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36,307,778
role optic coher tomographi angiographi distinguish ischem versus non ischem central retin vein occlus observ macular microvascular chang patient ischem non ischem central retin vein occlus crvo optic coher tomographi angiographi octa explor valu octa differenti ischem non ischem crvo
D012170;D008269
T047;T046
36,307,776
e coli bacteraemia antimicrobi resist follow antimicrobi prescrib urinari tract infect communiti urinari tract infect one common infect primari secondari care major antimicrobi therapi initi empir cultur result avail case howev bacteria caus uti resist antimicrobi use yet know patient outcom affect term relaps treatment failur progress serious ill bacteraemia requir hospit ultim death studi analyz current pattern antimicrobi use uti communiti scotland factor poor outcom
D014552;D004927;D016470
T047
36,307,775
safeti pharmacokinet efficaci sct anti egfr monoclon antibodi patient wild type krasnrasbraf metastat colorect cancer phase dose escal dose expans studi express epiderm growth factor receptor egfr observ colorect cancer associ aggress diseas poor prognosi sct newli develop recombin fulli human anti egfr monoclon antibodi studi aim evalu safeti toler pharmacokinet pk efficaci patient wild type krasnrasbraf metastat colorect cancer mcrc method phase studi compris dose escal phase dose expans phase sct administr intraven group three six patient everi week dose cycl mgkg multipl dose schedul evalu blood sampl collect preset interv pk assess radiolog imag use efficaci assess continu safeti monitor perform group studi result decemb decemb fifti six patient wild type krasnrasbraf mcrc receiv dose sct evalu among patient fail least two prior line chemotherapi dose limit toxic occur group patient experienc treatment emerg advers event teae patient experienc treatment relat advers event trae patient grade trae serious trae observ common trae dermotox hypomagnesemia pk analysi show non linear pk rang mgkg singl dose sct clearanc decreas elimin half life prolong follow dose increas multipl dose period clearanc decreas peak concentr increas prolong prolong drug administr steadi state reach five consecut dose mgkg quaqu week qw object respons rate orr confid interv ci orr dose expans group mgkg qw ci median progress free surviv month ci median overal surviv month ci reach
D015179;D000970;D003110;D012004
T121;T191;T109
36,307,774
pressur pain threshold somatosensori abnorm differ age function condit post stroke elder somatosensori deficit abnorm pain sensit high preval among stroke survivor negat impact qualiti life recoveri process howev factor pressur pain threshold ppt somatosensori abnorm post stroke elder remain unknown aim studi explor effect age side function condit spastic motor function ppt sensori abnorm among elder stroke
D020521;D000071939
T061;T047
36,307,773
corf repres aberr genet program drive progress pdac pancreat ductal adenocarcinoma pdac constitut pancreat cancer fourth lead caus cancer relat death world lack earli detect pdac contribut poor prognosi patient often diagnos advanc stage diseas most due lack promis diagnost therapeut target correspond drug
D021441;D010190;D000230
T191
36,307,772
qualiti life mental health women cardiac diseas pregnanc postpartum cardiac diseas lead caus matern morbid mortal yet limit research women experi qualiti life qol outcom aim studi explor general health relat qol hrqol mental health outcom women experienc cardiac diseas pregnanc first month postpartum cdpp
D011788;D006331
T078;T047
36,307,771
effect aldh gluli polymorph vasovag syncop patient undergo head tilt test supplement sublingu nitroglycerin head tilt test hutt clinic advantag diagnos patient vasovag syncop vvs nitroglycerin main use stimul hutt mitochondri aldehyd dehydrogenas aldh involv metabol nitroglycerin ntg aldh gluli polymorph aldh rs common variant east asian popul studi aim assess effect aldh rs vvs patient undergo hutt supplement sublingu ntg hutt ntg method patient recurr vvs least time admit syncop center hospit enrol vvs patient undergon hutt polymorph gluli gene aldh measur dna microarray chip method result hutt ntg vvs patient differ aldh genotyp compar hemodynam characterist assess
D019462
T047
36,307,769
safeti efficaci interrupt dual antiplatelet therapi one month follow percutan coronari intervent meta analysi random control trial short durat dual antiplatelet therapi dapt follow percutan coronari intervent pci recent attract lot attent introduct newer generat stent appeal especi patient high bleed risk howev none trial power individu ischem bleed endpoint randomis control trial rcts investig one month versus routin durat dapt patient undergo pci report outcom time cessat dapt month year elig inclus meta analysi pool risk ratio rr confid interv ci calcul random effect model use mantel haenszel method four rcts involv patient includ meta analysi cessat dapt month associ signific less major bleed rr ci p heterogen statist signific differ caus mortal rr ci p stroke rr ci p compar routin durat dapt also differ myocardi infarct mi rr ci p definit probabl stent thrombosi rr ci p cessat dapt month cessat dapt month pci associ signific less major bleed differ rate caus mortal stroke mi stent thrombosi
D062645;D010975
T061;T121
36,307,768
sustain deliveri chabc improv function recoveri spine injuri chondroitinas abc chabc enzym could improv regener therebi improv function recoveri spinal cord injuri sci rodent model degrad activ enzym diffus away lesion caus use hydrogel scaffold deliv chabc lesion site meta analysi investig effect chabc embed scaffold hydrogel function recoveri sci
D019765;D013119
T126;T116;T037
36,307,767
oral health depress symptom among older adult urban china moder mediat model analysi studi explor associ oral health depress occur via daili dietari satisfact mediat bodi mass index could moder path daili dietari satisfact depress
D003863;D009909
T033;T184;T048
36,307,766
retrospect studi explor south african newspap frame schizophrenia psychot disord year period way schizophrenia portray media contribut dissemin misinform symptom caus treatment mental disord potenti perpetu mitig stigmat schizophrenia research news media role exacerb mitig stigmat schizophrenia conduct wide context search yield studi media frame schizophrenia south africa therefor studi use frame theori examin media frame schizophrenia follow enact two mental health polici south africa
D012559;D011618
T048
36,307,765
allopatri secondari contact differenti hybrid among three sympatr gentiana speci qinghai tibet plateau mountain world host signific portion terrestri biodivers region qinghai tibet plateau qtp stand one remark mountain region earth mani explos radiat occur qtp natur laboratori ideal investig pattern process link speciat diversif inde understand close relat sympatr speci diverg vital explor driver foster speciat topic rare investig qtp combin genom environment data explor speciat process among three close relat sympatr speci gentiana hexaphylla g lawrencei g veitchiorum qtp region
D030012
T002
36,307,764
intervent address function abil older peopl rural remot area scope review avail evid base function abil domain world health organ encourag healthi age strategi help develop maintain older peopl function abil five domain abil meet basic need learn grow make decis mobil build maintain relationship contribut societi scope review report avail evid base intervent undertaken peopl year age rural remot area outcom intervent relev enhanc function abil
D012424;D007858
T061;T098;T062;T102;T041
36,307,763
insertiondelet hotspot nsp nsp orf gene sar relat coronavirus genom sever acut respiratori syndrom coronavirus sar cov contain mani insertionsdelet indel genom sar relat coronavirus identifi indel recent report involv relat long segment consecut base divers rna sequenc around gap virus speci differ characterist classic shorter frame indel non classic complex indel identifi non structur protein nsp domain spike open read frame orf determin whether occurr non classic indel specif genom region ubiquit among broad speci sar relat coronavirus differ anim host present studi compar sar relat coronavirus human sar cov sar cov bat ratg rc pangolin gx pl perform multipl sequenc align result indel hotspot divers rna sequenc differ length virus confirm nsp gene approxim base posit overal base nsp gene approxim base posit n termin domain spike protein base posit orf gene base posit abnorm high rate point mutat complex indel region suggest occurr mutat hotspot may select neutral even benefit surviv virus presenc indel hotspot report differ human sar cov strain last year suggest lower rate indel human sar cov futur studi elucid mechan enabl frequent develop long complex indel specif genom region sar relat coronavirus would offer deeper insight process viral evolut
D045473;D000086382;D002685
T005;T015;T067;T047
36,307,762
frugal align free identif flt intern tandem duplic filtr intern tandem duplic flt gene term flt itd use molecular marker acut myeloid leukemia aml patient risk stratif follow flt itd increas screen high throughput sequenc hts rais need robust effici algorithm develop new algorithm perform align use littl resourc identifi quantifi flt itd hts data
D020080;D015470
T123;T191;T114
36,307,761
nutrient realloc stem leaf drive graze grassland degrad inner mongolia china declin height aboveground biomass plant communiti critic indic grassland ecosystem degrad nutrient realloc induc graze occur among differ organ balanc trade growth defens howev yet clear nutrient realloc strategi affect plant communiti structur function graze grassland graze experi conduct typic stepp inner mongolia china investig plant communiti characterist measur plant function trait domin speci leymus chinensi cleistogen squarrosa individu popul level carbon c nitrogen n phosphorus p copper cu iron fe manganes mn zinc zn concentr stem leaf two speci also determin
D065948;D017753
T070;T082
36,307,760
high densiti linkag map genet architectur genom predict growth wood properti pinus radiata grow avail genom resourc radiata pine pave way signific advanc fundament appli genom research construct robust high densiti linkag map base exom captur genotyp two f popul use popul perform quantit trait locus qtl scan genom predict quantit analys genet architectur key trait target tree improv programm
D028223
T002
36,307,759
distribut bioactiv gibberellin along peach annual shoot close associ ppgaox ppgaox express profil rapid growth annual shoot detriment peach product gibberellin ga promot rapid growth peach shoot limit inform ident express profil ga metabol gene speci
D000068239;D017360
T168;T002
36,307,758
