PMID
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36,347,821
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local cooper cornerston facilit barrier resili decentr health system covid finland purpos studi elucid facilit barrier health system resili resili respons local region level first year covid pandem finland
|
D000086382
|
T047;T067
|
36,347,714
|
quantit space resolv situ epr imag detect metal lithium deposit abil monitor lithium deposit anod real time becom progress import due develop advanc anod technolog given fact detriment li deposit alway micron scale electron paramagnet reson epr happen effect select detect technolog due skin effect quantit situ epr imag carri magnet field gradient achiev one dimension spatial resolut along li growth direct capillari cell quantif li deposit care calibr use diphenyl picrylhydrazyl standard process method present correct doubl integr dysonian line metal li li deposit process compar two differ electrolyt electrolyt contain fluoroethylen carbon fec addit fit result dysonian line suggest plate li larger dimens microstructur strip proceed uniform thus account higher coulomb effici electrolyt fec situ epr imag also suggest sand capac vari electrolyt forc growth dendrit li carri larg current densiti use deriv operando epr method monitor growth locus li dendrit indic tip grow mechan work instruct engag studi electro deposit lithium use situ epr imag technolog
|
D008094;D002254
|
T121;T196;T109
|
36,347,705
|
magnet circular dichroism within algebra diagrammat construct scheme polar propag third order present implement b term magnet circular dichroism mcd within algebra diagrammat construct adc scheme polar propag intermedi state represent illustr result mcd spectra adc variant adc adc x adc molecular system uracil thiouracil thiouracil purin hypoxanthin naphthoquinon anthraquinon naphthylamin comput compar result obtain use resolut ident coupl cluster singl approxim doubl method literatur time depend densiti function theori result avail experiment data
|
D011789;D014498
|
T121;T123;T170;T114
|
36,347,700
|
bypass backmap coars grain electron properti distribut use heteroscedast gaussian process employ deep kernel learn electron coars grain dkl ecg approxim gaussian process flexibl scalabl framework learn heteroscedast electron properti distribut smooth function coars grain cg configur appropri gaussian prior predict cg properti distribut justifi function cg model resolut examin statist target distribut certainti predict cg distribut shown limit cg model resolut dkl ecg predict nois converg intrins physic nois induc cg map oper multipl chemistri analysi resolut depend learn cg properti distribut allow identif cg map oper captur cg degre freedom strong electron phonon coupl demonstr abil construct exact quantum chemic valenc electron densiti state edo includ behavior tail edo entir cg model combin iter boltzmann invers dkl ecg dkl ecg provid mean learn cg distribut atom properti tradit lost cg model develop introduc promis methodolog altern backmap algorithm common employ recov atom properti distribut cg simul
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D056004;D000465
|
T066;T170;T044
|
36,347,697
|
coupl charg energi transfer dynam light harvest complex hybrid hierarch equat motion approach describ method simul exciton dynam protein pigment complex includ effect charg transfer well fluoresc method combin hierarch equat motion use describ quantum dynam exciton nakajima zwanzig quantum master equat use describ slower charg transfer process studi charg transfer quench light harvest complex ii protein postul control non photochem quench mani plant speci use hybrid approach find good agreement calcul experiment measur excit lifetim furthermor calcul reveal exciton energi funnel play import role determin quench effici conclus expect extend protein perform protect excit quench also highlight need simul method proper account interplay exciton dynam charg transfer process
|
D010944;D045342
|
T123;T116;T002
|
36,347,691
|
impact electr field metal ion vibrat intern hydrogen bond strength alkali metal ion di triglycin complex use infrar predissoci spectroscopi cryogen ion revisit vibrat spectra alkali metal ion li na k di triglycin complex assign stabl conform involv metal ion coordin co group intern nhnh hydrogen bond peptid backbon analysi spectral shift oh co stretch vibrat across differ metal ion peptid chain length show larg caus electr field metal ion vari strength function squar distanc metal ion peptid interact also remot modul strength intern hydrogen bond peptid backbon via weaken amid co bond result decreas intern hydrogen bond strength li na k
|
D006859;D008672
|
T196
|
36,347,677
|
microrheolog thermosensit gell polym cell cultur investig rheo mechan properti mebiol gel thermosensit gel form polym extens use medium cellular cultur use passiv microrheolog made either standard dynam light scatter photon correl imag dilut limit mebiol display newtonian behavior effect viscos decreas temperatur consist peculiar aggreg mechan character increas molecular weight simultan reduct aggreg size increas concentr approach gelat storag loss moduli show nonmonoton depend temperatur pronounc maximum around c valu dilut limit individu mebiol chain fulli compact distinct trend elast viscous properti persist within gel therefor becom softer although temperatur chang perform adiabat transit fluid gel phase take place without appar discontinu rapid jump lead format hard gel concentr low heat rate convers yield fluid phase visibl manifest nonequilibrium natur physic gel
|
D011108;D018929
|
T104;T122;T059
|
36,347,675
|
spin vibron interact induc revers intersystem cross case studi txo tpa txo phcz molecul highlight import role direct spin orbit dso coupl spin vibron sv coupl dielectr constant medium play revers intersystem cross risc mechan txo tpa txo phcz molecul understand complex phenomenon calcul risc rate constant k risc use time depend correl function base method within framework second order perturb theori comput k risc two differ solvent toluen chloroform suggest addit dso dielectr medium depend sv mechan may also signific impact net enhanc rate risc lowest triplet state first excit singlet state wherea found k risc txo tpa most determin dso contribut independ choic solvent sv mechan contribut overal k risc txo phcz chloroform toluen howev sv mechan less import risc process txo phcz analysi mode specif nonadiabat coupl nac txo phcz txo tpa suggest nac valu certain normal mode txo phcz much higher txo tpa pronounc chloroform solvent find demonstr role solvent assist sv mechan toward net risc rate constant turn maxim effici thermal activ delay fluoresc
|
D011789;D002725
|
T131;T170;T130;T109
|
36,347,673
|
trimem parallel hybrid mont carlo softwar effici simul lipid membran lipid membran integr build block live cell perform multitud biolog function current molecular simul cellular scale membran remodel process atom resolut extrem difficult due size complex larg time scale process occur instead elast membran model use simul membran shape transit infer properti function unfortun effici parallel open sourc simul code lack present trimem parallel hybrid mont carlo simul engin triangul lipid membran kernel effici code c wrap python eas use parallel implement energi gradient calcul mont carlo flip move edg triangul membran enabl us simul larg high curv membran structur valid reproduc phase diagram vesicl vari surfac volum ratio area differ also comput densiti state verifi correct boltzmann sampl softwar use tackl rang larg scale membran remodel process step toward cell scale simul addit extens document make softwar access broad biophys comput cell biolog communiti
|
D012984;D008055
|
T090;T170;T073;T109
|
36,347,672
|
liganc effect nucleat kinet nucleat particl crystallin structur observ wide rang system metal metal organ compound colloid polymer patch particl perform kinet mont carlo simul studi nucleat kinet particl differ liganc z constant supersatur approach allow one determin sever physico chemic quantiti function includ growth probabl p n critic nucleus size n stationari nucleat rate j numer result ration term self consist nucleat theori n j present non trivial depend determin valu effect z depend paramet
|
D003460
|
T104;T070
|
36,347,669
|
modern view coher pathway appli magnet reson experi unstabl inhomogen field articl present standard altern tradit phase cycl approach employ overwhelm major contemporari nuclear magnet reson nmr research well test stabl nmr system run well test puls sequenc high optim homogen magnet field hardwar andor softwar respons tradit phase cycl quick isol meaning subset data averag discard digit data contrast new domain color coher transfer dcct approach enabl use inform acquir transient approach prove particular use multipl coher pathway requir improv signal magnet field inhomogen unstabl exampl author interest nanoscal heterogen hydrat dynam demand increas sophist autom measur deploy overhaus dynam nuclear polar odnp low field electromagnet phase cycl signal averag perform suboptim articl demonstr capabl dcct odnp data collect algorithm provid robust phase avoid baselin distort abil realiz relat weak signal amid background nois signal averag correl align dcct schema work combin multidimension organ phase cycl data specif methodolog visual result complex valu data could extend form coher spectroscopi seek analyz multipl coher transfer pathway
