PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
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stringlengths 4
64
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36,307,143
|
steril endogen panophthalm uncontrol diabet femal patient type diabet present casualti day histori red pain right eye visual acuiti va bilater right anterior uveiti note hazi fundal view discharg topic steroid mydriat drop day follow va remain unchang develop right proptosi restrict eye movement lid swell relat affer pupillari defect intraocular pressur iop mm hg admit treat intraven intravitr antibiot intraven antifung iop lower drug blood test show rais inflammatori marker hbac mmolmol admiss right eye vision deterior light percept b scan ultrasound reveal panophthalm retin abscess investig look sourc negat inflammatori marker settl despit aggress treatment panophthalm improv discharg follow consid enucl
|
D010202;D003924
|
T047
|
36,307,141
|
mri negat myeliti associ cerebr venous thrombosi covid infect transvers myeliti cerebr venous thrombosi repres describ neurolog complic coronavirus diseas woman earli present headach left side sensori symptom void difficulti patient also report dri cough fever nasal congest anosmia ageusia week present clinic examin show sensori disturb left side bodi start lower abdomen extend left leg consist transvers myeliti laboratori assess confirm previous infect coronavirus diseas exclud autoimmun entiti radiolog investig reveal left transvers sinus thrombosi spinal cord abnorm treatment start therapeut anticoagul intraven high dose steroid patient show signific improv neurolog deficit resolv month first document case imag negat myeliti associ cerebr venous thrombosi coronavirus diseas
|
D000086382;D009188;D020767;D020246
|
T047;T046;T067
|
36,307,140
|
curious case metastat parotid adenoid cystic carcinoma kidney woman present week histori non specif left side abdomin pain previous underw total parotidectomi adjuv radiotherapi left parotid adenoid cystic carcinoma year prior local recurr year investig reveal larg left side renal mass appear renal carcinoma sign metastat diseas patholog follow nephrectomi reveal metastat adenoid cystic carcinomametastat diseas recur month postrad nephrectomi contralater kidney lung refer medic oncolog managementthi case histori demonstr high aggress natur adenoid cystic carcinoma primari salivari gland origin rare metastasi kidney
|
D003528;D010307;D007680
|
T191
|
36,307,139
|
global diabet burden analysi region differ improv diabet care current evalu process burden diabet incomplet subject bias studi aim identifi region differ diabet burden univers level perspect peopl diabet
|
D000069550;D003920
|
T047;T066
|
36,307,136
|
five year symptom trajectori nondialysi depend ckd patient late stage ckd character signific symptom burden studi aim identifi subgroup within year trajectori symptom evolut patient ckd describ associ patient characterist outcom
|
D051436
|
T047
|
36,306,919
|
sodium butyr exert antioxid stress effect attenu induc cytotox pc cell alzheim diseas ad common neurodegen diseas characteris deposit amyloid plaqu neurofibrillari tangl increas number studi demonstr caus neuron damag mitochondri dysfunct herein evalu neuroprotect effect sodium butyr nab induc neurotox pc cell result reveal mm nab promot express angiotensin convert enzym brain deriv neurotroph factor exert neuroprotect effect activ g protein coupl receptor moreov nab could signific improv mitochondri dysfunct caus conclus nab protect pc cell induc cell damag highlight potenti nab ad treatment
|
D018696;D019636;D000544
|
T121;T047;T169;T048
|
36,306,819
|
revers transcriptas free detect viral rna use hemo klentaq dna polymeras covid pandem highlight demand fast reliabl detect viral rna although various method rna amplif detect propos limit includ caus revers transcript rt need overcom report direct detect specif rna convent polymeras chain reaction pcr requir prior rt step found hemo klentaq hktaq pose dna depend dna polymeras possess revers transcriptas activ provid reproduc amplif rna target effici compar common rt pcr use nasopharyng swab extract covid posit patient high reliabl sar cov detect base hktaq demonstr accur detect specif target provid nearbi primer allow determin rna solut affect multipl freez thaw cycl hktaq use elabor simplifi amplif techniqu intend analysi specif rna requir one dna polymeras
|
D000086382;D012367
|
T047;T067;T114
|
36,306,808
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develop high potent transthyretin amyloidogenesi inhibitor design synthesi evalu transthyretin amyloidosi attr group fatal diseas describ misfold amyloid deposit transthyretin ttr discov small molecul bind stabil ttr tetram prevent dissoci subsequ aggreg therapeut strategi patholog depart crystal structur ttr complex tolcapon potent binder clinic trial attr combin ration design molecular dynam md simul generat seri novel halogen kinet stabil among display one highest affin ttr describ far ttr crystal structur confirm format unpreced protein ligand contact predict md simul lead enhanc tetram stabil vitro whole serum demonstr md assist design ttr ligand constitut new avenu discov molecul like hold potenti becom high potent drug treat attr
|
D011228;D028227
|
T123;T047;T116
|
36,306,784
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epstein barr virus ghgl multipl site vulner virus neutral fusion inhibit epstein barr virus ebv near ubiquit adult ebv caus infecti mononucleosi associ b cell lymphoma epitheli cell malign multipl sclerosi ebv ghgl glycoprotein complex facilit fusion virus membran host cell target neutral antibodi examin site vulner virus neutral fusion inhibit within ebv ghgl develop panel human monoclon antibodi mab target five distinct antigen site ebv ghgl prevent infect epitheli b cell structur analys use x ray crystallographi electron microscopi reveal multipl site vulner defin antigen landscap ebv ghgl one mab provid near complet protect viremia lymphoma human mous ebv challeng model find provid structur antigen knowledg viral fusion machineri yield potenti therapeut antibodi prevent ebv diseas emphas ghgl target herpesvirus vaccin therapeut
|
D004854;D020031
|
T005;T047
|
36,306,783
|
compet ipsc deriv retina mhc mismatch transplant non human primat transplant embryonicinduc pluripot stem cell deriv retina escipsc retina restor host retin ganglion cell light respons end stage retin degener model host graft synaps format studi immunolog featur ipsc retina transplant use major histocompat complex mhc homozygot monkey ipsc retina monkey laser induc retin degener mhc match mismatch transplant mhc mismatch transplant without immun suppress show evid clinic sign reject histolog show graft matur without lymphocyt infiltr although immunolog test use peripher blood monocyt suggest subclin reject three four mhc mismatch monkey although extens photoreceptor rosett format observ histolog evalu function integr use mous model mous esc retina cbl transplant rd chhej mhc mismatch model elicit light respons host retin ganglion cell transplant less respons rd j mice cbl mhc match model result suggest reason use escipsc retina mhc mismatch transplant albeit caution
|
D057026;D012162
|
T046;T025
|
36,306,782
|
patient deriv parathyroid organoid tracer drug screen applic model parathyroid diseas character dysregul calcium homeostasi alter parathyroid hormon pth excret develop parathyroid target treatment imag tracer could benefit vitro model therefor aim establish patient deriv parathyroid organoid model repres human parathyroid tissu hyperplast parathyroid tissu dispers parathyroid organoid ptos cultur character pto deriv cell exhibit self renew sever passag indic presenc putat stem cell immunofluoresc rna sequenc confirm ptos phenocopi hyperplast parathyroid tissu exposur ptos increas calcium concentr pth lower drug result signific reduc pth excret ptos show specif bind imag tracer c methionin tc sestamibi data show function ptos resembl parathyroid pto model recapitul origin tissu gene protein express function pave way futur physiolog studi therapeut target tracer discoveri
|
D009940;D049950
|
T047;T024
|
36,306,781
|
cell autonom lipid handl defect stargardt ipsc deriv retin pigment epithelium cell stargardt retinopathi inherit form macular degener caus mutat gene abca character accumul lipid rich deposit retin pigment epithelium rpe rpe atrophi photoreceptor cell death inadequ mechanist insight pathophysiolog chang occur stargardt rpe hinder diseas treatment show abca knockout induc pluripot stem cell deriv rpe stgd irp patient stargardt differenti normal display intracellular lipid ceramid deposit reminisc diseas phenotyp stgd irp also show defect photoreceptor outer segment pos process reduc cathepsin b activ indic higher lysosom ph lipid deposit stgd irp lower increas activ abca lipid transport abca ortholog work suggest abca involv pos lipid handl rpe cell provid guidanc ongo gene therapi approach target rpe photoreceptor cell effect treatment
|
D055213;D057026
|
T023;T025
|
36,306,780
|
stabil cell cell adhes prevent symmetri break lock pluripot gastruloid embryon stem cell esc aggreg self organ embryo like structur name gastruloid recapitul axial organ post implant embryo crucial process symmetri break event lead emerg asymmetri spatial order structur homogen cell aggreg show budesonid glucocorticoid drug wide use treat asthma prevent esc aggreg break symmetri mechanist effect budesonid glucocorticoid receptor independ rna sequenc lineag fate analysi reveal budesonid counteract exit pluripot modifi express larg set gene associ cell migrat p axi format wnt signal correl reduc phenotyp molecular cell heterogen persist e cadherin cell cell interfac cell aggreg compact find reveal cell cell adhes properti control symmetri break cell fate transit gastruloid suggest potenti advers effect budesonid embryo develop
|
D053595;D004622
|
T018;T025
|
36,306,759
|
univers wrinkl support elast ring exact solvabl famili model describ wrinkl substrat support inextens elast ring compress identifi result wrinkl profil shown relat buckl state unsupport ring therefor univers close analyt express result univers shape provid includ one one relat pressur tension emerg analyt predict agre numer continu result within numer accuraci larg rang paramet valu point self contact
|
D011312
|
T067
|
36,306,739
|
reimagin antibodi depend cellular cytotox cancer potenti natur killer cell engag bi tri multispecif antibodi enabl develop target cancer immunotherapi redirect immun effector cell elimin malign transform cell antibodi allow simultan bind surfac antigen malign cell activ receptor innat immun cell natur killer nk cell macrophag neutrophil signific progress antibodi achiev particular hematolog malign nevertheless sever major challeng remain includ increas immunotherapeut efficaci greater proport patient particular harbor solid tumor overcom dose limit toxic immunogen discuss novel antibodi engin develop design maxim potenti nk cell nk cell engag mediat antibodi depend cellular cytotox adcc therebi expand armamentarium cancer immunotherapi
|
