Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,307,945	spatiotempor evolut nutrient influenc factor laizhou bay past year nutrient status laizhou bay chang composit structur result anthropogen activ climat chang led sever environment problem eg eutroph organ pollut red tide better understand spatiotempor variat dissolv inorgan nitrogen din dissolv inorgan phosphorus dip eutroph laizhou bay collect histor research data conduct four cruis highest surfac din found occur autumn predomin concentr southwestern bay highest surfac dip content found winter distribut northwestern bay surfac organ pollut show estuari pollut area past year din dip eutroph shown invert u shape trend bay chang n limit p limit econom develop phytoplankton absorpt bottom miner releas factor influenc content distribut nutrient bay	D061006;D014874	T131;T083
36,307,944	trace element edibl tissu elasmobranch north aegean sea eastern mediterranean potenti risk consumpt trace element potenti bioaccumul marin organ biomagnifi toward upper level marin trophic web result rang negat effect organ elasmobranch high suscept bioaccumul trace metal consumpt human increas worldwid therefor import monitor trace metal content edibl tissu elasmobranch work reveal content trace metal edibl tissu elasmobranch speci caught greek water level permiss limit hg pb found speci analysi lifetim consumpt risk adult children use target hazard quotient thq reveal high risk two toxic substanc prioriti list substanc name hg preliminari result research requir understand better issu	D014131;D019216;D008628;D018940;D014874	T123;T121;T131;T196;T013
36,307,943	measur person damag larg scale disast review report publish japanes fire disast manag agenc great east japan earthquak tsunami studi aim identifi challeng estim person damag earli stage disast	D055866;D004190;D005390	T070;T067
36,307,942	burden communic diseas lebanon trend past decad present studi aim review main communic diseas experienc upsurg past decad lebanon highlight reason behind increas data report communic diseas till obtain lebanes ministri public health lmoph epidemiolog surveil databas tuberculosi measl mump leishmaniasi hepat main communic diseas show sharp increas past measl outbreak occur leishmaniasi outbreak mump hepat outbreak highest percentag report diseas beqaa north governor massiv influx syrian refuge lebanon togeth poor water manag system poor sanit depriv live condit limit health care access rural area might contribut upsurg communic diseas although lmoph succeed contain outbreak effort need improv identifi gap avoid futur outbreak	D009107;D006506;D003141;D012036;D008457;D007896	T047;T098
36,307,925	outcom acut myocardi infarct patient preexist physic disabl report unit state signific proport world popul live physic disabl pd requir healthcar servic risk factor cardiovascular diseas cvd hypertens diabet preval among patient pd studi compar outcom follow acut myocardi infarct ami patient preexist pd without use nation inpati sampl nis	D009203;D062645	T061;T047
36,307,914	rapid lipid laden plaqu identif intravascular optic coher tomographi imag base time seri deep learn significancecoronari heart diseas highest rate death morbid western world atherosclerosi asymptomat condit consid primari caus cardiovascular diseas accumul low densiti lipoprotein trigger inflammatori process focal area arteri lead format plaqu lipid laden plaqu contain necrot core may eventu ruptur caus heart attack stroke late intravascular optic coher tomographi iv oct imag use plaqu assess interpret iv oct imag perform visual burdensom requir high train physician accur plaqu identificationaimour studi aim provid high throughput lipid laden plaqu identif assist vivo imag offer faster screen guid decis make percutan coronari interventionsapproachan line wise classif methodolog base time seri deep learn present fulfil aim classifi train valid databas consist iv oct imag arteri section train physician expertis analysi iv oct imag provid visual evalu databas use ground truth train validationresultsthi method show accuraci sensit specif respect deep learn methodolog potenti increas speed lipid laden plaqu identif provid high throughput b scanssconclusionsthes encourag result suggest method allow high throughput video rate atherosclerot plaqu assess autom tissu character vivo imag provid faster screen assist guid decis make percutan coronari intervent	D058226;D003324;D000077321	T020;T066;T047;T046;T031
36,307,894	automat quantit measur left atrial pressur use mitral regurgit spectrum clinic studi comparison float cathet explor measur lap eq accur quantit left atrial pressur lap measur calcul equat method use mitral regurgit spectrum	D008944	T047
36,307,893	neuroprotect effect donepezil induc neurotox purpos studi investig neuroprotect effect donepezil amyloid induc neurotox possibl mechan	D018696	T121;T169
36,307,892	nationwid random control trial addit treatment isol local pancreat cancer recurr use stereotact bodi radiat therapi arcad diseas recurr main caus mortal resect pancreat ductal adenocarcinoma pdac resect patient isol local pdac recurr occur retrospect studi suggest stereotact bodi radiat therapi sbrt might lead improv local control patient potenti benefici effect surviv qualiti life nationwid random control trial addit treatment isol local pancreat cancer recurr use stereotact bodi radiat therapi arcad investig valu sbrt addit standard care patient isol local pdac recurr compar standard care alon regard surviv qualiti life outcom	D016634;D010190;D021441	T061;T191
36,307,891	effect support group leader educ program joint develop health profession patient peer leader self efficaci among leader scleroderma support group two arm parallel partial nest randomis control trial peopl rare diseas like receiv diseas educ emot practic support peer led support group way rare diseas support group deliv outsid health care system untrain leader potenti benefit may achiev harm dissemin inaccur inform may occur primari object evalu effect rare diseas support group leader educ program develop collabor research peer support group leader patient organ leader compar waitlist control peer leader self efficaci among scleroderma support group leader	D020377;D012594	T047;T041
36,307,889	deer antler extract promot tibia fractur heal mice activ bmp smad signal pathway deer antler tradit chines medicin function tonifi kidney strengthen bone often use treat orthoped diseas	D000999;D013978;D003670	T023;T015;T037
36,307,888	dual probe fluoresc spectroscopi sensit quantit alzheim amyloid patholog protein misfold promin patholog hallmark neurodegen disord includ alzheim diseas ad studi shown divers sheet rich protein deposit amyloid plaqu neurofibrillari tangl present across differ brain region might underli differ diseas phenotyp certain type aggreg might associ cognit declin conform sensit fluoresc amyloid probe abil report differ structur protein aggreg virtu shift emiss spectra defin bind affin fluoresc amyloid probe bsb mcaad diseas relev protein aggreg combin two probe examin formalin fix paraffin embed mous human brain sampl coupl quantit spectral phasor analysi dual probe stain approach reveal remark heterogen protein aggreg across sampl distinct emiss spectra consist certain type deposit present mous human brain section sensit stain imag analysi approach outperform convent immunohistochemistri detect spectral differ greater parenchyma cognit normal ad case indic subtl yet widespread proteopathi associ diseas method offer sensit object quantit examin protein misfold patholog use convent tissu section	D000544;D000686	T047;T048
36,307,887	predict risk sepsi comparison machin learn method case studi virginia hospit sepsi inflamm caus bodi system respons infect infect could result mani diseas pneumonia urinari tract infect ill symptom fever tachycardia tachypnea etc unfortun sepsi remain critic problem hospit lead mani issu increas mortal rate health care cost health care util earli detect sepsi patient help respond quick take prevent action prevent major issu main aim studi predict risk sepsi util patient demograph clinic inform ie patient gender age sever level mortal risk admit type along hospit length stay six machin learn approach logist regress lr nave bay support vector machin svm boost tree classif regress tree cart bootstrap forest use predict risk sepsi result show differ machin learn method perform term various measur instanc bootstrap forest machin learn method exhibit highest perform auc r squar svm boost tree show highest perform term misclassif rate bootstrap forest consid best machin learn method predict sepsi regard appli featur research main show superior perform effici two perform measur auc r squar	D000069550;D018805	T047;T046;T066
36,307,886	influenc factor biliari fistula radic resect hilar cholangiocarcinoma prospect cohort biliari fistula common serious complic radic resect hilar cholangiocarcinoma aim evalu influenc factor biliari fistula radic resect provid insight clinic treatment hilar cholangiocarcinoma	D018285;D018281;D001650;D002761	T047;T191
36,307,879	lpcat act independ prognost biomark correl immun infiltr hepatocellular carcinoma lysophosphatidylcholin acyltransferas lpcat overexpress multipl human tumor howev role lpcat hepatocellular carcinoma hcc understood aim explor relationship lpcat express prognosi clinicopatholog featur tumor microenviron tme immun cell infiltr immun checkpoint gene express relat signal pathway hcc furthermor also explor relationship lpcat express drug sensit hcc treatment	D006528;D008113	T191
36,307,878	lung chest wall volum vital capac manoeuvr osteogenesi imperfecta although osteogenesi imperfecta oi affect connect tissu pulmonari function might compromis thorac deform oi known restrict lung diseas spirometri provid global measur without local site restrict opto electron plethysmographi oep non invas method abl underlin alter respiratori function well ventilatori thoraco abdomin paradox spontan breath aim reconstruct thoraco abdomin surfac perform local analys trunk motion make quantit comparison trunk shape respiratori kinemat accord oi sever particular maxim inspiratori expiratori expans cross section studi studi thoraco abdomin compartment analysi adult oi patient type iii rest vital capac manoeuvr use oep also appli new method creat realist accur model perform local analys trunk motion make quantit comparison trunk shape respiratori kinemat	D035441;D010013	T023;T047
36,307,877	cystic echinococcosi northern tanzania pilot studi maasai livestock keep communiti close similar life cycl echinococcus granulosus sensu lato e granulosus sl caus cystic echinococcosi ce human taenia multicepscoenurus cerebrali caus cerebr coenurosi small rumin recent evid highlight livestock maasai communiti northern tanzania suffer increas preval cerebr coenurosi lead concern possibl concurr increas risk human ce aim studi estim preval human abdomin ce preval speciesgenotyp e granulosus sl livestock maasai communiti	D020019;D004443;D048209;D003560	T047;T190;T204
36,307,876	estrous cycl matter neurosci ovarian hormon fluctuat rodent estrous cycl human menstrual cycl known signific impact brain physiolog diseas risk yet variabl larg ignor preclin neurosci research clinic studi psychiatr practic	D030762;D012727	T032;T040
36,307,874	stimul tibial nerv repetit improv incontin parkinson electron stripe trial randomis control trial tibial nerv stimul bladder symptom parkinson diseas use self contain wearabl devic bladder symptom common parkinson diseas pd affect half individu signific impact qualiti life well implic morbid contribut fall hospit admiss treatment bladder symptom complic tendenc side effect peopl pd includ cognit impair gait instabl anti muscarin develop new better treatment therefor warrant tibial nerv stimul form neuromodul demonstr improv overact bladder symptom non neurogen cohort previous requir hospit attend aim explor use intervent use simpl devic use patient home	D053201;D010300;D004561;D014549;D000076251	T061;T047;T046;T073
36,307,873	implant collam len implant icl versus small incis lenticul extract smile low moder myopia studi protocol random non inferior trial implant collam len implant icl form foldabl posterior chamber phakic intraocular len refract surgeri general impair cornea natur accommod potenti advantag icl keratorefract laser procedur includ less induct higher order aberr hoa enhanc retin imag magnif hand small incis lenticul extract smile current one popular refract surgeri procedur also offer excel visual outcom particular eye low moder amount myopia aim studi evalu whether iclticl toric icl compar smile low moder myopia term refract outcom month post oper	D009216;D007910	T047;T074
36,307,871	osteoblast osteoclast import switch tumour cell dormanc bone metastasi bone metastasi occur tumour cell dissoci primari tumour enter circul circul tumour cell ctcs colon site bone dissemin tumour cell dtcs bone marrow seem particular dormanc induc environ dtcs yet mechan dormanc initi reactiv interact within bone marrow elucid intrigu evid suggest dormanc revers state switch depend presenc various bone marrow resid cell particular osteoclast osteoblast becom clear two cell contribut regul dormant tumour cell bone direct interact indirect secret factor involv mechan includ tgf signal wnt signal axi notch pathway etc detail review specif focus ascertain dynam interact tumour cell dormanc bone remodel addit highlight role inflammatori cytokin cell cell communic also discuss potenti clinic relev remodel bone marrow nich control dormant tumour cell understand uniqu role osteoclast osteoblast regul tumour dormanc bone marrow provid new insight prevent treat tumour bone metastasi	D001859;D009360	T191;T025
