PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,311,758
|
serum angiotensin convert enzym potenti biomark sar cov infect vaccin efficaci various speci sar cov host cell receptor angiotensin convert enzym ace present serum may result virus entri subsequ proteolyt process membran receptor recent demonstr chang particular ace speci virus infect human either cleav fragment circul full length speci explor potenti serum ace biomark test sar cov infect vaccin efficaci virus suscept transgen k hace mice express human ace first serum sampl deriv k hace mice challeng lethal dose sar cov observ increas level cleav ace fragment day post challeng may repres subsequ proteolyt process virus entri elev level maintain death anim day post challeng circul full length ace form display sizabl peak day declin day post challeng notic immun two dose mva cov vaccin candid prevent ace cleav chang serum anim challeng lethal dose sar cov efficaci mva cov extend vaccin mice virus challeng find highlight ace could potenti serum biomark diseas progress vaccin sar cov
|
D000085962;D000086382
|
T047;T126;T116;T067
|
36,311,757
|
metabol requir th cell b cell regul defect health inflammatori diseas immun system protect infect cancer complex cellular network purpos immun cell requir well develop mechan energi generat howev immun system also caus diseas defect regul result emerg autoreact lymphocyt recent studi provid insight differenti pattern immun cell respons associ select metabol pathway review examin chang metabol requir th cell b cell differ stage develop activ cell provid protect also mediat diseas product autoantibodi product proinflammatori mediat health b cell produc antibodi cytokin present antigen cell mount specif immun th cell hand provid protect extra cellular pathogen mucos surfac also drive chronic inflamm latter cell also promot differenti b cell plasma cell produc autoantibodi metabol regul checkpoint differ stage develop ensur self reactiv b cell clone needless product interleukin il limit metabol regul two cell type similar eg util hypoxia induc factor hif low oxygen tension prevent autoimmun regul inflamm also clear differ th cell vulner lack certain amino acid b cell unlik th cell also depend mechanist target rapamycin mtorc function signific knowledg recent gain particular th cell metabol regul cell influenc epigenom metabol dysregul th cell b cell lead chronic inflamm diseas associ alter genom addit caus dysregul metabol therebi result epigenet alter cell recent studi highlight patholog result cooper two cell type far address key metabol alter set knowledg impact metabol dysfunct chronic inflamm patholog reveal novel therapeut target treat diseas
|
D058504;D015551
|
T046;T025
|
36,311,756
|
bovin delta papillomavirus e oncoprotein negat regul cgas sting signal pathway cattl spontan model viral diseas persist infect tumorigenesi papillomavirus pvs requir viral manipul various cellular process includ involv innat immun respons cyclic guanosin monophosph adenosin monophosph synthas stimul interferon gene cgas sting pathway emerg essenti innat immun sens system recogn dna trigger potent antivir effector respons studi found bovin pv bpv e protein major oncoprotein bovin delta pvs interact sting cgas spontan bpv infect neoplast urotheli cell cattl real time rt pcr reveal signific reduct cgas sting transcript e express cell furthermor western blot wb analysi fail detect variat express interferon induc protein ifi upstream effector sting pathway ternari complex compos estingifi also observ co immunoprecipit studi show sting interact protein network compos total phosphoryl tank bind kinas tbk total phosphoryl interferon regulatori factor irf irf ikk ikk ikk elk mekk tak rt qpcr reveal signific reduct tbk mrna level bpv infect cell wb analysi reveal signific reduc express level ptbk essenti activ phosphoryl irf prerequisit latter enter nucleus activ type ifn gene wb also reveal signific express ikk ikk ikk overexpress irf elk mekk takin bpv posit urotheli cell compar uninfect healthi cell phosphoryl p p p signific reduc nuclear cytosol compart bpv infect cell compar uninfect urotheli cell result suggest innat immun signal pathway mediat cgas sting impair cell infect bpv therefor effect immun respons elicit virus facilit persist viral infect subsequ tumorigenesi
|
D051550;D014777
|
T123;T047;T126;T116
|
36,311,755
|
therapeut effect fc gamma riv inhibit mediat select block immun complex induc neutrophil activ epidermolysi bullosa acquisita epidermolysi bullosa acquisita eba subepiderm autoimmun bullous diseas caus autoantibodi target type vii collagen col character inflamm subepiderm blister main immun complex ic mediat activ neutrophil experiment eba bind neutrophil ic skin induct clinic diseas depend express fc gamma receptor fcr iv activ fcr mediat neutrophil extravas activ use multiphoton imag obtain insight mechanist contribut fcriv pathogenesi eba first demonstr block fcriv function complet protect lysm egfp mice induct antibodi transfer induc eba visual interact anti col igg neutrophil vivo fluoresc label anti col igg inject lysm egfp mice multiphoton microscopi sequenti perform period day time point observ signific higher extravas neutrophil skin mice treat anti fcriv antibodi compar control howev percentag detect neutrophil local target antigen along dermal epiderm junction compar group addit reactiv oxygen releas migrat vitro assay data demonstr fcriv antibodi treatment inhibit activ migrat neutrophil find underscor import advanc vivo imag techniqu understand complex ic mediat neutrophil depend inflamm indic therapeut util fcriv blockad achiev impair ic mediat neutrophil activ
|
D016107
|
T047
|
36,311,754
|
immun regul emerg role noncod rnas mycobacterium tuberculosi infect tuberculosi caus mycobacterium tuberculosi engend oner burden public hygien congenit adapt immun human bodi act robust defens pathogen howev coevolut human microb gain multipl line mechan circumv immun respons sustain intracellular persist long term surviv insid host moreov emerg evid reveal stealthi bacterium alter express demic noncod rnas ncrnas lead dysregul biolog process subsequ may rational behind pathogenesi tuberculosi meanwhil differenti accumul clinic sampl endow capac indic time tuberculosi suffer articl review nearest insight impact ncrnas mycobacterium tuberculosi infect realiz via immun respons modul potenti biomark diagnosi drug resist identif treatment evalu advers drug reaction predict tuberculosi aim inspir novel precis therapi develop combat pathogen futur
|
D014376;D009169
|
T047;T007
|
36,311,753
|
identif hub gene correl infiltr immun cell mycn posit neuroblastoma base wgcna lasso algorithm prognosi mycn posit nb poor target drug n myc present studi aim screen hub gene close relat mycn analyz relationship hub gene nb microenviron provid basi molecular target therapi mycn posit nb
|
D009447
|
T191
|
36,311,752
|
kynuren acid amelior nlrp inflammasom activ block calcium mobil via gpr inflammasom link divers inflammatori metabol diseas tight control inflammasom activ necessari avoid excess inflamm kynuren acid ka tryptophan metabolit kynurenin pathway howev role mechan regul inflammasom activ ka yet fulli elucid found ka suppress caspas activ il product macrophag specif inhibit canon noncanon activ nlrp inflammasom mechanist ka reduc calcium mobil g protein receptor gpr result reduc mitochondri damag decreas mtros product thus block nlrp inflammasom assembl activ import ka prevent lipopolysaccharid induc system inflamm monosodium urat induc periton inflamm high fat diet induc metabol disord thus ka amelior inflamm metabol disord block calcium mobil mediat nlrp inflammasom activ via gpr data reveal novel mechan ka modul inflammasom activ suggest gpr might promis target improv nlrp inflammasom associ diseas regul calcium mobil
|
D058847;D000071199
|
T123;T116
|
36,311,750
|
immun infiltr signatur base classif reveal cd cd cell associ colorect cancer prognosi respons immunotherapi current stratif system tumor prognost predict immunotherapeut efficaci evalu less satisfi colorect cancer crc infiltr immun cell tumor microenviron tme play key role tumor progress respons immun checkpoint blockad icb therapi want construct immun relat score system detail immun profil stratifi crc patient
|
D013601;D015179
|
T191;T025
|
36,311,749
|
role microbiom metabolit ankylos spondyl ankylos spondyl chronic condit common influenc spine sacroiliac joint usual progress stiff progress function limit fundament etiolog pathogenesi like multifactori remain elus environment factor gut microbiota perform critic function pathogenesi various mechan includ interact gene enhanc intestin permeabl activ gut mucosa immun system affect intestin microbiota metabolit review provid overview recent advanc investig gut microbiota pathogenesi discuss potenti method futur therapeut intervent
|
D013167;D000069196
|
T047;T007;T001
|
36,311,748
|
effect microenviron osteosarcoma chemoresist promis immunotherapi osteosarcoma therapeut modal osteosarcoma os one common primari malign tumor origin bone high malign typic manifest lung metastasi lead high mortal although remark advanc surgic resect neoadjuv chemotherapi lengthen life expect great improv surviv rate among os patient breakthrough achiev challeng treat patient chemoresist tumor distant metastas recent studi identifi compel set link hypoxia chemotherapi failur review evid support posit effect hypoxia tumor microenviron tme addit certain anticanc effect immun checkpoint inhibitor demonstr os preclin model continu long term observ clinic trial requir present review discuss mutualist effect tme os treatment summar mechan immunotherapi interact tme use treat os also suggest immunotherapi new comprehens potenti antitumor approach stimul immun respons elimin tumor cell may repres innov approach develop novel treatment regimen os patient
