PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,348,051
|
photoredox c h function lead site select phenylalanin bioconjug site select chemic bioconjug peptid protein improv therapeut explor modifi protein drug natur abund phenylalanin protein near protein contain least one phenylalanin residu sequenc show potenti biopharmaceut util phenylalanin bioconjug howev coval bioconjug nativ phenylalanin one challeng problem protein modif herein approach protein modif describ reli photoredox method site select bioconjug phenylalanin methodolog valid peptid well protein insulin use straightforward mild condit addit base character near uv cd spectroscopi small angl x ray scatter sax pyrazol label approach permit insulin hexam complet dissoci monomer form thus make potenti candid use rapid act insulin treatment diabet
|
D010649;D011506
|
T123;T121;T116
|
36,348,045
|
random pilot studi oncolog massag treat chemotherapi induc peripher neuropathi pilot random control trial investig massag therapi symptomat relief chemotherapi induc peripher neuropathi cipn determin ideal week frequenc number week provid massag evalu feasibl initi efficaci swedish massag protocol treat lower extrem le cipn inclus criteria le neuropathi attribut oxaliplatin paclitaxel docetaxel attribut caus month sinc last chemotherapi self report neuropathi score scale age particip random one four group le headneckshould control massag time x week week le control massag xweek week complet rate pain qualiti assess scale pqas measur baselin week later patient particip women breast cancer gi cancer mean age yo rang averag year sinc last chemotherapi massag deem feasibl mean complet rate max sd xweek sd xweek statist signific differ statist signific treatment group interact pqas score week follow statist signific treatment schedul main effect pqas subscal p week lower cipn symptom xweek group versus xweek group improv consid clinic signific favor le xweek group complet rate met pre defin feasibl criteria seem observ better outcom cipn symptom reduct intens xweek week massag intervent differ adher regardless whether massag direct cipn affect area howev suggest massag program target cipn affect area direct provid x week week result best outcom
|
D010523;D000970
|
T121;T047;T109
|
36,348,044
|
driver variabl co satur along gradient boreal arctic lake lake signific player global climat sinc sequest terrestri deriv dissolv organ carbon doc emit greenhous gase like co atmospher howev differ environment driver co concentr well constrain along latitudin thus climat gradient aim provid better understand net heterotrophi gas balanc catchment scale set boreal sub arctic high arctic lake assess water chemistri concentr dissolv co well co ratio three group lake separ step approxim degre latitud south eastern norway near n sub arctic lake northernmost part norwegian mainland near n high arctic lake svalbard near n across region co satur level vari satur level henc co satur govern co ratio boreal lake general undersatur sub arctic high arctic lake rang satur oversatur regardless locat major lake co supersatur boreal lake co ratio main relat doc concentr contrast sub arctic high arctic local conduct major statist determin southern part domin granit metamorph bedrock sub arctic site scatter across rang granit sedimentari bed rock major high arctic lake situat limeston result contrast lake alkalin region doc depend co ratio boreal region togeth low alkalin suggest lake heterotroph respir major sourc lake co contrast conduct depend indic co satur sub arctic high arctic lake larg part explain dic input catchment respir carbon weather
|
D060106;D002245
|
T123;T083;T070;T197
|
36,348,043
|
reliabl refer gene abiot stress marker gene klebsormidium niten microalga recent emerg key research topic especi biolog model among green alga klebsormidium niten thank particular adapt environment stress repres interest photosynthet eukaryot studi transit stage lead colon terrestri life toler differ stress manifest chang gene express monitor quantifi amount transcript rt qpcr identif optim refer gene experi normal therefor necessari studi use four statist algorithm follow rankaggreg packag determin best refer gene pair suitabl normal rt qpcr data k niten respons three abiot stress high salin peg induc dehydr heat shock base refer gene abl identifi marker gene respons three abiot stress k niten
|
D018506;D057949
|
T045;T002
|
36,348,041
|
predict model spatial scale forest fire drive factor case studi yunnan provinc china forest fire among major natur disast destroy balanc forest ecosystem construct forest fire predict model investig drive mechan fire driver forest fire help reveal mechan forest fire occurr risk thus contribut prevent control forest fire howev previous studi mechan forest fire driver consid effect differ spatial scale action forest fire driver predict effect therefor present studi propos spatial predict model forest fire consid spatial scale effect forest fire driver predict forest fire risk first base histor forest fire data geograph environment data yunnan provinc geograph weight logist regress gwlr use determin forest fire driver estim probabl forest fire occurr locat fire observ absent multi scale geograph weight regress mgwr use explor spatial scale action differ driver forest fire result show meteorolog factor relat humid air temperatur air pressur sunshin hour daili precipit wind speed topograph factor elev slope aspect anthropogen factor popul densiti road network well veget type signific correl forest fire thus identifi import factor influenc occurr forest fire yunnan provinc mgwr model regress result show role differ forest fire driver forest fire occurr spatial scale differ spatial scale driver altitud aspect wind speed temperatur slope distanc road fire point larger spatial influenc relat stabl spatial heterogen less influenc model evalu result spatial scale driver relat humid sunshin air pressur precipit popul densiti veget type smaller spatial heterogen obvious influenc model evalu result studi provid refer select driver evalu spatial scale effect construct predict region forest fire model
|
D000075923;D005390
|
T070;T067
|
36,348,038
|
infrar nanospectroscop imag dna molecul mica surfac signific effort done last two decad develop nanoscal spectroscopi techniqu own great potenti singl molecul structur detect addit resolv open question heterogen biolog system protein dna complex appli ir afm techniqu becom power leverag obtain simultan absorpt spectra nanoscal spatial resolut studi protein howev afm ir investig dna molecul surfac benchmark nucleoprotein complex nanocharacter remain elus herein demonstr methodolog approach acquisit afm ir map modal correspond absorpt spectra base two differ dna deposit protocol spermidin ni pretreat mica surfac nanoscal ir absorb distinct form dna morpholog mica demonstr seri afm ir absorpt map correspond ir spectrum result thus demonstr sensit afm ir nanospectroscopi nucleic acid research open potenti employ investig nucleoprotein complex
|
D004247;D000538
|
T123;T197;T114
|
36,348,026
|
ocular morpholog trait american cocker spaniel may confer primari angl closur glaucoma suscept acut primari angl closur glaucoma potenti blind ophthalm emerg requir prompt treatment lower elev intraocular pressur human dog pacg canin breed epidemiolog similar human older femal patient overrepres condit american cocker spaniel ac among common breed observ pacg develop dog studi initi sought identifi genet risk factor explain high preval pacg acss use case control breed match genom wide associ studi howev gwas fail identifi candid loci associ pacg breed studi assess intrins ocular morpholog trait may relat pacg suscept breed normal acss without glaucoma crowd anterior ocular segment narrow iridocorn angl ciliari cleft consist anatom risk factor identifi human acss show uniqu featur consist posterior bow iri longer iridolenticular contact mirror revers pupillari block pigment dispers syndrom human ac could hold potenti serv anim model natur occur pacg human
|
D015812;D005902
|
T047
|
36,348,016
|
spectroscop character vitro studi biolog activ bradykinin deriv eleven multipl analog bradykinin peptid natur ligand b b receptor bind activ b receptor unless arg remov sequenc action carboxypeptidas n synthes biolog activ examin rex cell line express b b receptor use intracellular ip assay mrna express br br lysat tumor cell line eg u mg human astrocytoma shp human small cell lung cancer h human brain glioma determin five br antagonist adsorpt liquidsolid interfac au nanoparticl aunp serv solid surfac discuss term vibrat molecular fragment structur factor respons biolog properti analog
|
D001920;D053768
|
T125;T123;T116;T073
|
36,348,015
|
vaccin rift effect provid evid sourc vaccin status determin reject call get vaccin covid vaccin protect individu help end pandem sizabl minor western countri reject vaccin vaccin status serv group membership critic communic group undermin trust accord suggest call get vaccin vaccin sourc lead defens reject instead desir behavior chang term vaccin rift effect uniqu collabor nation print onlin tv news media yield larg n age repres sampl austrian citizen fulli random experi particip exhibit vaccin rift ascrib less construct motiv ci experienc threat ci ascrib wors person characterist vaccin vs unvaccin comment ci construct consist predict behavior measur counterargu vaccin plan indirect effect b se b se vaccin rift substanti stronger among critic group unvaccin particip ds among fulli vaccin ds discuss appli psycholog mechan vaccin rift public campaign
|
D000086382
|
T047;T067
|
36,348,009
|
evid unidimension structur mind percept last decad wit intens interest peopl perceiv mind entiti human non human anim non live object forc percept impact behavior despit attent paid topic psycholog structur mind percept under properti account varianc across judgement entiti clear extant report conflict term understand structur present research evalu psycholog structur mind percept particip evalu wide array human non human anim non anim entiti use entir within particip design vari measur approach data driven analys four studi demonstr mind percept best conceptu along singl dimens
|
D056345
|
T078
|
36,348,002
|
improv general combat method harmon radiom featur radiom approach precis medicin promis variat associ imag acquisit factor result sever bias low generaliz multicent dataset use studi often heterogen multipl imag paramet andor miss inform result multimod radiom featur distribut combat promis harmon tool harmon singleknown variabl assum standard input data normal distribut propos procedur sequenti harmon multipl batch effect optim order call opnest combat furthermor propos address bimod employ gaussian mixtur model gmm group consid either batch variabl opnest gmm protect clinic covari opnest gmm method evalu featur extract captk pyradiom two public lung comput tomographi ct dataset found opnest combat improv harmon perform standard combat opnest gmm combat exhibit best harmon perform lowest predict perform opnest gmm combat show poorer harmon perform highest predict perform find emphas improv harmon perform guarante improv predict perform method show promis superior standard dataset heterogen multipl unknown imag paramet greater generaliz
|
D014057
|
T060
|
36,348,001
|
singl nucleus transcriptom idh tp mutant glioma stem cell display diversifi commit invas cancer progenitor glioma devast brain tumor high mortal rate attribut glioma stem cell gscs possess high plastic marker mutat isocitr dehydrogenas type idh tumor protein tp frequent glioma impact cell fate decis understand gsc heterogen within idh tp mutant tumor may elucid possibl treatment target perform singl nucleus transcriptom mutant wild type glioma sampl sort sox stem cell marker first time rare subpopul sox idh tp mutant gscs character general gscs contain heterogen root subpopul resembl activ neural stem cell capabl asymmetr divis quiescent transit amplifi cell branch specif doubl mutant gscs reveal commit high invas oligodendrocyt astroglia like progenitor addit doubl mutant gscs display upregul marker collagen synthesi alter lipogenesi high migrat wild type gscs express gene relat atp product wild type gsc root popul high heterogen lack signatur marker express thus glioblastoma treatment emphas establish differenti protocol direct residu gscs differenti idh tp mutant glioma suggest therapeut target migrat molecul cd
|
D005910;D001932
|
T191
