PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
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stringlengths 4
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|---|---|---|---|
36,305,868
|
multiplex microfluid platform stem cell deriv pancreat islet cell stem cell deriv cell offer altern primari islet biomed discoveri well potenti surrog islet transplant expens challeng obtain maintain function stem cell deriv cell call need develop better high content high throughput cultur system microphysiolog system mps promis high content vitro platform scale high throughput screen discoveri remain challeng tradit simultan multiplex liquid handl cell load pose challeng design high throughput mps furthermor although mps islet culturetest develop studi multi day cultur stem cell deriv cell mps limit present scalabl multiplex islet mps devic incorpor microfluid gradient generat parallel fluid handl cultur test condit demonstr viabil function stem cell deriv enrich cluster ebc week assess fold insulin releas cluster glucos challeng show scalabl multiplex drug test demonstr loss stimul index long term exposur logarithm concentr rang glybenclamid mps cultur ebc also confirm glycolyt bottleneck infer insulin secret respons metabolit methyl succin glycer acid thus present innov cultur platform ebc balanc high content high throughput characterist
|
D050417;D007515
|
T023;T025
|
36,305,863
|
perspect path sampl method appli enzymat catalysi perspect review use transit path sampl method studi enzymat catalyz chemic reaction first appli group enzymat reaction year ago method uncov basic principl enzymat catalysi protein promot vibrat also help harmon idea electrostat preorgan dynam view enzym function use help uncov principl protein design necessari artifici enzym creation
|
D011506;D014732
|
T123;T070;T116
|
36,305,844
|
funni current essenti fight flight respons cardiac pacemak cell sympathet nervous system fight flight respons character rapid increas heart rate mediat increas spontan action potenti ap fire rate pacemak cell sinoatri node sympathet neuron stimul sinoatri myocyt sam activ adrenerg receptor ar increas camp funni current among camp sensit current sam critic pacemak activ howev role fight flight respons remain controversi studi use ap waveform analysi machin learn dynam clamp experi acut isol sam mice quantit defin ap waveform chang role fight flight increas ap fire rate found ar stimul signific alter near ap waveform paramet increas fire rate correl chang subset paramet diastol durat late ap durat diastol depolar rate dynam clamp inject ar sensit compon show account fight flight increas ap fire rate decreas interv ap thus essenti contributor fight flight increas heart rate
|
D012849;D032383
|
T023;T025
|
36,305,833
|
structur mechan type g crispr effector type crispr system common crispr type found bacteria use multisubunit effector guid crrna detect bind dsdna target form r loop recruit cas enzym facilit target dna destruct thus provid immun mobil genet element subtyp classifi famili g type g least well understood report composit structur function type g cascad crispr effector thioalkalivibrio sulfidiphilus reveal key new molecular detail uniqu csb subunit process pre crrna remain bound end matur crrna seven cas subunit form backbon effector cas associ stabli effector complex via casg subunit import target dna recognit structur analysi cryo electron microscopi reveal strike curv backbon conform casg span belli structur biochem structur insight shed new light divers type system open way applic genom engin
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D064130;D042001;D001426
|
T123;T007;T116
|
36,305,830
|
optim pore space partit metal organ framework use bioisoster concept pore space partit psp method suit dramat increas densiti guest bind site lead partit ac pac platform capabl record high uptak co small hydrocarbon c h x gas separ achiev high select amid psp enabl high uptak offer entic prospect aim high select introduc bioisoster bis concept wide use drug design strategi realm pore space partit mof new pac materi high c h co select high c h uptak cm g k atm high separ potenti mmolg lead excel experiment breakthrough perform metric coupl except tunabl high stabil low regener energi demonstr broad potenti bis psp strategi
|
D000073396
|
T109
|
36,305,821
|
vitamin c enhanc nf b driven epigenom reprogram boost immunogen properti dendrit cell dendrit cell dcs potent antigen present cell necessari effect activ nave cell dcs immunolog properti modul respons various stimuli activ dna demethyl crucial dc differenti function vitamin c known cofactor ten eleven transloc tet enzym drive activ demethyl vitamin c recent emerg promis adjuv sever type cancer howev effect human immun cell poor understood studi investig epigenom transcriptom reprogram orchestr vitamin c monocyt deriv dc differenti matur vitamin c trigger extens demethyl nf bp bind site togeth concord upregul antigen present immun respons relat gene dc matur p interact tet mediat aforement vitamin c mediat chang demonstr pharmacolog inhibit moreov vitamin c increas tnf product dcs nf b concord upregul code gene demethyl adjac cpgs final vitamin c enhanc dc abil stimul prolifer autolog antigen specif cell propos vitamin c could potenti improv monocyt deriv dc base cell therapi
|
D001205;D003713;D016328;D044127
|
T129;T121;T025;T127;T109;T116;T045
|
36,305,817
|
postmortem diffus weight magnet reson imag brain perinat death anim control studi detect influenc postmortem interv diffus weight imag may use part postmortem magnet reson imag protocol howev apart effect temperatur appar diffus coeffici adc normal postmortem adc chang influenc interpret therefor studi conduct evalu correl normal adc chang postmortem interv pmis develop refer standard postmortem chang temperatur correct
|
D066087
|
T033
|
36,305,816
|
guard protein mediat qualiti control mechan monitor cap pre mrnas effici gene express requir proper matur mrnas function transcript translat sever factor includ guard protein monitor matur act nuclear retent factor unprocess pre mrnas show guard protein npl monitor cap absenc uncap transcript resist degrad rat rai end degrad factor effici recruit faulti transcript import npl improp cap transcript escap qualiti control checkpoint leak cytoplasm data suggest model npl associ rai bound pre mrnas case transcript proper cap thus cbc cap bind complex bound rai dissoci npl allow export factor mex interact guard protein support nuclear export case npl detect proper cap cbc attach rai bind persist rat join complex degrad faulti transcript
|
D009687;D012322;D016601;D029701;D012315
|
T123;T116;T114
|
36,305,813
|
atm mediat ell phosphoryl enhanc self associ increas eaf interact inhibit global transcript genotox stress mammalian cell immedi inhibit transcript upon exposur genotox stress avoid fatal collis ongo transcript newli recruit dna repair machineri protect genom integr howev mechan earli transcript inhibit poor understood studi deciph novel role human eaf posit regul ell depend rna polymeras ii mediat transcript vitro regul tempor inhibit transcript genotox stress result show besid super elong complex sec littl elong complex lec human ell aka ell also form complex eaf alon interest contrari vitro studi eaf inhibit ell depend rna polymeras ii mediat transcript divers target gene mechanist show intrins self associ properti ell lead reduc interact sec compon eaf enhanc ell self associ thus reduc interact sec compon lead transcript inhibit physiolog show upon exposur genotox stress atm mediat ell phosphoryl depend enhanc eaf associ result reduc ell interact sec compon lead global transcript inhibit thus describ import mechan dynam transcript regul genotox stress involv post translat modif key elong factor
|
D064007;D014157;D035602
|
T123;T126;T116
|
36,305,789
|
viral protein engag gbf induc host cell vulner synthet lethal virus co opt host protein carri lifecycl repurpos host protein may thus becom function compromis situat analog loss function mutat term host protein viral induc hypomorph cell bear cancer driver loss function mutat success target drug perturb protein encod synthet lethal sl partner cancer specif mutat similar sl interact viral induc hypomorph potenti target host base antivir therapeut use gbf support infect mani rna virus proof concept gbf becom hypomorph upon interact poliovirus protein screen sl partner gbf reveal arf top hit disrupt select kill cell synthes alon context poliovirus replicon thus viral protein interact induc hypomorph render host cell select vulner perturb leav uninfect cell otherwis unscath exploit viral induc vulner could lead broad spectrum antivir mani virus includ sar cov
|
D020662;D017955;D014758
|
T123;T005;T126;T116
|
36,305,785
|
light initi c h activ via net hydrogen atom transfer molybdenum vi dioxo moo cl bpi bu shown potent one electron oxid upon irradi nm light various solvent weak two electron oxid dark complex character activ various type c h bond photochem includ allyl benzyl posit well alkan aldehyd oxid ultim form bimetal mo v mo v speci oxo ligand depend substrat major organ product identifi either oxygen c c coupl homodimer compound along minor chlorin speci product select propos depend upon relat valu bond dissoci enthalpi bde potenti new c oh bond within product versus bde mo oh motif within mo v oh intermedi base estim bde mo oh kcalmol mechanist studi suggest c h activ occur via net hydrogen atom transfer hat occur either asynchron via stepwis electron proton transfer et pt process complex demonstr reform dioxo presenc chemic oxid
|
D006859;D011522
|
T196
|
36,305,769
|
kincsm use graph base signatur predict small molecul cdk inhibitor protein phosphoryl act essenti onoff switch mani cellular signal pathway led ongo interest target kinas therapeut intervent comput aid drug discoveri proven use cost effect approach facilit priorit enrich screen librari limit effort devot provid insight make potent kinas inhibitor fill gap develop kincsm integr comput tool capabl accur identifi potent cyclin depend kinas cdk inhibitor quantit predict cdk ligand kinas inhibit constant pki classifi differ type inhibitor base favor bind mode kincsm predict model built use supervis learn leverag concept graph base signatur captur physicochem properti geometri properti small molecul cdk inhibitor accur identifi matthew correl coeffici mcc inhibit constant predict pearson correl consist perform nonredund blind test respect kincsm also abl identifi potenti type inhibit given molecul achiev mcc cross valid blind test analyz molecular composit reveal enrich chemic fragment cdk inhibitor differ type inhibitor provid insight molecular mechan behind ligand kinas interact kincsm invalu tool guid futur kinas drug discoveri aid fast accur screen cdk inhibitor kincsm freeli avail https biosiglabuqeduaukincsm
|
D047428;D000970
|
T121;T116;T109
|
36,305,768
|
chaperon activ cyclophilin famili prevent tau aggreg tauopathi alzheim diseas character misfold progress accumul microtubul associ protein tau chaperon task maintain protein homeostasi becom imbalanc age contribut progress neurodegen diseas cyclophilin promis pool underinvestig chaperon peptidyl prolyl isomeras activ may play protect role regul tau aggreg use thioflavin fluoresc base assay monitor vitro tau aggreg eight cyclophilin includ ppia ppih prevent tau aggreg ppib ppic ppid ppih show greatest inhibit low thermal stabil ppid strong heparin bind ppib undermin simplist interpret reduc tau aggreg cellular model tau accumul cyclophilin except ppid ppih reduc insolubl tau ppib ppic ppie ppif also reduc solubl tau level ppic exclus protect cell tau seed overal studi demonstr cyclophilin prevent tau fibril format mani reduc cellular insolubl tau accumul ppic greatest potenti molecular tool mitig tau seed accumul