|
D008279;D000465
|
T060;T170;T059
|
36,347,666
|
photoelectron imag cryogen cool bio bio anion advent ion trap cool devic revolution ion spectroscopi possibl effici cool ion vibrate rotate level truli high resolut experi feasibl report first result new experiment apparatus coupl cryogen paul trap laser vapor cluster sourc high resolut photoelectron imag cold cluster anion demonstr abil new apparatus effici cool bio bio minim vibrat hot band allow high resolut photoelectron imag obtain electron affin bio bio measur accur first time ev respect vibrat frequenc ground state bio bio well anion determin temperatur depend studi report
|
D003080
|
T070
|
36,347,646
|
shape depend gold nanoparticl interact model cell membran customiz gold nanoparticl platform motiv innov drug discoveri massiv therapeut potenti due biocompat stabil imag capabl develop requir understand discret differ shape charg surfac chemistri affect drug deliveri process nanoparticl nanoparticl shape signific impact nanoparticl function exampl drastic chang surfac area avail modif surfac ligand densiti order investig effect nanoparticl shape structur cell membran direct probe nanoparticl lipid interact interfac sensit techniqu term sum frequenc generat sfg vibrat spectroscopi gold nanostar gold nanospher posit charg ligand allow interact model cell membran chang membran structur direct observ specif sfg vibrat mode relat molecular bond within lipid sfg result demonstr au nanostar penetr impact order lipid made membran littl structur chang model membran observ sfg au nanospher interact model membran suggest au nanostar compar au nanospher disrupt cell membran find indic import shape nanomateri design provid strong evid shape play role defin nanomateri biolog interact
|
D006046;D053768
|
T121;T196;T073
|
36,347,619
|
weight base protocol offer signific reduct radiat dose without affect pet ct imag qualiti investig use weight base protocol full half bodi fluorodeoxyglucos f fdg positron emiss tomographi comput tomographi pet ct effect imag qualiti radiat dose lifetim attribut risk
|
D000072078;D009381
|
T060;T191
|
36,347,612
|
effect lag time perform arrt primari certif registr exam investig lag time graduat educ program exam date influenc candid perform american registri radiolog technologist arrt certif registr exam radiographi nuclear medicin technolog radiat therapi magnet reson imag
|
D002568;D004521
|
T081;T064;T065
|
36,347,610
|
radiolog scienc student percept advis investig student percept structur advis program
|
D013334
|
T081;T098
|
36,347,587
|
research progress biomark nasal secret endotyp diagnosi clinic applic chronic rhinosinus develop studi endotyp chronic rhinosinus crs biomark nasal secret studi crs endotyp base nasal secret becom abund paper summar endotyp classif crs collect method nasal secret nasal secret biomark relat endotyp crs order provid refer establish correspond endotyp crs base nasal secret biomark
|
D012220;D012852;D009298
|
T047
|
36,347,586
|
clinic applic progress subject visual vertic test subject visual vertic test consid effect techniqu evalu otolith organ function central pathway graviti percept test non invas easi oper littl stimul present studi china paper review concept measur principl method influenc factor applic advantag disadvantag subject visual vertic test
|
D010037;D012444
|
T023
|
36,347,585
|
research progress botulinum toxin type treatment chronic rhiniti botulinum toxinbont superfamili neurotoxin produc bacterium clostridium botulinum disturb signal transmiss neuromuscular neuroglandular junction inhibit neurotransmitt releas presynapt nerv termin bont wide use neuromuscular hypersecretori autonom nerv system disord recent year botulinum toxin type abont use treat chronic rhiniti studi shown intranas administr bont safe effect reduc nasal symptom rhiniti patient long last effect articl review research progress bont treatment chronic rhiniti
|
D019274;D012220
|
T129;T121;T116;T109;T131;T047
|
36,347,584
|
case madelung diseas combin laryng cancer madelung diseas lipodystrophi unknown etiolog articl report case madelung diseas complic laryng cancer clinic manifest patient progress hoars dyspnea dysphagia diffus symmetr swell neck subment submandibular dynam laryngoscopi reveal giant cauliflow like neoplasm throat left vocal cord fix laryng ct show laryng carcinoma transglott type sign lymph node metastasi left jugular chain region madelung syndrom neck biochem test show albumin gl globulin gl prealbumin gl aspart aminotransferas iul transpeptidas iul alanin aminotransferas iul creatinin moll preoper patholog suggest squamous cell carcinoma admiss diagnosi includ laryng cancer transglott tnm degre laryng obstruct madelung diseas fatti liver patient recov well surgeri
|
D008069;D007822;D000402
|
T047;T191;T046
|
36,347,583
|
case mediastin bronchial cyst misdiagnos schwannoma case report case mediastin bronchial cyst misdiagnos schwannoma report patient chest pain dyspnea cough sputum hemoptysi past chest enhanc ct show mediastin mass clear boundari larger cross section cm cm obvious enhanc primari diagnosi consid schwannoma tracheal cyst esophagus cyst mediastin tumor resect via cervic approach general anesthesia oper found mass locat middl upper mediastinum diamet cm smooth surfac contain gelatin cystic fluid adher esophagus trachea postop patholog diagnosi bronchogen cyst patient recov well oper recur sinc follow
|
D008476;D001994;D009442
|
T019;T047;T191
|
36,347,582
|
effect bodi mass index efficaci reposit procedur horizont canal benign paroxysm posit vertigo object evalu effect bodi mass index bmi efficaci reposit procedur horizont canal benign paroxysm posit vertigo hc bppv method total patient diagnos hc bppv first affili hospit xian jiaotong univers school medicin jan oct enrol patient divid low bmi groupbmi kgm high bmi groupbmi kgm two group underw manual reposit procedur vertigo treatment system procedur barbecu method accord order visit two circl reposit influenc factor reposit analyz accord effici result effect rate manual reposit hc bppv patient effect rate vertigo treatment system effect rate vertigo treatment system reposit higher manual reposit p effect rate manual reposit low bmi group higher high bmi group p logist regress analysi suggest bmi influenc factor hc bppv reposit efficaci p conclus bmi affect efficaci hc bppv manual reposit vertigo treatment system hc bppv reduct better manual reduct efficaci affect bmi
|
D065635;D056888
|
T047;T058
|
36,347,581
|
effect age involv semicircular canal calor test patient primari horizont semicircular canal benign paroxysm posit vertigo object investig effect age involv semicircular canal result calor test patient primari horizont semicircular canal benign paroxysm posit vertigobppv method total patient conform diagnosi primari horizont semicircular canal bppv select case group anoth non bppv patient dizzinessvertigo main complaint select control group group divid elder group young middl age group accord age general inform result calor test compar analyz group result statist signific differ gender composit type involv semicircular canal differ age group p patient horizont semicircular canal canalolithiasi statist signific differ rate abnorm calor test result differ age group p patient horizont semicircular canal cupulolithiasi statist signific differ rate abnorm calor test result differ age group p control group statist signific differ rate abnorm calor test result differ age group p conclus involv semicircular canal affect result calor test age affect result especi bppv patient horizont semicircular canal cupulolithiasi
|
D065635;D002150
|
T060;T047
|
36,347,580
|
diagnost valu comput tomograph cisternographi magnet reson hydrographi cerebrospin fluid rhinorrhea object evalu accuraci preoper comput tomograph cisternographyctc magnet reson hydrographymrhin diagnosi cerebrospin fluidcsf rhinorrhea method retrospect analysi made data patient diagnos cerebrospin rhinorrhea complet preoper hrct ctc mrh examin depart otolaryngolog head neck surgeri tianjin huanhu hospit octob januari diagnost accuraci preoper imag examin compar accord leak locat found oper result among case csf rhinorrhea detect rate hrct ctc cranial mrh respect accuraci ctc significantlyhigh mrh p accuraci mrh signific higher hrct p subgroup analys perform accord precis posit cerebrospin fluid rhinorrhea leakag patient cerebrospin fluid rhinorrhea locat ethmoid sinus accuraci ctc vs p mrh vs p signific higher hrct accuraci differ ctc mrh ctc mrh statist signific p accuraci ctc signific higher mrh vs p hrct vs p patient csf rhinorrhea locat sphenoid sinus howev signific differ accuraci mrh hrct p howev signific differ accuraci ctc mrh hrct patient cerebrospin fluid rhinorrhea locat frontal sinus accuraci ctc mrh respect patient fail detect csf rhinorrhea hrct differ statist signific p conclus comprehens applic multipl imag method import guid signific accur treatment prognosi evalu ctc mrh could improv accuraci local diagnosi cerebrospin fluid rhinorrhea
|
D002559
|
T047;T037
|
36,347,579
|