|
D001859;D012516
|
T191
|
36,311,747
|
reshap tumor microenviron versatil immunomodulatori drug b cell neoplasm immunomodulatori drug imid thalidomid lenalidomid pomalidomid antitumor compound direct tumoricid activ indirect effect mediat multipl type immun cell tumor microenviron tme imid shown remark therapeut efficaci set b cell neoplasm includ multipl myeloma b cell lymphoma chronic lymphocyt leukemia recent advent immunotherapi revolution treatment b cell neoplasm howev success immunotherapi restrain immunosuppress signal dysfunct immun cell tme due pleiotrop immunobiolog properti imid shown generat synerget effect preclin model combin monoclon antibodi immun checkpoint inhibitor car cell therapi success translat clinic lead improv respons first line relapsedrefractori set mechanist despit cereblon crbn e ubiquitin ligas consid consid major molecular target respons antineoplast activ imid exact mechan action imid base tme educ remain larg unknown review present overview imid regul immun cell function util potenti efficaci immunotherapi across multipl type b cell neoplasm
|
D009101;D016393
|
T191
|
36,311,746
|
liver resid immun cell repertoir boon bane machin perfus liver propos import immun organ bodi critic involv varieti specif uniqu immun task contain huge resid immun cell repertoir determin balanc toler inflamm hepat microenviron liver resid immun cell popul sinusoid space diss includ profession antigen present cell myeloid cell well innat adapt lymphoid cell popul machin perfus mp emerg innov technolog preserv organ ex vivo test organ qualiti function prior transplant liver hypotherm normotherm mp techniqu success implement clinic routin especi use margin donor liver although evid ischemia reperfus injuri associ inflamm reduc machin perfus liver littl known whether mp impact quantiti activ state function hepat immun cell repertoir affect inflammatori milieu mp point remain even specul liver resid immun cell primarili exert pro inflammatori henc destruct effect machin perfus organ part may essenti induc liver regener counteract liver damag review discuss role hepat immun cell subtyp inflammatori condit ischemia reperfus injuri context liver transplant highlight possibl impact mp modif immun cell repertoir potenti futur applic immun modul liver
|
D009926;D015427
|
T061;T037
|
36,311,745
|
diagnost accuraci european leagu rheumatismamerican colleg rheumatolog versus system lupus intern collabor clinic versus acr classif criteria adult system lupus erythematosus systemat review meta analysi evalu diagnost perform american colleg rheumatolog acr system lupus intern collabor clinic slicc european leagu rheumat eular acr classif criteria adult patient system lupus erythematosus sle
|
D012219;D008180;D012216;D008178
|
T047;T091
|
36,311,744
|
prdx gene polymorph sle suscept chines popul system lupus erythematosus sle complex multisystem autoimmun diseas character product autoantibodi although accumul evid suggest dysregul long non code rnas lncrnas involv pathogenesi sle genet contribut lncrna code gene sle suscept remain larg unknown aim provid evid role lncrna code gene sle suscept
|
D062085;D008180
|
T123;T047;T114
|
36,311,743
|
associ dengu infect anti alpha gal antibodi igm igg igg igg dengu virus denv transmit aed mosquito etiolog agent dengu fever one fastest grow reemerg mosquito born diseas planet fold surg last five decad interest mani arthropod born pathogen includ denv type report contain immunogen glycan galactos alpha galactos alpha gal agal agal molecul common oligosaccharid found mani microorgan mammal except human old world primat loss agal human consid evolutionari innov enabl product specif antibodi agal could present glycan pathogen object studi evalu differ anti agal antibodi igm igg igg igg peopl expos denv observ signific differ anti agal igg igg level among dengu sever classif furthermor signific posit correl observ anti agal igg number day dengu symptom patient addit anti agal igm igg level differ two geograph locat patient anti agal igm igg level signific differ accord dengu sever level age negat correl anti agal igm posit correl anti agal igg signific involv agal antibodi dengu infect process suggest base result result open need studi exact role mechan agal antibodi dengu infect
|
D003716;D003715
|
T005;T047
|
36,311,742
|
non invas measur tumor immun microenviron predict surviv chemotherapeut benefit f fluorodeoxyglucos petct imag gastric cancer tumor immun microenviron could provid prognost predict inform necessari develop noninvas radiom base biomark previous valid tumor immun microenviron signatur gastric cancer gc immunohistochemistri stain
|
D019788;D013274
|
T191;T130;T109
|
36,311,740
|
perform clinic assess scale autoimmun enceph pediatr autoimmun enceph cohort clinic assess scale autoimmun enceph case new scale use rate sever autoimmun enceph ae demonstr good valid reliabl adult ae shortag data perform children ae studi aim assess reliabl valid case cohort children ae
|
D050031;D060426
|
T047
|
36,311,739
|
hla relat genet suscept autoimmun hepat accord autoantibodi profil although preval autoimmun hepat first degre relat small relationship genet marker especi human leucocyt antigen hla suscept diseas studi three decad genet suscept aih believ differ two subtyp diseas aih type aih type type aih anti smooth muscl anti nuclear antibodi main marker type aih anti liverkidney microsom type anti liver cytosol type antibodi anti solubl liver antigenliv pancrea antibodi addit present subtyp mark import number patient without serolog marker therefor third type diseas question vast major immunogenet studi compar differ two main type make differ antibodi present defin subtyp review seek analyz import publish aih context tri relat hla allel accord aih marker autoantibodi
|
D019693
|
T047
|
36,311,738
|
time esophagectomi follow neoadjuv immunochemotherapi local advanc esophag squamous cell carcinoma affect outcom neoadjuv immunochemotherapi nict novel pattern local advanc esophag squamous cell carcinoma escc time surgeri tts recommend week howev patient prolong tts week studi aim explor whether prolong tts week would affect outcom
|
D000077277;D004938
|
T191
|
36,311,737
|
function variant rs cfb confer low risk iga nephropathi attenu complement altern pathway activ han chines activ altern pathway ap complement thought play import role immunoglobin nephropathi igan previous studi show rs within complement factor b cfb gene increas risk igan protein encod cfb gene initi factor promot ap activ aim studi investig whether variant cfb confer suscept igan elucid potenti role ap activ total patient igan healthi control enrol five tag singl nucleotid polymorph select genotyp level key ap compon cfb complement factor h complement split product ca measur enzym link immunosorb assay molecular dock molecular dynam simul carri character mutat residu protein structur dynam properti wide type mutat model cfb protein allel specif effect cfb express bind affin cb investig cell transfect surfac plasmon reson analysi respect found rs signific reduc risk igan ci p rs rw mutat correl lower cfb level higher serum c level less mesangi c deposit patient igan structur model show rw mutat reduc structur stabil cfb protein furthermor vitro studi reveal rs decreas express cfb reduc bind affin cb four fold compar rs c conclus rs cfb associ low risk igan probabl attenu ap activ
|
D011415;D005922
|
T129;T047;T126;T116
|
36,311,736
|
symptomatolog previous sar cov infect serostatus vaccin influenc immunogen bntb covid mrna vaccin public health vaccin recommend covid primari seri booster previous infect individu differ worldwid infect sar cov often asymptomat remain determin vaccin immunogen compar previous infect subject studi present detail immunolog evid clarifi requir one two dose primari vaccin seri natur prime individu main object evalu immun respons covid mrna vaccin establish appropri vaccin regimen induc robust immun respons individu prior sar cov infect main outcom measur function immun score zero three vaccin base anti rbd igg level serum capac neutral live virus ifn secret capac respons sar cov peptid pool one point attribut three function assay respons posit threshold immun score compar base subject symptom diagnosi andor serostatus prior vaccin none nave particip n show maxim immun score three follow one dose vaccin compar previous infect particip n recov individu immun score three seroneg prior vaccin report symptom result initi infect follow one dose vaccin immun respons compar nave individu signific weaker respons individu symptomat infect result indic absenc symptom initi infect negat serostatus prior vaccin predict strength immun respons covid mrna vaccin altogeth find highlight import administ complet two dose primari regimen follow booster mrna vaccin individu experienc asymptomat sar cov infect
|
D000086382;D014765
|
T129;T047;T121;T067
|
36,311,735
|