|
D019636;D000544
|
T047;T048
|
36,305,767
|
design optim enzymat activ de novo barrel scaffold nativ scaffold offer larg divers shape topolog enzym engin often unpredict behavior respons sequenc modif make de novo generat scaffold excit altern explor custom backbon sequenc de novo design eight strand barrel protein creat catalyst retro aldolas model reaction show activ specif catalyst design fold use direct evolut optim activ stereoselect result support previous suggest differ fold differ inher amen evolut properti could account part distribut natur enzym among differ fold
|
D011506;D015202
|
T063;T123;T116
|
36,305,766
|
molecular determin traf bind specif suggest nativ interact partner optim affin traf adaptor protein involv signal pathway essenti develop immun system particip mani protein protein interact mediat c termin math domain bind short peptid segment contain motif pxexx fywhd x amino acid block math domain interact associ favor effect various diseas model better defin traf math domain bind prefer screen combinatori librari use bacteri cell surfac peptid display identifi best traf interact peptid set peptid match sequenc pxe bind traf math peptid enrich screen bound traf tighter previous measur nativ peptid better understand structur basi traf interact prefer built atom structur model math domain complex high affin binder nonbind identifi screen identifi favor interact motif featur binder well negat design element distribut across motif disfavor preclud bind search human proteom reveal biolog relev traf motif match occupi differ sequenc space best hit discov combinatori librari screen suggest nativ interact optim affin experiment determin bind prefer structur model support design peptid base interact inhibitor higher affin endogen traf ligand
|
D048029;D010455
|
T123;T121;T116
|
36,305,765
|
evolutionari trajectori receptor bind specif promiscu spike protein sar cov sar cov infect cell attach receptor angiotensin convert enzym ace regardless wealth structur data littl known physicochem mechan interact viral spike protein ace mechan evolv pandem appli experiment comput approach character molecular interact protein sar cov variant concern voc data kinet activ equilibrium thermodynam bind receptor bind domain rbd voc ace well data comput protein electrostat reveal profound remodel physicochem characterist interact evolut thus compar rbds wuhan strain voc omicron rbd present uniqu protein term conform dynam type non coval forc drive complex format ace viral evolut result restrict rbd structur dynam shift major role polar forc ace bind investig reshap physicochem characterist interact affect bind specif protein data various bind assay reveal sar cov wuhan omicron rbds manifest capac promiscu recognit unrel human protein harbor distinct reactiv pattern find might contribut mechanist understand viral tropism capac evad immun respons evolut
|
D000086402;D000086382
|
T005;T067;T047
|
36,305,764
|
hdock updat model protein rnadna complex structur protein nucleic acid interact involv various cellular process therefor determin structur protein nucleic acid complex provid insight mechan interact thus guid ration drug design modul interact due high cost technic difficulti solv complex structur experiment comput model molecular dock play import role studi molecular interact order make easier research obtain biomolecular complex structur molecular dock develop hdock server protein protein protein rnadna dock access http hdockphyshusteducn sinc first releas hdock wide use scientif communiti nucleic acid may includ singl strand ss rnadna doubl strand ds rnadna present updat version hdock offer new option structur model ssrna ssdna dsrna dsdna hope updat better help scientif communiti solv import biolog problem therebi advanc field articl describ general protocol hdock emphasi new function rnadna model sever applic exampl also given illustr usag new function
|
D012313;D012984
|
T090;T170;T073;T114
|
36,305,763
|
intrins protein disord uncoupl affin bind specif intrins disord protein idp intrins disord region idr protein often function molecular recognit undergo induc fold base prior general idea prevail idp field due entrop penalti induc fold major function advantag associ bind mode uncoupl specif bind strength nevertheless weaker bind high specif idpsidr rest limit experiment observ make assumpt specul evid support fact issu also complic rather vagu concept specif lack exact measur kd bind strength address issu creat analyz comprehens dataset well character idglobular protein complex atom structur complex free energi g kd interact known analysi provid evid affin distribut idpglobular globularglobular complex show differ trend wherea specif connot weaker bind strength idpsidr furthermor protein disord extend spectrum direct weak interact may import regulatori consequ suggest biolog sens strict correl specif bind strength uncoupl structur disord
|
D007290;D064267
|
T123;T121;T116;T114
|
36,305,740
|
conclud remark challeng futur develop biolog electron cryo microscopi past year biolog electron cryo microscopi cryoem undergon process rapid transform mani thing could dream decad ago becom almost routin nevertheless number challeng remain sampl prepar correl tomograph analysi light microscopi data valid grow impact artifici intellig structur predict year faraday discuss examin challeng detail conclud remark present concis summari meet brief outlook futur
|
D001185;D004583
|
T090;T073;T196;T066;T081
|
36,305,711
|
immunoregulatori signal network tumor immun evas mechan insight therapeut target agent clinic develop activ immun cell immun system respons identifi destroy infect otherwis damag cell includ tumorigen cell recogn foreign thus maintain homeostasi howev tumor cell evolv sever mechan avoid immun cell detect kill result tumor growth progress tumor microenviron tumor infiltr immun cell inactiv solubl factor tumor promot condit lose effect tumor cell analysi signal crosstalk immun cell tumor cell help us understand detail mechan tumor immun evas form basi drug develop strategi area cancer immunotherapi review summar domin signal network involv immun escap describ status develop therapeut strategi target tumor immun evas mechan focus tumor microenviron interact cell
|
D019139;D009369
|
T046;T191
|
36,305,710
|
import access extracellular juxtamembran stalk region membran protein substrat recognit viral ubiquitin ligas k kaposi sarcoma associ herpesvirus kshv carcinogen virus latent infect b cell caus malign tumor immunocompromis patient kshv util two viral e ubiquitin ligas k k kshv infect cell mediat polyubiquitin depend regul sever host membran protein involv immun system although k k member famili similar structur topolog k k differ substrat specif henc k may differ substrat recognit mode k howev molecular basi substrat recognit remain unclear investig reason human cd known substrat k k recogn obtain understand molecular basi substrat specif cd form disulfid link homodim experiment condit evalu viral ligas mediat regul known two interchain disulfid linkag stalk region cd monom cys cys cys cys mediat homodimer interchain disulfid linkag cys cys elimin cd regul k function ring variant ringv domain via polyubiquitin cytoplasm tail aspart acid locat stalktransmembran interfac cd essenti k mediat regul cd mutant without cys cys linkag result suggest disulfid linkag near stalktransmembran interfac critic inhibit substrat target k access extracellular juxtamembran stalk region membran protein may import substrat recognit viral ubiquitin ligas k
|
D017874;D019288
|
T123;T005;T116
|
36,305,701
|
oxid induc precondit pharmacolog approach trigger renal self defens acut kidney injuri aki common event occur hospit icu patient respect develop aki portend increas risk morbid mortal prolong hospit subsequ develop chronic kidney diseas ckd given fact multitud experiment studi address potenti method induc aki prevent high risk patient howev success clinic translat promis experiment data remain elus past decad laboratori focus develop method safe trigger aki protect induc kidney precondit mice intraven administr combin fe sucros fes tin protoporphyrin snpp agent induc mild short live oxid stress synergist activ number kidney self defens pathway eg nrf ferritin il within h fesnpp administr mark protect divers form experiment toxic ischem aki result fessnpp mediat reduct kidney injuri also indirect decreas injuri organ mitig call organ cross talk phenomenon given promis experiment data three phase b clinic trial undertaken healthi subject patient stage ckd studi demonstr fessnpp well toler regul cytoprotect nrf ferritin il pathway two subsequ phase trial conduct patient undergo pump cardiovascular surgeri patient hospit covid confirm fessnpp safeti furthermor interim data analys reveal statist signific improv sever clinic paramet goal review briefli discuss histor background renal precondit ii present experiment data support concept fessnpp induc organ protect iii discuss initi result clinic trial suggest potenti clinic util oxid precondit strategi
|
D000086382;D058186;D051436
|
T047;T037;T067
|
36,305,681
|
intermitt fast exercis therapi abat stz induc diabetotox rat modul adipocytokin hormon oxid glucos metabol glycolyt pathway diabet global cost grow public health issu intermitt fast exercis therapi shown improv insulin sensit larg studi although under process still unknown goal studi includ nondiabet diabet rat look mechan intermitt fast exercis manag diabetotox effect starvat honey oral glucos toler test insulin toler test adipocytokin oxid glucos metabol enzym glycolyt enzym food intak bodi weight rat streptozotocin induc diabet also investig nondiabet phase rat administ oral regimen distil water mlrat honey gkg bodi weight intervent starvat week diabet phase stz citrat buffer inject intervent exercis starvat honey treatment began week ogtt itt point substanti rise glucos stz group adipocytokin hormon oxid glucos metabol enzym glycolyt enzym bodi weight affect stz compar starvat honey howev exercis signific reduc alter diabet rat intermitt fast exercis enhanc serum adipocytokin level find impli adipokin modul glycolyticnonmitochondri enzym glucos metabolicmitochondri dehydrogenas mediat antidiabet effect intermitt fast exercis
|
D003921
|
T050
|
36,305,679
|
thoracoabdomin aortic aneurysm repair base pre postop evalu arteri adamkiewicz aim studi evalu experi thoraco abdomin aortic aneurysm repair base pre postop evalu arteri adamkiewicz aka
|
D017545;D013119;D017544
|
T047;T037
|
36,305,674
|
underwat hear sea duck applic reduc gillnet bycatch acoust deterr dive forag sea duck vulner underwat anthropogen activ includ ship underwat construct seismic survey gillnet fisheri bycatch gillnet contribut sourc mortal sea duck kill hundr thousand individu annual research underwat hear sea duck speci increas knowledg underwat avian acoust sensit assist possibl develop gillnet bycatch mitig strategi includ auditori deterr devic use psychoacoust electrophysiolog techniqu investig underwat duck hear sever speci includ long tail duck clangula hyemali surf scoter melanitta perspicillata common eider somateria mollissima psychoacoust result demonstr speci test share common rang maximum auditori sensit khz long tail duck common eider high end rang khz surf scoter low end khz addit electrophysiolog result surf scoter long tail duck test khz general agre audiogram shape psychoacoust test result studi applic develop effect acoust deterr devic pinger khz rang deter sea duck anthropogen threat
