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biomedical-topic-categorization-validation

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36.4M
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36,314,149
languag mechan reason possibl abil entertain reflect possibl crucial compon human reason howev origin reason whether languag base high debat contribut debat investig relat languag thought domain possibl development perspect investig focus disjunct syllog specif type possibl reason explor extens development literatur clear linguist correl seek link conceptu linguist represent review evid children reason disjunct syllog acquir logic modal languag sketch propos languag thought interact develop articl part theme issu think possibl mechan ontogeni function phylogeni
D007802;D011340
T171;T041
36,314,148
causal learn counterfactu reason pretend play cross cultur comparison peruvian mix low socioeconom status us children pretend play univers emerg earli childhood may support develop causal infer counterfactu reason howev amount time spent pretend valu adult place pretenc scaffold adult provid vari cultur socioeconom status ses middl class us preschool accuraci pretenc base causal reason task predict perform similar causal counterfactu task explor relationship cultur environ pretenc counterfactu reason low incom peruvian n low incom us n year old contrast find previous find age match mix ses us sampl n children learn novel causal relationship answer compar counterfactu pretenc base question relationship children respons counterfactu pretenc measur differ across popul peruvian lower incom us children provid fewer causal consist respons compar middl class us children nevertheless correl two measur emerg popul across cohort children also provid causal consist answer pretenc counterfactu find strengthen hypothesi causal pretend play relat causal counterfactu reason across cultur context also suggest role systemat environment differ articl part theme issu think possibl mechan ontogeni function phylogeni
D003431;D002657
T062;T039;T040
36,314,147
counterfactu think elicit emot chang young children adult often reason might happen chosen altern cours action past elicit counterfactu emot regret unclear whether young children emot similar impact counterfactu think past possibl studi year old children n open one two box conceal small larg prize respect children mean open either box wherea children mean open one box see prize obtain larger one obtain children signific like report negat chang emot non obtain prize straightforward counterfactu possibl show even young children experi counterfactu emot follow choic may ultim drive make better choic futur articl part theme issu think possibl mechan ontogeni function phylogeni
D004644
T041
36,314,146
young children share imagin possibl evid earli emerg human compet children abil reason junctur lead two differ destin emerg slowli converg evid conceptu watersh approxim year young children great ape misrepres junctur plan one expect outcom howev singular possibl oppos two mutual exclus possibl readili imagin share act upon year old analysi three domain support claim first year old respond appropri pretend spatial displac enact play partner second respond accur claim regard alleg unwit spatial displac also ask interlocutor possibl whereabout miss object absent person third ordinari convers appropri mark assert possibl rather actual summari although abil reason mutual inconsist possibl develop slowli preschool year abil imagin share inform possibl evid among year old noth compar observ great ape young children abil entertain share possibl diverg non human primat well potenti watersh year respect understand mutual exclus possibl articl part theme issu think possibl mechan ontogeni function phylogeni
D003142;D015186
T080;T015;T170;T054;T097
36,314,145
intertempor choic reflect valu comparison rather self control insight confid judgement intertempor decis make long assum measur self control promin theori treat choic smaller sooner reward fail attempt overrid immedi temptat view correct peopl confid intertempor decis success delay gratif two pre regist experi built replic adult particip n made monetari intertempor choic rate confid made right decis contrari assumpt self control account confid higher particip chose delay reward rather particip confid decis possibl reward apart time discount subject valu closer present larger magnitud demonstr metacognit insight particip confid decis better align separ valuat possibl reward decis made less confid prone chang mind suscept patienc enhanc manipul togeth result establish confid intertempor choic track uncertainti estim compar valu possibl reward decis unrel self control find challeng self control view instead cast intertempor choic form valu base decis make futur possibl articl part theme issu think possibl mechan ontogeni function phylogeni
D012201;D065786
T055;T041
36,314,144
import think futur cultur cumul cultur evolut think possibl play critic role choic human make throughout live despit influenc individu abil consid possibl cultur larg overlook propos abil reason futur possibl prospect cognit consequ cultur chang possibl facilit process cumul cultur evolut particular consid potenti futur cost benefit specif behaviour prospect cognit may lead flexibl use cultur behaviour speci limit plan abil may lead develop cultur promot behaviour futur benefit circumv limit examin idea compar perspect consid relationship human nonhuman assess futur possibl cultur capac invent new solut improv time given methodolog difficulti assess prospect cognit across speci focus plan data speci elucid role prospect cognit cultur help us understand variabl see cultur express inform ongo debat surround social learn mechan underli cultur articl part theme issu think possibl mechan ontogeni function phylogeni
D003468;D000067570;D015186
T068;T015;T041
36,314,143
would happen counterfactu hypothet causal judgement peopl make causal judgement paper show counterfactu simul necessari explain causal judgement event hypothet suffic two experi particip view video clip dynam interact billiard ball experi particip either made hypothet judgement whether ball b would go gate ball present scene counterfactu judgement whether ball b would gone gate ball present clip featur block front gate sometim move sometim stay put hypothet counterfactu judgement came apart comput model evalu hypothet counterfactu run noisi physic simul accur captur particip judgement experi particip judg whether ball caus ball b go gate result show tight fit counterfactu causal judgement wherea hypothet predict causal judgement discuss implic work theori causal studi develop counterfactu think children articl part theme issu think possibl mechan ontogeni function phylogeni
D013850;D007600
T078;T041
36,314,104
signific tumor reduct tradit chines medicin patient advanc prostat cancer case report prostat cancer pc common malign male genitourinari system patient advanc progress pc treatment strategi includ second line endocrin therapi chemotherapi immunotherapi therapeut techniqu either expens toxic patient tradit chines medicin tcm becom altern low cost low toxic applic shi pi san gui zhi fu ling wan pc never report report applic year old male patient diagnos pc undergo endocrin therapi origin chose chemotherapi experienc acut renal failur requir hemodialysi hospit felt weak opt chines herbal medicin treatment treatment shi pi san gui zhi fu ling wan patient tumor symptom signific reduc report feel refresh case indic tcm treatment uniqu advantag toler endocrin therapi chemotherapi consid patient undergo hemodialysi treatment use low molecular weight heparin lmwh prevent blood coagul take tcm whether lmwh synergist anticanc effect remain explor
D008516;D011471
T060;T191;T091
36,314,094
anaphylaxi updat anaphylaxi sever form acut system allerg reaction fatal absenc adequ treatment adrenalin propos review differ mechan under anaphylaxi well diagnost criteria manag regard guidelin world allergi organ wao
D000707
T047;T046
36,314,093
heal communic therapeut communic intern medicin caregiv patient communic central element therapeut relationship power placebo poor adapt communic harm effect adequ communic offer mani benefit patient caregiv therapeut communic tc set strategi inspir clinic hypnosi easi learn appli addit reinforc empathet attitud tc appear effect various clinic situat particular effect pain anxieti order better understand interest ct intern medicin conduct literatur review efficaci differ medic procedur