studi protocol artifici intellig assist spong cytolog pre endoscopi screen earli esopheg squmaous epitheli lesion china endoscop screen wide accept screen strategi esophag squmaous cell carcinoma escc howev massiv endoscop screen expens cost effici novel pre endoscopi detect use preliminari screen method arous new concern plan launch artifici intellig ai assist spong cytolog detect esophag squmaous high grade intraepitheli neoplasia hgin lesion aim trail investig effici ai assist spong cytolog popul base screen earli esophag squmaous epitheli lesion
D002294;D004938;D002278
T191
36,307,757
characterist potenti function effect long insert asian butternut structur variant svs play import role adapt evolut speci diversif especi plant mani phenotyp respons environ found associ svs despit preval signific svs long insert remain poor detect studi model speci
D016678;D044466
T098;T028
36,307,756
perinat measur associ adolesc mental health retrospect explor origin data psychiatr cohort perinat marker prenat develop associ offspr psychiatr symptom howev littl research investig specif perinat marker develop specif disord studi aim explor perinat marker specif associ adolesc substanc use disord sud
D008603;D019966
T033;T041;T048
36,307,755
ultrasound guid bilater modifi thoracoabdomin nerv block perichondri approach tapa patient undergo laparoscop cholecystectomi random doubl blind control trial modifi thoracoabdomin nerv block perichondri approach tapa new techniqu provid effect analgesia anterior later thoracoabdomin wall administ local anesthesia undersid perichondr surfac primari purpos present studi investig postop analges efficaci tapa block perform surgeri patient undergo laparoscop cholecystectomi lc
D017081;D014147;D009407
T061;T121;T109
36,307,754
frailti postop urinari tract infect among older adult postop urinari tract infect associ signific harm includ increas risk hospit readmiss periop mortal risk urinari tract infect known increas age independ associ frailti postop urinari tract infect unknown studi use data us nation surgic qualiti improv program nsqip investig whether frailti independ risk factor postop urinari tract infect control age relev confound
D000073496;D014552
T033;T184;T047;T046
36,307,753
posit mental health canadian adult experienc childhood sexual abus explor role social support childhood sexual abus csa predict poorer mental health greater psychiatr disord risk lower posit mental health pmh adulthood outcom potenti moder social support current studi aim explor whether canadian adult experienc csa differ term pmh social support within csa sampl investig whether gender differ exist respect pmh social support particular social support subscal predict pmh
D012742;D001523;D002650
T037;T048
36,307,752
design decis data complet experi sampl method use psychosi systemat review experi sampl method esm intens longitudin research method particip complet questionnair multipl time current recent state design esm studi complex peopl psychosi shown less adher esm studi protocol general popul known design studi increas adher studi protocol lack typolog make hard research decid collect data way allow methodolog rigour qualiti report abil synthesis find aim systemat review characteris design choic made esm studi monitor daili live peopl psychosi synthesis evid relat data complet differ design choic
D000072860;D011618
T060;T048
36,307,751
novel stem hypoxia relat signatur prognost stratif immunotherapi respons hepatocellular carcinoma specif differenti potenti unlimit prolifer self renew capac cancer stem cell cscs close relat occurr recurr drug resist hepatocellular carcinoma hcc well hypoxia therefor depth analysi relationship hcc stem oxygen status effect immunotherapi necessari improv poor prognosi hcc patient
D006528;D008113
T191
36,307,739
autophagi game changer plant develop crop improv manipul autophag pathway repres tremend opportun design climat smart crop improv yield better adapt chang environ exploit autophagi full potenti identif comprehens character adaptersreceptor complex elucid regulatori network crop plant high warrant autophagi major intracellular traffick pathway eukaryot involv vacuolar degrad cytoplasm constitu mis fold protein defect organell optimum condit autophagi oper basal level maintain cellular homeostasi stress condit induc provid tempor stress relief understand high dynam process evolv exponenti past year special refer sever plant specif role autophagi review recent advanc field autophagi plant discuss potenti implic design crop improv stress diseas toler enhanc yield potenti improv capabl produc metabolit high econom valu also assess current knowledg gap possibl strategi develop robust modul biotechnolog applic autophagi enhanc bioeconomi sustain agricultur
D001343;D063245
T040;T038;T043
36,307,737
multipl metabolit model predict preliminari renal injuri induc iodixanol base uhplcq orbitrap ms h nmr problem unclear patholog mechan delay diagnosi inaccur therapeut target contrast induc acut kidney injuri ci aki signific import find biomark therapeut target indic renal injuri earli stage ci aki studi aim establish multipl metabolit model predict preliminari renal injuri induc iodixanol explor pathogenesi
D055432;D058186
T047;T091;T037
36,307,713
nhs fund dental undergradu human diseas teach uk year review introduct studi identifi fund nhs servic support dental student teach last year focus human diseas hd teachingaim identifi nhs fund educ uk dental school follow public general dental council curriculum introduc specif fund hd teach year materi method search medic literatur grey literatur govern regulatori author report legisl articl freedom inform request hospit help deliv teachingresult public describ current fund dental undergradu teach freedom inform request gave data nhs hospit alloc teach clinic dentistri hd hd fund drop million five yearsconclus nhs trust link dental school receiv moni deliv teach offset cost accommod student track fund year seen school lose million hd fund lose greater transpar regard fund hd deliveri would help improv teach increas number older patient greater chronic diseas burden retain teeth later life need graduat dentist good medic knowledg deliv safe care
D004497;D004504
T065
36,307,712
avoid psycholog traumatis dentistri work patient adult survivor child sex abus introduct seven percent adult popul uk includ one six women report unwant sexual experi age impact psycholog trauma follow child sexual abus csa creat difficulti mani survivor access dental care due fear remind abus power imbal dentist trigger traumat responsesaim analys report csa survivor perspect dental care offer suggest practicemethod qualit semi structur interview csa survivor generat data part broader studi investig trust trustworthi survivor profession relationship rang dental interact need survivor describ receiv dental treatment present transcript analys use nvivo softwar themat analysi methodologyresult three main theme identifi dental encount realli panic opportun disclos choic controlconclus first uk studi present qualit data csa survivor experi dental care survivor wish access dental care tailor support need amelior remind abus traumat stress trigger trauma inform care may address difficulti treatment dental staff adopt flexibl approach work collabor survivor facilit relat safeti pleas note paper survivor refer sexual abus children
D002650;D000067073;D002649
T048
36,307,711
childhood obes overcom fear healthier weight convers famili introduct clinician may find rais issu weight patient carer healthier lifestyl convers uncomfort fear experi caus offenc two cycl audit complet specialist paediatr dental servic ascertain whether healthier weight convers patient carersmateri method inclus criteria audit paediatr patient general anaesthet assess dental extract result dental cari gold standard set patient general anaesthet assess bodi mass index bmi calcul healthier weight convers patient carer famili signpost support necessaryresult result first cycl found patient bmi record record healthier weight convers patient result first cycl share way help healthi weight convers discuss second cycl carri signific improv made clinician calcul bmi patient healthier weight convers necessarydiscuss mani clinician voic calcul bmi healthier weight convers someth previous routin done often forget other state felt uncomfort bring topic way would nt offend patient parent avoid soconclus result audit strong encourag clinician continu calcul bmi found use tool introduc healthier weight convers necessari subject healthier weight need acknowledg dental set discuss famili non judgement sensit way paper aim guid clinician sensit broach subject children carer signpost extra support need
D063766;D003731;D018681
T033;T121;T047
36,307,710
understand impact covid dental antibiot prescrib across england minefield introduct covid pandem impact signific dental servic deliveri across englandobject explor pandem affect antibiot prescrib primari care dentistsmethod mix method studi secondari analysi routin collect nhs dental antibiot prescrib data pandem onlin survey dentist nhs privat across england regionsresult dental antibiot prescrib increas pandem first year region variat increas london east england dentist survey prescrib mani antibiot urgent dental centr requir antibiot accept referr irrespect clinic appropri diagnos remot hard antibiot use delay aerosol generat procedur fill gap servic widespread frustrat existeddiscuss maintain access urgent dental care futur pandem would includ avail high grade person protect equip dental team everyon must understand impact restrict dental access antibiot overprescrib henc antibiot resistanceconclus reduc dental access chang dental servic deliveri pandem increas antibiot prescrib ensur uninterrupt access effect urgent dental care import element global effort tackl antibiot resist
D000900;D000086382
T121;T047;T195;T067
36,307,700
dental manag patient sensori impair articl discuss differ type sensori impair aetiolog consid oral health status patient sensori impair impact disabl barrier patient face dental care also discuss legisl relev dental care profession care patient disabl includ mental capac act equal act access inform standard final provid recommend dental care profession best manag patient sensori impair communic effect order provid qualiti dental care
D006233
T101
36,307,699
broken needl rare complic inferior alveolar nerv block report two case introduct needl fractur deliveri local anaesthesia rare complic modern dentistri declin occurr advent dispos flexibl alloy still occur import clinician know deal complic manag lost needl pterygomandibular space give inferior alveolar nerv block proven dilemma past paper discuss minimis risk relev manag scenario examin two case needl fractur deliv inferior alveolar nerv blockdiscuss number structur present pterygomandibular space clinician cognis needl fractur remov immedi clinician prompt maxillofaci referr requir managementconclus rare needl fractur occur deliv inferior alveolar nerv block clinician awar minimis risk manag complic remov time prompt maxillofaci referr made