bite hand feed metabol determin cell fate infect metabol shift occur cell innat immun system respons microbi infect whether metabol shift benefit host defens propag immun respons appear context depend arm race host adapt microb mammalian cell vie control biosynthet machineri organell metabolit herein discuss intersect host metabol cell intrins immun implic cell fate infect sensat microbi ligand isol result host metabol shift imbu normal innat immun function cytokin secret howev live microb arsenal effector strategi subvert cell intrins immun respons manipul host metabol consequ host metabol monitor indic invas manipul pathogen primarili action guard protein inflammasom pathway review frame initi cell intrins immun context host metabol includ physiolog goldilock zone allow shift guard circuit monitor wide perturb away zone initi innat immun respons comparison studi purifi microbi ligand dead microb live pathogen may begin understand shift metabol determin outcom host pathogen interact
|
D007113;D054884
|
T040;T032
|
36,311,734
|
metabol reprogram tumor immun microenviron ovarian cancer novel orient immunotherapi ovarian cancer lethal gynecolog tumor highest mortal rate numer studi conduct treatment ovarian cancer hope improv therapeut outcom immun cell reveal play dual function develop ovarian cancer act tumor promot tumor suppressor increas tumor immun microenviron time propos confirm play uniqu role tumor develop treatment alter immunosuppress cytotox respons vicin tumor cell metabol reprogram furthermor studi immunometabol provid new insight understand time target activ metabol process time potenti antitumor therapi modal review summar composit time ovarian cancer metabol reprogram relationship drug resist ovarian cancer recent research advanc immunotherapi
|
D010051;D000970
|
T121;T191;T109
|
36,311,733
|
antigen process present signatur prognost evalu immunotherapi select advanc gastric cancer aim studi propos signatur base gene associ antigen process present apscor predict prognosi respons immun checkpoint inhibitor ici advanc gastric cancer agc
|
D000074322;D013274
|
T129;T121;T191;T116
|
36,311,732
|
booster dose mrna vaccin augment wane cell antibodi respons sar cov gradual decay humor cellular immun respons time upon sar cov vaccin may caus lack protect immun conduct longitudin analysi antibodi cell monocyt particip vaccin mrna chadox week rd booster dose mrna vaccin observ substanti increas antibodi cd cell specif spike protein sar cov vaccin moreov vaccin induc activ cell express cd cd produc ifn tnf virus specif cd cell show predomin memori phenotyp although level antibodi frequenc virus specif cell reduc month nd dose augment rd dose follow decreas later import cell generat rd vaccin also reactiv omicron variant indic similar level ifn product stimul omicron peptid breakthrough infect particip vaccin two dose induc sar cov specif cell booster vaccin found upregul pd l express monocyt accumul myeloid cell mdsc like immunosuppress phenotyp vaccin result indic rd vaccin foster antibodi cell immun respons independ vaccin type use first two inject howev immun respons attenu time suggest therebi need vaccin
|
D014765;D000086382
|
T129;T047;T121;T067
|
36,311,731
|
dysregul b famili associ tumor microenviron uveal melanoma uveal melanoma uvm common primari intraocular malign adult poor prognosi b famili import modul immun respons howev dysregul under molecular mechan uvm still remain unclear
|
D059016;D014604
|
T070;T191
|
36,311,730
|
complement target therapi kidney transplant insight preclin studi aberr activ complement system contribut solid organ graft dysfunct failur kidney transplant complement system implic pathogenesi antibodi cell mediat reject ischemia reperfus injuri vascular injuri led evalu select complement inhibitor eg c c inhibitor clinic trial mix result howev complement system high complex compos fluid phase surfac bound element includ sever complement activ receptor potenti therapeut target kidney transplant generat target pharmaceut use gene edit tool led improv understand intricaci complement system allo xeno transplant review summar current knowledg role complement system relat reject kidney transplant specif review evid gain pre clinic model rodent nonhuman primat may potenti translat clinic trial
|
D016030;D016377
|
T061
|
36,311,729
|
bibliometr analysi cell atherosclerosi atherosclerosi widespread develop circulatori system problem cell play essenti regulatori role occurr develop far bibliometr research cell learn cell develop record retriev web scienc core collect record scientometr analyz use citespac vosview term spatiotempor distribut author distribut subject categori topic distribut refer keyword analysi provid basic inform research field demonstr field stabil past decad identifi potenti partner interest research current research hotspot field main includ inflammatori mechan immun mechan relat diseas relat cytokin b cell mortal inhibit monocyt repres frontier research field undergo explos phase hope work provid new idea advanc scientif research clinic applic cell
|
D015706;D050197
|
T062;T047;T046
|
36,311,728
|
cxcr express cell function role control tumor cxcr receptor chemokin cxcl exist membran solubl form cxcr marker resid memori rm cell play role immunosurveil interact epitheli cell interact cxcr cxcl express membran certain subpopul intratumor dendrit cell dc call dc ideal posit cxcr cell receiv prolifer signal il also present dc mice defici cxcr block interact cxcr ligand experi poorer control tumor prolifer cd cell also nkt cell especi liver intranas vaccin induc cxcl product lung associ infiltr rm express cxcr requir efficaci anti tumor vaccin therapeut addit cxcr specif car cell enhanc intratumor accumul prolong surviv anim model pancreat ovarian lung cancer final cxcr part immunolog signatur predict respons immunotherapi base anti pd l various cancer contrast protumor role cxcr cell also report main non alcohol steatohepat nash due non antigen specif mechan target amplif antigen specif rm express cxcr potenti use biomark respons immunotherapi open new perspect cancer treatment
|
D009369;D055611
|
T191;T025
|
36,311,727
|
irgitacon increas il releas allevi mechan thermal hypersensit mice nerv injuri inflamm play import role occurr develop neuropath pain immun respons gene irg decarboxyl cis aconit produc itacon mitochondria itacon serv immunomodul macrophag repress inflamm infecti diseas recent studi show itacon deriv inhibit neuroinflamm reduc chronic pain mice howev function molecular mechan endogen itacon neuropath pain fullyelucid studi content itacon ipsilater spinal cord nerv injur mice detect mass spectrometri irg mous construct determin role endogen itacon chronic constrict nerv injuri cci model analges effect exogen itacon assess intraperiton intrathec administr male femal cci mice spinal applic oi also reduc evok respons wide dynam rang neuron cci mice potenti analges mechan itacon explor molecular biolog experi verifi interleukin il mice found level itacon irg spinal cord signific increas cci irg defici aggrav mechan heat hypersensit exogen administr itacon deriv oi allevi neuropath pain male femal cci mice mechanist treatment oi increas level il activ stat endorphin pathway spinal cord analgesia effect itacon impair il mice final show upregul il induc oi main spinal neuron nrf pathway studi demonstr analges effect endogen exogen itacon neuropath pain model suggest spinal il stat endorphin pathway might mediat analgesia effect itacon
|
D016753;D009437
|
T129;T047;T116;T184
|
36,311,726
|
identif explor pharmacolog pyroptosi relat biomark ulcer coliti ulcer coliti uc chronic inflammatori bowel diseas ibd etiolog unclear much evid suggest death abnorm intestin epitheli cell iec lead intestin barrier disrupt subsequ inflammatori respons play vital role uc pyroptosi form program inflammatori cell death role pyroptosi uc etiolog remain explor studi identifi hub gene pyroptosi gene express profil obtain gse dataset meanwhil biomark screen base gene signific gs modul membership mm weight gene co express network analysi wgcna follow analysi indic hub gene close associ uc progress therapeut drug respons singl cell rna scrna sequenc data uc patient within gse dataset indic macrophag relat pyroptosi final express hub gene respons therapeut drug aminosalicyl acid asa verifi dextran sulfat sodium dss induc coliti mice studi identifi ilb critic pyroptosi relat biomark uc crosstalk macrophag pyroptosi iec pyroptosi may play essenti role uc deserv explor
|
D003092;D003093
|
T047
|
36,311,725
|
perturb mesenchym stromal cell allogen hematopoiet cell transplant predispos bone marrow graft versus host diseas function impair bone marrow bm nich suggest major reason prolong cytopenia secondari graft failur allogen hematopoiet cell transplant allohct mesenchym stromal cell mscs serv multipot progenitor sever nich compon bm might play key role process use collagenas digest trephin biopsi direct quantifi mscs patient n andor allohct n first time demonstr acut graft versus host diseas agvhd n associ signific decreas msc number msc reduct observ even clinic onset agvhd n assess mscs instant biopsi collect reveal phenotyp function differ depend occurr agvhd differ vanish ex vivo expans msc endotyp observ reveal enhanc popul donor deriv classic dendrit cell type alloreact cell caus agent compartment inflamm msc damag clinic onset agvhd ascertain conclus mscs endotyp may constitut predispos conductor alloreact allohct preced clinic diagnosi agvhd
|
D006086;D045164;D018380;D059630
|
T061;T047;T025
|
36,311,724
|
role radiotherapi relat autophagi gene prognosi immun infiltr lung adenocarcinoma close relationship radiotherapi autophagi tumor prognost role radiotherapi relat autophagi gene rrag lung adenocarcinoma luad remain unclear
|
D008175;D000077192
|
T191
|
36,311,723
|