D003142;D006990
T061;T080;T170;T054;T097
36,314,092
thiamin simpli vitamin vitamin b also known thiamin essenti vitamin assur bodi function come exclus food vitamin b defici diagnos diseas less frequent suspect high incom countri howev risk factor like alcohol malnutrit common general popul thiamin defici lead three clinic entiti gayet wernick encephalopathi progress korsakoff encephalopathi wet beriberi dri form diseas associ high mortal heavi long term sequela rapid diagnosi enabl time treatment
D013832;D001602;D014899
T047
36,314,091
osmot demyelin syndrom over rapid correct hyponatremia hyponatremia frequent condit hospit patient associ signific morbid mortal associ rapid correct hyponatremia occurr osmot demyelin syndrom report osmot demyelin syndrom may present sever neurolog symptom includ rare case lock therefor rapid correct hyponatremia recommend presenc sever symptom case hyperton salin nacl mlkg minut recommend close plasma sodium monitor symptom improv increas sodium concentr exceed mmollh case without sever neurolog symptom use nacl solut avoid manag target under caus hyponatremia
D007010;D003711
T047;T046
36,314,090
intraven furosemid acut heart failur continu infus intermitt bolus loop diuret strong recommend current guidelin treatment acut heart failur intraven furosemid administ either continu infus intermitt bolus choic two rout alway obvious clinic practic understand differ mechan action well notion diuret resist help identifi patient may benefit either two rout articl aim discuss aspect pathophysiolog well summar current bodi evid random trial compar continu vs intermitt administr furosemid acut heart failur
D005665;D006333
T121;T047;T046;T109
36,314,089
sub segment pulmonari embol advent comput tomodensitometri led increas incid rate subsegment pulmonari embol clinic implic categori pulmonari embol remain unclear point expert question indic therapeut anticoagul purpos articl review exist literatur regard manag subsegment pulmonari embol propos pragmat approach regard indic therapeut anticoagul
D000925;D011655
T121;T047;T046
36,314,088
diabet pancreat cancer diabet indic pancreat cancer diabet pancreat cancer intric relationship risk factor develop case type diabet increas probabl develop pancreat cancer similar onset diabet often preced diagnosi pancreat cancer sinc hyperglycemia secondari tumor involv exocrin pancrea diabet consid pancreatogen current classif part entiti belong type c diabet pathophysiolog specif character high glycem variabl tendenc weight loss earli identif inaugur type c diabet would reduc diagnost delay could optim oncolog manag absenc specif marker challeng clinician indisput
D003924;D010190;D006943;D003920
T033;T047;T191
36,314,078
biofoul revers osmosi membran assess surfac enhanc raman spectroscopi microscop imag declin perform spiral wound revers osmosi swro membran frequent due biofoul studi focus qualit quantit diagnosi swro membran biofoul bacteri count differ surfac foul membran carri surfac enhanc raman spectroscopi ser perform highlight clog materi well natur ident topographi foul membran structur biofilm visual fluoresc microscopi fm scan electron microscopi sem result indic presenc bacteria differ swro membran area strong adher signific higher weak vari cfu howev ser map show differ foul level thick foul layer microscop imag reveal biotic abiot deposit data togeth allow better manag seawat desalin process
D057219;D018508
T070;T052;T057
36,314,067
novel transketolas inhibitor oroxylin suppress non oxid pentos phosphat pathway hepatocellular carcinoma tumour growth mice patient deriv organoid transketolas tkt key rate limit enzym non oxid branch pentos phosphat pathway ppp provid ribos requir de novo nucleotid biosynthesi promot develop hepatocellular carcinoma hcc pharmacolog inhibit tkt could imped hcc develop enhanc treatment efficaci howev safe effect tkt inhibitor approv
D006528;D008113
T191
36,314,066
identif mrap protein famili broad spectrum gpcr modul melanocortin receptor accessori protein mrap mrap well known endocrin regul traffick signal five melanocortin receptor mcr mcr observ mrap regul sever non melanocortin g protein coupl receptor gpcrs sporad report wherea endogen gpcr partner mrap protein famili larg unknown
D044101;D002352
T123;T116;T192
36,314,065
movement settlement behaviour cyprid balanus reticulatus surfac titanium alloy motion path balanus reticulatus cyprid similar titanium alloy surfac parallel grind surfac temporari attach durat settlement ratio cyprid influenc rough composit surfac correl posit surfac rough could also chang contact area number attach point cyprid similar pattern consequ rough composit surfac regul cyprid settlement temporari attach durat cross grind increas temporari attach durat drastic decreas settlement ratio compar parallel grind possibl due void drastic decreas contact area number attach point cyprid cross grind surfac respect cross grind therefor signific reduc cyprid settlement compar parallel grind
D001468
T204
36,314,051
reveal sens mechan fluoresc ph probe base bichromophor approach fluoresc sens play increas import role biolog biomedicin mani practic applic fluoresc probe respons prefer question fluoresc quenchingenhanc occur fundament high import applic design new fluoresc probe sens mechan aminorhodamin tmarh ph probe investig use femtosecond transient absorpt spectroscopi quantum chemic calcul show probe best understood use bichromophor model rather common model photoinduc electron transfer intramolecular charg transfer excit main absorpt band nm fast intern convers first excit state observ tmarh meanwhil new transient compon obtain tmarh excit direct weak absorb red tail nm confirm tmarh dark state theoret calcul show state intramolecular charg transfer state aminophenyl group rhodamin chromophor proton aminophenyl group yield htmarh transient intern convers process occur tmarh nm excit absent suggest charg transfer state becom high unfavor calcul spectral data confirm htmarh local transit rhodamin chromophor agreement bright state ph probe current work provid photophys insight sens mechan specif probe also show bichromophor model use may relev analyz probe design new one
D005456
T130
36,313,970
factor contribut measl outbreak hard reach rural villag xaisomboun provinc lao peopl democrat republ increas measl case report north western lao peopl democrat republ begin januari outbreak quick spread throughout countri follow identif two laboratori confirm case xaisomboun provinc conduct outbreak investig identifi factor contribut measl outbreak hard reach villag x
D008457
T047
36,313,964
quantit analysi contrast enhanc ultrasound use evalu angiogenesi patellar tendon heal rat investig efficaci contrast enhanc ultrasound ceus quantit evalu angiogenesi patellar tendon heal rat
D017847
T023
36,313,963
studi intellig tradit chines medicin fumig treat lumbar intervertebr disc herniat base medic big data mine improv tradit chines medicin fumig tcmf peopl studi lumbar intervertebr disc herniat lidh tcmf order clarifi thermodynam mechan tcmf lidh provid model refer individu diagnosi lower control system compil microprocessor upper control system compil comput technolog vb new system medic inform patient record databas upper control system clinic diagnosi treatment experi packag lower control system simul result clinic exampl show new control system tcmf better clinic efficaci lidh patient effect improv pain symptom lidh patient also econom safe
D007405
T047
36,313,955
tradit non tradit lipid profil bosnian patient probabl alzheim diseas vascular dementia conflict data exist tradit lipid profil patient alzheim diseas ad vascular dementia vd wherea scarc number studi evalu non tradit lipid profil patient ad vd studi shown ethnic background may affect lipid profil
D000544;D015140
T047;T048
36,313,954
lactic acidosi associ metformin patient diabet kidney diseas diabet mellitus metabolit disord paramet high blood sugar level manag diabet use drug metformin gold choic achiev therapeut effect rare caus side effect drug still debat view howev use excess dose patient kidney diseas contraind side effect lactic acidosi