correl video head impuls test paramet dhi score patient vestibular neuriti object explor correl paramet video head impuls test vhitand dizzi handicap inventori dhi score patient vestibular neuriti method clinic data patient vestibular neuriti retrospect analyz patient underw dhi evalu vhit examin divid mild handicap group moder handicap group sever handicap group accord dhi score correl paramet vhit dhi score compar among three group import paramet vhit compar includ vestibulo ocular reflex vor gain gain asymmetri ratio ga abnorm saccad dispers pr result patient mild handicap group moder handicap group sever handicap group comparison mean valu later semicircular canal vor gain vhit gain patient mild moder sever handicap respect mean valu vor gain negat correl dhi score among three group r p pairwis comparison among three group statist signific p comparison mean pr later semicircular canal mean pr patient mild moder sever handicap group respect pr posit correl dhi score r p comparison among three group statist signific p vertic semicircular canal vhit gain patient mild moder sever handicap respect mean vor gain negat correl dhi score among three group r p comparison mild sever moder sever group statist signific p pr patient mild moder sever handicap respect posit signific correl pr dhi score r p statist signific comparison mild sever group p conclus vor gain pr valu vhit patient vestibular neuriti close relat dhi score evalu vestibular function degre vertigo
|
D064087;D020338
|
T060;T047
|
36,347,578
|
clinic analysi case pediatr nasal dermal sinus cyst midfaci infect first symptom object review clinic radiolog present manag infect nasal dermal sinus cystsndsc children method clinic data collect ndsc children secondari fronto orbit area infect present beij children hospit januari decemb patient underw preoper imag workup includ mri ct patient underw endoscop excis ndsc general anesthesia result total patient includ studi present sinus present cystth main lesion ndsc includ nasal root case nasal bridg case nasal tip case nasal tip nasal root case depth lesion includ case superfici type nasal frontal bone case nasal frontal bone case intracrani epidur type case intracrani epidur type main site infect includ inner canthus case nasal dorsum case nasal root case forehead case among case case complic diseas case extern nasal deform surgic approach includ transvers incis case minim midlin vertic incis case extern rhinoplasti case bicoron incis vertic incis case rang lesion complet consist mri resultsal case success oper without one stage nasal dorsum reconstruct patient follow monthsaverag month case recurr situ recurr oper perform recurr occur sinc follow nasal deform note cosmet outcom favor patient conclus ndsc infect children midfaci infect first symptom rare clinic practic manifest divers earli diagnosi ration treatment import improv cure ratepreop high resolut mri combin ct scan great signific judg cours ndsc especi intracrani extens treatment goal achiev minim invas individu treatment premis complet excis lesion take account cosmet need
|
D003884;D009669;D016136;D010254;D012225
|
T061;T019;T047;T191
|
36,347,577
|
effect endonas endoscop dacryocystorhinostomi combin lacrim duct drainag tube implant treat lacrim duct obstruct object investig clinic effect endonas endoscop dacryocystorhinostomye dcr combin lacrim duct drainag tube implant treat patient lacrim duct obstruct method patient eye lacrim duct obstruct includ studi includ patient eye function nasal lacrim duct obstruct patient eye recurr ee dcr patient eye nasal lacrim duct obstruct patient eye small lacrim sac patient eye lacrim duct obstruct intraop ee dcr perform lacrim drainag tube implant upper lower lacrim point septoplasti perform patient nasal septum deviat endoscop sinus surgeri perform patient chronic sinusitisaft oper nasal hormon spray perform follow oper effect evalu accord degre symptom improv patenc lacrim passag irrig open state dacryocystorhinostomi nasal endoscop result month follow case eye cure case eye improv case eye ineffect total effect rate intraorbit intracrani nasal complic occur patient conclus ee dcr combin lacrim duct drainag tube implant safe effect treat lacrim duct obstruct implant lacrim duct drainag tube effect avoid stoma blockag prevent adhes lacrim duct signific improv success rate surgeri
|
D003608;D007767;D007765;D009301
|
T061;T033;T023;T030
|
36,347,576
|
relationship imag featur intraop perilymph gusher patient mondini inner ear malform object investig relationship imag characterist intraop perilymph gusher patient mondini inner ear malform cochlear implant order provid basi clinic guidanc predict intraop perilymph gusher cochlear implant method accord sennaroglu classif method children sever sensorineur hear loss screen januari decemb divid mondini group simpl enlarg vestibular aqueduct group normal inner ear group accord inclus criteria strict imag tempor bone hrct inner ear mri post process relat indic measur includ cochlear height width vestibular aqueduct etc gusher situat cochlear implant record mean valu indic among three group compar respect differ indic gusher group non gusher group analyz result statist signific differ cochlear height length cochlear bottom turn width cochlear apertur vestibular length vestibular width among mondini group case simpl eva group case normal inner ear group case incid gusher mondini group cochlear implant outer diamet va mm middl width va mm gusher group wider non gusher group differ statist signific incid intraop gusher patient eva statist signific differ length endolymph sac gusher group non gusher group p conclus caus intraop perilymph gusher patient mondini inner ear malform complex enlarg vestibular aqueduct may one anatom basi whether use guid preoper assess risk intraop perilymph gusher need confirm larg sampl clinic research multipl center futur
|
D006319;D014723;D019929;D014722
|
T061;T047;T023
|
36,347,575
|
sensit characterist cockroach beij area object investig sensit characterist cockroach patient allerg rhinitisar andor allerg asthma beij area provid basi prevent treatment cockroach sensit popul method clinic data patient allerg rhiniti andor asthma januari decemb treat outpati depart allergi beij shijitan hospit retrospect analyzedskin prick test spt perform cockroach allergen reagent cockroach sensit patient differ age diseas compar popul distribut characterist cockroach sensit observedstatist analysi perform use sas softwar result total patient enrol endth total posit rate cockroach spt highest posit rate year old group posit rate spt increas age patient less year old posit rate spt basic flat age patient year old posit rate cockroach spt allerg rhiniti patient allerg asthma patient allerg rhiniti combin asthma patient singl cockroach spt posit account cockroach indoor inhal allergen spt posit account posit spt rate combin der f der p hous dust cat dander dog dander respectivelyin allerg rhinitisasthmaand allerg rhiniti combin asthmath cockroach spt posit rate higher adult group juvenil groupand differ posit rate allerg rhiniti group statist signific vs p juvenil group posit rate spt ar combin asthma higher ar asthma conclus cockroach allergi patient ar andor allerg asthma beij relat high sensit multipl inhal allergen sensit degre adult higher juvenil
|
D003058;D065631;D001249
|
T047;T204
|
36,347,574
|
multifactori analysi degre hear loss outcom patient sudden hear loss object investig relationship sever curat effect hear loss clinic indic patient sudden hear loss shl method spearman correl coeffici use analyz correl efficaci shl clinic indicatorsa total two hundr seventi three patient shl select divid three quantil group accord averag hear threshold involv ear frequenc first pure tone audiometri admiss univari multivari order logist regress use evalu relationship initi hear level clinic indic shl patient spearman correl coeffici use analyz correl efficaci shl clinic indic result compar patient lower hear loss db hlpatient higher hear loss db hl higher neutrophil monocyt triglycerid hemoglobin fibrinogen glucos neutrophilhigh densiti lipoprotein cholesterol ratio nhr monocytehigh densiti lipoprotein cholesterol ratio monocytelymphocyt cell ratio age dizzi lower platelet lymphocyt cell ratio high densiti lipoprotein cholesterol poor final hear thresholdmultivari logist regress show nhr age independ risk factor initi hear loss shl patientsand nhr neutrophillymphocyt cell ratio nlr cours diseas type hear curv final hear threshold signific negat correl curat effect conclus shl patient higher nhr nlr valu longer time onset visit sever hear loss wors efficacyhowev shl patient higher nhr age valu greater initi hear loss degre hear loss curat effect differ shl patient differ type hear threshold curv age
|
D003639;D003638;D006319
|
T033;T184;T047
|
36,347,573
|
reoper treatment persist postop secondari hyperparathyroid object evalu clinic effect reoper persist hyperparathyroid phpt patient oper parathyroidectomi combin autotransplantationptxat secondari hyperparathyroid shpt method phpt patient treat reoper ptxat enrol studi period aug dec depart otolaryngolog head neck surgeri peke univers civil aviat school clinic medicin civil aviat general hospit remain parathyroid gland locat preoper colour doppler ultrasonographi radionuclid imag enhanc ct mr imag neck region base imag find remain parathyroid gland remov situ miss ectop extra parathyroid gland resect extend surgic scope accord parathyroid dissect method surgic effect evalu chang clinic symptom dynam chang serum intact paramyroidhomonei pth preoper postop period surgic complic result patient accept success oper parathyroid gland resect confirm postop patholog includ situ ectop gland superior mediastinum thymus posterior mediastinum thyroid gland carotid sheathosteoarthropathi skin itch signific reliev even disappear h surgeri level serum pth calcium phosphorus reach standard muscl weak signific improv week surgeri patient present hypocalcemia return normal supplement calcium hoars due temporari injuri laryng nerv found case serious complic death occur operationther recurr year follow conclus reoper first choic shpt patient complic persist hyperparathyroid multipl imag examin use locat residu parathyroid especi ectop gland expand surgic scope appli resect residu parathyroid glandsectop situ conceal parathyroid accord concept dissect parathyroidectomi surgeri effect safe patientsqu life long term surviv rate improv