|
36,348,000
|
signific brinkman stoke system conjunctur human knee joint stoke equat fluid domain brinkman equat porous media combin current studi design stoke brinkman coupl current paper give theoret analysi stoke brinkman coupl shown model good match knee joint flow model investig order get better understand convect diffus viscous flow along articular surfac joint beaver joseph slip condit specif boundari condit synovi fluid use solv govern system partial differenti equat synovi fluid result provid develop formula interfaci veloc flow special slip condit analys link slip paramet formula see text formula see text thus damp forc due porous medium natur non dimension paramet control structur like formula see text formula see text develop analyt solut numer simul use finit volum approach hope mechan nutrit transport synovi joint better understood accord data averag concentr negat connect axial distanc durat spent experi mani graph util gain understand problem various characterist includ veloc concentr among other hyaluron ha consid present porous cartilag surfac viscos synovi fluid fluctuat respons amount ha present
|
D007719;D013582
|
T031;T030
|
36,347,998
|
fixat free laparoscop obliter inguin hernia defect dynam respons scaffold proflor laparoscop tapptep approach well establish option cure inguin hernia open approach mesh fixat poor qualiti biolog respons repres controversi question sourc concern furthermor hernia defect patenc repres anoth problem seem well acknowledg among surgeon problem consid caus frequent intra postop complic overcom concern recent differ concept cure emerg base newli develop dynam respons scaffold name proflor perman hernia defect obliter final follow inher centrifug expans due dynam respons hernia devic posit fixat free within defect induc probiot biolog respons allow establish degener inguin barrier laparoscop approach scaffold test patient demonstr effect reduc intra postop complic oper patient present bilater andor recurr inguin hernia overal hernia defect obliter dynam respons scaffold procedur carri januari januari defin protocol detail procedur step laparoscop techniqu hernia scaffold allow fixat free placement perman defect obliter dynam induc regen effect techniqu prove effect reduc intra postop complic particular earli postop pain discomfort signific decreas chronic pain recurr report follow result achiev describ laparoscop techniqu seem embodi innov concept inguin hernia repair fixat free dynam respons perman defect obliter histolog proven regen effect distinct featur scaffold seem embodi physiolog pathogenet coher concept cure thus improv treatment result widespread diseas
|
D006552;D010535
|
T060;T047;T190;T061
|
36,347,995
|
local periodont kidney function risk proteinuria young adult chief oral health studi studi aim investig associ local periodont proteinuria militari young adult taiwan local periodont classifi healthystag n stage iiiii n stage chronic kidney diseas ckd defin estim glomerular filtrat rate egfr mlmin proteinuria defin protein level dipstick test multipl logist regress analysi adjust age sex bodi mass index remain teeth number potenti covari use determin associ local stage iiiii periodont dipstick proteinuria patient without ckd local stage iiiii periodont associ higher risk dipstick proteinuria odd ratio confid interv stage ckd howev associ local stage iiiii periodont dipstick proteinuria observ patient stage ckd associ null particip without stage ckd find suggest among young adult especi mild impair egfr local periodont might contribut acut chronic kidney injuri manifest proteinuria
|
D051436;D010518
|
T047
|
36,347,994
|
klf suppress tumor growth metastasi tripl negat breast cancer downregul ccl ccl kruppel like factor klf transcript factor belong kruppel like factor klf famili gene recent report tumor suppressor gene breast cancer howev specif mechan klf inhibit brca elucid investig role mechan klf tripl negat breast cancer tnbc klf express methyl detect rt qpcr rt pcr methyl specif pcr breast cancer cell line tissu effect klf tnbc cell function examin via various cellular function assay specif anti tumor mechan klf investig rna sequenc rt qpcr western blot luciferas assay chip bioinformat analysi result show klf signific downregul breast cancer cell line tissu promot methyl klf partial contribut exogen express klf induc apoptosi gm phase cell cycl arrest suppress cell prolifer metastasi vivo tumorigenesi tnbc cell mechan studi reveal klf target downregul c c motif chemokin ligand ccl ccl moreov transcriptom metabolom analysi reveal klf involv key anti tumor regulatori metabol pathway tnbc conclus klf suppress cell growth metastasi tnbc downregul ccl ccl klf may prognost biomark tnbc
|
D064726
|
T191
|
36,347,972
|
prospect control studi util rotat thromboelastometri surgeri acut type aortic dissect evalu hemostat system rotem patient undergo surgeri acut type aortic dissect ataad use elect aortic procedur control prospect control observ studi studi perform tertiari referr center univers hospit twenti three patient ataad compar control patient undergo elect surgeri ascend aorta aortic root rotem intem extem heptem fibtem test point time surgeri ataad elect aortic surgeri ataad group activ coagul come surgic theatr two group show activ major coagul pathway surgeri ataad group consist larger defici revers coagulopathi success although none group reach elect baselin postop day rotem detect low level clot factor heparin revers low level platelet studi demonstr ataad associ coagulopath state surgeri caus addit damag hemostat system ataad patient well patient undergo elect surgeri ascend aorta aortic root rotem adequ catch full coagulopathi ataad transfus protocol ataad specif creat target complex coagulopath state rotem negat need routin laboratori test
|
D000784;D001778;D006490
|
T121;T047;T046
|
36,347,970
|
analysi earli iron age bp modern period bp starch grain western central africa starch grain analysi carri ceram sherd refus pit site nachtig central cameroon shed light longstand debat regard ancient diet central africa iron age ia year bp also recent modern period ca bp result indic vari balanc diet consist cereal legum oil rich seed tuber latter rare document region moreov underscor presenc taxa still consum today recent time rescu archaeolog applic special methodolog critic better nuanc past dietari practic region
|
D013213;D001106
|
T090;T123;T121;T091;T109;T168
|
36,347,969
|
pre transplant platelet lymphocyt ratio predict outcom allogen hematopoiet stem cell transplant mani patient hematolog malign acut leukemia myelodysplast syndrom allogen hematopoiet stem cell transplant allogen hsct curat treatment option despit curat potenti treatment mani patient experi relaps under diseas die due multipl complic eg infect risk score could help assess individu prognosi guid patient treat physician choos differ treatment option paramet reflect inflammatori status neutrophil lymphocyt ratio nlr monocyt lymphocyt ratio mlr platelet lymphocyt ratio plr demonstr associ prognosi treatment complic patient various cancer studi evalu pre hsct nlr mlr plr predict marker patient undergo allogen hsct demonstr high plr level associ better clinic outcom patient high pre hsct plr show signific better overal surviv p less relaps p lower non relaps mortal p less transfus red blood cell platelet fresh frozen plasma p fewer episod fever p consider less differ antibiot p fewer intens care unit treatment p lower hospit mortal p pre hsct plr easi calcul daili routin could help predict patient outcom allogen hsct
|
D008214;D018380
|
T061;T025
|
36,347,955
|
link agrin signal ca v neuromuscular junction spinal muscular atrophi smn protein defici caus motoneuron diseas spinal muscular atrophi sma smn base therapi improv patient motor symptom variabl degre earli hallmark sma perturb neuromuscular junction nmj synaps motoneuron muscl cell nmj format depend acetylcholin receptor achr cluster trigger agrin co receptor lipoprotein receptor relat protein lrp transmembran muscl specif kinas musk signal pathway previous shown flunarizin improv nmjs sma model mice mechan remain elus show flunarizin promot achr cluster cell autonom dose agrin depend manner cc myotub associ increas protein level lrp integrin beta alpha dystroglycan three agrin co receptor furthermor flunarizin enhanc musk interact integrin beta phosphotyrosin moreov drug act express splice agrn cacnah gene muscl specif manner reveal cacnah encod protein cav close associ vitro agrin co receptor lrp vivo enrich nearbi nmjs neonat develop drug increas immunolabel sma muscl thus flunarizin modul key player nmj identifi ca v new protein involv nmj biolog
|
D018171;D009134
|
T123;T047;T116
|
36,347,953
|
cellulos nanofibril silver nanoparticl enhanc mechan antimicrobi properti polyvinyl alcohol nanocomposit film recent find microplast marin food fish crab shrimp necessit need develop biodegrad packag materi studi report develop biodegrad pack materi cellulos nanofibril polyvinyl alcohol nanocomposit embed silver nanoparticl microcrystallin cellulos isol sugarcan bagass via kraft process follow convers cellulos cellulos ii use naohureawat solut nanofibril isol use tetramethylpiperidin yl oxyl tempo use reinforc element polyvinyl alcohol composit prepar solvent cast tensil strength water solubl optic properti water vapor permeabl wettabl prepar film evalu antimicrobi potenc film evalu use disc diffus antimicrobi assay select microorgan
|
D053768;D031786;D053761;D000890;D053758
|
T121;T073;T002
|
36,347,952
|
test retest reliabl splenic volum assess ultrasonographi mri ct gold standard assess splenic size clinic set ultrasonographi particular suit due portabl cost effici easi util howev ultrasonographi associ subject assess potenti result increas variat use test retest design aim determin reliabl splenic measur assess ultrasonographi apnea addit compar reliabl differ equat volum calcul koga prolat ellipsoid pilstrm twelv healthi particip women perform two test separ min compris maxim voluntari apnea seat posit splenic dimens measur via ultrasonographi min immedi follow apnea rest splenic volum display high test retest reliabl test pilstrm ml vs ml p icc p cv prolat ellipsoid ml vs ml p icc p cv koga ml vs ml p icc p cv apnea induc volum display similar reliabl ml vs ml p icc p cv reliabl also high equat pilstrm vs prolat ellipsoid icc p cv bias ml loa ml pilstrm vs koga icc p cv bias ml loa ml conclud splenic ultrasonograph measur practic applic laboratori field base research reliabl method detect splenic volum chang consist repeat test pilstrm equat display similar reliabl compar prolat ellipsoid formula slight higher compar koga formula may particular use account individu differ splenic dimens
|
D001049;D010706
|
T184;T121;T131;T109
|
36,347,951
|
match amino acid membran prefer profil improv activ antimicrobi peptid antimicrobi peptid amp cation antibiot kill multidrug resist bacteria via membran insert howev weak activ limit clinic use iron cation charg amp essenti membran bind obstruct membran insert studi postul problem overcom locat cation amino acid energet prefer membran surfac amino acid energet prefer less prefer membran posit profil profil strong relat membran insert howev amp follow profil one except protegrin power neglect amp present studi found potent amp wcopw strong resembl protegrin match sequenc prefer posit profil close correl antimicrobi activ one deriv wcopw antimicrobi activ compar effect amp clinic use
|
D000596;D000089882
|
T123;T121;T116
|
36,347,950
|
negat impact xenophobia compass suffer group member attenu trait empathi empathi enabl human be understand share intern state other studi show empathi pain higher group compar group member might driven attitud bias toward group subject design n particip fill questionnair measur xenophobia trait empathi present photo suffer individu either group group rate respect negat affect willing help depict person result show compass member group general negat effect xenophobia state empathi group condit addit moder analys show effect less evid presenc high trait empathi score result highlight import empathi train attenu effect xenophob attitud social cohabit increas polar cultur divers societi
|
D004645;D065806
|
T055;T054
|
36,347,946
|