D009407;D005547;D000766
T061;T020;T037;T072
36,307,698
cardiff women inspir us cardiff univers school dentistri open remain origin site share univers hospit wale current admit around undergradu student per year bachelor dental surgeri student dental care profession postgradu student whilst school overal vision excel equit dental oral health educ research one key aim reach inclus welcom cultur ensur equal opportun staff student age ethnic disabl famili structur gender nation sexual orient race religion belief socio econom background develop deepli embed ingrain belief common school cultiv divers staff student bodi enrich student experi encourag innov teach research outward look staff
D004497
T065
36,307,697
opportun inclus human centr design challeng trend person centr care demograph shift technolog advanc transform oral health system inclus design human centr design disciplin high relev potenti instrument oral healthcar transform paper provid overview definit characterist inclus human centr design centr understand peopl multifacet need expect behaviour relationship engag divers often exclud popul design broad capabl outlin across outcom contribut type potenti role inclus human centr design oral health explor outlin relev key transform societ technolog shift final barrier driver adopt inclus human centr design oral health discuss around three theme awar understand role valu design disciplinari differ wider healthcar system context
D003695;D018802
T058;T093
36,307,673
blob marin heatwav transform california kelp forest ecosystem ocean warm direct physiolog indirect ecolog consequ marin organ sessil anim may particular vulner anomal warm given constraint food acquisit reproduct impos sessil temper reef ecosystem sessil suspens feed invertebr provid food array mobil speci act critic trophic link plankton bentho use year season benthic communiti data across five coastal reef evalu communiti sessil invertebr southern california kelp forest respond blob period anomal high temperatur low phytoplankton product show event prolong consequ kelp forest ecosystem chang communiti structur includ speci invas persist six year post blob suggest climat driven shift california kelp forest underway
D044423
T204
36,307,660
analyt mediat format growth nanoparticl develop chemic sensor biosensor cornerston nanomateri base sens system synthesi nanoparticl appropri surfac function ensur stabil determin reactiv organ inorgan analyt accomplish requir various compound use addit growth factor regul properti synthes nanoparticl reactiv target analyt differ rational use target analyt addit growth agent control format properti nanoparticl main differ analyt recognit event occur format nanoparticl base reactiv analyt precursor materi nanoparticl eg metal ion reduc agent coat transit ionic molecular state precursor materi order nanostructur assembl use sens signal transduct qualit detect quantit determin target analyt respect review focus assay base analyt mediat regul nanoparticl format differenti standard nanoparticl base assay reli pre synthes nanoparticl first principl analyt mediat nanomateri sensor describ discuss emphasi sens strategi signal transduct mechan applic final main advantag well limit approach discuss compar assay reli pre synthes nanoparticl order highlight major advanc accomplish type nano sensor elucid challeng opportun evolv new nano sens strategi
D015374;D053758;D049329
T059;T073;T075
36,307,597
neuroendocrin neoplasm imag protocol site origin relat low incid neuroendocrin neoplasm nen radiologist familiar optim imag techniqu imag protocol nen tailor site origin accur defin local extens nen time stage pattern spread recurr taken consider choos protocol detect recurr metastas paper present recommend ct mri imag protocol gastro enter pancreat nen base site origin predomin pattern metastat diseas explain rational mri contrast type contrast time well specif sequenc mri also briefli comment petct petmri imag protocol
D000072078;D018358
T060;T191
36,307,593
influenc transport process epidem threshold generat transient encount individu beyond immedi social environ transport profound impact spread epidem work consid epidem dynam presenc transport process give rise multiplex network model addit static layer multiplex epidem network consist second dynam layer two individu connect time occupi site random walk perform separ transport network develop mean field descript stochast network model studi influenc transport process epidem threshold show transport process general lower epidem threshold addit connect generat contrast consid also random walk fraction order sens realist model human mobil find non local transport dynam rais epidem threshold comparison classic local random walk also test model realist transport network munich u bahn network care compar mean field solut stochast trajectori rang scenario
D058872;D018562
T033;T046;T169;T067
36,307,592
anti drug antibodi sampl test report harmon clear scientif oper need exist harmon bioanalyt immunogen studi report facilit communic immunogen find expedi review industri health author address key bioanalyt report gap provid report structur document immunogen result cross industri group form establish harmon recommend develop submiss templat facilit agenc file provid recommend report clinic anti drug antibodi ada assay result use ligand bind assay technolog public describ essenti bioanalyt report bar element method critic reagent equip studi sampl result data analysi provid templat suggest structur ada bar public focus content present bioanalyt ada sampl analysi report interpret immunogen data includ evalu impact ada safeti exposur efficaci scope public
D000906
T129;T121;T116
36,307,570
affin microfluid enabl high throughput protein degrad analysi cell free extract protein degrad mediat ubiquitin proteasom pathway regul signal event mani physiolog patholog condit vitro degrad assay instrument understand cell prolifer fundament cellular process regul assay direct time specif high inform also labori typic reli low throughput polyacrylamid gel electrophoresi follow autoradiographi immunoblot present protein degrad chip pdoc mitomi base integr microfluid technolog discoveri analysi protein degrad cell free extract platform accommod hundr microchamb protein degrad assay quick simultan use minut amount reagent one mani physiochem environ essenti pdoc provid sensit multiplex altern convent degrad assay relev biomed translat research associ regul proteolysi
D044085
T090
36,307,549
droplet microfluid base high throughput bacteri cultiv valid taxon pair microbi co occurr network co occurr network infer abund data microbi communiti wide appli predict microbi interact howev high workload bacteri isol complex network constrain experiment demonstr predict microbi associ interact integr droplet microfluid bar code logist high throughput bacteri isol cultiv environment sampl experiment investig relationship taxon pair infer microbi co occurr network collect potamogeton perfoliatus plant includ root associ sediment beij olymp park wetland droplet seri dilut homogen wetland sampl inocul well plate contain ra tsb media day cultiv plate well show microbi growth select infer microbi co occurr network cultiv bacteri isol belong speci could repres zero level otus zotus infer co occurr network co cultiv bacteri isol correspond preval zotus pair network perform agar plate broth result suggest posit associ zotu pair co occurr network impli complic relat includ neutral competit mutual depend bacteri isol combin cultiv time
D044085;D064307
T001;T090;T032;T028
36,307,548
characterist circul adapt immun cell patient colorect cancer adapt immun cell prevent solid tumor progress target kill tumor cell howev comprehens studi peripher circul adapt immun cell character colorect cancer crc patient effect tumor node metastasi tnm stage cell studi number phenotyp function differ subset circul adapt immun cell peripher blood crc patient analyz found remark differ crc patient compar healthi control includ reduc absolut count total cell helper lymphocyt th cytotox lymphocyt tc doubl negat lymphocyt decreas proport inf cell total cell th increas percentag b cell plasmablast activ cell compar earli stage crc patient advanc stage crc patient show sever immunosenesc manifest decreas proport cd naiv cell strong prolif abil cd central memori cell immun surveil function proport absolut count cd cd termin differenti effector memori cell increas indic immunosenesc immun cell characterist analyz studi serv start point research determin potenti clinic implic
D015179;D000068884
T039;T191
36,307,545
live slow frozen human tumor tissu viabl ex vivo cultur singl cell rnaseq biobank surplus human healthi diseas deriv tissu essenti diagnost translat research enorm amount formalin fix paraffin embed ffpe tissu tek oct embed snap frozen tissu preserv mani biobank worldwid basi translat studi howev usag limit assay requir viabl cell access intact viabl human materi prerequisit translat valid basic research novel therapeut target discoveri function test show surplus tissu multipl solid human cancer direct slow frozen resect subsequ use differ type method includ establish ex vivo cultur well singl cell rna sequenc similar result compar fresh analyz materi
D005557;D009369
T121;T191;T131;T109
36,307,542
combinatori gene target primari human hematopoiet stem progenitor cell crisprca system offer enorm versatil function genom mani applic proven challeng primari human cell compar cell line mous cell establish paradigm multiplex gene edit primari human cord blood deriv hematopoiet stem progenitor cell hspcs use co deliveri lentivir sgrna vector express either enhanc green fluoresc protein egfp kusabira orang kuo togeth cas mrna simultan edit two genet loci fluoresc marker allow track either singl doubl edit cell could achiev robust doubl knockout cell surfac molecul cd cd effici function proof concept demonstr system use model gene depend cell surviv simultan target cohesin gene stag stag moreov show combinatori effect potenti synergi hspc expans target aryl hydrocarbon receptor ahr conjunct member corest complex taken togeth traceabl multiplex crisprca system enabl studi genet depend cooper primari hspcs import implic model polygen diseas well investig under mechan gene interact
D006412;D000072669
T063;T025
36,307,541