36,307,869	myocardi infarct size independ predictor intramyocardi haemorrhag acut reperfus myocardi ischaem rat previous studi haemorrhag occur larg infarct size studi found moder correl extent necrosi haemorrhag extent infarct size studi limit studi aim find correl intramyocardi haemorrhag imh myocardi infarct mi myocardi oedema small larg size mi mr scanner	D003287;D009203	T047;T130
36,307,868	reemerg pathogen autoantibodi produc b cell clone myasthenia gravi follow b cell deplet therapi myasthenia gravi mg autoantibodi mediat autoimmun disord neuromuscular junction small subset patient mg autoantibodi target muscl specif tyrosin kinas musk musk mg patient respond well cd mediat b cell deplet therapi bcdt achiev complet stabl remiss howev relaps often occur understand immunomechan under relaps studi autoantibodi produc b cell cours bcdt develop fluoresc label antigen enrich musk specif b cell valid novel nalm cell line engin express human musk specif b cell receptor b cell million differ sampl collect nine musk mg patient screen musk specif success isol two musk specif igg subclass express plasmablast two patient experienc relaps bcdt induc remiss human recombin musk mab generat valid bind specif character molecular properti mab strong musk binder recogn ig like domain musk show pathogen capac test acetylcholin receptor achr cluster assay presenc persist clonal relat musk specif b cell clone investig b cell receptor repertoir trace uniqu clone deriv longitudin sampl collect two patient clonal variant detect multipl timepoint span five year reemerg bcdt mediat remiss predat diseas relaps sever month find demonstr reservoir rare pathogen musk autoantibodi express b cell clone surviv bcdt reemerg circul prior manifest clinic relaps overal studi provid mechanist understand musk mg relaps valuabl candid biomark relaps predict	D020794;D009157	T047;T126;T116;T192
36,307,867	long noncod rna irf associ pest des petit rumin infect pest des petit rumin ppr acut high contagi diseas long signific threat small rumin product worldwid howev molecular mechan under host pprv interact remain unclear long noncod rnas lncrnas regul ppr virus pprv infect rare report far first demonstr pprv infect induc obvious innat immun respons caprin endometri epitheli cell eec h post infect hpi moi subsequ determin pprv infect associ signific differenti express sde lncrnas name upregul downregul lncrnas caprin eec compar mock control cell hpi use deep sequenc technolog import bioinformat preliminarili analys reveal de lncrnas close relat immun respons furthermor identifi system lncrnas relat immun respons focus role lncrna irf regul innat immun respons interest found irf potent posit regul ifn isg product signific inhibit pprv replic host cell addit data reveal irf posit correl potenti target gene irf enhanc activ irf express isg interact irf studi suggest irf could new host factor target develop antivir therapi pprv infect	D029021;D062085;D018107;D015511	T123;T047;T005;T114
36,307,864	raba gtpase regul epitheli mesenchym transit modul rac activ epitheli mesenchym transit emt critic underpin process cancer progress recurr resist drug treatment identif new regul emt could lead develop effect therapi improv outcom advanc cancer current studi discov use varieti vitro vivo approach raba function essenti emt relat manifest stem invas properti consist raba suppress abolish cancer cell self renew tumor form abil term downstream signal found raba regul emt achiev control activ rac gtpase introduc activ rac effici rescu emt gene express invas tumor format suppress raba knockdown vitro vivo cancer model summari studi identifi raba rac signal axi key regulatori mechan process emt cancer progress suggest potenti therapeut approach control process	D020830;D001943	T191;T126;T116
36,307,863	differenti tracheobronchi involv granulomatosi polyangi relaps polychondr chest ct cohort studi patient tracheobronchi involv differenti diagnosi granulomatosi polyangi gpa relaps polychondr rp challeng aim studi describ characterist airway abnorm chest comput tomographi ct patient gpa rp determin whether specif imag criteria could use differenti	D011081;D014890	T047
36,307,862	multicent random control trial compar effect starc sud skill train affect regul cultur sensit approach versus treatment usual trauma expos refuge substanc use problem refuge often report high level psycholog distress due traumat experi flight well mani post migrat stressor refuge hazard substanc use exist substanc use disord sud particular vulner group prevent therapeut measur avail aim studi investig effect integr cultur sensit group therapi approach starc sud improv affect regul refuge substanc relat problem	D012036;D013313;D019966;D016739	T033;T098;T048
36,307,861	season fluctuat babesia bigemina rhipicephalus microplus brangus nellor cattl rear cerrado biom brazil tick rhipicephalus microplus ixodida ixodida canestrini caus substanti econom health loss cattl product main vector babesia bigemina piroplasmida babesida smith kilborn babesia bigemina respons tick born diseas known babesiosi caus hemolyt anemia fever death studi report investig relationship number tick per anim number b bigemina cytochrom b gene cbisg copi blood brangus nellor cattl rear without acaricid treatment brazilian cerrado biom year period	D001403;D048494;D001404;D002418	T047;T204
36,307,860	evalu cross platform compat dna methyl base glucocorticoid respons biomark identifi blood base dna methyl pattern minim invas way detect biomark predict age characterist certain diseas condit well respons immunotherapi microarray platform continu evolv increas scope cpgs measur new discoveri base recent platform version compar avail data previous version platform unknown neutrophil dexamethason methyl index ndmi blood base dna methyl biomark built illumina methylationep k array measur epigenet respons dexamethason dex synthet glucocorticoid often administ inflamm compar ndmi one built use data illumina methyl k ndmi	D019175;D005938	T125;T039;T044;T109
36,307,859	applic exom sequenc prenat diagnosi fetal structur anomali clinic experi lesson learn cohort fetus exom sequenc es becom wide avail prenat diagnosi howev data clinic util integr clinic manag remain limit practic herein report experi implement prenat es pes larg cohort fetus anomali detect ultrasonographi use hospit base hous multidisciplinari team mdt facilit three step genotyp driven follow phenotyp driven analysi framework	D059472;D016216	T060;T028
36,307,858	high definit transcrani direct current stimul hd tdcs augment therapi late life depress lld suboptim respons treatment studi protocol doubl blind random sham control trial late life depress lld poorer prognosi higher relaps rate younger adult one third patient lld show suboptim respons antidepress therapi lld associ signific impair cognit daili function studi evalu therapeut effect high definit transcrani direct current stimul hd tdcs depress cognit symptom lld current random control trial assess efficaci hd tdcs augment therapi antidepress compar sham control subject lld	D065908	T061
36,307,857	social accept livestock administ endectocid malaria control vhemb district limpopo provinc south africa malaria continu lead caus morbid mortal africa convent malaria control strategi indoor residu spray insecticid treat bed net limit effect malari vector consequ develop altern supplementari strategi requir one potenti strategi use livestock administ endectocid control vector mosquito feed outdoor livestock howev sinc strategi requir support local communiti livestock owner consent anim treat implement agre affect communiti aim studi assess social accept use livestock administ endectocid malaria endem villag vhemb district limpopo provinc south africa malaria incid high	D008288;D000852;D007306	T131;T047;T204
36,307,855	new insight role lipid metabol relat protein rheumat heart valv diseas aim studi determin express lipid metabol relat protein rheumat heart valv diseas rhvd	D012214;D006349	T047
36,307,853	impact age cerebrospin fluid space high convex medial subarachnoid space decreas age impair cerebrospin fluid csf dynam may contribut pathophysiolog neurodegen diseas play crucial role brain health older peopl nonetheless age relat chang well elucid disproportion enlarg subarachnoid space hydrocephalus desh neuroimag phenotyp idiopath normal pressur hydrocephalus origin impair csf dynam close associ age studi aim investig pathophysiolog desh determin age relat chang csf dynam	D006850	T047
36,307,852	molecular surveil anti malari drug resist genet divers plasmodium falciparum chloroquin sulfadoxin pyrimethamin withdraw quibdo colombia resist anti malari drug associ polymorph target gene surveil molecular marker import detect emerg mutat associ drug resist signal recov sensit anti malari previous use	D000962;D016778	T121;T047
36,307,851	preconcept fear childbirth experi need women fear childbirth first pregnanc although earli case studi indic fear childbirth predat woman first pregnanc concept preconcept fear childbirth larg unexplor studi report preval preconcept fear childbirth found higher level preval estim pregnant popul howev littl known women fear childbirth becom pregnant aim qualit studi give voic experi often neglect group women	D036801;D036861	T061;T040
36,307,850	polici stewardship landscap nation health research system look like develop countri like iran qualit studi health research system hrs import nation prioriti requir systemat function approach evalu hrs iran develop countri identifi challeng reveal stewardship relat role whole system oper well studi aim assess hrs term stewardship function highlight enhanc point	D003906;D006078	T064;T080
36,307,849	intent chang polici awar health knowledg relat chang dietari intak follow sugar sweeten beverag tax south africa studi april south africa implement health promot levi hpl one first sugar sweeten beverag ssb tax base gram sugar beyond gml object studi examin whether psycholog construct tax awar ssb knowledg ssb risk percept intent reduc ssb intak associ tax beverag intak whether chang pre post tax whether modifi effect hpl	D000080845	T168
36,307,845	safeti studi intraop radiat therapi follow stereotact bodi radiat therapi multi agent chemotherapi treatment local pancreat adenocarcinoma studi protocol phase trial local pancreat adenocarcinoma carri poor prognosi even aggress therapi patient may develop locoregion diseas first site failur may role intensif local therapi radiat therapi radiat dose escal pancreat cancer limit proxim tumor duodenum howev duodenum remov whippl procedur allow opportun dose escal intraop radiat therapi iort although prior studi shown potenti benefit iort pancreat cancer studi util ablat dose biolog effect dose bed gy furthermor optim radiat target volum set unclear increas interest triangl volum tv border celiac axi superior mesenter arteri common hepat arteri portal vein superior mesenter vein dissect area advoc surgeon heidelberg contain extra pancreat perineur lymphat tract may harbor microscop diseas risk mediat local failur interest recent analysi institut indic near local failur occur tv therefor purpos protocol evalu safeti deliv ablat radiat dose tv iort follow neoadjuv chemotherapi stereotact bodi radiat therapi sbrt	D010190;D000230;D016634	T061;T191
36,307,844	famili build mean qualit explor new definit uk base studi import improv men women knowledg sexual reproduct health emphasis numer global health polici fertil awar literatur highlight disproportion higher number articl relat pregnanc prevent compar pregnanc plan justifi mani context howev recent concert effort improv fertil awar warrant closer investig basic reproduct health terminolog object studi explor particip view famili build provid definit	D005193;D005298	T071;T032;T055;T040;T033;T062;T058
36,307,843	studi knowledg attitud practic regard patient educ hypertens among communiti pharmacist china prevent treatment hypertens patient educ import measur improv awar rate control rate patient profession geograph advantag communiti pharmacist enabl play import role patient educ hypertens purpos studi understand situat patient educ hypertens conduct chines communiti pharmaci put forward measur accord problem	D006973;D003157	T047;T058
36,307,841	mical substrat ubiquitinas trim regul tumorigenesi colorect cancer molecul interact casl like protein mical believ regul cytoskeleton dynam tight junction format neurit outgrowth howev biolog role under mechan colorect cancer crc remain larg elus	D015972;D015179	T045;T191
36,307,840	vitamin b defici may play etiolog role atroph glossiti grade clinic case control studi exist studi report signific associ atroph glossiti ag hematin defici includ iron folat vitamin b defici howev find inconsist ag grade partial complet atrophi still unclear whether hematin defici associ grade ag	D005928;D006397;D020138;D014806;D000740	T121;T047