interact salin water stress sever reduc growth stress toler physiolog respons guava psidium guajava l salin water stress serious environment issu reduc crop product worldwid current research initi wirehous institut soil environment scienc univers agricultur faisalabad pakistan investig growth stress toler physiolog respons guava salin water shortag guava grown one year pot contain soil eight treatment control ds ds ds control water stress ws ds ws ds ws ds ws complet random design result indic plant growth stress toler physiolog paramet declin higher salin water stress could surviv ds ds ws caus declin dri weight shoot root regard control similar highest decreas stress toler notic ds ws follow ds treatment control find valid guava cultiv soil salin ds could cultiv soil salin ds limit water suppli
|
D054712;D031647
|
T168;T034;T002
|
36,347,941
|
systemat studi hifa cofactor hypox cancer cell hypoxia induc factor alpha hifa transcript factor tf form high structur function protein protein interact tfs promot gene express hypox cancer cell howev despit import tf tf interact still lack comprehens view mani tf cofactor involv cooper studi systemat studi hifa cofactor eight cancer cell line use comput motif mine tool siomic discov potenti hifa cofactor includ known hifa cofactor public databas cofactor statist biolog signific top cofactor studi direct valid literatur remain novel cofactor discov cofactor essenti hifa regulatori function may lead discoveri new therapeut target cancer treatment
|
D005786;D009369
|
T045;T191
|
36,347,940
|
three dimension map reveal heterochron develop neuromuscular system postnat mous skelet muscl develop neuromuscular system includ muscl growth intramuscular neural develop addit central nervous system matur determin motor abil improv motor develop occur asynchron cephal caudal howev whether structur develop differ muscl heterochron unclear base characterist motor behavior postnat mice examin structur featur neuromuscular system differ muscl combin tissu clear optic imag techniqu quantit analys structur data relat mrna express reveal continu myofib hyperplasia forelimb hindlimb muscl around postnat day p p respect well continu axon arbor neuromuscular junction format around p p respect featur alter cervic muscl end birth structur heterochroni muscl differ bodi part correspond motor function structur data neuromuscular system neonat muscl provid perspect understand structur status motor develop
|
D018482;D009469
|
T026;T023;T024
|
36,347,939
|
increas ca v late current cacnac prm variant caus atyp timothi syndrom without syndactyli timothi syndrom ts rare pleiotrop disord associ long qt syndrom syndactyli dysmorph featur neurolog symptom sever variant exon cacnac gene encod subunit voltag gate ca channel ca v known caus classic ts identifi prm exon variant atyp ts case aim studi examin function effect cacnac prm ca v comparison pgr index patient month old femal infant suffer cardio pulmonari arrest associ prolong qt interv show dysmorph facial featur development delay syndactyli interest also present recurr seizur month genet test identifi novel heterozyg cacnac variant prm use heterolog express system hek cell analys whole cell patch clamp techniqu reveal prm caus late ca current signific delay ca v channel inactiv consist under mechan classic ts novel cacnac variant prm found associ atyp ts mechan pgr variant respons classic ts
|
D013576;D008133
|
T033;T019;T047
|
36,347,938
|
intellectu abl adult autism spectrum disord show typic rest state eeg activ broad interest discov quantifi physiolog biomark psychiatr disord aid diagnost assess howev find biomark autism spectrum disord asd proven particular difficult part due high heterogen record five minut eye close rest electroencephalographi eeg adult asd without asd investig potenti eeg biomark classifi asd use three convent machin learn model two layer cross valid comprehens character spectral tempor spatial dimens sourc model eeg result biomark per record found signific group mean group varianc differ eeg featur interest obtain valid accuraci howev best machin learn model mere distinguish asd non autist comparison group mean balanc test accuraci entir unseen test set larg drop model perform valid test stress import rigor model evalu highlight high heterogen asd overal lack signific differ weak classif indic group level intellectu abl adult asd show remark typic rest state eeg
|
D000067877
|
T048
|
36,347,932
|
apic ciliari adhes complex establish basal foot motil cilia depend microtubul network ciliari adhes ca complex form close associ basal bodi cilia earli stage ciliogenesi respons mediat complex interact actin network multicili cell mccs howev precis local respect basal bodi accessori structur interact lead establish mccs well understood studi distribut ca protein use super resolut imag possibl interact microtubul network result studi reveal apic ca complex form distal end basal foot depend microtubul data also rais possibl cas may addit role regul organ microtubul network mccs
|
D002923;D064652
|
T026
|
36,347,930
|
multilevel analysi factor associ perinat intim partner violenc among postpartum popul southern ethiopia violenc around pregnanc critic natur major public health problem worldwid thus present studi aim determin extent perinat partner violenc identifi individu communiti level factor among postpartum women southern ethiopia total postpartum women nest kebl cluster enumer use multistag cluster sampl techniqu multilevel analysi differ paramet comput model comparison model fit overal preval intim partner violenc andor pregnanc estim ci women report continu abus perinat period postpartum women live rural area adjust odd ratio aor ci neighborhood high ipv favor norm aor ci high femal literaci aor ci high femal autonomi aor ci neighborhood lower wealth status aor ci like encount pipv complex pattern interplay factor oper differ level could put pregnant postpartum women higher risk ipv victim therefor polici priorit improv contextu factor particular norm toward ipv women empower like effect intervent
|
D012747;D000066511
|
T033;T053;T098
|
36,347,929
|
stabl reproduc binder free goldcopp core shell nanostructur high sensit non enzymat glucos detect core shell non enzymat glucos sensor general fabric chemic synthesi approach follow binder base immobil process introduc new approach direct synthesi core shell au cu au cu x oxid fto electrod non enzymat glucos detect physic vapor deposit au thin film follow thermal anneal use fabric au nanocor electrod cu shell deposit select au core use electrodeposit method addit au cu au cuo synthes via post thermal anneal au cu electrod binder free select grow approach merit high electrooxid activ owe improv electron transfer abil provid activ site surfac electrochem measur indic superior activ au cu electrod glucos oxid high sensit acm mm low detect limit achiev superior electrod addit sensor indic remark reproduc suppli accur result glucos detect human serum moreov synthesi approach use fast high control precis fabric mani core shell structur adjust electrochem deposit thermal treatment paramet
|
D049329;D015374
|
T059;T073;T075
|
36,347,928
|
cell viabil assess associ contact gas bubbl produc femtosecond laser breakdown cell cultur media high intens near infrar femtosecond laser promis tool three dimension process biolog materi process cell tissu long last gas bubbl random appear around laser focal point howev physicochem mechan effect gas bubbl emphas paper present characterist behavior gas bubbl contact effect cell viabil high speed imag gas bubbl format various addit physiolog medium confirm gas bubbl consist dissolv air amphipath protein stabil bubbl surfac surfac protect layer inhibit interact gas bubbl cell membran consequ gas bubbl contact caus critic effect cell viabil hand burst gas bubbl stimul impact femtosecond laser induc cavit lead liquid jet flow might caus serious mechan damag cell result provid insight paramet biolog tissu process intens fs laser puls
|
D007834;D018929
|
T074;T059;T073
|
36,347,927
|
predict model preoper assess prognost model lymph node metastasi endometri cancer lymph node metastasi lnm well establish prognost factor endometri cancer ec aim construct model predict lnm prognosi use preoper factor myometri invas mi enlarg lymph node lns histolog grade determin endometri biopsi serum cancer antigen ca level use two independ cohort consist ec patient area receiv oper characterist curv auc construct model regardless machin learn techniqu enlarg lns higher serum ca level signific patient low grade ec lgec lnm patient without lnm wherea deep mi higher ca level signific patient high grade ec hgec lnm patient without lnm predict perform lnm hgec group higher lgec group auc respect patient group without postop patholog lnm posit lnm predict signific wors relaps free overal surviv patient negat lnm predict log rank test p studi show preoper clinicopatholog factor predict lnm high precis detect patient poor prognos furthermor clinicopatholog factor associ lnm differ hgec lgec patient
|
D008198;D016889
|
T023;T191
|
36,347,923
|
preval associ factor undiagnos hypertens among adult central african republ studi aim estim preval associ factor undiagnos hypertens htn among adult central african republ car cross section car bangui ombella mpoko step survey person age year non pregnant complet blood pressur measur respond interview biomed physic includ blood pressur measur undiagnos htn classifi systol bp mmhg andor diastol bp mmhg among adult never told doctor health worker rais blood pressur hypertens take antihypertens medic binari logist regress use estim factor associ undiagnos htn among htn n proport undiagnos htn diagnos htn adjust logist regress analysi male sex aor ci current tobacco use aor ci high physic activ aor ci posit associ age aor ci underweight aor ci invers associ undiagnos htn addit among men ever screen glucos aor ci negat associ undiagnos htn among women marri cohabit aor ci current heavi drink aor ci posit associ undiagnos htn seven ten adult popul htn undiagnos htn car effort reinforc screen htn general popul
|
D006973
|
T047
|
36,347,922
|
associ dietari acid load odd sever irrit bowel syndrom adult studi conduct investig associ dietari acid load irrit bowel syndrom ib cross section studi perform investig associ dietari acid load odd ib sever ib subtyp sampl iranian subject select health center isfahan provinc valid semi quantit food frequenc questionnair ds ffq appli estim dietari intak dietari acid load measur use net endogen acid product neap dietari acid load dal potenti renal acid load pral score crude model highest compar lowest categori pral score signific associ increas odd ib sever particip bmi kgm ci also result indic signific posit associ parl odd mix subtyp ib ci p trend propens score adjust model potenti confound posit associ found pral odd mix subtyp ib ci p trend dal neap score tend show non signific similar find studi indic dietari acid load might associ odd mix type ib howev research warrant infer find
|
D043183
|
T047
|
36,347,920
|
quantit evalu correl lumbosacr lordosi pelvic incid stand posit among asymptomat asian adult prospect studi determin lumbopelv align essenti plan adult spinal deform surgeri ensur favor surgic outcom prospect studi investig correl lumbar section lumbar spine lordosi increas pelvic incid asian adult mean age year rang year compris male femal volunt particip divid three group base pelvic incid g g g pelvic incid respect determin distal proxim lumbar lordosi contribut differenti increas pelvic incid wherea lordosi ratio l l l l segment most remain constant mean contribut ratio segment lordosi l follow l l l l l l l l l pelvic incid stronger correl proxim lumbar lordosi distal lumbar lordosi ratio proxim lumbar lordosi distal lumbar lordosi g g g find serv refer futur lumbar spine correct fusion surgeri asian adult
|
D008141;D013123
|
T061;T047
|
36,347,918
|
unlock human inner ear therapeut intervent human inner ear contain minut three dimension neurosensori structur deepli embed within skull base render relat inaccess regen therapi hear loss provid detail characteris function architectur space host cell bodi auditori nerv make safe access first time therapeut intervent use synchrotron phase contrast imag offer requir microscop soft tissu contrast definit simultan display precis boni anatom detail use volum render softwar construct high accur dimension represent inner ear cell bodi arrang boni helic canal spiral base cochlea apex canal volum l diffus potenti l model data tempor bone enabl definit safe trajectori therapeut access preserv cochlea intern architectur valid approach surgic simul anatom dissect micro radiograph analysi find facilit futur clinic trial novel therapeut intervent restor hear