D000920;D009369
|
T191;T043
|
36,306,736
|
influenc rare copi number variat human complex trait human genom contain hundr thousand region harbor copi number variant cnv howev phenotyp effect polymorph unknown larger cnvs ascertain snp array data generat larg biobank develop comput approach leverag haplotyp share biobank cohort sensit detect cnvs appli uk biobank approach account approxim half rare gene inactiv event produc genom structur variat cnv call set enabl detail analysi associ cnvs quantit trait identifi independ associ p like causal driven cnvs putat target gene identifi near half loci enabl insight dosag sensit gene uncov sever gene trait relationship result demonstr abil haplotyp inform analysi provid insight genet basi human complex trait
|
D040641;D020412
|
T045;T032;T028
|
36,306,735
|
trem drive microglia respons amyloid via syk depend independ pathway genet studi highlight microglia pivot orchestr alzheim diseas ad microglia adher plaqu acquir transcript signatur diseas associ microglia dam larg eman trem dap receptor complex transmit intracellular signal protein tyrosin kinas syk human trem rh variant associ high ad risk fail activ microglia via syk found syk defici microglia encas plaqu acceler brain patholog behavior deficit syk defici impair pik akt gsk mtor pathway incapacit anabol support requir attain dam profil howev syk defici microglia prolifer advanc apo express prodrom stage dam pathway reli adapt dap also bind trem thus microgli respons involv non redund syk dap pathway system administr antibodi cleca receptor direct activ syk rescu microglia activ mice express trem rh allel unveil new option ad immunotherapi
|
D017628;D000544
|
T047;T025;T048
|
36,306,734
|
high throughput sequenc singl neuron project reveal spatial organ olfactori cortex sensori modal neuron connect reflect behavior relev stimulus featur spatial locat orient sound frequenc contrast prevail view olfactori cortex base reconstruct dozen neuron connect random use high throughput sequenc base neuroanatom techniqu analyz project mous olfactori bulb piriform cortex output neuron singl cell resolut surpris statist analysi much larger dataset reveal olfactori cortex connect spatial structur singl olfactori bulb neuron target particular locat along anterior posterior axi piriform cortex also project match function distinct extra piriform target moreov singl neuron target piriform locus also project match extra piriform target form triadic circuit motif thus sensori modal olfactori inform rout earli stage process function divers target coordin manner
|
D009833;D066194
|
T023
|
36,306,733
|
structur basi cas target activ target dna specif crispr associ genom editor nucleas cas determin complementar nucleotid segment guid rna howev cas bind cleav partial complementari target sequenc rais safeti concern use clinic applic report crystallograph structur cas bound bona fide target substrat reveal target bind enabl rang noncanon base pair interact within guid target heteroduplex target substrat contain singl nucleotid delet relat guid rna accommod base skip multipl noncanon base pair rather rna bulg format final pam distal mismatch result duplex unpair induc conform chang cas rec lobe perturb conform activ togeth insight provid structur rational target activ cas contribut improv ration design guid rnas target predict algorithm
|
D017394;D064113
|
T123;T040;T114
|
36,306,732
|
ad data gut feel pain sens neuron detect environment insult tissu injuri drive avoid behavior local releas neuropeptid two relat paper issu cell report gut innerv pain neuron sens bacteri presenc shape constitu gut microbiom protect excess inflamm
|
D009479;D000069196
|
T123;T007;T116;T001
|
36,306,731
|
microglia syk cell debri neurodegen diseas resid cns macrophag term microglia assum neuroprotect role engulf toxic protein aggreg cell debri issu cell two group independ show spleen tyrosin kinas syk act downstream microgli surfac receptor propag neuroprotect program vivo
|
D017628;D019636
|
T047;T025
|
36,306,730
|
peopl attract mosquito other mosquito reli sens smell find human secur blood meal transmit dead diseas bite issu cell de obalda colleagu examin mosquito bite peopl other report associ level carboxyl acid human skin odor
|
D009033
|
T204
|
36,306,729
|
et tu vibrio cholera kin cannib bacteri secret system type vi secret system molecular syring use gram negat bacteria kill heterospecif non kin nich competitor issu cell mashruwala et al show coloni pathogen vibrio cholera also exhibit tss mediat cell kill kin cell process benefit emerg resist mutant therebi increas genet divers
|
D014734;D000069376
|
T007;T116
|
36,306,721
|
conundrum diabet neuropathi past present futur diabet neuropathi dn remain arguabl preval chronic complic peopl type type diabet includ youth despit chang current standard clinic care addit emerg evid demonstr neuropathi affect larg proport peopl undiagnos diabet andor prediabet well obes summar latest epidemiolog dn recent find regard pathophysiolog diseas well current outcom measur screen diagnosi research clinic set author discuss novel perspect impact social determin health dn develop manag latest evid effect therapi includ pharmacolog nonpharmacolog therapi neuropath pain throughout public identifi knowledg gap need futur fund address gap well need advoc person care approach reduc burden dn optim qualiti life affect individu
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D003929;D003924;D009437
|
T184;T047
|
36,306,720
|
explor role drive experi self report real world aberr drive behavior signific proport global road crash attribut unsaf drive behavior current studi aim explor potenti differ drive behavior across experienc novic driver use two separ approach questionnair studi instrument vehicl studi iv analysi questionnair traffic interact within iv revel drive experi affect drive perform differ drive task factor analysi questionnair data reveal impact drive error laps violat aggress violat behavior novic experienc driver behavior model novic experienc driver encount road user determin use binari logist regress result show novic driver like engag drive violat experienc driver like engag aggress violat unauthor speed zigzag movement use mobil phone drive unauthor overtak road frequent drive violat novic driver frequent aggress violat experienc driver tempt driver creat race chase driver find may use framework facilit safer drive behavior reduc error laps violat aggress violat facilit safeti promot attitud
|
D000063;D001334
|
T056;T037;T067
|
36,306,699
|
peptid inhibitor angiotensin convert enzym base angiotensin select c termin domain renin angiotensin system ras key regul human arteri pressur sever effect modul angiotensin ii octapeptid origin action angiotensin convert enzym ace decapeptid angiotensin ace possess two activ site nace cace kinet substrat specif ace inhibitor wide use first line treatment hypertens heart relat diseas inactiv ace domain use associ serious side effect thus search domain specif ace inhibitor focus intens research angiotensin peptid also belong ras act substrat nace inhibitor cace synthet deriv ang sequenti remov n termin amino acid modifi peptid extrem find molecul improv select inhibit properti ac ang nh good ace inhibitor resist cleavag improv cace select molecular dynam simul provid model peptid select due val tyr interact ace subsit val import interact subsit sinc remov great reduc peptid enzym interact taken togeth find support ongo studi use insight bind ac ang nh develop effect cace inhibitor
|
D007703;D000803
|
T123;T129;T126;T116
|
36,306,689
|
determin eight phosphatidylethanol homologu blood revers phase liquid chromatographi tandem mass spectrometri avoid co elut phosphatidylethanol unwant phospholipid phosphatidylethanol peth specif direct alcohol biomark substanti longer half life ethanol use distinguish heavi social drink forti peth homologu detect blood heavi drinker peth predomin one sinc peth phospholipid difficult isol unwant phospholipid sampl prepar minim possibl matrix effect therefor import separ peth phospholipid lc msms analysi studi investig retent chromatograph separ eight peth homologu phospholipid background influenc chang mobil phase composit use two differ lc column acquiti beh c column mm id particl kinetex biphenyl column mm id particl find show buffer concentr aqueous part mobil phase huge effect retent peth homologu separ peth unwant phospholipid use buffer free mobil phase consist ammonia type water ph solvent methanol solvent b eight peth homologu separ earli elut lyso phospholipid later elut phospholipid two fatti chain use beh c column knowledg obtain studi great import seek develop reliabl robust bioanalyt lc msms method determin peth homologu
|
D053719;D010743
|
T063;T123;T109
|
36,306,685
|
activ cgas sting pathway ros respons nanoparticl deliv hybrid prodrug enhanc chemo immunotherapi cgas sting pathway essenti intracellular immun respons pathway attract much attent tumor immunotherapi howev low metabol stabil convent sting agonist limit clinic applic recent studi show chemotherapeut drug cisplatin camptothecin cpt activ cgas sting pathway induc immun respons dna damag nevertheless abil chemotherapeut drug activ sting weak new strategi requir improv drug deliveri effici enhanc dna damag effici activ cgas sting pathway herein develop hybrid platinum prodrug cpt pt iv trigger releas cisplatin cpt tumor cell cpt pt iv high hydrophob self assembl ros sensit polym p mpeg k dspe ros respons nanoparticl nps nps could accumul tumor site releas cisplatin cpt result dna doubl damag final activ cgas sting pathway induc dc cell matur increas tumor infiltr cd cell colorect cancer mous model studi show common dna target drug activ cgas sting pathway situ via nano deliveri system enhanc effect chemotherapi immunotherapi provid new strategi clinic antitumor therapi
|
D053758;D009369;D011355
|
T120;T191;T073
|
36,306,684
|
microfluid demonstr cluster sprout infiltr mode hypox mesenchym stem cell guid cancer cell migrat mesenchym stem cell mscs play critic role tumor metastasi howev dynam process mscs mediat cancer cell invas remain inconclus breast cancer mous model observ mscs promot lung metastasi construct microfluid base co cultur devic monitor mscs mediat cancer cell invas nutrient defici hypox microenviron biomimet microfluid devic mscs guid cancer cell migrat cluster sprout infiltr mode import hypox condit signific promot mscs migrat infiltr stage lead acceler breast cancer cell invas moreov hypoxia relat lncrna analysi show h dramat upregul respons hypox condit convers h deplet impair mscs direct breast cancer cell invas mechanist h function competit endogen rna cerna sequest mirna let releas target matrix metalloproteinas mmp intrigu aspirin dramat suppress h mmp express block mscs infiltr hypox condit result allevi breast cancer cell invas find point metastat promot role mscs tumor stroma suggest mscs might therapeut target metastat breast cancer
|
D062085;D059630
|
T123;T025;T114
|
36,306,683
|