de novo assembl character draft genom cashew anacardium occidental l cashew second import tree nut crop global market cashew diploid heterozyg speci close relat mango pistachio improv convent breed slow due long juvenil phase despit econom import littl genomicstranscriptom inform avail cashew studi oxford nanopor read illumina read use de novo assembl cashew genom hybrid assembl yield mb genom correspond estim genom size mb busco analysi show genom complet transcriptom map show transcript align assembl genom gene predict result identif gene code total gene isoform mb cashew genom compris repetit sequenc phylogenet analys cashew nine speci show close relat mangifera indica analysi cashew genom reveal putat r gene first draft assembl genom transcriptom r gene inform generat studi would foundat understand molecular basi econom trait genom assist breed cashew
D031021
T168;T002
36,307,540
pde type diabet type diabet td incid increas covid infect children year age interferon activ oligoadenyl synthetas downstream rnasel activ degrad pathogen rna also damag host rna rnasel activ poor regul one regul pde degrad oligoadenyl unit therebi decreas rnasel activ analyz pde express islet non diabet donor individu newli median diseas durat day recent year diagnos td individu type diabet td also analyz pde singl nucleotid polymorph snps relat td incid pde express decreas individu recent diagnos td three five individu newli diagnos td individu td two rare pde snps found odd ratio td develop discuss whether decreas pde express covid infect might part fold increas td incid
D003922;D003924;D000086382
T047;T067
36,307,539
bioactiv vegf c e coli vascular endotheli growth factor c vegf c stimul lymphat vessel growth transgen model via viral gene deliveri recombin protein express eukaryot protein like vegf c bacteri cell limit cell lack specif posttransl modif provis disulfid bond format howev given cost time save associ bacteri express system consider valu express vegf c use bacteri cell identifi two approach result biolog activ escherichia coli deriv vegf c expect vegf c express truncat cdna becam bioactiv vitro fold inclus bodi given vegf c one cystein richest growth factor human unclear whether known method facilit correct cystein bond format allow direct express bioactiv vegf c cytoplasm fuse vegf c maltos bind protein express fusion redox modifi cytoplasm origami de strain could recov biolog activ delet mutant lack propeptid vegf c first report bioactiv vegf growth factor obtain e coli cell circumv vitro fold
D004926;D042582
T123;T007;T116
36,307,538
design character urea bridg pmo support cu ii nanoparticl high effici heterogen catalyst synthesi tetrazol deriv work new period mesopor organosilica urea bridg produc reaction aminopropyl triethoxysilan toluen diisocyan ap tdu pmo introduc obtain ap tdu pmo found appropri support load cu ii nanoparticl afford supramolecular cu ap tdu pmo nanocomposit uniform mesoporos synthes nanomateri includ ap tdu pmo cu ap tdu pmo prove differ spectroscop microscop analyt techniqu includ ftir edx xrd fesem tem bet tga dta furthermor prepar cu ap tdu pmo nanomateri also use heterogen recycl catalyst synthesi tetrazol deriv cascad condens concert cycloaddit tautomer reaction inde main advantag cu ap tdu pmo simpl prepar high catalyt activ well proper surfac area enabl work solvent free condit also introduc cu ap tdu pmo heterogen catalyst show good stabil reusabl six consecut run address green chemistri principl
D053761;D053758
T073
36,307,536
multi level cellular function annot singl cell transcriptom use scpipelin singl cell rna sequenc scrna seq offer function insight complex biolog allow interrog cellular popul gene express program singl cell resolut introduc scpipelin singl cell data analysi toolbox build exist method offer modular workflow multi level cellular annot user friend analysi report advanc scrna seq annot includ co depend index cdi base differenti express ii cluster resolut optim use marker specif criterion iii marker base cell type annot miko score iv gene program discoveri use scale free share nearest neighbor network ssn analysi unsupervis supervis procedur valid use divers collect scrna seq dataset illustr exampl cellular transcriptom annot development immunolog scrna seq atlas provid herein overal scpipelin offer flexibl comput framework depth scrna seq analysi
D059467;D020869
T081;T063;T059;T086
36,307,532
reliabl measur muscl volum use magnet reson imag typic develop infant two rater assess intra rater inter rater reliabl manual segment magnet reson imag mri vivo measur infant muscl volum knee extensor flexor muscl two rater muscl knee extensor flexor muscl ten typic develop infant day day scan mri proton densiti sequenc scan segment use slicer softwar volum render two rater intra rater inter rater reliabl assess use intra class correl icc mean differ md standard error mean sem minim detect chang mdc muscl calcul icc intra rater reliabl segment process muscl volum muscl knee extensor flexor muscl respect inter rater reliabl knee extensor flexor muscl respect intra rater reliabl md cm mdcs cm inter rater md cm mdcs cm muscl mri segment muscl volum show good excel reliabl though given small volum muscl variat rater amplifi care taken report interpret infant muscl volum
D008279;D018482
T024;T060;T059;T170;T023
36,307,529
investig associ cognit apprais emot regul symptom posttraumat stress disord among asian american european american trauma survivor studi investig whether associ emot regul cognit apprais symptom posttraumat stress disord ptsd differ asian american european american trauma survivor asian american n european american n trauma survivor recruit mturk complet line questionnair assess cognit apprais emot regul ptsd symptomatolog european american group report greater trauma specif rumin psycholog inflex seek other comfort negat self apprais asian american group asian american group report greater secondari control apprais cultur belief advers european american group second cultur group moder associ brood rumin b fatal c self blame negat communal self apprais ptsd symptom associ larger european american group asian american group third indirect pathway self construal independ interdepend ptsd symptom certain emot regul approach cognit apprais addit cultur group found moder sever indirect effect find highlight import consid cultur background cultur valu understand process involv ptsd research area need
D013313;D000080103
T041;T048
36,307,528
matern pre pregnanc obes offspr hyperact inattent symptom year preterm term children multi cohort analysi object studi determin relationship matern pre pregnanc bodi mass index bmi child hyperact inattent symptom year includ preterm term born children determin whether associ vari gestat age matern pre pregnanc bmi offspr assess particip born week gestat elf cohort children born week epipag cohort report pre pregnanc weight kg measur height collect mother inclus use classifi bmi kgm child evalu use strength difficulti questionnair around year age logist regress estim odd ratio high score th percentil elf cohort general estim equat use epipag account non independ multipl birth negat control patern bmi also consid exposur interest sensit analys matern pre pregnanc obes overweight associ child year elf adjust aor obes overweight aor pre pregnanc obes associ high score preterm infant epipag aor elf magnitud associ increas decreas gestat age interact p high matern pre pregnanc bmi associ greater likelihood high score term preterm children year age
D050177;D000079262
T033
36,307,527
allevi advers effect salin rosell plant green synthes nanoparticl present studi eco friend process made rapid synthesi silver nanoparticl use aqueous leaf extract hibiscus sabdariffa process character fourier transform infrar ft ir scan electron microscopi sem transmiss electron microscopi tem uv visibl x ray diffract xrd green silver nanoparticl nps use mitig advers effect salin seed germin growth paramet plant accord two experi conduct first experi seven concentr green silver nps nine level nacl cacl appto seed germin effect evalu second experi three concentr green silver nps nacl hypothes affect plant growth paramet seed germin plant height leaf root fresh dri weight well relat water content rwc decreas signific salt stress howev green silver nps interven allevi advers effect stress accord green silver nps benefici due activ antioxid system enhanc antioxid enzym catalas cat ascorb peroxidas apx peroxidas pod superoxid dismutas sod increas amount prolin solubl sugar carbohydr osmoprotect improv flavonoid anthocyanin content real time pcr show flavonoid anthocyanin content increas higher express chalcon synthas chs flavanon hydroxylas fh anthocyanidin synthas an gene conclus green silver nps offer eco friend applic research agricultur develop
D031584;D053768
T073;T002
36,307,524
anthropogen pollut gradient along mountain river affect bacteri communiti composit genera potenti pathogen speci mountain region poland among frequent visit tourist destin caus signific anthropogen pressur put local river studi base number microorgan content antibiot physicochem paramet determin pollut gradient six site along biaka typic mountain river southern poland ecolistaphylococcus ratio vari evid pollut non pollut site indic possibl util paramet assess anthropogen impact river ecosystem worth investig use next generat sequenc assess chang bacteri communiti structur divers respons pollut gradient proteobacteria bacteroidet abund phyla major sampl actinobacteria abund pristin groundwat sampl firmicut verrucomicrobia preval pollut site bacteri divers various level increas water pollut eleven bacteri genera potenti contain pathogen speci detect examin sampl among acinetobact rhodococcus mycobacterium frequent speci level acinetobact johnsonii preval potenti pathogen detect surfac water sampl includ pristin one two bacteri taxa genus flectobacillus order clostridial show distinct variat relat abund pollut non pollut site indic possibl potenti biomark anthropogen impact mountain river water
D045483;D017753
T070;T082
36,307,523
covid year life lost yll save yls express role vaccin evalu vaccin efficaci convent measur includ reduct risk hospit death number patient die without vaccin often public spotlight howev evalu public health intervent burden diseas illustr use mortal metric take account also prematur death year life lost yll year life save yls thank vaccin develop approach evalu differ yll yls covid victim without complet vaccin autumn pandem wave octob decemb czechia analysi individu data covid death countri n studi period use death cohort complet vaccin correspond year life lost role vaccin express use yls hypothet number death regist number death approxim time lower would expect without vaccin result illustr vaccin effect save live suggest simplist comparison
D000086382
T047;T067
36,307,522
dysregul transform growth factor beta mediat earli bone marrow dysfunct diabet diabet affect select organ eye kidney heart brain recent studi show diabet also enhanc adipogenesi bone marrow reduc number marrow resid vascular regen stem cell current studi perform detail spatio tempor examin identifi earli chang induc diabet bone marrow show short term diabet caus structur molecular chang marrow includ enhanc adipogenesi tibia mice prior stem cell deplet enhanc adipogenesi associ suppress transform growth factor beta tgfb signal use human bone marrow deriv mesenchym progenitor cell show tgfb pathway suppress adipogen differenti tgfb activ kinas tak find may inform develop novel therapeut target patient diabet restor regen stem cell function