|
D007758
|
T023
|
36,347,917
|
util galerkin finit element strategi investig comparison perform among two hybrid nanofluid model util fourier law heat conduct provid parabol partial differenti equat thermal transport provid inform regard thermal transport initi time mani practic applic theori applic therefor util modifi heat flux model use work discuss util non fourier heat flux model investig thermal perform tri hybrid nanoparticl mixtur immers carreau yasuda materi past riga plate use hamilton crosser yamada ota model consid variabl thermo physic characterist phenomenon present transport momentum energi develop form coupl partial differenti equat complex transform ordinari differenti equat use appropri transform transform equat tackl numer via finit element scheme authent obtain solut shown help compar analysi present result avail open literatur
|
D008962;D006358
|
T062;T170;T070
|
36,347,916
|
competit electrostat interact halogen bond protein ligand system structur thermodynam studi dibromobenzotriazol hck complex ck member cmgc group eukaryot protein kinas cancer drug target effici inhibit halogen benzotriazol benzimidazol depend scaffold substitut pattern ph compound either neutral anion bind pose dictat hydrophob effect desolv tug war salt bridgehydrogen bond k halogen bond e v backbon oxygen test idea bind pose might control ph ligand near neutral pk use condit anion dbbt constitut anion tbbt model character bind low volum differenti scan fluorimetri nanodsf isotherm calorimetri itc hydrogendeuterium exchang hdx x ray crystallographi mx data indic ligand pose away hing domin entir test ph rang insensit bind mode ph attribut perturb ligand pk upon bind keep anion ligand bind pocket test ph valu howev minor popul ligand detect hdx shift toward hing acid condit find demonstr electrostat ionic interact predomin halogen bond
|
D006219;D011506
|
T123;T196;T116
|
36,347,915
|
two independ variant epiderm growth factor receptor associ risk glioma korean popul glioma common primari tumor brain spinal cord previous gwass snps epiderm growth factor receptor egfr report risk loci glioma howev egfr variant associ glioma korean popul remain unstudi studi explor associ egfr snps risk glioma genotyp egfr exon snps case control studi includ korean patient diagnos glioma popul base control statist analys associ egfr snps glioma risk conduct use logist regress stepwis analysi condit logist analysi perform identifi independ associ among genotyp variant confirm two snps rs rs signific associ glioma rs odd ratio p corr rs odd ratio p corr addit stepwis analysi condit logist analysi indic snps creat variant independ genet effect studi first show evid function variant egfr name rs kr rs qq associ increas risk glioma korean popul futur work confirm function associ egfr variant glioma
|
D005910;D001932
|
T191
|
36,347,914
|
rhizospher bacteria associ chenopodium quinoa promot resist alternaria alternata tomato microorgan interact plant promot plant growth act biocontrol agent associ plant growth promot rhizobacteria pgpr enhanc agricultur product improv plant nutrit enhanc protect pathogen microbi applic ideal substitut pesticid fungicid pollut environ reduc biolog divers studi isol bacteri strain root adher soil quinoa chenopodium quinoa seedl bacteri strain exhibit sever pgpr activ vitro includ nutrient solubil product lytic enzym cellulas pectinas amylas siderophor synthesi bacteria found suppress myceli growth fungal pathogen alternaria alternata nine bacteri strain select substanti antagonist activ plant growth promot potenti strain identifi base rrna gene sequenc select planta experi tomato solanum lycopersicum estim growth promot diseas suppress activ among select strain b licheniformi b pumilus effect promot tomato plant growth decreas diseas sever caus alternata infect enhanc activ antioxid defens enzym contribut induc system resist investig provid evid effect viabil pgpr applic particular b licheniformi b pumilus tomato promot plant growth induc system resist make bacteria promis candid biofertil biocontrol agent
|
D018551;D027465
|
T168;T002
|
36,347,913
|
effect gelatin treatment tow deform resin impregn glass fiber potenti use gelatin materi liquid composit mold manufactur lcm process investig specif focus reinforc deform phenomenon adopt gelatin binder composit materi glass fiber applic lcm process evalu analyz permeabl microscop structur gelatin coat glass fiber assess tow deform permeabl non crimp unidirect glass fiber mat evalu differ flow rate could appli lcm process hysteresi permeabl observ flow rate increas decreas indic tow deform permeabl gelatin treat glass fiber mat exhibit relat smaller variat untreat glass fiber flow rate tow deform untreat gelatin treat non crimp glass fiber mat differ flow rate evalu microscop analysi quantifi use tow thick index relat smaller variat permeabl minim chang tow thick gelatin treat glass fiber mat observ via microscop analysi indic gelatin effect maintain bind structur glass fiber mat
|
D005780;D005898
|
T121;T116;T073
|
36,347,912
|
lack associ height cardiovascular prognosi hypertens men women analysi nation real world databas data associ height cardiovascular risk still conflict moreov report show issu hypertens patient studi perform investig whether height affect cardiovascular prognosi hypertens patient use nation wide real world data use korean nation health insur servic databas analyz korean hypertens patient without prior histori cardiovascular diseas januari decemb incid composit cardiovascular death myocardi infarct stroke assess accord height quintil univari comparison taller patient younger age higher proport men multivari cox regress analys height associ occurr cardiovascular event although risk clinic event increas height quintil compar first height quintil tendenc increas risk accord increas height quintil result similar even men women analyz separ quintil group height signific differ clinic outcom sex korean hypertens patient associ height occurr cardiovascular event result differ sex clinic use height cvd predict seem still tricki hypertens patient
|
D006973;D002318;D009203
|
T047
|
36,347,907
|
finit element model effect tissu properti variat human optic nerv tether adduct traction tether optic nerv eye rotat toward midlin adduct signific ocular mechan load suggest caus damag induc repetit eye movement design ocular finit element model fem simul increment adduct beyond initi configur adduct observ threshold tether fem permit sensit analysi tether use observ materi properti variat measur hyperelast anterior equatori posterior peripapillari sclera sheath fem predict adduct beyond initi tether concentr stress strain tempor side optic disc peripapillari sclera sheath junction sclera retrolaminar neural tissu howev unfavor combin tissu properti within publish rang impos higher stress region least favor combin tissu properti adduct tether predict stress junction peripapillari sclera extrem condit intraocular intracrani pressur simul support concept tether adduct could induc mechan stress might contribut damag
|
D009900;D009898
|
T033;T023
|
36,347,905
|
correl brain function connect neurocognit function patient left frontal glioma associ neurocognit function ncf impair brain cortic function connect glioma patient remain unclear correl brain oscillatori activ function connect ncf measur wechsler adult intellig scale full scale intellig quotient score wai fsiq wechsler memori scale revis general memori score wms r gm western aphasia batteri aphasia quotient score wab aq evalu patient left frontal glioma use rest state electroencephalographi eeg current sourc densiti csd lag phase synchron lps analyz use exact low resolut electromagnet tomographi eloreta although patient score borderlin rang wai fsiq wms r gm respect mean wai fsiq wms r gm wab aq valu patient within normal limit none aphasia correl analysi lower wms r gm associ higher lps valu right anterior prefront cortex left superior pariet lobul beta band hz r p find suggest lps evalu scalp eeg associ memori function patient left frontal glioma mild ncf disord
|
D008070;D005910
|
T191;T109
|
36,347,901
|
antibodi depend cellular cytotox null effector develop use mammalian plant glycodelet platform cancer therapi use immun checkpoint inhibitor antibodi mark shift paradigm cancer treatment howev method complet elimin effector function signal regul antibodi urgent requir heterogen glycan chain antibodi limit use therapeut agent due variabl thus develop uniform glycan chain necessari subject anti program cell death protein pd antibodi nivolumab repres immun checkpoint inhibitor glycodelet gd engin remov antibodi depend cellular cytotox adcc antibodi leav one glycan fc glyco engin cho cell prepar overexpress endo n acetyl glucosaminidas endo cho cell n acetyl glucosaminyl transferas knock use cas gd igg nivolumab gd igg nivolumab produc use gd cho cell glycan remov confirm use mass spectrometri target bind pd inhibit alter howev adcc decreas furthermor igg form determin suitabl form gd nivolumab produc plant gd system plant gd nivolumab also reduc adcc without affect pd inhibitori function thus cho plant gd platform use improv signal regul antibodi reduc effector function
|
D007141;D000077594
|
T129;T121;T116
|
36,347,900
|
comparison open robot assist partial nephrectomi approach use multicentr data uroccr studi compar outcom robot assist partial nephrectomi rpn open partial nephrectomi opn use contemporari data respond unmet clinic need data patient includ registri underw partial nephrectomi januari june within centr french network research kidney cancer uroccr collect nct statist method includ adjust multivari analys rate peri post oper transfus surgic revis lower rpn n opn n group vs p vs p lt vs p lt respect multivari analys rpn independ associ fewer earli post oper complic opn overal odd ratio confid interv ci sever p lt shorter hospit stay p lt rpn also signific associ decresedrisk post oper acut renal failur new onset chronic kidney diseas month post surgeri group differ oncolog outcom comparison opn rpn associ improv peri post oper morbid better function outcom shorter hospit stay result support use rpn even larg complex tumour
|
D065287;D007680
|
T061;T191
|
36,347,898
|
galvan vestibular stimul regul nmda receptor vestibular nucleus pd model parkinsonian symptom relief electr stimul construct modul neural network activ galvan vestibular stimul gvs known affect neural activ motor control activ vestibular affer howev under mechan still elus due tight link peripher vestibular organ vestibular nucleus vn effect gvs investig understand neural mechan use spragu dawley sd rat behavior respons extracellular neural record immunohistochemistri vn conduct construct parkinson diseas pd model anim locomot test use rota rod singl extracellular neuron activ record vn immunohistochemistri detect ampa nmda receptor vn assess effect differ amount electr charg coulomb well normal pd gvs pd model show motor impair loss th neuron medial forebrain bundl mfb striatum observ sixti five neuron extracellular activ canal otolith record signific differ rest fire rate kinet respond gain found pd model hand number ampa nmda receptor increas construct pd model effect gvs signific evid chang nmda receptor p conclus increas glutam receptor pd model regul gvs plastic modul main occur nmda receptor vn
|
D016194;D010300
|
T047;T116;T192
|
36,347,897
|
javanes homo erectus move se asia circa migrat homo erectus southeast asia earli pleistocen cardin comprehens evolut genus homo howev limit consider rapid chang physic environ togeth controversi date hominin bear site make challeng secur robust timelin need unveil behavior earli human reapprais first appear datum javanes h erectus ad reliabl age constraint base cosmogen nuclid formula see text formula see text al produc situ compil earlier estim find h erectus reach java dwell sangiran java ca use age baselin develop probabilist approach reconstruct dispers rout coupl ecolog movement simul landscap evolut model forc reconstruct geodynam climat histori demonstr hospit terra firma condit sundaland facilit prior dispers hominin edg java convers could settl javanes archipelago emerg sea connect sundaland dispers h erectus across sundaland occur least ten hundr kyr time scale chang physic environ whether climat physiograph may becom primari forc behavior comprehens reconstruct method unravel peopl timelin se asia provid novel framework evalu evolut earli human