|
D004372;D005398
|
T092;T012
|
36,305,672
|
structur switchabl hairpin power exponenti replic sens attomolar microrna relat singl nucleotid polymorph human cancer tissu zero background microrna mirna relat singl nucleotid polymorph mir snps novel class genet variat involv multipl cellular function emerg promis biomark cancer diagnost prognost herein demonstr first time structur switchabl hairpin power exponenti replic sens attomolar mir snps human cancer tissu zero background presenc target mir hairpin probe ie hp hp splint togeth construct dumbbel shape probe dsp splintr ligas catalysi dsp form self prime polymer extens linear fipbip prime strand displac dna synthesi sds automat repeat activ self circul exponenti amplif produc larg amount doubl strand dnas dsdnas real time monitor use sybr green nanodevic detect mir ultralow detect limit distinguish rare mir snp select factor even profil mir human tissu nonsmal cell lung cancer nsclc diagnosi risk assess cancer type predict notabl nanodevic rapid homogen use one tube real time label free manner provid power point care platform noninvas diagnost prognost mir snps relat human cancer
|
D035683;D002289;D008175
|
T123;T191;T114
|
36,305,644
|
role uv ddb process oxoguanin base excis repair recent data laboratori shown nucleotid excis repair ner protein uv damag dna bind protein uv ddb xeroderma pigmentosum group c xpc xeroderma pigmentosum group xpa play import role process oxog review first discuss biochem studi demonstr uv ddb stimul human oxog glycosylas ogg mutyh apurinicapyrimidin ap endonucleas ape increas turnov damag site discuss singl molecul studi show uv ddb associ protein abas moieti dna damag array data cell experi describ show uv ddb interact ogg site oxog final sinc mani glycosylas inhibit work damag context chromatin present work model uv ddb may first respond alter structur damag contain nucleosom allow access base excis repair ber enzym
|
D014983
|
T019
|
36,305,642
|
fundament role inter organell communic age advanc public health near doubl life expect last centuri demograph shift also chang landscap human ill today chronic age depend diseas domin lead caus morbid mortal worldwid target under molecular genet cell biolog driver age process appear increas viabl strategi develop therapeut diseas age toward end one excit develop cell biolog last decad explos research organell contact site relat mechan inter organell communic identif molecular mediat inter organell tether signal allow field investig consequ aberr organell interact frequent seem correl age onset pathophysiolog review introduc major cellular role inter organell interact includ regul organell morpholog transfer ion lipid metabolit format hub nutrient stress signal explor interact disrupt age present find modul inter organell communic promis avenu promot longev review propos mainten inter organell interact pillar healthi age learn target cellular mechan sens control inter organell communic key next hurdl gerosci
|
D000375;D015388
|
T033;T040;T026
|
36,305,641
|
percept risk date violenc among rural adolesc male interpret analysi one eight us high school student grade report experienc teen date violenc tdv form physic sexual psycholog date violenc past year person school ground onlin compar urban counterpart rural teen face near doubl rate physic date abus elev risk experienc multipl form violenc rural young male expos region masculin gender norm may simultan promot femal subordin prelud date violenc imped help seek intent use interpret dialect approach ground relat dialect theori explor rural young male perceiv describ risk experienc perpetr date violenc factor contribut help seek intent behavior data three focus group individu interview rural young male age collat identifi two central dialect theme describ social tension dialect subthem includ abus vs unhealthi relationship dialect languag metoo vs wetoo dialect victimhood countri boy dialect masculin b help seek dialect demonstr dual role religion school guidanc counselor peer mentor social cohes play promot prevent date violenc overal found dialect tension rural youth risk percept date violenc find bear implic advoc practition work rural youth plan development cultur appropri tdv prevent program offer polici research relev insight
|
D000294;D000066511
|
T055;T053
|
36,305,637
|
incom inequ raceethn obes us men year older obes signific public health problem global within unit state vari multipl factor includ limit incom literatur indic littl evid associ incom obes examin associ incom obes us adult men age year older test racial ethnic differ use data nation health nutrit examin survey analys obes determin use bodi mass index kgm use poverti incom ratio pir proxi incom calcul gini coeffici gc measur incom inequ categor low medium high pir examin relationship incom inequ obes use modifi poisson regress sampl adult men includ white non hispan white nhw non hispan black nhb mexican american control model age categori racial ethnic group marit status educ health behavior health insur coverag self report health comorbid household structur result adjust model suggest posit signific associ pir obes among nhws nhbs medium high pir associ signific mas result analys use gc obes men indic compar nhws gc se mas gc se nhbs gc se experienc higher incom inequ treat obes policymak consid raceethn strategi reduc inequ incom
|
D005006;D007182
|
T078;T081;T098;T102
|
36,305,631
|
character tumour microenviron phenotyp malign tissu pleural effus advanc osteoblast osteosarcoma patient malign pleural effus mpe advers prognost factor patient osteoblast osteosarcoma howev cellular context mpe larg unknown
|
D016066;D010996;D012516;D001859
|
T047;T191
|
36,305,615
|
report bilharziella polonica cercaria knowsley safari prescot unit kingdom note trematod implic human cercari dermat part surveil snail born trematodiasi knowsley safari ks prescot unit kingdom collect made juli various planorbid n lymnaeid n snail taken purpos select freshwat habitat laboratori emerg trematod cercaria often singl snail identifi morpholog sub set access later character cytochrom oxidas subunit cox dna barcod two schistosomatid cercaria special note context human cercari dermat hcd bilharziella polonica emerg planorbarius corneus trichobilharzia spp emerg ampullacaena balthica former schistosomatid last report unit kingdom year ago cox analys latter like consist two taxa trichobilharzia anseri first report unit kingdom hitherto unnam genet lineag affili trichobilharzia longicauda chronobiolog emerg cercaria p corneus assess vertic swim rate b polonica measur provid brief risk apprais hcd public activ typic undertaken within ks educ recreat programm
|
D012551;D012876;D014201;D012552;D003872
|
T047;T204
|
36,305,606
|
dataset ant coloni motion trajectori indoor outdoor scene studi cluster behavior motion interact social insect ant studi mani research understand cluster mechan studi field ant behavior focus indoor environ laboratori setup outdoor environ natur environ still underexplor
|
D001000
|
T204
|
36,305,603
|
vitro ferment cordycep militari polysaccharid chang simul gut condit influenc gut bacteri motil transloc motil abil intestin lipopolysaccharid lps produc bacteria determin transloc enterohepat circul work infecti complic studi health effect cordycep militari polysaccharid cmps evalu base whether polysaccharid could affect motil gut commens lps produc bacteria imped transloc result show cmp ferment gut could chang chemic environ lead decreas veloc shift motil pattern studi suggest detachmentfragment flagella decreas motor forc chang chemic condit might account weaken motil adhes invas abil gut bacteria also reduc lower express virul relat gene result indic health regul effect cmp might decreas motil lps produc bacteria hinder transloc therefor reduc lps level enterohepat circul
|
D032661;D000069196
|
T007;T004;T001
|
36,305,601
|
electrochem hydrogen co cu insight accur multiconfigur wavefunct method copper cu remain efficaci electrocatalyst electrochem co reduct co r activ select high facet depend recent examin common propos rate limit co hydrogen step cu via embed correl wavefunct ecw theori demonstr higher level theori yield predict consist potenti depend experiment kinet understand differ activ cu cu catalyz co r explor co hydrogen cu use ecw theori predict prefer pathway involv reduct adsorb co co coh via proton coupl electron transfer pcet work potenti although cho also may form kinet access higher barrier contrast earlier work cu conclud coh cho format via pcet equal feasibl work illustr one possibl origin facet depend co r mechan product cu electrod shed light select co r electrocatalyst control surfac morpholog
|
D003300;D011522
|
T123;T196;T121
|
36,305,591
|
frankenstein cas engin improv gene edit system discoveri crispr cas widespread use revolutionis propel research biolog scienc although abil target cas nucleas activ specif site via easili design guid rna grna made adapt gene edit system mani characterist could improv use biotechnolog cas exhibit signific target activ low target nucleas activ certain context scientist undertaken ambiti protein engin campaign bypass limit produc sever promis variant cas cas variant improv altern activ provid excit new tool expand scope fidel futur crispr applic
|
D000072669;D064113
|
T063;T040
|
36,305,581
|
comput model full length tsh receptor gpcr receptor tsh receptor tshr g protein coupl receptor gpcr particular interest primari antigen autoimmun hyperthyroid grave diseas caus stimul tshr antibodi date one domain extracellular region tshr crystal run ns molecular dynam simul model entir tshr generat merg extracellular region receptor obtain use artifici intellig recent homolog model transmembran domain embed lipid membran solvat water counterion simul show structur transmembran leucin rich domain remark constant linker region lr known common hing region show signific flexibl form sever transient secondari structur element furthermor relat orient leucin rich domain rest receptor also seen variabl data suggest lr intrins disord protein furthermor preliminari data simul full tshr model complex ligand tsh show strong affin lr tsh ligand b associ lr tsh ligand reduc structur fluctuat lr full length model illustr import lr respond ligand bind lay foundat studi patholog tshr autoantibodi complex tshr give insight interact flexibl lr
|
D011989;D001185
|
T090;T073;T116;T192;T066
|
36,305,559
|
exciton coupl simpl coacerv via liquidliquid phase separ viscoelast liquid coacerv phase high enrich nonconjug polyelectrolyt current subject high activ research biolog soft materi perspect howev format liquid electron activ coacerv prove high elus sinc extend electron interact strong favor solid state herein show conjug polyelectrolyt ration design undergo aqueous liquidliquid phase separ form liquid coacerv phase result signific add fundament understand liquidliquid phase separ also open intrigu applic light harvest beyond find semiconduct coacerv intrins exciton coupl allow long rang exciton diffus strong correl fluctuat environ emerg exciton state compris excim h aggreg
|
D014867
|
T121;T197
|
36,305,557
|