D059630;D003920
T047;T025
36,307,521
protein requir hair sheep rais warm area multi studi approach protein requir hair sheep key factor increas profit decreas environment impact nitrogen excret object studi evalu protein requir hair sheep databas individu record intact castrat male compris inform studi use studi provid differ level metabolis protein intak mpi n retent allow develop equat predict net protein np metabolis protein mp requir effici mp use gain k pg calcul use equat daili protein retain daili mpi mainten effici mp use mainten k pm comput ratio np mainten npm mp mainten mpm npm gkg ebw differ sex k pm k pg mpm estim gkg bw sex affect protein requir gain npg protein requir hair sheep differ recommend feed system sheep equat provid herein may improv optimis protein nutrit sheep therebi minimis environment impact sheep product
D000824;D004044
T040;T116
36,307,519
viral metagenom reveal persist well dietari acquir virus antarct fur seal virus link anim inhabit antarct latitud remain poor studi remot environ host larg pinnip popul may prone exposur immunolog nave anim new infecti agent due increas human presenc introduct new anim speci antarct fur seal arctocephalus gazella inhabit western antarct peninsula south shetland island challeng climat chang increas anthropogen activ present studi fecal serum virom gazella character appli target enrich next generat sequenc result virom domin cress dna sequenc virus known infect vertebr invertebr host also observ fecal sampl fur seal picornavirus present fecal pool studi suggest preval virus speci six differ virus present similar previous describ gazella virus otariid mammal virus identifi potenti new gazella virus also diet deriv virus crustacean virus present fecal content penguin virus fish virus also detect obtain result contribut better understand viral communiti present speci relev conserv
D046069;D014780
T005;T015
36,307,518
develop autom machin learn pipelin detect alzheim diseas although alzheim diseas preval form dementia treatment capabl slow diseas progress lack reliabl diseas endpoint andor biomark contribut part absenc effect therapi use machin learn analyz eeg offer possibl solut overcom mani limit current diagnost modal develop logist regress model accuraci address mani shortcom previous work knowledg studi abl solv follow problem simultan lack autom unbias remov artifact depend high level expertis data pre process ml non autom process need larg sampl size accur eeg sourc local use high densiti system relianc black box ml approach deep neural net unexplain featur select studi present proof concept autom scalabl technolog could potenti use diagnos ad clinic set adjunct convent neuropsycholog test thus enhanc effici reproduc practic ad diagnosi
D000544
T047;T048
36,307,516
share mechan crosstalk covid osteoporosi via vitamin recent accumul evid implic close associ vitamin vitd insuffici incid clinic manifest covid caus sever acut respiratori syndrom coronavirus sar cov popul insuffici vitd includ patient osteoporosi suscept sar cov infect patient covid worsen develop osteoporosi current unknown howev whether osteoporosi covid link vitd insuffici studi common target vitd covid osteoporosi identifi among total vitd target bioinformat analysi reveal core target egfr ar esr mapk mdm ezh erbb mapt vitd covid osteoporosi network target involv erbb mapk signal pathway critic lung fibrosi bone structur integr cytokin crosstalk covid osteoporosi via vitd mediat convent immun osteoimmun mechan molecular dock confirm vitd bind tight predict target find support vitd may target common signal pathway integr network lung fibrosi bone structur integr well immun system therefor vitd may serv prevent therapeut agent covid osteoporosi
D000086382;D014808;D011658;D010024
T047;T067
36,307,515
identifi impact rainfal variabl conflict month level research relationship rainfal variabl conflict yield contradictori result studi first show signific impact rainfal variabl conflict depend tempor unit analysi prove point compar statist signific linkag georeferenc conflict rainfal variabl month annual level panel data analys find percent increas month rainfal decreas risk conflict incid percent annual rainfal variabl statist link conflict outbreak statist signific dispar result aggreg data dispers disregard time impact rainfal conflict find highlight import inform month rainfal variat estim impact rainfal conflict
D004196;D011891
T070;T067
36,307,514
assess exposur select smoke constitu adult smoker use market heat tobacco product random control studi object clinic studi demonstr reduct exposur select harm potenti harm constitu hphcs japanes healthi adult smoker switch four market heat tobacco product eighti nine smoker random assign five day one six studi group four group switch one commerci avail heat tobacco product group continu smoke brand combust cigarett cc group stop smoke ss fifteen biomark exposur boe hphcs pyren measur baselin day day h urin breath clinic confin product consumpt nicotin uptak subject effect also measur product switch day signific reduct boe relat cc group observ switch heat tobacco product chang boe observ baselin day cc group signific magnitud reduct exposur select hphcs observ heat tobacco product group close observ ss group
D066300;D062789
T131;T073;T109
36,307,513
polygen health index general health pleiotropi sibl analysi diseas risk reduct construct polygen health index weight sum polygen risk score major diseas condit includ eg coronari arteri diseas type diabet schizophrenia etc individu weight determin popul level estim impact life expect valid index odd ratio select experi use unrel individu sibl pair trio uk biobank individu higher index score decreas diseas risk across almost diseas signific risk increas longer calcul life expect estim disabl adjust life year dali use perform metric gain select among ten individu highest index score vs averag found rough dali find statist evid antagonist trade off risk reduct across diseas correl genet diseas risk found most posit general mild result import implic public health also fundament issu pleiotropi genet architectur human diseas condit
D003922;D003924
T047
36,307,512
neural network detect soccer header wearabl sensor data investig propos associ soccer head deleteri brain chang accur quantif head exposur crucial wearabl sensor constitut popular mean task avail system typic overestim number header poor discrimin true impact spurious record studi investig util neural network automat detect soccer header kinemat time seri data obtain wearabl sensor match femal soccer player wore head impact sensor regist field impact event g label valid header vh non header nh upon video review ground truth data subset use train valid long short term memori lstm neural network order classifi sensor record either vh nh base characterist linear acceler featur test balanc dataset compris vhs nhs correspond ground truth vhs nhs respect network show good overal classif perform reach score across metric test perform unbalanc dataset compris vhs nhs ie ground truth vhs nhs respect typic obtain real life set model still achiev sensit specif precis would result overestim soccer player true head exposur although classif perform suffer consider class imbal actual header non header studi demonstr general abil data driven deep learn network automat classifi soccer header base linear acceler profil
D012916;D000076251
T056;T073
36,307,511
integr learn algorithm earli predict melon harvest differ model techniqu must appli manag product statist estim predict expect harvest calcul advanc product method ration valuat differ factor accur captur varieti growth characterist expect yield paper obtain featur variabl relat melon includ phenolog featur shape featur color featur gradient boost decis tree gbdt network grid search gs hyperparamet seek method appli calcul degre import melon fruit characterist construct predict model three expect harvest index melon yield sugar content endocarp hard facilit grower carri predict estim field without destroy melon fruit reduc featur variabl select input gbdt model use provid signific advantag predict compar random forest rf support vector regress svr method addit verifi feasibl use reduc featur variabl input evalu work studi also compar predict effect model featur variabl reduc featur variabl use gbdt predict model propos paper predict melon yield sugar content hard use reduc featur input model r could reach therefor method effect help grower carri earli non destruct inspect growth predict melon field
D019662
T168;T002
36,307,510
opinion amplif caus extrem polar social network extrem polar opinion fuel mani problem face societi today issu human right environ social media provid vehicl opinion enabl spread idea faster ever previous comput model suggest signific extern event induc extrem polar introduc social opinion amplif model soam investig altern hypothesi opinion amplif result extrem polar soam model effect sensate hype fake news peopl express amplifi version actual opinion motiv desir gain greater follow show first time simpl idea result extrem polar especi degre amplif small show extrem polar prevent two method prevent individu amplifi five time consist dissemin balanc opinion popul natur tri loudest voic crowd seek attent work suggest instead shout heard generat uproar better speak moder
D060756;D061108
T098;T170;T054
36,307,509
deeplpi novel deep learn base model protein ligand interact predict drug repurpos substanti cost new drug research develop consist pose huge burden pharmaceut compani patient order lower expenditur develop failur rate repurpos exist approv drug identifi interact drug molecul target protein base comput method gain grow attent propos deeplpi novel deep learn base model main consist resnet base dimension convolut neural network cnn bi direct long short term memori network bilstm establish end end framework protein ligand interact predict first encod raw drug molecular sequenc target protein sequenc dens vector represent go two resnet base cnn modul deriv featur respect extract featur vector concaten fed bilstm network follow mlp modul final predict protein ligand interact download well known bindingdb davi dataset train test deeplpi model also appli deeplpi covid dataset extern evalu predict abil deeplpi benchmark model compar deeplpi baselin method deepcda deepdta observ deeplpi outperform method suggest high accuraci deeplpi toward protein ligand interact predict high predict perform deeplpi differ dataset display high capabl protein ligand interact general demonstr deeplpi potenti pinpoint new drug target interact find better destin proven drug