|
D005075;D015186
|
T045;T015
|
36,347,895
|
machin learn base attribut map climat relat discuss social media unit front stakehold includ public administr academia alik requir counter grow threat climat chang recent rise social media new public address system make ideal sourc inform assess public discuss respons real time mine c post climat relat subreddit social media platform reddit sinc incept use use state art sentenc encod k mean cluster algorithm develop machin learn base approach identifi store process classifi post automat scale broad multifacet theme climat chang approach narrow focus critic under theme compris public discuss social media time furthermor employ full order partial correl analysi assess relationship differ identifi theme show line pari agreement climat scienc communiti success influenc discuss caus effect climat chang public administr fail appropri communic caus climat chang abl influenc discuss effect henc studi show clear gap public communic administr wherein counter intuit less emphasi given driver climat chang inform particular benefici policymak climat activist decis make tri close gap public academia
|
D061108
|
T170
|
36,347,894
|
curat collect human vaccin respons signatur recent advanc high throughput experi system biolog approach result hundr public identifi immun signatur unfortun often describ within text figur tabl format amen comput process thus sever hamper abil fulli exploit inform present data model repres immun signatur along human immunolog project consortium hipc dashboard wwwhipc dashboardorg web enabl applic facilit signatur access queri data model captur biolog respons compon eg gene protein cell type metabolit metadata describ context signatur identifi use standard term establish resourc eg hgnc protein ontolog cell ontolog manual curat collect immun signatur publish studi profil human vaccin respons current releas system aid build broader understand human immun respons stimuli enabl research easili access interrog publish immun signatur
|
D049490;D012984
|
T090;T170;T091;T073
|
36,347,893
|
effici comput steadi state time domain solut photon diffus equat layer turbid media accur effici forward model photon migrat heterogen geometri import mani applic light medicin mani biolog tissu exhibit layer structur independ optic properti thick howev close form analyt solut readili avail layer tissu model often model use comput expens numer techniqu theoret approxim limit accuraci real time analysi develop open sourc accur effici stabl numer routin solv diffus equat steadi state time domain layer cylind tissu model arbitrari number layer specifi thick optic coeffici show steadi state formula see text ms time domain formula see text ms fluenc layer medium calcul absolut numer error approach machin precis numer implement increas comput speed order magnitud compar previous report theoret solut layer media verifi solut asymptot homogen tissu geometri use close form analyt solut assess converg numer accuraci approxim solut comput reflect intens present decreas comput time addit order magnitud also compar solut layer media gold standard mont carlo simul layer tissu model high interest biomed optic eg skinfatmuscl brain present routin could enabl robust real time data analysi tool heterogen tissu import mani clinic applic function brain imag diffus optic spectroscopi
|
D017785;D055095
|
T090;T167
|
36,347,892
|
remimazolam besyl sedat postop patient undergo invas mechan ventil icu prospect doserespons studi singl center studi aim determin effect dose safeti remimazolam besyl sedat postop patient undergo invas mechan ventil intens care unit icu mechan ventil patient admit icu surgeri includ narcotrend index nti use assess depth sedat richmond agit sedat scale rass score also record remimazolam besyl administ initi load dose mgkg follow gradual increas mgkg time target depth sedat achiev nti mainten dose remimazolam besyl administ start mgkgh follow increment subtract mgkgh time satisfactori depth sedat achiev maintain least min demograph data anesthesia surgeri type hemodynam respiratori paramet record advers event advers drug reaction monitor safeti twenti three patient eventu includ studi cover period year satisfactori depth sedat achiev singl intraven infus remimazolam besyl load dose mgkg follow mainten dose mgkgh signific chang hemodynam respiratori paramet within min administr remimazolam besyl addit signific correl observ nti rass score assess sedat r p nti show predict probabl rass score remimazolam besyl effect mildmoder sedat invas mechan ventil postop patient icu maintain excel respiratori hemodynam stabil nti use good tool object evalu depth sedat agit
|
D012121;D000758
|
T061
|
36,347,891
|
mendelian random studi reveal causal relationship adiponectin ldl cholesterol african adiponectin associ cardiometabol trait observ studi across popul yet unclear associ causal perform mendelian random mr analysi assess relationship adiponectin cardiometabol trait sub saharan african construct polygen risk score prs adiponectin level across unrel sub saharan african prs use instrument variabl two stage least squar mr analysi assess associ insulin resist hdl ldl total cholesterol triglycerid blood pressur type diabet td hypertens adiponectin prs causal relat ldl ci p valu trait associ observ overweightobes normal weight individu reach statist signific among overweightobes individu ci p valu normal weight individu adiponectin prs associ td ci p valu men hdl ci p valu find first mr studi sub saharan african support causal relationship adiponectin ldl td normal weight individu hdl men observ add small grow literatur adiponectin mr studi
|
D003924;D002318
|
T047
|
36,347,890
|
structur basi sequenc independ substrat select eukaryot wobbl base trna deaminas adat essenti deamin adenosin inosin wobbl base individu trna modif greatest effect mrna decod empow singl trna translat three differ codon date mani aspect eukaryot deaminas specif select multipl substrat remain unclear use cryo em present structur eukaryot adat deaminas bound full length trna reveal enzym distort anticodon loop contrast bacteri enzym select substrat via sequenc independ contact eukaryot acquir flexibl intrins unfold motif distal conserv catalyt core gate mechan substrat entri activ site identifi multi step trna recognit model yield insight rna edit deamin evolv shape genet code direct impact eukaryot proteom
|
D000243;D056890
|
T126;T116;T204
|
36,347,888
|
contrast languag vision learn general fashion concept steadi rise onlin shop goe hand hand develop increas complex ml nlp model use case cast special supervis learn problem argu practition would great benefit general transfer represent product work build recent develop contrast learn train fashionclip clip like model adapt fashion industri demonstr effect represent learn fashionclip extens test across varieti task dataset general probe argu adapt larg pre train model clip offer new perspect term scalabl sustain certain type player industri final detail cost environment impact train releas model weight code open sourc contribut communiti
|
D007802;D009323
|
T171;T066
|
36,347,886
|
improv combust emiss stabil featur diesel methanol blend use n decanol cosolv research endeavor boost applic methanol ci engin util n decanol cosolv work split binari phase first stabil pure methanol hydrous methanol mh diesel refer fuel examin appli various temperatur c c c find show diesel mh diesel combin unstabl thus n decanol util cosolv follow engin combust emiss characterist evalu manipul three proport diesel mixtur n decanol three mixtur compris n decanol denot correspond combin assess via thermogravimetr assess physicochem properti assess correspond astm maximum cylind pressur heat releas rate pressur rise rate diminish respect mdieseln decanol combin compar diesel oil brake thermal effici lower wherea brake specif fuel consumpt enlarg combin compar diesel x smoke opac level diminish respect wherea co uhc enlarg blend compar diesel oil
|
D001335;D000432
|
T131;T130;T109
|
36,347,883
|
applic shear stress enhanc osteogen differenti mous induc pluripot stem cell self organ potenti induc pluripot stem cell ipsc repres promis tool bone tissu engin shear stress promot osteogen differenti mesenchym stem cell lead us hypothes specif shear stress could enhanc osteogen differenti ipsc osteogenesi embryoid bodi form two day maintain medium supplement retino acid three day follow adher cultur osteogen induct medium one day cell subject shear load pa two day among differ magnitud test pa induc highest level osteogen gene express greatest miner deposit correspond upregul connexin cx phosphoryl erk express erk inhibit shear load result decreas osteogen gene express suppress miner deposit result suggest shear stress pa enhanc osteogen differenti ipsc part cx erk signal find shed light applic shear stress technolog improv ipsc base tissu engin bone regen bone therapi
|
D057026;D059630
|
T025
|
36,347,882
|
bifoc flat len differ imag characterist dual sensor imag system wide field view fov imag magnifi imag taken simultan dual sensor imag system propos approach creat bifoc flat len differ imag characterist two foci make dual sensor imag system integr miniatur two special part two differ convent zp extract combin two element specif way two foci differ characterist along optic axi one long focus higher resolut short focus long depth focus dof propos approach thin light bifoc diffract len bdl thick develop long short focal length bdl mm mm respect diamet mm experiment demonstr long focus bdl capabl take high resolut magnifi imag resolut short focus abl take wide fov long dof imag two object spread mm apart imag clear experi result demonstr metric better convent refract len
|
D055095;D005139
|
T090;T074
|
36,347,881
|
prognost predict novel risk score aml drg aml hct cr acut myeloid leukemia patient allogen hematopoiet stem cell transplant aim valid prove novel risk score model acut myeloid leukemia aml specif diseas risk group aml drg aml hematopoiet cell transplant composit risk aml hct cr patient acut myeloid leukemia aml allogen hematopoiet stem cell transplant ahct among aml patient analys n femal median age year rang year two patient year old median follow month rang month accord aml drg model patient low intermedi high risk group respect accord aml hct cr model patient low intermedi high high risk group respect result show aml drg aml hct cr model signific predict cumul incid relaps p p aml drg model associ nrm p univari analysi show aml drg model could better stratifi aml patient differ risk group compar aml hct cr model multivari analysi confirm prognost impact aml drg aml hct cr model post transplant os independ age sex condit type transplant modal stem cell sourc p p aml drg aml hct cr model use effect predict post transplant surviv patient aml receiv ahct compar aml hct cr score aml drg score allow better stratif improv surviv predict aml patient post transplant
|
D018380;D015470
|
T061;T191
|
36,347,880
|
power qualiti approxim household equip load combin use stepwis growth input paramet ai model detach grid subject generat renew energi need balanc compens unstabl power suppli depend local sourc potenti power qualiti pq set eu standard state accept deviat paramet electr power system guarante oper without dropout optim estim pq paramet day horizon essenti oper plan autonom smart grid accommod norm specif equip user demand avoid malfunct pq data system state avail dozen connect switch household applianc defin binari load seri number combin grow exponenti load characterist eventu conting suppli result system instabl unaccept pq event model evolv artifici intellig ai method use self optim algorithm estim unknown case state autonom system conting self suppli power relat chaotic intermit local weather sourc new multilevel extens procedur design increment improv applic adapt train data initi ai model start binari load seri insuffici repres complex data pattern input vector progress extend correl pq paramet next estim level better repres activ demand power consum histor data set compris train sampl pq paramet load sequenc switch applianc avail next estim state valuabl pq paramet select estim previous algorithm stage use supplementari seri next precis comput complex model use previous pq data approxim form secondari process level estim target pq output better qualiti new ad input paramet allow us evolv conveni model form propos multilevel refin algorithm general appli model unknown sequenc state dynam system initi describ binari seri insuffici limit data variabl inadequ problem represent ai comput techniqu adapt strategi improv adapt learn model perform