ambulatori pathway investig patient suspect pulmonari embol aim aim project provid ambulatori pathway diagnosi manag patient suspect pulmonari embol pe low risk featur method structur algorithm manag suspect pe design implement april involv develop local guidelin identifi low risk patient suspect pe use modifi spesi hestia criteria pathway audit month establish effect admiss hospit length stay result ct pas perform emerg depart april total number ct confirm pes april low risk patient suspect pe identifi place ambulatori suspect pulmonari embol pathway one patient pathway confirm pe patient place pathway spent signific less time emerg depart hospit greater satisfact physician use pathway conclus pathway succeed signific decreas length stay ed hospit patient suspect confirm pe
|
D011655
|
T047;T046
|
36,305,544
|
somapacitan long act growth hormon deriv treatment growth hormon defici growth hormon defici ghd character inadequ hg product anterior pituitari gland adult patient ghd increas fat mass abnorm lipid profil decreas lean bodi mass bone miner densiti decreas muscl strength exercis endur diminish qualiti life adult ghd aghd treat gh replac therapi daili subcutan inject howev administr daili inject burdensom patient affect treatment adher somapacitan new long act human gh hgh analogu administ week subcutan inject first approv us food drug administr fda gh replac therapi adult ghd becom first hgh therapi aghd administ week inject compar approv hgh therapi aghd administ daili inject articl review pharmacokinet clinic safeti data led approv somapacitan first long act gh therapi adult ghd
|
D004393;D019382
|
T121;T116;T125;T047;T101
|
36,305,543
|
disitamab vedotin novel direct antibodi drug conjug gastric cancer solid tumor antibodi drug conjug adc combin cytotox drug antibodi emerg rise star cancer therapi disitamab vedotin rc novel adc target human epiderm growth factor receptor current explor varieti malign compar convent target agent rc character wider therapeut window less toxic normal tissu review analyz structur element mechan rc besid provid landscap progress rc common malign focus rc gastric gastroesophag junction cancer brief overview urotheli breast cancer eg gynecolog cancer biliari tract cancer non small cell lung cancer myometri invas bladder cancer final also discuss futur challeng develop rc futur direct improv efficaci
|
D000970;D002289;D018796;D008175;D013274
|
T129;T121;T191;T109
|
36,305,542
|
asciminib chronic myeloid leukemia despit fact last year life expect chronic myeloid leukemia cml patient reach normal popul signific proport cml patient like fail treatment first second generat tyrosin kinas inhibitor tkis failur first line treatment common due molecular resist unbear toxic new specif compound test set fulfil unmet clinic need cml asciminib shown efficaci base alloster inhibit allow overcom resist target toxic review aim cover asciminib chang therapeut scenario cml highlight mechan action pharmacokinet efficaci toxic asciminib possibl option third line therapi patient carri resist mutat ti andor elig treatment tkis
|
D000970;D015464
|
T121;T191;T109
|
36,305,541
|
aducanumab treatment alzheim diseas alzheim diseas ad frequent neurodegen condit common caus dementia lead caus disabl death global mount evid support accumul amyloid primari caus ad patholog sprout number candid treatment engag product clearanc yet amyloid base drug candid proven effect altern pathomechan propos still current treatment limit symptomat therapi aducanumab biib fulli human monoclon igg antibodi select bind aggreg form inhibit templat activ promot clearanc deposit three earli termin trial human avail overal conflict result exist measur clinic efficaci despit object decreas burden amyloid relat imag abnorm emerg signific treatment relat advers event provid comprehens review avail evid aducanumab drug recent receiv debat acceler approv treatment mild ad us food drug administr fda
|
D000544;D061067
|
T129;T047;T116;T048
|
36,305,537
|
data set report ovarian fallopian tube primari periton carcinoma recommend intern collabor cancer report iccr move toward consist comprehens surgic patholog report cancer resect specimen key develop support evid base patient manag consist cancer stage intern collabor cancer report iccr previous develop data set report ovarian fallopian tube primari periton carcinoma publish paper provid updat data set second edit reflect chang world health organ classif femal genit tumour well minor modif data set develop panel intern recogn expert pathologist clinician consist core noncor element includ surgic patholog report detail commentari guid user includ refer data set replac wide use first edit facilit consist accur case report data collect qualiti assur research allow comparison epidemiolog patholog paramet differ popul
|
D010338;D002277
|
T191;T091
|
36,305,536
|
data set report endometri cancer recommend intern collabor cancer report iccr endometri cancer one common cancer among women intern collabor cancer report iccr develop standard endometri cancer data set provid detail recommend report resect specimen neoplasm new data set develop incorpor updat world health organ classif femal genit tumor cancer genom atlas tcga molecular classif endometri cancer major advanc endometri cancer report necessit major revis data set updat data set produc panel expert pathologist expert clinician subject intern open consult data set includ core element unanim agre upon essenti cancer diagnosi clinic manag stage prognosi noncor element clinic import essenti explanatori note provid element adopt updat data set result improv endometri cancer patient care
|
D010338;D016889
|
T191;T091
|
36,305,535
|
dataset report carcinoma cervix recommend intern collabor cancer report iccr cervic carcinoma remain one common cancer affect women worldwid despit effect screen program implement mani countri sever decad intern collabor cancer report iccr dataset cervic carcinoma first develop aim develop evid base standard consist comprehens surgic patholog report resect specimen th edit updat iccr dataset cervic cancer undertaken incorpor major chang base upon updat intern feder obstetrician gynecologist figo stage carcinoma cervix publish th edit world health organ classif femal genit tumor publish signific develop patholog aspect cervic cancer updat dataset develop panel expert gynecolog pathologist expert gynecolog oncologist period open consult revis dataset includ core noncor element report accompani detail explanatori note refer provid rational updat standard report use dataset help facilit consist accuraci data collect across differ site comparison epidemiolog patholog paramet qualiti research purpos
|
D010338;D002583
|
T191;T091
|
36,305,534
|
data set report uterin malign potenti malign mesenchym tumor recommend intern collabor cancer report iccr intern collabor cancer report iccr seek produc standard evid base protocol report tumor aim ensur cancer report generat worldwid similar high qualiti record element herein describ develop data set report uterin malign potenti malign mesenchym tumor panel expert pathologist singl clinician provid commentari rational inclus core noncor element data set incorpor recent updat th edit world health organ classif femal genit tumor address sever subject debat includ mesenchym tumor grade document extent invas mitot count role ancillari test tumor diagnosi patient manag inclus element evid base base consensus expert panel clinic relev guid standard
|
D010338;D002277;D012509
|
T191;T091
|
36,305,533
|
dataset report gestat trophoblast neoplasia recommend intern collabor cancer report iccr comprehens patholog report cancer import patient manag tumor stage prognost standard cancer dataset essenti guid patholog report consist concis manner facilit effect global cancer inform exchang comparison intern collabor cancer report iccr allianc sever nation intern patholog societi mani countri well bodi involv tumor classif stage one function iccr develop evid base standard report dataset cancer site herein report develop evid base cancer dataset iccr panel intern expert report primari uterin gestat trophoblast neoplasia present core element includ noncor element recommend inclus patholog report list respons valu provid element along explanatori commentari dataset also discuss controversi issu report gestat trophoblast neoplasia evid base structur patholog dataset develop intern effort facilit consist accur exchang comparison epidemiolog patholog paramet among differ popul countri ultim improv gestat trophoblast neoplasia patient care facilit futur research
|
D010338;D002277;D031901
|
T047;T191;T091
|
36,305,532
|
data set report carcinoma vulva recommend intern collabor cancer report iccr cogent comprehens patholog report essenti optim patient manag cancer stage prognost articl detail intern collabor cancer report iccr process develop vulval carcinoma report data set describ core noncor element includ patholog report vulval carcinoma inclus clinic macroscop microscop ancillari test consider provid definit commentari evid andor consensus base deliber element includ data set commentari also discuss controversi issu phuman papillomavirus test tumor grade measur well element show promis warrant evid base studi summari discuss updat vulval cancer stage system intern feder obstetrician gynaecologist figo also provid hope widespread implement data set facilit consist accur report data collect comparison epidemiolog patholog paramet differ popul facilit research serv platform improv patient outcom
|
D010338;D002277
|
T191;T091
|
36,305,478
|
endoparasit communiti structur anuran assemblag caatinga northeastern neotrop region amphibian widespread chordata taxon import maintain balanc terrestri aquat ecosystem brazil rich amphibian fauna howev littl known role ecolog phylogenet relationship assembl process associ endoparasit communiti herein describ endoparasit communiti anuran assemblag caatinga uniqu biom dri forest north eastern brazil studi endoparasit divers well effect bodi length bodi mass bodi volum sex parasit abund also investig influenc ecolog histor factor anuran microhabitat use endoparasit composit analys individu anuran speci distribut across five famili odontophrynida proceratophri cristicep leptodactylida leptodactylus fuscus leptodactylus vastus leptodactylus macrosternum leptodactylus troglodyt physalaemus cuvieri hylida pithecopus gonzagai scinax x signatus boana ranicep dendropsophus nanus bufonida rhinella diptycha rhinella granulosa microhylida dermatonotus muelleri found nine speci endoparasit includ seven nematod aplectana membranosa cosmocerca sp oswaldocruzia mazzai raillietnema spectan rhabdia fuelleborni schrankiana sp physaloptera sp one speci trematoda glypthelmin pseudium one non identifi cestod signific relationship endoparasit abund host bodi length bodi mass bodi volum sex phylogenet princip compon analysi show ecolog factor greater influenc endoparasit assemblag histor factor similar result show ecolog factor greater influenc anuran microhabitat use compar histor factor contribut generalist characterist present sampl endoparasit speci
|
D009348;D014200;D017162
|
T204
|
36,305,469
|
immunotherapi safe treatment sever asthma benefit allergen immunotherapi ait includ subcutan allergen immunotherapi scit sublingu allergen immunotherapi slit ige mediat asthma well establish especi dust mite review explor whether benefit ait outweigh risk sever asthmat patient
|
D001249;D063729
|
T061;T047
|
36,305,464
|