36,307,839	healthcar system learn look tension innov process systemat literatur review scholarship innov process healthcar system lack depth appreci tension tension often revolv around barrier result individu assess priorit guid action eventu overcom barrier order develop differenti understand tension role healthcar innov process paper aim shed light multifacet way tension emerg dealt hinder time facilit innov process	D003695;D006076	T092;T058;T093
36,307,837	short term efficaci advers effect collagenas clostridium histolyticum inject percutan needl fasciotomi limit fasciectomi treatment dupuytren contractur network meta analysi random control trial dupuytren contractur dc chronic debilit fibroprolif disord common treatment option includ collagenas clostridium histolyticum inject ci percutan needl fasciotomi nf limit fasciectomi lf superior one specif treatment remain controversi studi aim assess short term efficaci safeti ci nf lf treatment dc	D004387;D004204	T047;T037
36,307,836	maintain activ ankylos spondyl patient treat tnfi andor nsaid least week cross section studi brazil aim studi evalu diseas activ among patient axial spondyloarthr treat tumor necrosi factor inhibitor tnfi andor nonsteroid anti inflammatori drug nsaid least week privat outpati set brazil	D013167	T047
36,307,835	tubulovil adenoma high grade dysplasia vulva harbor high tumor mutat burden cancer associ mutat case report vulvar cancer rare diseas account approxim gynecolog malign primari adenocarcinoma intestin type vulva precancer lesion extrem rare detail regard origin evolut relat genet mutat unknown treatment option cancer defin	D000236;D014846;D000230;D007414;D011230	T191
36,307,834	risk factor air leakag invas mechan ventil pediatr intens care unit studi aim investig air leakag invas mechan ventil imv pediatr intens care unit picu explor potenti risk factor	D012128;D012131	T047;T046
36,307,833	plasmodium falciparum communiti preval health seek behaviour rural sussundenga district mozambiqu impact nation direct malaria control intervent hing understand malaria transmiss prevent communiti level decis seek care health seek behaviour provid valuabl insight knowledg malaria access care efficaci malaria case manag thus far studi focus central mozambiqu aim describ communiti level plasmodium falciparum preval health seek behaviour among resid sussundenga mozambiqu rural villag manica provinc high malaria incid report sussundenga sede health centr rhc	D000962;D016778;D008288	T121;T047
36,307,832	transcriptom analysi sputum cell reveal two distinct molecular phenotyp asthma chronic obstruct pulmonari diseas overlap elder littl known pathogenesi asthma chronic obstruct pulmonari diseas copd overlap aco studi examin molecular phenotyp aco elder	D029424;D001249	T047
36,307,831	introduct modifi degan classif specifi treatment algorithm fractur anterior process calcaneus fractur anterior process calcaneus often miss treatment result receiv littl attent current literatur aim studi specifi treatment algorithm modif degan classif	D002111;D050723	T023;T037
36,307,830	improv pediatr covid vaccin uptak use mhealth tool moveup studi protocol random control trial coronavirus diseas covid vaccin demonstr excel effect infect sever diseas death howev pediatr covid vaccin rate lag among individu rural medic underserv communiti research object current protocol determin effect vaccin communic mobil health mhealth applic app parent decis vaccin children covid	D000086382;D017216;D014612	T129;T121;T116;T067;T047;T058
36,307,828	sctam seq enabl target high confid analysi dna methyl singl cell singl cell dna methyl profil current suffer excess nois andor limit cellular throughput develop sctam seq target bisulfit free method profil cpgs cell per experi dropout rate low demonstr sctam seq resolv dna methyl dynam across b cell differenti blood bone marrow identifi intermedi differenti state previous mask sctam seq addit queri surfac protein express thus enabl integr singl cell dna methyl inform cell atlas data summari sctam seq high throughput high confid method analyz dna methyl singl cpg resolut across thousand singl cell	D019175;D059014	T063;T059;T044
36,307,827	proxim fibular osteotomi versus high tibial osteotomi treat knee osteoarthr systemat review meta analysi knee osteoarthr koa varus align medial space stenosi common degen disord elder realloc forc bear medial later compart anti varus osteotomi includ high tibial osteotomi hto proxim fibular osteotomi pfo correct mechan line lower extrem use surgic method allevi abras medial cartilag reliev pain pfo base non uniform settlement theori cut small section proxim fibula ie fibula head break fibula weaken support later tibial plateau last reduc gap later side knee joint offset knee varus deform caus weight bear conduct systemat review meta analysi compar clinic outcom pfo versus hto intervent	D020370	T047
36,307,826	toler eribulin correl polymorph neuropathi unselect popul femal patient metastat breast cancer result multicent singl arm phase iv painter studi metastat breast cancer mbc incur diseas treatment focus prolong patient pts overal surviv os improv qualiti life eribulin microtubul inhibitor increas os pre treat mbc pts common advers event ae asthenia neutropenia peripher neuropathi pn	D001943;D010523;D009503	T047;T191
36,307,825	transcriptom metabolom analys provid insight influenc polylysin synthetas metabol streptomyc albulus poli l lysin pl main secondari metabolit streptomyc albulus wide use food industri polylysin synthetas pls last enzym pl biosynthet pathway previous studi reveal pls overexpress albulus cicc result effici product pl studi pls gene knockout strain initi construct genom transcriptom metabolom approach integr studi effect high express knockout pls gene express metabolit synthesi albulus high express pls result signific differenti express gene deg known differenti metabolit wherea inactiv pls result signific deg known differenti metabolit express gene negat posit associ pls express respect subsequ influenc mechan high express inactiv pls pl biosynthet pathway elucid twelv metabolit decreas yield high express strain pls increas product pls knockout strain identifi result demonstr influenc pls metabol albulus present work provid theoret basi improv product capac pl mean metabol engin develop bioactiv substanc deriv albulus	D011107;D013302	T007;T116
36,307,824	type lymphomatoid papulosi pityriasi lichenoid et varioliformi acuta like featur child parvovirus infect controversi diagnosi spectrum lymphoid prolifer case report literatur review lymphomatoid papulosi lyp rare condit pediatr lyp histolog type report children differenti diagnosi lyp spectrum lymphoid prolifer remain controversi	D000086382;D017731;D010322;D017514	T047;T191;T067
36,307,822	chang cross section area vastus mediali obliqu patient recurr patellar disloc treat tibial tubercl transfer combin medial patellofemor ligament reconstruct axial ct investig chang cross section area csa vastus mediali obliqu vmo patient recurr patellar disloc rpd treat tibial tubercl transfer combin medial patellofemor ligament mpfl reconstruct imag method guid clinic treatment rehabilit	D031222;D057071;D004204;D007593	T033;T037;T030
36,307,821	anca associ vascul cardiac valv veget two teenag male two case report literatur review anti neutrophil cytoplasm antibodi anca associ vascul term use describ system vasculitid affect small medium size blood vessel granulomatosi polyangi gpa type anca associ vascul aav rare children estim preval per million even rare manifest cardiac abnorm secondari anca associ vascul pediatr popul	D056648;D014890	T047
36,307,820	methodolog protocol conduct scope review health research onbywith indigen women north america indigen women north america experi multipl inequ term health well compar non indigen women indigen men effort understand health dispar surg research field indigen women health well last year object studi conduct scope review current research field determin theoret framework use studi topic indigen women health well north america	D003695;D044382	T058;T098;T093
36,307,819	distribut lipid level preval hyperlipidemia data nhane lipid lower therapi import distribut lipid level incid hyperlipidemia may vari differ subgroup popul aim explor distribut lipid level preval hyperlipidemia subpopul subgroup factor includ age sex race smoke status	D006949;D015228	T033;T047
36,307,818	neonat ankyloglossia interfer growth infant first month life case seri nest cohort studi ankyloglossia common report one major caus breastfeed difficulti lack research infant growth latch perform clinic measur	D000072676	T019
36,307,817	use nomin group techniqu identifi barrier facilit prevent hiv use combin day pre exposur prophylaxi medic opioid use disord prevent hiv transmiss among peopl inject drug pwid key element us end hiv epidem strategi includ pre exposur prophylaxi prep medic opioid use disord moud lead decreas hiv transmiss moud social health benefit meanwhil prep addit hiv prevent advantag sexual risk inject stimul howev medic often prescrib differ set requir multipl visit initi strategi integr servic ie co prescript offer day prescript may reduc demand patient could benefit	D065129;D019380;D015819;D015658;D009293	T061;T121;T047;T048
36,307,816	global inequ covid vaccin coverag among health care worker health care worker hcws forefront covid respons high risk infect result prioriti group covid vaccin paper present global pattern covid vaccin coverag among hcws hcws priorit identifi factor associ earli vaccin coverag	D000073887;D000086382	T058;T067;T047
36,307,815	effect medial calcar support proxim humer fractur treat lock plate studi report mix result import medial calcar support treatment proxim humer fractur purpos studi compar radiograph function outcom patient displac proxim humer fractur vari level medial support	D012784;D006810	T037
36,307,814	identif novel fulli human anti toxic shock syndrom toxin tsst singl chain variabl fragment antibodi avert tsst induc mitogenesi cytokin secret staphylococc superantigen virul factor help pathogen escap immun system develop infect toxic shock syndrom toxin tsst one studi superantigen whose role toxic shock syndrom particular disord demonstr inhibit tsst product antibiot target tsst monoclon antibodi might one best strategi prevent tsst induc cytokin storm follow lethal	D057127	T129
36,307,812	improv periop manag surgic set trauma surgeri approach periop manag surgic instrument implant compris set trauma surgeri identifi complex resourc intens activ due non standard inventori redund surgic instrument unnecessari steril cycl intellig trauma care program aim improv periop manag therebi reduc environment impact util standard inventori steril implant portfolio barcod enabl digit safeti certif digit restock servic	D013242;D013525	T058;T074
36,307,811	explor barrier facilit integr polici formul implement famili plan urban develop programm nigeria peopl live urban area rural communiti nigeria urban develop ud requir urgent polici programmat attent although popul factor identifi import achiev nation develop goal evid suggest meet famili plan fp reproduct health rh need vulner urban popul serv import recip achiev popul growth rate consist build sustain habit prosper urban set fp remain neglect subject ud initi nigeria studi explor barrier facilit achiev integr polici formul implement fp ud programm nigeria	D005193;D014506	T033;T068;T058
36,307,810	compar analysi prognosi extern beam radiat therapi ebrt ebrt plus brachytherapi glioblastoma multiform seer popul base studi radiotherapi one effect way treat glioblastoma multiform gbm aim explor prognost differ extern beam radiotherapi ebrt ebrt combin brachytherapi ebrt bt	D001918;D005909	T061;T191
36,307,809	psychometr evid percept scale covid vaccin process peruvian dentist preliminari valid current pandem context dental profession greater occup risk due healthcar activ place expect vaccin mean protect time hope immun process safe reliabl comfort give greater peac mind return work therefor aim present studi develop provid preliminari valid scale measur percept covid vaccin process peruvian dental profession	D000086663;D000086382	T200;T047;T067
36,307,808	antioxid brain tumor current therapeut signific futur prospect brain cancer regard among deadliest form cancer worldwid distinct tumor microenviron inher characterist brain tumor cell virtual render resist major convent advanc therapi oxid stress os key disruptor normal brain homeostasi involv carcinogenesi differ form brain cancer thus antioxid may inhibit tumorigenesi prevent os induc various oncogen factor antioxid hypothes inhibit cancer initi endors dna repair suppress cancer progress creat energi crisi preneoplast cell result antiprolif effect effect refer chemoprevent effect mediat antioxid mechan addit antioxid minim chemotherapi induc nonspecif organ toxic prolong surviv antioxid also support prooxid chemistri demonstr chemotherapeut potenti particular high pharmacolog dose trigger os promot free radic product essenti activ cell death pathway grow bodi evid also reveal role exogen antioxid adjuv abil revers chemoresist review explain influenc differ exogen endogen antioxid brain cancer refer chemoprevent chemotherapeut role role antioxid metabol reprogram influenc downstream signal event induc tumor suppressor gene mutat critic discuss final review hypothes pro antioxid role involv anticanc mechan antioxid molecul kill neoplast cell inhibit tumor recurr follow convent cancer treatment requir pro antioxid effect exogen antioxid brain tumor treatment differ condit critic discuss along reason behind conflict outcom differ report final also mention influenc factor regul pharmacolog exogen antioxid brain cancer treatment conclus achiev consist clinic outcom antioxid treatment brain cancer rigor mechanist studi requir respect type form stage brain tumor concomit treatment regimen also need adequ consider	D000975;D001932	T123;T121;T191;T039;T044
