alter microbiota genera vs serum cytokin level microbiota genera vs volatil fatti acid product predict function analysi show epyg supplement signific enrich amino acid metabol nucleotid metabol glycan biosynthesi metabol energi metabol carbohydr metabol metabolom analysi confirm epyg supplement modul myriad caecal metabolit increas metabolit includ pyruv acid pyridoxin spermidin spermin dopamin decreas metabolit relat lipid metabol malon acid oleic acid docosahexaeno acid quantit enrich analysi result show glycolysisgluconeogenesi citric acid cycl tyrosin metabol glycin serin threonin metabol cystein methionin metabol import enrich pathway identifi enrich ratio wherea fatti acid biosynthesi biosynthesi unsatur fatti acid pathway suppress togeth rrna untarget metabolom result uncov epyg supplement modul intestin microbiota metabolit therebi influenc import metabol pathway suggest potenti feed addit
|
D064307;D044445
|
T001;T032;T002;T028
|
36,311,784
|
donor select kir alloreact associ superior surviv haploident transplant ptci continu increas use haploident donor transplant select donor becom increas import haploident donor select primarili base clinic characterist effect killer cell immunoglobulin like receptor kir outcom haploident hematopoiet stem cell transplant haplo hsct post transplant cyclophosphamid ptci remain inconclus present studi aim thorough evalu effect kir bind ligand assess various model addit patientdonor variabl clinic outcom haplo hsct cohort patient undergo first haplo hsct found higher count function inhibitori kir score cf ikir associ improv progress free surviv adjust hazard ratio hr p overal surviv os hr p none model predict surviv patient moreov use exploratori classif regress tree analysi found donor age year associ worst os rest cohort cytomegalovirus reactiv recipi donor year old higher cf ikir associ superior os year os rate hr p hr p hr p best better poor wors donor group respect result suggest kir alloreact assess cf ikir score help optim donor select haplo hsct
|
D046148;D019172
|
T061;T058
|
36,311,783
|
cxcr intrins drive matur function neutrophil mice neutrophil play major role protect infect also inflamm relat tumor microenviron howev cell extrins intrins cue drive function steadi state still fragmentari use cxcr knock mice evalu function chemokin receptor cxcr neutrophil physiolog show cxcr defici decreas percentag matur neutrophil spleen bone marrow bm also increas age cdl lo cxcr hi neutrophil spleen ko anim spleen cxcr neutrophil display reduc phagocyt abil wherea bm neutrophil show enhanc phagocyt abil compar wt neutrophil spleen cxcr neutrophil show reduc reactiv oxygen speci product f actin tubulin level moreov spleen cxcr neutrophil display alter signal reduc phosphoryl erk p mapk impair pik akt nf b tgf ifn pathway altogeth result suggest cxcr essenti neutrophil physiolog
|
D009504;D019869
|
T116;T126;T025
|
36,311,782
|
doubl side human leukocyt antigen g molecul type autoimmun hepat immunomodulatori effect hla g express role cancer human liver infect liver transplant well document far report address autoimmun liver diseas particular autoimmun hepat aih
|
D019693
|
T047
|
36,311,781
|
advanc immunotherapi glioblastoma multiform glioblastoma multiform gbm common aggress malign brain tumor central nervous system poor prognosi current standard care patient gbm involv surgic resect radiotherapi chemotherapi unfortun convent therapi result signific improv surviv outcom patient gbm therefor overal mortal rate remain high immunotherapi type cancer treatment help immun system fight cancer shown success differ type aggress cancer recent healthcar provid activ investig various immunotherapeut approach treat gbm review promis immunotherapi candid glioblastoma achiev encourag result clinic trial focus immun checkpoint inhibitor oncolyt virus nonrepl viral vector chimer antigen receptor car immunotherapi
|
D005909;D001932;D000076962
|
T129;T191;T116;T192
|
36,311,780
|
covid vaccin influenc subtyp cell pregnanc insuffici clinic data support safeti effect vaccin pregnanc post covid vaccin cell consid import compon immun system fight viral infect exhibit critic role throughout pregnanc period howev immunolog role cell pregnant women covid vaccin remain unclear therefor object studi investig alter frequenc express pattern activ receptor inhibitori receptor cell subset peripher blood sampl collect non pregnant vaccin women vaccin pregnant women unvaccin pregnant women find indic frequenc cd cell lower vaccin pregnant women unvaccin pregnant women signific differ found frequenc cd cell non pregnant vaccin women vaccin pregnant women addit signific differ frequenc cd v cell cd v cell cd v v cell v cellv cell ratio pregnant women without covid vaccin similar result found compar non pregnant pregnant women receiv covid vaccin howev signific differ fraction v v cell cd cell non pregnant vaccin women vaccin pregnant women frequenc nkgd cell v cell signific differ vaccin pregnant women compar unvaccin pregnant women non pregnant vaccin women percentag nkgd cell v cell lowest pregnant women covid vaccin furthermor regul nkp nkp found v v cell vaccin pregnant women respect vaccin regul pd express v cell v cell indic cell could respond covid vaccin display exhaust phenotyp follow activ conclus covid vaccin influenc subtyp cell pregnanc side effect might limit phenotyp chang v cell v cell promis predictor evalu clinic outcom covid vaccin