nuclear movement multinucl cell nuclear movement crucial develop mani cell type organ nuclear movement high conserv indic necess cellular function develop addit mononucl cell sever exampl cell multipl nuclei exist within share cytoplasm multinucl cell syncytia import function develop homeostasi review subset development context regul movement posit multipl nuclei well understood includ pronuclear migrat drosophila syncyti blastoderm caenorhabd elegan hypodermi skelet muscl filament fungi appli principl learn model system
|
D002467;D017173
|
T026;T204
|
36,305,462
|
pten knockout regul metabol rewir epigenet reprogram prostat cancer chemoprevent triterpenoid ursol acid pten phosphatas tensin homolog delet chromosom one frequent mutateddelet tumor suppressor gene mani human cancer ursol acid ua natur triterpenoid possess antioxid anti inflammatori anticanc effect howev pten impact metabol rewir ua modifi pten driven metabol epigenet reprogram prostat cancer pca remain unknown current studi found ua protect pten knockout ko induc tumorigenesi differ stage pca epigenom cpg methyl seq reveal ua attenu pten ko induc differenti methyl region dmrs profil transcriptom rna seq show ua abrog pten ko induc differenti express gene deg pca relat oncogen cfh msx overexpress indic ua play crucial role pten ko mediat gene regul potenti consequ cancer intercept associ analysi deg dmrs identifi mrna express tumor suppressor gene bdh oncogen epha isg nos correl promot cpg methyl status earli stage comparison group indic ua could regul oncogen tumor suppressor gene modul promot methyl earli stage prostat tumorigenesi metabolom studi show ua attenu pten ko regul cancer associ metabol like purin metabolismmetabolit correl rnaseq find glycolysisgluconeogenesi metabol well epigenet relat metabolit pyruv lactat indic ua play critic role pten ko mediat metabol epigenet reprogram consequ cancer develop context ua impact metabol rewir caus epigenet transcriptom reprogram potenti contribut overal protect prostat specif pten ko mediat pca
|
D011471;D014315
|
T191;T109
|
36,305,421
|
albino mechan new theanin rich tea cultivar fuhuang explor mechan tea albino variat high theanin format fuyun new theanin rich tea cultivar fuhuang materi studi pigment content metabolom transcriptom two cultivar analyz ultramicroelectron microscopi wide target metabolom target metabolom transcriptom result show five catechin theobromin caffein free amino acid includ theanin glutamin arginin etc identifi target metabolom amino acid content fuhuang signific higher fuyun theanin content high mgg fuhuang ultrastructur leav show chloroplast cell structur fuhuang fuzzi grana lamella arrang disord larg gap thylakoid filiform determin pigment show compar fuyun content chlorophyl b carotenoid flavonoid pigment fuhuang decreas signific import pigment relat gene chlorophyllas clh cis epoxycarotenoid dioxygenas nced flavonoid hydroxylas fh flavonoid hydroxylas f h signific chang compar fuyun fuhuang identifi signific chang metabolit scms differenti express gene deg kegg enrich analysi show scms deg signific enrich amino acid biosynthesi glutathion metabol tca cycl general albino phenotyp fuhuang may caus defici photosynthet protein chlorophyl metabol gene chlorophyl content accumul high theanin fuhuang may due low nitrogen consumpt yellow leav lack carbon skeleton amino nitrogen resourc store effect result regul metabolit relat gene express amino acid synthesi pathway theanin becom signific accumul nitrogen contain compound yellow leav
|
D028241
|
T002
|
36,305,420
|
construct applic natur stabl isotop correct matrix c label metabol flux analysi stabl isotop c label import tool analyz cellular metabol flux c distribut intracellular metabolit detect via mass spectrometri use constraint intracellular metabol flux calcul metabol flux analysi algorithm employ obtain flux distribut correspond metabol reaction network howev addit carbon element oxygen natur also natur stabl isotop eg make isotop inform element c marker interspers isotop distribut measur mass spectrometri especi molecul contain mani element lead larg error therefor essenti correct mass spectrometri data perform metabol flux calcul paper propos method construct correct matrix base python languag correct measur error due natur isotop distribut method employ basic power method construct correct matrix simpl structur easi code implement direct appli data pre process c metabol flux analysi correct method appli intracellular metabol flux analysi c label aspergillus niger result show propos method accur effect serv reliabl data correct method accur microbi intracellular metabol flux analysi
|
D064688;D053858
|
T059;T169;T044
|
36,305,419
|
proteom base screen differenti express protein skin chines merino fine sheep junken type differ gender purpos studi understand effect gender trait wool one year old male femal chines merino sheep junken type use screen differenti express protein skin tissu quantit proteom use liquid chromatographi tandem mass spectrometri lc msms data independ acquisit dia strategi follow go function annot kegg metabol pathway protein network interact analysi differenti protein obtain result show differenti express protein male femal group wherea protein regul protein regul male group comparison analysi differenti express protein relat skin hair follicl develop wool phenotyp regul regul go annot analysi differenti express protein main enrich process molecular function oxygen bind chondroitin sulfat bind heme bind glutathion peroxidas activ glutathion transferas activ biolog process cellular oxid detoxif regul muscl contract notch signal pathway calcium ion transmembran transport glutathion metabol process relat cellular compon mast cell granul nucleus sarcoplasm reticulum endoplasm reticulum lumen kegg analysi show differenti express protein involv sixteen signal pathway among mapk p signal pathway close relat wool growth develop protein network interact analysi discov cola close relat mmp sparc thbs differenti express protein might play key role wool growth develop thus studi obtain basic data reveal molecular mechan sheep wool trait differ gender
|
D040901;D053719
|
T063;T091
|
36,305,418
|
effect methotrex urinari proteom rat methotrex mtx wide use immunosuppress drug larg dose mtx use treatment cancer low dose use treatment rheumatoid arthriti ra studi aim explor effect mtx urinari proteom rat mtx given rat oral construct mtx intragastr administr rat model urin rat collect within hour give mtx urin protein rat analyz liquid chromatographi tandem mass spectrometri lc msms total differenti protein identifi protein relat effect mtx symptom ra biolog process rat reflect effect mtx bodi glutathion metabol jakstat signal pathway indic urin protein abil reflect effect mtx bodi rat spectrum differenti protein singl rat show differ individu respond drug quit differ
|
D008727;D001172
|
T121;T047;T109
|
36,305,417
|
quantit proteom reveal potenti biolog function deubiquitin enzym ubp saccharomyc cerevisia ubiquitin one revers protein post translat modif ubiquitin molecul bind target protein cascad reaction ubiquitin activ enzym ubiquitin conjug enzym ubiquitin ligas deubiquitin enzym dub remov ubiquitin residu substrat play key role format matur ubiquitin remov trim ubiquitin chain well recycl free ubiquitin chain ubp member ubiquitin specif proteas famili saccharomyc cerevisia main respons recycl intracellular free ubiquitin chain investig global biolog function ubp mutant construct homolog recombin techniqu growth rate ubp mutant lower wild type wt strain use stabl isotop label amino acid cell cultur silac combin deep coverag proteom analysi differenti express protein ubp mutant relat wild type strain systemat analyz total protein identifi studi differenti express protein filter statist analysi gene ontolog analysi found differenti express protein caus ubp loss main involv amino acid metabol redox heat shock stress etc shed light broad biolog function dub studi provid high reliabl proteom data explor biolog function deubiquitin enzym ubp understand relationship free ubiquitin homeostasi biolog process regul
|
D012441;D001686
|
T070;T004;T038
|
36,305,416
|
quantit proteom reveal abnorm liver metabol reliev effect anemarrhena rhizoma type diabet mellitus rat type diabet mellitus tdm global metabol diseas potenti life threaten complic liver metabol play vital role occurr develop diabet mellitus report chines medicin anemarrhena rhizoma ar reliev insulin resist diabet mellitus howev effect abnorm liver metabol diabet mellitus still unclear therefor extract liver protein tdm rat induc high fat diet hfd streptozotocin stz tdm rat treat ar extract obes rat fed hfd normal control rat fed normal diet tandem mass tag tmt label combin mass spectrometri ms obtain quantit proteom data bioinformat softwar use hierarch cluster analysi princip compon analysi data group volcano map differenti express protein p plot found treatment group closer normal control group indic quantit proteom data liver tissu reflect therapeut effect tdm rat key protein cluster close relat treatment screen gene ontolog go term kyoto encyclopedia gene genom kegg pathway protein cluster analyz david result show ar allevi abnorm fatti acid metabol liver tdm rat may relat regul express key protein ndufa prkarb
|
D003924;D004365;D031403
|
T123;T047;T121;T002
|
36,305,415
|
chang urin proteom acut hypox rat model purpos studi explor effect acut hypoxia urin proteom rat studi rat place hypox chamber simul plateau environ altitud hour urin sampl collect h hypoxia urinari protein profil use liquid chromatographi coupl tandem mass spectrometri lc msms compar control hypoxia total differenti express protein identifi hypoxia h group differenti express protein identifi hypoxia h group function annot analysi reveal differenti express protein involv seri biolog pathway relat hypox stress anti oxid stress glycolysi complement coagul cascad result suggest urinari proteom reflect signific chang upon acut hypox stimul find may provid approach judg hypoxia state bodi help assist detect hypoxia state
|
D020543;D053719
|
T063;T123;T116
|
36,305,414
|
transcript analysi grape respons weak light stress grape viti vinifera l product frequent expos inadequ light signific affect agronom trait via inhibit physiolog metabol development process explor mechan grape plant respond weak light stress use yinhong grape examin physiolog biochemistri characterist transcript profil differ level weak light stress result show grape seedl upon low intens shade treatment signific affect shade stress intens strengthen epidermi cell palisad tissu spongi tissu leav thinner intercellular space palisad tissu spongi tissu larger compar control activ superoxid dismutas catalas peroxidas decreas gradual addit solubl protein content increas free prolin content decreas gradual compar control signific chang plant photosynthet characterist physiolog biochemistri characterist observ high intens shade rna seq data show differenti express gene ck ck respect enrich pathway close relat plant respons stress sever signal pathway respons stress resist eg jamyc pathway mapk signal pathway activ weak light stress express level varieti gene relat antioxid polyphenol oxidas thioredoxin photosynthesi phytochrom alter weak light stress indic yinhong grape may activ antioxid relat pathway cope reactiv oxygen speci ros addit may activ express photosynthet pigment light reaction structur protein maintain photosynthesi activ research may help better understand relev physiolog respons mechan facilit cultiv grape seedl weak light
|
D027843
|
T129;T168;T116;T002
|
36,305,413
|