|
D002118;D006962
|
T123;T196;T121;T047
|
36,347,572
|
chang subject visual vertic otolith reduct patient bppv object observ analyz chang subject visual verticalsvv otolith reduct patient bppv method patient confirm bppv reciev success otolith reduct select test group case posterior canal stone case horizont semicircular canal stone case right ear case left ear fifti case healthi young volunt control group use virtual realiti svv examin system svv posit head test test group patient reduct svv test control group deviat angl svv otolith reduct test group analyz result otolith reduct svv right bppv left bppv otolith reduct svv right bppv left bppv control group svv chang svv deflect angl control group right bppv otolith reduct otolith reduct right bppv analyz differ statist signific signific differ svv deflect angl left bppvbefor reduct control group test group otolith reduct case larger bias angl case smaller bias angl among case deviat angl even turn contralater side conclus utricular dysfunct patient bppv lead judgment error svv reduct otolithoid caus new stimul eutricul affect function status svv detect provid help evalu utricular function patient bppv
|
D010037;D012665
|
T023
|
36,347,571
|
interpret consensus mri endolymphat hydrop patient suspect hydrop ear diseas domest research progress endolymphat hydropseh consid histolog hallmark menier diseas visual eh achiev special sequenc inner ear magnet reson imagingmri gadolinium base contrast agent via intraven intratympan administr although appli ten year sinc unifi view techniqu yet achiev yang jun duan maoli et al led organ write intern expert consensus mri eh articl interpret main content report relat progress
|
D018159;D008575
|
T047
|
36,347,562
|
secondari caus elev hemoglobin patient undergo molecular test suspect polycythemia vera southwestern ontario chart review molecular test jak mutat part standard diagnost workup patient suspect polycythemia vera sought character evolv practic pattern investig erythrocytosi preval secondari caus includ use medic sodium glucos cotransport sglt inhibitor among patient underw molecular test
|
D011087;D011086;D000077203
|
T121;T109;T191;T033;T047
|
36,347,561
|
salivari test sar cov pediatr popul diagnost accuraci studi accur time test sar cov pediatr popul crucial control covid pandem saliva test propos less invas altern nasopharyng swab sought compar detect sar cov use saliva versus nasopharyng swab pediatr popul determin optimum time test sar cov use saliva
|
D000086402;D000086382
|
T005;T067;T047
|
36,347,560
|
continu physician care last year life differ caus death categori retrospect popul base studi mix care provid famili physician specialist palliat care physician vari ill lead death may result disrupt continu care end life measur continu outpati physician care last year life across differ caus death assess factor associ higher continu
|
D013727;D009369
|
T058;T191
|
36,347,559
|
tfiih moonlight telomer although telomer essenti chromosom stabil repres fragil structur genom telomer shorten occur age cell lack telomeras due end replic problem addit recent work uncov bulk telomer dna pose sever hurdl semiconserv dna replic machineri requir assist increas number special factor prevent accident telomer loss damag event issu gene develop yang colleagu pp discov tfiih basic compon polii transcript initi nucleotid excis repair machineri facilit telomer replic tfiih recruit telomer shelterin compon trf take telomer moonlight function
|
D035321;D019098
|
T123;T126;T116
|
36,347,558
|
tribe stamp reveal new insight function rna bind protein rna bind protein rbps import player rna metabol gene regul issu gene develop flamand colleagu pp develop new method tribe stamp detect bind event two distinct rbps singl mrna molecul first appli ythdf famili n methyladenosin reader protein investig show rbps larg share common pool bound transcript individu mrna may bound multipl ythdf protein throughout lifetim singl molecul techniqu excit new method studi potenti synergi andor antagon differ rbps
|
D016601;D005786
|
T045;T123;T116
|
36,347,556
|
comparison amikacin fosfomycin add ciprofloxacin antibiot prophylaxi transrect prostat biopsi singl center retrospect studi assess effect ciprofloxacin cp fosfomycin compar cp amikacin patient fluoroquinolon fq resist rectal flora undergon transrect ultrasound guid prostat biopsi truspb
|
D005578
|
T195;T109
|
36,347,555
|
clinic benefit retrograd bladder fill method prior cathet remov turp bph prospect random trial evalu possibl benefit clinic feasibl retrograd bladder fill method prior intra vesic cathet remov transurethr prostatectomi turp benign prostat hyperplasia bph
|
D020728;D011470
|
T061;T047;T191
|
36,347,554
|
use ergonom new robot system flexibl ureteroscopi laser lithotripsi treat renal stone investig use ergonom newli develop robot system flexibl ureteroscopi easyuretero
|
D017602;D065287;D007669
|
T061;T047
|
36,347,553
|
modifi apic dissect improv earli contin robot assist laparoscop radic prostatectomi compar studi modifi apic dissect anterior suspens stitch recent modifi apic dissect mad techniqu robot assist laparoscop radic prostatectomi rarp shown excel function outcom never rigor valid various institut studi aim evalu effect mad earli contin potenc compar anterior suspens stitch ss techniqu
|
D012371;D014549;D065287;D010535
|
T061;T090;T060;T046
|
36,347,552
|
prostat health index multi parametr mri improv diagnost accuraci detect prostat cancer asian popul aim studi evalu effect prostat health index phi prostat multi parametr magnet reson imag mpmri predict prostat cancer pca clinic signific prostat cancer cspca initi prostat biopsi
|
D000081364;D011471
|
T060;T191
|
36,347,551
|
prognost valu endotheli activ stress index patient upper tract urotheli cancer undergo radic nephroureterectomi relationship endotheli activ stress index easix repres degre endotheli dysfunct unwel known upper tract urotheli carcinoma utuc present studi aim assess prognost valu easix recurr free surviv rfs overal surviv os patient utuc underw radic nephroureterectomi rnu
|
D002295;D001749
|
T191
|
36,347,550
|
comparison function oncolog outcom uterus spare radic cystectomi standard radic cystectomi femal retrospect studi studi aim compar function oncolog outcom femal underw uterus spare radic cystectomi usrc standard radic cystectomi src
|
D015653;D001749
|
T061;T191
|
36,347,549
|
retrospect singl center comprehens target genet sequenc analysi prognost surviv use tissu korean patient metastat renal cell carcinoma target therapi identifi candid gene mutat signific predict risk surviv prognosi treatment system first line target therapi tt metastat renal cell carcinoma mrcc patient
|
D002292;D007680
|
T191
|
36,347,548
|
best manag biochem failur radic prostatectomi biochem recurr bcr common radic prostatectomi effect treatment option men bcr curat treatment remain controversi although prostat specif antigen wide use surrog marker prostat cancer surviv fulli differenti prostat cancer specif surviv overal surviv thus challeng physician determin time treatment halt slow clinic progress diseas patient bcr avoid overtreat patient whose diseas may progress beyond bcr adjuv therapi radic prostatectomi radiotherapi intermedi high risk local prostat cancer benefit term diseas progress surviv recommend low risk prostat cancer signific advers effect relat radiotherapi androgen depriv therapi adt salvag radiotherapi srt also recommend patient bcr radic prostatectomi sever option manag bcr radic prostatectomi includ srt prostat bed andor pelvi continu intermitt adt observ patient comorbid prefer cancer relat factor must consid decid best manag strategi modern imag technolog positron emiss tomographi imag prostat specif membran antigen posit region enabl earlier detect diseas progress thus enhanc decis make futur diseas manag
|
D011467;D011471
|
T023;T191
|
36,347,545
|
lack peroxisom catalas affect heat shock respons caenorhabd elegan exact mechan heat shock induc lifespan extens although document across speci still well understood show fulli function peroxisom specif peroxisom catalas need activ canon heat shock respons heat induc hormesi caenorhabd elegan although heat shock hsp chaperon strong regul wt absenc peroxisom catalas ctl ua ii small heat shock protein display modest increas express mutant nuclear foci format hsf reduc ctl ua ii mutant addit heat induc lifespan extens observ wt absent ctl ua ii strain activ antioxid respons pentos phosphat pathway promin chang observ heat shock wt worm ctl ua ii mutant involv peroxisom cell wide cellular respons transient heat shock report give new insight role organell communic organ stress respons