long term cellular immun respons immunocompromis unvaccin covid patient undergo monoclon antibodi treatment immunocompromis patient increas risk sever cours covid treatment sever acut respiratori syndrom coronavirus sar cov infect anti sar cov monoclon antibodi mab becom wide accept howev effect mab treatment long term primari cellular respons sar cov unknown follow studi investig long term cellular immun respons sar cov spike membran nucleocapsid n antigen use elispot assay unvaccin mab treat immunocompromis high risk patient anti sar cov mab untreat though vaccin covid immunocompromis patient vaccin sar cov immunocompromis patient without covid vaccin healthi control subject serv control group cellular immun respons determin median month sar cov infect data suggest immunocompromis patient develop endogen long term cellular immun respons covid although low level better understand cellular immun respons help guid clinic decis make vulner patient cohort
|
D000086382
|
T047;T067
|
36,311,722
|
gasdermin protect streptococcus equi subsp zooepidemicus infect macrophag pyroptosi streptococcus equi subsp zooepidemicus zooepidemicus sez essenti zoonot bacteri pathogen caus various inflamm mening endocard pneumonia gasdermin gsdmd involv cytokin releas cell death indic import role control microbi infect studi investig protect role gsdmd mice infect sez examin role gsdmd periton macrophag infect gsdmd defici mice suscept intraperiton infect sez white pulp structur spleen serious damag gsdmd defici mice although increas proport macrophag depend gsdmd spleen periton lavag fluid plf defici gsdmd caus minor releas pro inflammatori cytokin interleukin il interleukin il infect vivo vitro sez infect induc releas il il lactat dehydrogenas ldh wild type macrophag gsdmd defici macrophag final demonstr pore format pyroptosi macrophag depend gsdmd find highlight host defens mechan gsdmd sez infect provid potenti therapeut target sez infect
|
D000069292;D018502
|
T007;T043
|
36,311,721
|
emerg role histon deacetylas allerg diseas histon deacetylas hdac uniqu member class hdac help regul acut chronic adapt environment stimuli allergen stress allerg diseas complex diseas result effect multipl genet interact foreign substanc epigenet play import role patholog immunomodulatori condit allerg diseas consist role recent evid strong suggest histon deacetylas hdac play critic role allerg respons hdac express stimul allergen attribut increas helper th cytokin level decreas thth cell anti inflammatori cytokin interleukin il twik relat potassium channel trek express review focus contribut hdac regulatori role character allerg endotyp common molecular pathway understand allerg multimorbid relationship well address potenti therapeut target condit
|
D056284;D006967
|
T046;T126;T116
|
36,311,720
|
multi trial analysi hiv envelop gp reactiv antibodi among global recipi candid hiv vaccin mani particip hiv vaccin trial previous expos vaccin hiv display serum immunoglobulin antibodi bind gp region hiv envelop prior vaccin previous studi hypothes pre exist antibodi may cross reactiv may skew futur vaccin respons larg studi conduct hiv vaccin trial network hvtn n individu find wide variat among particip pre vaccin level gp reactiv antibodi measur bind antibodi multiplex assay bama absenc exposur gp immunogen anti gp igg level tempor stabl week repeat measur placebo recipi analysi reveal geometr mean pre vaccin anti gp igg respons greater among particip south africa compar particip unit state gene level metagenom sequenc pre vaccin fecal sampl collect particip one trial hvtn detect posit associ pre vaccin anti gp igg abund gene multipl taxa eubacterial order gene strong associ higher baselin anti gp igg map clade contain blautia wexlera close relat strain trial vaccin product contain full partial portion gp immunogen alongsid gp immunogen find evid individu higher baselin anti gp igg differ level anti gp igg vaccin compar individu lower pre vaccin anti gp level pool estim standard mean differ ci
|
D015497;D016915;D015658;D006679
|
T129;T121;T005;T047;T034
|
36,311,719
|
human milk proteom allergi mother child explor associ protein abund protein network connect human milk proteom compris vast number protein immunomodulatori function clear relat allergi mother allergi develop breastf infant studi aim explor relat human milk proteom allergi mother child
|
D008895;D005512
|
T046;T031
|
36,311,718
|
immunoinformat base design immun boost multiepitop subunit vaccin monkeypox virus valid molecular dynam immun simul monkeypox virus causat agent monkeypox diseas belong orthopoxvirus genus diseas pattern similar smallpox number monkeypox case robust increas recent sever countri around world potenti caus intern threat therefor serious measur indispens taken mitig spread diseas henc circumst vaccin best choic neutral monkeypox virus current studi use immunoinformat approach target lr br ar protein monkeypox virus screen immunogen cytotox lymphocyt ctl helper lymphocyt htl b cell epitop construct multiepitop subunit vaccin various onlin tool predict best epitop immunogen target lr br ar monkeypox virus predict epitop join togeth differ linker subject structur predict molecular dynam simul analysi confirm proper fold model protein strong bind construct vaccin human tlr verifi molecular dock determin dissoci constant valu gc content codon adapt index cai valu confirm high express construct vaccin pet express vector immun respons simul data delin inject vaccin robust activ immun system trigger product high titer igg igm antibodi conclus studi provid solid base concept develop dynam effect vaccin contain sever monkeypox virus deriv high antigen nonallergen peptid control current pandem monkeypox virus
|
D008993;D045908
|
T005;T047
|
36,311,717
|
narcolepsi hn influenza immunolog decad later learn wake acalifornia hn influenza pandem vaccin campaign increas incid chronic sleep wake disord narcolepsi detect children adolesc sever european countri last decad depth epidemiolog immunolog studi conduct investig associ advanc understand event underpin observ risk narcolepsi cataplexi defin type narcolepsi nt character irrevers chronic defici hypocretin peptid hypothalamus multifactori etiolog thought includ genet predisposit head trauma environment trigger andor infect includ influenza virus infect increas risk observ follow administr acalifornia hn vaccin pandemrix gsk autoimmun origin nt broad assum base strong associ predispos allel human leucocyt antigen dqb carri larg major nt patient link immun relat genet marker affect risk nt present hypothes under potenti immunolog mechan center molecular mimicri hypocretin peptid within acalifornia hn virus antigen molecular mimicri may instig cross reactiv autoimmun respons target hypocretin produc neuron local cd cell respons recogn peptid hypocretin thought play central role respons model cross reactiv dqb restrict cell peripheri would activ cross blood brain barrier rare possibl pathogen instig inflammatori process brain current hypothes suggest activ expans cross reactiv cell hn influenza infect could amplifi follow administr adjuv vaccin give rise two hit hypothesi collect silico vitro preclin vivo data recent ongo research progress refin hypothet model sequenti immunolog event fill multipl knowledg gap though definit conclus drawn mechanist model plausibl explain increas risk nt observ follow hn pandem subsequ vaccin campaign outlin review
|
D007251;D053118;D009290
|
T047;T005
|
36,311,716
|
interleukin dna complex promot inflamm dermal epiderm separ modifi human cryosect model bullous pemphigoid bullous pemphigoid bp autoimmun diseas character autoantibodi mediat activ immun cell subepiderm blister format excess amount extracellular dna produc bp howev remain unclear extracellular dna contribut bp pathogenesi show possibl mechan interleukin il bind extracellular dna releas neutrophil eosinophil support dna sens patient bp exhibit high circul level il form il dna complex upper dermi insid blister il dna complex play dual role regul local immun blister format first enhanc product inflammatori cytokin monocyt neutrophil second import complex augment product activ proteas co cultur monocyt neutrophil induc bp cleavag keratinocyt dermal epiderm separ modifi human cryosect model collect propos model il extracellular dna synergist act immun cell enhanc autoantibodi driven local immun respons proteas mediat fragil dermal epiderm junction bp
|
D010391
|
T047
|
36,311,715
|
case report anlotinib combin pd inhibitor sequenti ga regimen folfirinox chemotherapi treatment kras gv mutat pancreat ductal adenocarcinoma liver metastasi case literatur review high mortal rate associ pancreat cancer incid rise global recent decad patient diagnos littl chanc surgeri benefici system chemotherapi current accept treatment option patient metastat advanc pancreat cancer howev limit surviv improv possibl chemotherapi advanc pancreat cancer chemotherapi resist play signific role poor prognosi despit fact target growth factor receptor inhibitor anti vascular endotheli growth factor vegfr antibodi signific improv surviv pancreat cancer small number patient benefit treatment emerg drug immun checkpoint inhibitor ici demonstr signific therapeut effect sever tumor type monotherapi effect pancreat cancer first line treatment solid tumor combin therapi may result remark outcom report younger patient pancreat ductal adenocarcinoma liver metastasi pdaclm long term partial respons good toler combin anlotinib program cell death protein pd inhibitor chemotherapi gene analysi suggest one mutat kirsten rat sarcoma viral oncogen kras gv gene consequ hope patient pancreat cancer especi kras gv gene mutat patient upon review literatur patient combin therapi first report