36,307,807	facil process adip acid product high yield oxid hexanediol use rest cell gluconobact oxydan adip acid aa one import industri chemic use main product nylon also make polyurethan plastic unsatur polyest resin recent compon biodegrad polyest poli butylen adip terephthal pbat main rout aa product util benzen feedstock generat copious amount greenhous gas henc altern clean product rout aa renew bio base feedstock draw increas attent earlier report potenti gluconobact oxydan cell oxid hexanediol potenti biobas diol aa	D020600;D000074382	T197;T007
36,307,806	food insecur eat habit lebanes children age year covid pandem socioeconom crisi nation studi food insecur lack access nutriti healthi food due econom financi insuffici food insecur expect higher difficult time lebanon face mani financi polit econom health debat present studi aim find preval food insecur among lebanes children covid pandem correl	D000086382	T047;T067
36,307,805	erythropoietin plga peg local treatment promot function recoveri neurovascular regener peripher nerv injuri traumat peripher nerv injuri tpni major medic problem univers accept pharmacolog treatment hypothes encapsul pro angiogen erythropoietin epo amphiphil plga peg block copolym could serv local control releas drug deliveri system enhanc neurovascular regener nerv injuri	D059348;D020426;D004921;D000071576	T121;T116;T037;T125;T047
36,307,804	polygen associ glomerular filtrat rate declin world trade center respond factor associ estim glomerular filtrat rate egfr declin low risk adult remain relat unknown hypothes polygen risk score prs associ egfr declin	D051436;D003920	T047
36,307,803	associ metabol factor radiograph knee osteoarthr earli diseas cross section studi individu knee pain metabol factor shown associ sever radiograph knee osteoarthr rkoa howev knowledg need earli clinic knee osteoarthr koa aim studi associ metabol factor radiograph knee osteoarthr oa individu knee pain second aim studi associ metabol factor rkoa normal bmi overweightobes respect	D020370;D024821	T047
36,307,802	spectral domain optic coher tomographi characterist cystic retin tuft investig characterist cystic retin tuft crts widefield spectral domain optic coher tomographi	D041623;D012167	T060;T047
36,307,801	similar cardiometabol risk factor among random male femal pair larg observ studi japan previous observ studi shown similar cardiometabol risk factor spous still possibl result reflect age similar spous rather environment factor spous eg cohabit effect clarifi import mate cardiometabol risk factor similar environment factor necessari examin whether observ random male femal pair maintain age spousal pair studi aim determin whether similar found spousal pair cardiometabol risk also observ random male femal pair	D003924;D006973;D002318	T047
36,307,800	transpos element expans low level pirna silenc grasshopp may caus genom gigant transpos element tes liken parasit genom reproduc move ceaseless host continu enlarg host genom howev piwi interact rna pirna pathway defend anim genom harm consequ te invas impos small rna mediat silenc compar te activ two grasshopp speci differ genom size acridida locusta migratoria manilensisc pg angaracri rhodopac pg ascertain influenc pirna	D006110;D005877	T047;T204
36,307,799	causal associ circul amino acid blood pressur mendelian random studi circul level amino acid associ blood pressur bp observ studi howev causat associ hypothes difficult prove human studi aim use two sampl mendelian random analys evalu potenti causal associ circul level amino acid bp risk hypertens	D057182;D006973	T062;T047
36,307,798	enabl mental health task share collect case studi undergradu clinic associ train programm south africa shortag human resourc need deliv mental health servic like exacerb covid due mental health workforc shortag task shift task share approach implement number countri clinic associ mid level cadr work supervis medic practition could play role deliv mental health servic clear adequ prepar studi explor mental health curriculum content undergradu clinic associ train programm south africa view key inform adequaci train mental health	D008603;D000086382	T047;T067;T041
36,307,797	lipid product lignocellulos biomass use engin yarrowia lipolytica strain util industri wast feedstock microbi base process one high potenti approach develop sustain environment benefici valuabl bioproduct inter alia lipid rye straw hydrolys possibl renew carbon sourc bioconvers contain larg amount xylos inaccess wild type yarrowia lipolytica strain although oleagin yeast possess crucial gene xylos util necessari induc metabol pathway effici growth xylos mix sugar agricultur wast either way biotechnolog product singl cell oil sco lignocellulos hydrolys requir yeast genom modif adapt suboptim environ	D025062	T004
36,307,796	develop valid famili function measur aborigin torr strait island adult famili kinship network key aspect cultur aborigin torr strait island peopl australia intrins connect good health wellb cultur knowledg exchang howev despit known import famili kinship network aborigin torr strait island cultur move toward famili centr approach healthcar servic provis valid nation measur famili function aborigin torr strait island peopl valid tool measur famili function necessari order better understand foster good famili function inform develop program healthcar intervent	D044468;D006303	T058;T098
36,307,795	preoper serum ca predict postop pancreat fistula pdac patient retrospect analysi singl institut postop pancreat fistula popf critic complic pancreatectomi patient pancreat ductal adenocarcinoma pdac recent paper report serum carbohydr antigen ca level predict long term prognosi investig whether preoper serum ca level associ popf pdac patient	D021441;D010190	T191
36,307,794	assess impact formal prepar activ perform univers clinic aptitud test ucat nation studi previous studi shown perform univers clinic aptitud test ucat associ measur candid socio econom advantag parent occup type school attend possibl access prepar support materi may part explain associ paper determin whether use formal prepar resourc associ higher ucat score whether differ use prepar resourc exist socio demograph group	D012577;D013337	T097;T073;T093
36,307,793	explor ident develop bud neuroscientist postgradu level mix method studi perspect alumni academ neurosci repres one excit frontier scientif research howev given recenc neurosci disciplin inter multi disciplinari natur lack educ research brain scienc train absenc nation global benchmark numer neurosci subfield develop academ neuroscientist ident across career stage remain obfusc neurosci predomin taught undergradu level present postgradu special accept graduat wide rang primari disciplin	D013334	T081;T098
36,307,792	worldwid cancer statist adult year old systemat analysi global burden diseas studi cancer becom one major killer human due number peopl age increas popul age aim studi analys incid mortal rate peopl cancer type countri region well trend	D000071219;D009369	T081;T191
36,307,791	one year outcom polym free amphilimus elut stent versus durabl polym zotarolimus elut stent patient diabet mellitus meta analysi diabet mellitus dm cardiovascular diseas often co exist today percutan coronari intervent pci prefer revascular procedur major patient coronari arteri diseas polym free amphilimus elut stent ae repres novel elut technolog current era drug elut stent analysi aim systemat compar cardiovascular outcom associ polym free amphilimus elut stent ae versus durabl polym zotarolimus elut stent zes treatment patient dm	D054855;D062645;D002317;D003324;D003920	T061;T121;T047;T074
36,307,790	gelma mxene hydrogel nerv conduit microgroov spinal cord injuri repair repair spinal cord injuri sci depend microenviron improv reconnect injur axon regener neuron fabric gelma mxene hydrogel nerv conduit electr conduct intern face longitudin groov explor function sci repair found result groov gelma mxene hydrogel could effect promot neural stem cell nscs adhes direct prolifer differenti vitro addit gelma mxene conduit load nscs gmn implant injur spinal cord site effect repair capabl complet transect sci demonstr gmn group show remark nerv recoveri signific higher bbb score comparison group therefor gmn microgroov structur load nscs promis strategi treat sci	D013119;D058953	T025;T037
36,307,789	high preval chronic malnutrit indigen children year age chimborazo ecuador multicaus analysi determin despit multipl initi implement reduc stunt ecuador continu public health problem signific preval one affect group rural indigen popul studi aim analyz preval chronic malnutrit indigen children year age associ health determin focus one territori highest preval stunt	D044342	T047
36,307,788	case control studi cypb gene polymorph suscept gastric cancer chines han popul china gastric cancer gc one common malign tumor studi aim explor relationship rs rs rs polymorph cypb suscept gc chines han popul	D013274	T191
36,307,787	motion artefact reduct coronari ct angiographi imag deep learn method aim studi investig abil pixel pixel generat adversari network gan remov motion artefact coronari ct angiographi ccta imag	D016477;D000077321	T068;T066
36,307,786	associ nutrient pattern hyperuricemia mediat analysi involv obes indic nhane diet long hypothes play import role hyperuricemia weight gain factor strong associ rise serum urat aim clarifi mediat role obes relationship diet hyperuricemia determin whether weight loss diet effect way prevent hyperuricemia	D033461	T047
36,307,785	examin influenc correl differ quantil surviv time infant mortal bangladesh sever studi identifi factor influenc infant mortal best knowledg studi assess factor consid unequ effect differ surviv time infant mortal bangladesh studi examin set covari behav differ quantil surviv time relat infant mortal	D007226;D001721	T081;T079
36,307,784	finit element analys later condyl fractur fixat paediatr regard configur kirschner wire studi aim discov stabl outcom among differ kirschner wire k wire configur fixat later condyl fractur milch type ii differ load stress use finit element analys fea	D006810;D010372	T091;T037
36,307,783	caus mortal risk older patient femor neck fractur mortal rate hip fractur high howev year mortal rate femor intertrochanter fractur femor neck fractur differ gibson smith klop c elder pj wels pm van schoor n leufken hg et al osteoporo int although type hip fractur previous real world singl center prospect cohort studi show older age high charlson comorbid index score risk factor femor intertrochanter fractur addit therapi zoledron acid mg aclasta protect factor li xp zhang p zhu sw yang mh wu xb jiang xy j orthop surg res wish determin risk factor caus mortal femor neck fractur patient	D005265;D006620;D005264	T037
36,307,782	associ statin progress osteoarthr featur magnet reson imag predomin pre radiograph cohort vancouv longitudin studi earli knee osteoarthr valseko cohort studi evalu effect statin use osteoarthr oa incidenceprogress use magnet reson imag mri popul base cohort predomin pre radiograph knee oa	D020370;D019161;D054850;D002358	T121;T047;T024;T109
36,307,781	effici secretori product prolinealanineserin pas biopolym corynebacterium glutamicum yield monodispers biolog altern polyethylen glycol peg pas biopolym recombin polypeptid compris small uncharg l amino acid pro ala andor ser resembl wide use poli ethylen glycol peg term pronounc hydrophil likewis random chain behaviour physiolog solut result strong expand hydrodynam volum thus apart use fusion partner biopharmaceut achiev prolong half life vivo pas biopolym appear attract substitut peg poor degrad chemic polym mani area prerequisit wide applic pas biopolym afford cost establish high effici biotechnolog product corynebacterium glutamicum serv well character bacteri host organ	D011392;D048230	T123;T007;T116
36,307,780	microaerob metabol lactat propion enhanc vitamin b product propionibacterium freudenreichii propionibacterium freudenreichii use biotechnolog applic produc vitamin b although cultur main anaerob condit microaerob condit great enhanc biomass format p freudenreichii sinc b yield may coupl biomass format microaerob condit show great potenti increas b yield p freudenreichii	D000070002	T007
36,307,779	digit support patient center asynchron outpati follow rheumatoid arthriti explor qualit studi steadili increas demand decreas number rheumatologist push current rheumatolog care limit long travel time poor access rheumatologist present particular challeng patient need adapt digit support patient center flexibl model care could contribut maintain high qualiti patient care qualit studi embed random control trial telera investig new model care consist use medic app epro electron patient report outcom self administ crp c reactiv protein test joint self examin rheumatoid arthriti ra patient qualit studi aim explor experi ra patient rheumatolog staff regard current care new care model	D001172;D012219	T047;T091