|
D016692;D000086382
|
T129;T116;T067;T192;T047
|
36,311,779
|
dysfunct macrophag lead diabet bone regener defici insuffici bone matrix format caus diabet chronic inflamm result bone nonunion perceiv worldwid epidem substanti socioeconom public health burden macrophag microenviron orchestr inflamm launch process bone remodel repair aberr activ macrophag drive drastic inflammatori respons diabet bone regener diabet mellitus prolifer resid macrophag bone microenviron limit enhanc myeloid differenti hematopoiet stem cell hscs lead increas constant monocyt recruit thus macrophag shift toward classic pro inflammatori phenotyp lead defici bone regener review systemat summar anomal origin macrophag diabet condit moreov evalu deficit pro regener macrophag diabet inflammatori microenviron final discuss latest develop strategi base target macrophag promot diabet bone regener briefli review aim provid basi modul biolog function macrophag acceler bone regener rescu diabet fractur heal futur
|
D008264;D003920
|
T047;T025
|
36,311,778
|
mucin degrad gut commens isol healthi faecal donor suppress intestin epitheli inflamm regul tight junction barrier function intestin epithelium surfac cover layer mucus harbor complex dynam popul bacteria term gut microbiota particular gut bacteria abil degrad mucin glycan nutrit sourc howev bacteri divers mucin degrad bacteria human gut microbiota role gut remain unclear studi character divers mucin degrad bacteria human gut microbiota establish cultiv base molecular profil method result show gut commens mucin degrad abil wide distribut gut microbiota abund previous thought addit mani previous uncharacter mucin degrad isol faecal sampl suggest mucin degrad gut commens underappreci gain better understand interact mucin degrad gut commens host effect commens intestin epitheli cell examin result reveal commens bacteroid spp parabacteroid spp akkermanisa muciniphila bifidobacteri dentium incit low level inflammatori respons il tnf suppress inflammatori respons induc e coli downregul nf b pathway presenc gut commens also show potenti enhanc epitheli tight junction tj barrier function regul mrna express tj protein gene zo occludin claudin e cadherin furthermor presenc commens bacteria p distasoni b thetaiotaomicron muciniphila complet part restor pro inflammatori cytokin il induc tj barrier disrupt conclus find indic mucin degrad gut commens wide distribut gut microbiota show anti inflammatori effect pathogen infect potenti modul epitheli barrier function
|
D019108;D009077
|
T123;T116;T030
|
36,311,777
|
distinct cd cell signatur ana posit young adult patient failur immun toler lead autoantibodi product result autoimmun diseas broad spectrum organ specif system disord immun toler mechan regul autoreact b cell yet lymphocyt escap promot autoantibodi product cd cell dysregul character decreas impair regulatori cell treg andor accumul memori effector cell th play crucial role pathogenesi diseas antinuclear antibodi ana test use first step diagnosi autoimmun disord although ana posit individu develop autoimmun diseas studi differ cell compart among healthi blood donor ana negat patient ana posit patient loss toler led autoimmun may improv understand toler mechan fail herein report ana posit patient exhibit distinct distribut cell subset signific reduc frequenc recent thymic emigr rte nave cell signific increas frequenc central memori cell th th cell modul within cell compart profound within year age rang moreov cd cell ana posit patient metabol activ determin signific increas mtorc mtorc signal compar ana negat patient healthi blood donor signific impair treg number pro inflammatori cytokin product observ result identifi uniqu cell signatur associ autoantibodi product absenc autoimmun diseas
|
D015496;D001327
|
T047;T025
|
36,311,776
|
olfactori receptor macrophag inflamm olfactori receptor or bind odor ligand largest famili g protein coupl receptor olfactori epithelium approxim member express human mice respect grow evid suggest extranas function or review express function macrophag special innat immun cell involv detect phagocytosi destruct cellular debri pathogen well initi inflammatori respons rna sequenc data mice suggest or may express macrophag macrophag express increas treatment toll like receptor ligand lipopolysaccharid also induc transcript inflammasom compon trigger human ora mous orthologu olfr cognat ligand octan induc inflammasom assembl secret il exacerb atherosclerosi octan posit correl blood lipid like low densiti lipoprotein cholesterol human anoth olfr activ lactat promot generat tumor associ macrophag dampen immun respons promot tumor progress olfactori receptor macrophag rich sourc untap opportun modul inflamm known mani or express macrophag promot modul inflamm progress area also requir deorphan or determin sourc ligand