nuclear transport stat determin matrix rigid depend activ macrophag altern activ macrophag oppos well character pro inflammatori macrophag vital regul anti inflamm wound heal tissu repair maintain tissu homeostasi although ubiquit presenc macrophag divers tissu expos differ physic environ infer distinct immun respons macrophag high phenotyp heterogen under mechan vari extracellular mechan condit alter immunolog activ remain unclear demonstr activ requir threshold mechan cue extracellular microenviron matrix rigid depend macrophag spread mediat f actin format essenti regul mechanosensit activ macrophag identifi new mechanosens function stat signal transduc activ transcript key transcript factor activ whose intranuclear transport promot rigid matrix facilit f actin format find highlight critic role mechanosensit activ macrophag long term adapt extracellular microenviron bridg nuclear mechanosens immun respons
|
D008262;D000199
|
T123;T116;T043
|
36,306,682
|
assess multi chemic exposur use human biomonitor data french esteban studi use exposur load method exposur chemic substanc common come sever sourc environment food occup often studi use substanc substanc approach although method help identifi determin exposur singl chemic accur reflect exposur multipl chemic studi use concept exposur load el evalu multi chemic exposur repres sampl general french popul el correspond number substanc metabolit measur bodi fluid defin concentr threshold el calcul adult children separ two group substanc current found domest environ group pesticid group b although el assess health impact link multi chemic exposur aid identif particular vulner popul accord prevent action specif aim subgroup could use group found multi chemic exposur general sinc adult children el greater equal substanc studi loq limit quantif consid discret threshold adult men smoker peopl work age ie peopl year old higher el group b multi chemic exposur also general sinc adult substanc studi children substanc studi mean el almost equal loq consid discret threshold adult person occup exposur pesticid dust higher el p consid discret threshold studi highlight widespread multi chemic exposur adult children franc major impact occup exposur group b tobacco smoke group el
|
D016273;D010575
|
T131;T037
|
36,306,679
|
ar p ar cross section mev determin safeti use argon deuteron beam stop materi ar p ar cross section measur averag deuteron energi mev mev mev use activ method mev deuteron beam produc lawrenc berkeley nation laboratori inch cyclotron degrad energi nickel foil front wall aluminum gas chamber reduc energi deuteron use activ sampl nat ar gas irradi gas chamber ar activ measur high puriti germanium detector cross section measur larger previous measur
|
D017357
|
T074;T073
|
36,306,653
|
assess data gather chatbot base symptom checker clinic vignett studi burden healthcar system mount continu owe popul growth age overus medic servic recent covid pandem overload also caus reduc healthcar qualiti outcom one solut gain momentum integr intellig self assess tool known symptom checker healthcar provid system best knowledg studi far investig data gather capabl tool repres crucial resourc simul doctor skill medic interview
|
D000086382
|
T047;T067
|
36,306,652
|
ambul dispatch prioritis traffic crash use machin learn natur languag approach demand emerg ambul increas therefor import ambul dispatch prioritis appropri mean accur identifi incid requir light siren l respons traffic crash difficult identifi need patient base bystand report emerg phone call traffic crash complex event often multipl patient crash vari medic need studi aim determin well text sent paramed en rout traffic crash scene emerg medic dispatch emd combin dispatch code predict need l ambul respons traffic crash
|
D000552;D004632
|
T061;T073;T093;T058;T074
|
36,306,637
|
qualiti design guid develop capillari electrophoresi method chiral puriti determin silodosin silodosin singl isom select adrenoreceptor antagonist use treatment benign prostat hyperplasia order control enantiomer puriti drug capillari electrophoresi method develop applic analysi drug substanc well pharmaceut formul method develop follow qualiti design strategi select carboxymethyl cyclodextrin suitabl chiral selector start condit scout phase two level full factori design appli identifi critic process paramet final method optim perform use face center central composit design result condit mm sodium phosphat buffer ph contain mgml car boxymethyl cyclodextrin capillari temperatur c appli voltag kv robust test employ plackett burman design reveal import care ph adjust order achiev suitabl peak shape resolut method valid accord guidelin q r intern council harmon technic requir pharmaceut human use appli analysi commerci capsul formul
|
D019075;D003505
|
T130;T059;T109
|
36,306,556
|
hydrogel patch pretreat stem cell acceler wound closur diabet rat delay wound heal diabet mellit result disord caus persist microbi infect pain poor qualiti life disord treat sever strategi use natur biomateri growth factor stem cell mold various scaffold possess potenti acceler closur impair diabet wound studi develop hydrogel patch use chitosan cs polyethylen glycol peg laden bone marrow deriv mesenchym stem cell bmscs pretreat fibroblast growth factor fgf develop hydrogel patch character scan electron microscopi fourier transform infrar ftir spectroscopi studi swell behavior growth factor fgf use modul bmsc hyperglycem environ later fgf treat bmsc embed cspeg hydrogel patch wound closur effect assess diabet rat result show cspeg hydrogel patch good biocompat possess effici bmsc recruit properti applic cspeg hydrogel patch acceler wound closur diabet rat compar control group howev use fgf pretreat bmscs lade cspeg hydrogel patch increas therapeut efficaci wound closur diabet rat studi demonstr applic hydrogel patch cspeg fgf pretreat bmscs improv diabet wound heal studi need larger anim use dress clinic trial
|
D003921;D048271
|
T121;T050;T109
|
36,306,555
|
free stand multilay film growth factor reservoir futur wound dress applic chronic skin wound place high burden patient health care system use angiogen mitogen growth factor facilit heal growth factor quick inactiv wound environ ad exogen free stand multilay film fsf fabric chitosan algin oppos polyelectrolyt altern manner use layer layer techniqu one hundr bilay form thick detach free stand film subsequ crosslink either ethyl dimethylaminopropyl carbodiimid combin n hydroxysuccinimid e fsf genipin g fsf character swell oxygen permeabl crosslink densiti show reduc swell oxygen permeabl crosslink film compar non crosslink film n fsf load fibroblast growth factor fgf film result sustain releas crosslink fsf comparison non crosslink fsf biocompat studi vitro human dermal fibroblast cultur underneath film demonstr increas cell growth cell migrat film without fgf especi g fsf load fgf great increas cell prolifer migrat vivo biocompat studi subcutan implant mice show e fsf caus inflammatori tissu respons absent case g fsf n fsf also repres biocompat film show earli degrad fsf possess antibacteri properti gram gram bacteria demonstr agar diffus disc assay summari fsf made algin chitosan crosslink genipin act reservoir sustain releas fgf possess high biocompat vitro vivo moreov g fsf promot growth migrat human dermal fibroblast antibacteri properti make interest candid bioactiv wound
|
D048271
|
T121;T109
|
36,306,546
|
enterococcus spp chicken meat collect year apart overcom multipl stress occur poultri product chain antibiot copper acid poultri meat vehicl antibiot resist bacteria gene yet divers select pressur associ mainten poultri product chain remain poor explor evalu suscept enterococcus spp chicken meat collect year apart antibiot metal acid ph peracet acid paa contemporari chicken meat sampl n batch includ pool neck skin singl carcass collect slaughterhous facil use paa disinfect march august north portug broiler rais intens farm n use cuso organ acid feed addit data compar sampl recov region sampl multidrug resist mdr isol carri enterococcus faecali enterococcus faecium enterococcus gallinarum resist tetracyclin erythromycin ampicillin quinupristin dalfopristin ciprofloxacin chloramphenicol aminoglycosid resist rate similar p sampl five antibiot decreas sampl carri vancomycin resist isol strike differ isol period similar suscept acid ph minimum growth ph minimum surviv ph paa mic mglmbc mgl concentr use slaughterhous copper toler gene tcrb andor cueo respect detect sampl tcrb gene detect e faecali mic cuso mm genom compar intern one chicken origin patric databas reveal polyclon popul plasmid chromosom locat tcrb tcrb plasmid share divers genet modul includ multipl antimicrobi resist gene eg tetracyclin chloramphenicol macrolid lincosamid streptogramin b mls b aminoglycosid bacitracin coccidiostat chromosom tcrb gene co locat close mera mercuri gene chicken meat remain import vehicl mdr enterococcus spp abl surviv divers stress eg copper acid potenti contribut bacteria mainten flux among anim environ human
|
D002645;D016984
|
T007;T012
|
36,306,545
|
effect food process factor growth kinet aeromona strain isol readi eat seafood aeromona ubiquit aquat bacteria frequent isol seafood grow awar aeromona foodborn pathogen particular connect consumpt readi eat rte seafood aim studi investig effect food process factor growth kinet eight aeromona strain repres seven speci isol rte seafood effect low temperatur c combin differ nacl concentr two purifi condens smoke pcss red arrow smokez vtabb jjt differ concentr studi trypton soy broth tsb food process applic pcs consid healthier tradit smoke growth kinet paramet strain estim use primari predict model result show addit nacl refriger temperatur c suffici inhibit growth media bestiarum piscicola salmonicida higher nacl concentr c suppress growth hand result demonstr antimicrobi potenti use pcs maxim allow concentr aeromona pcs concentr phenol content import factor influenc growth kinet paramet aeromona moreov growth kinet three aeromona strain studi commerci produc vacuum pack fresh cold smoke salmon store c day respect result demonstr vacuum pack combin cold storag c insuffici inhibit growth aeromona fresh salmon growth inhibit minim salt cold smoke salmon salt content studi impli mild food process factor appli product rte seafood might guarante total inhibit aeromona even though studi evalu antimicrobi potenti pcss actual seafood matrix necessari present studi suggest pcs technolog might promis approach prevent potenti growth aeromona
|
D000333;D008089
|
T007
|
36,306,534
|
genet encod light rna amplifi dissect microrna activ live cell live cell dissect microrna activ crucial basic translat medicin current hybrid base strategi may fail dissect surround depend activ develop genet encod mirna induc light rna amp lifier ilamp enabl fast activ signal amplifi fluorogen imag mirna activ live cell ilamp respond mirna target mode activ upon cleavag light rna aptam restor fluoresc rapid upon cleavag rna induc silenc complex demonstr ilamp afford substanti signal amplif fold high specif singl nucleotid discrimin mirna mediat cyclic cleavag combin mango rna aptam refer modul pseudoknot termin stabil ilamp shown quantit ratiometr imag dynam monitor mirna activ exogen stimul ilamp featur modular plug play design readili adapt detect mirna highlight potenti track cell differenti screen mirna therapeut