36,307,945

spatiotempor evolut nutrient influenc factor laizhou bay past year nutrient status laizhou bay chang composit structur result anthropogen activ climat chang led sever environment problem eg eutroph organ pollut red tide better understand spatiotempor variat dissolv inorgan nitrogen din dissolv inorgan phosphorus dip eutroph laizhou bay collect histor research data conduct four cruis highest surfac din found occur autumn predomin concentr southwestern bay highest surfac dip content found winter distribut northwestern bay surfac organ pollut show estuari pollut area past year din dip eutroph shown invert u shape trend bay chang n limit p limit econom develop phytoplankton absorpt bottom miner releas factor influenc content distribut nutrient bay

D061006;D014874

T131;T083

36,307,944

trace element edibl tissu elasmobranch north aegean sea eastern mediterranean potenti risk consumpt trace element potenti bioaccumul marin organ biomagnifi toward upper level marin trophic web result rang negat effect organ elasmobranch high suscept bioaccumul trace metal consumpt human increas worldwid therefor import monitor trace metal content edibl tissu elasmobranch work reveal content trace metal edibl tissu elasmobranch speci caught greek water level permiss limit hg pb found speci analysi lifetim consumpt risk adult children use target hazard quotient thq reveal high risk two toxic substanc prioriti list substanc name hg preliminari result research requir understand better issu

D014131;D019216;D008628;D018940;D014874

T123;T121;T131;T196;T013

36,307,943

measur person damag larg scale disast review report publish japanes fire disast manag agenc great east japan earthquak tsunami studi aim identifi challeng estim person damag earli stage disast

D055866;D004190;D005390

T070;T067

36,307,942

burden communic diseas lebanon trend past decad present studi aim review main communic diseas experienc upsurg past decad lebanon highlight reason behind increas data report communic diseas till obtain lebanes ministri public health lmoph epidemiolog surveil databas tuberculosi measl mump leishmaniasi hepat main communic diseas show sharp increas past measl outbreak occur leishmaniasi outbreak mump hepat outbreak highest percentag report diseas beqaa north governor massiv influx syrian refuge lebanon togeth poor water manag system poor sanit depriv live condit limit health care access rural area might contribut upsurg communic diseas although lmoph succeed contain outbreak effort need improv identifi gap avoid futur outbreak

D009107;D006506;D003141;D012036;D008457;D007896

T047;T098

36,307,925

outcom acut myocardi infarct patient preexist physic disabl report unit state signific proport world popul live physic disabl pd requir healthcar servic risk factor cardiovascular diseas cvd hypertens diabet preval among patient pd studi compar outcom follow acut myocardi infarct ami patient preexist pd without use nation inpati sampl nis

D009203;D062645

T061;T047

36,307,914

rapid lipid laden plaqu identif intravascular optic coher tomographi imag base time seri deep learn significancecoronari heart diseas highest rate death morbid western world atherosclerosi asymptomat condit consid primari caus cardiovascular diseas accumul low densiti lipoprotein trigger inflammatori process focal area arteri lead format plaqu lipid laden plaqu contain necrot core may eventu ruptur caus heart attack stroke late intravascular optic coher tomographi iv oct imag use plaqu assess interpret iv oct imag perform visual burdensom requir high train physician accur plaqu identificationaimour studi aim provid high throughput lipid laden plaqu identif assist vivo imag offer faster screen guid decis make percutan coronari interventionsapproachan line wise classif methodolog base time seri deep learn present fulfil aim classifi train valid databas consist iv oct imag arteri section train physician expertis analysi iv oct imag provid visual evalu databas use ground truth train validationresultsthi method show accuraci sensit specif respect deep learn methodolog potenti increas speed lipid laden plaqu identif provid high throughput b scanssconclusionsthes encourag result suggest method allow high throughput video rate atherosclerot plaqu assess autom tissu character vivo imag provid faster screen assist guid decis make percutan coronari intervent

D058226;D003324;D000077321

T020;T066;T047;T046;T031

36,307,894

automat quantit measur left atrial pressur use mitral regurgit spectrum clinic studi comparison float cathet explor measur lap eq accur quantit left atrial pressur lap measur calcul equat method use mitral regurgit spectrum

D008944

T047

36,307,893

neuroprotect effect donepezil induc neurotox purpos studi investig neuroprotect effect donepezil amyloid induc neurotox possibl mechan

D018696

T121;T169

36,307,892

nationwid random control trial addit treatment isol local pancreat cancer recurr use stereotact bodi radiat therapi arcad diseas recurr main caus mortal resect pancreat ductal adenocarcinoma pdac resect patient isol local pdac recurr occur retrospect studi suggest stereotact bodi radiat therapi sbrt might lead improv local control patient potenti benefici effect surviv qualiti life nationwid random control trial addit treatment isol local pancreat cancer recurr use stereotact bodi radiat therapi arcad investig valu sbrt addit standard care patient isol local pdac recurr compar standard care alon regard surviv qualiti life outcom

D016634;D010190;D021441

T061;T191

36,307,891

effect support group leader educ program joint develop health profession patient peer leader self efficaci among leader scleroderma support group two arm parallel partial nest randomis control trial peopl rare diseas like receiv diseas educ emot practic support peer led support group way rare diseas support group deliv outsid health care system untrain leader potenti benefit may achiev harm dissemin inaccur inform may occur primari object evalu effect rare diseas support group leader educ program develop collabor research peer support group leader patient organ leader compar waitlist control peer leader self efficaci among scleroderma support group leader

D020377;D012594

T047;T041

36,307,889

deer antler extract promot tibia fractur heal mice activ bmp smad signal pathway deer antler tradit chines medicin function tonifi kidney strengthen bone often use treat orthoped diseas

D000999;D013978;D003670

T023;T015;T037

36,307,888

dual probe fluoresc spectroscopi sensit quantit alzheim amyloid patholog protein misfold promin patholog hallmark neurodegen disord includ alzheim diseas ad studi shown divers sheet rich protein deposit amyloid plaqu neurofibrillari tangl present across differ brain region might underli differ diseas phenotyp certain type aggreg might associ cognit declin conform sensit fluoresc amyloid probe abil report differ structur protein aggreg virtu shift emiss spectra defin bind affin fluoresc amyloid probe bsb mcaad diseas relev protein aggreg combin two probe examin formalin fix paraffin embed mous human brain sampl coupl quantit spectral phasor analysi dual probe stain approach reveal remark heterogen protein aggreg across sampl distinct emiss spectra consist certain type deposit present mous human brain section sensit stain imag analysi approach outperform convent immunohistochemistri detect spectral differ greater parenchyma cognit normal ad case indic subtl yet widespread proteopathi associ diseas method offer sensit object quantit examin protein misfold patholog use convent tissu section

D000544;D000686

T047;T048

36,307,887

predict risk sepsi comparison machin learn method case studi virginia hospit sepsi inflamm caus bodi system respons infect infect could result mani diseas pneumonia urinari tract infect ill symptom fever tachycardia tachypnea etc unfortun sepsi remain critic problem hospit lead mani issu increas mortal rate health care cost health care util earli detect sepsi patient help respond quick take prevent action prevent major issu main aim studi predict risk sepsi util patient demograph clinic inform ie patient gender age sever level mortal risk admit type along hospit length stay six machin learn approach logist regress lr nave bay support vector machin svm boost tree classif regress tree cart bootstrap forest use predict risk sepsi result show differ machin learn method perform term various measur instanc bootstrap forest machin learn method exhibit highest perform auc r squar svm boost tree show highest perform term misclassif rate bootstrap forest consid best machin learn method predict sepsi regard appli featur research main show superior perform effici two perform measur auc r squar

D000069550;D018805

T047;T046;T066

36,307,886

influenc factor biliari fistula radic resect hilar cholangiocarcinoma prospect cohort biliari fistula common serious complic radic resect hilar cholangiocarcinoma aim evalu influenc factor biliari fistula radic resect provid insight clinic treatment hilar cholangiocarcinoma

D018285;D018281;D001650;D002761

T047;T191

36,307,879

lpcat act independ prognost biomark correl immun infiltr hepatocellular carcinoma lysophosphatidylcholin acyltransferas lpcat overexpress multipl human tumor howev role lpcat hepatocellular carcinoma hcc understood aim explor relationship lpcat express prognosi clinicopatholog featur tumor microenviron tme immun cell infiltr immun checkpoint gene express relat signal pathway hcc furthermor also explor relationship lpcat express drug sensit hcc treatment

D006528;D008113

T191

36,307,878

lung chest wall volum vital capac manoeuvr osteogenesi imperfecta although osteogenesi imperfecta oi affect connect tissu pulmonari function might compromis thorac deform oi known restrict lung diseas spirometri provid global measur without local site restrict opto electron plethysmographi oep non invas method abl underlin alter respiratori function well ventilatori thoraco abdomin paradox spontan breath aim reconstruct thoraco abdomin surfac perform local analys trunk motion make quantit comparison trunk shape respiratori kinemat accord oi sever particular maxim inspiratori expiratori expans cross section studi studi thoraco abdomin compartment analysi adult oi patient type iii rest vital capac manoeuvr use oep also appli new method creat realist accur model perform local analys trunk motion make quantit comparison trunk shape respiratori kinemat

D035441;D010013

T023;T047

36,307,877

cystic echinococcosi northern tanzania pilot studi maasai livestock keep communiti close similar life cycl echinococcus granulosus sensu lato e granulosus sl caus cystic echinococcosi ce human taenia multicepscoenurus cerebrali caus cerebr coenurosi small rumin recent evid highlight livestock maasai communiti northern tanzania suffer increas preval cerebr coenurosi lead concern possibl concurr increas risk human ce aim studi estim preval human abdomin ce preval speciesgenotyp e granulosus sl livestock maasai communiti

D020019;D004443;D048209;D003560

T047;T190;T204

36,307,876

estrous cycl matter neurosci ovarian hormon fluctuat rodent estrous cycl human menstrual cycl known signific impact brain physiolog diseas risk yet variabl larg ignor preclin neurosci research clinic studi psychiatr practic

D030762;D012727

T032;T040

36,307,874

stimul tibial nerv repetit improv incontin parkinson electron stripe trial randomis control trial tibial nerv stimul bladder symptom parkinson diseas use self contain wearabl devic bladder symptom common parkinson diseas pd affect half individu signific impact qualiti life well implic morbid contribut fall hospit admiss treatment bladder symptom complic tendenc side effect peopl pd includ cognit impair gait instabl anti muscarin develop new better treatment therefor warrant tibial nerv stimul form neuromodul demonstr improv overact bladder symptom non neurogen cohort previous requir hospit attend aim explor use intervent use simpl devic use patient home

D053201;D010300;D004561;D014549;D000076251

T061;T047;T046;T073

36,307,873

implant collam len implant icl versus small incis lenticul extract smile low moder myopia studi protocol random non inferior trial implant collam len implant icl form foldabl posterior chamber phakic intraocular len refract surgeri general impair cornea natur accommod potenti advantag icl keratorefract laser procedur includ less induct higher order aberr hoa enhanc retin imag magnif hand small incis lenticul extract smile current one popular refract surgeri procedur also offer excel visual outcom particular eye low moder amount myopia aim studi evalu whether iclticl toric icl compar smile low moder myopia term refract outcom month post oper

D009216;D007910

T047;T074

36,307,871

osteoblast osteoclast import switch tumour cell dormanc bone metastasi bone metastasi occur tumour cell dissoci primari tumour enter circul circul tumour cell ctcs colon site bone dissemin tumour cell dtcs bone marrow seem particular dormanc induc environ dtcs yet mechan dormanc initi reactiv interact within bone marrow elucid intrigu evid suggest dormanc revers state switch depend presenc various bone marrow resid cell particular osteoclast osteoblast becom clear two cell contribut regul dormant tumour cell bone direct interact indirect secret factor involv mechan includ tgf signal wnt signal axi notch pathway etc detail review specif focus ascertain dynam interact tumour cell dormanc bone remodel addit highlight role inflammatori cytokin cell cell communic also discuss potenti clinic relev remodel bone marrow nich control dormant tumour cell understand uniqu role osteoclast osteoblast regul tumour dormanc bone marrow provid new insight prevent treat tumour bone metastasi