|
D010190;D021441;D008113
|
T191
|
36,311,714
|
role organ deposit igg pathogenesi multi organ tissu damag system lupus erythematosus system lupus erythematosus sle often known simpli lupus sever chronic autoimmun diseas character multi organ tissu damag high level autoantibodi serum recent investig use anim model role organ deposit igg autoantibodi pathogenesi organ tissu damag sle found intra organ inject serum mice lupus ie lupus mice healthi mice trigger inflamm tissu organ serum healthi mice sever inflamm relat dose serum inject immunohistochemistri show larg number igg molecul deposit site organ tissu damag lupus mice igg major contributor develop tissu inflamm trigger serum lupus mice patient develop tissu inflamm induc igg serum lupus mice requir presenc monocytesmacrophag lymphocyt neutrophil tumor necrosi factor tnf tumor necrosi factor receptor tnfr interleukin il also play essenti role develop tissu inflamm trigger igg addit found tnfr inhibitor suppress skin injuri lupus mice spleen tyrosin kinas syk inhibitor block signal transduct iggfc gamma receptor fcrs prevent treat skin injuri kidney damag lupus mice also observ lupus igg might protect bone eros base result conclud igg play crucial role develop organ tissu damag sle protect bone eros arthriti suggest iggfcr signal pathway import therapeut target sle
|
D047888;D008180
|
T129;T047;T116;T192
|
36,311,713
|
neuropsycholog decrement midlif type diabet associ peripher nlrp inflammasom respons midlif type diabet mellitus tdm associ increas risk alzheim diseas ad later life alter inflammatori respons postul key patholog driver previous studi demonstr increas respons nlr famili pyrin domain contain nlrp inflammasom agonist individu untreat tdm addit establish ad hypothesis peripher nlrp inflammasom respons may alter earli stage tdm relat cognit dysfunct assess relationship nlpr respons peripher blood mononuclear cell includ putat pathogen protein ad neuropsycholog perform uncompl midlif tdm identifi earli signatur immun dysregul may predispos later cognit declin recruit cross section cohort middl age adult uncompl tdm match healthi control hcs comprehens neuropsycholog assess vitro pbmc respons rang nlrp agonist assess tdm associ subtl decrement neuropsycholog test delay memori execut function p overal differ tdm hcs immun respons induc nlrp agonist observ relationship subtl neuropsycholog decrement observ tdm pbmc respons nlrp agonist data suggest peripher nlrp inflammasom respons dysregul may play role earli stage cognit dysfunct midlif tdm longitudin studi warrant examin contribut peripher nlrp respons toward diseas patholog cognit declin acceler tdm
|
D000544;D003924
|
T047;T048
|
36,311,711
|
anti srp immun mediat necrot myopathi critic review current concept review aim describ clinic histolog featur treatment prognosi patient anti signal recognit particl srp autoantibodi posit immun mediat necrot myopathi srp imnm base previous find
|
D009220;D001327;D009135
|
T047
|
36,311,709
|
therapeut effect alveolar echinococcosi target em leucin aminopeptidas alveolar echinococcosi ae parasit diseas caus e multiloculari metacestod high preval northern hemispher previous found vaccin e multiloculari leucin aminopeptidas em lap induc specif immun respons inhibit effect parasit studi therapeut effect recombin em lap rem lap ae evalu verifi use ubenimex broad spectrum inhibitor lap result reveal rem lap could inhibit cyst growth invas induc specif immun respons balbc mice infect e multiloculari protoscolec ultrason mri morpholog result show treatment rem lap inhibit e multiloculari infect reduc cyst weight number fibrosi invas effect observ treatment ubenimex inhibit lap activ indirect elisa show rem lap could induc specif immun respons produc high level igg igg igga igm iga serum level ifn il signific increas compar control group indic treatment rem lap lead th th mix type immun respons studi suggest em lap could potenti therapeut target e multiloculari infect
|
D048210;D004443;D003560
|
T047;T190;T204
|
36,311,708
|
prognost analysi valid diagnost marker gene patient osteoporosi system skelet dysfunct osteoporosi op character low bone mass bone microarchitectur damag global incid op high
|
D035683;D010024
|
T123;T047;T114
|
36,311,707
|
bibliometr visual analysi mesenchym stem cell rheumatoid arthriti rheumatoid arthriti ra chronic autoimmun diseas lead joint deform loss function recent studi shown great progress research mesenchym stem cell mscs ra howev thus far bibliometr visual analys field bibliometr analysi provid comprehens overview general inform research hotspot mscs ra
|
D001172;D059630
|
T047;T025
|
36,311,706
|
evolut surrog light chain tetrapod relationship length cdr h vpreb tail mammalian immun system surrog light chain slc shape antibodi repertoir b cell develop serv checkpoint product function heavi chain hc structur studi indic tail region vpreb contact cover third complementar determin region hc cdr h howev speci particular bovin cdr h region may compat hc slc interact model immens structur genet divers antibodi repertoir across speci evalu genet origin sequenc featur surrog light chain compon examin tetrapod genom evid conserv gene synteni determin evolutionari origin vpreb vpreb igll well vpreb pre cell receptor alpha ptcra gene found gene slc compon vpreb vpreb igll eutherian mammal howev gene ptcra occur amniot group gene vpreb occur tetrapod group gene high conserv addit found evid new vpreb gene non mammalian tetrapod similar vpreb gene eutherian mammal suggest vpreb may appear earlier tetrapod evolut may precursor tradit vpreb gene higher vertebr among eutherian mammal sequenc conserv vpreb vpreb low group except rabbit rodent vpreb near ident vpreb share conserv synteni vpreb speci vpreb rabbit rodent like repres duplic variant vpreb distinct vpreb mammal thus rabbit rodent two variant vpreb vpreb vpreb vpreb sequenc analysi vpreb tail region indic differ sequenc content charg length repertoir data avail observ signific relationship vpreb tail length maximum dh length posit slc compon co evolv immunoglobulin hc accommod repertoir particular cdr h length structur perhap high unusu hc like ultralong hc cattl may bypass development checkpoint altogeth
|
D013623;D007147
|
T129;T023;T116
|
36,311,704
|
combin oral immun probiot entercoccus faecali deliv surfac anchor eimeria tenella protein provid protect efficaci homolog infect chicken avian coccidiosi intestin parasit diseas exert high negat impact global poultri industri aim present studi evalu immun protect efficaci eimeria tenella infect chicken oral immun combin recombin probiot entercoccus faecali e faecali deliv surfac anchor e tenella protein
|
D016786;D016052;D011201;D019936
|
T129;T121;T007;T204;T047
|
36,311,703
|
pan cancer analysi reveal relationship rcsd immun infiltr clinic prognosi human tumor rcsd cytoskelet regul confirm undergo genet mutat hematolog tumor mechan rcsd pan cancer impact patient prognosi studi
|
D000077192;D008175;D002289
|
T191
|
36,311,702
|
target tumor associ macrophag immunotherapi glioblastoma navig clinic translat landscap tumor associ macrophag tam direct clear tumor cell enhanc phagocyt abil immun cell abund tam site glioblastoma tumor indic tam target immunotherapi could repres potenti form treatment aggress cancer herein discuss dynam role tam glioblastoma ii describ format immunosuppress tumor microenviron iii summar latest clinic trial data reveal tam function regul favor tumor erad last iv evalu implic exist novel translat approach treat glioblastoma clinic practic
|
D005909
|
T191
|
36,311,701
|
mrna vaccin unmodifi uridin induc robust type interferon depend anti tumor immun melanoma model mrna unmodifi nucleosid induc type interferon ifn stimul innat immun sensor whether ifn induc mrna vaccin crucial anti tumor immun respons remain elucid studi investig immunogen anti tumor respons mrna encod tumor antigen differ degre n methylpseudouridin modif b melanoma model result demonstr ovalbumin ova encod mrna formul lipid nanoparticl ova lnp induc substanti ifn product matur dendrit cell dcs negat correl increas percentag modif b ova murin melanoma model unmodifi ova lnp signific reduc tumor growth prolong surviv compar ova lnp modif robust anti tumor effect correl increas intratumor cd dcs frequenc granzym b ifn tnf polyfunct ova peptid specif cd cell block type ifn receptor complet revers anti tumor immun unmodifi mrna ova reflect signific decreas ova specif ifn secret cell enrich pd tumor infiltr cell robust anti tumor effect unmodifi ova lnp also observ lung metastat tumor model final mrna vaccin test use b melanoma neoantigen pbk actn result delay tumor growth taken togeth find demonstr unmodifi mrna vaccin induc ifn product downstream signal cascad play crucial role induc robust anti tumor cell respons control tumor growth metastasi
|
D008546;D007370
|
T121;T129;T050;T116;T191
|
36,311,700
|