|
D001185;D006794
|
T090;T073;T066
|
36,347,879
|
new definit human lymphoid follicular cell entiti lymphat tissu machin learn histolog section lymphat system usual basi static morpholog investig perform dynam analysi human reactiv lymphoid tissu use confoc fluoresc laser microscopi combin machin learn base track cell cd b cell cd follicular helper cell pd optic flow follicular dendrit cell cd put forward first quantit analysi movement relat morpholog paramet within human lymphoid tissu identifi correl follicular dendrit cell movement behavior lymphocyt microenviron addit investig valu movement andor morpholog paramet precis definit cell type cd cluster cd cluster could determin base movement andor morpholog differenti cd cd posit cell challeng long term movement characterist indispens propos morpholog movement relat prototyp cell entiti appli machin learn model final defin beyond cd cluster new subgroup within lymphocyt entiti base long term movement characterist conclus show combin imag machin learn abl defin characterist lymphocyt visibl histolog
|
D008221;D020566
|
T025;T024
|
36,347,878
|
spike gene target failur sgtf genom signatur high accur identif alpha omicron sar cov variant alpha b omicron b ba ba ba variant concern voc share sever mutat spike gene includ mutat result delet two amino acid posit del spike protein del caus failur detect gene target wide use commerci test taqpath sar cov rt pcr thermo fisher gene target failur sgtf signatur use preliminarili infer presenc alpha omicron voc evalu accuraci sgtf signatur identifi two variant analysi posit sar cov sampl test taqpath rt pcr sequenc next generat sequenc decemb juli sampl success sequenc includ sgtf posit sampl sensit specif sgtf signatur ci ci alpha variant ci ci omicron variant peak correspond wave posit predict valu sgtf alpha omicron accuraci sgtf signatur high make genom signatur rapid accur proxi identif variant real world laboratori set
|
D000086402;D000086382
|
T005;T067;T047
|
36,347,877
|
costimul blockad combin il permit regulatori cell spare immunomodul inhibit autoimmun blockad cd costimul ctla igabatacept use dampen effector cell respons autoimmun transplant set howev signific drawback approach impair regulatori cell homeostasi requir cd signal therefor strategi restrict effect costimul blockad effector cell would advantag probe relat role cd il maintain treg find provis il counteract regulatori cell loss induc costimul blockad minim affect convent cell compart data suggest combin costimul blockad il treatment may select impair effector cell respons maintain regulatori cell use mous model autoimmun diabet show combin therapi support regulatori cell homeostasi protect diseas find recapitul humanis mice use clinic relev reagent provid exemplar ration use second immunotherapi offset known limit first
|
D050378;D018106
|
T129;T116;T025;T192
|
36,347,876
|
cdkna target phagocytosi mediat cellular immunotherapi acut leukemia target reprogram phagocyt capac tumor associ macrophag tam emerg therapeut opportun cancer treatment demonstr tumor cell phagocytosi drive pro inflammatori activ tam identifi key role cyclin depend kinas inhibitor cdkna p transcript repress signal regular protein sirp p promot leukemia cell phagocytosi subsequ pro inflammatori reprogram phagocyt macrophag extend surround macrophag interferon mous model human cell acut lymphoblast leukemia infus human monocyt mos engin overexpress p ptd mos lead mo differenti phagocytosi profici tam leukemia cell engulf undergo pro inflammatori activ trigger reprogram bystand tam reduc leukem burden substanti prolong surviv mice result reveal p trigger phagocytosi guid pro inflammatori tam reprogram highlight potenti ptd mo base cellular therapi cancer immunotherapi
|
D010587;D015470
|
T191;T043
|
36,347,875
|
estrogen induc immun chang within normal mammari gland breast cancer bca incid increas follow aberr hormon exposur link direct effect estrogen receptor er mammari epithelium estrogen exposur mammari involut shown drive tumour growth via neutrophil potenti er immun microenviron mediat part addit mammari epitheli cell hormon control bca risk normal develop assess collect mammari tissu lymph node blood tumour nave mice treat oophorectomi estrogen estradiol fulvestr flow cytometri use examin impact frequenc innat adapt immun cell oophorectomi fulvestr decreas proport macrophag particular pro tumour polar macrophag neutrophil convers dendrit cell increas therapi eosinophil estrogen increas proport macrophag lesser extent cd cd doubl negat foxp regulatori cell decreas cd cell b cell exclud eosinophil chang restrict mammari tissu suggest inhibit estrogen action lower immun suppress myeloid cell increas antigen present eosinophil mediat direct indirect cytotox effect contrast estrogen exposur drive bca risk increas suppress myeloid cell reduc anti tumour cytotox cell impact hormon exposur bca risk may part link immun modulatori activ
|
D004967;D011960
|
T121;T116;T109;T192;T033;T125
|
36,347,873
|
discoveri small molecul select destabil cryptochrom enhanc life span p knockout mice cryptochrom negat transcript regul circadian clock mammal clear reduc level endogen cri mammal affect circadian rhythm relat decreas apoptosi discov molecul destabil cryptochrom cri vitro vivo select enhanc degrad rate cri increas ubiquitin result increas circadian period length uo bmal dluc cell addit subcellular fraction studi mice liver indic increas degrad cri nucleus furthermor mediat cri reduct enhanc oxaliplatin induc apoptosi ras transform p null fibroblast cell system repetit administr increas median lifespan p mice collect data suggest promis molecul treat form cancer depend p mutat
|
D056931;D057906
|
T123;T040;T116
|
36,347,872
|
effect dissolv humic acid coat humic acid tetracyclin adsorpt k co activ magnet biochar humic acid wide exist water environ import impact adsorpt pollut herein dissolv coat employ assess effect remov organ contamin tetracyclin tc k co modifi magnet biochar kmbc result show low concentr dissolv promot tc remov like due bridg effect higher concentr dissolv inhibit tc adsorpt competit adsorpt site kmbc character analysi coat chang surfac pore characterist kmbc suppress tc remov sequenti adsorpt experi involv dissolv tc addit end experi led format tc ligand free tc improv adsorpt capac tc tc adsorpt kmbc presenc dissolv coat show downward trend increas ph tc adsorpt process favor endotherm could better simul pseudo second order kinet freundlich isotherm model hydrogen bond interact hypothes under influenc mechan
|
D006812;D014874
|
T123;T131;T109
|
36,347,869
|
first mitot divis human embryo high error prone human be made trillion cell aris serial mitot divis singl cell fertilis egg remark earli human embryo often chromosom abnorm mani mosaic karyotyp differ one cell anoth mosaic presum aris chromosom segreg error earli mitot divis although event never visualis live human embryo establish live cell imag chromosom segreg use normal fertilis embryo egg share research programm well embryo deselect fertil treatment reveal first mitot divis extend prometaphasemetaphas exhibit phenotyp caus nondisjunct includ multipolar chromosom segreg lag chromosom lead format micronuclei analysi nuclear number size provid evid equival phenotyp cell human embryo gave rise live birth togeth show error first mitot divis toler human embryo uncov cell biolog event contribut preimplant mosaic
|
D004622;D020090
|
T045;T018
|
36,347,868
|
toward knowledg graph pre probiot microbiota gut brain axi diseas scientif public present biolog relationship structur human read make difficult use resourc semant integr queri exist databas hand well structur autom analysi contain comprehens biolog knowledg devis approach construct comprehens knowledg graph two type resourc appli investig relationship pre probiot microbiota gut brain axi diseas end creat knowledg base dub ppstatement contain manual curat detail annot ii knowledg base call ppconcept contain automat annot concept result pre probiot knowledg graph ppkg combin two knowledg base three public databas ie mesh uml snome ct valid perform ppkg demonstr ad valu integr two knowledg base creat four biolog queri case queri case demonstr retriev co occur concept interest also combin two knowledg base lead comprehens queri result util separ ppkg enabl user pose research queri pre probiot combin may benefit depress potenti lead novel biolog insight
|
D019936;D064307
|
T001;T032;T007;T028
|
36,347,867
|
cell divis drive dna methyl loss late replic domain primari human cell dna methyl undergo dramat age relat chang first describ four decad ago loss dna methyl within partial methyl domain pmds late replic region genom attach nuclear lamina advanc age normal tissu exacerb cancer present experiment evid dna hypomethyl direct driven prolifer associ dna replic within pmds loss dna methyl low densiti cpgs rich immedi context pmd solo wcgws track cumul popul doubl primari cell cultur cell cycl deceler result proport decreas rate dna hypomethyl block dna replic via mitomycin c treatment halt methyl loss loss methyl continu unab tert immort final reach sever hypomethyl equilibrium ambient oxygen cultur condit increas rate methyl loss compar low oxygen condit suggest methyl loss may occur unschedul oxid damag repair associ dna synthesi final present valid model estim relat cumul replic histori human cell call replitali replic time accumul lifetim
|
D019175;D016678
|
T028;T044
|
36,347,866
|
regul brca stabil tandem ubx domain isoleucyl trna synthetas aminoacyl trna synthetas arss evolv acquir various addit domain domain allow arss communic cellular protein order promot non translat function vertebr cytoplasm isoleucyl trna synthetas iarss uncharacter uniqu domain une present crystal structur chicken iar une complex glutamyl trna synthetas ear une consist tandem ubiquitin regulatori x ubx domain interact distinct hairpin loop ear protect neighbor protein multi synthetas complex degrad phosphomimet mutat two serin residu hairpin loop releas iar complex iar interact brca nucleus regul stabil inhibit ubiquityl via ubx domain control dna repair function
|
D007533;D000604
|
T126;T116
|
36,347,865
|
invers design core shell particl discret materi class use neural network design scatter demand challeng task requir investig develop novel flexibl approach paper propos machin learn assist optim framework design multi layer core shell particl provid scatter respons demand artifici neural network learn predict scatter spectrum core shell particl high accuraci act fulli differenti surrog model gradient base design approach enabl fabric particl consid exist materi introduc novel two step optim treat continu geometr paramet discret feasibl materi simultan moreov overcom non uniqu problem expand design space particl vari number shell ie differ number optim paramet classif network method order magnitud faster convent approach forward predict invers design potenti scalabl even larger complex scatter
|
D000465;D016571
|
T170
|
36,347,864
|
magnet nh mil al chitosan nanocomposit novel adsorb remov azithromycin model process optim present studi magnet nh mil al chitosan nanocomposit milc fe ncs synthes use remov azithromycin azt aqueous solut first time synthes milc fe ncs character sem tem xrd ftir bet vsm techniqu effect various key factor azt adsorpt process model optim use respons surfac methodolog base central composit design rsm ccd low valu p valu e rsd paramet along coeffici determin impli develop model well fit experiment data optim condit includ ph adsorb dose gl time min azt concentr mgl remov effici azt adsorpt capac obtain mgg respect fit data langmuir isotherm r x pseudo second order kinet r x show adsorpt process monolay chemic natur h g indic azt remov spontan endotherm natur effect magnesium azt adsorpt complic background ion reus adsorb consecut experi show remov effici reduc perform milc fe ncs real condit also test promis result achiev except treatment azt raw wastewat
|
D048271;D018508;D014874;D053761
|
T121;T073;T109;T131;T052;T057
|
36,347,863
|