D001859;D009360

T191;T025

36,307,869

myocardi infarct size independ predictor intramyocardi haemorrhag acut reperfus myocardi ischaem rat previous studi haemorrhag occur larg infarct size studi found moder correl extent necrosi haemorrhag extent infarct size studi limit studi aim find correl intramyocardi haemorrhag imh myocardi infarct mi myocardi oedema small larg size mi mr scanner

D003287;D009203

T047;T130

36,307,868

reemerg pathogen autoantibodi produc b cell clone myasthenia gravi follow b cell deplet therapi myasthenia gravi mg autoantibodi mediat autoimmun disord neuromuscular junction small subset patient mg autoantibodi target muscl specif tyrosin kinas musk musk mg patient respond well cd mediat b cell deplet therapi bcdt achiev complet stabl remiss howev relaps often occur understand immunomechan under relaps studi autoantibodi produc b cell cours bcdt develop fluoresc label antigen enrich musk specif b cell valid novel nalm cell line engin express human musk specif b cell receptor b cell million differ sampl collect nine musk mg patient screen musk specif success isol two musk specif igg subclass express plasmablast two patient experienc relaps bcdt induc remiss human recombin musk mab generat valid bind specif character molecular properti mab strong musk binder recogn ig like domain musk show pathogen capac test acetylcholin receptor achr cluster assay presenc persist clonal relat musk specif b cell clone investig b cell receptor repertoir trace uniqu clone deriv longitudin sampl collect two patient clonal variant detect multipl timepoint span five year reemerg bcdt mediat remiss predat diseas relaps sever month find demonstr reservoir rare pathogen musk autoantibodi express b cell clone surviv bcdt reemerg circul prior manifest clinic relaps overal studi provid mechanist understand musk mg relaps valuabl candid biomark relaps predict

D020794;D009157

T047;T126;T116;T192

36,307,867

long noncod rna irf associ pest des petit rumin infect pest des petit rumin ppr acut high contagi diseas long signific threat small rumin product worldwid howev molecular mechan under host pprv interact remain unclear long noncod rnas lncrnas regul ppr virus pprv infect rare report far first demonstr pprv infect induc obvious innat immun respons caprin endometri epitheli cell eec h post infect hpi moi subsequ determin pprv infect associ signific differenti express sde lncrnas name upregul downregul lncrnas caprin eec compar mock control cell hpi use deep sequenc technolog import bioinformat preliminarili analys reveal de lncrnas close relat immun respons furthermor identifi system lncrnas relat immun respons focus role lncrna irf regul innat immun respons interest found irf potent posit regul ifn isg product signific inhibit pprv replic host cell addit data reveal irf posit correl potenti target gene irf enhanc activ irf express isg interact irf studi suggest irf could new host factor target develop antivir therapi pprv infect

D029021;D062085;D018107;D015511

T123;T047;T005;T114

36,307,864

raba gtpase regul epitheli mesenchym transit modul rac activ epitheli mesenchym transit emt critic underpin process cancer progress recurr resist drug treatment identif new regul emt could lead develop effect therapi improv outcom advanc cancer current studi discov use varieti vitro vivo approach raba function essenti emt relat manifest stem invas properti consist raba suppress abolish cancer cell self renew tumor form abil term downstream signal found raba regul emt achiev control activ rac gtpase introduc activ rac effici rescu emt gene express invas tumor format suppress raba knockdown vitro vivo cancer model summari studi identifi raba rac signal axi key regulatori mechan process emt cancer progress suggest potenti therapeut approach control process

D020830;D001943

T191;T126;T116

36,307,863

differenti tracheobronchi involv granulomatosi polyangi relaps polychondr chest ct cohort studi patient tracheobronchi involv differenti diagnosi granulomatosi polyangi gpa relaps polychondr rp challeng aim studi describ characterist airway abnorm chest comput tomographi ct patient gpa rp determin whether specif imag criteria could use differenti

D011081;D014890

T047

36,307,862

multicent random control trial compar effect starc sud skill train affect regul cultur sensit approach versus treatment usual trauma expos refuge substanc use problem refuge often report high level psycholog distress due traumat experi flight well mani post migrat stressor refuge hazard substanc use exist substanc use disord sud particular vulner group prevent therapeut measur avail aim studi investig effect integr cultur sensit group therapi approach starc sud improv affect regul refuge substanc relat problem

D012036;D013313;D019966;D016739

T033;T098;T048

36,307,861

season fluctuat babesia bigemina rhipicephalus microplus brangus nellor cattl rear cerrado biom brazil tick rhipicephalus microplus ixodida ixodida canestrini caus substanti econom health loss cattl product main vector babesia bigemina piroplasmida babesida smith kilborn babesia bigemina respons tick born diseas known babesiosi caus hemolyt anemia fever death studi report investig relationship number tick per anim number b bigemina cytochrom b gene cbisg copi blood brangus nellor cattl rear without acaricid treatment brazilian cerrado biom year period

D001403;D048494;D001404;D002418

T047;T204

36,307,860

evalu cross platform compat dna methyl base glucocorticoid respons biomark identifi blood base dna methyl pattern minim invas way detect biomark predict age characterist certain diseas condit well respons immunotherapi microarray platform continu evolv increas scope cpgs measur new discoveri base recent platform version compar avail data previous version platform unknown neutrophil dexamethason methyl index ndmi blood base dna methyl biomark built illumina methylationep k array measur epigenet respons dexamethason dex synthet glucocorticoid often administ inflamm compar ndmi one built use data illumina methyl k ndmi

D019175;D005938

T125;T039;T044;T109

36,307,859

applic exom sequenc prenat diagnosi fetal structur anomali clinic experi lesson learn cohort fetus exom sequenc es becom wide avail prenat diagnosi howev data clinic util integr clinic manag remain limit practic herein report experi implement prenat es pes larg cohort fetus anomali detect ultrasonographi use hospit base hous multidisciplinari team mdt facilit three step genotyp driven follow phenotyp driven analysi framework

D059472;D016216

T060;T028

36,307,858

high definit transcrani direct current stimul hd tdcs augment therapi late life depress lld suboptim respons treatment studi protocol doubl blind random sham control trial late life depress lld poorer prognosi higher relaps rate younger adult one third patient lld show suboptim respons antidepress therapi lld associ signific impair cognit daili function studi evalu therapeut effect high definit transcrani direct current stimul hd tdcs depress cognit symptom lld current random control trial assess efficaci hd tdcs augment therapi antidepress compar sham control subject lld

D065908

T061

36,307,857

social accept livestock administ endectocid malaria control vhemb district limpopo provinc south africa malaria continu lead caus morbid mortal africa convent malaria control strategi indoor residu spray insecticid treat bed net limit effect malari vector consequ develop altern supplementari strategi requir one potenti strategi use livestock administ endectocid control vector mosquito feed outdoor livestock howev sinc strategi requir support local communiti livestock owner consent anim treat implement agre affect communiti aim studi assess social accept use livestock administ endectocid malaria endem villag vhemb district limpopo provinc south africa malaria incid high

D008288;D000852;D007306

T131;T047;T204

36,307,855

new insight role lipid metabol relat protein rheumat heart valv diseas aim studi determin express lipid metabol relat protein rheumat heart valv diseas rhvd

D012214;D006349

T047

36,307,853

impact age cerebrospin fluid space high convex medial subarachnoid space decreas age impair cerebrospin fluid csf dynam may contribut pathophysiolog neurodegen diseas play crucial role brain health older peopl nonetheless age relat chang well elucid disproportion enlarg subarachnoid space hydrocephalus desh neuroimag phenotyp idiopath normal pressur hydrocephalus origin impair csf dynam close associ age studi aim investig pathophysiolog desh determin age relat chang csf dynam

D006850

T047

36,307,852

molecular surveil anti malari drug resist genet divers plasmodium falciparum chloroquin sulfadoxin pyrimethamin withdraw quibdo colombia resist anti malari drug associ polymorph target gene surveil molecular marker import detect emerg mutat associ drug resist signal recov sensit anti malari previous use

D000962;D016778

T121;T047

36,307,851

preconcept fear childbirth experi need women fear childbirth first pregnanc although earli case studi indic fear childbirth predat woman first pregnanc concept preconcept fear childbirth larg unexplor studi report preval preconcept fear childbirth found higher level preval estim pregnant popul howev littl known women fear childbirth becom pregnant aim qualit studi give voic experi often neglect group women

D036801;D036861

T061;T040

36,307,850

polici stewardship landscap nation health research system look like develop countri like iran qualit studi health research system hrs import nation prioriti requir systemat function approach evalu hrs iran develop countri identifi challeng reveal stewardship relat role whole system oper well studi aim assess hrs term stewardship function highlight enhanc point

D003906;D006078

T064;T080

36,307,849

intent chang polici awar health knowledg relat chang dietari intak follow sugar sweeten beverag tax south africa studi april south africa implement health promot levi hpl one first sugar sweeten beverag ssb tax base gram sugar beyond gml object studi examin whether psycholog construct tax awar ssb knowledg ssb risk percept intent reduc ssb intak associ tax beverag intak whether chang pre post tax whether modifi effect hpl

D000080845

T168

36,307,845

safeti studi intraop radiat therapi follow stereotact bodi radiat therapi multi agent chemotherapi treatment local pancreat adenocarcinoma studi protocol phase trial local pancreat adenocarcinoma carri poor prognosi even aggress therapi patient may develop locoregion diseas first site failur may role intensif local therapi radiat therapi radiat dose escal pancreat cancer limit proxim tumor duodenum howev duodenum remov whippl procedur allow opportun dose escal intraop radiat therapi iort although prior studi shown potenti benefit iort pancreat cancer studi util ablat dose biolog effect dose bed gy furthermor optim radiat target volum set unclear increas interest triangl volum tv border celiac axi superior mesenter arteri common hepat arteri portal vein superior mesenter vein dissect area advoc surgeon heidelberg contain extra pancreat perineur lymphat tract may harbor microscop diseas risk mediat local failur interest recent analysi institut indic near local failur occur tv therefor purpos protocol evalu safeti deliv ablat radiat dose tv iort follow neoadjuv chemotherapi stereotact bodi radiat therapi sbrt

D010190;D000230;D016634

T061;T191

36,307,844

famili build mean qualit explor new definit uk base studi import improv men women knowledg sexual reproduct health emphasis numer global health polici fertil awar literatur highlight disproportion higher number articl relat pregnanc prevent compar pregnanc plan justifi mani context howev recent concert effort improv fertil awar warrant closer investig basic reproduct health terminolog object studi explor particip view famili build provid definit

D005193;D005298

T071;T032;T055;T040;T033;T062;T058

36,307,843

studi knowledg attitud practic regard patient educ hypertens among communiti pharmacist china prevent treatment hypertens patient educ import measur improv awar rate control rate patient profession geograph advantag communiti pharmacist enabl play import role patient educ hypertens purpos studi understand situat patient educ hypertens conduct chines communiti pharmaci put forward measur accord problem

D006973;D003157

T047;T058

36,307,841

mical substrat ubiquitinas trim regul tumorigenesi colorect cancer molecul interact casl like protein mical believ regul cytoskeleton dynam tight junction format neurit outgrowth howev biolog role under mechan colorect cancer crc remain larg elus

D015972;D015179

T045;T191

36,307,840

vitamin b defici may play etiolog role atroph glossiti grade clinic case control studi exist studi report signific associ atroph glossiti ag hematin defici includ iron folat vitamin b defici howev find inconsist ag grade partial complet atrophi still unclear whether hematin defici associ grade ag

D005928;D006397;D020138;D014806;D000740

T121;T047

36,307,839

healthcar system learn look tension innov process systemat literatur review scholarship innov process healthcar system lack depth appreci tension tension often revolv around barrier result individu assess priorit guid action eventu overcom barrier order develop differenti understand tension role healthcar innov process paper aim shed light multifacet way tension emerg dealt hinder time facilit innov process