oral vaccin fish vibriosi use spore display technolog oral vaccin high demand aquacultur sector allow mass deliveri antigen without use expens labor intens inject vaccin later requir individu handl fish provok stress relat mortal one possibl strategi creat inject free vaccin deliveri vehicl use bacteri spore extrem resist structur wide biotechnolog applic includ probiot display system adjuv bacteri spore particular bacillus subtili shown behav mucos vaccin adjuv mice model howev technolog extens explor fish bacteri diseas studi use laboratori strain b subtili varieti genet manipul tool avail display spore surfac either vibrio antigen protein ompk green fluoresc protein gfp previous vaccin immers ompk carri spore zebrafish surviv upon bacteri challeng v anguillarum v parahaemolyticus increas depend pathogen target abl detect anti gfp antibodi serum european seabass juvenil fed diet contain gfp carri spore anti v anguillarum antibodi serum european seabass juvenil fed ompk carri spore contain diet import seabass surviv increas previous oral vaccin feed ompk carri spore result indic b subtili spore effect use antigen carrier oral vaccin deliveri fish
|
D014735;D005393;D001492
|
T047;T013
|
36,311,699
|
correl serolog paramet diseas activ igg relat diseas differ patient normal elev serum igg concentr aim identifi serolog paramet correl diseas activ igg relat diseas igg rd patient normal elev serum igg concentr respect
|
D000077733
|
T047
|
36,311,698
|
h tex mediat signal hepatocellular carcinoma cell macrophag exosom target therapi hepatocellular carcinoma increas evid key role immun microenviron occurr develop hepatocellular carcinoma import compon immun microenviron polar state function macrophag determin mainten immunosuppress tumor microenviron hepatocellular carcinoma tumor deriv exosom inform carrier regul physiolog state cell microenviron control cancer progress review focus role exosom content diseas outcom differ stage progress hepat b virushepat c virus induc hepatocellular carcinoma also explor mechan macrophag contribut format hepatocellular carcinoma summar regul macrophag function heterogen exosom load liver cancer final rise exosom modif immunotherapi research hepatocellular carcinoma summar applic prospect exosom base target drug deliveri
|
D006528;D055354;D008113
|
T026;T191
|
36,311,697
|
clinic characterist hepat flare pregnanc postpartum chines chronic hepat b virus carrier prospect cohort studi case china common pregnant women high load hepat b virus hbv take nucleo ide analogu na prevent matern child transmiss hbv howev impact na intervent virolog biochem paramet pregnant postpartum women safeti drug cessat remain unclear prospect observ cohort establish studi analyz clinic characterist hepat flare pregnant postpartum chronic hbv carrier without na intervent
|
D019694;D011251
|
T047
|
36,311,645
|
physic environ research famili ward healthi residenti environ climat chang popul age two import global health challeng centuri studi environment protect agenc show averag peopl particular older adult spent time home even evid coronavirus diseas covid pandem home base care model becom new trend health comfort live environ profound impact wellb older adult therefor research physic environ famili ward becom inevit part promot health older adult howev current research still lack base studi analysi continu monitor data relat element physic environ thermal comfort acoust qualiti light qualiti indoor air qualiti famili ward paper explor live behavior particip environment research open close window air condit artifici light televis indoor physic environ refer requir intern standard indoor age friend physic environ also discuss analyz physic environ paramet valu accord chines standard peopl life behavior differ degre influenc element indoor physic environ exampl open door window allevi advers effect indoor environment qualiti human bodi better simpli turn air condition owe declin physic function older adult need special care studi status quo physic environment element propos suitabl environment improv measur age great signific research aim address global warm sever age contribut sustain environment develop
|
D000086382;D016902
|
T047;T069;T067;T080
|
36,311,644
|
creat empir base model social art public health resourc train typolog impact mount empir evid underscor health benefit art recent report scope review world health organ creativ art particular acknowledg public health resourc benefici well health within broad context subfield participatori art term social art sa specif refer art made social engag profession eg artist creativ art therapist social worker etc non profession determin togeth content final art product theater visual art music literatur etc aim produc meaning social chang sa enhanc individu communiti public health time sociopolit instabl activ field israel howev sa still investig field studi worldwid hard character typifi evalu paper present research protocol design examin tripartit empir base model sa cover wide rang sa train program implement impact find help refin definit sa inform practition trainer research well fund bodi policymak content impact sa project israel beyond
|
D001154;D009146
|
T090;T170
|
36,311,643
|
non linear associ composit dietari antioxid index depress grow evid shown antioxid diet protect factor depress howev relationship composit dietari antioxid index cdai import measur antioxid diet depress receiv littl attent therefor investig relationship cdai depress cross section analysi nation health nutrit examin survey nhane
|
D000975;D003863
|
T123;T121;T184;T039;T044;T048
|
36,311,642
|
patient attitud determin toward chronic diseas control cross section survey rural china patient attitud critic diseas control studi aim explor determin patient attitud satisfact
|
D012424;D006296
|
T058;T098;T102
|
36,311,640
|
built environ approach extens personnel prefer barrier facilit intervent modifi built environ increas popul physic activ level prevent chronic diseas nation cooper extens system pois implement built environ approach ie pedestrianbicycl infrastructur enhanc access physic activ space implement strategi ie method techniqu move research practic need improv uptak effect implement strategi address relev barrier capit facilit purpos studi understand barrier facilit implement built environ approach two state extens system prefer built environ approach prefer implement strategi
|
D015444;D009042
|
T061;T078;T080;T056;T041
|
36,311,639
|
lead exposur causat factor metabol associ fatti liver diseas mafld lead exposur relat nomogram mafld preval relationship lead exposur neurolog disord extens studi effect lead exposur hepatotox unknown metabol relat fatti liver diseas mafld updat previous non alcohol fatti liver diseas nafld redefin diagnost condit emphas metabol factor consid non alcohol factor lead affect endocrin system metabol believ lead exposur may contribut mafld individu undergon blood lead test nation health nutrit examin survey nhane databas select studi characterist popul lead exposur last decad effect lead exposur liver function whether lead exposur caus mafld analyz co variat adjust accord age ethnic bodi mass index bmi waist circumfer viscer adipos index vai poverti indic pir diabet hypertens hyperlipidemia result show blood lead concentr stabil low level decreas trend year year differ blood lead concentr associ differ age sex race educ level pir lead exposur independ risk factor mafld lead nine factor use independ risk factor mafld nomogram establish predict preval probabl mafld
|
D007854;D065626
|
T131;T196;T047
|
36,311,638
|
person protect equip associ headach health care worker covid systemat review meta analysi health care worker hcws use person protect equip ppe covid pandem protect prevent transmiss diseas use ppe especi respiratori mask advers consequ includ headach secondari unusu aim present systemat review meta analysi studi investig preval ppe associ headach hcws covid pandem
|
D000067393;D000086382
|
T047;T073;T067
|
36,311,637
|
particip mass dog vaccin campaign tanzania benefit communiti engag canin rabi caus human death year global diseas elimin sustain suffici dog vaccin coverag sever consecut year challeng achiev high coverag low particip dog owner vaccin campaign explor whether previous identifi contributori factor low particip address communiti engag activ
|
D004283;D011818
|
T047
|
36,311,636
|
short term exposur ambient fine particul matter psoriasi time seri analysi beij china ambient fine particul matter pm advers affect human health link varieti skin disord howev littl known effect pm psoriasi
|
D000397;D000393;D011565
|
T131;T047;T069;T080
|
36,311,635
|
effect full coverag polici essenti medicin medic adher quasi experiment studi taizhou china differ form full coverag polici essenti medicin fcpem adopt worldwid lower medic expenditur improv adher studi aim analys effect fcpem patient medic adher taizhou citi china
|
D006973;D003920
|
T047
|
36,311,634
|
effect vertic vibrat stimul differ frequenc delay muscl sore athlet random trial effect stimul differ vibrat frequenc delay muscl sore dom yet determin studi conduct investig effect medium high frequenc vertic vibrat stimul dom track field athlet
|
D063806;D014732
|
T184;T070
|
36,311,633
|
self collect capillari blood saliva determin covid vaccin immunogen patient immun mediat inflammatori diseas health profession abl independ determin vaccin induc antibodi respons minim invas method great interest enabl flexibl effect vaccin strategi studi aim evalu accuraci feasibl usabl accept capillari blood saliva self sampl determin sar cov antibodi respons patient immun mediat inflammatori diseas imid health profession hp
|
D000086663;D000086382
|
T200;T047;T067
|
36,311,632
|
covid ct featur vari patient within outsid mainland china find meta analysi chest computer tomographi ct play import role detect patient suspect coronavirus diseas covid howev systemat summari whether chest ct find patient within mainland china applic found patient outsid
|
D000086382
|
T047;T067
|
36,311,631
|