D000077321;D000086382
T047;T067;T066
36,307,508
wildtyp heterogen contribut clonal variabl genom edit cell genom edit tool crisprca enabl rapid precis manipul genom crispr base genom edit great simplifi studi gene function cell line widespread use also highlight challeng reproduc phenotyp variabl among differ knockout clone gene common problem confound establish robust genotyp phenotyp correl optim genom edit protocol enhanc reproduc includ measur reduc target effect howev even current state art protocol appli phenotyp variabl frequent observ identifi heterogen wild type cell import often neglect confound factor genom edit experi demonstr isol individu wild type clone appar homogen stabl cell line uncov signific phenotyp differ clone strike observ hundr differenti regul transcript downregul compar two popul wild type cell furthermor show varieti cellular biochem alter differ wild type clone rang common interpret biolog relev genom edit cell heterogen wild type cell thus contribut variabl genom edit cell generat isol clone show generat monoclon isogen wild type cell prior genom manipul reduc phenotyp variabl therefor propos generat match isogen control cell prior genom edit increas reproduc
D064113;D000072669
T063;T040
36,307,507
analysi non small cell lung cancer miliari lung metastasi patient harbor epiderm growth factor receptor mutat miliari lung metastasi uniqu featur lung metastasi non small cell lung cancer nsclc indic hematogen dissemin studi report frequenc epiderm growth factor receptor egfr mutat wors prognosi patient case identifi chi mei medic center cancer registri period inclus criteria nsclc contra later lung metastasi harbor egfr mutat tyrosin kinas inhibitor tki prescript patient miliari non miliari lung metastasi enrol surviv analysi nsclc patient enrol assess time discontinu tki td tki progress free surviv pfs overal surviv os patient miliari lung metastasi averag month confid interv ci td tki month ci pfs month ci os shorter non miliari group margin statist signific multivari analysi miliari lung metastasi statist signific strong prognost indic found includ perform status liver metastasi egfr type generat tki nsclc patient harbor egrf mutat tki prescript miliari lung metastasi domin indic outcom evalu
D002289;D008175
T191
36,307,506
discov hiv relat inform mean associ rule machin learn acquir immunodefici syndrom aid still one main health problem worldwid therefor essenti keep make progress improv prognosi qualiti life affect patient one way advanc along pathway uncov connect disord associ hivaid anticip possibl mitig propos achiev use associ rule ar allow us repres depend number diseas specif diseas howev classic techniqu systemat generat everi ar meet minim condit data frequenc henc generat vast amount uninterest ar need filter lack manual annot ar favor unsupervis filter even though produc limit result paper propos semi supervis system abl identifi relev ar among hiv relat diseas minim amount annot train data system abl extract good number relationship hiv relat diseas previous detect literatur scatter often littl known furthermor number plausibl new relationship shown deserv investig qualifi medic expert
D000163;D015658
T047
36,307,505
effect use spirulina alga methyl ester perform diesel engin chang compress ratio experiment investig diesel engin characterist investig experiment ad differ concentr third generat biodiesel spirulina alga methyl ester three volumetr blend ad standard iraqi diesel name properti fuel found accord american societi test materi standard astm experiment work conduct singl cylind diesel engin variabl load compress ratio three compress ratio use start base result obtain presenc along diesel caus increas brake specif fuel consumpt bsfc carbon dioxid co nitrogen oxid x decreas brake thermal effici bte exhaust gas temperatur egt hydrocarbon hc emiss decreas respect compar origin neat diesel fuel dramat carbon monoxid co emiss reduct full load point addit report decreas co nox well co emiss increas result addit compress ratio chang led increas bte nox decreas bsfc carbon emiss experiment result valid studi find minor diverg report
D053545
T007
36,307,504
smoke modul differ secretori subpopul express sar cov entri gene nasal bronchial airway sar cov infect diseas sever influenc viral entri gene express pattern airway epithelium similar differ gene express ace tmprss ctsl across nasal bronchial compart fulli character use match sampl larg cohort gene express data nasal bronchial brush obtain individu particip lung cancer screen diagnost workup reveal smoke status current versus former clinic factor signific reproduc associ gene express express ace tmprss higher smoker bronchus nose scrna seq nasal brush indic ace co express gene high express club corf secretori cell tmprss co express gene high express keratin epitheli cell contrast ace tmprss modul high express goblet cell scrna seq bronchial brush cell type deconvolut gene express data confirm smoke increas abund sever secretori cell popul bronchus goblet cell nose associ ace tmprss smoke bronchus due high express goblet cell increas abund current smoker airway contrast nose gene predomin express cell popul modul smoke individu elev lung cancer risk smoke induc gene express chang nose like minim impact sar cov infect bronchus smoke may lead higher viral load sever diseas
D000086382;D008175
T047;T191;T067
36,307,503
optim multipl vitro activ potenti carotenoid marin kocuria sp ram marin pigment bacteria promis natur sourc carotenoid kocuria sp ram isol red sea bohadschia graeffei collect marsa alam egypt use carotenoid product extract carotenoid purifi thin layer chromatographi tlc characterist uv absorb three purifi fraction gave us inkl purifi pigment chemic structur confirm nuclear magnet reson spectroscopi nmr lc esi qtof msms three differ red pigment identifi two c carotenoid name bisanhydrobacterioruberin trisanhydrobacterioruberin addit tetrahydrospirilloxanthin c carotenoid kocuria sp ram carotenoid investig multipl activ includ antimicrobi anti inflammatori antioxid anti hsv anticanc antidiabet wound heal new observ suggest kocuria sp ram carotenoid use distinct natur pigment potent properti
D002338;D008835
T123;T121;T007;T109
36,307,502
impact esophag devic insert cuff pressur endotrach tube literatur review meta analysi impact intraop esophag devic insert edi endotrach tube et cuff inflat pressur remain unclear electron databas includ medlin embas googl scholar web scienc cochran central regist control trial search studi involv edi placement et incept juli primari outcom risk high cuff pressur secondari outcom increas cuff pressur follow edi differ adult children investig subgroup analysi ten elig studi observ studi n random control studi n involv total particip edi notabl increas risk high cuff pressur n risk ratio confid interv subgroup analysi p signific elev cuff pressur adult children cmh respect subgroup analysi p cmh respect subgroup analysi p edi result reveal fold increas risk high endotrach tube cuff pressur patient especi adult receiv edi endotrach anesthesia signific increas adult children despit higher increas former devic insert
D007442;D014132
T061;T023
36,307,501
global genom methyl relat degre parasit cattl object present studi character herd angus nellor heifer identifi resist resili suscept anim parasit relat overal dna methyl anim degre parasit evalu egg count per gram fece epg haematobia irritan count horn fli rhipicephalus microplus count bovin tick experi carri complet random design contain treatment anim consid treatment repetit collect within year consid repetit data obtain count evalu parasit subject statist analysi use sisvar program classifi heifer accord degre parasit low resist intermediari resili high suscept parasit load infect nematod infest tick fli addit anim three group hierarch group use gene program heifer classifi degre parasit three parasit along dna methyl content anim group negat relationship observ resist methyl dna content classif resist resili suscept anim show highest intermedi lowest methyl dna quantif respect thus methodolog use herein enabl classif heifer accord degre collect infect gastrointestin nematod infest tick horn fli therebi establish link degre parasit resist cattl global methyl dna quantif
D002418;D009117;D048494
T047;T204
36,307,499
fit correct block model creat maximum entropi data driven spatial social network model network play major role explain reproduc empir observ pattern suitabl model use random observ network preserv featur generat synthet graph whose properti may tune upon characterist given popul present paper introduc fit correct block model adjust densiti variat well known degre correct block model show propos construct yield maximum entropi model network spars deriv analyt express degre distribut model depend constraint chosen fit distribut model perfect suit defin maximum entropi data driven spatial social network block identifi vertic similar posit eg resid age expect block block adjac matrix infer avail data case spars regim approxim coincid phenomenolog model probabl link bind two individu direct proport sociabl typic cohes age group wherea decay invers power geograph distanc support analyt find simul styliz urban area
D000465;D060756
T098;T170;T054
36,307,498
biosynthet regulatori network flavonoid metabolit stem leav salvia miltiorrhiza flavonoid secondari metabolit treat prevent mani diseas systemat studi regul biosynthesi metabolit aboveground part salvia miltiorrhiza lack studi metabonom transcriptom analys differ miltiorrhiza phenotyp conduct explor pathway synthesi catalysi accumul transport main flavonoid secondari metabolit regul pigment accumul tissu local quantit analysi flavonoid secondari metabolit conduct laser scan confoc microscopi lscm total differenti express gene obtain full length unigen purpl green phenotyp function gene involv flavonoid biosynthesi five key phenylpropan structur gene pal cl an hct high differenti express four transcript factor gene myb wrki bhlh bzip identifi addit six gst gene nine abc transport mate gene three snare gene detect key role flavonoid transport accord lscm flavonoid main distribut epidermi cortex collenchyma thus comprehens systemat analys use determin biosynthesi accumul transport flavonoid stem leav differ miltiorrhiza phenotyp find provid refer flavonoid product cultivar select
D027561
T002
36,307,497