|
D035683;D052157
|
T123;T114
|
36,306,527
|
plasmon generat solvat electron chemic transform method generat solvat electronsfre electron solutionhav focus primarili alkali metal ionize high energi electron photon report generat solvat electron excit plasmon reson al nanocryst suspend solut visibl light two chemic reaction perform radic addit reaction spin trap methyl nitrosopropan model cyclize reaction radic clock bromohex ene quantum effici least plasmon absorb photon solvat electron generat infer measur radic clock reaction concentr studi demonstr simpl way generat solvat electron drive reduct organ chemic reaction quantifi control manner
|
D004583;D008027
|
T081;T196;T070
|
36,306,517
|
nation control laboratori assess qualiti rituximab biosimilar india past year mani rituximab rtx biosimilar launch india biosimilar product similar term qualiti safeti efficaci innov product expect offer improv afford less clinic examin signific sourc reduct cost develop biosimilar howev clinic relief predic assumpt analyt similar biosimilar innov product therefor role nation control laboratori becom import ensur qualiti drug carri analyt character point drug product releas level refer nation regulatori author qualiti evalu assess similar innov biosimilar differ physicochem biolog qualiti attribut assess multitud state art analysi n rtx biosimilar market india reveal impur profil biosimilar measur charg variant analysi cation exchang chromatographi high perform liquid chromatographi hplc capillari zone electrophoresi capillari isoelectr focus aggreg profil size exclus chromatographi hplc fragment analysi capillari electrophoresi sodium dodecyl sulfat found signific vari compar innov product signific variat acid variant p basic variant p isoelectr point valu p aggreg p fragment p biosimilar found innov product howev differ affect biolog activ cell base potenc analysi complement depend cytotox cdc assay p antibodi depend cell mediat cytotox adcc p bind assay flow cytomet fluoresc activ cell sort p biosimilar compar innov product
|
D059451
|
T121
|
36,306,515
|
har antibodi polyspecif cancer immunotherapi target divers glycan repertoir express tumor cell consid viabl therapeut strategi deal tumor cell heterogen inher polyspecif natur glycan reactiv antibodi purport protect thwart infect cancer immunotherapi tumor associ carbohydr antigen taca relat pathogen glycan nascent natur antibodi exist igm respons elicit captur polyspecif natur anticarbohydr respons focus ration design carbohydr mimet peptid cmps cross reactiv taca reactiv antibodi particular focus develop cmps display reactiv gd lewi ley reactiv monoclon antibodi would serv templat pan immunogen induc biosimilar polyreact antibodi design reli structur analys cmp enhanc bind templat use molecular model glycan reactiv pattern affin cmp purifi human antibodi refin specif profil comparison immun respons cmp clinic trial studi defin molecular characterist mimicri consid polyspecif ley gd reactiv antibodi bind lacto ceramid core gal glc cer bind minimum build block capit cancer therapi diagnost illustr new approach design cancer vaccin take advantag latent polyspecif antibodi relev natur antibodi antigen discoveri design
|
D019496;D009369
|
T129;T121;T191;T116
|
36,306,514
|
klmab anti human klrg monoclon antibodi immunocytochemistri immun checkpoint molecul receiv attent target cancer immunotherapi killer cell lectin like receptor subfamili g member klrg one immun checkpoint molecul express cd cd natur killer nk cell klrg exhibit antivir antitumor immun express nk cell upregul viral infecti diseas tumor thus monoclon antibodi mab klrg would use tool diagnosi immunotherapi viral infecti diseas cancer develop anti human klrg hklrg mab clone klmab mous igg kappa cell base immun screen method also demonstr klmab recogn exogen endogen hklrg flow cytometri studi first show klmab recombin mab recklmab bound exogen hklrg overexpress chines hamster ovari cho k cell parent cho k cell immunocytochemistri next show mab detect endogen hklrg express human nk cell result demonstr klmab recklmab avail immunocytochemistri
|
D000082102;D000911
|
T129;T116
|
36,306,512
|
valu serum sri box transcript factor level combin magnet reson imag diagnosi endometri carcinoma object investig role sri box transcript factor sox endometri carcinoma diagnost valu serum sox level combin magnet reson imag mri method present prospect observ studi includ case endometri carcinoma patient receiv measur serum sox mri detect two week prior surgeri patient demograph clinic data includ age bmi cancer stage tumor differenti invas lymph node metastasi collect patient follow year follow surgeri result deceas patient show signific higher ratio figo stage iii iv tumor low tumor differenti myometri invas depth cervic invas lymph node metastas distant metastasi signific lower surviv patient deceas patient serum level sox signific higher endometri carcinoma patient compar healthi control remark higher deceas patient patient elev sox level also higher rate figo stage iii iv higher rate myometri invas depth higher rate low tumor differenti elev sox level correl higher rate lymph node metastas distant metastas year mortal serum sox level combin mri potenti improv diagnosi myometri invas lymph node metastasi endometri carcinoma conclus elev serum sox level associ poor prognos patient endometri carcinoma serum sox level combin mri could use diagnosi prognosi endometri carcinoma
|
D016889
|
T191
|
36,306,511
|
associ ptpn ct variant vascul meta analysi updat trial sequenti analysi object present studi design determin whether protein tyrosin phosphatas non receptor ptpn ct variant associ suscept vascul method meta analysi conduct evalu associ ptpn ct variant vascul trial sequenti analysi perform evalu robust meta analysi result total studi includ meta analysi reveal high signific associ ptpn allel vascul multipl type odd ratio confid interv ci p meta analysi vascul type show associ allel risk giant cell arter gca antineutrophil cytoplasm antibodi associ vascul aav ci p ci p meta analysi also indic associ allel takayasu arter allel behcet diseas henoch schnlein purpura tsa indic observ associ conclus exist evid conclus meta analysi confirm ptpn ct variant associ suscept gca aav
|
D020022;D014657
|
T047;T032
|
36,306,499
|
evalu clinic util bone metastas ensembl tree surviv decis support platform bmet dsp case base pilot assess bone metastas ensembl tree surviv decis support platform bmet dsp provid patient specif surviv predict evid base recommend guid multidisciplinari manag symptomat bone metastas assess clinic util bmet dsp pilot prepost design simul clinic environ
|
D001859;D018787
|
T191;T091
|
36,306,498
|
aya care plan initi evalu web base psychosoci intervent adolesc young adult aya cancer fit neat pediatr older adult oncolog care set recent effort led develop psychosoci intervent aya studi show aya demonstr low level engag psychosoci servic aya care plan one web base tool provid person psychosoci resourc address unmet need aya activ treatment post treatment survivorship current studi aim assess usabl util aya care plan identifi opportun improv
|
D000083626;D009369
|
T061;T191
|
36,306,475
|
structur dynam thermal stress monoclon antibodi character temperatur depend hd exchang mass spectrometri differenti scan calorimetri dsc standard tool probe resili monoclon antibodi mab protein therapeut thermal degrad unfortun dsc usual provid insight global unfold although sequenti step sometim discern multidomain protein temperatur depend hydrogendeuterium exchang hdx mass spectrometri ms potenti probe heat induc event much greater level detail recent propos strategi deconvolut temperatur depend hdx data contribut local dynam global unfoldingrefold well chemic label howev strategi valid small protein tajoddin n n konermann l anal chem current work explor applic hdx framework nist refer mab nistmab larg multidomain protein prone aggreg three melt point use global fit abl model hdx profil across nistmab sequenc zero c time point min uncov enthalp entrop contribut local fluctuat govern conform dynam low temperatur ch ch domain found increas affect global unfoldingrefold vicin melt point although transient unfold protein display signific residu protect global dynam involv deuter fab domain highest melt point instead global fab unfold follow immedi irrevers aggreg result reveal thermodynam hdx ms strategi appli work well suit probe spatial resolv dynam thermal stress larg protein mab complement data obtain dsc
|
D000911;D000080307
|
T129;T059;T116
|
36,306,471
|
block non enzymat function protac mediat target protein degrad non enzymat function target protein play key role regul various cell signal pathway close relat numer human diseas howev tradit small molecul inhibitor general target catalyt function domain direct work inhibit enzymat function target protein without affect non enzymat function recent emerg proteolysi target chimera protac technolog advantag simultan regul enzymat non enzymat function target protein thus provid potenti strategi make defici inhibitor explor new therapeut profil target degrad perspect aim specif summar analyz recent progress block non enzymat function target protein protac mediat degrad highlight repres case studi discuss pharmacolog featur origin inhibit non enzymat function
|
D011506;D015398
|
T123;T116;T044;T043
|
36,306,467
|
systemat review key concept health profession exponenti growth current avail evid made necessari collect filter critic apprais synthes biomed inform keep date sens systemat review help tool reliabl sourc assist evid base decis make systemat review defin secondari research synthes evid focus specif question base structur methodolog make possibl identifi select critic apprais summar find relev studi systemat review sever potenti advantag minim bias obtain accur result reliabl evid present systemat review determin amongst factor qualiti methodolog includ studi conduct systemat review seri step must follow formul research question use particip intervent comparison outcom pico format exhaust literatur search select relev studi critic apprais data obtain includ studi synthesi result often use statist method meta analysi final estim certainti evid outcom methodolog note defin basic concept systemat review method limit
|
D006282
|
T097
|
36,306,448
|
scalabl uniform length tunabl biodegrad block copolym nanofib polycarbon core via live polymer induc crystal driven self assembl uniform block copolym bcp nanofib prepar seed growth approach term live crystal driven self assembl cdsa offer promis potenti various applic due anisotropi length tunabl variabl core coron chemistri howev procedur consist multi step process involv independ bcp synthesi self assembl step latter perform low solut concentr wt hinder scale demonstr use one pot bcp synthesi self assembl process polymer induc cdsa pi cdsa access length dispers nanofib biodegrad crystallin poli fluorenetrimethylenecarbon pftmc core hydrophil poli ethylen glycol peg corona deriv peg b pftmc concentr wt time higher previous report furthermor live pi cdsa could use access scalabl low dispers length tunabl peg b pftmc nanofib concentr wt provid first exampl live pi cdsa involv organ biodegrad bcp util conveni implement bcp synthesi protocol involv live anion polymer signific sampl low dispers nanofib control length nm l w l n prepar allow upscal access well defin biodegrad nanofib use length scale applic nanomedicin interest detail studi reveal key role pftmc homopolym impur bcp prepar situ format nanofib reaction condit use