|
D017173;D029742
|
T116;T204
|
36,347,544
|
c u rna deamin drive forc acceler sar cov evolut understand molecular mechan under rampant mutat sar cov would help us control covid pandem apobec mediat c u deamin major mutat type sar cov genom howev unclear whether novel mutat rate u higher c u mutat type detail drive forc analyz time cours sar cov global popul data found c u highest novel mutat rate u among mutat type u still increas time u novel c u event rather mutat type prefer particular genom region less local rna structur correl high novel c u mutat rate cascad model nice explain u c u deamin sar cov rna structur serv molecular basi extrem high continu acceler c u deamin rate mechan drive forc mutat adapt evolut sar cov find help us understand dynam evolut virus mutat rate
|
D000086402;D000086382
|
T005;T067;T047
|
36,347,536
|
implement result face valid consult relat empathi measur canadian depart surgeri consult relat empathi care measur valid questionnair design assess patient percept physician communic skill empathi use assess empathi medic specialti seldom appli surgeri assess empathi communic skill among group surgeon within singl academ institut
|
D004645;D010817
|
T055;T054
|
36,347,535
|
evalu tier oper room strategi academ centr compar high effici convent oper room wait time mani elect orthoped surgic procedur ontario becom unaccept long substanti exceed recommend guidelin consequ mani patient experi chronic pain disabl poor health outcom purpos studi test novel resourc save redesign outpati oper room servic base tier group surgic case maxim health benefit patient improv effici decreas wait time
|
D009873;D017558
|
T061;T073;T093
|
36,347,531
|
develop extern valid risk predict model fall patient indic antihypertens treatment retrospect cohort studi develop extern valid stratifi treatment multi morbid frail elder stratifi fall clinic predict model identifi risk hospit admiss death fall patient indic antihypertens treatment
|
D000959;D015233
|
T081;T121;T170
|
36,347,247
|
financi consider fulli virtual interview season cera studi famili medicin resid program director covid pandem led institut virtual interview near famili medicin resid program paradigm shift challeng perspect famili medicin program director across unit state part financi impact oper mani resid program sought investig program director opinion interview season well whether futur interview season plan would influenc financi outcom season
|
D007396;D000086382
|
T065;T047;T067;T097
|
36,347,241
|
combinatori antagonist effect tubulin glutamyl glycyl katanin microtubul sever microtubul spatiotempor complex posttransl modif pattern cell interpret tubulin modif code larg unknown show c elegan katanin microtubul sever aaa atpas mutat microcephali critic cell divis axon elong cilia biogenesi respond precis differenti combinatori three chemic distinct tubulin modif glycyl glutamyl tyrosin insensit acetyl glutamyl glycyl antagonist rheostat glycyl protect microtubul sever katanin exhibit grade diverg respons glutamyl tubulin tail act combinatori katanin hexam central pore constrain polyglutam chain pattern tail recogn product element distal katanin aaa core sens tubulin tyrosin detyrosin downregul sever multival microtubul recognit enabl katanin read multipl tubulin modif input explain vivo observ illustr effector integr tubulin code signal produc divers function outcom
|
D014404;D017173
|
T123;T116;T204
|
36,347,240
|
scribblecdeprac pathway control follow cell crawl cluster cohes collect border cell migrat collect cell movement drive normal develop metastasi drosophila border cell move cluster cell role rac gtpase migrat first establish border cell migratori cell rac stimul lead edg protrus upstream rac regul leader identifi howev regul function rac follow border cell unknown show border cell requir rac promot follow cell motil import cluster compact movement identifi rac guanin nucleotid exchang factor cdep also regul follow cell movement cluster cohes scribbl disc larg lethal giant larva local cdep basolater share phenotyp cdep reloc cdep gfp partial rescu scribbl knockdown suggest cdep major downstream effector basolater protein thus scribcdeprac pathway promot cell crawl coordin collect migrat vivo
|
D004330;D029721
|
T123;T116;T204
|
36,347,239
|
platr earli embryon lncrna exert function downstream cardiogen mesoderm lineag commit mammalian genom encod thousand long non code rnas lncrnas mani development regul differenti express across tissu suggest potenti role cellular differenti despit express pattern littl known lncrnas influenc lineag commit molecular level demonstr perturb embryon stem cellear embryon lncrna pluripot associ transcript platr direct influenc specif cardiac mesoderm lineag differenti show platr act molecular scaffold chaperon interact hippo signal pathway molecul yap tead regul express downstream target gene ctgf crucial cardiac lineag program import platr knockout mice exhibit myocardi atrophi valv mucin degener associ reduc cardiac output sudden heart failur togeth find provid evid platr requir cardiac lineag specif adult heart function mice
|
D062085
|
T123;T114
|
36,347,238
|
hitchhik guid across waddington landscap melanoma melanoma evolut may recapitul embryon develop progenitor tissu neural crest nc exact process unclear recent issu natur karra et al demonstr melanoma expans mirror hierarch process nc differenti generat cell subpopul distinct function includ growth metastasi
|
D008545
|
T191
|
36,347,237
|
twist pitx regul gut loop asymmetr express transcript factor pitx import correct asymmetri organ develop recent issu scienc sanketi et al find pitx express direct gut tilt independ nodal act brake counteract bmp signal right
|
D018398;D018507
|
T045;T123;T116
|
36,347,236
|
evolut diverg trajectori predat origin anim fungi anim fungi closest protist relat compris clade opisthokonta although compar close relat anim fungi diverg great one anoth new studi demonstr genom featur characterist anim fungi aros even origin two kingdom
|
D019143;D005658
|
T004;T038
|
36,347,235
|
natur select fair weather cooper impress long term studi greater ani bird reveal fluctuat select group size wet year abund food larger group enjoy greater protect predat dri year howev larger group suffer greater nestl mortal relat smaller group
|
D014887;D001717
|
T070;T012
|
36,347,234
|
decis make dopaminerg neuron better wors anim constant need weigh option base new experi someth initi consid bad becom better light someth wors new studi show fli evalu better wors
|
D059290;D003657
|
T025;T041
|
36,347,233
|
meiosi deciph dialog recombin synaptonem complex meiotic specif structur synaptonem complex regul meiotic recombin languag use regul yet fulli decod new studi identifi novel phosphoryl site synaptonem complex regul dna repair pathway choic reveal new corner rosetta stone meiosi
|
D013573;D011995
|
T026;T045
|
36,347,232
|
vitellogenesi evolutionari origin nutrient uptak anim evolutionari origin nutrient traffick key develop metazoan relat unexplor new studi model sea anemon exploit click chemistri gene edit provid insight nutrient traffick may arisen
|
D014818;D012615
|
T204;T042
|
36,347,231
|
neurosci action histori orbitofront cortex decis often made absenc instruct cue base instead memori previous action outcom new studi shed light orbitofront cortex track action histori adjust action time
|
D012201;D017397
|
T023;T029;T041;T030
|
36,347,230
|
target secret myosin v deliv vesicl formin condens secretori vesicl often deliv specif target like pre synapt termin cell tip focus exocytosi new work suggest biomolecular condens focus actin filament deliv incom vesicl condens plasma membran
|
D024701
|
T126;T116
|
36,347,229
|
neurodevelop maintain function circuit reconfigur neural circuit chang develop follow experi ad neuron rewir connect map process technic daunt new studi trace matur entir circuit subcellular detail reveal continu function gradual structur chang
|
D009474
|
T025
|
36,347,228
|
mental object rotat base two dimension visual represent discoveri mental rotat one signific landmark experiment psycholog lead ongo assumpt visual compar object differ three dimension viewpoint use explicit intern simul object rotat mental adjust one object match rotat thought perform three dimension represent object liter analog physic rotat particular thought imagin object continu adjust constant three dimension angular rotat rate initi orient final orient interven viewpoint qualit theori tri account phenomenon date explicit imag comput model under process result quantit account object viewpoint appear similar one anoth other three dimension angular differ reason specif pattern non uniform percept viewpoint reveal visual comput under mental rotat therefor compar human viewpoint percept model base kind two dimension optic flow comput thought underli motion percept biolog vision find model reproduc specif error particip make suggest mental rotat involv simul two dimension retin imag chang would occur rotat object compar object distal three dimension represent previous assum measur much proxim stimulus would chang watch object rotat captur perspectiv appear chang
|
D009039;D057849
|
T040;T041
|
36,347,227
|