generaliz spell use speech neuroprosthesi individu sever limb vocal paralysi neuroprosthes potenti restor communic peopl speak type due paralysi howev unclear silent attempt speak use control communic neuroprosthesi translat direct cortic signal clinic trial particip clinicaltrialsgov nct sever limb vocal tract paralysi singl letter spell full sentenc real time use deep learn languag model techniqu decod letter sequenc particip attempt silent spell use code word repres english letter eg alpha leverag broad electrod coverag beyond speech motor cortex includ supplement control signal hand cortex complementari inform low high frequenc signal compon improv decod accuraci decod sentenc use word word vocabulari median charact error rate speed charact per minut offlin simul show approach general larg vocabulari contain word median charact error rate result illustr clinic viabil silent control speech neuroprosthesi generat sentenc larg vocabulari spell base approach complement previous demonstr direct full word decod
|
D013060;D013067
|
T041;T040;T054
|
36,347,862
|
gzmk high cd effector memori cell associ cd high neutrophil abund non metastat colorect tumor predict poor clinic outcom cd cell major prognost determin solid tumor includ colorect cancer crc howev understand interplay differ immun cell impact clinic outcom still infanc describ interact tumor infiltr neutrophil express high level cd cd effector memori cell em correl tumor progress mechanist stromal cell deriv factor cxclsdf promot retent neutrophil within tumor increas crosstalk cd cell consequ contact mediat interact neutrophil cd cell skew produc high level gzmk turn decreas e cadherin intestin epithelium favor tumor progress overal result highlight emerg gzmk high cd em non metastat crc tumor hallmark driven interact neutrophil could implement current patient stratif target novel therapeut
|
D018414;D015179
|
T191;T025
|
36,347,861
|
pharmacolog blockad tead yap reveal therapeut limit cancer cell target tead autopalmitoyl propos therapeut approach yap depend cancer show tead palmitoyl inhibitor mgh cp analogu block cancer cell stem organ overgrowth tumor initi vitro vivo mgh cp sensit correl signific yap depend larg panel cancer cell line howev tead inhibit yaptaz knockdown lead transient inhibit cell cycl progress without induc cell death undermin potenti therapeut util reveal tead inhibit yaptaz silenc lead vgll mediat transcript activ soxpikakt signal axi contribut cancer cell surviv confer therapeut resist tead inhibitor consist combin tead akt inhibitor exhibit strong synergi induc cancer cell death work character therapeut opportun limit tead palmitoyl inhibitor cancer uncov intrins molecular mechan confer potenti therapeut resist
|
D019869;D009369
|
T191;T126;T116
|
36,347,860
|
singl cell sequenc reveal cd inhibit mediat chang tumor microenviron singl cell sequenc technolog noteworthili improv understand genet map molecular characterist bladder cancer bc identifi cd potenti therapeut target bc via singl cell transcriptom analysi subcutan tumor model orthotop bladder cancer model inhibit cd cdi sodium polyoxotungst abl limit growth bc improv overal surviv tumor bear mice via singl cell rna sequenc find cdi increas intratumor nk cell convent type dendrit cell cdc cd cell decreas treg abund antitumor effect reprogram tumor microenviron blockad nk cell deplet model cdc defici batf model addit signific synergist effect observ cdi cisplatin cdi anti pd l anti pd strategi show synergist effect bc model result confirm cd potenti target immun therapi bc
|
D059016;D001749
|
T070;T191
|
36,347,859
|
evalu commerci avail fulli autom elisa base assay detect anti sar cov neutral antibodi rapid accur measur sever acut respiratori syndrom coronavirus sar cov specif neutral antibodi nab paramount monitor immun infect vaccin subject current gold standard reli pseudovirus neutral test requir sophist skill facil altern recent competit immunoassay measur anti sar cov nab propos quick commerci avail surrog virus neutral test svnt report perform evalu three svnts includ two elisa base assay autom bead base immunoassay detect nab sar cov perform three svnts includ genscript cpass dynamik mindray ntab assess sampl collect sar cov infect patient n covid vaccin individu n pre pandem control n sampl collect infect patient vaccin individu week symptom onset second dose administr correl analysi pseudovirus neutral test pvnt immunoassay detect anti sar cov bind antibodi perform receiv oper characterist roc curv analysi generat assess optim threshold detect nab assay three svnts show excel perform term specif sensit genscript dynamik mindray respect sampl collect vaccin subject genscript demonstr strongest correl pvnt r r follow mindray r r dynamik r r correl anti sar cov bind antibodi variabl strongest correl observ anti rbd igg antibodi mindray r r roc curv analys demonstr excel perform three svnt assay group auc rang p also shown manufactur recommend cutoff valu could modifi base test cohort without signific affect svnt perform svnt provid rapid low cost scalabl altern convent neutral assay measur expand nab test across various research clinic set also could aid evalu actual protect immun popul level assess vaccin effect lay foundat booster requir
|
D000086402;D000086382
|
T005;T067;T047
|
36,347,858
|
systemat tissu annot genom sampl model unstructur metadata current million human omic sampl public avail valuabl resourc remain acut underus discov particular sampl ever grow data collect remain signific challeng major impedi sampl attribut routin describ use vari terminolog written unstructur natur languag propos natur languag process base machin learn approach nlp ml infer tissu cell type annot genom sampl base free text metadata nlp ml work creat numer represent sampl descript use represent featur supervis learn classifi predict tissuecel type term approach signific outperform advanc graph base reason annot method metasra baselin exact string match method tagger model similar relat tissu demonstr nlp ml model captur biolog meaning signal text addit model correct classifi tissu associ biolog process diseas base text descript alon nlp ml model near accur model base gene express profil predict sampl tissu annot distinct capabl classifi sampl irrespect genom experi type base text metadata python nlp ml predict code train tissu model avail https githubcomkrishnanlabtxtonto
|
D000071253;D009323
|
T170;T066
|
36,347,854
|
deep learn base imag analysi predict pd l status h e stain histopatholog imag breast cancer program death ligand pd l recent adopt breast cancer predict biomark immunotherapi cost time variabl pd l quantif immunohistochemistri ihc challeng contrast hematoxylin eosin h e robust stain use routin cancer diagnosi show pd l express predict h e stain imag employ state art deep learn techniqu help two expert pathologist design annot softwar construct dataset assess feasibl pd l predict h e breast cancer cohort patient system predict pd l status high area curv auc system valid two extern dataset includ independ clinic trial cohort show consist predict perform furthermor propos system predict case prone pathologist miss interpret show serv decis support qualiti assur system clinic practic
|
D001943;D000077321;D008175
|
T191;T066
|
36,347,853
|
deep autoencod interpret tissu adapt deconvolut cell type specif gene analysi singl cell rna sequenc becom power tool studi biolog signific characterist explicit high resolut howev applic emerg data current limit intrins techniqu introduc tissu adapt autoencod tape deep learn method connect bulk rna seq singl cell rna seq achiev precis deconvolut short time construct interpret decod train uniqu scheme tape predict cell type fraction cell type specif gene express tissu adapt compar popular method sever dataset tape better overal perform compar accuraci cell type level addit robust among differ cell type faster sensit provid biolog meaning predict moreov analysi clinic data tape show abil predict cell type specif gene express profil biolog signific believ tape enabl acceler precis analysi high throughput clinic data wide rang
|
D059010;D020869
|
T063;T059
|
36,347,849
|
multimod collect swim magnet articul modular nanocomposit robot magnet respons composit impart maneuver miniatur robot howev collect actuat composit robot rare achiev although conduct cooper task promis strategi accomplish difficult mission singl robot report multimod collect swim ternari nanocomposit base magnet robot capabl demand switch rectilinear translat swim rotat swim nanocomposit robot compris stiff yet lightweight carbon nanotub yarn cnti framework surround magnet polym composit mimic hierarch architectur musculoskelet system yield magnet articul multipl robot agil water swimmabl bodi length per second modular multipl robot multimod swim facilit generat regul vortic enabl novel vortex induc transport thousand float microparticl heavi semi submerg cargo control collect actuat biomimet nanocomposit robot lead versatil robot function includ microplast remov microfluid vortex control transport pharmaceut
|
D012371;D053761
|
T090;T073
|
36,347,848
|
spatial resolv gene regulatori diseas relat vulner map adult macaqu cortex singl cell approach increas knowledg cell type composit non human primat nhp detail character area specif regulatori featur remain outstand generat singl cell transcriptom chromatin access singl cell atac data cell prefront cortex pfc primari motor cortex primari visual cortex v adult femal cynomolgus monkey brain integr dataset stereo seq spatial enhanc resolut omic sequenc correspond cortic area assign topograph inform molecular state identifi area specif chromatin access site target gene includ cell type specif transcript regulatori network associ excitatori neuron heterogen reveal calcium ion transport axon guidanc gene relat special function pfc identifi similar differ adult macaqu human oligodendrocyt trajectori map genet variant gene perturb human diseas nhp cortic cell resourc establish transcriptom chromatin access combinatori regulatori landscap singl cell spatial resolv resolut nhp cortex
|
D009474;D017397
|
T023;T029;T025;T030
|
36,347,847
|
beaver dam overshadow climat extrem control riparian hydrolog water qualiti hydrolog extrem domin chemic export riparian zone dictat water qualiti major river system yet chang land use ecosystem servic alongsid grow climat variabl alter hydrolog extrem coupl impact riverin water qualiti western us warm temperatur intensifi aridif increas pair expand rang american beaver dam transform hydrolog biogeochem cycl riparian system show beaver dam overshadow climat hydrolog extrem effect water resid time oxygen nitrogen flux riparian subsurfac mountain watersh colorado usa find increas riparian hydraul gradient impos beaver dam time greater season hydrolog extrem massiv hydraul gradient increas hyporh nitrat remov relat season extrem alon drier hotter climat western us expand rang beaver magnifi impact watersh hydrolog biogeochemistri illustr ecosystem feedback climat chang alter water qualiti river system
|
D062070;D060753
|
T033;T090
|
36,347,846
|
hippo signal pathway implic human health diseas evolutionarili conserv signal network hippo pathway play crucial role regul numer biolog process thus substanti effort made understand upstream signal influenc activ hippo pathway well physiolog function cell prolifer differenti organ growth embryogenesi tissu regenerationwound heal howev dysregul hippo pathway caus varieti diseas includ cancer eye diseas cardiac diseas pulmonari diseas renal diseas hepat diseas immun dysfunct therefor therapeut strategi target dysregul hippo compon might promis approach treatment wide spectrum diseas review key compon upstream signal hippo pathway well critic physiolog function control hippo pathway addit diseas associ alter hippo pathway potenti therapi target hippo compon discuss
|
D017346;D009369
|
T191;T126;T116
|
36,347,845
|