|
D057139
|
T073
|
36,306,444
|
individu memori cope covid lockdown famili member experi understand psycholog behavior reaction emerg infecti diseas crucial manag outbreak studi sought explain famili member experi individu memori cope covid lockdown
|
D000086382
|
T047;T067
|
36,306,427
|
melissa officinali l sprout suppressor solanum tuberosum l altern synthet pesticid goal research screen plant essenti oil eo sprout inhibitor suppressor potato solanum tuberosum l three control environ experi conduct screen eo sever pure compound sprout inhibitor eo appli use wick method potato cv gala l plastic contain result indic melissa officinali l eo inhibit sprout coriandrum sativum l seed oil eo blend lavandula angustifolia mill salvia sclarea l suppress sprout eo interest analyz use gas chromatographi coupl mass spectrometri gc ms andor flame ionize detector gc fid detail chemic profil provid officinali eo fraction seven fraction test minitub identifi two fraction f suppress potato sprout better whole oil gc ms fid analys officinali eo fraction identifi myrcen z ocimen e ocimen tran caryophyllen humulen main constitu main constitu fraction f terpineol citronellol geraniol pure isol compound togeth major compound officinali eo citral test sprout suppress three potato cultivar ranger russet terra rosa dakota trailblaz reveal citronellol reduc sprout length number sprout three cultivar citral terpineol reduc sprout length number sprout ranger russet relat two control three cultivar myrcen stimul effect number sprout cv terra rosa howev none pure compound suppress sprout complet compar eo officinali
|
D031334;D011198;D010575;D009822
|
T168;T131;T002;T109
|
36,306,425
|
emerg medicin switzerland analysi physician workforc gender equal academ global emerg medicin continu evolv numer countri societi colleg help develop specialti profession academ level howev countri includ switzerland emerg medicin fulli recognis specialti histor gender gap
|
D004635;D010820
|
T091;T097
|
36,306,420
|
microscal diffusiophoresi protein live system character spatial high inhomogen natur suscept modifi fundament behavior biomolecular speci includ protein underpin biolog function cell spatial gradient chemic potenti known lead strong transport effect colloid particl effect molecular scale speci protein remain larg unexplor improv exist diffusiophoresi microfluid techniqu measur protein diffusiophoresi real space measur protein made possibl two amelior first label free microscop use suppress label interfer second improv numer method develop meet particular challeng pose small molecul demonstr individu protein undergo strong diffusiophoret motion salt gradient manner suffici overcom diffus lead dramat chang spatial organ scale cell moreov demonstr phenomenon use control motion protein microfluid devic result open path toward physic understand role gradient live system spatial organ macromolecul highlight novel rout toward protein sort applic devic
|
D012965
|
T121;T196;T130;T197
|
36,306,412
|
use delphi process updat nisong child behavior rate form nisong child behavior rate form ncbrf develop specif screen psychopatholog problem behavior children adolesc idd studi aim updat ncbrf diagnost statist manual mental disord th edit dsm screen preval psychopatholog affect children adolesc idd author align exist item fit within dsm framework use delphi method panel expert idd evalu ncbrf item revis process includ delet revis exist item formul new item obtain final item pool three iter delphi process result item pool describ articl
|
D002653;D000066553
|
T033;T048
|
36,306,411
|
mental state languag develop children syndrom versus typic develop studi compar mental state languag talk emot thought intent etc use year old children syndrom ds younger typic develop td comparison group match nonverb cognit aim determin whether mental state languag use delay ds relat development expect differ group associ mental state languag development factor emot knowledg express languag rate mental state languag use signific lower group ds number differ mental state term signific differ nuanc pattern similar differ emerg group regard associ mental state languag development factor
|
D004314
|
T047
|
36,306,410
|
examin phenotyp differ gaze avoid autism spectrum disord fragil x syndrom examin potenti phenotyp differ eye gaze avoid exhibit boy autism spectrum disord asd boy fragil x syndrom fxs studi eye contact avoid scale eca administ caregiv boy age year fxs n asd n mix development disabl mdd n studi subset boy fxs n boy asd n receiv brief behavior treatment probe improv eye contact result show boy fxs obtain signific higher score eca compar boy asd mdd exposur brief behavior treatment probe result signific decreas score boy fxs boy asd
|
D005600;D000067877
|
T047;T048
|
36,306,409
|
public stigmat peopl intellectu disabl covid pandem studi aim examin level discrimin peopl intellectu disabl covid assess stereotyp level familiar peopl intellectu disabl person experi covid potenti correl cross section studi conduct use larg sampl dutch popul n salient stereotyp factor peopl intellectu disabl friend need help give nuisanc respond unfamiliar peopl intellectu disabl real life demonstr higher level discrimin perceiv nuisanc less need help comparison familiar peopl intellectu disabl judg ambival set stereotyp covid pandem line pre covid find seem fair persist robust press need rais awar stereotyp toward discrimin peopl intellectu disabl via advocaci educ facilit posit encount
|
D008607;D000086382
|
T047;T067;T048
|
36,306,408
|
nih toolbox cognit batteri feasibl individu william syndrom nih toolbox cognit batteri nihtb cb develop epidemiolog longitudin studi across wide age span tool may use intervent trial condit character intellectu disabl id william syndrom ws three nihtb cb task includ two execut function flanker dimension chang card sort one episod memori pictur sequenc memori task given individu ws age evalu feasibl ie proport valid administr popul find indic nihtb cb test show good feasibl flanker dccs age correct score negat correl age show floor effect indic score may use quantifi perform nihtb cb test id
|
D018980
|
T047
|
36,306,373
|
coisol peptid pair peptid identif msms base quantif stabl isotop label amino acid cell cultur silac base metabol label wide adopt proteom approach enabl quantit comparison among varieti experiment condit despit quantit capac silac experi analyz data depend acquisit dda fulli leverag peptid pair inform identif suffer undersampl compar label free proteom experi herein develop dda strategi coisol fragment silac peptid pair use ion relat quantif facilit analysi type data adapt comet sequenc databas search engin make use silac peptid pair fragment develop tool annot quantifi msms spectra coisol silac pair peptid pair coisol approach general improv expect score compar tradit dda approach fragment ion quantif perform similar well precursor quantif ms achiev quantif last method enabl reliabl msms quantif silac proteom mixtur overlap isotop distribut studi show feasibl coisol approach coupl approach intellig acquisit strategi potenti improv silac peptid sampl quantif
|
D040901;D053719
|
T063;T091
|
36,306,372
|
first class dual mechan ferroptosi hdac inhibitor hybrid hdac inhibitor attract class cytotox agent design hybrid molecul sever hdac hybrid emerg year none combin hdac inhibit ferroptosi combin extens studi lead enhanc cytotox attenu neuron toxic combin pharmacophor saha cetzol molecul design first class dual mechan hybrid molecul induc ferroptosi inhibit hdac protein involv mechan cytotox confirm seri biolog assay cytotox effect evalu seri cancer neuron cell line analogu hy demonstr best cytotox profil gi valu low nm although increas activ hybrid combin modest cellular system potenti advantag homogen spatiotempor distribut vivo system
|
D000079403;D000970
|
T121;T109;T043
|
36,306,370
|
long live plasma cell accumul bone marrow constant rate earli immun respons vaccin work larg generat long live plasma cell llpcs knowledg cell recruit spars although clear llpcs preferenti origin germin center gcs reloc surviv nich bone marrow persist decad issu time llpc recruit basi retent remain uncertain use genet timestamp system mice show persist pcs accru bone marrow approxim constant rate one cell per hour period span sever week singl immun model antigen affin base select evid persist pcs reflect relat dynam rather absolut affin threshold evidenc chang pattern v h gene somat mutat convey increas affin antigen conclud life span persist antigen specif pcs part intrins preprogram vari final number relat durat respons predict way impli modul vaccin extend durat gc reaction enhanc antibodi mediat protect immun
|
D010950;D001853
|
T023;T025;T024
|
36,306,369
|
staphylococcus aureus skin colon promot sle like autoimmun inflamm via neutrophil activ il il axi system lupus erythematosus sle autoimmun diseas character inflamm various organ skin kidney bone brain presenc autoantibodi although caus sle complet understood environment factor genet suscept hormon factor environment factor thought play essenti role pathogenesi sle among environment factor microbiota link develop differ autoimmun diseas microbiota nasal caviti gut involv sle develop influenc skin microbiota still unclear demonstr epitheli cell specif ib defici nfkbiz k mice show spontan skin inflamm increas abund staphylococcus aureus skin aureus epicutan appli nfkbiz k mice nfkbiz k mice develop sle associ autoantibodi anti dsdna antibodi anti sm antibodi glomerulonephr igg deposit epicutan aureus applic signific increas staphylococc colon skin nfkbiz k mice reduc express sever antimicrobi peptid skin staphylococc skin colon promot caspas mediat keratinocyt apoptosi neutrophil activ induc interleukin il il immun respons activ dendrit cell cell furthermor subcutan administr anti il p anti il antibodi allevi system autoimmun respons togeth find underscor epitheli immun cross talk disturb caus skin dysbiosi essenti mediat induc autoimmun diseas
|
D008180;D013203
|
T047
|
36,306,367
|
metabol synergi camelina reproduct tissu seed develop photosynthesi fruit well document contribut seed develop yield remain larg unquantifi oilse pod green elev direct access sunlight c label planta intact pod label system uniqu multi tissu comprehens flux model mechanist describ pod assimil one half seed carbon proxim photosynthesi camelina sativa captur integr tissu metabol studi reveal contribut plant architectur beyond leav enabl seed fill maxim number viabl seed latent capac pod wall absenc leav contribut approxim seed biomass support greater seed sink capac higher theoret yield suggest opportun crop product gain