real time monitor dynam interact bacteria earli stage format biofilm bacteri biofilm complex coloni bacteria adher static surfac andor one anoth bacteri biofilm exhibit high resist antimicrobi agent caus life threaten nosocomi infect despit effort scientif communiti investig format growth bacteri biofilm preliminari interact bacteria surfac subsequ earli stage format biofilm still unclear studi present real time label free monitor interact escherichia coli pseudomona aeruginosa bacteria untreat glass control surfac surfac treat benzalkonium chlorid chemic compound known antimicrobi properti proof principl investig perform standard invert optic microscop exploit optic phenomenon caustic tool monitor bacteri diffus earli adhes associ viabil enhanc resolv power optic set allow monitor character dynam bacteria provid evid relationship bacteri adhes dynam viabil well abil form biofilm viabl bacteria adher surfac exhibit notic slide rotari dynam bacteria kill surfac contact remain static adher surfac differ dynam allow earli detect biofilm format offer potenti quantifi effici antimicrobi surfac coat
D018441;D001422
T040;T007
36,307,496
preval clinic associ sarcopenia among thai patient system sclerosi patient system sclerosi ssc potenti factor associ increas risk sarcopenia current studi examin associ ssc patient aim determin preval sarcopenia among ssc patient examin associ clinic manifest laboratori test cross section studi conduct adult ssc patient scleroderma clinic khon kaen univers thailand juli april clinic data laboratori test inflammatori marker serolog hormon bodi composit dual energi x ray absorptiometri handgrip strength function lower extrem strength usual gait speed collect measur sarcopenia defin accord criteria asian work group sarcopenia one hundr eighti patient recruit nineti four case diffus cutan ssc subset respect mean age durat diseas year sarcopenia reveal ssc patient preval ci preval higher patient diffus cutan ssc dcssc compar limit cutan ssc bmi onset ssc c reactiv protein mgdl signific associ sarcopenia respect ci sarcopenia common patient ssc preval pronounc dcssc inflammatori marker particular crp level strong associ bmi onset negat associ sarcopenia among ssc patient
D055948;D012595;D045743
T047
36,307,495
real time covid detect via graphit oxid base field effect transistor biosensor decor ptpd nanoparticl coronavirus covid spread extrem infecti diseas specif treatment covid virus rapid unexpect spread rate result critic difficulti public health unpreced daili life disrupt thus accur rapid earli diagnosi covid virus critic maintain public health safeti graphit oxid base field effect transistor go fet fabric function covid antibodi purpos real time detect covid spike protein antigen thermal evapor process use deposit gold electrod surfac sensor substrat graphit oxid channel place gold electrod bimetal nanoparticl platinum palladium generat via ultra high vacuum uhv compat system sputter inert gas condens techniqu biosensor graphit oxid channel immobil specif antibodi covid spike protein achiev select specif techniqu use attract semiconductor characterist graphit oxid base materi result high specif sensit detect covid spike protein go fet biosensor decor bimetal nanoparticl platinum palladium investig improv sensor sensit hous develop biosensor limit detect lod fgml covid spike antigen phosphat buffer salin pbs moreov magnet label sar cov spike antibodi studi investig enhanc sensor perform result indic success fabric promis field effect transistor biosensor covid diagnosi
D006108;D000086382;D015374;D053758
T073;T067;T109;T075;T196;T059;T047
36,307,494
bulk segreg transcriptom analysi pea identifi key express marker resist peyronellaea pinod peyronellaea pinod devast pathogen pea crop quantit trait loci qtl associ resist identifi well gene differenti express resist suscept pea line key question mani gene locat qtls differenti express key gene distinguish resist suscept plant could use marker identifi key gene present studi appli mace massiv analysi cdna end seq whole recombin inbr line popul segreg resist diseas parent line identifi gene express correl level resist also compar gene express profil resist suscept famili ril popul total transcript differenti express parent line inocul show express pattern bulk form resist suscept ril famili gene show consist express pattern could use express marker distinguish resist suscept plant analysi gene also discov crucial mechan act p pinod
D018532;D001203
T168;T004;T002
36,307,493
effect oligo fucoidan immun respons inflammatori status pulmonari function patient asthma random doubl blind placebo control trial asthma common diseas occur worldwid clinic treatment asthma constant revis updat howev associ side effect previous vitro ex vivo studi found oligo fucoidan improv allerg immun respons reduc airway inflamm purpos clinic trial investig effect oligo fucoidan immun status inflammatori respons pulmonari function patient asthma twenti asthmat patient random divid two group control group receiv regular asthma treatment supplement placebo fucoidan group receiv regular asthma treatment supplement oligo fucoidan pulmonari function test asthma control questionnair survey biochem data inflammatori factor immun cell subtyp detect treatment level wbc p creatinin p p th th week signific decreas fucoidan group lung function fev fvc pr signific increas fucoidan group p regard proport immun cell level ifn cd ifn cell fucoidan group signific increas treatment period p proport cd cd cell p cd cd cell p fucoidan group signific decreas treatment period regard cytokin level interleukin il also signific reduc fucoidan group treatment period
D001249
T047
36,307,492
growth characterist cunninghamia lanceolata china chines fir cunninghamia lanceolata one southern china import nativ tree speci experienc notic climat induc chang publish paper tree growth chines fir forest china collect critic review comprehens growth data set develop site distribut e longitud n latitud altitud dataset consist entri includ mean dbh cm mean h volum biomass dri weight kg stem bark biomass branch biomass leav biomass bark biomass aboveground biomass root biomass total tree biomass relat inform ie geograph locat countri provinc studi site longitud latitud altitud slope aspect climat mean annual precipit map mean annual temperatur mat stand descript origin age canopi densiti stand densiti sampl regim plot size number investig year result show best predict height obtain use nonlinear composit model height formula see text r p equat volum dbh height r p observ suitabl model volum estim meanwhil measur variabl difficult carri volum model volum dbh dbh r p root explain greater variabl branch biomass foliag biomass equat poorest among biomass compon r estim equat deriv studi particular suitabl chines fir forest china dataset provid theoret basi predict assess potenti carbon sequestr afforest activ chines fir forest nation scale
D032486
T002
36,307,491
hifi chromosom scale diploid assembl grape rootstock r kober bb mgt cultiv grapevin common graft close relat speci cope specif biotic abiot stress condit three north american viti speci v riparia v rupestri v berlandieri main speci use breed grape rootstock report diploid chromosom scale assembl three wide use rootstock deriv speci richter r kober bb millardet et de grasset mgt draft genom three hybrid assembl use pacbio hifi sequenc averag coverag x fold use tool suit haplosync reconstruct two set nineteen chromosom scale pseudomolecul genom averag haploid genom size mbp residu haplotyp switch resolv use share haplotyp inform three refer genom repres valuabl resourc studi genet basi grape adapt biotic abiot stress design trait associ marker rootstock breed program
D032461;D027843
T026;T129;T116;T168;T002
36,307,490
high preval chronic kidney diseas relat risk factor rural area northeast thailand thailand chronic kidney diseas ckd screen report overal preval highest northeastern region studi aim find ckd preval kidney diseas improv global outcom criteria relat risk factor rural communiti popul base studi conduct rural sub district northeastern thailand data socio demograph status lifestyl under diseas blood pressur bodi mass index record blood urin analysi conduct along ultrasonographi kidney specimen collect analys repeat month factor associ ckd studi logist regress analysi total particip mean age year femal predomin complet studi preval ckd ie stage stage stage stage b stage stage hypertens diabet mellitus renal stone major under diseas particip awar ckd increas age male unemploy current smoke diabet hypertens underweight anemia hyperuricemia leukocytosi signific associ factor diseas studi reveal ckd develop signific public health problem rural northeastern thailand one everi four peopl ckd therefor earli intervent essenti proper manag prevent ckd
D051436;D006973;D003920
T047
36,307,489
proxim discrep intrins atom interact arrest gm phase inhibit cyclin bcdk infer molecular cellular biocompat limonen quest differ natur compound differ biomed applic especi treatment cancer high pace increas incid sever limonen portray one effect potenti candid center context breast cancer anticip count effect biomed agent requir detail understand molecular mechan biocompat studi elucid mechanist action limonen channel induct apoptosi control prolifer breast cancer cell possibl mechan explor experiment comput approach estim cell prolifer inhibit cell cycl phase distribut apoptosi analysi use flow cytometri western blot molecular dock result show reduc dose time depend viabil mcf cell studi suggest arrest cell cycl gm phase lead apoptosi discrep molecular activ mediat via signific alter protein express pattern anti apoptot protein like cyclin b cdk comput analysi show firm interact limonen cyclin b cdk protein influenc structur function integr indic mediat mechan studi conclud limonen suppress prolifer breast cancer cell induc gm phase arrest via deregul cyclin bcdk
D016203;D001943
T191;T126;T116
36,307,488
handed affect motor skill acquisit domin hand interlimb transfer non domin hand regardless task complex level patient undergo unilater orthoped neurolog rehabilit differ level impair right left domin hand howev handed complex motor task affect motor skill acquisit interlimb transfer remain unknown present studi particip perform finger key press numer keypad level sequenc complex hand random order furthermor also perform motor sequenc practic domin hand determin effect accuraci reaction time movement time nasa tlx end block test practic use confirm particip mental workload relat sequenc complex right left hand particip perform motor sequenc task faster rt use right hand although particip increas rt increas sequenc complex associ unrel handed motor sequenc practic produc motor skill acquisit interlimb transfer indic decreas rt howev chang independ handed higher sequenc complex still associ longer rt practic moreov right left hand particip rt increas magnitud increas sequenc complex similar behavior pattern observ mt rt overal rt result may indic left hemispher special motor sequenc task howev neuroimag studi need support find hand handed affect motor skill acquisit domin hand interlimb transfer non domin hand regardless task complex level