D003695;D006076

T092;T058;T093

36,307,837

short term efficaci advers effect collagenas clostridium histolyticum inject percutan needl fasciotomi limit fasciectomi treatment dupuytren contractur network meta analysi random control trial dupuytren contractur dc chronic debilit fibroprolif disord common treatment option includ collagenas clostridium histolyticum inject ci percutan needl fasciotomi nf limit fasciectomi lf superior one specif treatment remain controversi studi aim assess short term efficaci safeti ci nf lf treatment dc

D004387;D004204

T047;T037

36,307,836

maintain activ ankylos spondyl patient treat tnfi andor nsaid least week cross section studi brazil aim studi evalu diseas activ among patient axial spondyloarthr treat tumor necrosi factor inhibitor tnfi andor nonsteroid anti inflammatori drug nsaid least week privat outpati set brazil

D013167

T047

36,307,835

tubulovil adenoma high grade dysplasia vulva harbor high tumor mutat burden cancer associ mutat case report vulvar cancer rare diseas account approxim gynecolog malign primari adenocarcinoma intestin type vulva precancer lesion extrem rare detail regard origin evolut relat genet mutat unknown treatment option cancer defin

D000236;D014846;D000230;D007414;D011230

T191

36,307,834

risk factor air leakag invas mechan ventil pediatr intens care unit studi aim investig air leakag invas mechan ventil imv pediatr intens care unit picu explor potenti risk factor

D012128;D012131

T047;T046

36,307,833

plasmodium falciparum communiti preval health seek behaviour rural sussundenga district mozambiqu impact nation direct malaria control intervent hing understand malaria transmiss prevent communiti level decis seek care health seek behaviour provid valuabl insight knowledg malaria access care efficaci malaria case manag thus far studi focus central mozambiqu aim describ communiti level plasmodium falciparum preval health seek behaviour among resid sussundenga mozambiqu rural villag manica provinc high malaria incid report sussundenga sede health centr rhc

D000962;D016778;D008288

T121;T047

36,307,832

transcriptom analysi sputum cell reveal two distinct molecular phenotyp asthma chronic obstruct pulmonari diseas overlap elder littl known pathogenesi asthma chronic obstruct pulmonari diseas copd overlap aco studi examin molecular phenotyp aco elder

D029424;D001249

T047

36,307,831

introduct modifi degan classif specifi treatment algorithm fractur anterior process calcaneus fractur anterior process calcaneus often miss treatment result receiv littl attent current literatur aim studi specifi treatment algorithm modif degan classif

D002111;D050723

T023;T037

36,307,830

improv pediatr covid vaccin uptak use mhealth tool moveup studi protocol random control trial coronavirus diseas covid vaccin demonstr excel effect infect sever diseas death howev pediatr covid vaccin rate lag among individu rural medic underserv communiti research object current protocol determin effect vaccin communic mobil health mhealth applic app parent decis vaccin children covid

D000086382;D017216;D014612

T129;T121;T116;T067;T047;T058

36,307,828

sctam seq enabl target high confid analysi dna methyl singl cell singl cell dna methyl profil current suffer excess nois andor limit cellular throughput develop sctam seq target bisulfit free method profil cpgs cell per experi dropout rate low demonstr sctam seq resolv dna methyl dynam across b cell differenti blood bone marrow identifi intermedi differenti state previous mask sctam seq addit queri surfac protein express thus enabl integr singl cell dna methyl inform cell atlas data summari sctam seq high throughput high confid method analyz dna methyl singl cpg resolut across thousand singl cell

D019175;D059014

T063;T059;T044

36,307,827

proxim fibular osteotomi versus high tibial osteotomi treat knee osteoarthr systemat review meta analysi knee osteoarthr koa varus align medial space stenosi common degen disord elder realloc forc bear medial later compart anti varus osteotomi includ high tibial osteotomi hto proxim fibular osteotomi pfo correct mechan line lower extrem use surgic method allevi abras medial cartilag reliev pain pfo base non uniform settlement theori cut small section proxim fibula ie fibula head break fibula weaken support later tibial plateau last reduc gap later side knee joint offset knee varus deform caus weight bear conduct systemat review meta analysi compar clinic outcom pfo versus hto intervent

D020370

T047

36,307,826

toler eribulin correl polymorph neuropathi unselect popul femal patient metastat breast cancer result multicent singl arm phase iv painter studi metastat breast cancer mbc incur diseas treatment focus prolong patient pts overal surviv os improv qualiti life eribulin microtubul inhibitor increas os pre treat mbc pts common advers event ae asthenia neutropenia peripher neuropathi pn

D001943;D010523;D009503

T047;T191

36,307,825

transcriptom metabolom analys provid insight influenc polylysin synthetas metabol streptomyc albulus poli l lysin pl main secondari metabolit streptomyc albulus wide use food industri polylysin synthetas pls last enzym pl biosynthet pathway previous studi reveal pls overexpress albulus cicc result effici product pl studi pls gene knockout strain initi construct genom transcriptom metabolom approach integr studi effect high express knockout pls gene express metabolit synthesi albulus high express pls result signific differenti express gene deg known differenti metabolit wherea inactiv pls result signific deg known differenti metabolit express gene negat posit associ pls express respect subsequ influenc mechan high express inactiv pls pl biosynthet pathway elucid twelv metabolit decreas yield high express strain pls increas product pls knockout strain identifi result demonstr influenc pls metabol albulus present work provid theoret basi improv product capac pl mean metabol engin develop bioactiv substanc deriv albulus

D011107;D013302

T007;T116

36,307,824

type lymphomatoid papulosi pityriasi lichenoid et varioliformi acuta like featur child parvovirus infect controversi diagnosi spectrum lymphoid prolifer case report literatur review lymphomatoid papulosi lyp rare condit pediatr lyp histolog type report children differenti diagnosi lyp spectrum lymphoid prolifer remain controversi

D000086382;D017731;D010322;D017514

T047;T191;T067

36,307,822

chang cross section area vastus mediali obliqu patient recurr patellar disloc treat tibial tubercl transfer combin medial patellofemor ligament reconstruct axial ct investig chang cross section area csa vastus mediali obliqu vmo patient recurr patellar disloc rpd treat tibial tubercl transfer combin medial patellofemor ligament mpfl reconstruct imag method guid clinic treatment rehabilit

D031222;D057071;D004204;D007593

T033;T037;T030

36,307,821

anca associ vascul cardiac valv veget two teenag male two case report literatur review anti neutrophil cytoplasm antibodi anca associ vascul term use describ system vasculitid affect small medium size blood vessel granulomatosi polyangi gpa type anca associ vascul aav rare children estim preval per million even rare manifest cardiac abnorm secondari anca associ vascul pediatr popul

D056648;D014890

T047

36,307,820

methodolog protocol conduct scope review health research onbywith indigen women north america indigen women north america experi multipl inequ term health well compar non indigen women indigen men effort understand health dispar surg research field indigen women health well last year object studi conduct scope review current research field determin theoret framework use studi topic indigen women health well north america

D003695;D044382

T058;T098;T093

36,307,819

distribut lipid level preval hyperlipidemia data nhane lipid lower therapi import distribut lipid level incid hyperlipidemia may vari differ subgroup popul aim explor distribut lipid level preval hyperlipidemia subpopul subgroup factor includ age sex race smoke status

D006949;D015228

T033;T047

36,307,818

neonat ankyloglossia interfer growth infant first month life case seri nest cohort studi ankyloglossia common report one major caus breastfeed difficulti lack research infant growth latch perform clinic measur

D000072676

T019

36,307,817

use nomin group techniqu identifi barrier facilit prevent hiv use combin day pre exposur prophylaxi medic opioid use disord prevent hiv transmiss among peopl inject drug pwid key element us end hiv epidem strategi includ pre exposur prophylaxi prep medic opioid use disord moud lead decreas hiv transmiss moud social health benefit meanwhil prep addit hiv prevent advantag sexual risk inject stimul howev medic often prescrib differ set requir multipl visit initi strategi integr servic ie co prescript offer day prescript may reduc demand patient could benefit

D065129;D019380;D015819;D015658;D009293

T061;T121;T047;T048

36,307,816

global inequ covid vaccin coverag among health care worker health care worker hcws forefront covid respons high risk infect result prioriti group covid vaccin paper present global pattern covid vaccin coverag among hcws hcws priorit identifi factor associ earli vaccin coverag

D000073887;D000086382

T058;T067;T047

36,307,815

effect medial calcar support proxim humer fractur treat lock plate studi report mix result import medial calcar support treatment proxim humer fractur purpos studi compar radiograph function outcom patient displac proxim humer fractur vari level medial support

D012784;D006810

T037

36,307,814

identif novel fulli human anti toxic shock syndrom toxin tsst singl chain variabl fragment antibodi avert tsst induc mitogenesi cytokin secret staphylococc superantigen virul factor help pathogen escap immun system develop infect toxic shock syndrom toxin tsst one studi superantigen whose role toxic shock syndrom particular disord demonstr inhibit tsst product antibiot target tsst monoclon antibodi might one best strategi prevent tsst induc cytokin storm follow lethal

D057127

T129

36,307,812

improv periop manag surgic set trauma surgeri approach periop manag surgic instrument implant compris set trauma surgeri identifi complex resourc intens activ due non standard inventori redund surgic instrument unnecessari steril cycl intellig trauma care program aim improv periop manag therebi reduc environment impact util standard inventori steril implant portfolio barcod enabl digit safeti certif digit restock servic

D013242;D013525

T058;T074

36,307,811

explor barrier facilit integr polici formul implement famili plan urban develop programm nigeria peopl live urban area rural communiti nigeria urban develop ud requir urgent polici programmat attent although popul factor identifi import achiev nation develop goal evid suggest meet famili plan fp reproduct health rh need vulner urban popul serv import recip achiev popul growth rate consist build sustain habit prosper urban set fp remain neglect subject ud initi nigeria studi explor barrier facilit achiev integr polici formul implement fp ud programm nigeria

D005193;D014506

T033;T068;T058

36,307,810

compar analysi prognosi extern beam radiat therapi ebrt ebrt plus brachytherapi glioblastoma multiform seer popul base studi radiotherapi one effect way treat glioblastoma multiform gbm aim explor prognost differ extern beam radiotherapi ebrt ebrt combin brachytherapi ebrt bt

D001918;D005909

T061;T191

36,307,809

psychometr evid percept scale covid vaccin process peruvian dentist preliminari valid current pandem context dental profession greater occup risk due healthcar activ place expect vaccin mean protect time hope immun process safe reliabl comfort give greater peac mind return work therefor aim present studi develop provid preliminari valid scale measur percept covid vaccin process peruvian dental profession

D000086663;D000086382

T200;T047;T067

36,307,808

antioxid brain tumor current therapeut signific futur prospect brain cancer regard among deadliest form cancer worldwid distinct tumor microenviron inher characterist brain tumor cell virtual render resist major convent advanc therapi oxid stress os key disruptor normal brain homeostasi involv carcinogenesi differ form brain cancer thus antioxid may inhibit tumorigenesi prevent os induc various oncogen factor antioxid hypothes inhibit cancer initi endors dna repair suppress cancer progress creat energi crisi preneoplast cell result antiprolif effect effect refer chemoprevent effect mediat antioxid mechan addit antioxid minim chemotherapi induc nonspecif organ toxic prolong surviv antioxid also support prooxid chemistri demonstr chemotherapeut potenti particular high pharmacolog dose trigger os promot free radic product essenti activ cell death pathway grow bodi evid also reveal role exogen antioxid adjuv abil revers chemoresist review explain influenc differ exogen endogen antioxid brain cancer refer chemoprevent chemotherapeut role role antioxid metabol reprogram influenc downstream signal event induc tumor suppressor gene mutat critic discuss final review hypothes pro antioxid role involv anticanc mechan antioxid molecul kill neoplast cell inhibit tumor recurr follow convent cancer treatment requir pro antioxid effect exogen antioxid brain tumor treatment differ condit critic discuss along reason behind conflict outcom differ report final also mention influenc factor regul pharmacolog exogen antioxid brain cancer treatment conclus achiev consist clinic outcom antioxid treatment brain cancer rigor mechanist studi requir respect type form stage brain tumor concomit treatment regimen also need adequ consider