|
D019607
|
T002
|
36,306,365
|
identif character circul immun complex iga nephropathi under patholog immunoglobulin iga nephropathi igan common glomerulonephr worldwid driven deposit immun complex contain galactos defici iga tn iga glomerular mesangium report novel anti tn circul immun complex anti tn cic contain predomin igm repres larg macromolecular complex megadalton sever megadalton size togeth tn iga igg complex signific elev sera patient igan contain higher level complement c compar healthi individu anti tn cic bioactiv induc specif prolifer human renal mesangi cell found anti tn cic dissoci small glycomimet compound mimic tn antigen tn iga releas iga anti tn cic glycomimet compound also signific inhibit prolif activ anti tn cic patient igan find could enhanc diagnosi igan treatment specif drug treatment unavail
|
D005922
|
T047
|
36,306,364
|
peptid dna origami cryoprotect cell preserv cryopreserv cell essenti conserv cold chain bioproduct cell base medicin demonstr self assembl dna origami nanostructur substanti abil protect cell undergo freez thaw cycl therebi use cryoprotect agent nanoscal morpholog ice philic tailor particular singl layer dna origami nanopatch function antifreez threonin peptid enabl viabil hsc cell reach month cryopreserv surpass dimethyl sulfoxid produc viabil also exhibit minim depend cryopreserv period freez condit attribut outcom fact peptid function dna nanopatch exert multisit action retard ice growth intra extracellular region protect cell membran cryopreserv discoveri expect deepen fundament understand cell surviv freez environ affect current cryopreserv technolog
|
D007053;D003451
|
T039;T121;T197
|
36,306,362
|
atr mediat dna damag respons underli aberr b cell activ system lupus erythematosus b cell orchestr autoimmun respons patient system lupus erythematosus sle broad base b cell direct therapi show modest efficaci blunt humor immun respons vaccin induc immunosuppress develop effect therapi target pathogen clone current unmet need demonstr enhanc activ atrchk pathway dna damag respons ddr b cell patient activ sle diseas treatment b cell type ifn key driver immun sle induc express atr via bind interferon regulatori factor gene promot pharmacolog target atr b cell via specif inhibitor attenu immunogen profil includ proinflammatori cytokin secret plasmablast format antibodi product togeth find identifi atr mediat ddr axi orchestr type ifn mediat b cell respons sle potenti novel therapeut target
|
D008180
|
T047
|
36,306,357
|
pabpn function hub assembl nuclear poli domain essenti mous oocyt develop grow oocyt store larg amount matern mrna support subsequ matern zygot transit process present clear grow oocyt store process newli transcrib mrna physiolog condit studi report non membran bound compart nuclear poli domain npad hub newli transcrib mrna develop mous oocyt rna bind protein pabpn promot format npad n termin disord domain rna recogn motif mean liquid phase separ pabpn null grow oocyt form npad normal vivo defect stabil oocyt grow relat transcript format long untransl region isoform transcript ultim pabpnflfl gdf cre mice complet steril primari ovarian insuffici result demonstr npad form phase separ properti pabpn mrna hub newli transcrib mrna essenti develop oocyt femal reproduct
|
D002467;D011061
|
T026;T114
|
36,306,355
|
satellit dna array barcod chromosom regul totipot via zfp mammalian genom battleground genet conflict repetit element krab zinc finger protein kzfps ask whether kzfps regul cell fate use zfp target satellit dna array zpar zpar coat megabas region chromosom encompass gene encod zscan master transcript factor totipot deplet zfp mous embryon stem cell mesc caus transit cell c like state wherebi zpar array switch pois activ enhanc state accompani global eros heterochromatin roadblock link decreas setdb stabil event result transcript activ line element impair differenti summari zfp trim partner close chromatin across zscan promot exit totipot propos satellit dnas may control development fate transit barcod switch master transcript factor gene
|
D004276;D012097
|
T123;T116;T114
|
36,306,352
|
intermedi cell vitro cellular reprogram vivo tissu regener requir desmoplakin amphibian fish show consider regener potenti via dedifferenti somat cell blastem cell term dedifferenti vitro cellular reprogram propos share common process vivo tissu regener although detail elus identifi cytoskelet linker protein desmoplakin dsp common factor mediat reprogram regener analysi reveal dsp express elev distinct intermedi cell vitro reprogram knockdown dsp imped vitro reprogram induc pluripot stem cell induc neural stemprogenitor cell well vivo regener zebrafish fin notabl reduc dsp express impair format intermedi cell cellular reprogram tissu regener find suggest dsp mediat evolutionari link cellular reprogram mammal tissu regener lower vertebr intermedi cell may provid altern approach mammalian regen therapi
|
D057026;D058953
|
T025
|
36,306,345
|
generat c label inositol inositol phosphat stabl isotop label cell cultur quantit metabolom inositol inositol phosphat ipx central metabolit accur quantit analysi complex biolog sampl challeng due lengthi sampl prepar procedur sampl loss strong adsorpt surfac unpredict matrix effect current u c inositol u c ipx avail commerci sourc studi develop method capabl generat u c inositol u c ipx inositol independ cell line ls cultur inositol free medium supplement u c glucos inositol contamin fbs observ critic paramet label effici le balanc cell growth le achiev adopt two step label strategi first step le could obtain normal cell growth long term cell cultur second step ultra label medium improv le short durat harvest generat u canalog high isotop puriti util intern standard spike sampl prepar biolog applic u canalog effect compens sampl loss sampl prepar well matrix effect electrospray ionize exemplari pharmacolog studi conduct phospholipas c inhibitor activ document great util prepar stabl isotop label intern standard elucid plc depend ip code u cipx use intern standard generat quantit profil ipx hela cell sampl treatment plc inhibitor activ establish method generat u canalog cost effect robust reproduc facilit quantit studi inositol ipx biolog scenario
|
D007295;D055432
|
T091;T109
|
36,306,331
|
electr signal cochlear effer driven intrins neuron oscil effer neuron believ play essenti role maintain auditori function later olivocochlear loc neuron project brainstem inner ear releas multipl transmitt includ peptid catecholamin acetylcholin numer yet least understood element effer control cochlea use vitro calcium imag patch clamp record found loc neuron juvenil young adult mice exhibit extrem slow wave activ hz second long burst na spike driven intrins oscil depend l type ca channel observ prehear mice suggest age depend mechan under intrins oscil use optogenet approach identifi ascend stellat cell cochlear nucleus descend auditori cortex sourc synapt excit well synapt receptor use excit addit identifi potent inhibit origin glycinerg medial nucleus trapezoid bodi mntb conduct clamp experi reveal unusu mechan electr signal loc neuron synapt excit inhibit serv switch intrins generat spike burst mechan allow prolong period activ silenc control brief synapt event protract burst action potenti may essenti effect exocytosi divers transmitt releas loc fiber cochlea
|
D017626;D065833
|
T023
|
36,306,330
|
chart c c coupl pathway electrochem co reduct cu use embed correl wavefunct theori electrochem co reduct reaction co rr power excess zero carbon emiss electr produc especi multicarbon c product could contribut carbon neutral carbon negat economi foundat ration design effici select co rr electrocatalyst mechanist analysi best metal catalyst thus far identifi name copper cu via quantum mechan comput complement experi appli embed correl wavefunct ecw theori region correct electron exchang correl error densiti function theori dft approxim examin multipl c c coupl step involv adsorb co co hydrogen deriv ubiquit facet cu predict two adsorb hydrogen co speci either coh cho necessari precursor c c bond format three kinet feasibl pathway involv speci yield three possibl product coh cho coh coh och och kinet favor path form coh cho contrast standard dft approxim arriv qualit differ conclus name co coh prevail surfac c c coupl path produc coh coh co co prefer first product work demonstr import appli qualit quantit accur quantum mechan method simul electrochemistri order ultim shed light way enhanc select toward c product format via co rr electrocatalyst
|
D002245;D003300
|
T123;T197;T121;T196
|
36,306,329
|
netfact integr intervent individu collect level treat communiti affect organ violenc war crise affect mental health social attitud cultur norm exacerb state long term insecur decad arm conflict democrat republ congo one exampl violenc becom normal civilian set studi test effect netfact health system integr model evid base individu trauma treatment narrat exposur therapi net trauma inform communiti base intervent netfact alongsid chang mental health outcom posttraumat stress disord depress social disapprov shame also investig chang attitud includ rape myth accept stigmat survivor sexual violenc skeptic reintegr former combat test whether addit communiti intervent superior individu net alon implement random control design six villag interview sampl communiti member result demonstr netfact health system comparison net alon effect reduc rape myth accept ongo victim perpetr communiti member netfact group also present less stigmat attitud survivor sexual violenc skeptic reintegr former combat declin group netfact appear increas motiv engag individu treatment synerg heal effect individu collect trauma exposur netfact health system appear effect scalabl approach correct degrad ignomini norm restor function mental health postconflict communiti
|
D011902;D012742;D013313
|
T037;T054;T048
|
36,306,328
|
observ mani research use data hypothesi reveal hidden univers uncertainti studi explor research analyt choic affect reliabl scientif find discuss reliabl problem scienc focus systemat bias broaden len emphas idiosyncrasi conscious unconsci decis research make data analysi coordin research research team observ research decis use data independ test promin social scienc hypothesi greater immigr reduc support social polici among public typic case social scienc research research team report wide diverg numer find substant conclus despit ident start condit research expertis prior belief expect bare predict wide variat research outcom total varianc numer result remain unexplain even qualit code identifi decis team workflow reveal univers uncertainti remain hidden consid singl studi isol idiosyncrat natur research result conclus vari previous underappreci explan mani scientif hypothes remain contest result call greater epistem humil clariti report scientif find
|
D012108;D000078332
|
T097;T057
|
36,306,327
|