D000140;D008687;D003928;D003924;D051436
T121;T047;T109
36,313,953
focal dermal hypoplasia osteopathia striata focal dermal hypoplasia genet diseas multipl system initi affect skin skeleton dental eye face development abnorm facial dysmorph focal dermal hypoplasia x link domin diseas affect ectoderm mesoderm endoderm featur de novo femal focal dermal hypoplasia induc mutat porcn gene
D005489;D017880
T019;T047
36,313,952
deep sternal wound infect open heart cardiac surgeri vacuum assist closur therapi singl center studi despit mani advanc prevent sternal wound infect especi deep one cardiac surgeri median sternotomi still present signific postop complic numer oper non oper procedur use treatment prolong hospit stay increas hospit cost treat postop complic
D054843;D006348
T061;T074
36,313,951
reliabl autom three dimension echocardiographi heartmodel ai versus echocardiographi simpson method evalu left ventricl volum eject fraction patient left ventricular dysfunct two dimension echocardiographi de simpson method frequent use imag modal assess left ventricular eject fraction lvef lvef import predictor morbid mortal wide rang patient clinic scenario despit import prognosi clinic decis make echocardiographi laboratori current determin ef primarili visual estim high experi depend sensit intra inter observ variabl suboptim accuraci repeat last decad dimension echocardiographi de becom increas implement clinic practic autom heartmodel ai track everi frame cardiac cycl use speckl technolog heartmodel ai fulli autom program simultan detect la lv endocardi surfac use adapt analyt algorithm consist knowledg base identif initi global shape orient follow patient specif adapt
D019560;D018487
T060;T046
36,313,950
kinet granuloma ifn ip wistar rat model infect mycobacterium tuberculosi improv access treatment critic control problem molecular diagnost test although avail feasibl develop countri avail test requir state art laboratori cheap one altern molecular diagnost use acut phase protein valu protein protein whose level increas decreas plasma respons injuri inflamm
D009169;D014376
T047;T007
36,313,949
iliopsoa hematoma abscess format complic anterior abdomin penetr injuri case report review literatur abdomin stab wound common clinic practic howev develop psoa muscl abscess follow injuri extrem rare moreov literatur surround psoa muscl hematoma format consequ penetr abdomin injuri scarc
D016659;D000007;D014951
T047;T037
36,313,948
legal regul health statist system reflect creation implement health polici kosovo health profession health institut document profession activ patient base health polici legal framework creat valuabl medic record health institut three level also scientif research purpos govern agenc design polici law strategi implement monitor polici base health statist form basi polici well health system nation level also region local level
D011634;D006291
T089;T091
36,313,947
laboratori diagnosi antimicrobi suscept genuin clinic spectrum streptococcus anginosus group experi univers hospit streptococcus anginosus group sag may unrecogn misidentifi clinic microbiolog laboratori result report consequ role genuin pathogen remain underestim
D034366;D013290
T047;T007
36,313,946
explor potenti poguntano extract diabet manag systemat review meta analysi poguntano picria fel terra merr tradit herb common use blood glucos lower agent indonesia howev effect herb yet establish
D003921;D003924
T047;T050
36,313,945
dimer predict factor axillari lymph node metastas oper breast cancer patient teach hospit universita sumatera utara axillari lymph node aln involv breast cancer bc consid signific factor determin diseas extent moment spread capac cancer cell may linear correl activ level turn alter coagul function common repres fibrin degrad biomark ie dimer although aln metastat status eventu percept physic examin diagnost modal addit marker estim lymph node extent consid pre oper session
D001943
T191
36,313,944
advanc case squamous cell carcinoma posterior later border tongu invad floor mouth squamous cell carcinoma scc common cancer oral caviti main affect patient age male femal ratio case oral scc link tobacco alcohol use
D014062;D002294;D009062
T191
36,313,943
associ platelet transfus mortal rate among preterm neonat eastern provinc saudi arabia platelet transfus main mode manag thrombocytopenia howev studi link frequent high threshold platelet transfus increment increas mortal rate
D017713;D013921
T061;T047
36,313,898
comprehens molecular analys slc famili base model stomach adenocarcinoma background solut carrier slc famili member crucial transport amino acid across membran amino acid indispens cancer immun cell howev clinic signific amino acid transport slc member stomach adenocarcinoma stad remain unclear studi aim develop slc famili base model predict prognosi respons stad patient immunotherapi method total tumor case obtain onlin databas train set n consist rna sequenc profil obtain cancer genom atlas tcga gene express omnibus geo use test set subsequ clinic characterist immun profil investig potenti immunotherapi respons predict valu model assess result base tcga cohort slc famili base model develop use multivari cox analysi tumor case stratifi high low risk group consid slc model high risk patient wors overal surviv os low risk patient consist result geo cohort comprehens analys reveal high risk group correl aggress relat pathway wherea low risk group better helper cell infiltr stronger immunotherapi respons compar high risk group low risk group present increas pd l tumor mutat burden conclus slc famili base model potenti predict prognosi immunotherapi outcom stad patient surviv patient low risk group great prolong patient may benefit immunotherapi
D013274;D000230
T191
36,313,818
molecular effect sglti empagliflozin autophagi pathway diabet mellitus type complic type diabet mellitus tdm especi hyperglycemia associ increas glucos cell toxic oxid stress lead irrevers damag kidney diabet nephropathi dn autophagi play key role degrad damag intracellular protein order maintain intracellular homeostasi cell integr disturb autophagi involv pathogenesi diabet nephropathi aim investig molecular effect sodium glucos transport inhibitor sglti express atg downstream collabor lc ii diabet nice model materi method use eight week old male mice twenti cbl wild type cbl twenti btbr obob dm twenti btbr obob treat empagliflozin dmempa fda approv sglti lysat murin renal cortex analyz western blot immunohistochemistri atg lcb fibronectin express analyz murin kidney tissu mice sacrif week begin experi
D000077203;D003924;D003928;D006943
T033;T121;T047;T109
36,313,817
adher dietari recommend associ factor among peopl type diabet cross section studi nepal intens lifestyl modif includ healthi diet chang diagnost status patient prediabet nondiabet type diabet improp eat habit increas insulin resist studi aim assess adher dietari recommend associ factor among peopl type diabet
D003924
T047
36,313,785
sex differ metabol healthi metabol unhealthi obes among chines children adolesc analyz sex differ preval obes phenotyp risk factor among children adolesc age year china
D012727;D000067329
T184;T032
36,313,784
sex specif regul il product human adipos tissu obes obes associ metabol complic display sexual dimorph impact cytokin previous show interleukin il upregul white adipos tissu wat obes women type diabet td whether pertain men unknown aim studi compar impact obes td wat il level men versus women
D016753;D003924
T129;T047;T116
36,313,783
dissect effect sphingolipid metabol gene progress microenviron osteosarcoma develop prognost signatur sphingolipid metabol sm fuel tumorigenesi malign progress osteosarcoma os lead unfavor prognosi elucid molecular mechan under sm osteosarcoma develop sm base prognost signatur could benefici clinic set studi includ frozen os sampl recogn vital sm relev gene develop os util univari cox regress least absolut shrinkag select oper lasso regress analysi conduct sm relev gene minim risk overfit prognost signatur generat util multivari cox regress analysi verifi valid cohort moreov cellular molecular mechan associ sm unfavor prognosi os patient wide studi result sm base prognost risk model establish accord critic prognost gene cbs glb hacd excel abil predict prognosi os patient auc train cohort auc valid cohort high risk os patient identifi base prognost signatur signific poor immun microenviron indic signific low immun score mean reduc infiltr immun cell includ nk cell logfc cdt cell logfc cytolyt activ logfc etc immunosuppress microenviron could due dysregul sm glycolipid nomogram construct integr sm base prognost signatur clinic parament facilit clinic applic nomogram could accur predict prognosi os invalid collect studi clarifi function sm develop os help develop tool risk stratif base sm relat gene applic clinic set result studi aid identifi high risk patient provid individu treatment