D000975;D001932

T123;T121;T191;T039;T044

36,307,807

facil process adip acid product high yield oxid hexanediol use rest cell gluconobact oxydan adip acid aa one import industri chemic use main product nylon also make polyurethan plastic unsatur polyest resin recent compon biodegrad polyest poli butylen adip terephthal pbat main rout aa product util benzen feedstock generat copious amount greenhous gas henc altern clean product rout aa renew bio base feedstock draw increas attent earlier report potenti gluconobact oxydan cell oxid hexanediol potenti biobas diol aa

D020600;D000074382

T197;T007

36,307,806

food insecur eat habit lebanes children age year covid pandem socioeconom crisi nation studi food insecur lack access nutriti healthi food due econom financi insuffici food insecur expect higher difficult time lebanon face mani financi polit econom health debat present studi aim find preval food insecur among lebanes children covid pandem correl

D000086382

T047;T067

36,307,805

erythropoietin plga peg local treatment promot function recoveri neurovascular regener peripher nerv injuri traumat peripher nerv injuri tpni major medic problem univers accept pharmacolog treatment hypothes encapsul pro angiogen erythropoietin epo amphiphil plga peg block copolym could serv local control releas drug deliveri system enhanc neurovascular regener nerv injuri

D059348;D020426;D004921;D000071576

T121;T116;T037;T125;T047

36,307,804

polygen associ glomerular filtrat rate declin world trade center respond factor associ estim glomerular filtrat rate egfr declin low risk adult remain relat unknown hypothes polygen risk score prs associ egfr declin

D051436;D003920

T047

36,307,803

associ metabol factor radiograph knee osteoarthr earli diseas cross section studi individu knee pain metabol factor shown associ sever radiograph knee osteoarthr rkoa howev knowledg need earli clinic knee osteoarthr koa aim studi associ metabol factor radiograph knee osteoarthr oa individu knee pain second aim studi associ metabol factor rkoa normal bmi overweightobes respect

D020370;D024821

T047

36,307,802

spectral domain optic coher tomographi characterist cystic retin tuft investig characterist cystic retin tuft crts widefield spectral domain optic coher tomographi

D041623;D012167

T060;T047

36,307,801

similar cardiometabol risk factor among random male femal pair larg observ studi japan previous observ studi shown similar cardiometabol risk factor spous still possibl result reflect age similar spous rather environment factor spous eg cohabit effect clarifi import mate cardiometabol risk factor similar environment factor necessari examin whether observ random male femal pair maintain age spousal pair studi aim determin whether similar found spousal pair cardiometabol risk also observ random male femal pair

D003924;D006973;D002318

T047

36,307,800

transpos element expans low level pirna silenc grasshopp may caus genom gigant transpos element tes liken parasit genom reproduc move ceaseless host continu enlarg host genom howev piwi interact rna pirna pathway defend anim genom harm consequ te invas impos small rna mediat silenc compar te activ two grasshopp speci differ genom size acridida locusta migratoria manilensisc pg angaracri rhodopac pg ascertain influenc pirna

D006110;D005877

T047;T204

36,307,799

causal associ circul amino acid blood pressur mendelian random studi circul level amino acid associ blood pressur bp observ studi howev causat associ hypothes difficult prove human studi aim use two sampl mendelian random analys evalu potenti causal associ circul level amino acid bp risk hypertens

D057182;D006973

T062;T047

36,307,798

enabl mental health task share collect case studi undergradu clinic associ train programm south africa shortag human resourc need deliv mental health servic like exacerb covid due mental health workforc shortag task shift task share approach implement number countri clinic associ mid level cadr work supervis medic practition could play role deliv mental health servic clear adequ prepar studi explor mental health curriculum content undergradu clinic associ train programm south africa view key inform adequaci train mental health

D008603;D000086382

T047;T067;T041

36,307,797

lipid product lignocellulos biomass use engin yarrowia lipolytica strain util industri wast feedstock microbi base process one high potenti approach develop sustain environment benefici valuabl bioproduct inter alia lipid rye straw hydrolys possibl renew carbon sourc bioconvers contain larg amount xylos inaccess wild type yarrowia lipolytica strain although oleagin yeast possess crucial gene xylos util necessari induc metabol pathway effici growth xylos mix sugar agricultur wast either way biotechnolog product singl cell oil sco lignocellulos hydrolys requir yeast genom modif adapt suboptim environ

D025062

T004

36,307,796

develop valid famili function measur aborigin torr strait island adult famili kinship network key aspect cultur aborigin torr strait island peopl australia intrins connect good health wellb cultur knowledg exchang howev despit known import famili kinship network aborigin torr strait island cultur move toward famili centr approach healthcar servic provis valid nation measur famili function aborigin torr strait island peopl valid tool measur famili function necessari order better understand foster good famili function inform develop program healthcar intervent

D044468;D006303

T058;T098

36,307,795

preoper serum ca predict postop pancreat fistula pdac patient retrospect analysi singl institut postop pancreat fistula popf critic complic pancreatectomi patient pancreat ductal adenocarcinoma pdac recent paper report serum carbohydr antigen ca level predict long term prognosi investig whether preoper serum ca level associ popf pdac patient

D021441;D010190

T191

36,307,794

assess impact formal prepar activ perform univers clinic aptitud test ucat nation studi previous studi shown perform univers clinic aptitud test ucat associ measur candid socio econom advantag parent occup type school attend possibl access prepar support materi may part explain associ paper determin whether use formal prepar resourc associ higher ucat score whether differ use prepar resourc exist socio demograph group

D012577;D013337

T097;T073;T093

36,307,793

explor ident develop bud neuroscientist postgradu level mix method studi perspect alumni academ neurosci repres one excit frontier scientif research howev given recenc neurosci disciplin inter multi disciplinari natur lack educ research brain scienc train absenc nation global benchmark numer neurosci subfield develop academ neuroscientist ident across career stage remain obfusc neurosci predomin taught undergradu level present postgradu special accept graduat wide rang primari disciplin

D013334

T081;T098

36,307,792

worldwid cancer statist adult year old systemat analysi global burden diseas studi cancer becom one major killer human due number peopl age increas popul age aim studi analys incid mortal rate peopl cancer type countri region well trend

D000071219;D009369

T081;T191

36,307,791

one year outcom polym free amphilimus elut stent versus durabl polym zotarolimus elut stent patient diabet mellitus meta analysi diabet mellitus dm cardiovascular diseas often co exist today percutan coronari intervent pci prefer revascular procedur major patient coronari arteri diseas polym free amphilimus elut stent ae repres novel elut technolog current era drug elut stent analysi aim systemat compar cardiovascular outcom associ polym free amphilimus elut stent ae versus durabl polym zotarolimus elut stent zes treatment patient dm

D054855;D062645;D002317;D003324;D003920

T061;T121;T047;T074

36,307,790

gelma mxene hydrogel nerv conduit microgroov spinal cord injuri repair repair spinal cord injuri sci depend microenviron improv reconnect injur axon regener neuron fabric gelma mxene hydrogel nerv conduit electr conduct intern face longitudin groov explor function sci repair found result groov gelma mxene hydrogel could effect promot neural stem cell nscs adhes direct prolifer differenti vitro addit gelma mxene conduit load nscs gmn implant injur spinal cord site effect repair capabl complet transect sci demonstr gmn group show remark nerv recoveri signific higher bbb score comparison group therefor gmn microgroov structur load nscs promis strategi treat sci

D013119;D058953

T025;T037

36,307,789

high preval chronic malnutrit indigen children year age chimborazo ecuador multicaus analysi determin despit multipl initi implement reduc stunt ecuador continu public health problem signific preval one affect group rural indigen popul studi aim analyz preval chronic malnutrit indigen children year age associ health determin focus one territori highest preval stunt

D044342

T047

36,307,788

case control studi cypb gene polymorph suscept gastric cancer chines han popul china gastric cancer gc one common malign tumor studi aim explor relationship rs rs rs polymorph cypb suscept gc chines han popul

D013274

T191

36,307,787

motion artefact reduct coronari ct angiographi imag deep learn method aim studi investig abil pixel pixel generat adversari network gan remov motion artefact coronari ct angiographi ccta imag

D016477;D000077321

T068;T066

36,307,786

associ nutrient pattern hyperuricemia mediat analysi involv obes indic nhane diet long hypothes play import role hyperuricemia weight gain factor strong associ rise serum urat aim clarifi mediat role obes relationship diet hyperuricemia determin whether weight loss diet effect way prevent hyperuricemia

D033461

T047

36,307,785

examin influenc correl differ quantil surviv time infant mortal bangladesh sever studi identifi factor influenc infant mortal best knowledg studi assess factor consid unequ effect differ surviv time infant mortal bangladesh studi examin set covari behav differ quantil surviv time relat infant mortal

D007226;D001721

T081;T079

36,307,784

finit element analys later condyl fractur fixat paediatr regard configur kirschner wire studi aim discov stabl outcom among differ kirschner wire k wire configur fixat later condyl fractur milch type ii differ load stress use finit element analys fea

D006810;D010372

T091;T037

36,307,783

caus mortal risk older patient femor neck fractur mortal rate hip fractur high howev year mortal rate femor intertrochanter fractur femor neck fractur differ gibson smith klop c elder pj wels pm van schoor n leufken hg et al osteoporo int although type hip fractur previous real world singl center prospect cohort studi show older age high charlson comorbid index score risk factor femor intertrochanter fractur addit therapi zoledron acid mg aclasta protect factor li xp zhang p zhu sw yang mh wu xb jiang xy j orthop surg res wish determin risk factor caus mortal femor neck fractur patient

D005265;D006620;D005264

T037

36,307,782

associ statin progress osteoarthr featur magnet reson imag predomin pre radiograph cohort vancouv longitudin studi earli knee osteoarthr valseko cohort studi evalu effect statin use osteoarthr oa incidenceprogress use magnet reson imag mri popul base cohort predomin pre radiograph knee oa

D020370;D019161;D054850;D002358

T121;T047;T024;T109

36,307,781

effici secretori product prolinealanineserin pas biopolym corynebacterium glutamicum yield monodispers biolog altern polyethylen glycol peg pas biopolym recombin polypeptid compris small uncharg l amino acid pro ala andor ser resembl wide use poli ethylen glycol peg term pronounc hydrophil likewis random chain behaviour physiolog solut result strong expand hydrodynam volum thus apart use fusion partner biopharmaceut achiev prolong half life vivo pas biopolym appear attract substitut peg poor degrad chemic polym mani area prerequisit wide applic pas biopolym afford cost establish high effici biotechnolog product corynebacterium glutamicum serv well character bacteri host organ

D011392;D048230

T123;T007;T116

36,307,780

microaerob metabol lactat propion enhanc vitamin b product propionibacterium freudenreichii propionibacterium freudenreichii use biotechnolog applic produc vitamin b although cultur main anaerob condit microaerob condit great enhanc biomass format p freudenreichii sinc b yield may coupl biomass format microaerob condit show great potenti increas b yield p freudenreichii

D000070002

T007

36,307,779

digit support patient center asynchron outpati follow rheumatoid arthriti explor qualit studi steadili increas demand decreas number rheumatologist push current rheumatolog care limit long travel time poor access rheumatologist present particular challeng patient need adapt digit support patient center flexibl model care could contribut maintain high qualiti patient care qualit studi embed random control trial telera investig new model care consist use medic app epro electron patient report outcom self administ crp c reactiv protein test joint self examin rheumatoid arthriti ra patient qualit studi aim explor experi ra patient rheumatolog staff regard current care new care model

D001172;D012219

T047;T091