|
D058847;D018035
|
T123;T116;T192
|
36,311,775
|
perturb cell receptor repertoir malaria infect children preliminari studi chang occur cell repertoir clinic malaria infect children remain unknown studi undertook first detail compar studi cell repertoir african children without clinic malaria test hypothesi clonotyp expans occur p falciparum infect contribut generat cell repertoir uniqu diseas state profil complementar determin region cdr tcr chain sequenc children plasmodium falciparum infect asymptomat uncompl sever malaria compar sequenc healthi children interest discov children symptomat malaria lower tcr divers frequenc share public tcr sequenc compar asymptomat children also tcr divers invers associ parasitemia furthermor cluster tcr sequenc base predict antigen specif identifi specif cluster mer amino acid motif overrepres asymptomat group compar diseas group investig find may help delin import antigen target vaccin therapeut develop result show cell repertoir children alter malaria suggest exposur p falciparum antigen disrupt adapt immun respons under featur diseas
|
D022801;D008288
|
T129;T047;T116
|
36,311,773
|
tnf induc metalloproteinas product associ neurolog manifest htlv infect individu htlv infect individu may develop neurolog inflammatori condit known htlv associ myelopathi hamtsp high product tnf observ patient exhibit higher provir load enhanc product proinflammatori cytokin lymphocyt prolifer comparison asymptomat htlv carrier present overact bladder oab htlv infect metalloproteinas mmps known degrad compon blood brain barrier favor migrat infect cell central nervous system moreov unbalanc product mmps inhibitor timp also associ tissu damag present work studi product mmp timp htlv infect individu without neurolog manifest hamtsp patient present higher concentr mmp peripher blood mononuclear cell pbmc cultur supernat well higher mmp timp ratio compar group studi mmp level posit correl provir load tnf oab htlv infect individu vitro neutral tnf signific decreas mmp level pbmc cultur supernat find indic associ mmp product proinflammatori state associ htlv infect well hamtsp
|
D015368;D015493
|
T005;T047
|
36,311,772
|
case report intervent therapi portal venous stenosi caus system vascul system vascul multisystem blood vessel disord howev portal venous involv extrem rare repres diagnost therapeut challeng due heterogen natur lack diagnost criteria limit effect therapi vascul report year old woman previous diagnos system vascul treat prednison present gastrointestin gi bleed admiss abdomin contrast enhanc comput tomographi ct three dimension reconstruct suggest atroph left hepat lobe enlarg spleen sever stenosi main portal vein liver biopsi show evid fibrosiscirrhosi prevent rebleed portal venous angioplasti balloon dilat collater varic embol perform gi hemorrhag resolv complet howev refractori ascit present month postop abdomin ct angiographi confirm recurr portal venous stenosi portal venous angioplasti stent implant perform treat portal hypertens pht relat complic intervent patient receiv anticoagul therapi continu immunosuppress therapi year follow patient experi onset gi bleed ascit therefor portal venous angioplasti stent placement could effect treatment prevent pht relat complic immunosuppress therapi fail
|
D006975;D056647
|
T033;T047
|
36,311,771
|
brief research report serum clara cell kda protein level increas patient hospit sever sar cov sepsi infect clara cell kda protein cc secretori protein primarili express epitheli cell lung previous studi show cc exert anti inflammatori immun modulatori properti acut chronic pulmonari diseas howev despit evid cc high biomark potenti evalu role infecti diseas yet limit
|
D003141;D000086382;D018805
|
T047;T046;T067
|
36,311,770
|
comprehens investig discov novel methyltransferas mettl one presum prognost gene kidney renal clear cell carcinoma potenti modul tumor immun microenviron recent increas number studi uncov aberr express methyltransferas like famili mettl play import role tumorigenesi mettl writer recent work discov mettl express high associ hazard ratio hr kidney renal clear cell carcinoma kirc compar tumor impli special function mettl kirc carcinogenesi function mechan mettl kirc remain most unknown
|
D002292;D007680
|
T191
|
36,311,769
|