construct analysi transcriptom base hepatolenticular degener regulatori network transcript regulatori network wild type atpb knockout hepg cell expos copper construct bioinformat method explor potenti mechan key transcript factor pathogenesi hepatolenticular degener differenti express gene deg wild type atpb knockout hepg cell line without copper expos copper collect gene express omnibus geo databas gene ontolog go kyoto encyclopedia gene genom kegg enrich analysi perform deg induc copper key function modul gene identifi base protein protein interact ppi network moreov enrich analysi gene function modul perform final transcript regulatori network construct screen core transcript factor total gene includ regul gene regul gene select deg regul regul function modul base ppi network includ gene respect gene key function modul enrich cell substrat junction chromosom region spliceosom complex ribosom involv mrna process histon modif rna splice regul dna metabol process protein phosphoryl biolog process moreov correl transcript coregul activ dna bind transcript factor bind ubiquitin like protein ligas bind molecular function kegg analysi show gene key function modul signific enrich hepat b mapk signal pathway cellular senesc apoptosi neurotrophin signal pathway pathway neurodegener multipl diseas transcript regulatori network contain differenti express transcript factor deg among uaf nfrkb fus max srsf cebpa rxra core transcript factor may facilit studi biolog function relev molecul transcript regul hepatolenticular degener
|
D059467;D006527
|
T081;T047;T086
|
36,305,412
|
compar transcriptom analysi haustoria gymnosporangium yamada g asiaticum provid theoret basi control spread rust diseas cultiv diseas resist varieti reduc yield loss investig transcriptom differ gymnosporangium yamada gymnosporangium asiaticum haustori stage reveal special select mechan gymnosporangium speci infect host plant sequenc transcriptom haustoria rust infect leav basidiospor g yamada g asiaticum infect host obtain unigen respect real time fluoresc quantit pcr valid five gene select g yamada g asiaticum respect show express profil general consist result transcriptom analysi demonstr reliabl transcriptom data use seven databas nr go kegg kog perform gene function annot enrich analysi found gene rust main enrich cellular process translat metabol relat pathway moreov use signalp tmhmm onlin websit softwar dbcan blsat hmmer show candid effector protein contain proteas lipas haustoria g yamada g asiaticum respect furthermor use orthofind blast kak calcul softwar analyz evolutionari relationship two fungi among one one homolog gene gene pair align consid conserv select posit select five effector g asiaticum posit select one lipas signific differ found enrich express gene g yamada g asiaticum indic biolog process involv haustoria relat conserv despit typic host select speci low protein similar two speci suggest greater host select pressur signific evolutionari diverg might relat host specif select mechan haustori main purpos effector might regul physiolog process plant rather attack host direct g yamada g asiaticum might use plant lipid energi sourc
|
D059467;D010935
|
T081;T047;T086
|
36,305,411
|
analysi progress characterist retinoblastoma base singl cell transcriptom sequenc retinoblastoma rb common intraocular malign tumor infant young children key causat factor progress rb remain unclear therefor identifi gene close associ rb progress may provid import clue diseas diagnosi gene therapi howev tumor tissu strong cellular heterogen may signific differ cell function gene express among cell differ patholog state studi download singl cell transcriptom sequenc data rb tumor adjac tissu geo public databas subsequ analyz rb tumor transcript profil differ diseas durat singl cell level identifi cell group gene set potenti associ rb progress result show tumor tissu adjac tissu overal consist singl cell transcript map obvious differ distribut proport g phase cell g phase cell microglia cell cone precursor rb tumor adjac tissu furthermor role three cell popul progress rb tumor emphat analyz found earli stage rb tumor cone precursor cell prolifer abnorm g phase progress rb tumor proport cone precursor cell g phase increas signific meanwhil result differenti analysi microgli popul rb progress show key gene main involv immun respons includ rpl bm hla superfamili gene studi provid new perspect data resourc research rb pathogenesi progress
|
D012175;D019572
|
T191
|
36,305,410
|
singl cell transcriptom analysi multigrad glioma heterogen immun microenviron reveal potenti prognost biomark glioma common intrins tumor central nervous system character high incid poor prognosi aim studi identifi differenti express gene deg glioblastoma multiform gbm low grade glioma lgg explor prognost factor differ grade glioma singl cell transcriptom sequenc data glioma collect ncbi gene express omnibus geo includ total cell sampl three dataset analysi human glioma differ grade cell obtain filter gene screen differenti express gene gene ontolog go analysi kyoto encyclopedia gene genom kegg pathway analysi gene dll focus review literatur tcga base gene express profil interact analysi gepia databas use explor surviv curv gene lgg gbm gene express profil interact analysi tumor immun estim resourc timer databas use studi express key gene glioma differ grade predict biomark close relat immunotherapi cbioport databas use explor relationship dll express immun checkpoint gene set enrich analysi gsea identifi pathway associ central gene final efficaci biomark prognosi predict valid chines glioma genom atlas cgga result demonstr prognost gene associ tumor prolifer progress analysi biolog inform surviv suggest gene might serv promis prognost biomark new target select therapeut strategi
|
D001932;D005909;D005910
|
T191
|
36,305,409
|
genom wide identif bvhak gene famili sugar beet beta vulgari express analysi salt treatment high affin k transport hak one import k transport famili plant play import role plant k uptak transport explor biolog function gene express pattern hak gene famili member sugar beet beta vulgari physicochem properti gene structur chromosom locat phylogenet evolut conserv motif three dimension structur interact network cis act element promot bvhak predict bioinformat analysi express level differ tissu sugar beet salt stress analyz qrt pcr total bvhak gene identifi sugar beet genom contain exon intron averag number amino acid averag molecular weight kda isoelectr point bvhak protein contain transmembran region bvhak local plasma membran other local tonoplast phylogenet analysi show hak higher plant divid five cluster name cluster among member cluster divid three subclust includ b c bvhak gene famili member distribut cluster member respect promot bvhak gene famili main contain stress respons element hormon respons element growth develop respons element express pattern bvhak gene analyz differ tissu sugar beet upon salt treatment found mmoll nacl signific induc express bvhak gene shoot root high salt mmoll treatment clear regul express level shoot root result suggest bvhak gene famili play import role respons sugar beet salt stress
|
D027461
|
T168;T002
|
36,305,408
|
identif soybean gol gene famili analysi express pattern salt drought stress galactinol synthas gol key enzym biosynthet pathway raffinos famili oligosaccharid rfos play import role plant respons abiot stress howev molecular characterist gol famili member soybean well known studi six member gmgol gene famili genom wide identifi physicochem properti chromosom local evolutionari relationship gene structur conserv motif secondari structur tertiari structur tissu specif express pattern express level salt drought stress analyz result show six soybean gol gene uneven distribut four chromosom rang isoelectr point six gmgol protein molecular weight rang da number amino acid aa result subcellular local show protein locat chloroplast protein cytoplasm phylogenet tree analysi show member soybean gol gene famili close adjac evolutionarili conserv six gene member contain exon predict secondari tertiari structur show spatial structur protein famili member main compos helix random coil structur less turn extend chain structur tissu specif express analysi show six gmgol member express variabl degre seed root root hair flower stem pod nodul leav express analysi base qrt pcr show gmgol gene show differ degre regul express salt drought treatment indic gene may relat respons plant salt toler drought resist result may facilit subsequ function analysi soybean gol gene
|
D055864;D013025
|
T168;T070
|
36,305,407
|
identif terpen synthas gene famili member rhododendron relationship terpenoid metabol terpen synthas tps play import role synthesi terpenoid main fragranc rhododendron flower understand function tps gene terpenoid metabol relat flower aroma format identifi tps gene famili member rhododendron analyz genom databas use transcriptom approach analyz differenti gene express pattern tps gene famili member scent flower rhododendron fortunei compar non scent flower rhododendron nova zembla content terpenoid compound petal two rhododendron speci differ development stage also measur use qrt pcr head space solid phase micro extract combin gas chromatographi mass spectrometri result show total rstps member individu length rang bp identifi rhododendron genom number exon rstps gene rang length protein encod rang amino acid member rstps famili main distribut chloroplast cytoplasm phylogenet analysi show rstps gene cluster subgroup seven gene famili member function annot tps gene famili sinc tempor spatial express shown transcriptom data notabl tps tps tps tps rhododendron fortunei express high flower bud reach peak full blossom correl analysi gene express level terpenoid content indic express level tps tps tps tps tps tps posit correl content terpenoid petal r fortunei flower development stage suggest six gene might involv aroma format r fortunei
|
D029793
|
T002
|
36,305,406
|
genom wide identif effect mdpepc famili gene axillari bud outgrowth appl malus domestica borkh pepc famili protein ubiquit various plant play import role process photosynthet carbon assimil mani non photosynthet biolog function howev pepc gene report appl studi member appl mdpepc famili identifi base new appl genom data bioinformat analysi express pattern differ tissu appl axillari bud transcriptom treat decapit tdz cytokinin analyz order explor role mdpepc gene appl axillari bud outgrowth result show mdpepc famili member identifi appl distribut differ chromosom similar physicochem characterist phylogenet tree sequenc align analysi show mdpepc could divid two subgroup group group four member mdpepc famili cluster group belong plant type pepc howev mdpepc mdpepc cluster group atppc belong bacteri type pepc pair fragment repeat among mdpepc member tandem repeat exist promot cis act element analysi show mdpepc gene affect light stress also regul multipl hormon express profil show mdpepc except mdpepc mdpepc express differ appl tissu transcriptom data analysi show express level mdpepc mdpepc regul decapit tdz treatment wherea mdpepc signific regul h treatment conclus mdpepc mdpepc mdpepc select candid gene involv axillari bud outgrowth regul studi
|
D027845;D049248
|
T168;T037;T002
|
36,305,405
|