undetect low frequenc sound increas danc live concert low frequenc sound bass make peopl danc music make peopl want move tend low frequenc sound bass instrument typic provid music puls peopl danc low pitch confer advantag percept movement time elicit stronger neural respons time compar high pitch suggest superior sensorimotor communic low frequenc sound process via vibrotactil vestibular addit auditori pathway stimul non auditori modal context music increas rate groov pleasur urg move music modul music rhythm percept anecdot account describ intens physic psycholog effect low frequenc especi electron danc music possibl reflect effect physiolog arous howev know associ extend direct causal effect low frequenc complex real world social context like danc concert low frequenc conscious detect affect behaviour test whether non auditori low frequenc stimul would increas audienc danc turn low frequenc vlf speaker live electron music concert measur audienc member movement use motion captur movement increas vlfs present vlfs near auditori threshold subsequ experi suggest undetect believ repres unconsci effect behaviour possibl via vestibular andor tactil process
|
D003615;D009146
|
T056;T170
|
36,347,226
|
gene shape leaf develop evolut plant leav display tremend variat shape discuss inform obtain genet live imag comput model help conceptu way gene activ translat differ leaf shape framework action gene leaf form captur sum effect amount durat direct cellular growth togeth produc leaf geometri use three differ exampl illustr point first emerg complex versus simpl leav eudicot aris differ organ wide growth durat well local growth repress leaf margin second develop strap shape grass leav broad sheath base versus typic eudicot leav narrow petiol featur grass leav emerg later expans zone leaf progenitor cell coupl later remodel growth earli domain leaf blade third format insect trap carnivor plant aros constrain direct growth produc deform exampl chang gene express differ class homeobox gene contribut alter growth pattern under differ aspect leaf shape divers
|
D018515;D005801
|
T028;T002
|
36,347,224
|
evolut human step count associ risk chronic diseas walk human fundament form moder intens physic activ associ reduc risk morbid mortal evolutionari perspect contribut much understand effect walk physic activ health howev know compar littl step count step taken per day chang cours human evolut potenti affect select oper physiolog respons moder intens physic activ influenc morbid mortal compar step count across human closest live relat great ape compil data epidemiolog compar physiolog show step count tripl human evolut potenti link higher level moder intens physic activ reduc morbid mortal highlight recent decreas step count evolutionari mismatch rais hypothesi dose respons relationship moder intens physic activ health shift human requir step per day promot extend healthspan lifespan
|
D016138;D015444
|
T061;T056;T169
|
36,347,223
|
paul e turner interview paul e turner yale univers studi evolutionari genet microb
|
D005075
|
T045
|
36,347,060
|
prevent diagnos hiv relat comorbid adolesc adolesc hiv grow adulthood risk comorbid comorbid adolesc often go unrecogn increas morbid mortal contribut poorer outcom youth hiv youth perinat nonperinat acquir hiv risk develop hiv associ non hiv comorbid includ cardiovascular diseas diabet mental health disord renal diseas bone disord youth hiv also risk alter fat distribut weight gain associ certain class antiretrovir therapi sexual transmit infect inconsist condom use pose sexual health challeng youth hiv prompt intervent comprehens histori take physic exam regular screen prevent treatment clinic evid comorbid condit need prevent progress complic
|
D015658;D012749
|
T047
|
36,347,059
|
croi tuberculosi infecti complic person hiv earli treatment anal high grade squamous intraepitheli lesion compar activ monitor reduc risk anal cancer person hiv landmark random trial particip multi countri random trial entir oral combin regimen consist bedaquilin pretomanid linezolid moxifloxacin week outperform world health organ recommend week standard care regimen multidrug resist tuberculosi tb usher new era shorter multidrug resist tb treatment studi tb coinfect person hiv present confer retrovirus opportunist infect pro vide new insight summar herein
|
D015658;D018088;D014376
|
T047
|
36,347,058
|
croi metabol complic hiv infect covid comorbid condit major impact health qualiti life surviv peopl hiv particular popul age confer retrovirus opportunist infect croi featur excel scienc relat specif comorbid cardiovascular diseas type diabet cancer frailti role system inflamm pathogenesi cardiovascular diseas import theme strong evid regard impact microbi transloc studi examin function impair frailti potenti import contributor concomit medic sleep disturb anchor anal cancerhigh grade squamous intraepitheli lesion outcom research studi provid crucial evid treatment high risk anal lesion reduc incid anal cancer import implic prevent devast comorbid addit numer present demonstr import comorbid condit covid outcom peopl hiv describ persist symptom acut sar cov infect resolv review focus abstract present croi area highlight clinic impact
|
D015658;D000086382;D002318;D000073496;D003924;D001005
|
T184;T067;T191;T033;T047;T046
|
36,347,057
|
croi advanc antivir therapi hiv covid viral hepat confer retrovirus opportunist infect provid rich sourc new data comprehens review antivir therapi covid intramuscular sotrovimab noninferior intraven sotrovimab serostatus predict efficaci sotrovimab molnupiravir appear safe modest effect decreas hospit rate trial low middl incom countri provid data support transit first line therapi without virolog suppress virolog suppress second line therapi dolutegravir base regimen addit data support use lenacapavir long act antiretrovir drug data across unit state demonstr negat impact covid pandem hiv care continuum although enhanc outreach effort decentr antiretrovir therapi deliveri associ improv care engag outcom research describ potenti mechan emerg integras strand transfer inhibitor resist studi provir genotyp high light limit use predict clinic signific resist sever studi look epidemiolog treatment hepat c b status current hepat c virus elimin effort data present hiv covid matern pediatr health includ year virolog outcom data earli antiretrovir therapi potenti reduc latent hiv reservoir infant hiv data present covid hiv therapeut children includ sar cov neutral monoclon antibodi children younger year age remdesivir hospit infant children long act therapi hiv treatment children
|
D015658;D000086382;D015497;D006525
|
T047;T005;T067
|
36,347,056
|
croi neurolog complic hiv sar cov pathogen confer retrovirus opportunist infect featur new import find neurolog complic hiv covid infect long term analys identifi cognit declin time phenotyp age stroke associ various comorbid peopl hiv neuroimag studi show greater neuroinflamm white matter damag demyelin overal brain age peopl chronic hiv infect childhood trauma exposur environment pollut contribut neuroimag find studi blood cerebrospin fluid biomark show system inflamm neurodegener endotheli activ oxid stress iron dysregul associ wors cognit peopl hiv anim studi focus myeloid cell central nervous system anim human studi show lymphoid cell also contribut hiv neuropathogenesi deleteri central nervous system effect polypharmaci anticholinerg drug peopl hiv demonstr contrast larg random control trial show integras strand transfer inhibitor therapi associ neurotox studi cryptococc mening demonstr cost effect singl high dose liposom amphotericin prognost valu cryptococc antigen later flow assay peopl hospit covid anxieti time discharg sar cov nucleocapsid antigen present cerebrospin fluid absenc viral rna system inflamm astrocyt activ tryptophan metabol pathway associ post covid neurolog syndrom whether process independ intertwin hiv covid infect requir studi
|
D015497;D015658;D000086382;D009422
|
T005;T067;T047
|
36,346,956
|
well therapi lifestyl intervent type diabet pilot random control trial pilot random control trial evalu preliminari efficaci month well therapi wbt lifestyl intervent among adult type diabet overweightobes
|
D003924
|
T047
|
36,346,955
|
relationship abus histori gastrointestin extraintestin symptom sever irrit bowel syndrom studi aim investig associ differ abus type gastrointestin gi extraintestin symptom sever irrit bowel syndrom ib possibl mediat relationship
|
D043183;D002650
|
T047;T048
|
36,346,953
|
radiograph respons solitari plasmacytoma conform radiotherapi may delay outcom era although recurr rate radiotherapi solitari plasmacytoma sp well establish littl known sp respond radiograph histor patient treat era evalu respons radiotherapi among sp patient stage treat techniqu includ proton therapi yet previous report
|
D010954;D001859;D020266
|
T061;T191
|
36,346,848
|
utero exposur great depress reflect late life epigenet age signatur research matern fetal epigenet program argu advers exposur intrauterin environ long term effect adult morbid mortal howev causal research epigenet program human popul level rare often unabl separ intrauterin effect condit postnat period may continu impact child develop studi use quasi natur experi leverag state year variat econom shock great depress examin causal effect environment exposur earli life late life acceler epigenet age particip us health retir studi hrs hrs first popul repres studi collect epigenom wide dna methyl data sampl size geograph variat necessari exploit quasi random variat state environ expand possibl causal research epigenet find suggest exposur chang econom condit last impact next generat epigenet age signatur develop predict mortal risk grimag physiolog declin dunedinpoam show effect local utero period specif oppos preconcept postnat childhood earli adolesc period evalu endogen shift mortal fertil relat depress era birth cohort conclud effect like repres lower bound estim true impact econom shock long term epigenet age