alter transcript factor target associ differenti peripher blood mononuclear cell proport sarcoidosi sarcoidosi peripher lymphopenia anergi associ increas inflamm maladapt immun activ like promot develop chronic progress diseas howev molecular mechan lead reduc lymphocyt proport particular cd cell fulli elucid posit paradox peripher lymphopenia character dysregul transcriptom network associ cell function fate result alter transcript factor target activ
|
D012507;D008231
|
T047
|
36,311,768
|
il delet decreas rev erb protein influenc autophagi mitochondri marker skelet muscl acut exercis interleukin il act pro anti inflammatori cytokin intens correl exercis intens activ various pathway autophagi mitochondri unfold protein respons also il interconnect circadian clock relat inflamm suppress nuclear receptor subfamili group member nrd protein product rev erb sinc il link physic exercis modul metabol pathway autophagi mitochondri metabol investig relationship il rev erb adapt molecular pathway respons acut intens physic exercis skelet muscl present studi divid three experi first one wild type wt il knockout il ko mice divid three group basal time basal sacrif acut exercis hour hr post ex sacrif hour acut exercis hour hr post ex sacrif hour acut exercis second experi cc cell receiv il physiolog concentr rev erb agonist sr last experi wt mice receiv sr inject protocol gastrocnemius muscl cell collect revers transcript quantit polymeras chain reaction rtq pcr immunoblot techniqu summari downregul rev erb autophag flux mitochondri gene verifi il ko mice independ exercis wt il ko treat sr show upregul autophag gene cc cell receiv il modul nrd mrna level upregul express mitochondri gene howev treat sr il mitochondri gene express upregul cc cell autophag flux cc suggest particip rev erb protein il induc autophagi conclus present studi verifi adapt requir physic exercis increas mitochondri content improv autophagi machineri might intermedi interact il reverb
|
D015850;D056953
|
T129;T116;T192
|
36,311,767
|
factor influenc sar cov infect vaccin induc immun respons rheumatoid arthriti investig factor signific impact sever acut respiratori syndrom corona virus sar cov infect vaccin induc immun respons rheumatoid arthriti ra
|
D000086382;D014765;D001172
|
T129;T047;T121;T067
|
36,311,766
|
dna pkcs restrict zika virus spread requir effect antivir respons zika virus zikv singl strand rna mosquito born flavivirus signific public health impact zikv infect induc doubl strand dna break dsbs human neural progenitor cell may contribut sever neuron manifest newborn dna pk complex play critic role repair dsbs innat immun respons infect unknown howev whether dna pk regul zikv infect investig role dna pkcs catalyt subunit dna pk zikv infect demonstr dna pkcs restrict spread zikv infect human epitheli cell increas zikv replic spread dna pkcs defici cell relat notabl decreas transcript type iii interferon well ifit ifit il shown independ irf irf p canon transcript factor necessari activ type iii interferon promot mechan dna pkcs restrict zikv infect independ dsb thus data suggest non canon role dna pk zika virus infect act downstream ifn transcript factor effici antivir immun respons
|
D000071244;D000071243
|
T005;T047
|
36,311,765
|
hla associ pediatr autoimmun liver diseas current state futur research initi strongest genet associ autoimmun within chromosom p human leukocyt antigen hla complex resid review focus hla associ within pediatr autoimmun hepat autoimmun scleros cholang primari scleros cholang general consider overlap hla genotyp confer suscept pediatr autoimmun liver diseas howev uniqu hla associ protect hla genotyp exist numer area futur research initi pediatr autoimmun liver diseas hla associ clinic outcom autoantigen discoveri novel therapeut target hla autoantigen cell pathway highlight
|
D019693;D015209;D008107
|
T033;T047
|
36,311,764
|
integr analysi singl cell bulk rna sequenc identifi signatur base cell marker gene predict prognosi therapeut respons lung squamous cell carcinoma cancer immunotherapi increas success strategi treat patient advanc convent drug resist cancer cell prove play import role anti tumor tumor microenviron shape role explain lung squamous cell carcinoma lusc studi first perform comprehens analysi singl cell rna sequenc scrna seq data gene express omnibus geo databas identifi cell marker gene subsequ construct gene prognost signatur train cohort base cell marker gene cancer genom atlas tcga databas valid test cohort geo cohort area receiv oper characterist curv year train cohort test cohort geo cohort respect furthermor creat high reliabl nomogram facilit clinic applic gene set enrich analysi show immun relat pathway main enrich high risk group tumor immun microenviron indic high risk group exhibit higher immun score stromal score immun cell infiltr level moreov gene immun checkpoint human leukocyt antigen famili overexpress high risk group drug sensit reveal low risk group sensit chemotherapeut drug high risk group chemotherapeut drug short studi reveal novel prognost signatur base cell marker gene provid new target theoret support lusc patient