chloroplast genom malus floribunda siebold malus floribunda siebold malus wide cultiv world high ornament valu breed signific compar analysi chloroplast genom help enrich phylogenet relationship facilit germplasm util malus base whole genom sequenc data complet chloroplast genom floribunda tetrad structur assembl chloroplast genom bp compos larg singl copi lsc region bp invert repeat ir b bp small singl copi ssc region bp ira bp total gene annot protein code gene trna gene rrna gene addit larg number repeat sequenc identifi genom slight differ sieboldii toringoid relat synonym codon usag high frequenc codon found codon tend end result interspecif sequenc align boundari analysi suggest sequenc variat lsc region larg expans contract sc region ir region eight malus speci general similar accord phylogenet analysi chloroplast genom sequenc floribunda hupehensi toringoid group one clade find studi provid data support develop genet marker util germplasm resourc futur
|
D054628;D027845
|
T168;T002;T028
|
36,305,404
|
compar genom chloroplast sinopodophyllum hexandrum explor differ chloroplast genom characterist sinopodophyllum hexandrum five chloroplast genom sequenc hexandrum compar genom map repeat sequenc codon prefer invert repeat ir singl copi sc boundari align chloroplast genom sequenc phylogenet analyz use bioinformat tool result show total length five chloroplast genom hexandrum typic tetrad structur bp total gene annot reflect divers chloroplast genom hexandrum differ chloroplast genom hexandrum differ simpl sequenc repeat ssr simpl repeat singl nucleotid major among ssr detect interspers repetit sequenc includ direct palindrom invert repeat valu effect number codon enc analyz use codon bias proport gc gcs less codon usag pattern tend toward frequent use au end base genom sequenc irsc boundari five chloroplast genom hexandrum relat conserv phylogenet analysi show hexandrum podophyllum pettatum closest genet relationship summari chloroplast genom characterist evolutionari relationship differ chloroplast genom hexandrum obtain may facilit util protect varieti identif genet evolut hexandrum resourc
|
D054628
|
T028
|
36,305,403
|
mine gene cluster biosynthesi secondari metabolit analysi gene encod antibiot resist virul repres human gut strain genom sequenc repres strain human gut microbiota analyz mine gene cluster biosynthesi novel secondari metabolit well gene encod antibiot resist virul factor antismash analysi show repres strain encod least one secondari metabolit gene cluster potenti novel secondari metabolit gene cluster identifi uncultur bacteria secondari metabolit gene cluster human intestin main compos nonribosom peptid synthetas nrps bacteriocin arylpolyen terpen betalacton nrps like gene cluster distribut clostridia bacilli gammaproteobacteria bacteroidia actinobacteria negativicut pathofact analysi show gene encod antibiot resist virul factor wide distribut repres strain frequenc encod potenti pathogen signific higher non potenti pathogen frequenc gene encod secretori toxin outer membran protein papc n termin domain papc c termin domain peptidas inact domain non secretori toxin nitroreductas famili acrbacrdacrf famili pld like domain cupin domain putat hemolysin like peptidas phosphotransferas enzym famili endonucleas exonucleas phosphatas famili glyoxalas bleomycin resist high potenti pathogen studi may facilit mine new microbi natur product intestin microbiom understand colon infect mechan intestin microorgan provid target prevent treatment intestin microbi relat diseas
|
D005810;D001419
|
T007;T028
|
36,305,402
|
advanc liquid chromatographi mass spectrometri analysi sever import secondari metabolit plant metabolom metabolom main studi metabolit compon organ tissu cell dynam chang emerg omic technolog follow genom proteom metabolit final product cellular regul concentr metabolit consid ultim respons biolog system genet environment chang secondari metabolit chemic divers wide present live organ thus accur quantif secondari metabolit appropri analyt platform import task metabolom liquid chromatographi tandem mass spectrometri lc msms common use method detect metabolit provid basi wide applic plant secondari metabolit review summar advanc use lc msms techniqu detect phytohormon folic acid flavonoid secondari metabolit
|
D053719;D055432
|
T063;T091
|
36,305,401
|
glycosphingolipid mediat apoptosi tumor therapi review glycosphingolipid gsls wide distribut phospholipid bilay various cell membran play import role maintain cell membran stabil regul various cellular process includ adhes prolifer apoptosi recognit well particip various cellular activ addit gsls involv process apoptosi also regul multipl signal tumorigenesi tumor develop tumor associ gsls expect use diagnost marker immunotherapeut target malign tumor find import implic studi apoptosi provid new direct tumor therapi review summar latest research progress gsls mediat apoptosi effect genesi develop metastasi tumor cell moreov discuss metabol pathway gsls mediat apoptosi applic tumor therapi well develop prospect target therapi strategi base gsls
|
D006028;D009369
|
T121;T191;T109
|
36,305,400
|
advanc method phosphopeptid enrich separ phosphoproteom research systemat depth studi phosphoproteom reli high reproduc specif phosphopeptid enrich method present varieti enrich method develop base differ principl method often display differ select specif therefor import select suitabl enrich method accord differ research purpos review summar phosphopeptid enrich base affin chromatographi immunoprecipit chemic derivat chromatographi newli develop method advantag disadvantag method well relat optim improv strategi discuss detail addit also briefli summar progress combin phosphopeptid enrich fraction method develop recent year
|
D010748;D040901
|
T091;T116
|
36,305,399
|
distinguish human characterist base hair metabolom proteom review human hair kind natur fiber main compos keratin keratin associ protein good biolog sampl use character status bodi certain period time high import detect drug alcohol stimul advantag low cost easi collect easi transport storag proteom emerg technolog wide use field life scienc studi protein express regul holist level investig composit dynam chang hair protein differ popul would great potenti find diseas marker distinguish person trait paper structur composit hair chang hair composit psycholog stress research progress hair proteom comprehens review help use hair proteom identifi bodi characterist
|
D040821;D040901
|
T091;T102
|
36,305,398
|
thermal proteom profil techniqu comprehens assess protein status thermal proteom profil tpp combin cellular thermal shift assay cetsa quantit mass spectrometri ms also term ms cetsa tpp determin stabil entir proteom measur content solubl protein cell cell lysat differ heat temperatur protein chang thermost interact small molecul eg drug metabolit nucleic acid protein posttransl modif tpp identifi target protein base differ thermost without ligand bind present tpp appli identifi target target drug interrog protein metabolit protein protein interact due limit understand technolog review introduc principl method applic advantag limit tpp
|
D020543
|
T123;T116
|
36,305,397
|
precis oncolog proteogenom perspect cancer heterogen diseas complex mechan requir target precis medicin strategi growth precis medicin indispens rapid develop genom howev genom certain limit molecular phenotyp analysi proteogenom thus aros right time proteogenom merg proteom genom review describ limit genom analysi highlight import proteogenom understand precis oncolog proteogenom perspect addit applic proteogenom precis oncolog briefli introduc relat public data project describ final challeng need address stage propos
|
D000071696;D009369
|
T191;T091
|
36,305,396
|
advanc microbi transcriptom techniqu rapid develop molecular biotechnolog transcriptom wide use studi gene express recent year techniqu microbi transcriptom research also rapid develop gene level way obtain sequenc inform develop complementari valid rna fragment dna microarray direct sequenc full length rna spatial tradit popul transcriptom techniqu develop spatial singl cell epigenet transcriptom studi applic transcriptom techniqu field microbi research correspond defect gradual reveal constant improv paper tradit new transcriptom techniqu field microbi research summar provid refer microbi transcriptom research
|
D059467;D012313
|
T081;T114;T086
|
36,305,395
|
applic metagenom culturom technolog fecal microbiota transplant review fecal microbiota transplant fmt refer use intestin microorgan present fece process fece healthi peopl treat various type diseas digest metabol diseas rapid develop metagenom culturom technolog gut microbiom analysi provid power tool fmt research clinic applic metagenom technolog comprehens reveal divers function gut microbiota health diseas condit culturom technolog help isol identif uncultur bacteria human gut convent cultur condit combin two technolog enabl us better understand fmt regular caus effect clinic practic also effect promot applic consid advantag articl summar applic metagenom culturom technolog fmt prospect futur develop trend
|
D000069467;D000069196
|
T061;T007;T001
|
36,305,394
|
multi omic technolog applic life scienc review technolog advanc high throughput sequenc high resolut mass spectrometri multi omic data integr tool data repositori omic research life scienc evolv singl omic strategi multi omic strategi research system biolog driven multi omic bring new paradigm life scienc paper briefli summar develop genom epigenom transcriptom proteom metabolom highlight composit function multi omic platform well applic multi omic technolog prospect futur applic multi omic synthet biolog biomedicin
|
D023281;D040901
|
T091
|
36,305,393
|
prefac special issu multi omic frontier technolog wide applic genom transcriptom proteom metabolom post genom era function explan becom central task life scienc research multi omic data integr analysi becom indispens strategi uncov under biolog mechan special issu aim introduc relat research advanc applic multi omic invit domest expert total paper collect issu research refer multi omic
|
D023281;D040901
|
T091
|
36,305,391
|
bodi weight chang bipolar disord molecular pathway analysi evid suggest link weight relat disord bipolar disord bd pathophysiolog associ includ psycholog social psychotrop treatment relat variabl togeth psychiatr comorbid weight chang bd may influenc complianc treatment qualiti life prognosi modul risk death associ exampl diabet cardiovascular disord
|
D001714
|
T048
|
36,305,390
|
patient prefer current practic adult steroid resist ulcer coliti popster mix method studi corticosteroid mainstay treatment moder sever relaps ulcer coliti yet almost patient respond fulli risk prolong steroid use side effect lack clariti definit steroid resist optimum choic treatment patient health care profession treatment prefer
|
D003093;D000086382
|
T047;T067
|
36,305,379
|
gene base burden analysi damag privat variant prkn park pink parkinson diseas cohort european descent recess mutat prkn park pink establish caus earli onset parkinson diseas eopd previous studi interrog role heterozyg variant gene main focus rare minor allel frequenc maf lt damag variant establish mutat assess heterozyg privat prkn park pink variant pd risk four larg scale pd case control dataset perform gene wise burden analys use sequenc data total pd case control summari allel count pd case control result show signific burden three gene meta analys burden eopd age onset lt year late onset pd year remain nonsignific summari found evid support associ excess burden heterozyg privat variant prkn park pink pd risk european popul larger divers cohort need accur determin role pd
|
D010300;D000071617;D011494;D044767