D012516;D001859
T191
36,313,782
effect dipeptidyl peptidas inhibitor postprandi glucagon level patient type diabet mellitus system review meta analysi hyperglucagonemia occur pathogenesi type diabet mellitus tdm meta analysi summar effect dpp inhibitor glucagon level patient tdm
D054873;D003924
T121;T047
36,313,781
valu radiom predict abnorm bone mass type diabet mellitus patient base ct imag paravertebr muscl investig valu ct imag featur paravertebr muscl predict abnorm bone mass patient type diabet mellitus
D014057;D003924
T060;T047
36,313,780
pattern tsh ft level across differ bmi rang larg cohort euthyroid patient obes multifold associ relat hypothalamo pituitari thyroid axi bodi weight potenti under mechan incomplet understood mild sever obes small proport individu obes far publish cohort studi provid littl insight metabol correl thyroid function obes
D020738;D013972
T125;T121;T116
36,313,779
investig anti diabet potenti molecular simul studi dihydropyrimidinon deriv attempt find new target amylas glucosidas treatment type diabet mellitus present studi aim determin anti diabet potenti synthes dihydropyrimidinon deriv vitro glucosidas amylas inhibitori activ perform molecular dock analysi ligand activ bind site target protein determin result reveal signific percent inhibit glucosidas compound benzyl hydroxyphenyl tetrahydro h pyrrolo pyrimidin dion compound activ compound show inhibit compar standard ascorb acid percent inhibit ic activ compound show gml molecular dock analysi reveal ligand bound activ bind site protein lowest bind energi kcalmol also signific similar standard kcalmol bind energi molecular dynam simul studi also reveal stabl bind ligand activ bind site protein low rmsd similar protein rmsd conclus studi reveal potenti new target glucosidas treat type diabet mellitus
D000520;D003924
T121;T047;T126;T116
36,313,778
weight gain type diabet sar cov pandem lockdown affect metabol control pediatr patient due sever acut respiratori syndrom coronavirus pandem govern mani countri decid implement lockdown includ school closur major lifestyl chang also appli peopl diabet aim paper analyz covid pandem relat restrict influenc metabol compens diabet pediatr popul
D003922;D000086382
T047;T067
36,313,777
model obes complex food system systemat review obes relat data deriv multipl complex system span media social econom food activ health record infrastructur sensor smartphon etc assist us understand relationship obes driver effici prevent treatment review literatur show grow adapt machin learn model recent year deal mechan intervent social influenc nutrit diet eat behavior physic activ built environ obes preval predict distribut healthcar cost relat outcom obes model design reflect time space individu level popul indic need macro level general popul model model consid interconnect multi system driver address obes preval intervent paper review exist comput model dataset use comput obes outcom design conceptu framework establish macro level general obes model
D009765;D004032
T168;T047
36,313,776
relationship triglycerid glucos index carotid plaqu high stroke risk popul southeast china popul base cross section survey cervic arteri atherosclerosi caa import risk factor stroke china triglycerid glucos tyg index simpl low cost marker ischem stroke whether tyg index predict cervic arteri atherosclerosi remain uncertain studi aim investig relationship tyg index cervic arteri atherosclerosi
D007333;D050197;D020521
T047;T046
36,313,775
vitamin adren gland myth realiti systemat review recent year vitamin becom protagonist mani studi cardiolog oncolog spotlight vitamin past consid import role phospho calcium metabol skelet disord today studi better thousand scenario facet open vitamin actual hormon respect authorit studi demonstr activ vitro vivo carcinogenesi inflamm autoimmun endocrinopathi role studi type type diabet mellitus hashimoto grave thyroid even adren gland diseas fact sever studi demonstr possibl correl vitamin addison diseas cush diseas hyperaldosteron adrenocort tumor moreov fascin hormon adren gland even seem deepli connect common genet pathway review aim analyz work tri studi possibl influenc vitamin adren diseas review analyz work tri studi possibl influenc vita min adren diseas
D003924;D006929
T047
36,313,774
identif cuproptosi relat lncrna prognost signatur osteosarcoma copper indispens miner element involv various metabol process function activ site mani metalloprotein copper dysregul associ cancer osteosarcoma os common primari bone malign invas metastasi howev causal cuproptosi os remain elus aim identifi cuproptosi relat long non code rnas lncrnas osteosarcomat prognosi immun microenviron respons immunotherapi
D062085;D012516
T123;T191;T114
36,313,773
blastocyst qualiti perinat outcom frozen thaw singl blastocyst transfer cycl investig effect blastocyst qualiti morpholog grade perinat outcom patient undergo frozen thaw singl blastocyst transfer cycl
D015925;D004624
T061;T059
36,313,772
integr machin learn electron health record data facilit detect prolactin level pharmacovigil signal olanzapin treat patient avail evid suggest elev serum prolactin prl level olanzapin olz treat patient schizophrenia howev machin learn ml base comprehens evalu influenc pathophysiolog pharmacolog factor prl level olz treat patient rare aim forecast prl level olz treat patient mine pharmacovigil inform prl relat advers event integr ml electron health record ehr data
D018967;D014150
T121;T039;T109
36,313,771
lack placent neurosteroid alter cortic develop femal somatosensori function placent endocrin function essenti fetal brain develop placent hormon includ neurosteroid allopregnanolon allo regul neurodevelopment process via posit alloster modul gaba receptor gaba r use mous model plko gene encod allo synthesi enzym specif delet trophoblast previous show placent allo insuffici alter cerebellar white matter develop lead male specif autist like behavior demonstr lack placent allo caus femal predomin alter cortic develop function placent allo insuffici disrupt cell prolifer primari somatosensori cortex sex link manner earli chang seen plko embryo sex persist primarili femal offspr birth adolesc plko femal show signific reduct pyramid neuron densiti well somatosensori behavior deficit compar plko male control litterm assess layer specif marker human postmortem cortic suggest preterm infant may also femal bias abnorm cortic layer specif compar term infant studi establish novel fundament link placent function sex link long term neurolog outcom emphas import grow field neuroplacentolog
D000081227
T123;T109
36,313,770
benign thyroid diseas risk breast cancer updat systemat review meta analysi correl benign thyroid diseas btd breast cancer bc long discuss howev definit relationship potenti mechan still disput current meta analysi aim perform comprehens assess relationship differ type benign thyroid diseas risk breast cancer furthermor assess whether benign thyroid diseas exert influenc aggress breast cancer
D013967;D001943;D013959;D006042;D006111
T047;T191
36,313,769
genet variant predict gestat diabet mellitus modul suscept nutrit intervent base mediterranean diet gestat diabet mellitus gdm entail complex under pathogenesi specif genet background effect environment factor studi examin link set singl nucleotid polymorph snps associ diabet develop gdm pregnant women differ ethnic evalu potenti modul clinic intervent base mediterranean diet
D016640;D038441
T061;T047
36,313,768