evalu cognit disturb treatment target predictor antidepress action major depress disord neuropharm studi cognit disturb major depress disord mdd constitut critic treatment target hold promis earli predictor antidepress treatment respons yet clinic relev fulli establish therefor investig cognit perform improv cours antidepress treatment cognit perform baselin predict antidepress treatment respons neuropharm studi clinic trial id nct antidepress free patient moder sever depress episod assess comprehens cognit test batteri includ cold emot independ hot emot depend task patient test week standard antidepress treatment escitalopram flexibl dose mg perform improv across cognit domain cours antidepress treatment notabl improv independ improv mood symptom emphas cognit disturb distinct symptom therefor treatment target mdd result suggest perform singl cognit measur baselin associ later clinic respons antidepress treatment howev small cluster patient n global disturb cognit baselin exhibit poorer clinic respons week antidepress treatment suggest sever cognit disturb may delay treatment respons thus pretreat cognit perform individu test may use clinic marker treatment respons profil captur perform across differ cognit domain may use stratif patient mdd could help futur intervent trial
|
D003865;D060825
|
T048
|
36,347,844
|
fmr promot progress colorect cancer cell stabil egfr mrna depend manner fmr new reader known involv regul cancer progress howev role regulatori mechan clinic signific colorect cancer crc elus show fmr upregul crc promot prolifer metastasi crc cell vitro vivo mechan fmr recogn modif site egfr mrna key molecul cancer occurr target therapi sustain stabil maintain express depend manner therebi promot tumorigenesi metastasi crc effect fmr knockdown crc cell could abolish mettl furthermor fmr shrna plasmid carri attenu salmonella effect anti tumor effect vivo collect identifi mettlfmregfr axi progress crc novel mechan indic mettlfmregfr axi potenti target earli therapeut intervent crc progress
|
D015972;D015179
|
T045;T191
|
36,347,843
|
cell respons diagnosi amyotroph later sclerosi predict diseas progress amyotroph later sclerosi al fatal neurodegen diseas involv neuroinflamm cell infiltr central nervous system howev contribut cell respons patholog diseas fulli understood show flow cytometr analysi blood cerebrospin fluid csf sampl cohort newli diagnos al patient stockholm sweden cell phenotyp time diagnosi good predictor diseas outcom high frequenc cd foxp effector cell blood csf associ poor surviv wherea high frequenc activ regulatori treg cell high ratio activ rest treg cell blood associ better surviv besid surviv phenotyp profil cell could also predict diseas progress rate singl cell transcriptom analysi csf sampl show clonal expand cd cd cell csf characterist gene express pattern summari cell respons associ like contribut diseas progress al support modul adapt immun viabl therapeut option
|
D000690;D019636
|
T047
|
36,347,842
|
mycotoxin viriditoxin induc leukemia lymphoma specif apoptosi target mitochondri metabol inhibit mitochondri metabol offer promis therapeut approach treatment cancer identifi mycotoxin viriditoxin vdt deriv endophyt fungus cladosporium cladosporioid interest candid leukemia lymphoma treatment vdt display high cytotox potenti rapid kinet caspas activ jurkat leukemia ramo lymphoma cell contrast solid tumor cell affect much lesser extent remark human hematopoiet stem progenitor cell peripher blood mononuclear cell deriv healthi donor profound resili vdt induc cytotox likewis coloni form capac affect high concentr provid therapeut window cancer treatment intrigu vdt could direct activ mitochondri apoptosi pathway leukemia cell presenc antiapoptot bcl protein mitochondri toxic vdt confirm inhibit mitochondri respir breakdown mitochondri membran potenti releas mitochondri cytochrom c generat reactiv oxygen speci ros process dynamin like gtpase opa subsequ fission mitochondria thus vdt mediat target mitochondri oxid phosphoryl oxpho might repres promis therapeut approach treatment leukemia lymphoma without affect hematopoiet stem progenitor cell
|
D009183;D007938;D008223
|
T131;T191;T109
|
36,347,841
|
cryoem structur multimer secret ns major factor dengu hemorrhag fever dengu virus infect caus dengu hemorrhag fever dhf dengu ns multifunct intracellular dimer ns in form part viral replic complex previous studi suggest extracellular secret ns sns major factor contribut dhf exist hexam structur in well characteris sns show cryoem recombin sns exist multipl oligomer state tetramer stabl loos conform hexamer structur stabil stabl loos tetram determin conform n termin domain elong sheet roll bind anti ns fab break loos tetramer hexamer sns dimer wherea stabl tetram remain larg unbound result show detail quaternari organ differ oligomer state sns contribut toward design dengu therapeut
|
D003716;D019595;D009634;D003715
|
T019;T005;T047
|
36,347,839
|
associ hurrican exposur forecast impair birth outcom earli forecast give peopl storm path time prepar less known cost societi forecast incorrect observ studi examin birth path hurrican iren find exposur associ impair birth outcom addit warn time associ decreas preterm birth rate women experienc intens storm exposur document benefit avoid type ii forecast error larger share risk popul experienc type forecast error sever physic storm impact anticip experienc disast anticip disrupt healthcar servic delay cancel prenat care may contribut storm impact birth outcom recogn storm damag depend human respons predict storm path critic support next generat development potenti judici forecast ensur public warn system mitig rather exacerb climat damag
|
D055867;D047928;D004190
|
T070;T067;T046
|
36,347,838
|
predict crimin violent outcom psychiatri meta analysi diagnost accuraci although reduc crimin outcom individu mental ill long prioriti govern worldwid still lack object high accur tool predict event individu level predict machin learn model may provid uniqu opportun identifi highest risk crimin activ facilit person rehabilit strategi therefor systemat review meta analysi aim describ diagnost accuraci studi use machin learn techniqu predict crimin violent outcom psychiatri perform meta analys use mada meta dmetatool packag r predict crimin violent outcom psychiatr patient n registr number crd search pubm scopus web scienc articl publish languag april twenti studi includ systemat review overal studi use singl nucleotid polymorph text analysi psychometr scale hospit record rest state region cerebr blood flow build predict model studi describ systemat review nine includ present meta analysi area curv auc predict violent crimin outcom psychiatri confid interv ci partial auc averag sensit ci averag specif ci respect furthermor pool accuraci across model ci tau squar ci base avail evid suggest prospect model includ evid base risk factor identifi prior actuari model moreov need greater emphasi identifi biolog featur incorpor novel variabl explor prior literatur furthermor avail model remain preliminari prospect valid independ dataset across cultur requir prior clinic implement nonetheless predict machin learn model hold promis provid clinician research action tool improv prevent detect interven relev crime violent relat outcom psychiatri
|
D057237;D001523;D011570
|
T098;T091;T097;T048
|
36,347,837
|
antidepress effect insulin sensit medic relat improv metabol marker insulin sensit medic origin use psychiatr practic treat weight gain metabol side effect accompani use mood stabil antipsychot antidepress howev recent studi medic shown caus improv depress symptom creat potenti new indic outsid metabol regul howev still unclear whether antidepress properti medic associ improv metabol marker perform systemat search literatur follow prisma guidelin studi investig antidepress effect insulin sensit medic specif focus whether improv depress symptom connect improv metabol dysfunct major studi includ review report signific improv depress symptom follow treatment insulin sensit medic nine fifteen includ studi assess correl improv symptom chang metabol marker two nine studi found associ effect size rang r metabol variabl correl improv depress symptom includ oral glucos toler test fast plasma glucos glycosyl hemoglobin follow treatment pioglitazon metformin use insulin sensit medic clear posit impact depress symptom howev seem symptom improv may unrel improv metabol marker weight unclear addit mechan play role observ clinic improv altern option includ inflammatori neuroinflammatori chang improv cognit function brain structur futur studi insulin sensit medic measur metabol marker studi link chang metabol marker chang depress addit import use novel outcom studi chang cognit function investig acut also prophylact treatment effect
|
D008687;D014150
|
T121;T039;T109
|
36,347,836
|
neurovascular injuri associ non apoptot endotheli caspas astrogli caspas mediat inflamm contrast sensit declin retin neurovascular injuri lead caus vision loss young adult present unmet therapeut need neurovascular injuri damag homeostat communic endotheli pericyt glial neuron cell signal pathway remain establish understand mechan contribut neuron death use mous model retin vein occlus rvo use model previous discov vascular damag non apoptot activ endotheli caspas ec casp knock ec casp led decreas retin edema capillari ischemia neuron death studi aim explor role ec casp vision loss inflamm found ec casp implic contrast sensit declin induct inflammatori cytokin glial reactiv one note glial chang increas level astrogli cl caspas found activ cell intrins astrogli caspas astro casp last discov astro casp contribut capillari ischemia contrast sensit declin rvo p rvo find reveal specif endotheli astrogli non apoptot caspas role inflamm neurovascular injuri respect concomit relev contrast sensit declin
|
D015350;D012170
|
T047;T046;T041
|
36,347,835
|
myob promot tumor progress angiogenesi inhibit autophag degrad hif colorect cancer myosin b myob import singl head membran associ motor class myosin particip mani critic physiolog patholog process mount evid suggest dysregul myob express extens investig develop progress sever tumor howev function mechan myob crc angiogenesi autophagi progress remain unclear herein found express myob upregul crc tissu high express correl wors surviv overexpress myob promot prolifer migrat invas crc cell convers silenc myob suppress tumor progress vitro vivo studi indic myob inhibit autophagosom lysosom fusion potenti vegf secret crc cell promot angiogenesi mechanist myob block autophag degrad hif led accumul hif thus enhanc vegf secret promot tumor angiogenesi crc togeth studi provid novel insight role myob crc progress reveal might feasibl predict biomark promis therapeut target crc patient
|
D042461;D015179
|
T123;T191;T116
|
36,347,834
|
hnrnpu promot progress tripl negat breast cancer via rna transcript altern splice mechan tripl negat breast cancer tnbc great detriment women health due lack effect therapeut target studi employ integr genet screen identifi pivot oncogen factor heterogen nuclear ribonucleoprotein u hnrnpu requir progress tnbc elucid pro oncogen role hnrnpu induc prolifer migrat tnbc cell via associ dead box helicas ddx protein elev level hnrnpu ddx complex prohibit intron retent minichromosom mainten protein mcm pre mrna decreas nonsens mediat mrna decay activ wnt catenin signal hand hnrnpu ddx locat transcript start site tss lim domain protein lmo upregul promot transcript lmo consequ activ pik akt mtor signal data highlight synerget effect hnrnpu rna transcript splice regul cancer progress suggest hnrnpu may act potenti molecular target treatment tnbc
|
D064726
|
T191
|
36,347,833
|
feasibl home hand rehabilit use musicglov chronic spinal cord injuri random control singl blind cross studi studi regist clinicaltrialsgov nct
|
D013119;D020521
|
T047;T037
|
36,347,832
|
pipk inhibitor thz p exhibit antileukemia activ disrupt mitochondri homeostasi autophagi treatment acut leukemia challeng genet heterogen within patient leukem stem cell lscs relat drug resist frequent relaps plastic capac adapt extracellular stress mitochondri metabol autophagi play import role complic treatment genet model phosphatidylinositol phosphat kinas type protein pipk inhibit demonstr relev enzym mitochondri homeostasi autophag flux uncov cellular molecular effect thz p pan inhibitor pipk acut leukemia cell thz p reduc cell viabil induc dna damag apoptosi loss mitochondri membran potenti accumul acid vesicular organell protein express analysi reveal thz p impair autophag flux addit thz p induc cell differenti show synergist effect venetoclax primari leukemia cell lc msms base proteom analysi reveal sensit thz p associ mitochondri metabol cell cycl cell origin hematopoiet stem cell myeloid progenitor tp pathway minim effect thz p observ healthi cd cell suggest favor therapeut window studi provid insight pharmacolog inhibit pipk target mitochondri homeostasi autophagi shed light new class drug acut leukemia
|
D053719;D015470
|
T063;T191
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.