|
T047;T126;T116
|
36,305,373
|
clinic microbiolog characterist staphylococcus lugdunensi review provid updat recent find clinic microbiolog characterist staphylococcus lugdunensi
|
D057787;D013203
|
T047;T007
|
36,305,362
|
eros arthriti system lupus erythematosus applic cluster analysi present studi appli cluster analysi ca sle patient joint involv identifi diseas subset common develop eros damag
|
D008180;D001168
|
T047
|
36,305,337
|
listeriosi outbreak caus contamin stuf pork andalusia spain juli octob juli octob andalusia spain larg outbreak confirm case listeriosi identifi confirm case median age year rang women case n mild gastroenter requir hospitalis three die five pregnant women miscarriag median incub period day rang signific shorter case present gastroenter compar present without gastroenter day vs day respect p valu stuf pork readi eat product consum unheat singl produc contamin listeria monocytogen st identifi sourc infect outbreak strain identifi human sampl non human food environment sampl notif new case declin abrupt control measur implement includ contamin food recal protocol clinic manag suspect case post exposur prophylaxi pregnant women communic campaign concis messag popul social media given probabl case largest l monocytogen outbreak ever report europ
|
D000080305;D000069466;D008088;D008089;D005759;D005517
|
T168;T047;T007;T037
|
36,305,336
|
integr genom surveil enabl trace person person sar cov transmiss chain communiti transmiss reveal extens onward transmiss travel import infect germani june juli backgroundtrack person person sar cov transmiss popul import understand epidemiolog communiti transmiss may contribut contain sar cov neither contact trace genom surveil alon howev typic suffici achiev objectiveaimw demonstr success applic integr genom surveil ig system german citi dsseldorf trace sar cov transmiss chain popul well detect investig travel associ sar cov infect clustersmethodsgenom surveil phylogenet analysi structur case interview integr elucid two genet defin cluster sar cov isol detect ig dsseldorf juli resultsclust n dsseldorf case cluster n detect surveil dataset high qualiti sar cov genom dsseldorf total case sampl mid june juli cluster could trace back complex pattern transmiss nightlif venu follow putat import sar cov infect return travel ip late june sar cov case could epidemiolog direct link ip support viral genom data spain cluster shown repres multipl independ introduct event viral strain circul catalonia european countri follow diffus communiti transmiss dsseldorfconclusionig enabl high resolut trace sar cov transmiss intern connect citi communiti transmiss provid infect chain level evid downstream propag travel import sar cov case
|
D000076263;D000086382
|
T047;T067
|
36,305,334
|
nosocomi outbreak ndm produc klebsiella pneumonia high resist cefiderocol florenc itali august june nosocomi outbreak cefiderocol fdc resist ndm produc klebsiella pneumonia ndm kp occur larg tertiari care hospit august june florenc itali area ndm kp strain becom endem retrospect analysi ndm kp case observ januari june reveal fdc resist outbreak most sustain clonal expans mutant inactiv cira siderophor receptor gene exhibit high level resist fdc mic mgl spread independ fdc exposur
|
D007710;D003428
|
T047
|
36,305,333
|
one health real time surveil system nowcast campylobact gastrointestin ill outbreak norway week week background campylobact lead caus food waterborn ill monitor model campylobact chicken broiler farm combin weather pattern surveil aid nowcast human gastrointestin gi ill outbreak near real time share data model result health author help increas potenti outbreak responsivenessaimsto leverag data weather campylobact broiler farm build risk model possibl human campylobact outbreak communic risk assess health authoritiesmethodsw develop spatio tempor random effect model week gi ill consult norwegian municip campylobact monitor weather data week give week nowcast gi ill outbreak approach combin municip random effect baselin model season adjust gi ill second model peak deviat baselin model result communic nation local stakehold interact websit sykdomspulsen one healthresultslag temperatur precipit covari well week lag posit campylobact sampl broiler associ higher level gi consult signific inter municip variabl outbreak nowcast observedconclus campylobact surveil broiler use gi ill outbreak nowcast surveil campylobact along potenti pathway environ ill via water system monitor may improv nowcast one health system communic near real time surveil data nowcast chang risk health profession facilit prevent campylobact outbreak reduc impact human health
|
D002167;D000074823;D002169
|
T078;T047;T007
|
36,305,327
|
bone miner densiti refer valu year old popul lombardi region itali aim studi assess bone miner densiti bmd score refer valu popul year old lombardi region itali studi also investig associ bmd valu bodi mass index bmi divid gender age evalu bmd analyz score bmd site femur column total patient femal male year enrol studi women hip femur refer valu associ situat osteopenia highlight line class age year mean valu score confid interv ci osteoporosi class age year mean valu score ci men hip femur refer valu associ situat osteopenia highlight line class age year mean valu score ci posit associ bmi two site bmd record p studi provid italian overview nation region refer valu bmd score valu divid age gender refer valu clinician correct assess monitor
|
D010024;D001851
|
T047
|
36,305,270
|
serpinb administr protect liver ischemia reperfus injuri investig chang serpinb hepat ischemia potenti role antiproteas activ cell protect administr wild type serpinb serpinb wt activ loop delet recombin serpinb protein serpinb rat model ischemia min reperfus min ir time depend increas serpinb transcript protein level found ischem liver min serpinb wt decreas polymorphonuclear cell infiltr serum enzym increas atp compar ir group event obtain use serpinb signific chang liver serpinb mrna protein found ir group consid present data show administr serpinb wt reduc ir injuri effect appear depend anti proteas activ
|
D008099;D015427
|
T023;T037
|
36,305,269
|
vegf promot diabet retinopathi upregul pkcetnf bicam signal pathway diabet retinopathi dr common microvascular complic patient diabet mellitus dr caus chronic hyperglycemia character progress loss vision damag retin microvasculatur studi investig regulatori role clinic signific vascular endotheli growth factor vegf protein kinas c pkc endothelin et nuclear factor b nf b intercellular adhes molecul icam signal pathway dr use rat model intraperiton inject vegf agonist streptozotocin stz use generat dr model rat dr rat treat vegf inhibitor drvegf inhibitor use studi specif effect vegf dr patholog under mechan dr drvegf agonist rat inject pkc inhibitor gfx determin therapeut potenti block vegfpkcetnf bicam signal pathway bodi weight blood glucos level rat group evalu week dr relat retin histopatholog analyz hematoxylin eosin stain elisa assay use estim pkc activ retin tissu western blot rt qpcr assay use analyz express level pkc vegf et nf b icam retin tissu immunohistochemistri use analyz vegf icam express rat retin tissu result show vegf icam pkc et nf b express level well pkc activ signific increas retin tissu dr drvegf agonist rat group compar control drvegf inhibitor rat group dr drvegf agonist rat show signific lower bodi weight signific higher retin histopatholog score blood glucos level compar control drvegf inhibitor group rat howev treatment dr drvegf agonist rat gfx partial allevi dr patholog inhibit vegf pkcetnf bicam signal pathway summari data demonstr inhibit vegf pkcetnf bicam signal pathway signific allevi dr relat patholog rat model therefor vegfpkcetnf bicam signal axi promis therapeut target dr
|
D003930;D003921
|
T047;T050
|
36,305,222
|
hybrid doubl spiral microfluid chip rbc lysi free enrich rare cell whole blood drug select treatment monitor via minim invas liquid biopsi use circul tumor cell ctcs expect realiz near futur clinic applic ctcs simpl high throughput singl step ctc isol whole blood without red blood cell rbc lysi centrifug remain crucial challeng studi develop novel cancer cell separ chip hybrid doubl spiral chip involv serial combin two differ dean flow fraction dff separ mode half full dean cycl hybrid dff separ mode ultra high throughput blood process high precis size resolut separ chip allow fast process ml whole blood within min without rbc lysi centrifug rbc white blood cell wbc deplet rate respect achiev averag recoveri rate spike cancer cell low cell ml blood devic achiev serial reduct number cell approxim cell whole blood cell subsequ order cell develop method combin measur recov cell use imag flow cytometri proof concept ctcs success enrich enumer blood metastat breast cancer patient n ctcs per ml metastat prostat cancer patient n ctcs per ml believ develop method benefici autom clinic analysi rare ctcs whole blood
|
D046210;D009360
|
T191;T059;T025
|
36,305,212
|
recurr rash year old boy pericardi pleural effus year old previous healthi boy present emerg center ec acut respiratori distress set month recurr worsen rash progress fatigu short breath chest pain cough onset rash younger brother diagnos roseola although brother symptom resolv patient rash recur prompt primari care provid prescrib amoxicillin rash subsequ worsen amoxicillin stop prednison cours prescrib allevi rash upon complet prednison cours rash return diffus associ symptom short breath chest pain cough symptom mother brought ec vital notabl tachypnea tachycardia initi ec imag workup remark echocardiogram mild moder circumferenti pericardi effus chest x ray cxr larg right pleural effus chest computer tomographi signific promin diffus mediastin hilar lymphadenopathi numer enlarg axillari lymph node laboratori result notabl elev liver enzym inflammatori marker dimer brain natriuret peptid differenti diagnosi remain broad includ infecti oncolog rheumatolog etiolog panel expert review evalu hospit cours treatment patient present unusu rash seros
|
D010996;D005076
|
T184;T047
|
36,305,188
|
effect week hydroxyprogesteron caproat small gestat age among pregnant women hiv zambia ipop trial demonstr reduc risk sever small gestat age among infant born women hiv receiv week intramuscular alpha hydroxyprogesteron caproat secondari analysi examin p treatment effect subgroup matern bmi pariti time antiretrovir therapi art initi art regimen found p effect among nullipar women women start art pregnanc take proteas inhibitor
|
D000077713;D015658;D047928
|
T121;T109;T125;T047;T046
|
36,305,182
|
urin tenofovir monitor predict hiv viremia patient treat high genet barrier regimen access viral load measur constrain resourc limit set later flow urin tenofovir tfv rapid assay utra patient whose regimen includ tfv offer afford approach frequent adher monitor
|
D019380;D015658
|
T121;T047
|
36,305,181
|
impact cost effect non government organ hiv epidem ukrain among msm non government organ ngos ukrain provid hiv test treatment condom distribut msm hiv preval among msm ukrain estim impact cost effect msm target ngo activ ukrain
|
D015658;D000072339
|
T047;T098
|
36,305,180
|
low frequenc pre treatment hiv drug resist effect year outcom first line efavirenz base antiretrovir therapi assess impact pre treatment high frequenc low frequenc drug resist hiv variant long term outcom first line efavirenz base antiretrovir therapi art
|
D019380;D024882;D015658
|
T121;T047;T032
|
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