therapeut applic transcutan auricular vagus nerv stimul potenti applic neurodevelopment pediatr disord non invas transcutan auricular vagus nerv stimul tavn newli develop techniqu involv stimul cutan recept field form auricular branch vagus nerv outer ear result activ vagal connect central peripher nervous system increas evid indic maladapt neural plastic may underli patholog sever pediatr neurodevelopment psychiatr disord autism spectrum disord attent deficit hyperact disord disrupt behavior disord stress relat disord vagal stimul may therefor provid use intervent treat maladapt neural plastic current review summar current literatur primarili therapeut use adult discuss prospect appli tavn therapeut intervent specif pediatr neurodevelopment psychiatr disord furthermor also briefli discuss factor would help optim tavn protocol futur clinic applic conclud initi find tavn may promis altern treatment pediatr disord respond intervent
D055536;D000067877;D004561
T061;T048
36,313,767
associ liver enzym diabet mellitus risk differ obes subgroup popul base studi numer observ studi shown liver enzym correl diabet mellitus dm risk signific limit studi show whether differ obes subgroup present correl object evalu associ liver enzym dm risk differ obes subgroup base middl age chines popul
D008099;D003920
T023;T047
36,313,766
myocardi protect nitroso l cystein diabet cardiomyopathi mice diabet cardiomyopathi dcm sever complic diabet mellitus character aberr myocardi structur function primari caus heart failur death diabet patient endotheli dysfunct play essenti role diabet associ increas risk cardiovascular event role dcm unclear previous show nitroso l cystein csno endogen nitrosothiol deriv eno inhibit activ protein tyrosin phosphatas b ptpb critic negat modul insulin signal studi report csno treatment induc cellular insulin depend insulin independ glucos uptak addit csno activ insulin signal pathway promot glut membran transloc csno protect cardiomyocyt high glucos induc injuri amelior excess autophagi activ mitochondri impair oxid stress furthermor nebul csno improv cardiac function myocardi fibrosi diabet mice result suggest potenti site endotheli modul insulin sensit energi metabol develop dcm data studi help us understand mechan dcm also provid new therapeut option treatment
D058065;D003921;D026403
T123;T121;T050;T109;T047
36,313,765
prognost model cervic cancer base ferroptosi relat gene ferroptosi wide involv occurr develop various cancer specif mechan involv ferroptosi cervic cancer still unclear
D002583;D000079403;D035683
T123;T191;T114;T043
36,313,764
clinic perspect use gipglp receptor agonist tirzepatid treatment type diabet obes incretin base therapi glucagon like peptid receptor agonist glp ra alreadi establish treatment type diabet td develop novel dual tripl receptor agonist bind receptor glp also receptor glucos depend insulinotrop polypeptid gip andor glucagon intend address differ metabol pathway carbohydr lipid protein metabol simultan dual tripl receptor agonist act via differ receptor postreceptor pathway seem attract view potenti addit synergist effect treatment td obes recent first approv dual receptor agonist mark import step develop gipglp receptor agonist tirzepatid approv treatment td food drug administr fda usa week subcutan inject may receiv posit opinion european medicin agenc ema tirzepatid dose depend lead clinic signific reduct glycem paramet bodi weight shown stronger effect reduc paramet standard antidiabet therapi articl summar current clinic studi program respect outcom highlight potenti indic tirzepatid treatment obes potenti comorbid td
D000067757;D003924
T047;T192
36,313,763
contribut mitochondri gene variant diabet diabet kidney diseas mitochondri dna mtdna play import role pathogenesi diabet variant mtdna report diabet studi whole mtdna variant limit studi aim explor associ whole mtdna variant diabet diabet kidney diseas dkd
D003928;D003924;D028361
T047
36,313,762
interleukin metabol mice physiolog human diseas interleukin il classic member il superfamili cytokin il il precursor process inflammasomecaspas matur biolog activ form il bind specif receptor compos two chain il r il r trigger similar intracellular signal pathway il ultim lead activ nf b inflammatori process independ il like signal il also specif induc ifn product drive th immun respons circul il bind il bind protein il bp high affin let small fraction free il abl trigger receptor mediat signal contrast il famili member il produc constitut differ cell type suggest implic normal physiolog role il inflammatori process infecti diseas well describ recent experiment studi mice highlight action il signal control energi homeostasi pancreat islet immun liver integr nutrit stress time clinic observ implic il various metabol diseas includ obes type diabet nonalcohol fatti liver diseas nafld nonalcohol steatohepat nash present review summar discuss physiolog action il metabol potenti role pathophysiolog mechan lead common human metabol disord obes diabet nafldnash
D065626;D003922;D003924
T047
36,313,761
preoper red cell distribut width associ postop lymphovascular invas prostat cancer patient treat radic prostatectomi retrospect studi investig relationship baselin clinicopatholog laboratori variabl especi hematolog paramet lymphovascular invas lvi patient underw radic prostatectomi rp
D017430;D011471
T129;T191;T126;T116
36,313,760
differ choroid plexus volum microstructur associ bodi adipos choroid plexus cp cerebr structur locat ventricl function produc brain cerebrospin fluid csf transport protein immun cell alter cp structur function implic sever patholog includ age multipl sclerosi alzheim diseas stroke howev identif chang cp remain poor character obes one main risk factor neurodegener includ absenc frank central nervous system alter goal character associ obes measur bodi mass index bmi waist circumfer wc metric cp microstructur volum assess use advanc magnet reson imag mri methodolog cross section studi perform clinic unit nation institut age includ particip popul cognit unimpair individu span age rang year autom segment method freesurf use identifi cp structur analysi includ volumetr measur quantit relaxometri measur diffus tensor imag dti measur mean diffus md strong posit associ observ wc mri metric well cp volum compar group base establish cutoff point nation institut health wc modest differ md signific differ valu observ obes lean individu also found differ md obes overweight individu defin use bmi cutoff conjectur observ cp volum microstructur due obes induc inflamm diet like dysregul leptin bind transport find demonstr obes strong associ declin cp microstructur integr expect work lay foundat investig obes induc alter cp structur function
D050154;D002831
T023;T032
36,313,759
reproduct role vasopressinoxytocin neuropeptid famili teleost fish vertebr nonapeptid famili arginin vasopressin avp oxytocin oxt consid evolv singl vasopressin like peptid present invertebr term arginin vasotocin earli vertebr evolut unpreced genom sequenc avail recent allow new insight evolut nonapeptid especi receptor famili context whole genom duplic boni fish nonapeptid homologu avp term arginin vasotocin avp oxt famili peptid oxt origin term isotocin character reproduct role nonapeptid famili histor studi sever vertebr role teleost reproduct remain much less understood take advantag novel genom resourc associ technolog advanc genet modif fish model critic review current state knowledg regard role nonapeptid system teleost reproduct discuss sourc plastic conserv nonapeptid system context divers reproduct phenotyp observ teleost fish given dual role preoptic area poa synthes avp oxt neuromodul endocrineparacrin factor focus known role peptid reproduct behaviour regul hypothalam pituitari gonad axi emphasi place identif gonad nonapeptid system play critic role steroidogenesi gamet matur conclud highlight key research gap includ call translat studi link new mechanist understand nonapeptid regul physiolog context aquacultur conserv biolog ecotoxicolog
D010121;D014668
T125;T121;T116
36,313,758
dynam chang earli predict valu branch chain amino acid gestat diabet mellitus pregnanc branch chain amino acid bcaa close associ type diabet mellitus role gestat diabet mellitus gdm still controversi studi aim explor dynam chang bcaa pregnanc identifi potenti earli biomark gdm
D016640;D003924
T047
36,313,757