|
D044127;D011297
|
T045;T037
|
36,346,847
|
smc protein recn drive reca filament transloc vivo homolog search molecular repertoir homolog recombin pathway well studi search mechan enabl recombin distant homolog region poor understood earlier work suggest recombinas reca essenti compon homolog search form elong filament nucleat break site reca structur carri long distanc search remain unclear follow dynam reca induct singl doubl strand break caulobact chromosom find reca nucleoprotein filament form rapid transloc direct manner cell undergo sever pole pole travers homolog search complet concomit transloc observ dynam variat length filament import vivo reca filament alon incap long distanc movement transloc associ length variat conting action structur mainten chromosom smc like protein recn via atpas cycl summari uncov three key element homolog search driven recn mobil finit segment reca chang filament length abil conduct multipl pole pole travers togeth point optim search strategi
|
D011938;D001426
|
T123;T126;T116
|
36,346,846
|
highest elev frog provid insight mechan evolut defens high uv radiat defens ultraviolet uv radiat exposur essenti surviv especi high elev speci although specif gene involv uv respons report full view uv defens mechan remain larg unexplor herein use integr approach analyz uv respons highest elev frog nanorana parkeri show less damag effici antioxid activ skin frog lower elev relat uv exposur also reveal gene relat uv defens correspond tempor express pattern n parkeri genom metabolom analysi along larg scale transcriptom profil reveal time depend coordin defens mechan n parkeri also identifi sever microrna play import regulatori role especi decreas express level cell cycl gene moreov multipl defens gene ie tyr melanogenesi exhibit posit select function enhanc substitut thus express shift gene mutat contribut uv adapt n parkeri work demonstr genet framework evolut uv defens natur environ
|
D014466;D001001
|
T011;T070
|
36,346,845
|
hedgehog interact protein act habenula regul nicotin intak hedgehog interact protein hhip sequest hedgehog ligand repress smoothen smo mediat recruit gli famili transcript factor allel variat hhip confer risk chronic obstruct pulmonari diseas smoke relat lung diseas under mechan unclear use singl cell cell type specif translat profil show hhip express high enrich medial habenula mhb neuron particular mhb cholinerg neuron regul avers behavior respons nicotin hhip defici dysregul express gene involv cholinerg signal mhb disrupt function nicotin acetylcholin receptor nachr ptch cholesterol depend mechan crisprca mediat genom cleavag hhip gene mhb neuron enhanc motiv properti nicotin mice find suggest hhip influenc vulner smoke relat lung diseas part regul action nicotin habenular avers circuit
|
D019262;D011978;D008171
|
T047;T023;T116;T192
|
36,346,844
|
porphyrin nanoemuls antimicrobi photodynam therapi effect deliveri inactiv biofilm relat infect manag biofilm relat infect challeng healthcar antimicrobi photodynam therapi apdt power tool demonstr broad spectrum activ nanotechnolog use increas apdt effect improv photosensit deliveri properti newp simpl versatil safe surfact free nanoemuls porphyrin salt shell encapsul food grade oil core promis photodynam action studi evalu use newp apdt microorgan plankton biofilm vivo model infect wound first potenti newp mediat apdt inactiv streptococcus pneumonia staphylococcus aureus suspens evalu seri protocol assess aureus biofilm mean cell viabil confoc microscopi final best biofilm protocol use treatment aureus murin infect wound model high newp bacteria cell interact achiev sinc nm jcm abl kill pneumonia suspens aureus biofilm enhanc efficaci newp apdt achiev newp appli longer period incub light dose jcm best singl doubl session protocol reduc log log respect homogen newp distribut result high number dead cell apdt vivo model show one apdt session enabl reduct log faster tissu heal group conclus newp apdt may consid safe effect anti biofilm antimicrobi photosensit
|
D010778;D011166;D000890
|
T061;T123;T121;T109
|
36,346,843
|
ancestr sex role plastic facilit evolut sex sexual behavior recent attempt explain evolutionari preval sex sexual behavior ssb focus role indiscrimin mate howev mani case ssb may complex simpl mistaken ident instead involv mutual interact success pair partner detect sex behavior plastic essenti express ssb circumst test behavior plastic role evolut ssb use termit studi femal male modifi behavior sex versus heterosexu pair male termit follow femal pair tandem mate movement pattern sexual dimorph previous studi observ adapt sex tandem also occur sex found stabl sex tandem achiev behavior plastic one partner adopt sex movement result behavior dimorph simul base empir obtain paramet indic social cu plastic contribut pair mainten dimorph movement improv reunion success upon accident separ systemat literatur survey phylogenet compar analysi suggest ancestor modern termit lack consist sex role pair indic plastic inherit ancestor socioenvironment induct ancestr behavior potenti may widespread import express ssb find challeng recent argument promin role indiscrimin mate behavior evolutionari origin mainten ssb across divers taxa
|
D012726;D020049
|
T204;T054
|
36,346,842
|
leverag natur murin meiotic drive suppress invas popul invas rodent major caus environment damag biodivers loss particular island unlik insect genet biocontrol strategi includ popul suppress gene drive bias inherit develop mice demonstr gene drive strategi crispr leverag super mendelian transmiss haplotyp spread inactiv mutat haplosuffici femal fertil gene prl use spatial explicit individu base silico model show crispr erad island popul rang realist field base paramet valu also engin transgen crispr mice crucial exhibit bias transmiss modifi haplotyp prl mutat level model predict would suffici erad exampl feasibl gene drive system invas alien rodent popul control
|
D044822;D000075423
|
T063;T080
|
36,346,841
|
orthopaed manag gout gout character deposit monosodium urat crystal patient chronic elev blood level uric acid common form inflammatori arthriti unit state often comorbid hypertens obes chronic kidney diseas initi present usual acut warm swollen joint common first metatarsophalang joint varieti locat may affect main treatment gout medic manag acut inflamm chronic uric acid level surgic treatment may indic case damag surround soft tissu concomit septic arthriti symptomat cartilag loss neurolog deficit base literatur date gout seem independ affect outcom total hip knee ankl arthroplasti associ comorbid affect outcom patient consid
|
D009985;D006073
|
T047;T091
|
36,346,839
|
interf sting clathrin associ adaptor protein complex ap stop sting signal golgi
|
D002966;D033942
|
T123;T116
|
36,346,838
|
oral activ small molecul tnf inhibitor disrupt homotrimer interfac improv inflammatori arthriti mice excess signal proinflammatori cytokin tnf involv sever autoimmun diseas includ rheumatoid arthriti ra howev unlik approv biolog current use treat condit commerci avail small molecul inhibitor tnf trimer cytotox exhibit low potenc report tnf inhibitori molecul tim reduc tnf signal vitro effect treatment mous model ra initi lead compound tim attenu tnf induc apoptosi human mous cell delay induct proinflammatori nf b mapk signal caspas caspas depend apoptosi tim inhibit secret proinflammatori cytokin il il disrupt tnf homotrimer therebi prevent associ tnf receptor mous model collagen induc polyarthr potent tim analog timc oral bioavail reduc paw swell histolog indic knee joint patholog inflammatori infiltr joint overal arthriti index oral deliv timc show immunolog effect similar elicit intraperiton inject fda approv tnf receptor decoy etanercept thus timc promis lead compound develop small molecul therapi treatment ra tnf depend system inflamm disord
|
D001169;D001172
|
T047;T050
|
36,346,837
|
metabolit activ tumorigen signal pathway tumor microenviron role metabolit exchang tumor microenviron larg thought fuel drive increas biosynthet bioenerget demand grow tumor howev view shift metabolit increas shown function signal molecul direct regul oncogen pathway combin grow understand essenti role stromal cell shift led increas interest collect interconnect metabolom tumor microenviron drive malign transform epitheli mesenchym transit drug resist immun evas metastasi review discuss metabolit exchang tumor various cell type tumor microenviron fibroblast adipocyt immun cell activ signal pathway drive cancer progress
|
D059016;D009369
|
T070;T191
|
36,346,836
|
evolutionarili conserv coronin depend pathway defin cell popul size mainten cell popul size fundament proper function multicellular organ describ cell intrins cell densiti sens pathway enabl cell reach maintain appropri popul size pathway oper kin kin ident similar cell popul occupi nich within tissu organ lymph node spleen blood show pathway depend cell densiti depend abund evolutionarili conserv protein coronin coordin prosurviv signal inhibit cell death cell popul reach threshold densiti threshold densiti coronin express peak remain stabl therebi result initi apoptosi kin kin intercellular signal return cell popul appropri cell densiti cell popul size control pathway conserv amoeba human thus provid evid exist coronin regul evolutionarili conserv mechan cell inform coordin relat popul size