D007839;D009048
T033;T184;T040;T032
36,307,486
clinic patholog featur low grade epilepsi associ glioneuron tumor aim studi evalu clinicopatholog featur well surgic prognosi epilepsi associ glioneuron tumor gnt cd express braf mutat clinic data patient underw epilepsi surgeri gnt retrospect studi univari multivari analys perform evalu correl clinic patholog factor molecular marker cd express braf mutat gnt total patient gnt immunohistochem detect cd express cd posit vs negat among patient immunohistochem detect braf mutat braf posit vs negat univari analysi found tumor type p patient popul p seizur aura p drug resist epilepsi p concord ictal electroencephalogram eeg find p surgic resect extent p tumor locat p durat epilepsi p relat cd express concord ictal eeg find p age surgeri p relat braf mutat addit histori general tonic clonic seizur hr p drug resist epilepsi hr p concord interict eeg find hr p associ tumor progress free surviv pfs howev cd express braf mutat gnt associ surgic outcom seizur control tumor pfs cd express braf mutat gnt may part influenc distribut clinicopatholog featur patient epilepsi may abl predict surgic prognosi seizur outcom tumor recurr
D001932;D018302;D004827;D016543;D000069279
T033;T047;T191
36,307,484
tumour microbiom fusobacterium genom vietnames colorect cancer patient perturb gut microbiom associ colorect cancer crc colon overabund fusobacterium nucleatum shown consist marker despit signific promot crc genom studi fusobacterium limit enrol vietnames crc patient particip non cancer colorect polyp studi colon microbiom genom divers fusobacterium popul use combin rrna gene profil anaerob microbiolog whole genom analysi oral bacteria includ f nucleatum leptotrichia signific abund tumour microbiom obtain fusobacterium genom repres strain saliva tumour non tumour tissu six crc patient isol gut belong divers f nucleatum subspeci nucleatum animali vincentii polymorphum potenti new subspeci fusobacterium periodonticum fusobacterium popul within individu distinct case divers minim intra clonal variat phylogenet analys show within four individu tumour associ fusobacterium clonal isol non tumour tissu gene encod major virul factor fap radd show evid horizont gene transfer work provid framework understand genom divers fusobacterium within crc patient exploit develop crc diagnost therapeut option target oncobacterium
D064307;D015179
T001;T032;T191;T028
36,307,483
gate inject base field effect synaps transistor linear conduct updat onlin train neuromorph comput altern von neumann architectur requir synaps devic data store comput place three termin synaps devic attract neuromorph comput due high stabil control howev high nonlinear weight updat low dynam rang incompat convent cmos system report obstacl larg scale crossbar array propos cmos compat gate inject base field effect transistor employ thermion emiss enhanc linear conduct updat depend linear conduct mechan examin insert interfaci layer gate stack demonstr conduct mechan gate current measur conduct vari temperatur devic base thermion emiss achiev superior synapt characterist lead high perform artifici neural network simul mnist dataset
D013569;D016571
T170;T030
36,307,482
librari adaptor integr refer control improv accuraci reliabl nanopor sequenc librari adaptor short oligonucleotid attach rna dna sampl prepar next generat sequenc ngs adaptor also includ addit function element sampl index uniqu molecular identifi improv librari analysi describ control librari adaptor term captor measur accuraci reliabl ngs captor integr within librari prepar rna dna sampl encod inform retriev sequenc show captor measur accuraci nanopor sequenc evalu quantit perform metagenom rna sequenc improv normalis sampl captor also customis clinic diagnos correct systemat sequenc error improv diagnosi pathogen brca variant breast cancer captor simpl effect method increas accuraci reliabl ngs enabl comparison sampl reagent laboratori support use nanopor sequenc clinic diagnosi
D000081414
T063
36,307,480
nebul fusion inhibitori peptid protect cynomolgus macaqu measl virus infect measl contagi airborn viral infect lead caus child death among vaccin prevent diseas show aerosol lipopeptid fusion inhibitor deriv heptad repeat region measl virus mev fusion protein block respiratori mev infect non human primat model cynomolgus macaqu use custom design mesh nebul ensur effici aerosol deliveri peptid respiratori tract demonstr absenc advers effect lung patholog macaqu nebul peptid effici prevent mev infect result complet absenc mev rna mev infect cell mev specif humor respons treat anim strategi provid addit mean fight respiratori infect non vaccin peopl readili translat human trial present proof concept aerosol deliveri fusion inhibitori peptid protect measl airborn virus includ sar cov case high risk exposur
D000086382;D008457
T047;T067
36,307,478
evalu provinci carbon neutral capac yellow river basin use dpsir yellow river basin span nine provinc autonom region play import role china econom social develop ecolog secur howev studi integr concept carbon neutral research evalu carbon neutral develop level paper calcul comprehens evalu valu provinci carbon neutral capac comprehens evalu index yellow river basin drive forc pressur state impact respons dfpsir index system global entropi method base provinc data final result indic carbon neutral capac provinc yellow river basin state rapid develop achiev grade leap howev seven provinc carbon neutral capac level grade iii standard therebi leav scope substanti improv research identifi chang trend drive mechan carbon neutral capac yellow river basin provid theoret refer valu comprehens realize carbon neutral china
D045483;D002244
T121;T196;T070
36,307,477
crispr cas arabidopsi mutant gene arpc arpc subunit arp complex reveal differenti role complex subunit protein complex arp conserv role nucleat branch actin filament constitut seven subunit includ actin like subunit arp arp plus five subunit call arp complex compon relat actin knock plant mutant lack individu plant arp subunit typic phenotyp distort trichom alter pavement cell shape defect cell adhes knock mutant arabidopsi plant arp subunit character arabidopsi plant mutant miss arpc arpc subunit yet describ use crisprca generat knock mutant lack arpc arpc subunit confirm loss arpc subunit result typic arp mutant phenotyp howev mutant lack arpc subunit result plant surpris differ phenotyp result suggest plant arp complex function trichom shape requir arpc subunit fulli assembl complex necessari establish correct cell adhes epidermi
D051376;D017360
T123;T116;T002
36,307,476
toward engin photon two stroke rotari molecular motor ration engin photorespons materi eg light driven molecular motor challeng task use structur relat design rule prepar prototyp molecular rotari motor capabl complet entir revolut use exclus sequenti absorpt two photon ie photon two stroke motor mechan rotat characteris use combin non adiabat dynam simul transient absorpt spectroscopi measur result show rotor moieti rotat axial relat stator produc within picosecond ambient intermedi helic start structur discuss properti includ quantum effici help overcom oper limit classic overcrowd alken design
D017785;D020521
T047;T167
36,307,475
comparison quantit approach assess microgli morpholog reveal inconsist ecolog fallaci need standard microgli morpholog use measur neuroinflamm patholog reliabl infer critic microgli morpholog accur quantifi result easili interpret compar across studi laboratori process microgli morpholog quantifi key methodolog choic littl known choic may bias conclus appli five common use imagej base method quantifi microgli morpholog respons stimulus ident photomicrograph individu microgli cell isol photomicrograph allow direct comparison result generat use approach found lack compar across method analyz full photomicrograph signific discrep result among five method quantit method analyz microgli morpholog select base sever criteria combin method may give biolog accur represent microgli morpholog
D017628
T025
36,307,473
incid sever rise intraocular pressur intravitr inject aflibercept prefil syring aim analyz intraocular pressur iop chang follow differ intravitr inject ivi procedur without prefil syring pfs elabor possibl caus clinic studi laboratori assess eye patient iop prospect measur pre postop three group patient receiv ivi either ranibizumab rp aflibercept pfs ap aflibercept vial av ap empti volum ev assess use aflibercept pfs vial plunger align precis normal volum nv right indic line high volum hv drug eject wp without forc pressur np primari outcom post treatment iop type ivi pre treatment iop fix factor secondari outcom identif possibl confound factor age sex patholog presenc pseudophakia spheric error number inject iop mmhg post treatment iop rise mmhg observ case rp av ap group respect p pre treatment iop predict variabl iop rise p ev valu nvnp nvwp hvnp hvwp group l respect p observ mark although signific higher incid iop elev aflibercept pfs one possibl reason may error prone administ correct volum ap caution taken use aflibercept pfs order prevent potenti optic nerv damag case mark elev iop
D007429;D005901
T047;T042
36,307,472
copper sulfid zinc oxid hybrid nanocomposit wastewat decontamin pharmaceut pesticid work hybrid nanocomposit cus qds zno photocatalyst fabric facil microwav assist mw hydrotherm method green prepar process prepar photocatalyst pcs employ simul sunlight sl degrad ciprofloxacin ceftriaxon ibuprofen pharmaceut methylen blue dye trichlorophenoxyacet acid pesticid prepar photocatalyst character detail use sever composit optic morpholog techniqu influenc cus qds wt morpholog structur well photocatalyt degrad effici investig small displac plane cus plane zno confirm exist lattic interact impli format p n heterojunct tem xrd result demonstr cus qds establish uniform decor surfac zno nrs confirm form effici cus qds zno heterojunct nanostructur cus qds zno hybrid nanocomposit show enhanc crystallin light absorpt surfac area separ e h pair inhibit recombin interfaci heterojunct addit found wt cus qds zno foremost influenc result show improv photocatalyt activ cus qds zno hybrid nanocomposit compar bare zno nanorod impress photocatalyt perform cus zno heterostructur nanorod may attribut effici charg transfer prepar cus qds zno hybrid nanocomposit exhibit remov mb dye min min ibuprofen ciprofloxacin pharmaceut trichloro phenoxi acet acid pesticid catalyst amount gl although remov ceftriaxon pharmaceut acheiv min addit cus qds zno hybrid nanocomposit exhibit complet remov cod ibuprofen ceftriaxon pharmaceut trichloro phenoxi acet acid pesticid h select briefli cus qds zno hybrid nanocomposit consid promis photoact materi simul sunlight wastewat decontamin
D015034;D010575;D053761
T121;T197;T131;T073