applic prospect trabecular bone score differenti thyroid cancer patient receiv thyrotropin suppress therapi thyroid stimul hormon tsh suppress therapi one common treatment patient differenti thyroid cancer dtc unfortun detriment effect bone health receiv increas attent may increas risk osteoporosi osteoporot fractur trabecular bone score tbs relat new gray scale textur measur paramet reflect bone microarchitectur bone strength shown independ predict fractur risk review first time scientif literatur use tbs dtc patient tsh suppress therapi aim analyz compar util tbs bone mass strength bmd manag skelet health predict fractur risk screen total seven relev public four postmenopaus femal patient three femal patient overal postmenopaus femal patient dtc lower tbs signific reduct tbs receiv tsh suppress therapi bmd appear chang signific addit tbs also found independ predictor osteoporot fractur risk postmenopaus women dtc receiv tsh suppress therapi howev due limit number studi studi popul evid suffici fulli demonstr advers effect tsh suppress therapi patient tbs bmd efficaci tbs subsequ larger case cohort studi need investig relationship applic tbs tsh suppress therapi term skelet health impair fractur risk dtc patient
D058866;D013964;D000230
T047;T191
36,313,756
camp signal cancer clinic diverg disord common central pathway camp signal cancer defin function signific somat mutat one element camp signal pathway unexpect wide rang cell origin clinic manifest potenti therapeut option mutat least camp signal pathway gene tshr gpr gnas pdeb pdea prkara prkaca prkacb creb identifi driver mutat human cancer although camp signal pathway cancer driven mutat imping singl signal pathway ultim tumor phenotyp reflect interact five critic variabl precis gene undergo mutat specif tumor type effect specif allel given gene mutat modifi gene mutat context tissu specif express various camp signal pathway element tumor stem cell precis biochem regul pathway compon tumor cell vari oncogen mechan reveal novel import target drug discoveri consider divers druggabl camp signal compon element gpcrs camp specif phosphodiesteras kinas appear prime drug candid element transcript factor protein protein interact current refractori robust drug develop effort refin precis driver mutat individu tumor essenti direct prioriti drug discoveri effort target mutat
D015398;D009369
T191;T044;T043
36,313,755
effect seawat freshwat challeng ghigf system salin toler blackchin tilapia sarotherodon melanotheron prolactin prl growth hormon gh well insulin like growth factor igf involv physiolog adapt fish vari salin igf also ascrib physiolog role develop growth reproduct immun regul howev main emphasi investig osmoregulatori respons endocrin liver deriv igf rout local regul within liver osmoregulatori organ studi focus impact salin alter ghigf system within neuroendocrin immun system particular salin toler speci blackchin tilapia sarotherodon melanotheron speci toler hypersalin salin variat confront sever climat chang saloum invers estuari investig bidirect effect increas salin follow decreas gene regul prl gh igf igf gh receptor tumor necrosi factor mix popul sexual matur month old blackchin tilapia adapt freshwat first expos seawat one week fresh water anoth week brain pituitari head kidney spleen excis h day exposur reveal differenti express pattern investig give us better understand role ghigf system within neuroendocrin immun organ impact bidirect salin challeng fish osmoregul non osmoregulatori organ notabl complex orchestr growth factor cytokin
D017210;D023681;D019382
T125;T121;T116;T013
36,313,754
risk preeclampsia gestat weight gain women vari prepregn bmi retrospect cohort studi despit import clinic signific limit data joint contribut prepregn bodi mass index bmi gestat weight gain gwg preeclampsia second lead caus matern mortal worldwid studi aim estim risk preeclampsia gwg among women vari prepregn bmi
D000078064;D011225
T033;T046
36,313,753
metabol syndrom common comorbid adult hypothalam dysfunct hypothalam dysfunct hd result various endocrin disord associ increas risk metabol comorbid studi aim analyz clinic characterist metabol abnorm adult hd various caus
D024821;D007006
T047
36,313,752
associ rheumatoid arthriti thyroid dysfunct meta analysi systemat review rheumatoid arthriti ra autoimmun disord multipl studi investig risk thyroid dysfunct patient ra reach conflict conclus systemat review aim determin whether patient ra higher risk thyroid dysfunct
D013959;D007037;D001172
T047
36,313,751
deciph core protein osteoporosi iron accumul proteom human bone iron accumul independ risk factor postmenopaus osteoporosi mechanist studi phenomenon still focus molecular genet research model anim osteoporosi iron accumul distinct endocrin diseas complic pathogenesi regul sever protein howev comprehens proteom wide analysi human bone lack use multiplex quantit tandem mass tag base proteom detect quantifi protein bone postmenopaus patient undergo hip replac compar non osteoporosi patient total differenti express protein identifi compris downregul protein upregul protein protein primarili affect oxidoreductas activ gtpase activ gtp bind neural nucleus develop main enrich neural angiogenesi energi relat pathway form complex regulatori network strong interconnect ultim identifi core protein gstp lamp copb rabb signific differenti express bone osteoporosi patient iron accumul valid chang protein level serum medic examin popul system analysi uncov molecular insight reveal under mechan clinic therapeut osteoporosi iron accumul
D040901;D010024
T047;T091
36,313,750
analysi factor influenc clinic outcom surgeri therapi patient moder risk thyroid papillari carcinoma general prognosi papillari thyroid cancer ptc favor howev moder risk involv warrant evalu henc investig clinic outcom patient moder risk ptc follow surgeri first therapi well relev factor influenc therapeut efficaci
D002291;D013964
T191
36,313,749
prolactin associ bone miner densiti subject type diabet mellitus prolactin prl exert action bone besid lactat reproduct studi aim investig whether prl relat bone miner densiti bmd type diabet mellitus tdm
D015519;D003924
T201;T081;T047
36,313,748
washout dna copi number analysi low coverag whole genom sequenc assess thyroid fnas papillari thyroid microcarcinoma ptmc defin papillari carcinoma measur mm current manag ptmc becom conserv howev high risk tumor featur reveal postop thyroid cancer braf mutat somat copi number variat cnv common genet event molecular test may contribut clinic decis make molecular risk stratif exampl predict lymph node ln metastasi build risk stratif model base molecular profil thyroid fine needl aspir fna washout dna wdna differenti diagnosi thyroid nodul
D016606;D013964
T191
36,313,746
identif differenti express gene mous paraspin muscl respons micrograv lower back pain lbp primari reason lead dyskinesia patient experienc peopl age increas evid reveal paraspin muscl psm degener psmd causat contributor lbp current research reveal fatti infiltr tissu fibrosi muscl atrophi characterist patholog alter psmd muscl atrophi associ abnorm elev oxid stress reactiv oxygen speci ros inflamm interest micrograv induc psmd lbp howev studi molecular mechan micrograv induct psmd strong limit studi identifi differenti express gene deg psm longissimus dorsi mice flown aboard bion biosatellit micrograv bioinformat analysi perform protein protein interact gene ontolog function kyoto encyclopedia gene genom pathway enrich analysi deg found ilra tnfaip myoa sesn lcn lrg pikr inflammatori gene fbox cdkna sesn mafb associ muscl atrophi cdkna sesn lcn net associ ros sesn net link oxid stress furthermor lcn fbxo cdkna pikr sesn net ilra myoa lrg pfkfb remark upregul wherea tnfaip mafb remark downregul psmd suggest might play signific role regul occurr develop psmd find provid theoret basi therapeut target treatment psmd
D014893
T070
36,313,745
effect obes status adolesc bone miner densiti satur effect cross section studi effect obes status bone miner densiti bmd adolesc whether satur effect still insuffici cross section studi adolesc age conduct investig
D015519;D001823
T201;T081;T032
36,313,744