|
D008840;D015107
|
T123;T121;T116;T109
|
36,346,830
|
thrombot storm coronavirus diseas under mechan manag introduct coronavirus diseas covid identifi decemb wuhan china associ high mortal rate worldwid hypothesisgap statement thrombot problem coagulopathi common covid patient despit anticoagul thrombosi common patient intens care unit patient sever diseas although exact mechan coagulopathi covid patient still unclear studi show overactiv renin angiotensin system ras cytokin storm endotheli damag format neutrophil extracellular trap net also extracellular vesicl ev respons covid induc inflamm lead system coagul thrombosi aim manag covid patient requir use basic readili avail laboratori marker admiss hospit critic understand pathophysiolog covid induc coagulopathi treatment strategi review attempt explain under mechan covid coagulopathi diagnosi associ success treatment strategi conclus exact mechan behind covid relat coagulopathi still unclear sever studi reveal mechan research need determin best anticoagul regimen studi therapeut option
|
D000086382;D013927
|
T047;T046;T067
|
36,346,829
|
effect bushen zhuangjin decoct drug serum sox express chondrocyt phenotyp vitro introduct bushen zhuangjin decoct bzd well known formul tradit chines medicin wide use treatment osteoarthr oa due poor intrins repair capac chondrocyt promot prolifer chondrocyt effici treatment delay progress cartilag degrad hypothesisgap statement therefor explor regulatori mechan bushen zhuangjin decoct chondrocyt contribut repair chondrocyt injuri oa may serv potenti therapi oa diseas aim investig express distribut sox mediat serum contain bushen zhuangjin decoct bzd therapeut effect chondrocyt injuri rat methodolog subcultur second generat rat chondrocyt random divid four group interven medium contain differ serum includ blank serum group low concentr bzd group medium concentr bzd group high concentr bzd group viabil prolifer apoptosi chondrocyt detect mtt assay flow cytometri gene protein level sox aggrecan type ii collagen gene analys qrt pcr western blot analysi immunofluoresc stain use analys express distribut sox inflammatori factor differ cultur medium chondrocyt detect elisa result compar control group activ chondrocyt bzd drug contain serum group signific enhanc degre apoptosi signific decreas gene protein level sox proteoglycan aggrecan collagen ii chondrocyt increas signific inflammatori factor cultur medium also decreas signific experi medium concentr group bzd drug contain serum best effect conclus research result show bzd medic serum regul express sox reduc releas inflammatori factor promot chang phenotyp chondrocyt protect chondrocyt damag
|
D019902;D055758
|
T123;T116;T025
|
36,346,828
|
molecular pattern clinic import fluoroquinolon resist multidrug resist klebsiella pneumonia isol nosocomi outbreak shanghai pr china introduct soar resist klebsiella pneumonia fluoroquinolon pr china substanti limit applic antimicrobi especi clinic set threaten persist carbapenem resist k pneumonia crkp necessit strict implement antimicrobi stewardship activ enhanc surveil infect control hypothesi interplay plasmid mediat quinolon resist pmqr determin quinolon resist determin region qrdr mutat acquisit clinic import fluoroquinolon resist ci fr profil multidrug resist k pneumonia mdr kp isol aim investig high risk crkp clone respons nosocomi spread analys molecular pattern ci fr mdr kp isol tertiari hospit shanghai pr china methodolog total isol includ crkps molecular character investig includ antimicrobi suscept test multilocus sequenc type mlst wzi genotyp pcr sequenc phylogenet analysi resist associ gene clinic inform retriev medic record result two high risk crkp clone st wzi st wzi wzi identifi respons nosocomi outbreak intens care unit icu neurosurgeri depart potenti respiratori rout qrdr mutat gyra parc detect isol st sfdasi st sidgsi st dasi respect pmqr gene qnr aac ib cr oqx ab present isol alon combin co occur gene bla encod lactamas rrna methylas putrescin abc permeas acrr acrab transcript repressor insert inactiv like element st isol encod sequenc ompk ompk gene associ specif sts wzi allel st st wzi st isol frameshift disrupt ompk specif gd insert posit ompk isol clinic import ciprofloxacin resist mic mg l includ isol st st st multipl qrdr mutat plus pmqr determin st wzi anoth unknown resist mechan st wzi ciprofloxacin suscept isol maintain intact ompk gene includ two crkps st wzi kpc ndm coproduc st wzi plus carbapenem suscept isol st wzi st wzi st wzi conclus select pressur accumul mutat three type qrdr acrr ompk acquisit resist confer gene continu contribut ci fr mdr kp isol
|
D003428;D015363;D007710
|
T047;T109
|
36,346,826
|
discuss spiritu health primari care hope tool mix method survey gp view uk general medic council gmc royal colleg general practition rcgp requir doctor consid spiritu health consult document barrier discuss spiritu health suggest tool help overcom
|
D001291;D058005
|
T097;T041
|
36,346,824
|
knowledg genet test result among caregiv individu spinal muscular atrophi spinal muscular atrophi sma progress recess genet diseas earli identif critic achiev maxim treatment benefit surviv motor neuron smn copi number may need descriptor diseas sever sma type therefor assess knowledg smn copi number among sma caregiv via phone survey patient sma caregiv regist cure sma databas smn copi number file elig descript result report backward stepwis multinomi logist regress determin specif factor predict knowledg smn copi number engag sma communiti odd ratio p lt abil walk p current age time survey p lt posit predict knowledg smn copi number complet survey major n know smn copi number n love one n respond said genet test done motor function increas linear increas smn copi number smn copi number emerg critic descriptor sever sma type becom obsolet earli drug treatment communic smn copi number recommend standard part treatment plan
|
D017028;D009134
|
T099;T098;T097;T047
|
36,346,823
|
albumin prealbumin ratio periton dialysi patient clinic implic outcom predict serum prealbumin level slight higher wherea albumin lower periton dialysi pd hemodialysi hd patient unknown whether albumin prealbumin ratio apr associ mortal risk among pd patient studi aim evalu clinic implic apr predict valu long term outcom pd patient
|
D010530;D007676
|
T061;T047
|
36,346,818
|
matern obes pregnanc children cardiac function structur systemat review meta analysi evid human studi preval obes increas worldwid experiment anim studi demonstr matern obes pregnanc direct affect cardiac structur function offspr could contribut increas cardiovascular diseas cvd risk current systemat overview avail evid regard matern obes alter cardiac structur function human offspr lack systemat search electron databas embas medlin narci incept june includ human studi compar cardiac structur function fetal life onward offspr women without obes review protocol regist prospero intern prospect regist systemat review identifi crd risk bias assess use modifi newcastl ottawa scale result express use standard mean differ smd search yield uniqu public thirteen articl includ compar offspr women without obes fetus women obes lower left ventricular strain indic reduc systol function persist infanc smd confid interv ci standard deviat sd sd fetal life smd ci sd sd infanc furthermor infant born women obes thicker interventricular septum smd sd ci sd children born women without obes conclus cardiac structur function differ fetus children women without obes differ present fetal life persist childhood consist increas cvd risk long term follow research warrant studi offspr older age lack
|
D000079262;D002318
|
T033;T047
|
36,346,817
|
care carer cc result feasibl randomis control trial posit written disclosur older adult carer peopl psychosi older adult carer peopl experi psychosi increas risk develop physic mental health problem due compound factor support care recipi health chang associ age effect intervent exist difficult access maintain prolong engag self direct write therapi frequent refer written emot disclosur wed might suitabl altern intervent improv wellb carer
|
D017028;D011618
|
T099;T098;T097;T048
|
36,346,816
|
estim infect burden covid malaysia malaysia report million case death decemb underestim remain issu due underdiagnosi mild asymptomat case aim estim burden covid case malaysia base adjust case fatal rate acfr data report case mortal collat ministri health offici github march decemb estim total age stratifi month incid rate mortal rate acfr estim new infect infer age stratifi acfr total estim infect march decemb case ci proport covid infect age year n n n n n respect approxim total popul malaysia estim infect covid end decemb estim highlight accur infect burden malaysia provid first nation level preval estim malaysia adjust underdiagnosi natur acquir communiti immun increas approxim popul remain suscept popul estim infect burden critic determin need booster dose calibr public health measur
|
D000086382
|
T047;T067
|
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