small molecul promot optic nerv regener restor target specif neural activ visual function axon regener energi demand process requir activ mitochondri transport contrast central nervous system cns axon mitochondri transport regener axon peripher nervous system pns increas within hour sustain week injuri yet littl known target mitochondria nervous system repair report induct sustain axon regener neural activ superior colliculus sc visual function recoveri optic nerv crush onc small molecul promot mitochondri fusion transport demonstr enhanc mitochondri dynam cultur neuron acceler vivo axon regener pns ex vivo time laps imag kymograph analysi show great increas mitochondri length axon mitochondri motil transport veloc peripher axon sciatic nerv follow onc increas number axon regener optic chiasm multipl subcort area promot recoveri local field potenti sc optogenet stimul retin ganglion cell result complet recoveri pupillari light reflex restor respons loom visual stimuli detect increas gene express mitochondri fusion protein major axon transport machineri pns cns neuron without induc inflammatori respons knockdown two key mitochondri gene opa mfn abolish growth promot effect onc suggest maintain high dynam mitochondri popul axon requir success cns axon regener
|
D001369;D020221
|
T026;T037
|
36,306,326
|
activ prefront periaqueduct gray circuit overcom behavior endocrin featur passiv cope stress respons question brain link behavior biolog featur defens respons remain elus import problem underscor observ behavior passiv stress cope associ elev glucocorticoid hormon may carri risk suscept host stress relat diseas past work implic medial prefront cortex mpfc top regul stress relat behavior howev unknown whether chang capac buffer longer last biolog consequ associ avers experi use shock probe defens buri test rat naturalist measur behavior endocrin featur cope observ activ behavior compon stress cope associ increas activ along circuit involv caudal mpfc midbrain dorsolater periaqueduct gray pag optogenet manipul caudal mpfc dorsolater pag pathway bidirect modul activ escap defens buri behavior distinct rostral mpfc ventrolater pag circuit instead limit passiv immobl behavior strike condit bias rat toward passiv cope respons set includ exagger stress hormon output increas immobl excit caudal mpfc dorsolater pag project signific attenu featur result lend insight brain coordin respons featur overcom passiv cope may import understand activ neural system promot stress resili
|
D010487;D000223
|
T055;T023
|
36,306,325
|
genom wide detect human variant disrupt intron branchpoint pre messeng rna splice initi recognit singl nucleotid intron branchpoint bp within bp motif spliceosom element forti eight rare variant human gene report alter splice caus diseas disrupt bp howev comput approach avail effici detect variant massiv parallel sequenc data establish comprehens human genom wide bp databas integr exist bp data generat new bp data rna sequenc lariat debranch enzym dbr mutat patient machin learn predict character multipl featur bp major minor intron found bp bp two nucleotid upstream bp posit exhibit lower rate variat human popul higher evolutionari conserv intron background compar exon background develop bphunter genom wide comput approach systemat effici detect intron variant may disrupt bp recognit bphunter retrospect identifi known pathogen bp variant summar strategi priorit bp variant candid remain eight variant creat ag dinucleotid bp acceptor site like reason missplic demonstr practic util bphunter prospect use identifi novel germlin heterozyg bp variant stat patient critic covid pneumonia novel somat intron nucleotid delet itpkb lymphoma patient valid experiment bphunter public avail https hgidsoftrockefelleredubphunt https githubcomcasanova labbphunt
|
D000086382
|
T047;T067
|
36,306,324
|
fluid nanopor microinterfac enabl multiscal enhanc affin interact tumor deriv extracellular vesicl detect tumor deriv extracellular vesicl ev repres valuabl marker tumor diagnosi treatment guidanc howev nanoscal size low abund marker protein ev restrict interfaci affin reaction lead low isol effici detect sensit engin fluid nanopor microinterfac fluidporefac microfluid chip decor support lipid bilay slbs nanopor herringbon microstructur multiscal enhanc affin reaction effici isol ev microscal level herringbon micropattern promot mass transfer ev surfac nanoscal level nanoporous overcom boundari effect close contact ev interfac molecular level fluid slbs afford cluster recognit molecul bind site enabl multival bind fold increas affin compar nonfluid interfac synerget enhanc mass transfer interfac contact bind affin fluidporefac afford ultrasensit detect ev limit detect ev l whose pd l express level success distinguish cancer patient healthi donor expect multiscal enhanc interfaci reaction strategi inspir biosensor design expand liquid biopsi applic especi low abund target clinic sampl
|
D058608;D000067128;D015374;D009369
|
T026;T075;T082;T191;T059
|
36,306,322
|
three dimension simul pancreat parenchyma pancreat duct vascular arrang pancreat surgeri use deep learn algorithm three dimension surgic simul alreadi use hepat surgeri use pancreat surgeri howev problem still need overcom achiev precis pancreat surgic simul present studi evalu perform synaps vincent version fujifilm medic co ltd tokyo japan semiautom surgic simul pancreat parenchyma pancreat duct peripancreat vessel use artifici intellig ai engin design deep learn algorithm one hundr pancreat cancer patient control group nonpancreat cancer patient enrol evalu method visual extract compar use dice coeffici dc pancreat cancer patient tumor size posit stagewis correl pancreat parenchym dc analyz relationship pancreat duct diamet dc manual ai measur diamet pancreat duct analyz pancreat cancercontrol group pancreat parenchym dc pancreat duct extract dc arteri portal veinsvein associ sensit specif respect correl observ pancreat parenchym dc tumor size posit stage correl observ pancreat duct diamet dc posit correl r p observ manual ai measur diamet pancreat duct extract pancreat parenchyma pancreat duct surround vessel synaps vincent ai engin assum use surgic simul
|
D000077321;D010190
|
T191;T066
|
36,306,319
|
parameter syncmer scheme improv long read map sequenc long read present novel challeng map one challeng low sequenc similar read refer due high sequenc error mutat rate occur eg cancer tumor due differ strain virus bacteria key idea map algorithm sketch sequenc minim recent syncmer introduc altern sketch method robust mutat sequenc error
|
D012984;D044962
|
T090;T170;T073;T066
|
36,306,318
|
pptps build privaci preserv audit servic traceabl timeli public cloud storag mani work design improv effici enhanc secur privaci public audit cloud storag howev build timeli cloud storag well studi work present time sensit cloud storag focus specif issu earliest creation time file resist procrastin auditor therefor leav absenc build traceabl timeli public audit cloud storag paper propos solut pptps build privaci preserv audit servic traceabl timeli public cloud storag first use secur properti blockchain provid time stamp phase enabl timeli cloud storag second construct effici public verifi cloud storag third custom random mask solut propos prevent privaci leakag audit phase moreov formal prove secur pptps last experiment result demonstr pptps econom sound technic viabl
|
D018907;D000081186
|
T033;T089;T066
|
36,306,317
|
separ human motor memori reach adapt forc cue judg breadth motor repertoir daili activ clear learn differ task hallmark human motor system howev reach adapt differ forc field condit possibl laboratori set remain challeng question previous work shown independ movement represent goal enabl dual adapt consid import forc feedback limb control hypothesis independ cue deliv mean background load could support simultan adapt various veloc depend forc field ident kinemat plan movement goal demonstr seri experi inde healthi adult adapt opposit forc field independ direct background forc cue howev cue forc field direct differ heir magnitud format differ motor represent still observ associ mechan subject increas interfer final highlight paradigm allow dissoci trial trial adapt onlin feedback adapt two mechan associ differ time scale identifi reliabl reproduc comput model
|
D003463;D007858
|
T078;T062;T041;T061
|
36,306,316
|
statist model covid infect patient data kingdom saudi arabia object studi construct new distribut known weight burr hatk distribut wbhd pdf cdf wbhd deriv close form moment incomplet moment quantil function propos distribut deriv mathemat eleven estim techniqu estim distribut paramet discuss numer simul utilis evalu various approach use partial overal rank accord find studi recommend maximum product space mpse estim wbhd best estim accord overal rank tabl actuari measur deriv suggest distribut contrast wbhd competit distribut use two differ actual data set collect covid mortal rate show import flexibl wbhd
|
D000086382
|
T047;T067
|
36,306,315
|
correl analysi combin layer multiplex network base entropi interact layer multiplex network would generat new structur featur promin featur exist link overlap layer captur associ network behavior structur interact combin layer multiplex network critic issu paper new structur entropi propos combin overlap link combin layer multiplex network correl layer evalu structur entropi result consist behavior exhibit network addit valid applic propos method verifi conduct trial four set real multiplex network data includ multiplex social network research depart aarhus tailor shop multiplex network c elegan multiplex network network collect vicker seventh grade student school victoria
|
D017173
|
T204
|
36,306,314
|
influenc trip distanc popul densiti intra citi mobil pattern tokyo covid pandem studi investig influenc infect case covid two non compulsori lockdown human mobil within tokyo metropolitan area use data hour stay popul mm cell citi level resid show long distanc trip trip crowd place decreas signific infect case increas result hold two lockdown although second lockdown less effect henc japanes non compulsori lockdown influenc mobil similar way increas infect case mean accept alarm trigger peopl risk contract covid
|
D000086382
|
T047;T067
|
36,306,305
|
contrast propos extens lstm network weak supervis object detect weak supervis object detect wsod attract attent sinc use imag level label save huge annot cost wsod method use multipl instanc learn mil basic framework regard instanc classif problem howev method base mil tend converg discrimin region differ instanc rather correspond complet region insuffici integr inspir human habit observ thing propos new method compar initi propos extend one optim initi propos specif propos one new strategi wsod involv contrast propos extens cpe consist multipl direct contrast propos extens cpes cpe contain lstm base encod dual stream decod first boundari initi propos mil extend differ posit accord well design sequenti order cpe compar extend propos initi one extract featur semant use encod calcul integr initi propos optim score contrast contextu semant guid basic wsod suppress bad propos improv score good one addit simpl dual stream network design decod constrain tempor code lstm improv perform wsod experi pascal voc voc ms coco dataset show method achiev state art result