canagliflozin mitig ferroptosi improv myocardi oxid stress mice diabet cardiomyopathi canagliflozin cana anti diabet drug belong sodium glucos cotransport inhibitor gain interest extra cardiovascular benefit ferroptosi new mode cell death promot occurr diabet cardiomyopathi dcm whether cana allevi dcm inhibit ferroptosi focus studi induc dcm model diabet cbl mice treat cana meanwhil order exclud hypoglycem effect high glucos model hc cell establish vivo studi observ cana could effect allevi damag cardiac function dcm mice includ increas lactat dehydrogenas ldh cardiac troponin ctni allevi myocardi fiber breakag inflamm collagen fiber deposit mitochondri structur disord evalu reactiv oxygen speci ros level dcfh da bodipi c vitro cana reduc ros lipid ros hc cell induc high glucos meanwhil jc fluorochrom assay show decreas mitochondri membran potenti mmp increas cana furthermor inhibitori effect cana myocardi oxid stress ferroptosi verifi vivo vitro protein carbonyl pco malondialdehyd mda superoxid dismutas sod catalas cat glutathion gsh key induc ferroptosi deposit total iron fe inhibit cana vivo vitro addit western blot result indic express ferritin heavi chain ftn h regul cystin glutam antiport xct regul cana dcm mice cell suggest cana inhibit ferroptosi balanc cardiac iron homeostasi promot system xc gshgpx axi dcm find underscor fact ferroptosi play import role develop progress dcm target ferroptosi may novel strategi prevent treatment conclus cana may exert cardiovascular benefit attenu ferroptosi
D000079403;D058065;D003920
T047;T043
36,313,743
testicular age male fertil beyond normal spermatogenesi sperm function crucial male fertil effect healthi testicular age testicular prematur age spermatogenesi sperm function spermatogenesi microenviron ignor compar younger men testi older men tend disturb spermatogen process sperm abnorm sperm dysfunct impair sertoli leydig cell ultim result male infertil various exogen endogen factor also contribut patholog testicular prematur age advers environment stressor gene mutat mechanist chromosom microdelet increas telomer length oxid stress accumul dna damag decreas repair abil alter epigenet modif mirna lncrna express abnorm associ impair male fertil due age recent year key molecul signal pathway regul testicular age prematur age identifi therebi provid new strategi diagnosi treatment review provid comprehens overview under mechan age spermatogenesi furthermor potenti rescu measur reproduct age discuss final inadequaci testicular age research futur direct research envisag aid diagnosi treatment testicular age prematur age
D013737;D019588
T023;T047
36,313,742
serum level hormon regul appetit patient cystic fibrosi singl center cross section studi cystic fibrosi cf common inherit genet determin diseas caus mutat gene cf transmembran conduct regul protein pulmonari failur lead caus death popul dysregul endocrin system creat signific disord includ malnutrit underweight cf relat diabet therefor object studi determin follow hormon serum patient cf ghrelin putat peptid yy pyy agouti signal protein asp alpha melanocyt stimul hormon msh knowledg serum level pyy asp msh yet assess cf purpos measur hormon level use enzym link immunosorb assay patient local cf care center well sex age match healthi control moreov estim correl test hormon paramet patient clinic status studi found sinific reduc serum level ghrelin asp patient cf p differ pyy msh level particip cf healthi subject furthermor differ hormon level femal male cf type gene mutat homozyg heterozyg f effect hormon level ghrelin negat correl age bodi mass index c reactiv protein pyy negat associ age patient hormon dysregul cf may contribut decreas appetit well mani disturb process therefor ghrelin appear play key role regul energi manag cf futur multicent multidisciplinari studi focus unequivoc understand role hormon cf
D054439;D003550
T125;T047;T116
36,313,741
spontan preterm birth involv multipl feto matern tissu organ system differ mechan pathway survivor preterm birth struggl multitud disabl due improp utero program various tissu organ system contribut adult onset diseas earli stage live therefor persist rate low birth weight birth weight gram well rate neonat matern morbid mortal need address activ research throughout year provid us multipl theori regard risk factor initi biomark clinic manifest spontan preterm birth fetal organ like placenta fetal membran matern tissu organ like decidua myometrium cervix shown uniqu respond specif exogen endogen risk factor uniqu contribut dynam chang molecular cellular level effect preterm labor pathway lead deliveri multipl intervent target differ tissu organ success test preclin trial reduc individu impact promot preterm birth howev preclin trial data effect translat develop biomark high risk individu earli diagnosi diseas becom evid examin current global rate preterm birth remain stagger high despit year research postul studi tissu organ silo major research conduct past year unlik address network interact various system lead synchron activ either term preterm labor deliveri address current limit review propos integr approach studi various tissu organ involv mainten normal pregnanc promot normal parturit import contribut toward preterm birth also stress need biolog model allow concomit observ analysi interact rather focus tissu organ silo
D047928;D007752
T046
36,313,740
neuroprotect effect melatonin glutam excitotox r cell mous retin ganglion cell glaucoma lead caus irrevers blind progress degener retin ganglion cell rgcs major characterist glaucoma even though control intraocular pressur could delay loss rgcs current clinic treatment protect direct overactiv n methyl aspart acid nmda receptor excess glutam glu among import mechan rgc death glaucoma progress melatonin mt indol neuroendocrin hormon main secret pineal gland studi aim investig therapeut effect mt glutam excitotox mous rgcs r cell glu induc r cell excitotox model nmda induc retin injuri model establish mt appli r cell vitreous caviti mice intravitr inject cell count kit assay propidium iodidehoechst perform evalu cell viabil reactiv oxygen speci glutathion synthesi assay use detect oxid stress state r cell retina immunofluoresc hematoxylin eosin stain appli assess rgc count retin structur flash visual evok potenti perform evalu visual function mice rna sequenc retina perform explor under mechan mt protect result found mt treatment could success protect r cell glu excitotox decreas reactiv oxygen speci also mt rescu rgcs nmda induc injuri protect visual function mice studi enrich indic mt treatment glaucoma provid practic research idea comprehens prevent treatment
D018696;D008550;D005901
T121;T109;T125;T047;T169
36,313,739
ovarian tissu cryopreserv transplant year experi bologna univers report year experi ovarian tissu cryopreserv otc ovarian tissu transplant ott bologna clinic center bologna itali
D059247;D009369
T061;T191
36,313,738
implement corneal confoc microscopi screen earli detect diabet neuropathi primari care alongsid retinopathi screen result feasibl studi screen diabet peripher neuropathi dpn essenti earli detect time intervent quantit assess small nerv fiber damag key earli diagnosi assess progress corneal confoc microscopi ccm non invas vivo diagnost techniqu provid accur surrog biomark small fiber neuropathi novel studi first time introduc ccm primari care screen tool dpn alongsid retinopathi screen assess level neuropathi novel cohort
D003929;D003924;D003930
T047
36,313,543
meta analysi breath life live systemat review scienc just admir cumul process stand shoulder giant yet scientif knowledg typic built patchwork research contribut without much coordin lack effici specif address clinic research recommend live systemat review research wast propos recommend meta analysi anytim live lead interim meta analysi provid statist methodolog meta analysi updat time reanalyz new observ retain type error guarante live need prespecifi look lead decis whether individu studi initi stop expand meta analysi lead sourc inform illustr method time event data show synthes data interim stage studi increas effici studi slow provid necessari number event complet meta analysi perform interim data analysi design requir inform number patient trial number trial eventu includ breath life live systemat review better simpler statist effici collabor communic
D012107
T062;T096;T170;T081;T169
36,313,541