|
D008175;D002289;D002294
|
T191
|
36,311,763
|
sort nexin increas low densiti lipoprotein receptor relat protein membran express novel mechan acetylcholin receptor aggreg myasthenia gravi myasthenia gravi mg character autoimmun damag postsynapt membran neuromuscular junction nmj impair postsynapt acetylcholin receptor achr aggreg low densiti lipoprotein receptor relat protein lrp play import role achr aggreg endplat membran via agrin lrp muscl specif receptor tyrosin kinas musk cascad sort nexin snx regul degrad recycl various intern membran protein howev whether snx regul lrp remain unclear therefor examin regulatori effect snx lrp influenc achr aggreg mg select cc myotub induc lrp intern via stimul anti lrp antibodi confirm intracellular interact snx lrp snx knockdown overexpress confirm snx promot musk phosphoryl achr aggreg increas cell surfac lrp express establish experiment autoimmun mg eamg mous model identifi snx upregul improv fragment achr structur nmj allevi leg weak eamg mice thus result reveal snx may novel target futur mg therapi
|
D020720;D011950
|
T050;T116;T192
|
36,311,762
|
contriv multi epitop vaccin ensembl monkeypox diseas use immunoinformat approach current global outbreak monkeypox mpx diseas caus monkeypox virus mpxv result thousand infect case five death declar global health emerg intern concern world health organ given current challeng safeti exist vaccin vaccin prevent mpx infect andor onset symptom would signific advanc diseas manag context multi epitop base vaccin could well suit approach herein search public access databas virus pathogen databas analysi resourc mpxv immun epitop various antigen priorit group epitop cd cell four b cell epitop use comput aid techniqu base desir immunolog physicochem properti sequenc conserv criteria non human homolog three multi epitop vaccin construct mpxv fuse final epitop aid appropri linker adjuv beta defensin ribosom protein heparin bind hemagglutinin codon optim silico clone peta express vector ensur optim express construct escherichia coli system two three dimension structur construct vaccin predict refin optim bind mode construct immun receptor toll like receptor tlr tlr tlr explor molecular dock reveal high dock energi mpxv tlr kcalmol mpxv tlr kcalmol mpxv tlr kcalmol conform stabil energet favour bind vaccin tlr complex assess perform molecular dynam simul free energi calcul molecular mechanicsgener born surfac area method silico immun simul suggest innat adapt humor respons elicit upon administr potent multi epitop vaccin construct vaccin construct antigen non allergen non toxic solubl topograph expos possess favour physicochem characterist result may help experiment vaccinologist design potent mpx vaccin
|
D018984;D045908
|
T129;T047
|
36,311,761
|
common immun infiltr rheumatoid arthriti atherosclerosi screen central target via microarray data analysi although increas evid report increas risk atherosclerosi rheumatoid arthriti ra communal molecular mechan phenomenon still far fulli elucid henc articl aim explor pathogenesi ra complic
|
D001172;D050197
|
T047;T046
|
36,311,760
|
differenti immunolog effect silica nanoparticl peripher blood mononuclear cell silicosi patient control silicosi fibrot diseas caus inhal respir silica particl typic engulf alveolar macrophag subsequ induc releas inflammatori cytokin various anim experiment human studi focus model silicosi assess interact macrophag cell type silica particl still howev limit knowledg differenti respons upon silica exposur silicosi patient control focus studi respons peripher blood mononuclear cell pbmcs silica nanoparticl sinp ludox nm silicosi patient control prolif capac cd b cd cell evalu via carboxyfluorescein succinimidyl ester cfse assay activ status lymphocyt subset respons silica also evalu compar extent micro granuloma aggreg format cytokin secret profil group individu prolif capac cd cell elev silicot patient oppos control subset regulatori cell cd cd cd cd immunoglobulin igm igg also signific increas patient number size aggreg form higher sinp stimul patient compar control multivari analysi also elucid role key cytokin like interleukin il il interferon gamma ifn upregul sinp stimul pbmcs patient compar control ex vivo model thus potenti provid insight immunolog effect silica particl lymphocyt silicosi patient control
|
D012829;D053758
|
T047;T073
|
36,311,759
|
analysi heterogen hepatocellular carcinoma immun cell molecular risk model integr scrna seq bulk rna seq studi shown hepatocellular carcinoma hcc heterogen main caus lead failur treatment technolog singl cell sequenc scrna could accur reveal essenti characterist tumor genet
|
D006528;D008113
|
T191
|
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