monkeypox world readi anoth pandem world continu endur impact covid pandem outbreak monkeypox occur continu spread unab doubl strand dna monkeypox virus sylvat zoonosi occasion infect human member genus orthopoxvirus although scientist believ virus low transmiss speed degre spread alarm could land one hospit even kill one addit fact unusu transmiss occur among peopl without travel histori endem region suggest undetect transmiss rais concern prepared anoth pandem contrari covid pandem vaccin could offer protect monkeypox virus therefor need coordin effort among author concern communiti base organ rais awar potenti pandem monkeypox activ surveil system laboratori capac heighten contact trace vaccin risk individu stem outbreak still opportun prevent becom pandem
|
D045908;D000086382
|
T047;T067
|
36,311,630
|
trend dynam gout preval among chines popul joinpoint age period cohort analysi burden gout increas worldwid place heavi burden societi healthcar system studi investig independ effect age period cohort gout preval china compar effect gender predict futur burden gout next decad
|
D006073
|
T047
|
36,311,628
|
social prescrib frequent attend primari care econom analysi social prescrib sp mechan link patient communiti group third sector organ offer complimentari approach tradit medic model address psychosoci need patient effect turn aim reduc demand nhs aim studi explor econom benefit relat chang use healthcar resourc follow social prescrib intervent four primari care practic wale
|
D011320
|
T058
|
36,311,626
|
influenc job environ onlin teach anxieti colleg teacher onlin teach context mediat role subject well onlin educ conduct wide higher educ recent year onlin teach bring mani opportun also pose numer challeng issu especi true colleg teacher teach consid profess high level burnout anxieti larg scale applic onlin teach method put teacher even challeng context may lead teach anxieti affect mental health onlin teach context question factor affect colleg teacher onlin teach anxieti worth explor help reduc onlin teach anxieti promot work perform studi therefor conduct survey colleg teacher develop model job environ job demand job resourc subject well onlin teach anxieti explor influenc job environ subject well onlin teach anxieti well mediat effect subject well job environ onlin teach anxieti
|
D002055
|
T048
|
36,311,625
|
death sea true rate occup fatal within australian commerci fish industri although safeti perform australian commerci fish industri subject multipl investig ultim remain undefin australian industri notifi industri regul signific workplac incid injuri oper major person commerci fish industri contractor paid piecework jurisdict specif exclud worker compens legisl mean occup injuri includ fatal captur central worker compens data set studi present analysi systemat review industri databas publish academ australian coron report assist improv definit nation commerci fish industri safeti perform analysi show occup fatal rate signific higher current report recur factor contribut death sea remain unaddress studi signific demonstr workplac injuri death hidden within data set appli broad industri classif provid foundat futur research australian fish industri
|
D000062;D000090262
|
T056;T067
|
36,311,624
|
experienc anticip wit discrimin covid pandem implic health wellb among asian american onset covid pandem spur increas racial animus toward asian asian american aaa sinc contend increas racism violenc harm associ increas prejudic may deriv person experienc discrimin covid pandem also mark increas vicari exposur discrimin well increas anticip discrimin may tax mental physic health aaa goal studi accord examin effect person experi discrimin vicari exposur discrimin anticip discrimin depress symptom physic health symptom sleep qualiti sleep disturb among aaa result two wave field survey demonstr experienc anticip discrimin associ mental physic health symptom well sleep disturb person experi discrimin interact vicari discrimin determin physic health symptom greater vicari exposur weaken relationship experienc discrimin physic health symptom find demonstr need mobil resourc combat multiprong negat implic recent rise anti asian prejudic covid pandem
|
D000086382;D063505;D012893
|
T054;T047;T067;T048
|
36,311,623
|
comprehens leagu tabl cost util ratio systemat review cost effect evid health polici decis india although relat recent concept develop countri develop world use leagu tabl polici guid tool comprehens assess health expenditur countri specif leagu tabl use tool nation healthcar plan budget present herewith comprehens leagu tabl cost per qualiti adjust life year qali disabl adjust life year dali ratio deriv health technolog assess hta econom evalu studi report india systemat review
|
D013673;D006291
|
T089;T058
|
36,311,622
|
posit mental health slovenia covid pandem mental health heavili affect covid pandem studi compar preval flourish languish mental health pandem examin factor associ either categori posit mental health respect
|
D008603;D000086382
|
T047;T067;T041
|
36,311,621
|
rapid investig baba case franc aim describ characterist individu infect ba ba franc comparison ba analyz factor associ hospit among ba ba case
|
D006760;D003371
|
T184;T058
|
36,311,620
|
blue sky protect factor cardiovascular diseas blue sky consid boost outdoor physic activ social interact amelior work pressur life stress enhanc peopl sens happi howev direct associ blue sky exposur cardiovascular diseas cvd still lack epidemiolog evid studi aim quantifi relationship via nationwid prospect cohort china
|
D002318;D000397;D020521
|
T047;T069;T080
|
36,311,619
|
comparison complianc among patient pediatr amblyopia undergo virtual realiti base tradit patch method train studi aim compar complianc pediatr patient amblyopia undergo smartphon virtual realiti base train method eyebit receiv tradit patch method train
|
D000550;D000076142
|
T047;T066
|
36,311,618
|
develop rural tourism china tragedi anti common develop rural tourism present complex industri environ govern coordin structur tourism develop due high dispers fragment properti right resourc object well involv mani atom properti right stakehold coupl lack strong organ leadership full develop util rich tourism resourc rural area becom problemat difficult realiz rental valu tourism resourc lead tragedi anti common take case china paper explor occurr anti common tragedi develop rural tourism identifi problem caus tragic govern anti common current environment develop examin govern path anti common tragedi tourism sector purpos studi optim develop environ rural tourism build healthi space suitabl industri resid tourism
|
D000085926;D004777
|
T056;T082;T067
|
36,311,617
|
sar cov transmiss prevent model applic larg retail compani vaccin introduct march follow spread sar cov declar pandem status impact nation health econom system huge therefor mani countri took measur restrict spread virus mani work activ subject lockdown measur howev product activ continu remain open ie larg scale food distribut food industri pharmaci hospit etc order contain spread pandem public health measur implement state reduc contagion virus workplac therefor import implement measur contrast contain spread sar cov covid workplac aim studi adopt implement safeti protocol use restrict spread sar cov larg scale retail trade compani locat south itali vaccin first second pandem phase also exploit telemedicin servic antibodi serolog test card also use first pandem wave rapid antigen swab second detect worker posit sar cov popul subject work anoth compani similar product activ distribut territori select control group work activ group follow minimum activ protocol provid italian legisl april ministri protocol provid daili monitor bodi temperatur case sar cov posit subject extraordinari sanit workplac measur implement identifi posit subject sar cov earli stage protocol made possibl signific reduc spread virus within larg scale retail distribut therefor avoid temporari closur store consequ reduct econom loss compar control group
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,311,616
|
seir model simul research unsaf psycholog state propag construct worker consid safeti climat intim relationship construct industri pillar industri china occupi essenti posit econom develop howev fast develop construct industri number safeti accid also grow year year safeti accid often due unsaf behavior construct worker unsaf precari psycholog state import factor unsaf behavior therefor paper base review exist literatur use seir model numer simul method studi spread unsaf psycholog state among construct worker consid safeti climat intim relationship put forward correspond countermeasur great practic signific reduc safeti accid construct industri result show good safeti climat help allevi spread unsaf psycholog state construct worker intim relationship construct worker promot associ communic peopl suscept peopl lead spread unsaf psycholog state larger network averag degre increas spread speed densiti communic peopl increas spread rang forget rate key role propag unsaf psycholog state suggest made hinder propag state help reduc unsaf behavior construct worker accid rate construct industri
|
D060389;D016272
|
T078;T090;T091
|
36,311,615
|
factor associ covid stigma onset global pandem india cross section studi assess factor associ covid stigmat attitud communiti stigma experi covid recov individu first wave covid pandem india
|
D058873;D000086382
|
T047;T067
|
36,311,614
|
associ extern beam radiotherapi overal surviv patient gallbladd cancer popul base studi lack studi regard radiotherapi rt patient gallbladd cancer gbc surviv benefit surgeri nonsurg treatment therefor studi evalu impact extern beam rt overal surviv os patient gbc real world set