|
D055549
|
T109
|
36,306,288
|
dual role essenti htraomi proteas human malaria parasit mainten mitochondri homeostasi induct apoptosi like cell death cellular stress member htra famili serin proteas known play role mitochondri homeostasi well program cell death mitochondri homeostasi metabol crucial surviv propag malaria parasit within host function character plasmodium falciparum htra pfhtra protein harbour trypsin like proteas activ inhibit specif inhibitor ucf transgen parasit line generat use ha glms c termin tag approach local well induc knock pfhtra pfhtra local parasit mitochondrion asexu life cycl genet ablat pfhtra caus signific parasit growth inhibit decreas replic mtdna increas mitochondri ros product caus mitochondri fissionfragment hinder parasit develop howev ucf treatment affect parasit growth suggest non proteasechaperon role pfhtra parasit cellular stress condit inhibit pfhtra ucf reduc activ caspas like proteas well parasit cell death suggest involv proteas activ pfhtra apoptosi like cell death parasit cellular stress condit pfhtra get process remain local mitochondrion suggest act within mitochondrion cleav intra mitochondri substrat support tran express pfhtra proteas domain parasit cytosol unabl induc cell death parasit overal show specif role pfhtra maintain mitochondri homeostasi well regul stress induc cell death
|
D010271;D008288
|
T047;T204
|
36,306,287
|
piperaquin resist pfcrt mutat differenti impact drug transport hemoglobin catabol parasit physiolog plasmodium falciparum asexu blood stage emerg plasmodium falciparum parasit resist dihydroartemisinin piperaquin ppq southeast asia threaten plan increas global use first line antimalari combin high level ppq resist appear mediat primarili novel mutat p falciparum chloroquin resist transport pfcrt enhanc parasit surviv high ppq concentr vitro increas risk dihydroartemisinin ppq treatment failur patient use isogen dd parasit express contemporari pfcrt allel differenti vitro ppq suscept herein character molecular physiolog adapt defin ppq resist vitro use drug uptak cellular heme fraction assay report fi ml gv pfcrt mutat differenti impact ppq chloroquin efflux mutat also modul proteolyt degrad host hemoglobin chemic inactiv reactiv heme speci peptidom analys reveal signific higher accumul putat hemoglobin deriv peptid ppq resist mutant pfcrt isoform compar parent ppq sensit dd joint transcriptom metabolom profil late trophozoit ppq resist sensit isogen line reveal differenti express gene involv protein translat cellular metabol ppq resist parasit also show increas suscept inhibitor p falciparum aminopeptidas oper short globin deriv peptid result reveal uniqu physiolog chang caus gain ppq resist highlight potenti therapeut valu target peptid metabol p falciparum
|
D010271;D016778;D000962;D037621
|
T121;T047;T204;T109
|
36,306,286
|
agrivolta model relat import longwav radiat solar panel agrivolta integr photovolta power product agricultur plot land potenti reduc land competit reduc crop irrig increas solar panel effici optim agrivolta system crop growth energi pathway must character solar panel shade crop also emit longwav radiat partial block ground downwel longwav radiat deeper understand spatial variat incom energi would enabl control alloc energi design agrivolta system model also demonstr longwav energi neglect consid full energi balanc soil solar panel
|
D000383;D012993
|
T090;T070
|
36,306,283
|
risk cervic precanc among hpv negat women netherland associ previous hpv cytolog result follow analysi random screen studi human papillomavirus hpv base screen program still use one size fit protocol effici efficaci program may improv stratifi women base previous screen result
|
D018290;D030361;D002583
|
T047;T191
|
36,306,282
|
competit model predict admiss score colleg univers chines colleg entranc examin predict admiss score colleg univers signific high school graduat colleg entranc examin china also call gaokao short practic parallel applic student gaokao put forward question student could make best score make best choic also result strong competit among differ colleg univers institut strive admit high perform student examin howev exist prevail predict algorithm model admiss score colleg univers base machin learn method take competit relationship consider simpli make predict individu colleg univers caus low predic accuraci poor general capabl paper intend analyz competit relationship extract import featur eg project locat score discrep colleg univers novel competit model incorpor coars cluster thus propos make predict colleg univers cluster use gaokao data shanxi provinc china testifi propos model comparison sever benchmark method experiment result show precis within error point point higher respect second best algorithm proven competit model capabl fit competit relationship thus improv predic accuraci larg extent theoret method propos could provid advanc comprehens view analysi factor may influenc admiss score higher institut practic model propos high accuraci could help student make best score appli colleg univers scientif
|
D013334;D012574
|
T081;T092;T098;T073
|
36,306,280
|
proxim biotinyl assay host protein bait reveal multipl factor modul enterovirus replic ultim parasit virus depend host factor everi step life cycl hand cell evolv multipl mechan detect interf viral replic yet understand complex ensembl pro anti viral factor limit virtual everi virus cell system investig protein recruit replic organell poliovirus repres genus enterovirus picornavirida famili took advantag strict depend enterovirus replic host protein gbf establish stabl cell line express truncat gbf fuse apex peroxidas effect support viral replic upon inhibit endogen gbf construct biotinyl multipl host viral protein replic organell among viral protein polyprotein cleavag intermedi overrepres suggest gbf environ link viral polyprotein process proteom character biotinyl host protein identifi multipl protein previous associ enterovirus replic well new factor recruit replic organell rna metabol protein mani normal local nucleus constitut largest group underscor massiv releas nuclear factor cytoplasm infect cell involv viral replic function analysi sever newli identifi protein reveal pro anti viral factor includ novel compon infect induc stress granul deplet protein similar affect replic divers enterovirus indic broad conserv replic mechan thus data signific expand knowledg composit enterovirus replic organell provid new insight viral replic offer novel resourc identifi target anti viral intervent
|
D004770;D017955;D004769
|
T005;T047
|
36,306,276
|
novel complement factor b gene mutat identifi kidney transplant recipi shiga toxin trigger episod thrombot microangiopathi background atyp hemolyt urem syndrom ahus ultra rare disord character activ dysregul altern complement pathway clinic present diseas compris thrombocytopenia microangiopath hemolyt anemia acut kidney injuri case ahus caus genet mutat compon altern complement pathway risk graft loss patient kidney transplant ahus depend type genet mutat case report present case year old patient second kidney transplant atyp hemolyt urem syndrom whose clinic manifest trigger shiga toxin produc e coli infect genet test reveal new mutat pit gene encod complement factor b cfb sinc causat variant ahus describ exon cfb gene might suppos pit variant similar deleteri effect cfb function despit implement treatment graft function deterior patient return hemodialysi program current wait list third kidney transplant presenc gene variant increas suscept ahus recurr kidney transplant make patient good candid therapi complement factor c inhibitor plan kidney transplant conclus case confirm import genet test patient sign thrombot microangiopathi find shiga toxin induc hus typic clinic cours limit vigil complement mediat hus high risk renal failur
|
D065766;D016030;D057049;D004927
|
T061;T047
|
36,306,275
|
quantifi micromolar crystallin pharmaceut materi util f solid state nmr quantifi low level compon solid state analysi present signific challeng thermal diffractometr vibrat spectroscop techniqu pharmaceut analysi identifi quantifi physic form drug substanc solid dosag critic task ensur qualiti drug product exampl recrystal activ pharmaceut ingredi amorph solid dispers compromis stabil bioavail drug product herein develop demonstr fluorin solid state nuclear magnet reson f ssnmr method push boundari quantifi minor crystallin content amorph pharmaceut calibr curv suggest f direct polar h f cross polar ssnmr readili quantifi ww crystallin compound commerci fluorin drug molecul develop merck co inc rahway nj usa amorph formul h f multipl cross polar multicp implement first time compar convent cross polar method import relax filter f ssnmr method util unambigu identifi quantifi low ww crystallin compon mol mg tablet drug load suppress signal amorph counterpart low level detect offer high confid sensit quantifi trace amount phase chang pharmaceut amorph materi solid state facilit formul develop well qualiti control
|
D066235
|
T060
|
36,306,271
|
syphili multipl pulmonari nodul bone lesion detect comput tomographi f fluorodeoxyglucos positron emiss tomographycomput tomographi syphili caus wide rang system manifest papular rash malais weight loss muscl ach general lymphadenopathi mening howev pulmonari involv patient secondari syphili thought relat rare moreov bone involv patient secondari syphili also consid rare case involv lung bone patient report paper report case secondari syphili pulmonari involv form multipl nodul low attenu area lymphadenopathi multipl bone lesion detect comput tomographi f fluorodeoxyglucos positron emiss tomographycomput tomographi
|
D055613;D013587;D000072281
|
T033;T047
|
36,306,267
|
atrial impair marker discrimin takotsubo acut myocard use cardiac magnet reson purpos studi comprehens compar left right atrium strain strain rate sr paramet cardiac magnet reson cmr patient takotsubo ts patient acut myocard
|
D016279;D009205
|
T047;T042
|
36,306,265
|
chemoproteom identif blue light damag protein visibl light particular blue region spectrum caus cell dysfunct generat singlet oxygen contribut cellular age age relat patholog although photooxid nucleic acid lipid amino acid extens studi magnitud span blue light induc protein damag within proteom remain larg unknown herein present chemoproteom approach map blue light damag protein live mammalian cell exploit nucleophil alkyn chemic probe gene ontolog enrich analysi reveal cell surfac protein readili oxid suscept set protein includ mitochondri protein particular integrin famili cell surfac receptor itg high rank mammalian cell test includ human corneal endotheli cell blue light oxid itgb protein function inact promot cell adhes prolifer suggest photodamag integrin contribut blue light induc cell dysfunct applic method various cell tissu lead comprehens analysi light sensit protein
|
D042783;D026082
|
T123;T196;T025
|
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