microbiota dna isol rrna amplicon sequenc bioinformat analysi bacteri microbiom profil rodent fecal sampl fecal sampl frequent use character bacteri popul gastrointestin tract protocol provid profil gut bacteri popul use rodent fecal sampl describ optim procedur collect rodent fecal sampl isol genom dna rrna gene v region sequenc bioinformat analys protocol includ detail instruct exampl output ensur accur reproduc result data visual comprehens troubleshoot limit section address technic statist issu may aris profil microbiota complet detail use execut protocol pleas refer gubert et al
D019295;D064307
T001;T032;T091;T028
36,313,540
generat cell type specif proteom neurodevelop human cerebr organoid character cerebr organoid challeng due heterogen natur optim protocol streamlin generat fac purifi cell popul human cerebr organoid proteom analysi liquid chromatographi tandem mass spectrometri lc msms describ procedur enzymat dissoci organoid singl cell suspens generat cell type specif lysat peptid extract proteom analysi generaliz approach use studi tempor cell type specif protein dynam develop cerebr organoid complet detail use execut protocol pleas refer melliou et al
D020543;D040901
T123;T091;T116
36,313,539
protocol visual target specif drug bind mammalian tissu cellular resolut use tissu clear click chemistri provid protocol visual target specif drug bind mammalian tissu cellular resolut combin tissu clear click chemistri protocol allow fluoresc tag coval drug bind situ addit protocol compat molecular marker stain cell type identif complet detail use execut protocol pleas refer pang et al
D057930;D008322
T062;T070;T015
36,313,538
monitor fusion kinet viral target cell membran live cell use sar cov spike protein mediat membran fusion assay sever acut respiratori syndrom coronavirus sar cov spike protein mediat membran fusion virus target cell trigger viral entri latter describ sar cov spike protein mediat membran fusion assay use dual function split report protein quantit monitor fusion kinet viral target cell membran live cell approach appli various cell type potenti predict pathogen newli emerg variant complet detail use execut protocol pleas refer kimura et al b kimura et al c motozono et al saito et al saito et al b suzuki et al yamasoba et al
D064370;D000086382
T123;T047;T116;T067
36,313,537
kinet model platform predict efficaci sirna formul vitro vivo present comput model protocol accur predict chang vitro vivo gene express level respons applic various sirna formul describ use python base pipelin obtain crucial inform name maximum silenc level durat silenc toward design therapeut relev dose regimen protocol detail step run intern rate fit produc predict base experiment measur singl time point complet detail use execut protocol pleas refer roh et al
D020868
T045
36,313,536
protocol dissoci process analyz human lung tissu use singl cell rna seq report protocol obtain high qualiti singl cell transcriptom data human lung biospecimen acquir core needl biopsi fine needl aspir surgic resect pleural effus protocol reli upon brief mechan enzymat disrupt tissu enrich live cell fluoresc activ cell sort fac droplet base singl cell rna sequenc scrna seq protocol also detail procedur analyz scrna seq data complet detail use execut protocol pleas refer chan et al
D020869;D008168
T063;T023;T059
36,313,535
implement global approach effici simul molecular dynam agent base model biolog tissu protocol explain take agent base model abm molecular dynam set solv molecular dynam global approach use speed simul signific retain high level accuraci origin abm two option present implement global approach depend desir spatial variabl molecular concentr option coars grain molecular dynam space divid microenviron region uniform concentr complet detail use execut protocol pleas refer bergman et al
D056004;D000465
T066;T170;T044
36,313,534
effici rna rna protein co detect colonoid whole mount stain describ protocol visual rna oligo protein independ togeth use combin fluoresc situ hybrid fish immunofluoresc human colonoid expand previous publish research whole mount stain use preserv colonoid structur fix onto glass slide describ procedur effici plate fixat preserv colonoid workflow adapt organoid model tissu organ complet detail use execut protocol pleas refer et al
D012313;D009940
T024;T114
36,313,530
treatment thorac outlet syndrom complic assist cerebr embol protect devic report case stroke upper limb ischemia year old femal secondari right cervic rib retrograd thromboembol follow show complet patenc vessel thrombectomi intern carotid arteri stent follow transbrachi embolectomi perform cerebr protect devic cervic rib surgic remov prevent addit event
D016893;D013901;D057505
T047;T074;T020
36,313,479
biolog properti clinic signific lipoprotein associ phospholipas ischem stroke ischem stroke occur follow blockag blood suppli brain lead caus death worldwid main caus atherosclerosi diseas arteri character deposit plaqu fatti materi inner arteri wall multipl protein involv inflamm respons identifi diagnos biomark ischem stroke one lipoprotein associ phospholipas lp pla enzym hydrolyz circul oxid phospholipid generat proinflammatori lysophosphatidylcholin promot develop atherosclerosi last two decad number studi reveal concentr activ lp pla independ biomark ischem stroke us food drug administr fda approv two test determin lp pla mass activ predict stroke review summar biolog properti lp pla detect sensit limit lp pla measur clinic signific associ lp pla ischem stroke prospect therapeut inhibit lp pla intervent treatment
D000083242;D020521;D050197
T047;T046
36,313,402
short term efficaci high intens laser therapi allevi pain patient knee osteoarthr singl blind randomis control trial aim studi evalu efficaci high intens laser therapi hilt pain reduct patient knee osteoarthr oa
D020370;D053685
T061;T047;T074
36,313,231
determin low dose alteplas relationship lower intracerebr bleed risk acut ischem stroke background factor util intraven thrombolysi low dose alteplas mgkg whether low dose alteplas could reduc risk intracerebr bleed acut ischem stroke ai remain uncertain aim aim investig determin util intraven thrombolysi low dose alteplas assess associ low dose alteplas intracerebr bleed risk ai patient method includ ai patient receiv intraven thrombolysi use alteplas multicent retrospect observ studi investig associ baselin characterist util low dose alteplas identifi determin assess associ low dose alteplas risk symptomat intracrani hemorrhag sich use multivari logist regress model compar rate sich ich patient low dose group standard dose group use propens score match data result total ai patient includ studi mean age interquartil rang iqr women total patient treat low dose age adjust odd ratio confid interv ci p previous ischem stroke adjust ci p increas baselin systol blood pressur adjust ci p determin util low dose multivari logist regress analysi show low dose signific associ reduc risk sich adjust ci p propens score analysi show rate sich signific lower low dose group compar standard dose group vs p signific differ rate ich two group vs p conclus patient increas age higher baselin systol blood pressur previous ischem stroke higher odd receiv low dose alteplas low dose associ lower risk develop symptomat intracrani hemorrhag
D000083242;D002545;D020521
T047;T046
36,313,230
multipl prolifer signal pathway modul octacalcium phosphat osteoblast octacalcium phosphat ocp type bioactiv ceram may associ dentin tooth apatit especi bone generat promot wound heal fractur recent commerci bone graft product contain larg amount ocp materi releas ocp synthes larg quantiti report increas cell prolifer interact ocp cell signal pathway still unclear studi first demonstr ocp mediat cell signal pathway purifi ocp materi ocp regul p jnk c jun n termin kinas src akt protein kinas b signal pathway ocp crystal appear characterist ribbon shape vari sever ten micromet size x ray diffract pattern previous report studi two concentr ocp mgml mgml understand whether effect ocp cell signal pathway dose depend confirm ocp treatment affect cell prolifer alkalin phosphatas disrupt src phosphoryl chang total protein level p phosphoryl activ ocp treatment inhibit sb p total protein level chang ocp inhibit jnk phosphoryl signal wherea pd inhibit jnk phosphoryl without ocp interest akt total level decreas ocp treatment akt phosphoryl increas consider result demonstr ocp materi modul cell signal pathway increas cell prolifer
D051057;D002130
T121;T197;T126;T116