|
D005706
|
T191
|
36,311,613
|
central adipos increas odd plasma folat defici among chines women reproduct age explor associ adipos plasma folat defici odd among women reproduct age china
|
D050154;D009765
|
T047;T032
|
36,311,612
|
experi percept telephon deliveri common element treatment approach mental health need among young peopl zambia covid pandem mental behavior health need immens low middl incom countri lmic particular adolesc young adult aya howev access mental health servic limit lmic due barrier distanc health care site low number provid structur logist challeng covid pandem barrier signific exacerb thus mental health servic sever disrupt potenti solut barrier remot deliveri servic via technolog explor aya experi need understand benefit challeng shift remot deliv servic
|
D000086382
|
T047;T067
|
36,311,610
|
health cadr empower program smartphon applic base educ video promot child growth develop indonesia health care system reli non health profession call cadr oper child health promot program public health center puskesma despit effort child malnutrit rate remain high studi aim identifi develop health promot media assist health cadr promot child health studi divid three phase first phase need assess use focus group discuss knowledg attitud practic kap second phase video develop involv medic student general practition pediatrician health promot expert third phase video view cadr post view test health cadr comparison pre test post test particip total score perform student test need assess show knowledg cadr need improv need proper educ media materi use puskesma five video produc four video children nutrit intak recommend four differ age group one video inform invit come integr health servic post posyandu signific improv pre test total score post test total score p smartphon applic base educ video effect reliabl child health promot media puskesma staff parent
|
D000068997;D013337
|
T073;T097
|
36,311,609
|
smokeless tobacco industri brand stretch fm radio studi delhi nation capit region india smokeless tobacco slt consumpt associ multipl advers health effect mortal highest burden india fctc ban tobacco advertis promot sponsorship via articl indian law also prohibit kind direct indirect advertis form audio visual print media brand promot sponsorship tobacco product howev tobacco industri continu find aggress market way advertis product studi aim assess extent surrog advertis smokeless tobacco product frequenc modul fm radio station citi delhi nation capit territori india studi advertis broadcast fm radio across differ channel privat govern own total h analyz time durat spread even morn peak hour hour even peak hour found multipl brand includ vimal kamla pasand rajshre use surrog advertis market brand common associ smokeless tobacco product howev advertis found air govern own fm channel total surrog advertis broadcast time signific differ found distribut among peak non peak hour studi indic tobacco industri make way sell product indirect advertis need hour enforc tobacco advertis ban law form advertis media also strict regul smokeless tobacco product
|
D014030;D019460;D062789
|
T121;T073;T109;T092;T131;T167
|
36,311,608
|
qualiti aspect relat give birth switzerland analysi qualiti indic inpati obstetr qualiti transpar support reduct inform asymmetri health care system enabl target regul health care studi examin qualiti variat inpati obstetr care use offici feder offic public health inpati qualiti indic ch iqi vagin birth rd th degre perin tear vagin birth episiotomi caesarean section low risk birth includ matern hospit birth birth perin lacer rd th degre switzerland perform poorer comparison germani iqi austria iqi birth episiotomi switzerland germani caesarean section rate low risk birth switzerland germani compar swiss clinic privat clinic locat particular stand one possibl reason may densiti care patient demand system affili physician clinic
|
D009774;D007744;D022125
|
T046;T091;T037
|
36,311,607
|
covid relat inform seek impact media parent concern expans inform sourc use acceler sinc begin covid pandem sometim provok signific concern daili live parent object studi investig associ covid relat inform sourc level concern covid among parent school age children use factor analysi hierarch ascend classif construct group accord inform sourc use perform anova analysi binomi logist regress compar concern level among group creat overal particip main women report year old mean concern score sampl sd whole sampl fell three group tradit media n main use newspap onlin social network entourag n most consult onlin social media well friend famili unplug n consult inform sourc compar unplug individu two group higher risk concern tradit media p social network entourag p communic pandem risk convey base reliabl inform moder interv safeguard mental health individu
|
D000086382;D061108
|
T047;T170;T067
|
36,311,606
|
effect grand multipar advers matern outcom prospect cohort studi grand multipar remain risk factor wide rang obstetr complic especi develop countri grand multipar shown increas risk medic obstetr complic pregnanc howev research set risk factor associ advers matern outcom yet adequ investig among grand multipar furthermor limit inform examin effect grand multipar pregnanc outcom ethiopia prospect follow design
|
D011256;D011295
|
T033;T058
|
36,311,605
|
psychometr properti chines version sugar sweeten beverag media literaci scale undergradu specif domain sugar sweeten media literaci scale ssm ml shown signific assess sugar sweeten beverag ssb calori intak us popul studi aim describ psychometr properti revis chines version ssb ml c ssb ml evalu valid reliabl result undergradu two largest univers provinc southwest china show cronbach alpha overal scale three dimens two halv analysi satisfactori criterion relat valid c ssb ml posit associ e health literaci scale eheal confirmatori factor analysi show three factor model c ssb ml adequ fit indic p standard root mean squar residu srmr root mean squar error approxim rmsea find provid evid valid reliabl tool use assess sugar sweeten media literaci chines undergradu help organ leverag media literaci strategi formul ensur ssb intak control much possibl effect effort front
|
D000080845
|
T168
|
36,311,604
|
epidemiolog characterist surviv analysi patient occup pneumoconiosi zhejiang provinc evalu risk factor affect surviv patient diagnos pneumoconiosi propos strategi improv qualiti life patient
|
D011788;D011009
|
T078;T047
|
36,311,603
|
use parthenium hysterophorus synthet chelat enhanc uptak cadmium lead contamin soil step toward better public health parthenium hysterophorus l vigor plant speci cosmopolitan distribut uptak consider quantiti heavi metal soil accru metal differ tissu use chelat agent ie ethylenediaminetetraacet acid edta boost metal uptak capac pot experi perform evalu phytoextract potenti p hysterophorus lead pb cadmium cd without aid edta chelat shoot length weight root shoot fresh dri leav number chlorophyl content p hysterophorus got reduc increas metal uptak result reveal highest concentr cd shoot without edta mg kg correspond increas pb concentr also boost edta maximum concentr shoot mg kg general pb cd concentr greater shoot p hysterophorus root regardless edta treatment edta also impact posit accumul essenti ion k na ca p hysterophorus capac p hysterophorus accumul pb cd found increas edta soil bring metal level soil accord standard improv ecosystem well public health
|
D002104;D012989
|
T131;T196
|
36,311,602
|
accept prepay social solidar cross subsidi nation health insur mix method studi western kenya mani low middl incom countri attempt financ healthcar voluntari membership insur scheme studi examin willing prepay health care social solidar well accept subsidi poor factor determin enrol western kenya
|
D007348;D009313
|
T058;T170
|
36,311,601
|
person school reopen spread sar cov second wave spain investig effect school reopen evolut covid infect second wave spain studi region age group variat within interrupt time seri design spain autonom communiti reopen school differ moment time septemb find person school reopen correl burst infect almost region data spanish region give leverag case pre secondari secondari educ start differ date analysi case allow conclud whether reopen one educ stage overal stronger impact provid plausibl mechan connect school reopen burst contagion studi catalan case detail scrutin interrupt time seri pattern infect among age group possibl connect stark sudden increas contagion among older children person school reopen appear drag evolut age group accord granger causal might taken indirect indic household transmiss offspr parent import societ implic aggreg dynam infect
|
D000086402;D000086382
|
T005;T067;T047
|
36,311,600
|
relationship social particip depress symptom among chines middl age older adult cross lag panel analysi studi examin mutual effect social particip depress symptom middl age older chines adult offlin onlin perspect reciproc relationship depress symptom four subtyp offlin particip also examin
|
D058992;D003863
|
T184;T054;T048
|
36,311,599
|
global preval epidemiolog trend hashimoto thyroid adult systemat review meta analysi although hashimoto thyroid associ cardiovascular diseas malign global status hashimoto thyroid well character across region object evalu preval trend hashimoto thyroid adult region differ econom incom level around world
|
D050031
|
T047
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.